CA2067178A1 - Solid tumor treatment method and composition - Google Patents

Solid tumor treatment method and composition

Info

Publication number
CA2067178A1
CA2067178A1 CA2067178A CA2067178A CA2067178A1 CA 2067178 A1 CA2067178 A1 CA 2067178A1 CA 2067178 A CA2067178 A CA 2067178A CA 2067178 A CA2067178 A CA 2067178A CA 2067178 A1 CA2067178 A1 CA 2067178A1
Authority
CA
Canada
Prior art keywords
composition
solid tumor
liposomes
compound
entrapped
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA2067178A
Other languages
French (fr)
Other versions
CA2067178C (en
Inventor
Francis J. Martin
Martin C. Woodle
Carl Redemann
Annie Yau-Young
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alza Corp
Original Assignee
Francis J. Martin
Martin C. Woodle
Carl Redemann
Annie Yau-Young
Liposome Technology, Inc.
Sequus Pharmaceuticals, Inc.
Alza Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23685679&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2067178(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Francis J. Martin, Martin C. Woodle, Carl Redemann, Annie Yau-Young, Liposome Technology, Inc., Sequus Pharmaceuticals, Inc., Alza Corporation filed Critical Francis J. Martin
Publication of CA2067178A1 publication Critical patent/CA2067178A1/en
Application granted granted Critical
Publication of CA2067178C publication Critical patent/CA2067178C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/5537—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom the heteroring containing the structure -C(=O)-N-C(=O)- (both carbon atoms belong to the heteroring)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6905—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion
    • A61K47/6911—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion the form being a liposome
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Abstract

A liposome composition for delivering a compound to a solid tumor via the bloodstream. The liposomes, which contain the agent in entrapped form, are composed of vesicle-forming lipids and between 1-20 mole percent of a vesicle-forming lipid deriva-tized with hydrophilic polymer, and have sizes in a selected size range between 0.07 and 0.12 microns. After intravenous adminis-tration, the liposomes are taken up by the tumor within 24-48 hours, for site-specific release of entrapped compound into the tu-mor. In one composition for use in treating a solid tumor, the compound is an anthracycline antibiotic drug which is entrapped in the liposomes at a concentration of greater than about 50 µg agent/µMole liposome lipid.
CA002067178A 1989-10-20 1990-10-19 Solid tumor treatment method and composition Expired - Lifetime CA2067178C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US425,224 1989-10-20
US07/425,224 US5013556A (en) 1989-10-20 1989-10-20 Liposomes with enhanced circulation time

Publications (2)

Publication Number Publication Date
CA2067178A1 true CA2067178A1 (en) 1991-04-21
CA2067178C CA2067178C (en) 1997-03-25

Family

ID=23685679

Family Applications (2)

Application Number Title Priority Date Filing Date
CA002067178A Expired - Lifetime CA2067178C (en) 1989-10-20 1990-10-19 Solid tumor treatment method and composition
CA002067133A Expired - Lifetime CA2067133C (en) 1989-10-20 1990-10-19 Liposome microreservoir composition and method

Family Applications After (1)

Application Number Title Priority Date Filing Date
CA002067133A Expired - Lifetime CA2067133C (en) 1989-10-20 1990-10-19 Liposome microreservoir composition and method

Country Status (18)

Country Link
US (2) US5013556A (en)
EP (2) EP0496813B1 (en)
JP (4) JP3571335B2 (en)
KR (2) KR920703013A (en)
AT (2) ATE115401T1 (en)
AU (2) AU642679B2 (en)
CA (2) CA2067178C (en)
DE (3) DE19675048I2 (en)
DK (1) DK0496835T3 (en)
ES (1) ES2071976T3 (en)
FI (2) FI105151B (en)
GR (1) GR3017060T3 (en)
HK (1) HK14097A (en)
IL (2) IL96069A (en)
LU (1) LU88854I2 (en)
NL (1) NL960031I2 (en)
NO (3) NO304637B1 (en)
WO (2) WO1991005545A1 (en)

Cited By (4)

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US5820873A (en) * 1994-09-30 1998-10-13 The University Of British Columbia Polyethylene glycol modified ceramide lipids and liposome uses thereof
US5885613A (en) * 1994-09-30 1999-03-23 The University Of British Columbia Bilayer stabilizing components and their use in forming programmable fusogenic liposomes
US6673364B1 (en) 1995-06-07 2004-01-06 The University Of British Columbia Liposome having an exchangeable component
US6734171B1 (en) 1997-10-10 2004-05-11 Inex Pharmaceuticals Corp. Methods for encapsulating nucleic acids in lipid bilayers

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