CA2093770A1 - Aspartic acid derivatives, their preparation and use - Google Patents
Aspartic acid derivatives, their preparation and useInfo
- Publication number
- CA2093770A1 CA2093770A1 CA002093770A CA2093770A CA2093770A1 CA 2093770 A1 CA2093770 A1 CA 2093770A1 CA 002093770 A CA002093770 A CA 002093770A CA 2093770 A CA2093770 A CA 2093770A CA 2093770 A1 CA2093770 A1 CA 2093770A1
- Authority
- CA
- Canada
- Prior art keywords
- aspartic acid
- acid derivatives
- preparation
- denotes
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
- C07D295/215—Radicals derived from nitrogen analogues of carbonic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
- C07C279/08—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by singly-bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/34—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06104—Dipeptides with the first amino acid being acidic
- C07K5/06113—Asp- or Asn-amino acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
- C07K5/0806—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/582—Recycling of unreacted starting or intermediate materials
Abstract
Aspartic acid derivatives of the formula (see formula I) in which X denotes, for example, (see formula II) and R denotes, for example, cyclohexylamino, have useful pharmacological properties. In particular, they have the ability to inhibit the binding of fibrinogen, fibronectin and von Willebrand factor to integrin receptors. They also inhibit platelet aggregation, metastasis of carcinoma cells and osteoclast formation on bone surfaces and are useful in prophylaxis and therapy of, for example, arterial vascular diseases and in the treatment of tumors.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DEP4212304.6 | 1992-04-13 | ||
DE4212304A DE4212304A1 (en) | 1992-04-13 | 1992-04-13 | Aspartic acid derivatives, their preparation and use |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2093770A1 true CA2093770A1 (en) | 1993-10-14 |
CA2093770C CA2093770C (en) | 2004-09-07 |
Family
ID=6456690
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002093770A Expired - Lifetime CA2093770C (en) | 1992-04-13 | 1993-04-08 | Aspartic acid derivatives, their preparation and use |
Country Status (15)
Country | Link |
---|---|
US (1) | US5399570A (en) |
EP (2) | EP0565896A2 (en) |
JP (1) | JP3504287B2 (en) |
KR (1) | KR930021605A (en) |
AT (1) | ATE307825T1 (en) |
AU (1) | AU659299B2 (en) |
CA (1) | CA2093770C (en) |
CZ (1) | CZ290280B6 (en) |
DE (2) | DE4212304A1 (en) |
ES (1) | ES2250980T3 (en) |
HU (1) | HU218206B (en) |
IL (1) | IL105355A (en) |
SK (1) | SK282125B6 (en) |
TW (1) | TW267158B (en) |
ZA (1) | ZA932535B (en) |
Cited By (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5446056A (en) * | 1993-11-24 | 1995-08-29 | The Du Pont Merck Pharmaceutical Company | Isoxazoline compounds useful as fibrinogen receptor antagonists |
US5494922A (en) * | 1993-06-28 | 1996-02-27 | Zeneca Limited | Allophanic acid derivatives |
US5523302A (en) * | 1993-11-24 | 1996-06-04 | The Du Pont Merck Pharmaceutical Company | Aromatic compounds containing basic and acidic termini useful as fibrinogen receptor antagonists |
US5556977A (en) * | 1993-03-29 | 1996-09-17 | Zeneca Limited | Heterocyclic derivatives |
US5563141A (en) * | 1993-03-29 | 1996-10-08 | Zeneca Limited | Heterocyclic compounds |
US5563158A (en) * | 1993-12-28 | 1996-10-08 | The Dupont Merck Pharmaceutical Company | Aromatic compounds containing basic and acidic termini useful as fibrinogen receptor antagonists |
US5576334A (en) * | 1993-06-28 | 1996-11-19 | Zeneca Limited | Acylurea derivatives |
US5612373A (en) * | 1993-06-28 | 1997-03-18 | Zeneca Limited | Certain diacyl hydrazine derivatives |
US5652242A (en) * | 1993-03-29 | 1997-07-29 | Zeneca Limited | Heterocyclic derivatives |
US5750754A (en) * | 1993-03-29 | 1998-05-12 | Zeneca Limited | Heterocyclic compounds |
US5753659A (en) * | 1993-03-29 | 1998-05-19 | Zeneca Limited | Heterocyclic compouds |
US5811441A (en) * | 1995-05-24 | 1998-09-22 | The Dupont Merck Pharmaceutical Company | Isoxazoline fibrinogen receptor antagonists |
US5849736A (en) * | 1993-11-24 | 1998-12-15 | The Dupont Merck Pharmaceutical Company | Isoxazoline and isoxazole fibrinogen receptor antagonists |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5169930A (en) * | 1990-01-05 | 1992-12-08 | La Jolla Cancer Research Foundation | Fibronectin receptor |
DK0513675T3 (en) * | 1991-05-13 | 1996-09-30 | Fujisawa Pharmaceutical Co | New peptide compound and method of preparation thereof |
TW257757B (en) * | 1993-03-03 | 1995-09-21 | Boehringer Mannheim Gmbh | |
US6274705B1 (en) * | 1996-05-02 | 2001-08-14 | Aventis Pharmaceuticals Products Inc. | Antithrombotic azacycloalkylalkanoyl peptides and pseudopeptides |
US7001921B1 (en) | 1995-01-23 | 2006-02-21 | Biogen Idec Ma Inc. | Cell adhesion inhibitors |
US6306840B1 (en) | 1995-01-23 | 2001-10-23 | Biogen, Inc. | Cell adhesion inhibitors |
US6248713B1 (en) | 1995-07-11 | 2001-06-19 | Biogen, Inc. | Cell adhesion inhibitors |
AU713676B2 (en) * | 1996-01-16 | 1999-12-09 | Merck & Co., Inc. | Integrin receptor antagonists |
US6239108B1 (en) | 1996-07-11 | 2001-05-29 | Biogen, Inc. | Cell adhesion inhibitors |
DE69737769T2 (en) | 1996-07-25 | 2008-05-15 | Biogen Idec Ma Inc., Cambridge | MOLECULE MODEL FOR VLA-4 INHIBITORS |
US6686350B1 (en) | 1996-07-25 | 2004-02-03 | Biogen, Inc. | Cell adhesion inhibitors |
US5759152A (en) * | 1996-10-02 | 1998-06-02 | Mayo Foundation For Medical Education And Research | Phase-aligned NMR surface coil image reconstruction |
WO1999055688A1 (en) * | 1998-04-27 | 1999-11-04 | Warner-Lambert Company | Substituted diarylalkyl amides as calcium channel antagonists |
EA002988B1 (en) | 1998-05-28 | 2002-12-26 | Байоджен, Инк. | (R)-N-[[4-[[(2-METHYLPHENYLAMINO)CARBONYL]AMINO]PHENYL]ACETYL]-L-PROPYL-3-METHYL)-BETA-ALANINE AND ITS USE AS A CELL ADHESION INHIBITOR MEDIATED BY INTEGRIN alpha4beta1 INHIBITORS |
SK287075B6 (en) * | 1999-08-13 | 2009-11-05 | Biogen Idec Ma Inc. | Cell adhesion inhibitors and pharmaceutical compositions comprising them |
US6875743B1 (en) | 2000-11-28 | 2005-04-05 | Biogen, Inc. | Cell adhesion inhibitors |
DE10204789A1 (en) * | 2002-02-06 | 2003-08-14 | Merck Patent Gmbh | Inhibitors of the integrin alpha¶v¶beta6 |
US20050192348A1 (en) * | 2003-09-25 | 2005-09-01 | David Bar-Or | Methods and products which utilize N-acyl-L-aspartic acid |
BRPI0509150B8 (en) * | 2004-03-24 | 2021-05-25 | Jerini Ag | compounds for the inhibition of angiogenesis and the use of these |
US7196112B2 (en) | 2004-07-16 | 2007-03-27 | Biogen Idec Ma Inc. | Cell adhesion inhibitors |
EP1853246A1 (en) * | 2005-02-17 | 2007-11-14 | Instituto del Metabolismo Celular, S.L. | L-aspartic acid for the treatment of problems in connection with the fat or glucose metabolism |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4879313A (en) * | 1988-07-20 | 1989-11-07 | Mosanto Company | Novel platelet-aggregation inhibitors |
US5039805A (en) * | 1988-12-08 | 1991-08-13 | Hoffmann-La Roche Inc. | Novel benzoic and phenylacetic acid derivatives |
US5084466A (en) * | 1989-01-31 | 1992-01-28 | Hoffmann-La Roche Inc. | Novel carboxamide pyridine compounds which have useful pharmaceutical utility |
US5318899A (en) * | 1989-06-16 | 1994-06-07 | Cor Therapeutics, Inc. | Platelet aggregation inhibitors |
US4952562A (en) * | 1989-09-29 | 1990-08-28 | Rorer Pharmaceutical Corporation | Anti-thrombotic peptides and pseudopeptides |
JPH05500954A (en) * | 1989-09-29 | 1993-02-25 | ローヌ―プーラン ローラー インターナショナル(ホウルディングス) インコーポレイテッド | Antithrombotic peptides and pseudopeptides |
US5051405A (en) * | 1989-10-10 | 1991-09-24 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Anti-thrombotic peptides and pseudopeptides |
US5086069A (en) * | 1990-02-05 | 1992-02-04 | Rorer Pharmaceutical Corporation | Anti-thrombotic peptide and pseudopeptide derivatives |
US5264420A (en) * | 1990-09-27 | 1993-11-23 | Merck & Co., Inc. | Fibrinogen receptor antagonists |
US5481021A (en) * | 1991-03-06 | 1996-01-02 | G. D. Searle & Co. | Phenyl amidines derivatives useful as platelet aggregation inhibitors |
US5227490A (en) * | 1992-02-21 | 1993-07-13 | Merck & Co., Inc. | Fibrinogen receptor antagonists |
-
1992
- 1992-04-13 DE DE4212304A patent/DE4212304A1/en not_active Withdrawn
-
1993
- 1993-03-18 EP EP93104415A patent/EP0565896A2/en not_active Withdrawn
- 1993-03-18 ES ES96102404T patent/ES2250980T3/en not_active Expired - Lifetime
- 1993-03-18 EP EP96102404A patent/EP0784058B8/en not_active Expired - Lifetime
- 1993-03-18 AT AT96102404T patent/ATE307825T1/en not_active IP Right Cessation
- 1993-03-18 DE DE59310379T patent/DE59310379D1/en not_active Expired - Lifetime
- 1993-03-22 TW TW082102118A patent/TW267158B/zh active
- 1993-03-24 CZ CZ1993494A patent/CZ290280B6/en not_active IP Right Cessation
- 1993-03-25 US US08/036,923 patent/US5399570A/en not_active Expired - Lifetime
- 1993-04-08 AU AU36836/93A patent/AU659299B2/en not_active Ceased
- 1993-04-08 CA CA002093770A patent/CA2093770C/en not_active Expired - Lifetime
- 1993-04-08 ZA ZA932535A patent/ZA932535B/en unknown
- 1993-04-09 IL IL105355A patent/IL105355A/en not_active IP Right Cessation
- 1993-04-09 SK SK334-93A patent/SK282125B6/en unknown
- 1993-04-12 KR KR1019930006039A patent/KR930021605A/en not_active Application Discontinuation
- 1993-04-12 JP JP08494693A patent/JP3504287B2/en not_active Expired - Fee Related
- 1993-04-13 HU HU9301071A patent/HU218206B/en not_active IP Right Cessation
Cited By (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5652242A (en) * | 1993-03-29 | 1997-07-29 | Zeneca Limited | Heterocyclic derivatives |
US5728701A (en) * | 1993-03-29 | 1998-03-17 | Zeneca Limited | Heterocyclic derivatives |
US5556977A (en) * | 1993-03-29 | 1996-09-17 | Zeneca Limited | Heterocyclic derivatives |
US5563141A (en) * | 1993-03-29 | 1996-10-08 | Zeneca Limited | Heterocyclic compounds |
US5753659A (en) * | 1993-03-29 | 1998-05-19 | Zeneca Limited | Heterocyclic compouds |
US5750754A (en) * | 1993-03-29 | 1998-05-12 | Zeneca Limited | Heterocyclic compounds |
US5981531A (en) * | 1993-06-28 | 1999-11-09 | Zeneca Limited | Acid derivatives |
US5760057A (en) * | 1993-06-28 | 1998-06-02 | Zeneca Limited | Certain (piperidin-4-yl-alkanoyl)carbazoyl!-carboxy-phenoxy derivatives |
US5576334A (en) * | 1993-06-28 | 1996-11-19 | Zeneca Limited | Acylurea derivatives |
US5612373A (en) * | 1993-06-28 | 1997-03-18 | Zeneca Limited | Certain diacyl hydrazine derivatives |
US5494922A (en) * | 1993-06-28 | 1996-02-27 | Zeneca Limited | Allophanic acid derivatives |
US6114328A (en) * | 1993-11-24 | 2000-09-05 | Dupont Pharmaceuticals Company | Isoxazoline and isoxazole fibrogen receptor antagonists |
US5739163A (en) * | 1993-11-24 | 1998-04-14 | The Dupont Merck Pharmaceutical Company | Aromatic compounds containing basic and acidic termini useful as fibrinogen receptor antagonists |
US5523302A (en) * | 1993-11-24 | 1996-06-04 | The Du Pont Merck Pharmaceutical Company | Aromatic compounds containing basic and acidic termini useful as fibrinogen receptor antagonists |
US5849736A (en) * | 1993-11-24 | 1998-12-15 | The Dupont Merck Pharmaceutical Company | Isoxazoline and isoxazole fibrinogen receptor antagonists |
US5446056A (en) * | 1993-11-24 | 1995-08-29 | The Du Pont Merck Pharmaceutical Company | Isoxazoline compounds useful as fibrinogen receptor antagonists |
US5563158A (en) * | 1993-12-28 | 1996-10-08 | The Dupont Merck Pharmaceutical Company | Aromatic compounds containing basic and acidic termini useful as fibrinogen receptor antagonists |
US5691329A (en) * | 1993-12-28 | 1997-11-25 | The Dupont Merck Pharmaceutical Company | Compounds containing basic and acidic termini useful as fibrinogen receptor antagonists |
US5811441A (en) * | 1995-05-24 | 1998-09-22 | The Dupont Merck Pharmaceutical Company | Isoxazoline fibrinogen receptor antagonists |
Also Published As
Publication number | Publication date |
---|---|
IL105355A0 (en) | 1993-08-18 |
ZA932535B (en) | 1993-11-04 |
JP3504287B2 (en) | 2004-03-08 |
ES2250980T3 (en) | 2006-04-16 |
EP0565896A2 (en) | 1993-10-20 |
CA2093770C (en) | 2004-09-07 |
EP0784058A1 (en) | 1997-07-16 |
DE4212304A1 (en) | 1993-10-14 |
EP0565896A3 (en) | 1994-01-12 |
CZ49493A3 (en) | 1994-02-16 |
JPH07109256A (en) | 1995-04-25 |
SK33493A3 (en) | 1994-02-02 |
KR930021605A (en) | 1993-11-22 |
TW267158B (en) | 1996-01-01 |
AU3683693A (en) | 1993-10-14 |
HU9301071D0 (en) | 1993-06-28 |
AU659299B2 (en) | 1995-05-11 |
DE59310379D1 (en) | 2005-12-01 |
EP0784058B8 (en) | 2005-12-28 |
HUT64016A (en) | 1993-11-29 |
US5399570A (en) | 1995-03-21 |
SK282125B6 (en) | 2001-11-06 |
IL105355A (en) | 1998-03-10 |
ATE307825T1 (en) | 2005-11-15 |
EP0784058B1 (en) | 2005-10-26 |
CZ290280B6 (en) | 2002-07-17 |
HU218206B (en) | 2000-06-28 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CA2093770A1 (en) | Aspartic acid derivatives, their preparation and use | |
AU1611192A (en) | Fibrinogen receptor antagonists | |
NO913785D0 (en) | PROCEDURE FOR MANUFACTURING FIBRINOGENE RECEPTOR ANTAGONISTS. | |
CA2017025A1 (en) | Tumor necrosis factor binding protein ii, its purification and antibodies thereto | |
DK0512829T3 (en) | fibrinogen | |
ZA94615B (en) | Piperazine derivatives | |
CA2130174A1 (en) | 4-oxo-2 thioxoimidazolidine derivatives as inhibitors of blood platelet aggregation | |
IE882335L (en) | Pyridinium derivatives, their production and use | |
DE68906609D1 (en) | DOPAMIN PRECURRENT. | |
IL112020A0 (en) | Arylacetic acid derivatives, their preparation and their use as fungicides | |
MX9709910A (en) | Inhibitors of factor xa. | |
MY120550A (en) | Substituted 1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocin-10-ols, processes for preparing them and their use as pharmaceutical compositions. | |
CA2014062A1 (en) | Pyridine derivatives | |
TR199901416T2 (en) | Heterocyclic carbonicacyte térevleri. | |
RU94000064A (en) | New 2-cyano-3-hydroxypropeneamides, method of preparing thereof, and pharmaceutical compositions containing said compounds | |
EP0337334A3 (en) | Renin-inhibiting amino acid derivatives | |
DE59010865D1 (en) | N-SUBSTITUTED NAPHTHALIMIDES, THEIR PRODUCTION AND USE | |
MX9705737A (en) | Substituted indanylidineacetylguanidines, process for their preparation, their use as medicaments or diagnosis agents, and medicaments containing them. | |
ES8605518A1 (en) | 4-Oxo-pyrido-[2,3-d]pyrimidine derivatives, process for their preparation and medicaments containing them. | |
YU3701A (en) | Substituted phenylamidines with antithrombotic action | |
WO1990010006A3 (en) | NOVEL β-METHOXYACRYLATES, THEIR PRODUCTION AND USE | |
EP1806356A3 (en) | Substituted heterocyclic acyl-tripeptides useful as thrombin receptor modulators | |
CA2200846A1 (en) | Promoter for the receptor tyrosine kinase, tie | |
MX9709908A (en) | Ketoheterocyclic inhibitors of factor xa. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKLA | Lapsed |
Effective date: 20130408 |
|
MKEC | Expiry (correction) |
Effective date: 20131009 |