CA2093868C - Child resistant reminder closure - Google Patents

Child resistant reminder closure Download PDF

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Publication number
CA2093868C
CA2093868C CA002093868A CA2093868A CA2093868C CA 2093868 C CA2093868 C CA 2093868C CA 002093868 A CA002093868 A CA 002093868A CA 2093868 A CA2093868 A CA 2093868A CA 2093868 C CA2093868 C CA 2093868C
Authority
CA
Canada
Prior art keywords
closure member
disk
outer closure
lugs
day
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA002093868A
Other languages
French (fr)
Other versions
CA2093868A1 (en
Inventor
Maximillian Kusz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BPrex Healthcare Brookville Inc
Original Assignee
Owens Illinois Closure Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Owens Illinois Closure Inc filed Critical Owens Illinois Closure Inc
Publication of CA2093868A1 publication Critical patent/CA2093868A1/en
Application granted granted Critical
Publication of CA2093868C publication Critical patent/CA2093868C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • BPERFORMING OPERATIONS; TRANSPORTING
    • B65CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65DCONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D50/00Closures with means for discouraging unauthorised opening or removal thereof, with or without indicating means, e.g. child-proof closures
    • B65D50/02Closures with means for discouraging unauthorised opening or removal thereof, with or without indicating means, e.g. child-proof closures openable or removable by the combination of plural actions
    • B65D50/04Closures with means for discouraging unauthorised opening or removal thereof, with or without indicating means, e.g. child-proof closures openable or removable by the combination of plural actions requiring the combination of simultaneous actions, e.g. depressing and turning, lifting and turning, maintaining a part and turning another one
    • B65D50/041Closures with means for discouraging unauthorised opening or removal thereof, with or without indicating means, e.g. child-proof closures openable or removable by the combination of plural actions requiring the combination of simultaneous actions, e.g. depressing and turning, lifting and turning, maintaining a part and turning another one the closure comprising nested inner and outer caps or an inner cap and an outer coaxial annular member, which can be brought into engagement to enable removal by rotation
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J7/00Devices for administering medicines orally, e.g. spoons; Pill counting devices; Arrangements for time indication or reminder for taking medicine
    • A61J7/04Arrangements for time indication or reminder for taking medicine, e.g. programmed dispensers
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B65CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65DCONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D2583/00Containers or packages with special means for dispensing contents
    • B65D2583/04For dispensing annular, disc-shaped or spherical or like small articles or tablets
    • B65D2583/0404Indications, e.g. directions for use
    • B65D2583/0409Indications, e.g. directions for use of dates or follow-numbers
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B65CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65DCONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D2585/00Containers, packaging elements or packages specially adapted for particular articles or materials
    • B65D2585/56Containers, packaging elements or packages specially adapted for particular articles or materials for medicinal tablets or pills

Abstract

A child resistant reminder closure comprising an outer closure member having a base wall and a peripheral skirt, an inner closure member having a base wall and a peripheral skirt with a bead on the outer closure member retaining the inner closure member against limited axial outward movement relative to the outer closure member. An assembly of a day disk and an indexing disk is provided in the outer closure member and is rotatable relative thereto. A first set of flexible radial ratcheting fingers extend radially from the day disk and engage radial lugs on the undersurface of the base wall of the outer closure member. A second set of flexible radial ratcheting fingers extend radially from the day disk and engage circumferentially spaced lugs on the upper surface of the indexing disk. Axially interengageable lugs and recesses are provided an the outer closure member and the indexing disk and interengaging lugs and recesses are provided between the indexing disk and the inner closure member which are interengaged to remove the closure or to apply the closure to a container thereby providing a child resistant feature. A window is provided on the outer closure member and is associated with indicia on the day disk to indicate the circumferential position of the outer closure member relative to the day disk.

Description

This invention relates to child resistant reminder closures.
~ackqr~und andl Sugary of the 7Caxventioa~
Regular use or maintenance of prescription drugs has become important in ensuring the health of users thereof and is being stressed and advocated by health authorities and governmental agencies such as the United States Food and Drug Administration. To comply with a regimen, it is helpful to remember when the person taking the medication last took the medication. One way of helping in this regard is to have a closure with a visual indicator of when the closure package was last opened or when the package should be opened next.
Current compliance closures use expensive battery operated indicators. Others use mechanical constructions that are complex and costly.
Typical closures of the mechanical type are shown in U.S. Patents 3,151,599, 4,011,289, 4,365~722 arid 5,009,338.
Such closures have the disadvantage that they require axial movement between the reminder components. The axial movement between an outer closure member and an inner closure member of a child resistant closure would not permit such normal axial movement between the components of such reminder closures. In addition, relative axial movement and rotation between the reminder components can cause wear and obliteration of the indicia.

Among the objectives of the present invention are to provide a child resistant reminder closure of the mechanical type which is reliable; which functions to repeatedly provide the desired information; which do not incorporate axial forces between the reminder components; wherein the components are reversible so that the change in visible indicia can be made either on application or removal of the closure; which utilizes old and well known child resistant construction; ana which can be manufactured readily in high-production, In accordance with the inventions a child resistant reminder closure comprising an outer closure member having a base wall and a peripheral skirt, an inner closure member having a base wall and a peripheral skirt with a bead on the outer closure member retaining the inner closure member against limited axial outward movement relative to the outer closure member.
An assembly of a day disk and an indexing disk is provided on the outer closure member and is rotatable relative thereto.
~'he day disk is provided adjacent the inner surface of the base wall of the outer closure member and is mounted on the underlying 2~ indexing disk. A first set of flexible radial ratcheting fingers extend radially from the day disk and engage radial lugs on the undersurface of the base wall of the outer closure member. A
second set of flexible radial ratcheting fingers extend radially from the day disk and engage circumferentially spaced lugs on the upper surface of the indexing disk. Axially interengageable lugs and recesses are provided on the outer closure member and the indexing disk and interengaging lugs and recesses are _2_ provided between the underside of the indexing disk and the inner closure member cahich are adapted to be engaged to remove or apply the closure from a container thereby providing a child resistant feature. A window is provided on the outer closure member and is associated with indicia o.n the day disk to indicate the circumferential position of the outer closure member relative to the day disk.

~~~~~~s Description of tt~e Drawings FIG. 1 is a perspective view of a child resistant package with a reminder closure.
FIG. 2 is a part sectional view on a greatly enlarged scale showing the closure.
FIG. 3 is a part sectional exploded view of the clasure.
FIG. 4 is a bottom plan view taken along the line 4-4 in FIG. 3.
FIG. 5 is a top plan view taken along the line 5-5 in FIG. 3.
FIG. 6 is a fragmentary sectional view on an enlarged scale taken along the line 6-6 in FIG. 5.
FIG. ? is a fragmentary sectional view on an enlarged scale taken at line ? in FIG, 3.
FIG. 8 is a sectional view of the eater closure member shown in FIG. 3.
FIG. 9 is a bottom plan view of the outer closure member shown in FIG. 8.
FIG. 10 is a fragmentary sectional view taken along the line 10-10 in FIG. 8.
FIG. 11 is a fragmentary view on an enlarged scale taken alang the line 11--11 in FIG. 10.
FIG. 12 is a top plan view of the outer closure shown in FIG. 8.
FIG, 13 is a fragmentary sectional view on an enlarged scale taken along the line 13-13 in FIG. 12.
FIG. 14 is a plan view of an indexing ring.

FIG. 15 is a fragmentary view on an enlarged scale taken along the line 15-15 in FIG. 14.
FIG. 16 is a fragmentary view on an enlarger scale taken along the line 16-16 in FIG. 14.
FTG. 17 iC a top perspective exploded view of the closure embodying the invention.
FIG. 1~ is a bottom exploded perspective view of the closure.
FIG. 19 is a bottom perspective view of the outer closure member with the indexing disk therein.
FIG. 20 is a tap perspective view of the inner closure member with the indexing disk and locking disk thereon.

Descr '~.~t 'ion Referring to Figs. i and 2, in accordance with the invention, the child resistant reminder closure 30 comprises an outer closure member 31 and an inner closure member 32 retained against limited axially outer movement by an annular bead.33. The closure 30 is adapted to be used with a container 34 having threads adapted to be engaged with the threads of the closure 30 as presently described.
As shown in Figs. 2-3, and 15 the outer closure member -10 31 comprises a base wall 35 and a peripheral skirt 36. An assembly of a day disk 37 arid an indexing disk 38 is retained against axial movement but permissible rotatable movement with respect to the outer closure member 31 by an annular rib 39 which engages an inclined surface 40 on the periphery of the indexing disk 38. The inner closure member 32 is of conventional child resistant construction as presently described and includes a base wall 41 and a peripheral skirt 42 having internal threads 43 that are adapted to engage threads 44 on the neck of the container 34. tFIG. 2).
Upon clockwise rotation of the outer closure member 31 combined with axial movement of the outer closure member 31 toward the inner closure member 32, the closure 30 is threaded onto the container. During this rotation, the outer closure member 31 ratchets past the day disk 37 bringing the succeeding indicia 65 into view through the opening 66, as preferably described.
_6_ The day disk 37 is reversible and indicia 65 can be provided on the opposite side as in FIG. 14. In such an arrangement, the rotation o.f the outer closure member 31 with respect to the day disk 37 occurs on application of the closure 30 to the container 34.
As shown in Fig, 14, the day disk 37 has an opening 45.
A plurality of equally spaced flexible ratcheting fingers 46 are provided on the outer periphery thereof that radially extend clockwise as viewed in Fig. 14 and a plurality of equally spaced and ratcheting flexible fingers 47 on the inner periphery of the opening 45 therein which extend radially circumferentially in the same direction. Fingers 46 are adapted to move into recesses 48 on lugs 49 extending axially from the indexing disk 38 (FIG. 20>. The flexible fingers 47 are adapted to engage axially extending radial ribs 50 on an annular wall 51 that is integral with and extends from the underside of the base wall 35 of the outer closure member 31 fFIG. 19).
As shown in FIG. 9, there are axially extending lugs 55 on the underside of the outer closure member 31. The lugs 55 are adapted to engage the lugs 49 on the indexing disk 38 when the closure 30 is rotated in either direction after a predetermined angle. Interengaging means comprising lugs 60 on the underside of the indexing disk 38 extend into spaces 62 between lugs 61 on the inner closure member 32 (FIG. 17). Upon axial movement of the outer closure member 31 relative to the inner closure member 32 and counterclockwise rotation of the 2~~38~8 outer closure member 31, engagement is provided between the lugs 60, 61 for unthreading the closure 30 from the container.
The day disk 37 includes indicia 65 for time, such as the days of the week or as shown in Fig. 14, for two sets of days of the week. The outer closure member 31 is provided with an opening 66 through which each of the indicia 65 may be viewed.
The indicia 65 are either embossed, debossed or printed. Upon clockwise rotation of the outer closure member 30 in a direction to apply the inner closure member 32, the abutments 50 deflect on depending ring 51 and ratate past the flexible elements 47 on the inner surface of the day disk 37.
The closure components are preferably made of plastic such as polypropylene or polyethylene and the day disk 37 preferably has a different color from the outer closure member 31.
The closure 30 is applied to the container 34 by rotating the closure onto the threads of the container in a clockwise direction. Continued rotation, in a clockwise direction as viewed from above tightens the threads. Rotation of the outer closure member 31 in a counterclockwise direction will normally merely cause the outer closure member to rotate relative to the inner closure member 32. In order to remove the closure 30 from the container, it is necessary to move the outer closure member 31 axially toward the inner closure member 32 bringing the lugs 60 on the indexing disk 38 and into the spaces 62 between the lugs 61 on the inner closure member 32 recesses whereby upon continued downward force and counterclockwise rotation of the outer closure member 31 the _g_ ~~~~~~8 inner closure member 32 is unthreaded from the container. During this rotation, and before the lugs 55 engage the lugs 49, the fingers 47 engage the ribs ~0 to rotate the day disk 37 with the outer closure member.
Referring to FIG. 2 and 3, segmented bead 39 on skirt 36 of the outer closure member 31 is positioned a specific distance from the top panel 35 such that indexing disk 38 and day disk 37 are retained within the upper region of outer closure member 31. There is sufficient axial distance between the segmented bead 39 and the top panel 35 of the outer closure member 31 that little or no axial dimensional interference exists between the outer closure member 31, the indexing disk 38 or the day disk 37. The outer closure member 31, the indexing disk 38 or the day disk 37 are free to rotate relative to each other but there is very limited axial movement between these parts because of segmented retaining bead 39. The axial height or thickness of the day disk 37 is less than the axial height of lugs 49 on indexing disk 38 and the lugs 55 on the outer closure member. This arrangement allows the outer closure member 31 and indexing disk 38 to operate in unison with regard to any axial movement of the outer closure 31. As a result, the axial forces on the outer closure do not interfere with the rotation of the reminder components. Furthermore, the axial forces do not cause wear and obliteration of the indicia.
_g_ Closure Removal To remove closure 30 from container 34, the outer closure member 31 must be rotated counterclockwise which causes the lugs 55 on the top panel 35 o.f out.er closure member.- 3i. to contact the sides of projections 49 on indexing disk 38 causing it to rotate in a counterclockwise direction. The lugs 60 on indexing disk 38 now contact the lugs 61 on the base wall 41 of inner closure member 32 and will cam up the inclined surface 70 of the succeeding projection 61 unless sufficient axial force is applied to prevent the lugs 60 from camming up this inclined surface. When sufficient downward force is exerted the lugs 60 will inpart rotational torque onto the inner closure 32 and cause it to unscrew from the container 34. The construction of such a child resistant feature is like that of United States Patent No. 4,997,096. Other well known child resistant constructions may also be used such as shown in United States Patent Nos. 4,353,474, 4,371,088, 4,480,759, 4,609,114, 4,947,210, 5,020,681 and U.K. 1,529,999, each of which functions with relative axial movement and torque between an outer closure member and an inner closure member.
Closure A plication and Tightening When the closure 30 is applied to the container 34 the outer closure member 31 is rotated in a clockwise direction causing the lugs 55 on its top panel to contact projections 49 on the base wall of the indexing disk 38 causing the indexing disk 30 to rotate in a clockwise direction bringing lugs 60 on its bottom panel into contact with sides 71 of lugs 61 on the top panel 41 of inner closure 32 causing it to turn in a clockwise direction. Continued rotation of outer closure member 31 will cause the inner closure 32 to become tightened into cantainer 34.
During the removal of the closure 30 from the container 34 rotation of the outer closure 31 causes ribs 50 on the ring 51 depending from top panel 35 to contact flexible projections 47 on the day disk 37 causing the day disk to also rotate in the removal direction (counterclockwise). This rotation of the day disk 37 causes the flexible projections 46 to rotate out of indexing pockets 48 in projections 49 on the indexing disk 38. This rotation of the outer closure 31 and day disk 37 with respect to indexing disk 38 continues until lugs 55 on the base wall 35 of outer closure member 31 come into contact with projections 49 on the indexing disk 38. The total angular rotation of the outer closure Member 31 arid day disk 37 with respect to the indexing disk 38 will have advanced the day disk one indexing position with respect to the indexing disk 37 and the day disk 38 will have remained stationary with respect to the outer closure 31. Therefore, the indicia on the day disk 37 viewed through window 66 on the outer closure 31 did not change during this counterclockwise rotation of the outer closure member 31.
When the closure 30 is applied to the container and the outer closure 31 is rotated in the clockwise direction, the day disk 37 remains stationary with respect to the indexing disk 38 because the flexible projections 46 are locked into the pockets 48 on projections 49 on the indexing disk, while ribs 50 on ring 51 on the outer closure 32 rotate past flexible projections 47 on the interior of day disk 37. This rotation continues until lugs 55 on the top panel of the outer 31 contact projections 49 on the indexing disk. This entire rotation will have advanced the day disk 31 one indexing position with respect to the outer closure and indicia on the window 66 of the outer 31 will have been advanced one position.
During application and removal of the closure 30 from the container 34 the angular motion of the lugs 55 on the outer closure moves through a predetermined angle as they contact the projections 49 on the indexing disk 38. For example, if there are 14 indexing positions, then are divides 350° by 14, or 25.7.
Therefore, the indicia should appear on the day disk 37 at 25.7°
intervals and the outer should rotate minimum of 25.7° each time a change in rotational direction takes place, for the closure 30 to advance one indexing position each time the closure 30 is rotated in the clockwise direction as it is being applied to the container 34.
It can thus be seen that there has been provided a child resistant closure which is reliable; which functions to repeatedly provide the desired information; which do not incorporate axial forces between the reminder components;
wherein the components are reversible so that the change in visible indicia can be made either as application or removal of the closure; which utilizes old and well known child resistant construction; and which can be manufactured readily in high-production.

Claims (9)

1.
A child resistant reminder closure comprising an outer closure member having a base wall and a peripheral skirt, an inner closure member having a base wall and a peripheral skirt, interengaging means between the outer closure member and inner closure member to retain the inner closure member against axially outward movement relative to the outer closure member, said outer closure member and said inner closure member having limited axial movement relative to each other, an assembly of a day disk and an indexing disk being rotatably mounted on said outer closure member, said day disk being provided adjacent the inner surface of the base wall of the outer closure member, said indexing disk being provided adjacent said day disk, said day disk having an opening and a first set of flexible radial ratcheting means extending radially inwardly into the opening from said day disk and a second set of flexible radial ratcheting means extending radially from the day disk in the same circumferential direction as the first set, said outer closure member having a first set of lugs adapted to engage said first set of flexible radial ratcheting means such that there is permissible rotational movement of the day disk relative to the outer closure in one circumferential direction, said indexing disk having a second set of lugs on the top surface engageable by said second set of flexible ratcheting means on said day disk such that there is permissible rotational movement of the day disk relative to the indexing disk in the opposite circumferential direction from that of permissible rotational movement of the day disk relative to the outer closure member, a set of rotationally interengageable means between said outer closure member and said indexing disk which are engaged when the outer closure member is rotated through a predetermined angle in either direction, a set of axially interengageable child resistant means between said indexing disk and said inner closure member, said day disk having circumferentially spaced indicia thereon, said base wall of said outer closure member having an opening adapted to be selectively aligned with said indicia, interengaging means on the inner closure member adapted to engage means on a container by relative rotation of said inner closure member and a container, such that when the outer closure member is moved axially toward the inner closure member and the outer closure member is rotated, the axially interengageable child resistant means between said indexing disk and said inner closure member become engaged and the closure can be removed or applied from the container by rotation of the outer closure member and such that said day disk can be rotated relative to said outer closure member during either said application or said removal of said disk to bring different indicia into view through said opening.
2.
The child resistant reminder closure set forth in claim 1 wherein said first set of flexible radial ratcheting means on said day disk comprise flexible fingers extending circumferentially in one direction and having free ends, said second of said set of flexible radial ratcheting means comprising a plurlaity of circumferentially extending flexible fingers extending circumferentially in the same direction as the first set of fingers, said first set being positioned on the opening in said day disk.
3.
The child resistant reminder closure set forth in claim 2 wherein said set of rotationally interengageable means between said outer closure member and said indexing disk comprises a third set of lugs on said outer closure member positioned at the juncture of the base wall and peripheral skirt of said outer closure member, said first set of lugs on said closure member engaging said first set of flexible fingers being positioned on the periphery of a cylindrical surface extending downwardly from the base wall of said outer closure member.
4.
The child resistant reminder closure set forth in claim 3 wherein said means on said indexing disk engageable with the second set of flexible fingers on said day disk comprise lugs on said indexing disk extending toward said base wall of said outer closure and having, recesses therein engaging the free ends of the second set of flexible fingers comprising the first set of ratcheting means.
5.
The child resistant reminder closure set forth in claim 4 wherein said set of axially interengageable child resistant means between said indexing disk and said inner closure member comprises a fourth set of lugs on the underside of said indexing disk and a fifth set of circumferentially spaced lugs on the top surface of said base wall of said inner closure member, said fourth set of lugs on the underside of the indexing disk being adapted to extend between the recesses of said fifth set of lugs on the inner closure member when the outer closure member is moved axially toward the inner closure member and to engage the fourth set of lugs on the inner closure member when the outer closure member is rotated to apply or remove the closure from a container.
6.
The child resistant reminder closure set forth in any one of claim 1-5 wherein said flexible ratcheting means on said day disk extend circumferentially such that said day disk is rotated relative to said outer closure member on removal of the closure.
7.
The child resistant reminder closure set forth in any one of claims 1-5 wherein said flexible ratcheting means on said day disk extend circumferentially such that said day disk is rotated relative to said outer closure member on application of the closure.
8.
The child resistant reminder closure set forth in any one of claims 4-7 wherein the thickness of the day disk in an axial direction is less than the axial height of said second set of lugs on the indexing disk which extends toward the outer closure member and less than the axial height of said third set of lugs located at the juncture of the base wall and skirt of the outer closure member.
9.
The child resistant reminder closure set forth in claim 1 comprising means on said outer closure member for holding said assembly of said day disk and indexing disk against axially outward movement relative to said outer closure member.
CA002093868A 1992-05-05 1993-04-13 Child resistant reminder closure Expired - Fee Related CA2093868C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/878,647 US5184739A (en) 1992-05-05 1992-05-05 Child resistant reminder closure
US07/878,647 1992-05-05

Publications (2)

Publication Number Publication Date
CA2093868A1 CA2093868A1 (en) 1993-11-06
CA2093868C true CA2093868C (en) 2004-03-09

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Family Applications (1)

Application Number Title Priority Date Filing Date
CA002093868A Expired - Fee Related CA2093868C (en) 1992-05-05 1993-04-13 Child resistant reminder closure

Country Status (9)

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US (2) US5184739A (en)
EP (1) EP0569170B1 (en)
JP (1) JPH0741931B2 (en)
AT (1) ATE139506T1 (en)
AU (1) AU656850B2 (en)
CA (1) CA2093868C (en)
DE (1) DE69303228D1 (en)
MX (1) MX9302352A (en)
ZA (2) ZA932802B (en)

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DE69303228D1 (en) 1996-07-25
AU656850B2 (en) 1995-02-16
JPH0741931B2 (en) 1995-05-10
ZA932803B (en) 1993-11-16
JPH0632364A (en) 1994-02-08
US5184739A (en) 1993-02-09
ATE139506T1 (en) 1996-07-15
USRE34930E (en) 1995-05-09
AU3692093A (en) 1993-11-11
MX9302352A (en) 1993-11-01
ZA932802B (en) 1994-02-21
EP0569170A1 (en) 1993-11-10
EP0569170B1 (en) 1996-06-19
CA2093868A1 (en) 1993-11-06

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