CA2162922A1 - Diagnosis of dysplasia using laser induced fluorescence - Google Patents

Diagnosis of dysplasia using laser induced fluorescence

Info

Publication number
CA2162922A1
CA2162922A1 CA002162922A CA2162922A CA2162922A1 CA 2162922 A1 CA2162922 A1 CA 2162922A1 CA 002162922 A CA002162922 A CA 002162922A CA 2162922 A CA2162922 A CA 2162922A CA 2162922 A1 CA2162922 A1 CA 2162922A1
Authority
CA
Canada
Prior art keywords
fluorescence intensity
peak
normal
tissue
diagnostic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002162922A
Other languages
French (fr)
Other versions
CA2162922C (en
Inventor
Nirmala Ramanujam
Anita Mahadevan
Rebecca Richards-Kortum
Michele Follen Mitchell
Sharon Thomsen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Texas System
Original Assignee
Nirmala Ramanujam
Anita Mahadevan
Rebecca Richards-Kortum
Michele Follen Mitchell
Sharon Thomsen
Board Of Regents, The University Of Texas System
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nirmala Ramanujam, Anita Mahadevan, Rebecca Richards-Kortum, Michele Follen Mitchell, Sharon Thomsen, Board Of Regents, The University Of Texas System filed Critical Nirmala Ramanujam
Publication of CA2162922A1 publication Critical patent/CA2162922A1/en
Application granted granted Critical
Publication of CA2162922C publication Critical patent/CA2162922C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0082—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes
    • A61B5/0084—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for introduction into the body, e.g. by catheters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0071—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by measuring fluorescence emission
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0075—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/43—Detecting, measuring or recording for evaluating the reproductive systems
    • A61B5/4306—Detecting, measuring or recording for evaluating the reproductive systems for evaluating the female reproductive systems, e.g. gynaecological evaluations
    • A61B5/4318—Evaluation of the lower reproductive system
    • A61B5/4331—Evaluation of the lower reproductive system of the cervix
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6402—Atomic fluorescence; Laser induced fluorescence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N2021/6417—Spectrofluorimetric devices

Abstract

Apparatus and in vivo methods for distinguishing normal and abnormal cervical tissue and detecting cervical intraepithelial neo-plasia (CIN) in a diagnostic tissue sample. A source of electromagnetic radiation (36) is applied to the diagnostic cervical tissue sample and the presumptively known normal cervical tissue. Fluorescence intensity spectra induced in the diagnostic tissue sample and the presumptively known tissue by the radiation source is detected by at least one radiation detector (26).
A computer (20) is programmed to measure a peak normal fluorescence intensity value in each of the normal fluorescence intensity spectra, to calculate an average peak normal fluorescence intensity from the peak normal fluorescence intensity values, to measure a peak fluorescence intensity value from the fluorescence intensity spectrum induced in the diagnostic tissue sample, to calculate a slope parameter which is indicative of tissue abnormality, to calculate relative peak fluorescence intensity as a function of the peak intensity value, the average peak normal intensity, and to detect tissue abnormality as a function of the slope parameter and the relative peak fluorescence intensity.
CA002162922A 1993-05-12 1994-05-11 Diagnosis of dysplasia using laser induced fluorescence Expired - Fee Related CA2162922C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/060,432 1993-05-12
US08/060,432 US5421339A (en) 1993-05-12 1993-05-12 Diagnosis of dysplasia using laser induced fluoroescence
PCT/US1994/005230 WO1994026168A1 (en) 1993-05-12 1994-05-11 Diagnosis of dysplasia using laser induced fluorescence

Publications (2)

Publication Number Publication Date
CA2162922A1 true CA2162922A1 (en) 1994-11-24
CA2162922C CA2162922C (en) 2004-10-26

Family

ID=22029443

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002162922A Expired - Fee Related CA2162922C (en) 1993-05-12 1994-05-11 Diagnosis of dysplasia using laser induced fluorescence

Country Status (7)

Country Link
US (2) US5421339A (en)
EP (1) EP0702526B1 (en)
JP (1) JP3753186B2 (en)
AU (1) AU6946894A (en)
CA (1) CA2162922C (en)
DE (1) DE69432516T2 (en)
WO (1) WO1994026168A1 (en)

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AU6946894A (en) 1994-12-12
US5421339A (en) 1995-06-06
DE69432516T2 (en) 2004-01-29
EP0702526A1 (en) 1996-03-27
EP0702526B1 (en) 2003-04-16
WO1994026168A1 (en) 1994-11-24
DE69432516D1 (en) 2003-05-22
US5623932A (en) 1997-04-29
JP3753186B2 (en) 2006-03-08
JPH08511179A (en) 1996-11-26
EP0702526A4 (en) 1998-08-05
CA2162922C (en) 2004-10-26

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