CA2221513A1 - Fluorochemical liquid augmented cryosurgery - Google Patents

Fluorochemical liquid augmented cryosurgery

Info

Publication number
CA2221513A1
CA2221513A1 CA002221513A CA2221513A CA2221513A1 CA 2221513 A1 CA2221513 A1 CA 2221513A1 CA 002221513 A CA002221513 A CA 002221513A CA 2221513 A CA2221513 A CA 2221513A CA 2221513 A1 CA2221513 A1 CA 2221513A1
Authority
CA
Canada
Prior art keywords
lesion
fluoro
chemical liquid
liquid
around
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002221513A
Other languages
French (fr)
Other versions
CA2221513C (en
Inventor
Robert G. Stern
Thomas H. Shaffer
Marla R. Wolfson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Temple University of Commonwealth System of Higher Education
Original Assignee
Temple University - Of The Commonwealth System Of Higher Education
Robert G. Stern
Thomas H. Shaffer
Marla R. Wolfson
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Temple University - Of The Commonwealth System Of Higher Education, Robert G. Stern, Thomas H. Shaffer, Marla R. Wolfson filed Critical Temple University - Of The Commonwealth System Of Higher Education
Publication of CA2221513A1 publication Critical patent/CA2221513A1/en
Application granted granted Critical
Publication of CA2221513C publication Critical patent/CA2221513C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/02—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by cooling, e.g. cryogenic techniques
    • A61B18/0218—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by cooling, e.g. cryogenic techniques with open-end cryogenic probe, e.g. for spraying fluid directly on tissue or via a tissue-contacting porous tip
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/02—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by cooling, e.g. cryogenic techniques
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00053—Mechanical features of the instrument of device
    • A61B2018/00059—Material properties
    • A61B2018/00089—Thermal conductivity
    • A61B2018/00101—Thermal conductivity low, i.e. thermally insulating
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00053—Mechanical features of the instrument of device
    • A61B2018/00214—Expandable means emitting energy, e.g. by elements carried thereon
    • A61B2018/0022—Balloons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/02—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by cooling, e.g. cryogenic techniques
    • A61B2018/0212—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by cooling, e.g. cryogenic techniques using an instrument inserted into a body lumen, e.g. catheter
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/36—Image-producing devices or illumination devices not otherwise provided for
    • A61B90/37—Surgical systems with images on a monitor during operation
    • A61B2090/378—Surgical systems with images on a monitor during operation using ultrasound
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/39—Markers, e.g. radio-opaque or breast lesions markers
    • A61B2090/3925—Markers, e.g. radio-opaque or breast lesions markers ultrasonic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/39—Markers, e.g. radio-opaque or breast lesions markers
    • A61B2090/3933—Liquid markers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2218/00—Details of surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2218/001—Details of surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body having means for irrigation and/or aspiration of substances to and/or from the surgical site
    • A61B2218/002—Irrigation

Abstract

This invention is a method for cryogenic treatment of a lesion (20) which comprises the steps of delivering a fluoro-chemical liquid to the lesion (20), placing at least one cryoprobe (26) into the lesion (20), and circulating a cryogenic fluid causing an ice ball (30) to form in a vicinity around the cryoprobe (26), wherein the ice ball (30) obliterates at least a portion of the lesion (20). The fluoro-chemical liquid is utilized to augment the cryosurgical procedure and is perfused or injected into and/or around the lesion site prior and/or during the application of a cryprobe (26) to the site. In one embodiment of the invention, the fluoro-chemical liquid acts as a contrast agent to enhance real time medical imaging of the lesion area and modifies the environment in and around the lesion area. In another embodiment of the invention, the fluoro-chemical liquid augments cryosurgical procedures by controlling the size and shape of ice balls (30) formed during the cryosurgical procedures. In this embodiment, a fluoro-chemical liquid with a properly chosen thermal conductivity and freezing point is utilized. Depending on the thermal properties chosen, the liquid either augments freezing of the target area and/or promotes thermal conduction to freeze larger areas, or limits the freezing of the target area and reduces thermal conduction. In an non-cryoprobe embodiment, the liquid is cooled to a temperature below the freezing point of the biological tissue. The cooled liquid is then infused into or around the cystic lesion to produce ablation.
CA002221513A 1995-06-07 1996-05-21 Fluorochemical liquid augmented cryosurgery Expired - Lifetime CA2221513C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/487,386 US5741248A (en) 1995-06-07 1995-06-07 Fluorochemical liquid augmented cryosurgery
US08/487,386 1995-06-07
PCT/US1996/007599 WO1996039960A1 (en) 1995-06-07 1996-05-21 Fluorochemical liquid augmented cryosurgery

Publications (2)

Publication Number Publication Date
CA2221513A1 true CA2221513A1 (en) 1996-12-19
CA2221513C CA2221513C (en) 2009-01-27

Family

ID=23935530

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002221513A Expired - Lifetime CA2221513C (en) 1995-06-07 1996-05-21 Fluorochemical liquid augmented cryosurgery

Country Status (9)

Country Link
US (1) US5741248A (en)
EP (1) EP0835078B1 (en)
JP (1) JP4155597B2 (en)
AT (1) ATE290343T1 (en)
AU (1) AU5875196A (en)
CA (1) CA2221513C (en)
DE (1) DE69634435T2 (en)
ES (1) ES2235188T3 (en)
WO (1) WO1996039960A1 (en)

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