CA2248321A1 - Condensate colorimetric nitrogen oxide analyzer - Google Patents

Condensate colorimetric nitrogen oxide analyzer

Info

Publication number
CA2248321A1
CA2248321A1 CA002248321A CA2248321A CA2248321A1 CA 2248321 A1 CA2248321 A1 CA 2248321A1 CA 002248321 A CA002248321 A CA 002248321A CA 2248321 A CA2248321 A CA 2248321A CA 2248321 A1 CA2248321 A1 CA 2248321A1
Authority
CA
Canada
Prior art keywords
reagent
exhaling
inlet
condensate
chamber
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002248321A
Other languages
French (fr)
Other versions
CA2248321C (en
Inventor
Benjamin M. Gaston, Iv
John F. Hunt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nitromed Inc
Original Assignee
Benjamin M. Gaston, Iv
John F. Hunt
Nitromed, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Benjamin M. Gaston, Iv, John F. Hunt, Nitromed, Inc. filed Critical Benjamin M. Gaston, Iv
Publication of CA2248321A1 publication Critical patent/CA2248321A1/en
Application granted granted Critical
Publication of CA2248321C publication Critical patent/CA2248321C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/08Detecting, measuring or recording devices for evaluating the respiratory organs
    • A61B5/083Measuring rate of metabolism by using breath test, e.g. measuring rate of oxygen consumption

Abstract

Disclosed is a device for determination of the content of higher oxides of nitrogen in exhaled breath condensate which comprises a conduit (7) having an exhaling condensing portion with an inlet and an outlet (the inlet can be configured to fit with a mechanical respirator, or for direct use by a patient, an inlet assembly providing one-way ingress (2) of ambient atmosphere so the device can be associated with the inlet of the conduit exhaling condensing portion); a coolant jacket (6) coaxially surrounding said exhaling condensing portion; a gas release port; and, in an enclosed fluid communication with said conduit exhaling condensing portion outlet, a sample assay assembly (9) comprising the following: (a) a translucent analysis chamber attached to the outlet to receive condensate fluid and having a reagent port;
(b) a reagent chamber in enclosed fluid communication with the reagent entry port; and (c) a pliable element connecting the oulet and the analysis chamber and forming a portion of the reagent chamber such that flexion of the pliable element closes communication between the owlet and the analysis chamber and contracts the reagent chamber so as to deliver to the analysis chamber controlled amounts of condensate and reagent. The device is disposable and-inexpensive, and is used to collect human exhaling for colorimetric assay of liquid and gas phase nitrogen oxides to assist in evaluation of airway inflammation.
CA002248321A 1996-03-28 1997-03-25 Condensate colorimetric nitrogen oxide analyzer Expired - Fee Related CA2248321C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/623,643 1996-03-28
US08/623,643 US6033368A (en) 1996-03-28 1996-03-28 Condensate colorimetric nitrogen oxide analyzer
PCT/US1997/004848 WO1997035519A1 (en) 1996-03-28 1997-03-25 Condensate colorimetric nitrogen oxide analyzer

Publications (2)

Publication Number Publication Date
CA2248321A1 true CA2248321A1 (en) 1997-10-02
CA2248321C CA2248321C (en) 2003-03-18

Family

ID=24498874

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002248321A Expired - Fee Related CA2248321C (en) 1996-03-28 1997-03-25 Condensate colorimetric nitrogen oxide analyzer

Country Status (6)

Country Link
US (2) US6033368A (en)
EP (1) EP0897284A4 (en)
JP (1) JP2000507462A (en)
AU (1) AU724417B2 (en)
CA (1) CA2248321C (en)
WO (1) WO1997035519A1 (en)

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Also Published As

Publication number Publication date
JP2000507462A (en) 2000-06-20
EP0897284A1 (en) 1999-02-24
CA2248321C (en) 2003-03-18
WO1997035519A1 (en) 1997-10-02
AU2346197A (en) 1997-10-17
AU724417B2 (en) 2000-09-21
US6033368A (en) 2000-03-07
US6419634B1 (en) 2002-07-16
EP0897284A4 (en) 1999-05-19

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