CA2261760A1 - Sulfonamides and derivatives thereof that modulate the activity of endothelin - Google Patents
Sulfonamides and derivatives thereof that modulate the activity of endothelinInfo
- Publication number
- CA2261760A1 CA2261760A1 CA002261760A CA2261760A CA2261760A1 CA 2261760 A1 CA2261760 A1 CA 2261760A1 CA 002261760 A CA002261760 A CA 002261760A CA 2261760 A CA2261760 A CA 2261760A CA 2261760 A1 CA2261760 A1 CA 2261760A1
- Authority
- CA
- Canada
- Prior art keywords
- endothelin
- sulfonamides
- activity
- isoxazolyl
- methods
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D419/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms
- C07D419/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D419/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pulmonology (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Rheumatology (AREA)
- Ophthalmology & Optometry (AREA)
- Pain & Pain Management (AREA)
- Reproductive Health (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
Thienyl-, furyl- and pyrrolyl-sulfonamides, formulations of pharmaceutically acceptable salts thereof and methods for modulating or altering the activity of the endothelin family of peptides are provided. In particular, N-(isoxazolyl)thienylsulfonamides, N-(isoxazolyl)furylsulfonamides and N-(isoxazolyl)pyrrolylsulfonamides, formulations thereof and methods using these sulfonamides for inhibiting the binding of an endothelin peptide to an endothelin receptor by contacting the receptor with the sulfonamide are provided.
Methods for treating endothelin-mediated disorders by administering effective amounts of one or more of these sulfonamides or prodrugs thereof that inhibit the activity of the endothelin are also provided.
Methods for treating endothelin-mediated disorders by administering effective amounts of one or more of these sulfonamides or prodrugs thereof that inhibit the activity of the endothelin are also provided.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/721,183 | 1996-09-27 | ||
US08/721,183 US5962490A (en) | 1987-09-25 | 1996-09-27 | Thienyl-, furyl- and pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin |
PCT/US1997/017402 WO1998013366A1 (en) | 1996-09-27 | 1997-09-26 | Sulfonamides and derivatives thereof that modulate the activity of endothelin |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2261760A1 true CA2261760A1 (en) | 1998-04-02 |
CA2261760C CA2261760C (en) | 2005-03-29 |
Family
ID=24896894
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002261760A Expired - Lifetime CA2261760C (en) | 1996-09-27 | 1997-09-26 | Sulfonamides and derivatives thereof that modulate the activity of endothelin |
Country Status (23)
Country | Link |
---|---|
US (5) | US5962490A (en) |
EP (2) | EP1342721A1 (en) |
JP (2) | JP3743520B2 (en) |
KR (1) | KR100372195B1 (en) |
CN (2) | CN100558724C (en) |
AP (1) | AP9901471A0 (en) |
AT (1) | ATE270669T1 (en) |
AU (1) | AU736269B2 (en) |
BR (1) | BR9711550A (en) |
CA (1) | CA2261760C (en) |
CZ (1) | CZ85499A3 (en) |
DE (1) | DE69729803T2 (en) |
EA (2) | EA200300824A1 (en) |
ES (1) | ES2224271T3 (en) |
IL (1) | IL128145A0 (en) |
NO (1) | NO991388L (en) |
NZ (1) | NZ334797A (en) |
OA (1) | OA11024A (en) |
PL (1) | PL332323A1 (en) |
PT (1) | PT946552E (en) |
SK (1) | SK36599A3 (en) |
TR (1) | TR199900705T2 (en) |
WO (1) | WO1998013366A1 (en) |
Families Citing this family (72)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5962490A (en) | 1987-09-25 | 1999-10-05 | Texas Biotechnology Corporation | Thienyl-, furyl- and pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin |
US6541498B2 (en) | 1993-05-20 | 2003-04-01 | Texas Biotechnology | Benzenesulfonamides and the use thereof to modulate the activity of endothelin |
US6342610B2 (en) | 1993-05-20 | 2002-01-29 | Texas Biotechnology Corp. | N-aryl thienyl-, furyl-, and pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin |
US6613804B2 (en) | 1993-05-20 | 2003-09-02 | Encysive Pharmaceuticals, Inc. | Biphenylsulfonamides and derivatives thereof that modulate the activity of endothelin |
US6376523B1 (en) | 1994-05-20 | 2002-04-23 | Texas Biotechnology Corporation | Benzenesulfonamides and the use thereof to modulate the activity of endothelin |
US5977117A (en) | 1996-01-05 | 1999-11-02 | Texas Biotechnology Corporation | Substituted phenyl compounds and derivatives thereof that modulate the activity of endothelin |
US5958905A (en) | 1996-03-26 | 1999-09-28 | Texas Biotechnology Corporation | Phosphoramidates, phosphinic amides and related compounds and the use thereof to modulate the activity of endothelin |
US5804585A (en) | 1996-04-15 | 1998-09-08 | Texas Biotechnology Corporation | Thieno-pyridine sulfonamides derivatives thereof and related compounds that modulate the activity of endothelin |
IL131318A (en) | 1997-04-28 | 2004-08-31 | Encysive Pharmaceuticals Inc | Pharmaceutically acceptable salts of sulfonamides for treatment of endothelin-mediated disorders |
US5783705A (en) | 1997-04-28 | 1998-07-21 | Texas Biotechnology Corporation | Process of preparing alkali metal salys of hydrophobic sulfonamides |
EP1533311B1 (en) * | 1999-12-31 | 2007-04-25 | Encysive Pharmaceuticals, Inc | Sulfonamides and derivatives thereof that modulate the activity of endothelin |
ATE286051T1 (en) | 1999-12-31 | 2005-01-15 | Encysive Pharmaceuticals Inc | SULFONAMIDES AND THEIR DERIVATIVES THAT MODULATE THE ACTIVITY OF ENDOTHELIN |
SE0001899D0 (en) * | 2000-05-22 | 2000-05-22 | Pharmacia & Upjohn Ab | New compounds |
EP1347051A4 (en) * | 2000-12-26 | 2004-05-26 | Genox Research Inc | Method of examining allergic disease |
ES2185606T3 (en) * | 2001-03-21 | 2003-05-01 | Sanol Arznei Schwarz Gmbh | NEW USE OF A CLASS OF PEPTIDIC COMPOUNDS FOR TREATMENT OF ALLODINIA OR OTHER DIFFERENT TYPES OF CHRONIC OR GHOST PAIN. |
US20030176356A1 (en) * | 2001-04-24 | 2003-09-18 | University Of North Texas Health Science Center | Endothelin antagonists and endothelin-converting enzyme inhibitors for the treatment of glaucoma |
US20030130279A1 (en) * | 2001-11-22 | 2003-07-10 | Guido Kurz | Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1 |
EA200400707A1 (en) * | 2001-11-22 | 2004-10-28 | Биовитрум Аб | INHIBITORS 11-BETA-HYDROXYSTEROID DEGYDROGENASE TYPE 1 |
EA200400708A1 (en) * | 2001-11-22 | 2004-10-28 | Биовитрум Аб | INHIBITORS 11-BETA-HYDROXYSTEROID DEGYDROGENASE TYPE 1 |
IL160648A0 (en) * | 2001-11-22 | 2004-07-25 | Biovitrum Ab | Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1 |
WO2003051870A1 (en) * | 2001-12-18 | 2003-06-26 | Astrazeneca Ab | Novel compounds |
TWI328007B (en) | 2002-01-16 | 2010-08-01 | Astrazeneca Ab | Novel compounds |
SG143986A1 (en) * | 2002-06-11 | 2008-07-29 | Wyeth Corp | Substituted phenylsulfonamide inhibitors of beta amyloid production |
WO2004014300A2 (en) * | 2002-08-09 | 2004-02-19 | Merck & Co., Inc. | Tyrosine kinase inhibitors |
US20040102360A1 (en) * | 2002-10-30 | 2004-05-27 | Barnett Stanley F. | Combination therapy |
EP2415760A3 (en) * | 2003-02-20 | 2012-02-22 | Encysive Pharmaceuticals, Inc. | CCR-9 antagonists |
US7288538B2 (en) * | 2003-02-20 | 2007-10-30 | Encysive Pharmaceuticals, Inc. | Phenylenediamine urotensin-II receptor antagonists and CCR-9 antagonists |
US7790724B2 (en) * | 2003-04-25 | 2010-09-07 | Janssen Pharmaceutica N.V. | c-fms kinase inhibitors |
US7427683B2 (en) * | 2003-04-25 | 2008-09-23 | Ortho-Mcneil Pharmaceutical, Inc. | c-fms kinase inhibitors |
JP2007525460A (en) * | 2003-04-25 | 2007-09-06 | オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド | c-fms kinase inhibitor |
US20050113566A1 (en) * | 2003-04-25 | 2005-05-26 | Player Mark R. | Inhibitors of C-FMS kinase |
SE0301650D0 (en) * | 2003-06-04 | 2003-06-04 | Astrazeneca Ab | Novel compounds |
SE0301653D0 (en) * | 2003-06-05 | 2003-06-05 | Astrazeneca Ab | Novel compounds |
SE0301654D0 (en) * | 2003-06-05 | 2003-06-05 | Astrazeneca Ab | Novel compounds |
ES2325995T3 (en) * | 2003-12-02 | 2009-09-28 | Schwarz Pharma Ag | NEW USE OF PEPTIDIC COMPOUNDS FOR TREATMENT OF CENTRAL NEUROPATHIC PAIN. |
US20070042969A1 (en) * | 2004-03-26 | 2007-02-22 | Srz Properties, Inc. | Combination therapy for pain in painful diabetic neuropathy |
US20100256179A1 (en) * | 2004-03-26 | 2010-10-07 | Ucb Pharma Gmbh | Combination therapy for pain in painful diabetic neuropathy |
EP1604655A1 (en) | 2004-06-09 | 2005-12-14 | Schwarz Pharma Ag | Novel use of peptide compounds for treating pain in trigeminal neuralgia |
DE102005005397B4 (en) * | 2005-02-05 | 2008-08-21 | Lts Lohmann Therapie-Systeme Ag | Isolation of N-butylbenzenesulfonamide, synthesis of benzenesulfonamide derivatives, and use of N-butylbenzenesulfonamide and benzenesulfonamide derivatives for the treatment of benign prostatic hyperplasia and / or prostate carcinoma |
EP1754476A1 (en) * | 2005-08-18 | 2007-02-21 | Schwarz Pharma Ag | Lacosamide (SPM 927) for treating myalgia, e.g. fibromyalgia |
US20070043120A1 (en) * | 2005-08-18 | 2007-02-22 | Bettina Beyreuther | Therapeutic combination for painful medical conditions |
JP5204662B2 (en) * | 2005-11-22 | 2013-06-05 | アムジエン・インコーポレーテツド | Inhibitors of 11-β-hydroxysteroid dehydrogenase type 1 |
TW200730512A (en) * | 2005-12-12 | 2007-08-16 | Astrazeneca Ab | Novel compounds |
AU2007221495B2 (en) * | 2006-03-03 | 2011-09-15 | Torrent Pharmaceuticals Ltd. | Novel dual action receptors antagonists (DARA) at the AT1 and ETA receptors |
WO2007106494A2 (en) * | 2006-03-13 | 2007-09-20 | Encysive Pharmaceuticals, Inc. | Methods and compositions for treatment of diastolic heart failure |
EP2001446A2 (en) * | 2006-03-13 | 2008-12-17 | Encysive Pharmaceuticals, Inc | Formulations of sitaxsentan sodium |
EA027836B1 (en) * | 2006-06-15 | 2017-09-29 | ЮСиБи ФАРМА ГМБХ | Pharmaceutical combination for prevention, alleviation and/or treatment of epileptic seizures and use thereof |
US20080026061A1 (en) * | 2006-06-22 | 2008-01-31 | Reichwein John F | Crystalline N-(4-chloro-3-methyl-5-isoxazolyl)-2-[2-methyl-4.5-(methylenedioxy)phenylacetyl]-thiophene-3-sulfonamide |
JP5259592B2 (en) * | 2006-08-11 | 2013-08-07 | メルク カナダ インコーポレイテッド | Thiophenecarboxamide derivatives as EP4 receptor ligands |
JP4891111B2 (en) * | 2007-02-16 | 2012-03-07 | 富士フイルム株式会社 | Zoom lens |
US9298721B2 (en) * | 2007-02-28 | 2016-03-29 | Qualcomm Incorporated | Prioritized search results based on monitored data |
CL2008000835A1 (en) | 2007-03-23 | 2008-10-03 | Icagen Inc Pfizer Ltd | COMPOUNDS DERIVED FROM SULFONAMIDS, INHIBITORS OF THE CALCIUM CHANNELS; PHARMACEUTICAL COMPOSITION THAT INCLUDES SUCH COMPOUND; AND USE OF THE COMPOUND FOR THE TREATMENT OF PAIN, IRRITABLE INTESTINE SYNDROME, CROHN DISEASE, TAQUIARRITM |
EP2344453B1 (en) * | 2008-10-09 | 2016-12-28 | The U.S.A. As Represented By The Secretary, Department Of Health And Human Services | Activators of human pyruvate kinase |
EP2417123A2 (en) | 2009-04-06 | 2012-02-15 | Agios Pharmaceuticals, Inc. | Therapeutic compositions and related methods of use |
DK2427441T3 (en) | 2009-05-04 | 2017-03-20 | Agios Pharmaceuticals Inc | PKM2 Activators for use in the treatment of cancer |
ES2618630T3 (en) | 2009-06-29 | 2017-06-21 | Agios Pharmaceuticals, Inc. | Therapeutic compositions and related methods of use |
EP2448582B1 (en) | 2009-06-29 | 2017-04-19 | Agios Pharmaceuticals, Inc. | Quinoline-8-sulfonamide derivatives having an anticancer activity |
CA2797694A1 (en) | 2010-04-29 | 2011-11-03 | The United States Of America, As Represented By The Secretary, Departmen T Of Health And Human Services | Activators of human pyruvate kinase |
MX2013006900A (en) | 2010-12-17 | 2013-10-17 | Agios Pharmaceuticals Inc | Novel n- (4- (azetidine - 1 - carbonyl) phenyl) - (hetero - ) arylsulfonamide derivatives as pyruvate kinase m2 (pmk2) modulators. |
CA2822432C (en) | 2010-12-21 | 2019-09-24 | Agios Pharmaceuticals, Inc. | Bicyclic pkm2 activators |
TWI549947B (en) | 2010-12-29 | 2016-09-21 | 阿吉歐斯製藥公司 | Therapeutic compounds and compositions |
EP2511263A1 (en) | 2011-04-14 | 2012-10-17 | Phenex Pharmaceuticals AG | Pyrrolo sulfonamide compounds for modulation of orphan nuclear receptor RAR-related orphan receptor-gamma (RORgamma, NR1F3) activity and for the treatment of chronic inflammatory and autoimmune diseases |
HUE039269T2 (en) | 2011-05-03 | 2018-12-28 | Agios Pharmaceuticals Inc | Pyruvate kinase activators for use in therapy |
US11234976B2 (en) | 2015-06-11 | 2022-02-01 | Agios Pharmaceuticals, Inc. | Methods of using pyruvate kinase activators |
WO2017184604A1 (en) * | 2016-04-18 | 2017-10-26 | Ifm Therapeutics, Inc | Compounds and compositions for treating conditions associated with nlrp activity |
EP3241874B1 (en) | 2016-05-04 | 2019-08-14 | Agfa Nv | Acylphosphine oxide photoinitiators |
US20180187263A1 (en) | 2017-01-05 | 2018-07-05 | Iowa State University Research Foundation, Inc. | Kits for diagnostic detection and prevention of feedlot bovine respiratory disease |
GB201810581D0 (en) | 2018-06-28 | 2018-08-15 | Ctxt Pty Ltd | Compounds |
CA3121202A1 (en) | 2018-11-30 | 2020-06-04 | Nuvation Bio Inc. | Pyrrole and pyrazole compounds and methods of use thereof |
SG11202110406SA (en) * | 2019-04-11 | 2021-10-28 | Angion Biomedica Corp | Solid forms of (e)-3-[2-(2-thienyl)vinyl]-1h-pyrazole |
KR20220024671A (en) | 2019-06-18 | 2022-03-03 | 화이자 인코포레이티드 | Benzisoxazole sulfonamide derivatives |
WO2022270487A1 (en) | 2021-06-22 | 2022-12-29 | 株式会社アークメディスン | Compound, endothelin-a receptor antagonist, and pharmaceutical composition |
Family Cites Families (129)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US91270A (en) * | 1869-06-15 | Henry hi ohm ann | ||
GB804036A (en) * | 1956-03-02 | 1958-11-05 | Hoffmann La Roche | A process for the manufacture of a sulphanilamide of the isoxazole series |
US2888455A (en) * | 1956-09-04 | 1959-05-26 | Shionogi & Co | New sulfonamide and process for producing the same |
US3300488A (en) * | 1963-12-23 | 1967-01-24 | Shionogi & Co | Nu, nu'-bis [4-halogenated-5-alkyl-3-isoxazolylsulfamoyl)-phenyl]-ureas |
US3660383A (en) * | 1968-08-14 | 1972-05-02 | Shionogi & Co | Production of iodoisoxazole compounds |
US3710795A (en) | 1970-09-29 | 1973-01-16 | Alza Corp | Drug-delivery device with stretched, rate-controlling membrane |
US4044126A (en) * | 1972-04-20 | 1977-08-23 | Allen & Hanburys Limited | Steroidal aerosol compositions and process for the preparation thereof |
GB1429184A (en) * | 1972-04-20 | 1976-03-24 | Allen & Hanburys Ltd | Physically anti-inflammatory steroids for use in aerosols |
US3821087A (en) | 1972-05-18 | 1974-06-28 | Dedrick R | Cell culture on semi-permeable tubular membranes |
US3883393A (en) | 1972-05-18 | 1975-05-13 | Us Health Education & Welfare | Cell culture on semi-permeable tubular membranes |
USRE28819E (en) | 1972-12-08 | 1976-05-18 | Syntex (U.S.A.) Inc. | Dialkylated glycol compositions and medicament preparations containing same |
GB1473433A (en) * | 1975-10-09 | 1977-05-11 | Banyu Pharmaceutical Co Ltd Hi | |
FR2395271A1 (en) | 1977-06-21 | 1979-01-19 | Parcor | PROCESS FOR THE PREPARATION OF THIENO (2,3-C) AND THIENO (3,2-C) PYRIDINES |
US4191554A (en) | 1977-10-03 | 1980-03-04 | E. I. Du Pont De Nemours And Company | Herbicidal benzamides |
US4375544A (en) | 1978-01-28 | 1983-03-01 | Croda Synthetic Chemicals Limited | Fused pyridines |
FR2471983A1 (en) | 1979-12-20 | 1981-06-26 | Sanofi Sa | PROCESS FOR THE CATALYTIC PREPARATION OF THIENO (3,2-C) PYRIDINE |
US4410545A (en) | 1981-02-13 | 1983-10-18 | Syntex (U.S.A.) Inc. | Carbonate diester solutions of PGE-type compounds |
US4328245A (en) | 1981-02-13 | 1982-05-04 | Syntex (U.S.A.) Inc. | Carbonate diester solutions of PGE-type compounds |
US4358603A (en) | 1981-04-16 | 1982-11-09 | Syntex (U.S.A.) Inc. | Acetal stabilized prostaglandin compositions |
US4577014A (en) | 1981-09-08 | 1986-03-18 | Eli Lilly And Company | Thieno and furopyridinium-substituted cephalosporins |
US4406898A (en) | 1981-09-08 | 1983-09-27 | Eli Lilly And Company | Oxazole and oxadiazole cephalosporins |
EP0076072B1 (en) * | 1981-09-24 | 1987-05-13 | BEECHAM - WUELFING GmbH & Co. KG | Sulphonamides |
US4409239A (en) | 1982-01-21 | 1983-10-11 | Syntex (U.S.A.) Inc. | Propylene glycol diester solutions of PGE-type compounds |
US4522811A (en) | 1982-07-08 | 1985-06-11 | Syntex (U.S.A.) Inc. | Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides |
JPS60188084A (en) | 1984-03-08 | 1985-09-25 | Otsuka Pharmaceut Factory Inc | Asterric acid derivative |
JPS6018808A (en) * | 1984-06-12 | 1985-01-30 | Matsushita Electric Ind Co Ltd | Magnetic head |
US4585773A (en) | 1984-07-11 | 1986-04-29 | Bristol-Myers Company | Isoindolinyl-alkyl-piperazines |
US4753672A (en) | 1985-07-16 | 1988-06-28 | E. I. Du Pont De Nemours And Company | Herbicidal acetals and ketals |
US4659369A (en) | 1984-08-27 | 1987-04-21 | E. I. Du Pont De Nemours And Company | Herbicidal acetals and ketals |
US4861366A (en) | 1984-08-27 | 1989-08-29 | E. I. Du Pont De Nemours And Company | Herbicidal acetals and ketals |
EP0194548A3 (en) * | 1985-03-12 | 1988-08-17 | Dr. Karl Thomae GmbH | Sulfonylaminoethyl compounds, medicines containing these compounds and process for their preparation |
US4914112A (en) | 1986-06-03 | 1990-04-03 | Sumitomo Pharmaceuticals Company, Limited | Aminoazole derivatives and their production and use |
US4763672A (en) * | 1986-12-16 | 1988-08-16 | Philip Morris Incorporated | Apparatus for injecting liquid-type material in the chimney of a cigarette maker |
JPS63238006A (en) | 1987-03-26 | 1988-10-04 | Shionogi & Co Ltd | Agent for controlling rice blast |
US4769371A (en) | 1987-05-01 | 1988-09-06 | E. R. Squibb & Sons, Inc. | Dihydropyrimidine carboxylic acid esters |
US4752613A (en) * | 1987-08-03 | 1988-06-21 | E. R. Squibb & Sons, Inc. | Sulphonamidothienylcarboxylic acid compounds |
US5514691A (en) * | 1993-05-20 | 1996-05-07 | Immunopharmaceutics, Inc. | N-(4-halo-isoxazolyl)-sulfonamides and derivatives thereof that modulate the activity of endothelin |
US5594021A (en) * | 1993-05-20 | 1997-01-14 | Texas Biotechnology Corporation | Thienyl-, furyl- and pyrrolyl sulfonamides and derivatives thereof that modulate the activity of endothelin |
US5591761A (en) | 1993-05-20 | 1997-01-07 | Texas Biotechnology Corporation | Thiophenyl-, furyl-and pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin |
US5962490A (en) * | 1987-09-25 | 1999-10-05 | Texas Biotechnology Corporation | Thienyl-, furyl- and pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin |
US5571821A (en) | 1993-05-20 | 1996-11-05 | Texas Biotechnology Corporation | Sulfonamides and derivatives thereof that modulate the activity of endothelin |
US5464853A (en) * | 1993-05-20 | 1995-11-07 | Immunopharmaceutics, Inc. | N-(5-isoxazolyl)biphenylsulfonamides, N-(3-isoxazolyl)biphenylsulfonamides and derivatives thereof that modulate the activity of endothelin |
US5033252A (en) | 1987-12-23 | 1991-07-23 | Entravision, Inc. | Method of packaging and sterilizing a pharmaceutical product |
US5052558A (en) | 1987-12-23 | 1991-10-01 | Entravision, Inc. | Packaged pharmaceutical product |
US5023090A (en) * | 1989-08-16 | 1991-06-11 | Levin Robert H | Topical compositions containing LYCD and other topically active medicinal ingredients for the treatment of ACNE |
US5231166A (en) | 1988-10-25 | 1993-07-27 | Takeda Chemical Industries, Ltd. | Endothelin |
US5246931A (en) | 1988-10-25 | 1993-09-21 | Bristol-Myers Squibb Company | Carbocyclic nucleoside analogs |
US4997836A (en) * | 1988-11-11 | 1991-03-05 | Takeda Chemical Industries, Ltd. | Trisubstituted piperazine compounds, their production and use |
WO1990009380A1 (en) | 1989-02-10 | 1990-08-23 | Otsuka Pharmaceutical Co., Ltd. | Indole derivatives, preparation thereof, and drug for preventing and treating nephritis containing same |
US5026700A (en) | 1989-05-16 | 1991-06-25 | Merrell Dow Pharmaceuticals | Certain quinolines and thienopyridines as excitatory amino acid antagonists |
US5082838A (en) | 1989-06-21 | 1992-01-21 | Takeda Chemical Industries, Ltd. | Sulfur-containing fused pyrimidine derivatives, their production and use |
JPH0347163A (en) | 1989-06-30 | 1991-02-28 | Fujisawa Pharmaceut Co Ltd | Anthraquinone derivative and production thereof |
US5230999A (en) * | 1989-07-24 | 1993-07-27 | Takeda Chemical Industries, Ltd. | Monoclonal antibody to endothelin-3 or precursor thereof and use thereof |
CA2032559C (en) | 1989-12-28 | 2001-11-06 | Kiyofumi Ishikawa | Endothelin antagonistic cyclic pentapeptides |
CA2079343A1 (en) | 1990-03-30 | 1991-10-01 | Eric E. Allen | Substituted pyrazoles, isoxazoles and isothiazoles |
US5284828A (en) | 1990-05-14 | 1994-02-08 | Fujisawa Pharmaceutical Co. Ltd. | Peptide compound and its preparation |
US5430022A (en) | 1990-05-14 | 1995-07-04 | Fujisawa Pharmaceutical Co., Ltd. | Peptide compound and its preparation |
CA2043741C (en) | 1990-06-07 | 2003-04-01 | Kiyofumi Ishikawa | Endothelin antagonistic peptide derivatives |
JPH04134084A (en) * | 1990-09-21 | 1992-05-07 | Tousou Sangyo Kk | Silicic acid ester and its production |
CA2056142A1 (en) * | 1990-11-27 | 1992-05-28 | Hirotomo Masuya | Pyridopyridazine compounds and their use |
CA2059380A1 (en) * | 1991-01-24 | 1992-07-25 | Yiu-Kuen T. Lam | Endothelin receptor antagonists isolated from microbispora |
DK0526642T3 (en) * | 1991-01-29 | 1998-10-19 | Shionogi & Co | triterpene derivative |
EP0569487A1 (en) | 1991-01-31 | 1993-11-18 | Abbott Laboratories | Endothelin converting enzyme inhibitors |
DK0498722T3 (en) | 1991-02-07 | 1998-03-09 | Roussel Uclaf | New bicyclic nitrogen compounds substituted with a benzyl group, process for their preparation, the novel intermediates obtained, their use as drugs and the pharmaceutical compositions contained in them. |
CA2061246A1 (en) * | 1991-02-15 | 1992-08-16 | Mitsuhiro Wakimasu | Peptides having antagonistic activities to endothelin receptors, production and use thereof |
CA2104860A1 (en) | 1991-03-08 | 1992-09-09 | Thomas T. Andersen | Endothelin antagonists |
TW270116B (en) * | 1991-04-25 | 1996-02-11 | Hoffmann La Roche | |
US5382569A (en) * | 1991-05-16 | 1995-01-17 | Warner-Lambert Company | Endotherlin antagonists |
RU2086544C1 (en) * | 1991-06-13 | 1997-08-10 | Хоффманн-Ля Рош АГ | Benzenesulfonamide derivatives of pyrimidine or their salts, pharmaceutical composition for treatment of diseases associated with endothelin activity |
US5260276A (en) | 1991-06-14 | 1993-11-09 | Warner-Lambert Company | Linear and monocyclic endothelin antagonists |
FR2679906B1 (en) * | 1991-07-31 | 1995-01-20 | Adir | NOVELS (ISOQUINOLEIN-5 YL) SULFONAMIDES, THEIR PREPARATION PROCESS AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM. |
GB2259450A (en) * | 1991-09-11 | 1993-03-17 | Fujisawa Pharmaceutical Co | Compositions with endothelin antagonist activity |
JP2667294B2 (en) * | 1991-11-05 | 1997-10-27 | スミスクライン・ビーチャム・コーポレイション | Endothelin receptor antagonist |
US5198548A (en) * | 1992-01-30 | 1993-03-30 | Warner-Lambert Company | Process for the preparation of D(-) and L(+)-3,3-diphenylalanine and D(-) and L(+)-substituted 3,3-diphenylalanines and derivatives thereof |
FR2687675B1 (en) * | 1992-01-31 | 1997-04-18 | Roussel Uclaf | NOVEL BICYCLIC PYRIDINE DERIVATIVES, PROCESS FOR THEIR PREPARATION, THE NEW INTERMEDIATES OBTAINED, THEIR APPLICATION AS MEDICAMENTS AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM. |
FR2687156B1 (en) | 1992-02-12 | 1994-04-01 | Roussel Uclaf | NOVEL PEPTIDE DERIVATIVES, PROCESS FOR THE PREPARATION AND APPLICATION AS MEDICAMENTS OF SUCH NEW DERIVATIVES. |
US5378715A (en) * | 1992-02-24 | 1995-01-03 | Bristol-Myers Squibb Co. | Sulfonamide endothelin antagonists |
TW224462B (en) * | 1992-02-24 | 1994-06-01 | Squibb & Sons Inc | |
LT3200B (en) * | 1992-03-18 | 1995-03-27 | Takeda Chemical Industries Ltd | Triazolopyridazine methodfor production thereof and use |
US5235045A (en) * | 1992-03-19 | 1993-08-10 | Microbiomed Corporation | Non-azo naphthalimide dyes |
US5240910A (en) * | 1992-04-17 | 1993-08-31 | Merck & Co., Inc. | Antihypertensive compounds produced by fermentation |
US5514696A (en) | 1992-05-06 | 1996-05-07 | Bristol-Myers Squibb Co. | Phenyl sulfonamide endothelin antagonists |
NZ247440A (en) * | 1992-05-06 | 1995-04-27 | Squibb & Sons Inc | Phenyl sulphonamide derivatives, preparation and pharmaceutical compositions thereof |
WO1993023404A1 (en) | 1992-05-19 | 1993-11-25 | Immunopharmaceutics, Inc. | Compounds that modulate endothelin activity |
ES2042421B1 (en) * | 1992-05-22 | 1994-08-01 | Uriach & Cia Sa J | PROCEDURE FOR OBTAINING 8-CHLORINE-11- * 1 - * (5-METHYL-3-PIRIDIL) METHYL * -4-PIPERIDILIDEN * -6,11-DIHYDRO-5H-BENZO * 5,6 * CYCLOHEPTA * 1 , 2-B * PIRIDINE. |
US5323907A (en) | 1992-06-23 | 1994-06-28 | Multi-Comp, Inc. | Child resistant package assembly for dispensing pharmaceutical medications |
IS2334B (en) * | 1992-09-08 | 2008-02-15 | Vertex Pharmaceuticals Inc., (A Massachusetts Corporation) | Aspartyl protease inhibitor of a new class of sulfonamides |
US5783701A (en) * | 1992-09-08 | 1998-07-21 | Vertex Pharmaceuticals, Incorporated | Sulfonamide inhibitors of aspartyl protease |
TW287160B (en) * | 1992-12-10 | 1996-10-01 | Hoffmann La Roche | |
US5420123A (en) * | 1992-12-21 | 1995-05-30 | Bristol-Myers Squibb Company | Dibenzodiazepine endothelin antagonists |
US5352800A (en) * | 1993-03-11 | 1994-10-04 | Merck & Co., Inc. | Process for the production of a novel endothelin antagonist |
US5565485A (en) * | 1993-03-19 | 1996-10-15 | Merck & Co., Inc. | Biphenyl compounds useful or endothelin antagonists |
US5420133A (en) * | 1993-03-19 | 1995-05-30 | Merck & Co., Inc. | Quinazolinones substituted with phenoxyphenylacetic acid derivatives |
US5334598A (en) * | 1993-03-19 | 1994-08-02 | Merck & Co., Inc. | Six-membered ring fused imidazoles substituted with phenoxyphenylacetic acid derivatives |
ES2062943B1 (en) * | 1993-03-23 | 1995-11-16 | Uriach & Cia Sa J | NEW DERIVATIVES OF (2-METHYL-3-PIRIDIL) CYANOMETILPIPERAZINES. |
FI941826A (en) | 1993-04-21 | 1994-10-22 | Takeda Chemical Industries Ltd | Methods and compositions for the prevention and / or therapeutic treatment of organ hypofunction |
US6030991A (en) | 1993-05-20 | 2000-02-29 | Texas Biotechnology Corp. | Benzenesulfonamides and the use thereof to modulate the activity of endothelin |
FR2707089B1 (en) * | 1993-06-30 | 1995-08-18 | Adir | New phosphonic acid derivatives, process for their preparation and pharmaceutical compositions containing them. |
US5389620A (en) * | 1993-08-18 | 1995-02-14 | Banyu Pharmaceutical Co., Ltd. | Endothelin antagonistic heteroaromatic ring-fused cyclopentene derivatives |
KR960703901A (en) | 1993-08-19 | 1996-08-31 | 로즈 암스트롱 | Substituted 2 (5H) furanone, 2 (5H) thiophenone and 2 (5H) pyrrolone derivatives, methods for their preparation and their use as endothelin antagonists (Substituted 2 (5H) Furanone, 2 (5H) Thiophenone and 2 (5H) Pyrrolone Derivatives, Their Preparation and Their Use as Endothelin antagonists) |
US5965732A (en) | 1993-08-30 | 1999-10-12 | Bristol-Myers Squibb Co. | Sulfonamide endothelin antagonists |
US6063911A (en) | 1993-12-01 | 2000-05-16 | Marine Polymer Technologies, Inc. | Methods and compositions for treatment of cell proliferative disorders |
IL111959A (en) * | 1993-12-17 | 2000-07-16 | Tanabe Seiyaku Co | N-(polysubstituted pyrimidin-4-yl) benzenesulfonamide derivatives their preparation and pharmaceutical compositions containing them |
US5546485A (en) * | 1993-12-20 | 1996-08-13 | At&T Corp. | Repeater for soliton transmission system using sliding-frequency guiding filter |
WO1995024385A1 (en) * | 1994-03-07 | 1995-09-14 | Vertex Pharmaceuticals Incorporated | Sulphonamide derivatives as aspartyl protease inhibitors |
GB9504854D0 (en) | 1994-03-31 | 1995-04-26 | Zeneca Ltd | Nitrogen derivatives |
GB9409618D0 (en) * | 1994-05-13 | 1994-07-06 | Zeneca Ltd | Pyridine derivatives |
US5675628A (en) | 1994-08-01 | 1997-10-07 | Nokia Telecommunications Oy | Method and apparatus for enabling roaming of subscriber among plural mobile radio systems, using mobile equipment accepting removable subscriber identity module |
US5612359A (en) * | 1994-08-26 | 1997-03-18 | Bristol-Myers Squibb Company | Substituted biphenyl isoxazole sulfonamides |
JP2930731B2 (en) | 1994-12-20 | 1999-08-03 | エフ・ホフマン−ラ ロシュ アーゲー | Aryl- and heteroaryl-sulfonamide derivatives, their preparation and their use as endothelin antagonists |
IL116916A (en) * | 1995-02-06 | 2000-09-28 | Bristol Myers Squibb Co | Substituted biphenyl sulfonamide derivatives and pharmaceutical compositions containing the same |
US5599811A (en) * | 1995-02-21 | 1997-02-04 | Warner-Lambert Company | Benzothiazine dioxides as endothelin antagonists |
DE19509950A1 (en) * | 1995-03-18 | 1996-09-19 | Merck Patent Gmbh | Endothelin receptor antagonists |
NZ306734A (en) * | 1995-04-04 | 2000-01-28 | Texas Biotechnology Corp | |
UA58494C2 (en) | 1995-06-07 | 2003-08-15 | Зенека Лімітед | N-heteroaryl-pyridinesulfonamide derivatives, pharmaceutical composition, process for preparing thereof and method for endothelin influence counteraction |
GB9512697D0 (en) * | 1995-06-22 | 1995-08-23 | Zeneca Ltd | Heterocyclic compounds |
US5922759A (en) | 1996-06-21 | 1999-07-13 | Warner-Lambert Company | Butenolide endothelin antagonists |
JPH09124620A (en) | 1995-10-11 | 1997-05-13 | Bristol Myers Squibb Co | Substituted biphenylsulfonamide endothelin antagonist |
BR9612061A (en) | 1995-12-20 | 1999-02-23 | Yamanouchi Pharma Co Ltd | Arylethersulfonamide derivatives and drug composition containing the same |
US5977117A (en) | 1996-01-05 | 1999-11-02 | Texas Biotechnology Corporation | Substituted phenyl compounds and derivatives thereof that modulate the activity of endothelin |
US5958905A (en) | 1996-03-26 | 1999-09-28 | Texas Biotechnology Corporation | Phosphoramidates, phosphinic amides and related compounds and the use thereof to modulate the activity of endothelin |
US6043241A (en) | 1996-04-10 | 2000-03-28 | Warner-Lambert Company | Ketoacid endothelin antagonists |
WO1997037986A1 (en) | 1996-04-10 | 1997-10-16 | Warner-Lambert Company | Endothelin antagonists with ether-linked groups |
US5804585A (en) | 1996-04-15 | 1998-09-08 | Texas Biotechnology Corporation | Thieno-pyridine sulfonamides derivatives thereof and related compounds that modulate the activity of endothelin |
TW536540B (en) | 1997-01-30 | 2003-06-11 | Bristol Myers Squibb Co | Endothelin antagonists: N-[[2'-[[(4,5-dimethyl-3-isoxazolyl)amino]sulfonyl]-4-(2-oxazolyl)[1,1'-biphenyl]-2-yl]methyl]-N,3,3-trimethylbutanamide and N-(4,5-dimethyl-3-isoxazolyl)-2'-[(3,3-dimethyl-2-oxo-1-pyrrolidinyl)methyl]-4'-(2-oxazolyl)[1,1'-biphe |
IL131318A (en) * | 1997-04-28 | 2004-08-31 | Encysive Pharmaceuticals Inc | Pharmaceutically acceptable salts of sulfonamides for treatment of endothelin-mediated disorders |
US5783705A (en) | 1997-04-28 | 1998-07-21 | Texas Biotechnology Corporation | Process of preparing alkali metal salys of hydrophobic sulfonamides |
DE60007697T2 (en) * | 1999-07-21 | 2004-12-09 | F. Hoffmann-La Roche Ag | triazole derivatives |
ATE286051T1 (en) * | 1999-12-31 | 2005-01-15 | Encysive Pharmaceuticals Inc | SULFONAMIDES AND THEIR DERIVATIVES THAT MODULATE THE ACTIVITY OF ENDOTHELIN |
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1996
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- 1997-09-26 SK SK365-99A patent/SK36599A3/en unknown
- 1997-09-26 EP EP03007240A patent/EP1342721A1/en not_active Withdrawn
- 1997-09-26 TR TR1999/00705T patent/TR199900705T2/en unknown
- 1997-09-26 JP JP51597998A patent/JP3743520B2/en not_active Expired - Lifetime
- 1997-09-26 PT PT97943629T patent/PT946552E/en unknown
- 1997-09-26 AU AU45059/97A patent/AU736269B2/en not_active Ceased
- 1997-09-26 ES ES97943629T patent/ES2224271T3/en not_active Expired - Lifetime
- 1997-09-26 IL IL12814597A patent/IL128145A0/en unknown
- 1997-09-26 EP EP97943629A patent/EP0946552B1/en not_active Expired - Lifetime
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- 1997-09-26 AP APAP/P/1999/001471A patent/AP9901471A0/en unknown
- 1997-09-26 WO PCT/US1997/017402 patent/WO1998013366A1/en not_active Application Discontinuation
- 1997-09-26 BR BR9711550-9A patent/BR9711550A/en not_active IP Right Cessation
- 1997-09-26 EA EA200300824A patent/EA200300824A1/en unknown
- 1997-09-26 CA CA002261760A patent/CA2261760C/en not_active Expired - Lifetime
- 1997-09-26 CN CNB031584780A patent/CN100558724C/en not_active Expired - Lifetime
- 1997-09-26 DE DE69729803T patent/DE69729803T2/en not_active Expired - Lifetime
- 1997-09-26 CN CNB971983437A patent/CN1215069C/en not_active Expired - Lifetime
- 1997-09-26 CZ CZ99854A patent/CZ85499A3/en unknown
- 1997-09-26 US US08/938,325 patent/US6420567B1/en not_active Expired - Fee Related
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- 1997-09-26 KR KR10-1999-7002629A patent/KR100372195B1/en not_active IP Right Cessation
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- 1999-03-22 US US09/274,280 patent/US6331637B1/en not_active Expired - Fee Related
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2001
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