CA2269310A1 - Local delivery of rapamycin for treatment of proliferative sequelae associated with ptca procedures, including delivery using a modified stent - Google Patents
Local delivery of rapamycin for treatment of proliferative sequelae associated with ptca procedures, including delivery using a modified stent Download PDFInfo
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- CA2269310A1 CA2269310A1 CA002269310A CA2269310A CA2269310A1 CA 2269310 A1 CA2269310 A1 CA 2269310A1 CA 002269310 A CA002269310 A CA 002269310A CA 2269310 A CA2269310 A CA 2269310A CA 2269310 A1 CA2269310 A1 CA 2269310A1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
- A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
- A61F2/91—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
- A61F2/915—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other
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- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
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- A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
- A61F2/91—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
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- A—HUMAN NECESSITIES
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/08—Materials for coatings
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- A—HUMAN NECESSITIES
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/16—Biologically active materials, e.g. therapeutic substances
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- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
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- A61F2/91—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
- A61F2/915—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other
- A61F2002/91533—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other characterised by the phase between adjacent bands
- A61F2002/91541—Adjacent bands are arranged out of phase
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- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
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- A61F2/91—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
- A61F2/915—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other
- A61F2002/9155—Adjacent bands being connected to each other
- A61F2002/91558—Adjacent bands being connected to each other connected peak to peak
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- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2250/0058—Additional features; Implant or prostheses properties not otherwise provided for
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- A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2250/0058—Additional features; Implant or prostheses properties not otherwise provided for
- A61F2250/0067—Means for introducing or releasing pharmaceutical products into the body
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
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- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
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Abstract
Delivery of rapamycin locally, particularly from an intravascular stem, directly from micropores in the stent body or mixed or bound to a polymer coating applied on stent, to inhibit neointimal tissue proliferation and thereby prevent restenosis. This invention also facilitates the performance of the stent in inhibiting restenosis.
Description
LOCAL DELIVERY OF RAPAMYCIN FOR TREATMENT OF PRQLIFERATIVE
SEQUELAE ASSOCIATED WITH PTCA PROCEDURES, INCLUDING DELIVERY USING A MODIFIED STENT
Field of the Invention:
io Delivery of rapamycin locally, particularly from an intravascular stent, directly from micropores in the stent body or mixed or bound to a polymer coating applied on stent, to inhibit neointimal tissue proliferation and thereby prevent restenosis. This invention also i5 facilitates the performance of the stem in inhibiting restenosis.
Background of the Invention:
Re-narrowing !restenosis) of an artherosclerotic 20 . coronary artery after percutaneous transluminal coronary angioplasty (PTCA) occurs in 10-50% of patients undergoing this procedure and subsequently requires either further angioplasty or coronary artery bypass graft. While the exact hormonal and cellular processes promoting restenosis z5 are still being determined, our present understanding is that the process of PTCA, besides opening the artherosclerotically obstructed artery, also injures resident coronary arterial smooth muscle cells (SMC). In response to this injury, adhering platelets, infiltrating so macrophages, leukocytes, or the smooth muscle cells (SMC) themselves release cell derived growth factors with subsequent proliferation and migration of medial SMC
through the internal elastic lamina to the area of the vessel intima. Farther proliferation and hyperplasia of
SEQUELAE ASSOCIATED WITH PTCA PROCEDURES, INCLUDING DELIVERY USING A MODIFIED STENT
Field of the Invention:
io Delivery of rapamycin locally, particularly from an intravascular stent, directly from micropores in the stent body or mixed or bound to a polymer coating applied on stent, to inhibit neointimal tissue proliferation and thereby prevent restenosis. This invention also i5 facilitates the performance of the stem in inhibiting restenosis.
Background of the Invention:
Re-narrowing !restenosis) of an artherosclerotic 20 . coronary artery after percutaneous transluminal coronary angioplasty (PTCA) occurs in 10-50% of patients undergoing this procedure and subsequently requires either further angioplasty or coronary artery bypass graft. While the exact hormonal and cellular processes promoting restenosis z5 are still being determined, our present understanding is that the process of PTCA, besides opening the artherosclerotically obstructed artery, also injures resident coronary arterial smooth muscle cells (SMC). In response to this injury, adhering platelets, infiltrating so macrophages, leukocytes, or the smooth muscle cells (SMC) themselves release cell derived growth factors with subsequent proliferation and migration of medial SMC
through the internal elastic lamina to the area of the vessel intima. Farther proliferation and hyperplasia of
- 2 -s intimal SMC and, most significantly, production of large amounts of extracellular matrix over a period of 3-6 months results in the filling in and narrowing of the vascular space sufficient to significantly obstruct coronary blood flow.
io Several recent experimental approaches to preventing SMC proliferation have shown promise althrough the mechanisms for most agents employed are still unclear.
Heparin is the best known and characterized agent causing is inhibition of SMC proliferation both in vitro and in animal mpdels of balloon angioplasty-mediated injury. The mechanism of SMC inhibition with heparin is still not known but may be due to any or all of the following: 1) reduced expression of the growth regulatory protooncogenes 2o c-fos and c-myc, 2) reduced cellular production of tissue plasminogen activator; are 3) binding and dequestration of growth regulatory factors such as fibrovalent growth factor (FGF) .
25 Other agents which have demonstrated the ability to reduce myointimal thickening in animal models of balloon vascular injury are angiopeptin (a somatostatin analog), calcium channel blockers, angiotensin converting enzyme inhibitors (captopril, cilazapril), cyclosporin A, 3o trapidil (an antianginal, antiplatelet agent), terbinafine (antifungal), colchicine and taxol (antitubulin antiproliferatives), and c-myc and c-lrcyb antinsense oligonucleotides.
io Several recent experimental approaches to preventing SMC proliferation have shown promise althrough the mechanisms for most agents employed are still unclear.
Heparin is the best known and characterized agent causing is inhibition of SMC proliferation both in vitro and in animal mpdels of balloon angioplasty-mediated injury. The mechanism of SMC inhibition with heparin is still not known but may be due to any or all of the following: 1) reduced expression of the growth regulatory protooncogenes 2o c-fos and c-myc, 2) reduced cellular production of tissue plasminogen activator; are 3) binding and dequestration of growth regulatory factors such as fibrovalent growth factor (FGF) .
25 Other agents which have demonstrated the ability to reduce myointimal thickening in animal models of balloon vascular injury are angiopeptin (a somatostatin analog), calcium channel blockers, angiotensin converting enzyme inhibitors (captopril, cilazapril), cyclosporin A, 3o trapidil (an antianginal, antiplatelet agent), terbinafine (antifungal), colchicine and taxol (antitubulin antiproliferatives), and c-myc and c-lrcyb antinsense oligonucleotides.
- 3 -Additionally, a goat antibody to the SMC mitogen platelet derived growth factor (PDGF) has been shown to be effective in reducing myointimal thickening in a rat model of balloon angioplasty injury, thereby implicating PDGF
directly in the etiology of restenosis. Thus, while no to therapy has as yet proven successful clinically in preventing restenosis after angioplasty, the in vivo experimental success of several agents known to inhibit SMC growth suggests that these agents as a class have the capacity to prevent clinical restenosis and deserve i5 careful evaluation in humans.
Coronary heart disease is the major cause of death in men over the age of 40 and in women over the age of fifty 20 . in the western world. Most coronary artery-related deaths are due to atherosclerosis. Atherosclerotic lesions which limit or obstruct coronary blood flow are the major cause of ischemic heart disease related mortality and result in 500,000-600,000 deaths in the United States annually. To 25 arrest the disease process and prevent the more advanced disease states in which the cardiac muscle itself is compromised, direct intervention has been employed via percutaneous transiuminal coronary angioplasty (PTCA) or coronary artery bypass graft (CABG).
PTCA is a procedure in which a small balloon-tipped catheter is passed down a narrowed coronary artery and then expanded to re-open the artery. It is currently performed in approximately 250,000-300,000 patients each
directly in the etiology of restenosis. Thus, while no to therapy has as yet proven successful clinically in preventing restenosis after angioplasty, the in vivo experimental success of several agents known to inhibit SMC growth suggests that these agents as a class have the capacity to prevent clinical restenosis and deserve i5 careful evaluation in humans.
Coronary heart disease is the major cause of death in men over the age of 40 and in women over the age of fifty 20 . in the western world. Most coronary artery-related deaths are due to atherosclerosis. Atherosclerotic lesions which limit or obstruct coronary blood flow are the major cause of ischemic heart disease related mortality and result in 500,000-600,000 deaths in the United States annually. To 25 arrest the disease process and prevent the more advanced disease states in which the cardiac muscle itself is compromised, direct intervention has been employed via percutaneous transiuminal coronary angioplasty (PTCA) or coronary artery bypass graft (CABG).
PTCA is a procedure in which a small balloon-tipped catheter is passed down a narrowed coronary artery and then expanded to re-open the artery. It is currently performed in approximately 250,000-300,000 patients each
- 4 -s year. The major advantage of this therapy is that patients in which the procedure is successful need not undergo the more invasive surgical procedure of coronary artery bypass graft. A major difficulty with PTCA is the problem of post-angioplasty closure of the vessel, both io imanediately after PTCA (acute reocclusion) and in the long term (restenosis).
The mechanism of acute reocclusion appears to involve several factors and may result from vascular recoil with 15 resultant closure of the artery and/or deposition of blood platelets along the damaged length of the newly opened blood vessel 'ollowed by formation of a fibrin/red blood cell thrombus. Recently, intravascular stents have been examined as a means of preventing acute reclosure after 20 PTCA.
Restenosis (chronic reclosure) after angioplasty is a more gradual process than acute reocclusion: 30~ of patients with subtotal lesions and 50~ of patients with 25 chronic total lesions will go on to restenosis after angioplasty. While the exact mechanism for restenosis is still under active investigation, the general aspects of the restenosis process have been identified.~
3o In the normal arterial will, smooth muscle cells (SMC) proliferate at a low rate (<O.lo/day: ref). SMC in vessel wall exists in a 'contractile' phenotype characterized by 80-90~ of the cell cytoplasmic volume occupied with the contractile apparatus. Endoplasmic
The mechanism of acute reocclusion appears to involve several factors and may result from vascular recoil with 15 resultant closure of the artery and/or deposition of blood platelets along the damaged length of the newly opened blood vessel 'ollowed by formation of a fibrin/red blood cell thrombus. Recently, intravascular stents have been examined as a means of preventing acute reclosure after 20 PTCA.
Restenosis (chronic reclosure) after angioplasty is a more gradual process than acute reocclusion: 30~ of patients with subtotal lesions and 50~ of patients with 25 chronic total lesions will go on to restenosis after angioplasty. While the exact mechanism for restenosis is still under active investigation, the general aspects of the restenosis process have been identified.~
3o In the normal arterial will, smooth muscle cells (SMC) proliferate at a low rate (<O.lo/day: ref). SMC in vessel wall exists in a 'contractile' phenotype characterized by 80-90~ of the cell cytoplasmic volume occupied with the contractile apparatus. Endoplasmic
- 5 -s reticulum, golgi bodies, and free ribosomes are few and located in the perinuclear region. Extracellular matrix surrounds SMC and is rich in heparin-like glycosylaminoglycans which are believed to be responsible for maintaining SMC in the contractile phenotypic state.
Upon pressure expansion of an intracoronary balloon catheter during angioplasty, smooth muscle cells within the arterial wall become injured. Cell derived growth factors such as platelet derived growth factor (PDGF), basic fibroblast growth factor (bFGF), epidermal growth factor (EGF), etc. released from platelets (i.e., PDGF) adhering to the damaged arterial luminal surface, invading macrophages and/or leukocytes, or directly from SMC (i.e., BFGF) provoke a proliferation and migratory response in 2o medial SMC. These cells undergo a phenotypic change from the contractile phenotyope to a 'synthetic' phenotype characterized by only few contractile filament bundles but extensive rough endoplasmic reticulum, golgi and free ribosomes. Proliferation/migration usually begins within 1-2 days post-injury and peaks at 2 days in the media, rapidly declining thereafter (Campbell et al., In:
Vascular Smooth Muscle Cells in Culture, Campbell, J.H.
and Campbell, G.R., Eds, CRC Press, Boca Ration, 1987, pp.
39-55); Clowes, A.W. and Schwartz,. S.M., Circ. Res.
56:139-145, 1985).
Finally, daughter synthetic cells migrate to the intimal layer of arterial smooth muscle and continue to proliferate. Proliferation and migration continues until
Upon pressure expansion of an intracoronary balloon catheter during angioplasty, smooth muscle cells within the arterial wall become injured. Cell derived growth factors such as platelet derived growth factor (PDGF), basic fibroblast growth factor (bFGF), epidermal growth factor (EGF), etc. released from platelets (i.e., PDGF) adhering to the damaged arterial luminal surface, invading macrophages and/or leukocytes, or directly from SMC (i.e., BFGF) provoke a proliferation and migratory response in 2o medial SMC. These cells undergo a phenotypic change from the contractile phenotyope to a 'synthetic' phenotype characterized by only few contractile filament bundles but extensive rough endoplasmic reticulum, golgi and free ribosomes. Proliferation/migration usually begins within 1-2 days post-injury and peaks at 2 days in the media, rapidly declining thereafter (Campbell et al., In:
Vascular Smooth Muscle Cells in Culture, Campbell, J.H.
and Campbell, G.R., Eds, CRC Press, Boca Ration, 1987, pp.
39-55); Clowes, A.W. and Schwartz,. S.M., Circ. Res.
56:139-145, 1985).
Finally, daughter synthetic cells migrate to the intimal layer of arterial smooth muscle and continue to proliferate. Proliferation and migration continues until
- 6 -the damaged luminal endothelial layer regenerates at which time proliferation ceases within the intima, usually within 7-14 days postinjury. The remaining increase in intimal thickening which occurs over the next 3-6 months is due to an increase in extracellular matrix rather than io cell number. Thus, SMC migration and proliferation is an acute response to vessel injury while intimal hyperplasia is a more chronic response. (Liu et al., Circulation, 79:1374-1387, 1989).
Patients with symptomatic reocclusion require either repeat PTCA or CABG. Because 30-50~ of patients undergoing PTCA will experience restenosis, restenosis has clearly limited the success of PTCA as a therapeutic approach to coronary artery disease. Because SMC
2o proliferation and migration are intimately involved with the pathophysiological response to arterial injury, prevention of SMC proliferation and migration represents a target for pharmacological intervention in the prevention of restenosis.
Sut~anary of the Invention Novel Features and Applications to Stent Technology 3o Currently, attempts to improve the clinical performance of stents have involved some variation of either applying a coating to the metal, attaching a covering or membrane, or embedding material on the surface via ion bombardment. A stent designed to include reservoirs is a new approach which offers several important advantages over existing technologies.
Local Drug Delivery from a Stent to Inhibit Restenosis 1o In this application, it is desired to deliver a therapeutic agent to the site of arterial injury. The conventional approach has been to incorporate the therapeutic agent into a polymer material which is then coated on the stent. The ideal coating material must be able to adhere strongly to the metal stent both before and after expansion, be capable of retaining the drug at a sufficient load level to obtain the required dose, be able to release the drug in a controlled way over a period of several weeks, and be as thin as possible so as to 2o minimize the increase in profile. In addition, the coating material should not contribute to any adverse response by the body (i.e., should be non-thrombogenic, non-inflammatory, etc.). To date, the ideal coating material has not been developed for this application.
An alternative would be to design the stent to contain reservoirs which could be loaded with the drug. A
coating or membrane of biocompatable material could be applied over the reservoirs which would control the 3o diffusion of the drug from the reservoirs to the artery wall.
One advantage of this system is that the properties of the coating can be optimized for achieving superior _ g _ s biocompatibility and adhesion properties, without the addition requirement of being able to load and release the drug. The size, shape, position, and number of reservoirs can be used to control the amount of drug, and therefore the dose delivered.
Description of the Drawings:
The invention will be better understood in connection with the following figures in which Figures 1 and lA are i5 top views and section views of a stent containing reservoirs as described in the present invention:
Figures 2a and 2b are similar views of an alternate embodiment of the stent with open ends;
Figures 3a and 3b are further alternate figures of a device containing a grooved reservoir; and Figure 4 is a layout view of a device containing a reservoir as in Figure 3.
Detailed Description of the Invention Pharmacological attempts to prevent 'restenosis by pharmacologic means have thus far been unsuccessful and 3o all involve systemic administration of the trial agents.
Neither aspirin-dipyridamole, ticlopidine, acute heparin administration, chronic warfarin (6 months) nor methylprednisolone have been effective in preventing restenosis although platelet inhibitors have been _ g _ effective in preventing acute reocclusion after angioplasty. The calcium antagonists have also been unsuccessful in preventing restenosis, although they are still under study. Other agents currently under study include thromboxane inhibitors, prostacyclin mimetics, to platelet membrane receptor blockers, thrombin inhibitors and angiotensin converting enzyme inhibitors. These agents must be given systemically, however, and attainment of a therapeutically effective dose may not be possible;
antiproliferative (or anti-restenosis) concentrations may exceed the known toxic concentrations of these agents so that levels sufficient to produce smooth muscle inhibition may not be reached (Lang et al., 42 Ann. Rev. Med., 127-132 (1991); Popma et al., 84 Circulation, 1426-1436 ( 1991 ) ) .
Additional clinical trials in which the effectiveness for preventing restenosis of dietary fish oil supplements, thromboxane receptor antagonists, cholesterol lowering agents, and serotonin antagonists has been examined have shown either conflicting or negative results so that no pharmacological agents are as yet clinically available to prevent post-angioplasty restenosis (Franklin, S.M. and Faxon, D.P., 4 Coronary Artery Disease, 232-242 (1993);
Serruys, P.W. et al., 88 Circulation,(part 1) 1588-1601, ( 1993 ) .
Conversely, stents have proven useful in preventing reducing the proliferation of restenosis. Stents, such as the stent 10 seen in layout in Figure 4, balloon-expandable slotted metal tubes (usually but not limited to stainless steel), which when expanded within the lumen of an angioplastied coronary artery, provide structural support to the arterial wall. This support is helpful in maintaining an open path for blood flow. In two randomized clinical trials, stents were shown to increase angiographic success after PTCA, increase the stenosed blood vessel lumen and to reduce the lesion recurrence at 6 months (Serruys et al., 331 New Eng Jour. Med, 495, (1994); Fischman et al., 331 New Eng Jour. Med, 496-501 is (1994). Additionally, in a preliminary trial, heparin coated stents appear to possess the same benefit of reduction in stenosis diameter at follow-up as was observed with non-heparin coated stents. Additionally, heparin coating appears to have the added benefit of 2o producing a reduction in sub-acute thrombosis after stent implantation (Serruys et al., 93 Circulation, 412-422, (1996). Thus, 1) sustained mechanical expansion of a stenosed coronary artery has been shown to provide some measure of restenosis prevention, and 2) coating of stents 2s with heparin has demonstrated both the feasibility and the clinical usefulness of delivering drugs to local, injured tissue off the surface of the stent.
Numerous agents are being actively studied as so antiproliferative agents for use in restenosis and have shown some activity in experimental animal models. These include: heparin and heparin fragments (Clowes and Karnovsky, 265 Nature, 25-626, (1977) ; Guyton, J.R. et al.
46 Circ. Res., 625-634, (1980); Clowes, A.W. and Clowes, M.M., 52 Lab. Invest., 611-616, (1985); Cloves, A.W. and Cloves, M.M., 58 Circ. Res., 839-845 (1986); Majesky et al., 61 Circ Res., 296-300, (1987); Snow et al., 137 Am.
J. Pathol., 313-330 (1990); Okada, T. et al., 25 Neurosurgery, 92-898, (1989) colchicine (furrier, J.W. et io al., 80 Circulation, 11-66, (1989), taxol (ref), agiotensin converting enzyme (ACE) inhibitors (Powell, J.S. et al., 245 Science, 186-188 (1989), angiopeptin (Lundergan, C.F. et al., 17 Am. J. Cardiol. (Suppl. B);
132B-136B (1991), Cyclosporin A (Jonasson, L. et. al., 85 Proc. Nati, Acad. Sci., 2303 (1988), goat-anti-rabbit PDGF
antibody (Ferns, G.A.A., et al., 253 Science, 1129-1132 (1991), terbinafine (Nemecek, G.M. et al., 248 J.
Pharmacol. Exp. Thera., 1167-11747 (1989), trapidil (Liu, M.W. et al., 81 Circulation, 1089-1093 (1990), interferon-2o gamma (Hansson, G.K. and F-iolm, 84 J. Circulation, 1266-1272 (1991), steroids (Colburn, M.D. et al., 15 J. Vasc.
Surg., 510-518 (1992), see also Berk, B.C. et al., 17 J.
Am. Coll. Cardiol., 111B-1 17B (1991), ionizing radiation (ref), fusion toxins (ref) antisense oligonucleotides (ref). gene vectors (ref), and rapamycin (see below).
Of particular interest in rapamycin. Rapamycin is a macrolide antibiotic which blocks IL-2- mediated T-cell proliferation and possesses antiinflammatory activity.
3o While the precise mechanism of rapamycin is still under active investigation, rapamycin has been shown to prevent the G1 to S phase progression of T-cells through the cell cycle by inhibiting specific cell cyclins and cyclin-dependent protein kinases (Siekierka, Immunol. Res. 13:
110-116, 1994). The antiproliferative action of rapamycin is not limited to T-cells; Marx et al. (Circ Res 76:412-417, 1995) have demonstrated that rapamycin prevents proliferation of both rat and human SMC in vitro while Poon et al. have shown the rat, porcine, and human SMC
io migratin can also be inhibited by rapamycin (J Clin Invest 98: 2277-2283, 1996). Thus, rapamycin is capable of inhibiting both the inflammatory response known to occur after arterial injury and stent implantation, as well as the SMC hyperproliferative response. In fact, the i5 combined effects of rapamycin have been demonstrated to result in a diminished SMC hyperproliferative response in a rat femoral artery graft model and in both rat and porcine arterial balloon injury models (Gregory et al., Transplantation 55:1409-1418, 1993; Gallo et al., in 2o press, (1997)). These observations clearly support the potential use of rapamycin in the clinical setting of post-angioplasty restenosis.
Although the ideal agent for restenosis has not yet 25 been identified, some desired properties are clear:
inhibition of local thrombosis without the risk systemic bleeding complications and continuous and prevention of the dequale of arterial injury, including local inflammation and sustained prevention smooth muscle 3o proliferation at the site of angioplasty without serious systemic complications. Inasmuch as stents prevent at least a portion of the restenosis process, an agent which prevents inflammation and the proliferation of SMC
combined with a stent may provide the most efficacious treatment for post-angioplasty restenosis.
Experiments to Agents: Rapamycin (sirolimus) structural analogs (macrocyclic lactones) and inhibitors of cell-cycle progression.
Delivery Methods:
These can vary:
- Local delivery of such agents (rapamycin) from the struts of a stent, from a stent graft, grafts, stent 2o cover or sheath.
- Involving comixture with polymers (both degradable and nondegrading) to hold the drug to the stent or graft.
- or entrapping the drug into the metal of the stent or graft body which has been modified to contain micropores or channels, as will be explained further herein.
- or including covalent binding of the drug to the stent via solution chemistry techniques (such as via the Carmeda process) or dry chemistry techniques (e. g. vapour deposition methods such as rf-plasma polymerization) and combinations thereof.
- Catheter delivery intravascularly from a tandem balloon or a porous balloon for intramural uptake to - Extravascular delivery by the pericardial route - Extravascular delivery by the advential application of sustained release formulations.
Uses: for inhibition of cell proliferation to prevent neointimal proliferation and restenosis.
prevention of tumor expansion from stents prevent ingrowth of tissue into catheters and 2o shunts inducing their failure.
1. Experimental Stent Delivery Method - Delivery from Polymer Matrix:
Solution of Rapamycin, prepared in a solvent miscible with polymer carrier solution, is mixed with solution of polymer at final concentration range 0.001 weight o to 30 weight o of drug. Polymers are biocompatible (i.e., not elicit any negative tissue reaction or promote mural 3o thrombus formation) and degradable, such as lactone-based polyesters or copolyesters, e.g., polylactide, polycaprolacton-glycolide,polyorthoesters, polyanhydrides;
poly-aminoacids; polysaccharides; polyphosphazenes;
poly(ether-ester) copolymers, e.g., PEO-PLLA, or blends thereof. Nonabsorbable biocompatible polymers are also suitable candidates. Polymers such as polydimethyl-siolxane; polyethylene-vingylacetate); acrylate based polymers or copolymers, e.g., poly(hydroxyethyl methylmethacrylate, polyvinyl pyrrolidinone; fluorinated io polymers such as polytetrafluoroethylene; cellulose esters.
Polymer/drug mixture is applied to the surfaces of the stent by either dip-coating, or spray coating, or i5 brush coating or dip/spin coating or combinations thereof, and the. solvent allowed to evaporate to leave a film with entrapped rapamycin.
2. Ex erimental Stent Delivery Method - Delivery from 2o Microporous Depots in Stent Through a Polymer Membrane Coating:
Stent, whose body has been modified to contain micropores or channels is dipped into a solution of 2s Rapamycin, range 0.001 wt~ to saturated, in organic solvent such as acetone or methylene chloride, for sufficient time to allow solution to permeate into the pores. (The dipping solution can also be' compressed to improve the loading efficiency.) After solvent has been 3o allowed to evaporate, the stent is dipped briefly in fresh solvent to remove excess surface bound drug. A solution of polymer, chosen from any identified in the first experimental method, is applied to the stem as detailed s above. This outerlayer of polymer will act as diffusion-controller for release of drug.
3. Experimental Stent Delivery- Method - Delivery via lysis of a Covalent Drug Tether io Rapamycin is modified to contain a hydrolytically or enzymatically labile covalent bond for attaching to the surface of the stem which itself has been chemically derivatized to allow covalent immobilization. Covalent 15 bonds such as ester, amides or anhydrides may be suitable for this.
4. Experimental Method - Pericardial Delivery 20 _ A: Polymeric Sheet Rapamycin is combined at concentration range previously highlighted, with a degradable polymer such as poly(caprolactone-gylcolide) or non-degradable polymer, e.g., polydimethylsiloxane, and mixture cast as a thin sheet, thickness range l0u to z5 1000u. The resulting sheet can be wrapped perivascularly on the target vessel. Preference would be for the absorbable polymer.
B: Conformal Coating: Rapamycin is combined with a 3o polymer that has a melting temperature just above 37°C, range 40°-45°C. Mixture is applied in a molten state to the external side of the target vessel. Upon cooling to body temperature the mixture solidifies conformally to the vessel wall. Both non-degradable and absorbable biocompatible polymers are suitable.
As seen in the figures it is also possible to modify currently manufactured stents in order to adequately io provide the drug dosages such as rapamycin. As seen in Figures la, 2a and 3a, any stent strut 10, 20, 30 can be modified to have a certain reservoir or channel 11, 21, 31. Each of these reservoirs can be open or closed as desired. These reservoirs can hold the drug to be delivered. Figure 4 shows a stent 40 with a reservoir 45 created at the apex of a flexible strut. Of course, this reservoir 45 is intended to be useful to deliver rapamycin or any other drug at a specific point of flexibility of the stem . Accordingly, this concept can be useful for "second generation" type stents.
In any of the foregoing devices, however, it is useful to have the drug dosage applied with enough specificity and enough concentration to provide an effective dosage in the lesion area. In this regard, the reservoir size in the stent struts must be kept at a size of about 0.0005" to about 0.003". Then, it should be possible to adequately apply the drug dosage at the desired location and in the desired amount.
These and other concepts will are disclosed herein.
It would be apparent to the reader that modifications are possible to the stent or the drug dosage applied. In any event, however, the any obvious modifications should be s perceived to fall within the scope of the invention which is to be realized from the attached claims and their equivalents.
Patients with symptomatic reocclusion require either repeat PTCA or CABG. Because 30-50~ of patients undergoing PTCA will experience restenosis, restenosis has clearly limited the success of PTCA as a therapeutic approach to coronary artery disease. Because SMC
2o proliferation and migration are intimately involved with the pathophysiological response to arterial injury, prevention of SMC proliferation and migration represents a target for pharmacological intervention in the prevention of restenosis.
Sut~anary of the Invention Novel Features and Applications to Stent Technology 3o Currently, attempts to improve the clinical performance of stents have involved some variation of either applying a coating to the metal, attaching a covering or membrane, or embedding material on the surface via ion bombardment. A stent designed to include reservoirs is a new approach which offers several important advantages over existing technologies.
Local Drug Delivery from a Stent to Inhibit Restenosis 1o In this application, it is desired to deliver a therapeutic agent to the site of arterial injury. The conventional approach has been to incorporate the therapeutic agent into a polymer material which is then coated on the stent. The ideal coating material must be able to adhere strongly to the metal stent both before and after expansion, be capable of retaining the drug at a sufficient load level to obtain the required dose, be able to release the drug in a controlled way over a period of several weeks, and be as thin as possible so as to 2o minimize the increase in profile. In addition, the coating material should not contribute to any adverse response by the body (i.e., should be non-thrombogenic, non-inflammatory, etc.). To date, the ideal coating material has not been developed for this application.
An alternative would be to design the stent to contain reservoirs which could be loaded with the drug. A
coating or membrane of biocompatable material could be applied over the reservoirs which would control the 3o diffusion of the drug from the reservoirs to the artery wall.
One advantage of this system is that the properties of the coating can be optimized for achieving superior _ g _ s biocompatibility and adhesion properties, without the addition requirement of being able to load and release the drug. The size, shape, position, and number of reservoirs can be used to control the amount of drug, and therefore the dose delivered.
Description of the Drawings:
The invention will be better understood in connection with the following figures in which Figures 1 and lA are i5 top views and section views of a stent containing reservoirs as described in the present invention:
Figures 2a and 2b are similar views of an alternate embodiment of the stent with open ends;
Figures 3a and 3b are further alternate figures of a device containing a grooved reservoir; and Figure 4 is a layout view of a device containing a reservoir as in Figure 3.
Detailed Description of the Invention Pharmacological attempts to prevent 'restenosis by pharmacologic means have thus far been unsuccessful and 3o all involve systemic administration of the trial agents.
Neither aspirin-dipyridamole, ticlopidine, acute heparin administration, chronic warfarin (6 months) nor methylprednisolone have been effective in preventing restenosis although platelet inhibitors have been _ g _ effective in preventing acute reocclusion after angioplasty. The calcium antagonists have also been unsuccessful in preventing restenosis, although they are still under study. Other agents currently under study include thromboxane inhibitors, prostacyclin mimetics, to platelet membrane receptor blockers, thrombin inhibitors and angiotensin converting enzyme inhibitors. These agents must be given systemically, however, and attainment of a therapeutically effective dose may not be possible;
antiproliferative (or anti-restenosis) concentrations may exceed the known toxic concentrations of these agents so that levels sufficient to produce smooth muscle inhibition may not be reached (Lang et al., 42 Ann. Rev. Med., 127-132 (1991); Popma et al., 84 Circulation, 1426-1436 ( 1991 ) ) .
Additional clinical trials in which the effectiveness for preventing restenosis of dietary fish oil supplements, thromboxane receptor antagonists, cholesterol lowering agents, and serotonin antagonists has been examined have shown either conflicting or negative results so that no pharmacological agents are as yet clinically available to prevent post-angioplasty restenosis (Franklin, S.M. and Faxon, D.P., 4 Coronary Artery Disease, 232-242 (1993);
Serruys, P.W. et al., 88 Circulation,(part 1) 1588-1601, ( 1993 ) .
Conversely, stents have proven useful in preventing reducing the proliferation of restenosis. Stents, such as the stent 10 seen in layout in Figure 4, balloon-expandable slotted metal tubes (usually but not limited to stainless steel), which when expanded within the lumen of an angioplastied coronary artery, provide structural support to the arterial wall. This support is helpful in maintaining an open path for blood flow. In two randomized clinical trials, stents were shown to increase angiographic success after PTCA, increase the stenosed blood vessel lumen and to reduce the lesion recurrence at 6 months (Serruys et al., 331 New Eng Jour. Med, 495, (1994); Fischman et al., 331 New Eng Jour. Med, 496-501 is (1994). Additionally, in a preliminary trial, heparin coated stents appear to possess the same benefit of reduction in stenosis diameter at follow-up as was observed with non-heparin coated stents. Additionally, heparin coating appears to have the added benefit of 2o producing a reduction in sub-acute thrombosis after stent implantation (Serruys et al., 93 Circulation, 412-422, (1996). Thus, 1) sustained mechanical expansion of a stenosed coronary artery has been shown to provide some measure of restenosis prevention, and 2) coating of stents 2s with heparin has demonstrated both the feasibility and the clinical usefulness of delivering drugs to local, injured tissue off the surface of the stent.
Numerous agents are being actively studied as so antiproliferative agents for use in restenosis and have shown some activity in experimental animal models. These include: heparin and heparin fragments (Clowes and Karnovsky, 265 Nature, 25-626, (1977) ; Guyton, J.R. et al.
46 Circ. Res., 625-634, (1980); Clowes, A.W. and Clowes, M.M., 52 Lab. Invest., 611-616, (1985); Cloves, A.W. and Cloves, M.M., 58 Circ. Res., 839-845 (1986); Majesky et al., 61 Circ Res., 296-300, (1987); Snow et al., 137 Am.
J. Pathol., 313-330 (1990); Okada, T. et al., 25 Neurosurgery, 92-898, (1989) colchicine (furrier, J.W. et io al., 80 Circulation, 11-66, (1989), taxol (ref), agiotensin converting enzyme (ACE) inhibitors (Powell, J.S. et al., 245 Science, 186-188 (1989), angiopeptin (Lundergan, C.F. et al., 17 Am. J. Cardiol. (Suppl. B);
132B-136B (1991), Cyclosporin A (Jonasson, L. et. al., 85 Proc. Nati, Acad. Sci., 2303 (1988), goat-anti-rabbit PDGF
antibody (Ferns, G.A.A., et al., 253 Science, 1129-1132 (1991), terbinafine (Nemecek, G.M. et al., 248 J.
Pharmacol. Exp. Thera., 1167-11747 (1989), trapidil (Liu, M.W. et al., 81 Circulation, 1089-1093 (1990), interferon-2o gamma (Hansson, G.K. and F-iolm, 84 J. Circulation, 1266-1272 (1991), steroids (Colburn, M.D. et al., 15 J. Vasc.
Surg., 510-518 (1992), see also Berk, B.C. et al., 17 J.
Am. Coll. Cardiol., 111B-1 17B (1991), ionizing radiation (ref), fusion toxins (ref) antisense oligonucleotides (ref). gene vectors (ref), and rapamycin (see below).
Of particular interest in rapamycin. Rapamycin is a macrolide antibiotic which blocks IL-2- mediated T-cell proliferation and possesses antiinflammatory activity.
3o While the precise mechanism of rapamycin is still under active investigation, rapamycin has been shown to prevent the G1 to S phase progression of T-cells through the cell cycle by inhibiting specific cell cyclins and cyclin-dependent protein kinases (Siekierka, Immunol. Res. 13:
110-116, 1994). The antiproliferative action of rapamycin is not limited to T-cells; Marx et al. (Circ Res 76:412-417, 1995) have demonstrated that rapamycin prevents proliferation of both rat and human SMC in vitro while Poon et al. have shown the rat, porcine, and human SMC
io migratin can also be inhibited by rapamycin (J Clin Invest 98: 2277-2283, 1996). Thus, rapamycin is capable of inhibiting both the inflammatory response known to occur after arterial injury and stent implantation, as well as the SMC hyperproliferative response. In fact, the i5 combined effects of rapamycin have been demonstrated to result in a diminished SMC hyperproliferative response in a rat femoral artery graft model and in both rat and porcine arterial balloon injury models (Gregory et al., Transplantation 55:1409-1418, 1993; Gallo et al., in 2o press, (1997)). These observations clearly support the potential use of rapamycin in the clinical setting of post-angioplasty restenosis.
Although the ideal agent for restenosis has not yet 25 been identified, some desired properties are clear:
inhibition of local thrombosis without the risk systemic bleeding complications and continuous and prevention of the dequale of arterial injury, including local inflammation and sustained prevention smooth muscle 3o proliferation at the site of angioplasty without serious systemic complications. Inasmuch as stents prevent at least a portion of the restenosis process, an agent which prevents inflammation and the proliferation of SMC
combined with a stent may provide the most efficacious treatment for post-angioplasty restenosis.
Experiments to Agents: Rapamycin (sirolimus) structural analogs (macrocyclic lactones) and inhibitors of cell-cycle progression.
Delivery Methods:
These can vary:
- Local delivery of such agents (rapamycin) from the struts of a stent, from a stent graft, grafts, stent 2o cover or sheath.
- Involving comixture with polymers (both degradable and nondegrading) to hold the drug to the stent or graft.
- or entrapping the drug into the metal of the stent or graft body which has been modified to contain micropores or channels, as will be explained further herein.
- or including covalent binding of the drug to the stent via solution chemistry techniques (such as via the Carmeda process) or dry chemistry techniques (e. g. vapour deposition methods such as rf-plasma polymerization) and combinations thereof.
- Catheter delivery intravascularly from a tandem balloon or a porous balloon for intramural uptake to - Extravascular delivery by the pericardial route - Extravascular delivery by the advential application of sustained release formulations.
Uses: for inhibition of cell proliferation to prevent neointimal proliferation and restenosis.
prevention of tumor expansion from stents prevent ingrowth of tissue into catheters and 2o shunts inducing their failure.
1. Experimental Stent Delivery Method - Delivery from Polymer Matrix:
Solution of Rapamycin, prepared in a solvent miscible with polymer carrier solution, is mixed with solution of polymer at final concentration range 0.001 weight o to 30 weight o of drug. Polymers are biocompatible (i.e., not elicit any negative tissue reaction or promote mural 3o thrombus formation) and degradable, such as lactone-based polyesters or copolyesters, e.g., polylactide, polycaprolacton-glycolide,polyorthoesters, polyanhydrides;
poly-aminoacids; polysaccharides; polyphosphazenes;
poly(ether-ester) copolymers, e.g., PEO-PLLA, or blends thereof. Nonabsorbable biocompatible polymers are also suitable candidates. Polymers such as polydimethyl-siolxane; polyethylene-vingylacetate); acrylate based polymers or copolymers, e.g., poly(hydroxyethyl methylmethacrylate, polyvinyl pyrrolidinone; fluorinated io polymers such as polytetrafluoroethylene; cellulose esters.
Polymer/drug mixture is applied to the surfaces of the stent by either dip-coating, or spray coating, or i5 brush coating or dip/spin coating or combinations thereof, and the. solvent allowed to evaporate to leave a film with entrapped rapamycin.
2. Ex erimental Stent Delivery Method - Delivery from 2o Microporous Depots in Stent Through a Polymer Membrane Coating:
Stent, whose body has been modified to contain micropores or channels is dipped into a solution of 2s Rapamycin, range 0.001 wt~ to saturated, in organic solvent such as acetone or methylene chloride, for sufficient time to allow solution to permeate into the pores. (The dipping solution can also be' compressed to improve the loading efficiency.) After solvent has been 3o allowed to evaporate, the stent is dipped briefly in fresh solvent to remove excess surface bound drug. A solution of polymer, chosen from any identified in the first experimental method, is applied to the stem as detailed s above. This outerlayer of polymer will act as diffusion-controller for release of drug.
3. Experimental Stent Delivery- Method - Delivery via lysis of a Covalent Drug Tether io Rapamycin is modified to contain a hydrolytically or enzymatically labile covalent bond for attaching to the surface of the stem which itself has been chemically derivatized to allow covalent immobilization. Covalent 15 bonds such as ester, amides or anhydrides may be suitable for this.
4. Experimental Method - Pericardial Delivery 20 _ A: Polymeric Sheet Rapamycin is combined at concentration range previously highlighted, with a degradable polymer such as poly(caprolactone-gylcolide) or non-degradable polymer, e.g., polydimethylsiloxane, and mixture cast as a thin sheet, thickness range l0u to z5 1000u. The resulting sheet can be wrapped perivascularly on the target vessel. Preference would be for the absorbable polymer.
B: Conformal Coating: Rapamycin is combined with a 3o polymer that has a melting temperature just above 37°C, range 40°-45°C. Mixture is applied in a molten state to the external side of the target vessel. Upon cooling to body temperature the mixture solidifies conformally to the vessel wall. Both non-degradable and absorbable biocompatible polymers are suitable.
As seen in the figures it is also possible to modify currently manufactured stents in order to adequately io provide the drug dosages such as rapamycin. As seen in Figures la, 2a and 3a, any stent strut 10, 20, 30 can be modified to have a certain reservoir or channel 11, 21, 31. Each of these reservoirs can be open or closed as desired. These reservoirs can hold the drug to be delivered. Figure 4 shows a stent 40 with a reservoir 45 created at the apex of a flexible strut. Of course, this reservoir 45 is intended to be useful to deliver rapamycin or any other drug at a specific point of flexibility of the stem . Accordingly, this concept can be useful for "second generation" type stents.
In any of the foregoing devices, however, it is useful to have the drug dosage applied with enough specificity and enough concentration to provide an effective dosage in the lesion area. In this regard, the reservoir size in the stent struts must be kept at a size of about 0.0005" to about 0.003". Then, it should be possible to adequately apply the drug dosage at the desired location and in the desired amount.
These and other concepts will are disclosed herein.
It would be apparent to the reader that modifications are possible to the stent or the drug dosage applied. In any event, however, the any obvious modifications should be s perceived to fall within the scope of the invention which is to be realized from the attached claims and their equivalents.
Claims (3)
PROPERTY OR PRIVILEGE IS CLAIMED ARE DEFINED AS FOLLOWS
1. A stent containing reservoirs for drug delivery.
2. A stent capable of delivering drugs comprising a stent with a reservoir.
3. A stent with a strut containing a channel.
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA002639396A CA2639396A1 (en) | 1998-04-16 | 1999-04-16 | Local delivery of rapamycin for treatment of proliferative sequelae associated with ptca procedures, including delivery using a modified stent |
CA002639393A CA2639393A1 (en) | 1998-04-16 | 1999-04-16 | Local delivery of rapamycin for treatment of proliferative sequelae associated with ptca procedures, including delivery using a modified stent |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/061,568 | 1998-04-16 | ||
US09/061,568 US6273913B1 (en) | 1997-04-18 | 1998-04-16 | Modified stent useful for delivery of drugs along stent strut |
Related Child Applications (2)
Application Number | Title | Priority Date | Filing Date |
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CA002639396A Division CA2639396A1 (en) | 1998-04-16 | 1999-04-16 | Local delivery of rapamycin for treatment of proliferative sequelae associated with ptca procedures, including delivery using a modified stent |
CA002639393A Division CA2639393A1 (en) | 1998-04-16 | 1999-04-16 | Local delivery of rapamycin for treatment of proliferative sequelae associated with ptca procedures, including delivery using a modified stent |
Publications (1)
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CA2269310A1 true CA2269310A1 (en) | 1999-10-16 |
Family
ID=22036624
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CA002639393A Abandoned CA2639393A1 (en) | 1998-04-16 | 1999-04-16 | Local delivery of rapamycin for treatment of proliferative sequelae associated with ptca procedures, including delivery using a modified stent |
CA002639396A Abandoned CA2639396A1 (en) | 1998-04-16 | 1999-04-16 | Local delivery of rapamycin for treatment of proliferative sequelae associated with ptca procedures, including delivery using a modified stent |
CA002269310A Abandoned CA2269310A1 (en) | 1998-04-16 | 1999-04-16 | Local delivery of rapamycin for treatment of proliferative sequelae associated with ptca procedures, including delivery using a modified stent |
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CA002639393A Abandoned CA2639393A1 (en) | 1998-04-16 | 1999-04-16 | Local delivery of rapamycin for treatment of proliferative sequelae associated with ptca procedures, including delivery using a modified stent |
CA002639396A Abandoned CA2639396A1 (en) | 1998-04-16 | 1999-04-16 | Local delivery of rapamycin for treatment of proliferative sequelae associated with ptca procedures, including delivery using a modified stent |
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US (9) | US6273913B1 (en) |
EP (2) | EP0950386B2 (en) |
AT (1) | ATE263520T1 (en) |
CA (3) | CA2639393A1 (en) |
DE (1) | DE69916157T3 (en) |
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PT (1) | PT950386E (en) |
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US6464713B2 (en) * | 1990-06-28 | 2002-10-15 | Peter M. Bonutti | Body tissue fastening |
US7208013B1 (en) | 1990-06-28 | 2007-04-24 | Bonutti Ip, Llc | Composite surgical devices |
US7867275B2 (en) | 1995-06-07 | 2011-01-11 | Cook Incorporated | Coated implantable medical device method |
US7846202B2 (en) * | 1995-06-07 | 2010-12-07 | Cook Incorporated | Coated implantable medical device |
US20070203520A1 (en) * | 1995-06-07 | 2007-08-30 | Dennis Griffin | Endovascular filter |
US7550005B2 (en) * | 1995-06-07 | 2009-06-23 | Cook Incorporated | Coated implantable medical device |
US7896914B2 (en) | 1995-06-07 | 2011-03-01 | Cook Incorporated | Coated implantable medical device |
US7611533B2 (en) * | 1995-06-07 | 2009-11-03 | Cook Incorporated | Coated implantable medical device |
US6774278B1 (en) * | 1995-06-07 | 2004-08-10 | Cook Incorporated | Coated implantable medical device |
US20050152950A1 (en) * | 1995-11-13 | 2005-07-14 | Saffran Bruce N. | Method and apparatus for macromolecular delivery using a coated membrane |
US6777217B1 (en) * | 1996-03-26 | 2004-08-17 | President And Fellows Of Harvard College | Histone deacetylases, and uses related thereto |
US6235053B1 (en) | 1998-02-02 | 2001-05-22 | G. David Jang | Tubular stent consists of chevron-shape expansion struts and contralaterally attached diagonal connectors |
US6783543B2 (en) * | 2000-06-05 | 2004-08-31 | Scimed Life Systems, Inc. | Intravascular stent with increasing coating retaining capacity |
US20040106985A1 (en) | 1996-04-26 | 2004-06-03 | Jang G. David | Intravascular stent |
JP4636634B2 (en) | 1996-04-26 | 2011-02-23 | ボストン サイエンティフィック サイムド,インコーポレイテッド | Intravascular stent |
EP1616563A3 (en) * | 1996-05-24 | 2006-01-25 | Angiotech Pharmaceuticals, Inc. | Perivascular administration of anti-angiogenic factors for treating or preventing vascular diseases |
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1999
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- 1999-04-15 ES ES99302918T patent/ES2218953T5/en not_active Expired - Lifetime
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- 1999-04-15 PT PT99302918T patent/PT950386E/en unknown
- 1999-04-15 DE DE69916157T patent/DE69916157T3/en not_active Expired - Lifetime
- 1999-04-15 AT AT99302918T patent/ATE263520T1/en active
- 1999-04-16 CA CA002639393A patent/CA2639393A1/en not_active Abandoned
- 1999-04-16 CA CA002639396A patent/CA2639396A1/en not_active Abandoned
- 1999-04-16 CA CA002269310A patent/CA2269310A1/en not_active Abandoned
-
2001
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-
2003
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-
2004
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-
2006
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-
2008
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-
2010
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US7223286B2 (en) | 2007-05-29 |
US7217286B2 (en) | 2007-05-15 |
EP0950386A2 (en) | 1999-10-20 |
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PT950386E (en) | 2004-08-31 |
CA2639393A1 (en) | 1999-10-16 |
EP0950386B1 (en) | 2004-04-07 |
US20080317827A1 (en) | 2008-12-25 |
ES2218953T3 (en) | 2004-11-16 |
ES2218953T5 (en) | 2011-11-08 |
CA2639396A1 (en) | 1999-10-16 |
US20050085902A1 (en) | 2005-04-21 |
DE69916157T3 (en) | 2012-02-23 |
US7229473B2 (en) | 2007-06-12 |
EP0950386A3 (en) | 2000-04-05 |
DE69916157T2 (en) | 2005-03-17 |
US20070100436A1 (en) | 2007-05-03 |
US6273913B1 (en) | 2001-08-14 |
EP0950386B2 (en) | 2011-07-13 |
US20030176915A1 (en) | 2003-09-18 |
US20070021825A1 (en) | 2007-01-25 |
US20100239636A1 (en) | 2010-09-23 |
US6585764B2 (en) | 2003-07-01 |
US20010027340A1 (en) | 2001-10-04 |
ATE263520T1 (en) | 2004-04-15 |
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