CA2333360A1 - Augmentation of muscle contractility by biphasic stimulation - Google Patents

Augmentation of muscle contractility by biphasic stimulation Download PDF

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Publication number
CA2333360A1
CA2333360A1 CA002333360A CA2333360A CA2333360A1 CA 2333360 A1 CA2333360 A1 CA 2333360A1 CA 002333360 A CA002333360 A CA 002333360A CA 2333360 A CA2333360 A CA 2333360A CA 2333360 A1 CA2333360 A1 CA 2333360A1
Authority
CA
Canada
Prior art keywords
stimulation
phase
muscle
stimulation phase
amplitude
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002333360A
Other languages
French (fr)
Other versions
CA2333360C (en
Inventor
Morton M. Mower
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MR3 Medical LLC
Original Assignee
Morton M. Mower
Mr3 Medical Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Morton M. Mower, Mr3 Medical Llc filed Critical Morton M. Mower
Publication of CA2333360A1 publication Critical patent/CA2333360A1/en
Application granted granted Critical
Publication of CA2333360C publication Critical patent/CA2333360C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/362—Heart stimulators
    • A61N1/37—Monitoring; Protecting
    • A61N1/3706—Pacemaker parameters
    • A61N1/3708—Pacemaker parameters for power depletion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/36128—Control systems
    • A61N1/36146—Control systems specified by the stimulation parameters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/362—Heart stimulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/362—Heart stimulators
    • A61N1/3627—Heart stimulators for treating a mechanical deficiency of the heart, e.g. congestive heart failure or cardiomyopathy

Abstract

Augmentation of electrical conduction and contractility by biphasic stimulation of muscle tissue. A first stimulation phase has a first phase polarity, amplitude, and duration. The first stimulation phase, which acts as a conditioning mechanism, is administered at no more than a maximum subthreshold amplitude. A second stimulation phase has a second polarity, amplitude, and duration. The two phases are applied sequentially. Contrary to current thought, anodal stimulation is applied as the first stimulation phase, followed by cathodal stimulation as the second stimulation phase. In this fashion, pulse conduction through muscle is improved, together with an increase in contractility. Furthermore, this mode of biphasic stimulation reduces the electrical energy required to elicit contraction. In addition, the conditioning first stimulation phase decreases the stimulation threshold by reducing the amount of electrical current required for the second stimulation phase to elicit contraction. The muscle tissue encompassed by the present invention includes skeletal (striated) muscle, cardiac muscle, and smooth muscle.
CA002333360A 1998-05-27 1999-05-21 Augmentation of muscle contractility by biphasic stimulation Expired - Fee Related CA2333360C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/085,360 1998-05-27
US09/085,360 US6141587A (en) 1996-08-19 1998-05-27 Augmentation of muscle contractility by biphasic stimulation
PCT/US1999/011376 WO1999061100A1 (en) 1998-05-27 1999-05-21 Augmentation of muscle contractility by biphasic stimulation

Publications (2)

Publication Number Publication Date
CA2333360A1 true CA2333360A1 (en) 1999-12-02
CA2333360C CA2333360C (en) 2003-11-25

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
CA002333360A Expired - Fee Related CA2333360C (en) 1998-05-27 1999-05-21 Augmentation of muscle contractility by biphasic stimulation

Country Status (22)

Country Link
US (1) US6141587A (en)
EP (1) EP1079892B1 (en)
JP (3) JP2002516161A (en)
KR (1) KR100433089B1 (en)
CN (1) CN1217718C (en)
AT (1) ATE300973T1 (en)
AU (1) AU749212B2 (en)
BR (1) BR9910731A (en)
CA (1) CA2333360C (en)
DE (1) DE69926501T2 (en)
EA (1) EA004166B1 (en)
ES (1) ES2246087T3 (en)
HU (1) HUP0102736A3 (en)
ID (1) ID27941A (en)
IL (1) IL139917A (en)
NO (1) NO20005958L (en)
NZ (1) NZ530452A (en)
PL (1) PL193803B1 (en)
SK (1) SK286262B6 (en)
TR (1) TR200003494T2 (en)
UA (1) UA66384C2 (en)
WO (1) WO1999061100A1 (en)

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Also Published As

Publication number Publication date
IL139917A0 (en) 2002-02-10
PL193803B1 (en) 2007-03-30
JP2002516161A (en) 2002-06-04
HUP0102736A2 (en) 2001-12-28
SK17902000A3 (en) 2001-07-10
JP2006116332A (en) 2006-05-11
KR100433089B1 (en) 2004-05-27
EP1079892A1 (en) 2001-03-07
CA2333360C (en) 2003-11-25
US6141587A (en) 2000-10-31
ES2246087T3 (en) 2006-02-01
PL344394A1 (en) 2001-11-05
DE69926501D1 (en) 2005-09-08
KR20010074500A (en) 2001-08-04
ATE300973T1 (en) 2005-08-15
TR200003494T2 (en) 2001-04-20
WO1999061100A1 (en) 1999-12-02
JP2004167280A (en) 2004-06-17
UA66384C2 (en) 2004-05-17
CN1217718C (en) 2005-09-07
AU749212B2 (en) 2002-06-20
BR9910731A (en) 2001-02-13
AU4095299A (en) 1999-12-13
IL139917A (en) 2006-12-10
CN1309575A (en) 2001-08-22
EP1079892B1 (en) 2005-08-03
NO20005958L (en) 2001-01-26
ID27941A (en) 2001-05-03
NO20005958D0 (en) 2000-11-24
SK286262B6 (en) 2008-06-06
EA004166B1 (en) 2004-02-26
DE69926501T2 (en) 2006-06-01
NZ530452A (en) 2005-11-25
EA200001226A1 (en) 2002-04-25
HUP0102736A3 (en) 2002-02-28

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