CA2357980A1 - Malleable paste with allograft bone reinforcement for filling bone defects - Google Patents
Malleable paste with allograft bone reinforcement for filling bone defects Download PDFInfo
- Publication number
- CA2357980A1 CA2357980A1 CA002357980A CA2357980A CA2357980A1 CA 2357980 A1 CA2357980 A1 CA 2357980A1 CA 002357980 A CA002357980 A CA 002357980A CA 2357980 A CA2357980 A CA 2357980A CA 2357980 A1 CA2357980 A1 CA 2357980A1
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- Prior art keywords
- bone
- composition
- ranging
- sterile malleable
- rods
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/32—Bones; Osteocytes; Osteoblasts; Tendons; Tenocytes; Teeth; Odontoblasts; Cartilage; Chondrocytes; Synovial membrane
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- A—HUMAN NECESSITIES
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- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/28—Bones
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- A—HUMAN NECESSITIES
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- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1875—Bone morphogenic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
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- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/0047—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
- A61L24/0073—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material with a macromolecular matrix
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- A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
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- A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
- A61L27/48—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with macromolecular fillers
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- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
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- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
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- A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
- A61B17/68—Internal fixation devices, including fasteners and spinal fixators, even if a part thereof projects from the skin
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- A61B17/86—Pins or screws or threaded wires; nuts therefor
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- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
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- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/30767—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
- A61F2/30771—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth applied in original prostheses, e.g. holes or grooves
- A61F2002/30878—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth applied in original prostheses, e.g. holes or grooves with non-sharp protrusions, for instance contacting the bone for anchoring, e.g. keels, pegs, pins, posts, shanks, stems, struts
- A61F2002/30891—Plurality of protrusions
- A61F2002/30894—Plurality of protrusions inclined obliquely with respect to each other
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2230/0063—Three-dimensional shapes
- A61F2230/0065—Three-dimensional shapes toroidal, e.g. ring-shaped, doughnut-shaped
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2230/0063—Three-dimensional shapes
- A61F2230/0069—Three-dimensional shapes cylindrical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2230/0063—Three-dimensional shapes
- A61F2230/0082—Three-dimensional shapes parallelepipedal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
- A61F2310/00005—The prosthesis being constructed from a particular material
- A61F2310/00179—Ceramics or ceramic-like structures
- A61F2310/00293—Ceramics or ceramic-like structures containing a phosphorus-containing compound, e.g. apatite
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
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Abstract
The invention is directed toward a sterile malleable bone composition for application to a bone defect site to promote new bone growth at the site comprising a mixture of demineralized osteogenic bone powder with a particle size ranging from about 250 to about 750 microns and surface demineralized cortical bone rods having a diameter ranging from 1.0mm to 5.00mm or larger bone chips.
The surface demineralized cortical bone rods have diameter to length ratio ranging from 1:2 to 1:20.
The demineralized bone powder range from about 25 to about 30% of the weight of the composition and the cortical bone rods range from 5% to about 10% of the weight of the composition with the carrier being selected from the high molecular weight hydrogel in aqueous solution having a high molecular weight over 700,000 Daltons and ranging from about 2.0% to about 5.0% by weight of the carrier solution.
The surface demineralized cortical bone rods have diameter to length ratio ranging from 1:2 to 1:20.
The demineralized bone powder range from about 25 to about 30% of the weight of the composition and the cortical bone rods range from 5% to about 10% of the weight of the composition with the carrier being selected from the high molecular weight hydrogel in aqueous solution having a high molecular weight over 700,000 Daltons and ranging from about 2.0% to about 5.0% by weight of the carrier solution.
Claims (51)
1. A sterile malleable bone composition for application to a bone defect site to promote new bone growth at the site comprising a mixture of demineralized osteogenic or osteoconductive bone powder with a particle size ranging from about 250 to about 750 microns and osteogenic bone chips of a larger size ranging from 0.1 to 10 mm in a carrier, the demineralized bone powder ranging from about 15% to about 35% of the weight of the composition and the osteogenic bone chips ranging from 5%
to about 20% of the weight of the composition, the Garner being selected from a aqueous sodium based phosphate buffered solution and a hydrogel consisting of a mucopolysaccharide, said mucopolysaccharide having a high molecular weight ranging from seven hundred thousand to three million Daltons and ranging from about 2.0% to about 5.0% by weight of the carrier solution, said composition having a pH ranging from about 7.2 to about 7.4.
to about 20% of the weight of the composition, the Garner being selected from a aqueous sodium based phosphate buffered solution and a hydrogel consisting of a mucopolysaccharide, said mucopolysaccharide having a high molecular weight ranging from seven hundred thousand to three million Daltons and ranging from about 2.0% to about 5.0% by weight of the carrier solution, said composition having a pH ranging from about 7.2 to about 7.4.
2. A sterile malleable bone composition as claimed in claim 1 wherein said composition includes bone morphogenic proteins in excess of the amount naturally occurring in allogeneic bone.
3. A sterile malleable bone composition as claimed in claim 1 wherein said phosphate includes two phosphate ions HPO4 -2 and H2PO4 -1.
4. A sterile malleable bone composition as claimed in claim 1 wherein said composition has an isotonic state of about 300 mOsmol/Kg.
5. A sterile malleable bone composition as claimed in claim 1 including the addition of a calcium salt to the carrier.
6. A sterile malleable bone composition as claimed in claim 1 wherein the balance of the carrier formulation contains a sodium phosphate buffer and has a pH of about
7.2.
7. A sterile malleable bone composition as claimed in claim 1 wherein said bone powder is cortical allograft bone powder.
7. A sterile malleable bone composition as claimed in claim 1 wherein said bone powder is cortical allograft bone powder.
8. A sterile malleable bone composition as claimed in claim 1 wherein said bone powder is cortical-cancellous allograft bone powder.
9. A sterile malleable bone composition as claimed in claim 1 wherein said bone chips are cortical allograft bone chips.
10. A sterile malleable bone composition as claimed in claim 1 wherein said bone chips are cortical-cancellous allograft bone chips.
11. A sterile malleable bone composition as claimed in claim 1 wherein said bone chips are mineralized allograft bone chips.
12. A sterile malleable bone composition as claimed in claim 1 wherein said bone chips are demineralized allograft bone chips.
13. A sterile malleable bone composition as claimed in claim 1 including antimicrobial and/or antibiotics such as erythromycin, bacitracin, neomycin, penicillin, polymyxin B, tetracycline, viomycin, chloromycetin and streptomycin, cefazolin, ampicillin, azactam, tobramycin, clindamycin and gentamycin.
14. A sterile malleable bone composition as claimed in claim 1 wherein said hydrogel is sodium hyaluronate.
15. A sterile malleable bone composition as claimed in claim 1 wherein said hydrogel is chitosan.
16. A sterile malleable bone composition as claimed in claim 1 wherein said hydrogel is carboxy-methyl-cellulose.
17. A sterile malleable bone composition as claimed in claim 1 wherein said composition has a pH ranging from 6.8 to 7.4.
18. A sterile malleable bone composition as claimed in claim 1 wherein the aqueous solution includes an ionic salt based phosphate buffer.
19. A sterile malleable bone composition as claimed in claim 1 wherein said hydrogel has a molecular weight in excess of 700,000 Daltons.
20. A sterile malleable bone composition as claimed in claim 1 wherein said hydrogel has a molecular weight in excess of 1,000,000 Daltons.
21. A sterile malleable bone composition as claimed in claim 1 wherein said hydrogel consists of the group of sodium hyaluronate, chitosan and carboxy-methyl-cellulose.
22. A sterile malleable bone composition as claimed in claim 1 wherein said hydrogel substantially maintains its viscosity from 22-37 degrees C.
23. A sterile malleable bone composition as claimed in claim 1 wherein said aqueous solution is saline.
24. A sterile malleable bone composition for application to a bone defect site to promote new bone growth at the site comprising a carrier and a mixture of demineralized osteogenic bone powder with a particle size ranging from about 250 to about 1000 microns and cortical bone rods having a length ranging from 1 mm to about 10mm and a thickness to length ratio ranging of about 1:2 to 1:20, the demineralized bone powder ranging from about 15 to about 30% of the weight of the composition and the cortical bone rods ranging from 5% to about 20% of the weight of the composition, said carrier comprising a hydrogel selected from a group consisting of sodium hyaluronate, chitosan and carboxy-methyl-cellulose in saline phosphate buffer solution, said hydrogel having a high molecular weight ranging from about seven hundred thousand to about three million Daltons and ranging from about 2.0% to about 5.0% by weight of the carrier solution, said composition having a substantially neutral osmolality.
25. A sterile malleable bone composition as claimed in claim 24 wherein said composition mixture includes bone morphogenic proteins in excess of the amount naturally occurring in allogeneic bone.
26. A sterile malleable bone composition as claimed in claim 24 wherein said phosphate buffer includes two phosphate ions HPO4 -2 and H2PO4 -1.
27. A sterile malleable bone composition as claimed in claim 24 wherein said composition has an isotonic state of about 300 mOsmol/Kg.
28. A sterile malleable bone composition as claimed in claim 24 wherein said bone rods are orientated in substantially one direction in said composition.
29. A sterile malleable bone composition as claimed in claim 24 including antimicrobial and/or antibiotics such as erythromycin, bacitracin, neomycin, penicillin, polymyxin B, tetracycline, viomycin, chloromycetin and streptomycin, cefazolin, ampicillin, azactam, tobramycin, clindamycin and gentamycin.
30. A sterile malleable bone composition as claimed in claim 24 wherein said hydrogel has a molecular weight in excess of one million Daltons.
31. A sterile malleable bone composition as claimed in claim 24 wherein said hydrogel consists of the group of sodium hyaluronate, chitosan and carboxy-methyl-cellulose.
32. A sterile malleable bone composition as claimed in claim 24 wherein said bone rods have a diameter ranging from 0.4mm to about 2.0mm
33. A sterile malleable bone composition as claimed in claim 24 wherein said cortical bone rods are partially demineralized.
34. A sterile malleable bone composition as claimed in claim 33 wherein said bone rods have a diameter ranging from 3.0mm to about 5.00mm.
35. A sterile malleable bone composition as claimed in claim 24 wherein said cortical bone rods are fully demineralized and flexible.
36. A sterile malleable bone composition as claimed in claim 24 wherein said cortical bone rods are randomly orientated in said composition.
37. A sterile malleable bone composition for application to a bone defect site to promote new bone growth at the site comprising a carrier and a mixture of demineralized osteogenic bone powder with a particle size ranging from about 250 to about 750 microns and surface demineralized cortical bone rods having a diameter ranging from 1.0mm to 5.00mm with a diameter to length ratio ranging from 1:2 to 1:20, the demineralized bone powder ranging from about 25 to about 30% of the weight of the composition and the cortical bone rods ranging from 5% to about 10% of the weight of the composition, said carrier comprising a high molecular weight hydrogel mucosaccharide in aqueous phosphate buffered solution, said mucosaccharide having a high molecular weight over 700,000 Daltons and ranging from about 2.0% to about 5.0% by weight of the carrier solution.
38. A sterile malleable bone composition as claimed in claim 37 wherein said cortical bone rods are randomly oriented in said composition.
39. A sterile malleable bone composition as claimed in claim 37 wherein said cortical bone rods are oriented in substantially one direction in said composition.
40. A sterile malleable bone composition for application to a bone defect site to promote new bone growth at the site comprising a carrier and a mixture of demineralized osteogenic bone powder with a particle size ranging from about 250 to about 1000 microns and mineralized cortical bone rods having a diameter ranging from 0.4 to about 2.0 mm and a diameter to length ratio of about 2- to about 6, the demineralized bone powder ranging from about 25 to about 35% of the weight of the composition and the mineralized cortical rods ranging from 5% to about 25% of the weight of the composition, said carrier comprising a hydrogel selected from a group consisting of sodium hyaluronate, chitosan and carboxy-methyl-cellulose in a buffered phosphate saline solution, said hydrogel having a high molecular weight of at least 1.0 x 106 Daltons and ranging from about 1.0% to about 5.0% by weight of the carrier solution.
41. A sterile malleable bone putty composition for application to a bone defect site to promote new bone growth at the site which comprises a new bone growth inducing mixture of demineralized lyophilized allograft bone powder with a particle size ranging from about 250 to about 750 microns and mineralized cortical allograft bone chips ranging from 1.0mm to 10.00 mm in size and cortical bone rods in a hyaluronic acid saline phosphate buffer carrier, the hyaluronic acid component ranging from above 2.0% to about 5% of the carrier solution and having a molecular weight of at least 6 Daltons, the total bone content of the bone powder, bone chips and bone rods in the carrier ranging in weight from about 30% to about 50% total weight of the composition.
42. A sterile malleable bone putty composition for application to a bone defect site to promote new bone growth at the site comprising a new bone growth inducing demineralized lyophilized allograft bone powder with a particle size ranging from about 250 to about 750 microns and mineralized bone chips ranging from 0.1mm - 10mm in a high molecular weight sodium hyaluronate and saline carrier with a phosphate buffer, the bone content of the composition ranging from about 25% to about 45% by weight and the high molecular weight sodium hyaluronate component ranges from about 2%
to about 5% of the carrier and has a molecular weight greater than one million Daltons.
to about 5% of the carrier and has a molecular weight greater than one million Daltons.
43. A sterile malleable bone putty composition for application to a bone defect site to promote new bone growth at the site which comprises a new bone growth inducing demineralized lyophilized allograft bone powder with a particle size ranging from about 250 to about 750 microns and mineralized bone chips ranging from 1 - 10mm in size in a carrier solution, said carrier solution comprising a high molecular weight chitosan having a molecular weight over 1.0 x 10 5 Daltons in an aqueous buffered phosphate with the bone content of the putty composition ranging from about 30%
to about 35% and the chitosan component ranging from 2 to 5% of the carrier solution and said composition having a substantially neutral osmolality.
to about 35% and the chitosan component ranging from 2 to 5% of the carrier solution and said composition having a substantially neutral osmolality.
44. A sterile malleable bone putty composition for application to a bone defect site to promote new bone growth at the site which comprises a new bone growth inducing demineralized lyophilized allografr bone powder with a particle size ranging from about 250 to about 750 microns and mineralized bone cortical bone rods having a diameter to length ratio ranging from 1:2 - 1:20mm in length in a carrier, said carrier comprising a high molecular weight chitosan having a molecular weight over 1.0 x 10 6 Daltons in a water phosphate buffered solution with the bone content of the putty composition ranging from about 30% to about 35% and the chitosan component ranging from 2 to 5%
of the carrier solution.
of the carrier solution.
45. A sterile malleable bone putty as claimed in claim 44 wherein said cortical bone rods are mineralized.
46. A sterile malleable bone putty as claimed in claim 44 wherein said cortical bone rods are partially demineralized.
47. A sterile malleable bone putty as claimed in claim 44 wherein said cortical bone rods are fully demineralized.
48. A sterile malleable bone putty composition for application to a bone defect site to promote new bone growth at the site which comprises a new bone growth inducing demineralized lyophilized allograft bone powder with a particle size ranging from about 250 to about 750 microns and mineralized bone cortical bone rods having a diameter to length ratio ranging from 1:2 - 1:20mm in length in a high molecular weight carboxy-methyl-cellulose phosphate buffered water Garner solution with the bone content of the putty composition ranging from about 30% to about 35% and the carboxy-methyl-cellulose component ranging from 2 to 5% of the carrier solution.
49. A sterile malleable bone putty as claimed in claim 48 wherein said cortical bone rods are mineralized.
50. A sterile malleable bone putty as claimed in claim 48 wherein said cortical bone rods are partially demineralized.
51. A sterile malleable bone putty as claimed in claim 48 wherein said cortical bone rods are fully demineralized.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/677,891 | 2000-10-03 | ||
US09/677,891 US6458375B1 (en) | 1998-02-27 | 2000-10-03 | Malleable paste with allograft bone reinforcement for filling bone defects |
Publications (2)
Publication Number | Publication Date |
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CA2357980A1 true CA2357980A1 (en) | 2002-04-03 |
CA2357980C CA2357980C (en) | 2009-12-22 |
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Application Number | Title | Priority Date | Filing Date |
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CA002357980A Expired - Lifetime CA2357980C (en) | 2000-10-03 | 2001-10-02 | Malleable paste with allograft bone reinforcement for filling bone defects |
Country Status (5)
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US (1) | US6458375B1 (en) |
EP (1) | EP1263365A4 (en) |
AU (1) | AU782504B2 (en) |
CA (1) | CA2357980C (en) |
WO (1) | WO2002028332A1 (en) |
Families Citing this family (115)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7019192B2 (en) * | 1998-02-27 | 2006-03-28 | Musculoskeletal Transplant Foundation | Composition for filling bone defects |
US20030147860A1 (en) * | 2002-02-07 | 2003-08-07 | Marchosky J. Alexander | Compositions and methods for forming and strengthening bone |
US20040097996A1 (en) | 1999-10-05 | 2004-05-20 | Omnisonics Medical Technologies, Inc. | Apparatus and method of removing occlusions using an ultrasonic medical device operating in a transverse mode |
US20030228288A1 (en) | 1999-10-15 | 2003-12-11 | Scarborough Nelson L. | Volume maintaining osteoinductive/osteoconductive compositions |
AR027685A1 (en) * | 2000-03-22 | 2003-04-09 | Synthes Ag | METHOD AND METHOD FOR CARRYING OUT |
EP1280564B1 (en) * | 2000-05-12 | 2005-08-31 | Osteotech, Inc. | Surface demineralized osteoimplant and method for making same |
US9387094B2 (en) * | 2000-07-19 | 2016-07-12 | Warsaw Orthopedic, Inc. | Osteoimplant and method of making same |
US7323193B2 (en) | 2001-12-14 | 2008-01-29 | Osteotech, Inc. | Method of making demineralized bone particles |
US7132110B2 (en) * | 2001-08-30 | 2006-11-07 | Isotis Orthobiologics, Inc. | Tissue repair compositions and methods for their manufacture and use |
US7163691B2 (en) | 2001-10-12 | 2007-01-16 | Osteotech, Inc. | Bone graft |
AU2002366381A1 (en) * | 2001-12-18 | 2003-06-30 | Ebi, L.P. | Spinal implants |
TW200400062A (en) | 2002-04-03 | 2004-01-01 | Mathys Medizinaltechnik Ag | Kneadable, pliable bone replacement material |
US20060204544A1 (en) * | 2002-05-20 | 2006-09-14 | Musculoskeletal Transplant Foundation | Allograft bone composition having a gelatin binder |
US7744597B2 (en) * | 2002-06-26 | 2010-06-29 | Lifenet Health | Device and process for producing fiber products and fiber products produced thereby |
US7498040B2 (en) | 2005-10-12 | 2009-03-03 | Lifenet Health | Compositions for repair of defects in osseous tissues, and methods of making the same |
US7842300B2 (en) * | 2002-07-31 | 2010-11-30 | Dentsply International, Inc. | Bone repair putty |
US8876532B2 (en) | 2002-07-31 | 2014-11-04 | Dentsply International Inc. | Bone repair putty |
US7374776B2 (en) * | 2002-09-30 | 2008-05-20 | Regen Biotech, Inc. | Bone-filling composition for stimulating bone-forming and bone-consolidation comprising calcium sulfate and viscous biopolymers |
KR101161784B1 (en) * | 2003-04-11 | 2012-07-05 | 에텍스 코포레이션 | Osteoinductive Bone Material |
US7067123B2 (en) | 2003-04-29 | 2006-06-27 | Musculoskeletal Transplant Foundation | Glue for cartilage repair |
US7494811B2 (en) * | 2003-05-01 | 2009-02-24 | Lifenet Health | In vitro growth of tissues suitable to the formation of bone and bone forming tissue formed thereby |
US7901457B2 (en) | 2003-05-16 | 2011-03-08 | Musculoskeletal Transplant Foundation | Cartilage allograft plug |
AU2004247143B2 (en) | 2003-06-11 | 2010-09-23 | Warsaw Orthopedic, Inc. | Osteoimplants and methods for their manufacture |
US20050020506A1 (en) * | 2003-07-25 | 2005-01-27 | Drapeau Susan J. | Crosslinked compositions comprising collagen and demineralized bone matrix, methods of making and methods of use |
US7955616B2 (en) * | 2003-09-23 | 2011-06-07 | Orthocon, Inc. | Absorbable implants and methods for their use in hemostasis and in the treatment of osseous defects |
US7794414B2 (en) | 2004-02-09 | 2010-09-14 | Emigrant Bank, N.A. | Apparatus and method for an ultrasonic medical device operating in torsional and transverse modes |
US7621952B2 (en) * | 2004-06-07 | 2009-11-24 | Dfine, Inc. | Implants and methods for treating bone |
US20060095138A1 (en) | 2004-06-09 | 2006-05-04 | Csaba Truckai | Composites and methods for treating bone |
US20060085009A1 (en) * | 2004-08-09 | 2006-04-20 | Csaba Truckai | Implants and methods for treating bone |
US7837740B2 (en) | 2007-01-24 | 2010-11-23 | Musculoskeletal Transplant Foundation | Two piece cancellous construct for cartilage repair |
US20060083769A1 (en) * | 2004-10-14 | 2006-04-20 | Mukesh Kumar | Method and apparatus for preparing bone |
US7670384B2 (en) * | 2004-10-14 | 2010-03-02 | Biomet Manufacturing Corp. | Bone graft composition comprising a bone material and a carrier comprising denatured demineralized bone |
US20060100547A1 (en) * | 2004-10-27 | 2006-05-11 | Omnisonics Medical Technologies, Inc. | Apparatus and method for using an ultrasonic medical device to reinforce bone |
US7559932B2 (en) | 2004-12-06 | 2009-07-14 | Dfine, Inc. | Bone treatment systems and methods |
US8048083B2 (en) | 2004-11-05 | 2011-11-01 | Dfine, Inc. | Bone treatment systems and methods |
US8663225B2 (en) * | 2004-11-12 | 2014-03-04 | Medtronic, Inc. | Hydrogel bone void filler |
US8070753B2 (en) | 2004-12-06 | 2011-12-06 | Dfine, Inc. | Bone treatment systems and methods |
US7722620B2 (en) | 2004-12-06 | 2010-05-25 | Dfine, Inc. | Bone treatment systems and methods |
US20060233849A1 (en) * | 2005-04-13 | 2006-10-19 | Simon Bruce J | Composite bone graft material |
US7621963B2 (en) * | 2005-04-13 | 2009-11-24 | Ebi, Llc | Composite bone graft material |
US7815926B2 (en) | 2005-07-11 | 2010-10-19 | Musculoskeletal Transplant Foundation | Implant for articular cartilage repair |
CA2623106C (en) | 2005-09-19 | 2013-12-24 | Histogenics Corporation | Cell-support matrix having narrowly defined uniformly vertically and non-randomly organized porosity and pore density and a method for preparation thereof |
US9005646B2 (en) | 2005-10-12 | 2015-04-14 | Lifenet Health | Compositions for repair of defects in tissues, and methods of making the same |
US20070083270A1 (en) * | 2005-10-12 | 2007-04-12 | Leila Masinaei | Orthopedic prosthetic devices containing compositions for repair of defects in osseous tissues |
US7498041B2 (en) * | 2005-10-12 | 2009-03-03 | Lifenet Health | Composition for repair of defects in osseous tissues |
WO2007056671A1 (en) | 2005-11-02 | 2007-05-18 | Osteotech, Inc. | Hemostatic bone graft |
US20070233249A1 (en) * | 2006-02-07 | 2007-10-04 | Shadduck John H | Methods for treating bone |
WO2007127255A2 (en) | 2006-04-26 | 2007-11-08 | Illuminoss Medical, Inc. | Apparatus and methods for reinforcing bone |
US7806900B2 (en) | 2006-04-26 | 2010-10-05 | Illuminoss Medical, Inc. | Apparatus and methods for delivery of reinforcing materials to bone |
US7771741B2 (en) * | 2006-05-01 | 2010-08-10 | Warsaw Orthopedic, Inc | Demineralized bone matrix devices |
US7838022B2 (en) | 2006-05-01 | 2010-11-23 | Warsaw Orthopedic, Inc | Malleable implants containing demineralized bone matrix |
US8506983B2 (en) * | 2006-05-01 | 2013-08-13 | Warsaw Orthopedic, Inc. | Bone filler material |
US20100209470A1 (en) * | 2006-05-01 | 2010-08-19 | Warsaw Orthopedic, Inc. An Indiana Corporation | Demineralized bone matrix devices |
US9066994B2 (en) | 2006-08-31 | 2015-06-30 | Warsaw Orthopedic, Inc. | Demineralized cancellous strip DBM graft |
US7879041B2 (en) | 2006-11-10 | 2011-02-01 | Illuminoss Medical, Inc. | Systems and methods for internal bone fixation |
ES2533700T3 (en) | 2006-11-10 | 2015-04-14 | Illuminoss Medical, Inc. | Systems for internal bone fixation |
US8696679B2 (en) | 2006-12-08 | 2014-04-15 | Dfine, Inc. | Bone treatment systems and methods |
US8435551B2 (en) | 2007-03-06 | 2013-05-07 | Musculoskeletal Transplant Foundation | Cancellous construct with support ring for repair of osteochondral defects |
US9492278B2 (en) * | 2007-07-10 | 2016-11-15 | Warsaw Orthopedic, Inc. | Delivery system |
US9597118B2 (en) | 2007-07-20 | 2017-03-21 | Dfine, Inc. | Bone anchor apparatus and method |
US9138509B2 (en) | 2007-09-14 | 2015-09-22 | Musculoskeletal Transplant Foundation | Composition for filling bone defects |
US9427289B2 (en) | 2007-10-31 | 2016-08-30 | Illuminoss Medical, Inc. | Light source |
US9056150B2 (en) | 2007-12-04 | 2015-06-16 | Warsaw Orthopedic, Inc. | Compositions for treating bone defects |
US8403968B2 (en) | 2007-12-26 | 2013-03-26 | Illuminoss Medical, Inc. | Apparatus and methods for repairing craniomaxillofacial bones using customized bone plates |
US9445854B2 (en) | 2008-02-01 | 2016-09-20 | Dfine, Inc. | Bone treatment systems and methods |
JP5509098B2 (en) | 2008-02-28 | 2014-06-04 | ディーエフアイエヌイー・インコーポレーテッド | Bone treatment system and method |
WO2009111069A1 (en) | 2008-03-05 | 2009-09-11 | Musculoskeletal Transplant Foundation | Cancellous constructs, cartilage particles and combinations of cancellous constructs and cartilage particles |
US8840913B2 (en) | 2008-03-27 | 2014-09-23 | Warsaw Orthopedic, Inc. | Malleable multi-component implants and materials therefor |
CA2742047A1 (en) | 2008-10-24 | 2010-04-29 | Warsaw Orthopedic, Inc. | Compositions and methods for promoting bone formation |
US8210729B2 (en) | 2009-04-06 | 2012-07-03 | Illuminoss Medical, Inc. | Attachment system for light-conducting fibers |
US8512338B2 (en) | 2009-04-07 | 2013-08-20 | Illuminoss Medical, Inc. | Photodynamic bone stabilization systems and methods for reinforcing bone |
US8870965B2 (en) | 2009-08-19 | 2014-10-28 | Illuminoss Medical, Inc. | Devices and methods for bone alignment, stabilization and distraction |
US20110060412A1 (en) * | 2009-09-08 | 2011-03-10 | Musculoskeletal Transplant Foundation Inc. | Tissue Engineered Meniscus Repair Composition |
WO2011031637A2 (en) * | 2009-09-08 | 2011-03-17 | Musculoskeletal Transplant Foundation Inc. | Tissue engineered meniscus repair composition |
US8795727B2 (en) | 2009-11-09 | 2014-08-05 | Spotlight Technology Partners Llc | Fragmented hydrogels |
US9700650B2 (en) | 2009-11-09 | 2017-07-11 | Spotlight Technology Partners Llc | Polysaccharide based hydrogels |
FR2955258A1 (en) * | 2010-01-20 | 2011-07-22 | Biopharmex Holding Ltd | INJECTABLE COMPOSITION |
US9352003B1 (en) | 2010-05-14 | 2016-05-31 | Musculoskeletal Transplant Foundation | Tissue-derived tissuegenic implants, and methods of fabricating and using same |
US10130736B1 (en) | 2010-05-14 | 2018-11-20 | Musculoskeletal Transplant Foundation | Tissue-derived tissuegenic implants, and methods of fabricating and using same |
US8684965B2 (en) | 2010-06-21 | 2014-04-01 | Illuminoss Medical, Inc. | Photodynamic bone stabilization and drug delivery systems |
US8926710B2 (en) * | 2010-10-25 | 2015-01-06 | Warsaw Orthopedic, Inc. | Osteoinductive bone graft injectable cement |
US9044722B2 (en) | 2010-11-10 | 2015-06-02 | Darren Edward Nolen | Multi-component, temperature activated, tissue adhesive, sealing, and filling composition |
US9179959B2 (en) | 2010-12-22 | 2015-11-10 | Illuminoss Medical, Inc. | Systems and methods for treating conditions and diseases of the spine |
US8398611B2 (en) | 2010-12-28 | 2013-03-19 | Depuy Mitek, Inc. | Compositions and methods for treating joints |
US8455436B2 (en) | 2010-12-28 | 2013-06-04 | Depuy Mitek, Llc | Compositions and methods for treating joints |
US8524662B2 (en) | 2010-12-28 | 2013-09-03 | Depuy Mitek, Llc | Compositions and methods for treating joints |
US8623839B2 (en) | 2011-06-30 | 2014-01-07 | Depuy Mitek, Llc | Compositions and methods for stabilized polysaccharide formulations |
US8936644B2 (en) | 2011-07-19 | 2015-01-20 | Illuminoss Medical, Inc. | Systems and methods for joint stabilization |
US9775661B2 (en) | 2011-07-19 | 2017-10-03 | Illuminoss Medical, Inc. | Devices and methods for bone restructure and stabilization |
US20130189338A1 (en) * | 2012-01-19 | 2013-07-25 | Warsaw Orthopedic, Inc. | Bone fibers having extended length |
US8939977B2 (en) | 2012-07-10 | 2015-01-27 | Illuminoss Medical, Inc. | Systems and methods for separating bone fixation devices from introducer |
US10172651B2 (en) | 2012-10-25 | 2019-01-08 | Warsaw Orthopedic, Inc. | Cortical bone implant |
US9687281B2 (en) | 2012-12-20 | 2017-06-27 | Illuminoss Medical, Inc. | Distal tip for bone fixation devices |
US9265609B2 (en) | 2013-01-08 | 2016-02-23 | Warsaw Orthopedic, Inc. | Osteograft implant |
US20140212499A1 (en) * | 2013-01-25 | 2014-07-31 | Biomet Manufacturing, Llc | Compositions and methods for repairing bone |
TW201521729A (en) | 2013-03-15 | 2015-06-16 | Theocorp Holdings Co Llc | Theobromine compositions useful for increasing fetal weight gain and enhancing bone properties |
AU2014253753B2 (en) | 2013-04-19 | 2017-03-30 | Theracell, Inc. | Demineralized bone fibers having controlled geometry and shapes and methods thereof |
US20150050358A1 (en) * | 2013-08-15 | 2015-02-19 | Regents Of The University Of Minnesota | Implant support composition and methods of use |
US9486483B2 (en) * | 2013-10-18 | 2016-11-08 | Globus Medical, Inc. | Bone grafts including osteogenic stem cells, and methods relating to the same |
US9539286B2 (en) * | 2013-10-18 | 2017-01-10 | Globus Medical, Inc. | Bone grafts including osteogenic stem cells, and methods relating to the same |
US9192692B2 (en) | 2013-10-24 | 2015-11-24 | Medtronic Xomed, Inc. | Chitosan stenting paste |
US9192574B2 (en) | 2013-10-24 | 2015-11-24 | Medtronic Xomed, Inc. | Chitosan paste wound dressing |
WO2016044030A1 (en) | 2014-09-19 | 2016-03-24 | Osiris Therapeutics, Inc. | Bone repair product and methods of use thereof |
US9623153B2 (en) * | 2014-09-23 | 2017-04-18 | Warsaw Orthopedic, Inc. | Bone graft materials and methods of use |
US10660685B2 (en) | 2014-11-14 | 2020-05-26 | Warsaw Orthopedic, Inc. | Bone graft materials, devices and methods of use |
US10077420B2 (en) | 2014-12-02 | 2018-09-18 | Histogenics Corporation | Cell and tissue culture container |
US9682099B2 (en) | 2015-01-20 | 2017-06-20 | DePuy Synthes Products, Inc. | Compositions and methods for treating joints |
US10531957B2 (en) | 2015-05-21 | 2020-01-14 | Musculoskeletal Transplant Foundation | Modified demineralized cortical bone fibers |
US10463767B2 (en) | 2016-04-22 | 2019-11-05 | Vivex Biologics Group, Inc. | Moldable bone composition |
US11253630B2 (en) | 2016-04-22 | 2022-02-22 | Vivex Biologics Group, Inc. | Malleable demineralized bone composition and method of manufacture |
US10596298B2 (en) | 2016-04-22 | 2020-03-24 | Vivex Biologics Group, Inc. | Malleable demineralized bone composition and method of manufacture |
US9788950B1 (en) * | 2016-04-22 | 2017-10-17 | Vivex Biomedical, Inc. | Cohesive bone composition |
US11253629B2 (en) | 2016-04-22 | 2022-02-22 | Vivex Biologics Group, Inc. | Bone gel sheet composition and method of manufacture |
EP3813696A4 (en) | 2018-06-27 | 2022-04-13 | IlluminOss Medical, Inc. | Systems and methods for bone stabilization and fixation |
US11896736B2 (en) | 2020-07-13 | 2024-02-13 | Globus Medical, Inc | Biomaterial implants and methods of making the same |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4172128A (en) | 1975-03-26 | 1979-10-23 | Erhard Thiele | Process of degrading and regenerating bone and tooth material and products |
US6311690B1 (en) * | 1986-03-27 | 2001-11-06 | Gensci Orthobiologics, Inc. | Bone repair material and delayed drug delivery system |
US5073373A (en) | 1989-09-21 | 1991-12-17 | Osteotech, Inc. | Flowable demineralized bone powder composition and its use in bone repair |
US5290558A (en) | 1989-09-21 | 1994-03-01 | Osteotech, Inc. | Flowable demineralized bone powder composition and its use in bone repair |
FR2655202B1 (en) | 1989-11-24 | 1992-02-07 | Thomson Csf | CIRCULAR POLARIZATION ANTENNA, ESPECIALLY FOR ANTENNA NETWORK. |
US5191747A (en) | 1991-05-08 | 1993-03-09 | Tengquist David C | Prefabricated pass-through service system for fast food restaurants and the like |
US5356629A (en) * | 1991-07-12 | 1994-10-18 | United States Surgical Corporation | Composition for effecting bone repair |
US5314476A (en) | 1992-02-04 | 1994-05-24 | Osteotech, Inc. | Demineralized bone particles and flowable osteogenic composition containing same |
US5507813A (en) | 1993-12-09 | 1996-04-16 | Osteotech, Inc. | Shaped materials derived from elongate bone particles |
US5516532A (en) | 1994-08-05 | 1996-05-14 | Children's Medical Center Corporation | Injectable non-immunogenic cartilage and bone preparation |
TW369414B (en) | 1994-09-30 | 1999-09-11 | Yamanouchi Pharma Co Ltd | Bone formation transplant |
US6165487A (en) | 1996-09-30 | 2000-12-26 | Children's Medical Center Corporation | Methods and compositions for programming an organic matrix for remodeling into a target tissue |
WO1998014222A1 (en) | 1996-09-30 | 1998-04-09 | Children's Medical Center Corporation | Methods and compositions for programming an organic matrix for remodeling into a target tissue |
US5910315A (en) * | 1997-07-18 | 1999-06-08 | Stevenson; Sharon | Allograft tissue material for filling spinal fusion cages or related surgical spaces |
US6309659B1 (en) | 1997-09-02 | 2001-10-30 | Gensci Orthobiologics, Inc. | Reverse phase connective tissue repair composition |
US6030635A (en) * | 1998-02-27 | 2000-02-29 | Musculoskeletal Transplant Foundation | Malleable paste for filling bone defects |
US6340477B1 (en) | 2000-04-27 | 2002-01-22 | Lifenet | Bone matrix composition and methods for making and using same |
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US6458375B1 (en) | 2002-10-01 |
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