CA2393537A1 - Skin treatment apparatus for sustained transdermal drug delivery - Google Patents
Skin treatment apparatus for sustained transdermal drug delivery Download PDFInfo
- Publication number
- CA2393537A1 CA2393537A1 CA002393537A CA2393537A CA2393537A1 CA 2393537 A1 CA2393537 A1 CA 2393537A1 CA 002393537 A CA002393537 A CA 002393537A CA 2393537 A CA2393537 A CA 2393537A CA 2393537 A1 CA2393537 A1 CA 2393537A1
- Authority
- CA
- Canada
- Prior art keywords
- skin
- stretching
- micropathways
- drug delivery
- treatment apparatus
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/20—Surgical instruments, devices or methods, e.g. tourniquets for vaccinating or cleaning the skin previous to the vaccination
- A61B17/205—Vaccinating by means of needles or other puncturing devices
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
- A61M31/002—Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/20—Applying electric currents by contact electrodes continuous direct currents
- A61N1/30—Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
- A61N1/303—Constructional details
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M2037/0007—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin having means for enhancing the permeation of substances through the epidermis, e.g. using suction or depression, electric or magnetic fields, sound waves or chemical agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0023—Drug applicators using microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0046—Solid microneedles
Abstract
An expandable skin stretching device (100) includes skin engaging opposite ends (56, 57) that contact the skin (30) surface on opposite sides of an area of the skin surface having micropathways (31) therein. When the skin stretching device (100) is expanded the skin (30) between the opposite ends (56, 57) is placed under tension, i.e., stretched. The skin is placed under a tension of about 0.01 to about 10 megapascals, preferably about 0.05 to about 2 megapascals. The skin stretching can be uni-directional or multi-directional. Alternative embodiments of skin stretching devices (101, 102, 103, 104, 105) use suction or normal force to stretch the skin (30). Stretching the skin (30) helps keep the micropathways (31) open for enhanced agent (e.g., drug) delivery through the micropathways (31).
The stretching also delays micropathway (31) closure.
The stretching also delays micropathway (31) closure.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US17270499P | 1999-12-10 | 1999-12-10 | |
US60/172,704 | 1999-12-10 | ||
PCT/US2000/033582 WO2001041864A1 (en) | 1999-12-10 | 2000-12-07 | Skin treatment apparatus for sustained transdermal drug delivery |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2393537A1 true CA2393537A1 (en) | 2001-06-14 |
CA2393537C CA2393537C (en) | 2009-02-03 |
Family
ID=22628847
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002393537A Expired - Fee Related CA2393537C (en) | 1999-12-10 | 2000-12-07 | Skin treatment apparatus for sustained transdermal drug delivery |
Country Status (19)
Country | Link |
---|---|
US (2) | US20020111600A1 (en) |
EP (1) | EP1239917B1 (en) |
JP (1) | JP4312407B2 (en) |
KR (1) | KR100832754B1 (en) |
CN (1) | CN100402106C (en) |
AT (1) | ATE295200T1 (en) |
AU (1) | AU782610B2 (en) |
CA (1) | CA2393537C (en) |
DE (1) | DE60020159T2 (en) |
DK (1) | DK1239917T3 (en) |
ES (1) | ES2238333T3 (en) |
HK (1) | HK1048773B (en) |
HU (1) | HU225467B1 (en) |
IL (1) | IL150091A0 (en) |
MX (1) | MXPA02005765A (en) |
NO (1) | NO323128B1 (en) |
PT (1) | PT1239917E (en) |
WO (1) | WO2001041864A1 (en) |
ZA (1) | ZA200204597B (en) |
Families Citing this family (62)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6256533B1 (en) * | 1999-06-09 | 2001-07-03 | The Procter & Gamble Company | Apparatus and method for using an intracutaneous microneedle array |
US6595947B1 (en) * | 2000-05-22 | 2003-07-22 | Becton, Dickinson And Company | Topical delivery of vaccines |
US6440096B1 (en) * | 2000-07-14 | 2002-08-27 | Becton, Dickinson And Co. | Microdevice and method of manufacturing a microdevice |
CA2422200A1 (en) | 2000-09-08 | 2002-03-14 | Alza Corporation | Methods for inhibiting decrease in transdermal drug flux by inhibition of pathway closure |
US7828827B2 (en) | 2002-05-24 | 2010-11-09 | Corium International, Inc. | Method of exfoliation of skin using closely-packed microstructures |
US6821281B2 (en) | 2000-10-16 | 2004-11-23 | The Procter & Gamble Company | Microstructures for treating and conditioning skin |
US6663820B2 (en) * | 2001-03-14 | 2003-12-16 | The Procter & Gamble Company | Method of manufacturing microneedle structures using soft lithography and photolithography |
US20040087992A1 (en) * | 2002-08-09 | 2004-05-06 | Vladimir Gartstein | Microstructures for delivering a composition cutaneously to skin using rotatable structures |
WO2003051284A2 (en) * | 2001-10-29 | 2003-06-26 | Becton, Dickinson And Company | Method and device for the delivery of a substance |
US20040120964A1 (en) * | 2001-10-29 | 2004-06-24 | Mikszta John A. | Needleless vaccination using chimeric yellow fever vaccine-vectored vaccines against heterologous flaviviruses |
CN1618014B (en) * | 2001-11-26 | 2010-04-28 | 索尼国际(欧洲)股份有限公司 | The use of 1d semiconductor materials as chemical sensing materials, production and operation close to room temperature |
AU2004285484A1 (en) * | 2003-10-24 | 2005-05-12 | Alza Corporation | Pretreatment method and system for enhancing transdermal drug delivery |
EP1696983A2 (en) * | 2003-12-18 | 2006-09-06 | Novo Nordisk A/S | Nozzle device with skin stretching means |
EP1706171A1 (en) * | 2003-12-29 | 2006-10-04 | 3M Innovative Properties Company | Medical devices and kits including same |
WO2005094526A2 (en) | 2004-03-24 | 2005-10-13 | Corium International, Inc. | Transdermal delivery device |
US7591806B2 (en) * | 2004-05-18 | 2009-09-22 | Bai Xu | High-aspect-ratio microdevices and methods for transdermal delivery and sampling of active substances |
JP4927752B2 (en) | 2004-11-18 | 2012-05-09 | スリーエム イノベイティブ プロパティズ カンパニー | Microneedle array applicator and holding device |
KR20130026511A (en) | 2004-11-18 | 2013-03-13 | 쓰리엠 이노베이티브 프로퍼티즈 컴파니 | Low-profile microneedle array applicator |
JP5301985B2 (en) | 2005-04-07 | 2013-09-25 | スリーエム イノベイティブ プロパティズ カンパニー | System and method for tool feedback sensing |
US8043250B2 (en) * | 2005-05-18 | 2011-10-25 | Nanomed Devices, Inc. | High-aspect-ratio microdevices and methods for transdermal delivery and sampling of active substances |
US8048017B2 (en) * | 2005-05-18 | 2011-11-01 | Bai Xu | High-aspect-ratio microdevices and methods for transdermal delivery and sampling of active substances |
EP1904158B1 (en) | 2005-06-24 | 2013-07-24 | 3M Innovative Properties Company | Collapsible patch with microneedle array |
JP5144510B2 (en) | 2005-06-27 | 2013-02-13 | スリーエム イノベイティブ プロパティズ カンパニー | Microneedle array application device |
US20070078414A1 (en) * | 2005-08-05 | 2007-04-05 | Mcallister Devin V | Methods and devices for delivering agents across biological barriers |
EP1928537B1 (en) * | 2005-09-02 | 2015-01-21 | Intercell USA, Inc. | Devices for transcutaneous delivery of vaccines and transdermal delivery of drugs |
US8554317B2 (en) * | 2005-11-30 | 2013-10-08 | 3M Innovative Properties Company | Microneedle arrays and methods of use thereof |
WO2007124411A1 (en) * | 2006-04-20 | 2007-11-01 | 3M Innovative Properties Company | Device for applying a microneedle array |
US20080214987A1 (en) * | 2006-12-22 | 2008-09-04 | Nanomed Devices, Inc. | Microdevice And Method For Transdermal Delivery And Sampling Of Active Substances |
US10525246B2 (en) | 2006-12-22 | 2020-01-07 | Nanomed Skincare, Inc. | Microdevice and method for transdermal delivery and sampling of active substances |
WO2008091602A2 (en) | 2007-01-22 | 2008-07-31 | Corium International, Inc. | Applicators for microneedle arrays |
US9114238B2 (en) | 2007-04-16 | 2015-08-25 | Corium International, Inc. | Solvent-cast microprotrusion arrays containing active ingredient |
US8150505B2 (en) * | 2007-05-03 | 2012-04-03 | Path Scientific, Llc | Method and apparatus for the formation of multiple microconduits |
JP2010535591A (en) | 2007-08-06 | 2010-11-25 | トランスダーム, インコーポレイテッド | Microneedle array formed from polymer film |
WO2009048607A1 (en) | 2007-10-10 | 2009-04-16 | Corium International, Inc. | Vaccine delivery via microneedle arrays |
US8940013B2 (en) * | 2007-12-24 | 2015-01-27 | Peter Ar-Fu Lam | Human skin treatment arrangement |
US8876856B2 (en) * | 2007-12-24 | 2014-11-04 | Peter Ar-Fu Lam | Human skin treatment arrangement |
US9066738B2 (en) * | 2008-07-14 | 2015-06-30 | Syneron Medical Ltd. | Devices and methods for percutaneous energy delivery |
WO2011140274A2 (en) | 2010-05-04 | 2011-11-10 | Corium International, Inc. | Method and device for transdermal delivery of parathyroid hormone using a microprojection array |
US20130012891A1 (en) * | 2011-07-05 | 2013-01-10 | Yossi Gross | Skin-treatment and drug-delivery devices |
WO2013071439A1 (en) * | 2011-11-16 | 2013-05-23 | The Royal Institution For The Advancement Of Learning / Mcgill University | Device, use thereof and method for reducing scarring of wound |
EP2931356B1 (en) | 2012-12-14 | 2019-03-06 | Mindera Corporation | Methods and devices for detection and acquisition of biomarkers |
ES2743404T3 (en) | 2012-12-21 | 2020-02-19 | Corium Inc | Matrix for therapeutic agent supply and manufacturing method |
EP2968887B1 (en) | 2013-03-12 | 2022-05-04 | Corium, Inc. | Microprojection applicators |
CA2903459C (en) | 2013-03-15 | 2024-02-20 | Corium International, Inc. | Multiple impact microprojection applicators and methods of use |
AU2014237279B2 (en) | 2013-03-15 | 2018-11-22 | Corium Pharma Solutions, Inc. | Microarray with polymer-free microstructures, methods of making, and methods of use |
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US10194935B2 (en) * | 2013-12-31 | 2019-02-05 | L'oreal | Shear-induced dermal infusion |
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US3964482A (en) | 1971-05-17 | 1976-06-22 | Alza Corporation | Drug delivery device |
BE795384A (en) | 1972-02-14 | 1973-08-13 | Ici Ltd | DRESSINGS |
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ATE462468T1 (en) * | 1999-06-04 | 2010-04-15 | Georgia Tech Res Inst | DEVICES FOR ENLARGED MICRONEEDLES PENETRATION IN BIOLOGICAL SKIN LAYERS |
US6743211B1 (en) * | 1999-11-23 | 2004-06-01 | Georgia Tech Research Corporation | Devices and methods for enhanced microneedle penetration of biological barriers |
US6537242B1 (en) * | 2000-06-06 | 2003-03-25 | Becton, Dickinson And Company | Method and apparatus for enhancing penetration of a member for the intradermal sampling or administration of a substance |
-
2000
- 2000-12-07 DE DE60020159T patent/DE60020159T2/en not_active Expired - Lifetime
- 2000-12-07 ES ES00984209T patent/ES2238333T3/en not_active Expired - Lifetime
- 2000-12-07 JP JP2001543208A patent/JP4312407B2/en not_active Expired - Fee Related
- 2000-12-07 PT PT00984209T patent/PT1239917E/en unknown
- 2000-12-07 EP EP00984209A patent/EP1239917B1/en not_active Expired - Lifetime
- 2000-12-07 HU HU0204002A patent/HU225467B1/en not_active IP Right Cessation
- 2000-12-07 CA CA002393537A patent/CA2393537C/en not_active Expired - Fee Related
- 2000-12-07 KR KR1020027007426A patent/KR100832754B1/en not_active IP Right Cessation
- 2000-12-07 WO PCT/US2000/033582 patent/WO2001041864A1/en active IP Right Grant
- 2000-12-07 IL IL15009100A patent/IL150091A0/en unknown
- 2000-12-07 AT AT00984209T patent/ATE295200T1/en not_active IP Right Cessation
- 2000-12-07 MX MXPA02005765A patent/MXPA02005765A/en active IP Right Grant
- 2000-12-07 CN CNB008183090A patent/CN100402106C/en not_active Expired - Fee Related
- 2000-12-07 DK DK00984209T patent/DK1239917T3/en active
- 2000-12-07 AU AU20870/01A patent/AU782610B2/en not_active Ceased
- 2000-12-08 US US09/733,305 patent/US20020111600A1/en not_active Abandoned
-
2002
- 2002-06-07 ZA ZA200204597A patent/ZA200204597B/en unknown
- 2002-06-07 NO NO20022721A patent/NO323128B1/en unknown
-
2003
- 2003-02-10 HK HK03100953.2A patent/HK1048773B/en not_active IP Right Cessation
-
2004
- 2004-03-05 US US10/794,637 patent/US20040181203A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
AU2087001A (en) | 2001-06-18 |
EP1239917A1 (en) | 2002-09-18 |
IL150091A0 (en) | 2002-12-01 |
US20020111600A1 (en) | 2002-08-15 |
WO2001041864A1 (en) | 2001-06-14 |
HK1048773B (en) | 2005-10-14 |
HK1048773A1 (en) | 2003-04-17 |
HUP0204002A2 (en) | 2003-03-28 |
NO20022721D0 (en) | 2002-06-07 |
AU782610B2 (en) | 2005-08-11 |
ES2238333T3 (en) | 2005-09-01 |
CA2393537C (en) | 2009-02-03 |
CN100402106C (en) | 2008-07-16 |
MXPA02005765A (en) | 2003-01-28 |
KR20020060996A (en) | 2002-07-19 |
KR100832754B1 (en) | 2008-05-27 |
HU225467B1 (en) | 2006-12-28 |
JP2003516205A (en) | 2003-05-13 |
PT1239917E (en) | 2005-08-31 |
CN1423571A (en) | 2003-06-11 |
JP4312407B2 (en) | 2009-08-12 |
NO323128B1 (en) | 2007-01-08 |
ATE295200T1 (en) | 2005-05-15 |
EP1239917B1 (en) | 2005-05-11 |
ZA200204597B (en) | 2004-09-29 |
DE60020159T2 (en) | 2005-10-06 |
NO20022721L (en) | 2002-08-07 |
DE60020159D1 (en) | 2005-06-16 |
DK1239917T3 (en) | 2005-08-22 |
US20040181203A1 (en) | 2004-09-16 |
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