CA2401098A1 - Treatment of obesity by bilateral vagus nerve stimulation - Google Patents
Treatment of obesity by bilateral vagus nerve stimulation Download PDFInfo
- Publication number
- CA2401098A1 CA2401098A1 CA002401098A CA2401098A CA2401098A1 CA 2401098 A1 CA2401098 A1 CA 2401098A1 CA 002401098 A CA002401098 A CA 002401098A CA 2401098 A CA2401098 A CA 2401098A CA 2401098 A1 CA2401098 A1 CA 2401098A1
- Authority
- CA
- Canada
- Prior art keywords
- electrical signal
- vagi
- stimulating
- pulses
- patient
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/36007—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation of urogenital or gastrointestinal organs, e.g. for incontinence control
Abstract
A method of treating patients for compulsive overeating includes stimulating left and right branches of the patient's vagus nerve simultaneously with electrical pulses in a predetermined sequence of a first period in which pulses are applied continuously, alternating with a second period in which n o pulses are applied. The electrical pulses are preferably applied to the vagu s nerve at a supradiaphragmatic location.
Claims (38)
1. A method of treating patients for obesity, which comprises the steps of:
performing bilateral stimulation of the patient's vagus nerve by applying a stimulating electrical signal to the right and left vagi, wherein the parameters of said signal are predetermined to produce a sensation of satiety in the patient.
performing bilateral stimulation of the patient's vagus nerve by applying a stimulating electrical signal to the right and left vagi, wherein the parameters of said signal are predetermined to produce a sensation of satiety in the patient.
2. The method of claim 1, including the step of applying said stimulating electrical signal intermittently to the right and left vagi.
3. The method of claim 2, wherein said intermittent application of said stimulating electrical signal is chronic.
4. The method of claim 1, including the step of applying said stimulating electrical signal continuously to the right and left vagi.
5. The method of claim 1, including the step of applying said stimulating electrical signal to the right and left vagi during a customary mealtime according to the patient's circadian cycle.
6. The method of claim 1, including the step of applying said stimulating electrical signal to the right and left vagi upon delivery of an external commencement signal administered by the patient.
7. The method of claim 1, including the step of applying the same stimulating electrical signal to both the right and left vagi.
8. The method of claim 1, including the step of applying a different stimulating electrical signal to the right vagus from the stimulating electrical signal applied to the left vagus.
9. The method of claim 1, including using separate nerve stimulator generators for stimulating the left and right vagi.
10. The method of claim 9, including implanting said separate nerve stimulator generators into the patient.
11. The method of claim 1, including implanting nerve stimulator generator apparatus into the patient for said bilateral stimulation of the vagi.
12. The method of claim 1, including the step of applying said stimulating electrical signal supra diaphragmatically to the left and right vagi.
13. The method of claim 1, wherein said stimulating electrical signal is characterized by a current magnitude below a predetermined retching level.
14. The method of claim 1, wherein said stimulating electrical signal is a pulse signal having a prescribed on-off duty cycle.
15. The method of claim 14, including the step of applying said stimulating electrical signal continuously to the right and left vagi so that pulses are applied during the on portion of said duty cycle and not during the off portion of said duty cycle.
16. The method of claim 15, including using separate nerve stimulator generators for stimulating the left and right vagi.
17. The method of claim 15, including implanting separate nerve stimulator generators into the patient to stimulate the left and right vagi.
18. The method of claim 15, including the step of applying said stimulating electrical signal supra diaphragmatically to the left and right vagi.
19. The method of claim 15, wherein one of said parameters of said stimulating electrical signal is a pulse current magnitude below a predetermined level at which the signal tends to produce retching in the patient.
20. The method of claim 15, wherein said pulse signal has a pulse current magnitude in a range up to about 6 ma.
21. The method of claim 20, wherein said pulse signal has a pulse width in a range up to about 500 ms.
22. The method of claim 21, wherein said pulse signal has a repetition frequency of about 30 Hz.
23. The method of claim 22, wherein said pulse signal has a duty cycle with a ratio of on to off of about 1:1.8.
24. A method of treating patients for compulsive overeating, which comprises the steps of:
stimulating left and right branches of the patient's vagus nerve simultaneously with electrical pulses in a predetermined sequence of a first period in which pulses are applied continuously, alternating with a second period in which no pulses are applied.
stimulating left and right branches of the patient's vagus nerve simultaneously with electrical pulses in a predetermined sequence of a first period in which pulses are applied continuously, alternating with a second period in which no pulses are applied.
25. The method of claim 24, including the step of applying said electrical pulses to the vagus nerve at a supradiaphragmatic location.
26. The method of claim 25, wherein said pulses have an electrical current magnitude not exceeding about 6 ma.
27. The method of claim 26, wherein said electrical current magnitude is preselected to be less than a level that induces retching in the patient.
28. The method of claim 27, wherein said pulses have a width not exceeding about 500 ms.
29. The method of claim 28, wherein said pulses have a repetition frequency of about 30 Hz.
30. The method of claim 29, wherein said second period is 1.8 times as long as said first period.
31. Apparatus for treating patients suffering from compulsive eating disorder, comprising:
implantable neurostimulator device means for simultaneously stimulating left and right branches of the patient's vagus nerve with electrical pulses in a predetermined sequence of a first period in which pulses are applied continuously, alternating with a second period in which no pulses are applied; and electrode means for implantation on said right and left branches in a supradiaphragmatic position.
implantable neurostimulator device means for simultaneously stimulating left and right branches of the patient's vagus nerve with electrical pulses in a predetermined sequence of a first period in which pulses are applied continuously, alternating with a second period in which no pulses are applied; and electrode means for implantation on said right and left branches in a supradiaphragmatic position.
32. The apparatus of claim 31, wherein said neurostimulator device means generates pulses with an adjustable electrical current magnitude not exceeding about 6 ma.
33. The apparatus of claim 32, wherein said neurostimulator device means generates pulses having an adjustable width not exceeding about 500 ms.
34. The apparatus of claim 33, wherein said neurostimulator device means generates pulses at a repetition frequency of about 30 Hz.
35. The method of claim 34, wherein said second period is adjusted to be 1.8 times as long as said first period.
36. The method of claim 1, wherein said electrical signal is applied synchronously to the right and left vagi.
37. The method of claim 1, wherein said electrical signal is applied asynchronously to the right and left vagi.
38. The method of claim 1, wherein said electrical signal is applied to the right and left vagi indirectly by stimulating the stomach or other visceral organ
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/US2000/040301 WO2002004068A1 (en) | 2000-07-06 | 2000-07-06 | Treatment of obesity by bilateral vagus nerve stimulation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2401098A1 true CA2401098A1 (en) | 2002-01-17 |
| CA2401098C CA2401098C (en) | 2012-03-13 |
Family
ID=21742130
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2401098A Expired - Lifetime CA2401098C (en) | 2000-07-06 | 2000-07-06 | Treatment of obesity by bilateral vagus nerve stimulation |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP1296743A1 (en) |
| JP (1) | JP2004502506A (en) |
| AU (1) | AU782785B2 (en) |
| CA (1) | CA2401098C (en) |
| WO (1) | WO2002004068A1 (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7908000B2 (en) | 2004-02-20 | 2011-03-15 | Brainsgate Ltd. | Transmucosal electrical stimulation |
| US9675796B2 (en) | 2013-11-10 | 2017-06-13 | Brainsgate Ltd. | Implant and delivery system for neural stimulator |
| US10271907B2 (en) | 2015-05-13 | 2019-04-30 | Brainsgate Ltd. | Implant and delivery system for neural stimulator |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6609025B2 (en) * | 2001-01-02 | 2003-08-19 | Cyberonics, Inc. | Treatment of obesity by bilateral sub-diaphragmatic nerve stimulation |
| US6754536B2 (en) | 2001-01-31 | 2004-06-22 | Medtronic, Inc | Implantable medical device affixed internally within the gastrointestinal tract |
| US7167751B1 (en) | 2001-03-01 | 2007-01-23 | Advanced Bionics Corporation | Method of using a fully implantable miniature neurostimulator for vagus nerve stimulation |
| US7239912B2 (en) | 2002-03-22 | 2007-07-03 | Leptos Biomedical, Inc. | Electric modulation of sympathetic nervous system |
| US7937145B2 (en) | 2002-03-22 | 2011-05-03 | Advanced Neuromodulation Systems, Inc. | Dynamic nerve stimulation employing frequency modulation |
| US7689276B2 (en) | 2002-09-13 | 2010-03-30 | Leptos Biomedical, Inc. | Dynamic nerve stimulation for treatment of disorders |
| US7236822B2 (en) | 2002-03-22 | 2007-06-26 | Leptos Biomedical, Inc. | Wireless electric modulation of sympathetic nervous system |
| US7689277B2 (en) | 2002-03-22 | 2010-03-30 | Leptos Biomedical, Inc. | Neural stimulation for treatment of metabolic syndrome and type 2 diabetes |
| US7702386B2 (en) | 2002-03-22 | 2010-04-20 | Leptos Biomedical, Inc. | Nerve stimulation for treatment of obesity, metabolic syndrome, and Type 2 diabetes |
| US7551964B2 (en) | 2002-03-22 | 2009-06-23 | Leptos Biomedical, Inc. | Splanchnic nerve stimulation for treatment of obesity |
| US20080077192A1 (en) | 2002-05-03 | 2008-03-27 | Afferent Corporation | System and method for neuro-stimulation |
| US8064994B2 (en) | 2003-01-14 | 2011-11-22 | The United States Of America As Represented By The Department Of Veterans Affairs | Cervical vagal stimulation induced weight loss |
| US9254388B2 (en) | 2003-07-10 | 2016-02-09 | Codes Of Life, Llc | Method and system for regulation of endocrine and exocrine glands by means of neuro-electrical coded signals |
| US7725176B2 (en) | 2003-07-10 | 2010-05-25 | Schuler Eleanor L | Method and system for regulation of endocrine and exocrine glands by means of neuro-electrical coded signals |
| US8055347B2 (en) | 2005-08-19 | 2011-11-08 | Brainsgate Ltd. | Stimulation for treating brain events and other conditions |
| US9233245B2 (en) | 2004-02-20 | 2016-01-12 | Brainsgate Ltd. | SPG stimulation |
| US7623924B2 (en) | 2004-08-31 | 2009-11-24 | Leptos Biomedical, Inc. | Devices and methods for gynecologic hormone modulation in mammals |
| US8295926B2 (en) | 2006-06-02 | 2012-10-23 | Advanced Neuromodulation Systems, Inc. | Dynamic nerve stimulation in combination with other eating disorder treatment modalities |
| US8321030B2 (en) | 2009-04-20 | 2012-11-27 | Advanced Neuromodulation Systems, Inc. | Esophageal activity modulated obesity therapy |
| US11154238B2 (en) | 2015-08-07 | 2021-10-26 | Electroceuticals, Llc | Systems, methods and apparatuses for providing bioelectronic neurocode-based therapies to mammals |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5035437A (en) | 1989-11-13 | 1991-07-30 | Outboard Marine Corporation | Outboard motor carrier |
| US5263480A (en) * | 1991-02-01 | 1993-11-23 | Cyberonics, Inc. | Treatment of eating disorders by nerve stimulation |
| US5188104A (en) * | 1991-02-01 | 1993-02-23 | Cyberonics, Inc. | Treatment of eating disorders by nerve stimulation |
| US5330507A (en) * | 1992-04-24 | 1994-07-19 | Medtronic, Inc. | Implantable electrical vagal stimulation for prevention or interruption of life threatening arrhythmias |
| US5540730A (en) * | 1995-06-06 | 1996-07-30 | Cyberonics, Inc. | Treatment of motility disorders by nerve stimulation |
-
2000
- 2000-07-06 AU AU68028/00A patent/AU782785B2/en not_active Ceased
- 2000-07-06 EP EP00955908A patent/EP1296743A1/en not_active Withdrawn
- 2000-07-06 WO PCT/US2000/040301 patent/WO2002004068A1/en not_active Application Discontinuation
- 2000-07-06 CA CA2401098A patent/CA2401098C/en not_active Expired - Lifetime
- 2000-07-06 JP JP2002508519A patent/JP2004502506A/en active Pending
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7908000B2 (en) | 2004-02-20 | 2011-03-15 | Brainsgate Ltd. | Transmucosal electrical stimulation |
| US8010189B2 (en) | 2004-02-20 | 2011-08-30 | Brainsgate Ltd. | SPG stimulation for treating complications of subarachnoid hemorrhage |
| US8954149B2 (en) | 2004-02-20 | 2015-02-10 | Brainsgate Ltd. | External stimulation of the SPG |
| US9675796B2 (en) | 2013-11-10 | 2017-06-13 | Brainsgate Ltd. | Implant and delivery system for neural stimulator |
| US10512771B2 (en) | 2013-11-10 | 2019-12-24 | Brainsgate Ltd. | Implant and delivery system for neural stimulator |
| US10271907B2 (en) | 2015-05-13 | 2019-04-30 | Brainsgate Ltd. | Implant and delivery system for neural stimulator |
Also Published As
| Publication number | Publication date |
|---|---|
| AU6802800A (en) | 2002-01-21 |
| WO2002004068A1 (en) | 2002-01-17 |
| JP2004502506A (en) | 2004-01-29 |
| AU782785B2 (en) | 2005-08-25 |
| CA2401098C (en) | 2012-03-13 |
| EP1296743A1 (en) | 2003-04-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKEX | Expiry |
Effective date: 20200706 |