CA2446741A1 - Ophthalmic drug delivery device - Google Patents

Ophthalmic drug delivery device Download PDF

Info

Publication number
CA2446741A1
CA2446741A1 CA002446741A CA2446741A CA2446741A1 CA 2446741 A1 CA2446741 A1 CA 2446741A1 CA 002446741 A CA002446741 A CA 002446741A CA 2446741 A CA2446741 A CA 2446741A CA 2446741 A1 CA2446741 A1 CA 2446741A1
Authority
CA
Canada
Prior art keywords
drug delivery
delivery device
ophthalmic drug
fluid
injection port
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002446741A
Other languages
French (fr)
Other versions
CA2446741C (en
Inventor
Yoseph Yaacobi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alcon Inc
Original Assignee
Alcon, Inc.
Yoseph Yaacobi
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alcon, Inc., Yoseph Yaacobi filed Critical Alcon, Inc.
Publication of CA2446741A1 publication Critical patent/CA2446741A1/en
Application granted granted Critical
Publication of CA2446741C publication Critical patent/CA2446741C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/0008Introducing ophthalmic products into the ocular cavity or retaining products therein
    • A61F9/0017Introducing ophthalmic products into the ocular cavity or retaining products therein implantable in, or in contact with, the eye, e.g. ocular inserts
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/16Antivirals for RNA viruses for influenza or rhinoviruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/20Surgical instruments, devices or methods, e.g. tourniquets for vaccinating or cleaning the skin previous to the vaccination
    • A61B17/205Vaccinating by means of needles or other puncturing devices
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0058Additional features; Implant or prostheses properties not otherwise provided for
    • A61F2250/0067Means for introducing or releasing pharmaceutical products into the body
    • A61F2250/0068Means for introducing or releasing pharmaceutical products into the body the pharmaceutical product being in a reservoir
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0048Eye, e.g. artificial tears
    • A61K9/0051Ocular inserts, ocular implants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin

Abstract

An ophthalmic drug delivery device having a scleral surface, an orbital surface, an injection port on the orbital surface, and a fluid conducting passageway disposed within the device that is fluidily coupled to the injection port and has an opening for communicating the fluid to an outer surface of the sclera is disclosed. The fluid contains a pharmaceutically active agent useful for the treatment of a disease of the posterior segment of the eye.
CA002446741A 2001-07-23 2002-07-22 Ophthalmic drug delivery device Expired - Fee Related CA2446741C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US30722601P 2001-07-23 2001-07-23
US60/307,226 2001-07-23
PCT/US2002/023116 WO2003009784A1 (en) 2001-07-23 2002-07-22 Ophthalmic drug delivery device

Publications (2)

Publication Number Publication Date
CA2446741A1 true CA2446741A1 (en) 2003-02-06
CA2446741C CA2446741C (en) 2009-09-29

Family

ID=23188800

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002446741A Expired - Fee Related CA2446741C (en) 2001-07-23 2002-07-22 Ophthalmic drug delivery device

Country Status (17)

Country Link
US (1) US6986900B2 (en)
EP (1) EP1385452B1 (en)
JP (1) JP4249611B2 (en)
CN (1) CN100349562C (en)
AT (1) ATE339170T1 (en)
AU (1) AU2002319606B2 (en)
BR (1) BR0210287A (en)
CA (1) CA2446741C (en)
CY (1) CY1105762T1 (en)
DE (1) DE60214697T2 (en)
DK (1) DK1385452T3 (en)
ES (1) ES2271301T3 (en)
MX (1) MXPA03011610A (en)
PL (1) PL204645B1 (en)
PT (1) PT1385452E (en)
WO (1) WO2003009784A1 (en)
ZA (1) ZA200308811B (en)

Families Citing this family (66)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2358296A1 (en) * 1999-01-05 2000-07-13 Anthony P. Adamis Targeted transscleral controlled release drug delivery to the retina and choroid
US7431710B2 (en) 2002-04-08 2008-10-07 Glaukos Corporation Ocular implants with anchors and methods thereof
EP2316394B1 (en) 2001-06-12 2016-11-23 The Johns Hopkins University Reservoir device for intraocular drug delivery
DK1385452T3 (en) * 2001-07-23 2007-01-15 Alcon Inc Device for administering an ophthalmic drug
WO2003092665A2 (en) * 2002-05-02 2003-11-13 Massachusetts Eye And Ear Infirmary Ocular drug delivery systems and use thereof
WO2004073551A2 (en) * 2003-02-18 2004-09-02 Massachusetts Eye And Ear Infirmary Transscleral drug delivery device and related methods
CA2536454C (en) 2003-08-26 2013-03-26 Vista Scientific Ocular drug delivery device
US20050244500A1 (en) * 2004-04-30 2005-11-03 Allergan, Inc. Intravitreal implants in conjuction with photodynamic therapy to improve vision
US20060233858A1 (en) * 2005-03-08 2006-10-19 Allergan, Inc. Systems and methods providing targeted intraocular drug delivery
US20070212397A1 (en) * 2005-09-15 2007-09-13 Roth Daniel B Pharmaceutical delivery device and method for providing ocular treatment
MX2008010126A (en) 2006-02-08 2010-02-22 Tyrx Pharma Inc Temporarily stiffened mesh prostheses.
DK2004172T3 (en) * 2006-03-31 2019-04-23 Mati Therapeutics Inc PHARMACEUTICAL ADMINISTRATION STRUCTURES AND COMPOSITIONS FOR NASOLACRIMAL SYSTEM
US20070282262A1 (en) * 2006-05-19 2007-12-06 Alcon, Inc. Surgical system having integral pneumatic manifolds
US9474645B2 (en) * 2006-06-21 2016-10-25 Johnson & Johnson Vision Care, Inc. Punctal plugs for the delivery of active agents
CN101505694B (en) * 2006-06-21 2012-02-22 庄臣及庄臣视力保护公司 Punctal plugs for the delivery of active agents
US8911496B2 (en) 2006-07-11 2014-12-16 Refocus Group, Inc. Scleral prosthesis for treating presbyopia and other eye disorders and related devices and methods
DE102007024642A1 (en) 2007-05-24 2008-11-27 Eyesense Ag Hydrogel implant for sensor of metabolites on the eye
US9308124B2 (en) 2007-12-20 2016-04-12 University Of Southern California Apparatus and methods for delivering therapeutic agents
US20090192493A1 (en) * 2008-01-03 2009-07-30 University Of Southern California Implantable drug-delivery devices, and apparatus and methods for refilling the devices
CN102202706A (en) 2008-05-08 2011-09-28 迷你泵有限责任公司 Implantable drug-delivery devices, and apparatus and methods for filling the devices
ES2747755T3 (en) 2009-01-29 2020-03-11 Forsight Vision4 Inc Administration of a drug to the posterior segment
US8623395B2 (en) 2010-01-29 2014-01-07 Forsight Vision4, Inc. Implantable therapeutic device
WO2010093945A2 (en) * 2009-02-13 2010-08-19 Glaukos Corporation Uveoscleral drug delivery implant and methods for implanting the same
US10206813B2 (en) 2009-05-18 2019-02-19 Dose Medical Corporation Implants with controlled drug delivery features and methods of using same
CN102596097B (en) 2009-06-03 2015-05-20 弗赛特实验室有限责任公司 Anterior segment drug delivery
US20110105990A1 (en) * 2009-11-04 2011-05-05 Silvestrini Thomas A Zonal drug delivery device and method
US8529492B2 (en) 2009-12-23 2013-09-10 Trascend Medical, Inc. Drug delivery devices and methods
CN103209664A (en) 2010-08-05 2013-07-17 弗赛特影像4股份有限公司 Implantable therapeutic device
SI2600930T1 (en) 2010-08-05 2021-08-31 Forsight Vision4, Inc. Injector apparatus for drug delivery
EP2600876B1 (en) 2010-08-05 2015-04-29 Forsight Vision4, Inc. Combined drug delivery methods and apparatus
AU2011329656B2 (en) 2010-11-19 2017-01-05 Forsight Vision4, Inc. Therapeutic agent formulations for implanted devices
US9603997B2 (en) 2011-03-14 2017-03-28 Minipumps, Llc Implantable drug pumps and refill devices therefor
US9919099B2 (en) 2011-03-14 2018-03-20 Minipumps, Llc Implantable drug pumps and refill devices therefor
US10286146B2 (en) 2011-03-14 2019-05-14 Minipumps, Llc Implantable drug pumps and refill devices therefor
US10245178B1 (en) 2011-06-07 2019-04-02 Glaukos Corporation Anterior chamber drug-eluting ocular implant
EP2726016B1 (en) 2011-06-28 2023-07-19 ForSight Vision4, Inc. An apparatus for collecting a sample of fluid from a reservoir chamber of a therapeutic device for the eye
EP2739252A4 (en) 2011-08-05 2015-08-12 Forsight Vision4 Inc Small molecule delivery with implantable therapeutic device
WO2013040238A2 (en) 2011-09-13 2013-03-21 Vista Scientific Llc Sustained release ocular drug delivery devices and methods of manufacture
KR102071083B1 (en) 2011-09-14 2020-01-29 포사이트 비젼5, 인크. Ocular insert apparatus and methods
PT2755600T (en) 2011-09-16 2021-04-19 Forsight Vision4 Inc Fluid exchange apparatus and methods
WO2013116061A1 (en) 2012-02-03 2013-08-08 Forsight Vision4, Inc. Insertion and removal methods and apparatus for therapeutic devices
US8900300B1 (en) 2012-02-22 2014-12-02 Omega Ophthalmics Llc Prosthetic capsular bag and method of inserting the same
EP2830552A4 (en) * 2012-03-27 2015-11-25 Univ Duke Ophthalmic drug delivery device and methods of use
EP2903572B1 (en) 2012-10-08 2019-05-15 Universität Leipzig A device for a medical treatment of a sclera
CN104884006B (en) 2012-10-26 2017-12-15 弗赛特影像5股份有限公司 Ophthalmic system for sustained release drugs to eyes
CA2905496A1 (en) 2013-03-14 2014-09-25 Forsight Vision4, Inc. Systems for sustained intraocular delivery of low solubility compounds from a port delivery system implant
JP6385423B2 (en) 2013-03-28 2018-09-05 フォーサイト・ビジョン フォー・インコーポレーテッド Ocular graft for therapeutic substance delivery
WO2015184173A1 (en) 2014-05-29 2015-12-03 Dose Medical Corporation Implants with controlled drug delivery features and methods of using same
EP4029474A1 (en) 2014-06-19 2022-07-20 Omega Ophthalmics LLC Prosthetic capsular devices
CN106687079B (en) 2014-07-15 2019-10-11 弗赛特影像4股份有限公司 Eyes are implanted into conveying device and method
MY182793A (en) 2014-08-08 2021-02-05 Forsight Vision4 Inc Stable and soluble formulations of receptor tyrosine kinase inhibitors, and methods of preparation thereof
SG11201703726XA (en) 2014-11-10 2017-06-29 Forsight Vision4 Inc Expandable drug delivery devices and method of use
US9358103B1 (en) 2015-02-10 2016-06-07 Omega Ophthalmics Llc Prosthetic capsular devices, systems, and methods
US20160296532A1 (en) 2015-04-13 2016-10-13 Forsight Vision5, Inc. Ocular Insert Composition of a Semi-Crystalline or Crystalline Pharmaceutically Active Agent
WO2016187426A1 (en) 2015-05-19 2016-11-24 Amorphex Therapeutics Llc A device that delivers a sustained low-dose of a myopia-suppressing drug
US11925578B2 (en) 2015-09-02 2024-03-12 Glaukos Corporation Drug delivery implants with bi-directional delivery capacity
US11564833B2 (en) 2015-09-25 2023-01-31 Glaukos Corporation Punctal implants with controlled drug delivery features and methods of using same
KR20180084104A (en) 2015-11-20 2018-07-24 포사이트 비젼4, 인크. Porous structures for extended release drug delivery devices
WO2017176886A1 (en) 2016-04-05 2017-10-12 Forsight Vision4, Inc. Implantable ocular drug delivery devices
CN109937025B (en) 2016-04-20 2022-07-29 多斯医学公司 Delivery device for bioabsorbable ocular drugs
CA3026494C (en) 2016-06-06 2022-06-07 Omega Ophthalmics Llc Prosthetic capsular devices, systems, and methods
AU2017345731B2 (en) 2016-10-21 2019-10-24 Omega Ophthalmics Llc Prosthetic capsular devices, systems, and methods
WO2018143481A1 (en) * 2017-02-01 2018-08-09 国立大学法人東北大学 Sustained drug release device that can be reinjected with the drug, and injectable gel for refilling
CN111655206B (en) 2017-11-21 2022-10-14 弗赛特影像4股份有限公司 Fluid exchange device for expandable port delivery system and method of use
EP3773334A4 (en) 2018-04-06 2021-12-29 Omega Ophthalmics LLC Prosthetic capsular devices, systems, and methods
AU2021359888A1 (en) 2020-10-12 2023-06-15 Omega Ophthalmics Llc Prosthetic capsular devices, systems, and methods

Family Cites Families (65)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US188282A (en) * 1877-03-13 Improvement in beer-coolers
US175324A (en) * 1876-03-28 Improvement in automatic gates
US3416530A (en) * 1966-03-02 1968-12-17 Richard A. Ness Eyeball medication dispensing tablet
US3828777A (en) * 1971-11-08 1974-08-13 Alza Corp Microporous ocular device
US4014335A (en) * 1975-04-21 1977-03-29 Alza Corporation Ocular drug delivery device
US4300557A (en) * 1980-01-07 1981-11-17 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Method for treating intraocular malignancies
US4327725A (en) * 1980-11-25 1982-05-04 Alza Corporation Osmotic device with hydrogel driving member
US4624848A (en) * 1984-05-10 1986-11-25 Ciba-Geigy Corporation Active agent containing hydrogel devices wherein the active agent concentration profile contains a sigmoidal concentration gradient for improved constant release, their manufacture and use
US5147647A (en) * 1986-10-02 1992-09-15 Sohrab Darougar Ocular insert for the fornix
US5322691A (en) * 1986-10-02 1994-06-21 Sohrab Darougar Ocular insert with anchoring protrusions
US4853224A (en) * 1987-12-22 1989-08-01 Visionex Biodegradable ocular implants
US4997652A (en) * 1987-12-22 1991-03-05 Visionex Biodegradable ocular implants
DE3905050A1 (en) * 1989-02-18 1990-08-30 Lohmann Therapie Syst Lts THERAPEUTIC SYSTEM FOR DELAYED AND CONTROLLED TRANSDERMAL OR TRANSMUCOSAL ADMINISTRATION OF ACTIVE SUBSTANCES (II)
US4946450A (en) * 1989-04-18 1990-08-07 Biosource Genetics Corporation Glucan/collagen therapeutic eye shields
US5164188A (en) * 1989-11-22 1992-11-17 Visionex, Inc. Biodegradable ocular implants
DE4022553A1 (en) 1990-07-16 1992-01-23 Hund Helmut Gmbh Medical contact lens - with recess contg. therapeutically or diagnostically active substance
US5290892A (en) * 1990-11-07 1994-03-01 Nestle S.A. Flexible intraocular lenses made from high refractive index polymers
US5378475A (en) * 1991-02-21 1995-01-03 University Of Kentucky Research Foundation Sustained release drug delivery devices
US5679666A (en) * 1991-11-22 1997-10-21 Alcon Laboratories, Inc. Prevention and treatment of ocular neovascularization by treatment with angiostatic steroids
US5770592A (en) * 1991-11-22 1998-06-23 Alcon Laboratories, Inc. Prevention and treatment of ocular neovascularization using angiostatic steroids
US5178635A (en) * 1992-05-04 1993-01-12 Allergan, Inc. Method for determining amount of medication in an implantable device
FR2690846B1 (en) * 1992-05-05 1995-07-07 Aiache Jean Marc GALENIC FORM FOR EYE ADMINISTRATION AND METHOD OF PREPARATION.
AU5092493A (en) 1992-09-08 1994-03-29 Allergan, Inc. Sustained release of ophthalmic drugs from a soluble polymer drug delivery vehicle
WO1995003009A1 (en) * 1993-07-22 1995-02-02 Oculex Pharmaceuticals, Inc. Method of treatment of macular degeneration
US5443505A (en) * 1993-11-15 1995-08-22 Oculex Pharmaceuticals, Inc. Biocompatible ocular implants
US5516522A (en) * 1994-03-14 1996-05-14 Board Of Supervisors Of Louisiana State University Biodegradable porous device for long-term drug delivery with constant rate release and method of making the same
CA2185699A1 (en) 1994-04-04 1995-10-12 William R. Freeman Use of phosphonylmethoxyalkyl nucleosides for the treatment of raised intraocular pressure
US5466233A (en) 1994-04-25 1995-11-14 Escalon Ophthalmics, Inc. Tack for intraocular drug delivery and method for inserting and removing same
US5710165A (en) * 1994-07-06 1998-01-20 Synthelabo Use of polyamine antagonists for the treatment of glaucoma
AUPM897594A0 (en) * 1994-10-25 1994-11-17 Daratech Pty Ltd Controlled release container
DK0788351T3 (en) * 1994-11-10 2003-05-26 Univ Kentucky Res Found Implantable, refillable device for speed-controlled drug delivery directly to an internal part of the body
US5725493A (en) * 1994-12-12 1998-03-10 Avery; Robert Logan Intravitreal medicine delivery
US5972326A (en) * 1995-04-18 1999-10-26 Galin; Miles A. Controlled release of pharmaceuticals in the anterior chamber of the eye
ES2225886T3 (en) 1995-05-14 2005-03-16 Optonol Ltd. INTRAOCULAR IMPLANT, TRANSFER DEVICE AND IMPLEMENTATION METHOD.
US5773019A (en) * 1995-09-27 1998-06-30 The University Of Kentucky Research Foundation Implantable controlled release device to deliver drugs directly to an internal portion of the body
AUPN605795A0 (en) 1995-10-19 1995-11-09 F.H. Faulding & Co. Limited Analgesic pharmaceutical composition
US5824073A (en) * 1996-03-18 1998-10-20 Peyman; Gholam A. Macular indentor for use in the treatment of subretinal neovascular membranes
US5743274A (en) * 1996-03-18 1998-04-28 Peyman; Gholam A. Macular bandage for use in the treatment of subretinal neovascular members
US5904144A (en) * 1996-03-22 1999-05-18 Cytotherapeutics, Inc. Method for treating ophthalmic diseases
JP3309175B2 (en) 1996-03-25 2002-07-29 参天製薬株式会社 Scleral plug containing proteinaceous drug
US5797898A (en) * 1996-07-02 1998-08-25 Massachusetts Institute Of Technology Microchip drug delivery devices
US6120460A (en) * 1996-09-04 2000-09-19 Abreu; Marcio Marc Method and apparatus for signal acquisition, processing and transmission for evaluation of bodily functions
ZA9710342B (en) 1996-11-25 1998-06-10 Alza Corp Directional drug delivery stent and method of use.
ES2205462T3 (en) 1997-03-31 2004-05-01 Alza Corporation DUFUSION SUPPLY SYSTEM, IMPLANTABLE.
DE69827138T2 (en) * 1997-08-11 2006-02-23 Allergan, Inc., Irvine Sterile retinoid-containing biodegradable implant with improved biocompatibility and process for its preparation
US5902598A (en) * 1997-08-28 1999-05-11 Control Delivery Systems, Inc. Sustained release drug delivery devices
US6066671A (en) 1997-12-19 2000-05-23 Alcon Laboratories, Inc. Treatment of GLC1A glaucoma with 3-benzoyl-phenylacetic acids, esters, or amides
ATE365550T1 (en) 1998-03-13 2007-07-15 Univ Johns Hopkins Med USE OF A PROTEIN KINASE INHIBITOR SUCH AS GENISTEIN IN THE TREATMENT OF DIABETIC RETINOPATHY
US6378526B1 (en) * 1998-08-03 2002-04-30 Insite Vision, Incorporated Methods of ophthalmic administration
US6146366A (en) * 1998-11-03 2000-11-14 Ras Holding Corp Device for the treatment of macular degeneration and other eye disorders
US6399655B1 (en) 1998-12-22 2002-06-04 Johns Hopkins University, School Of Medicine Method for the prophylactic treatment of cataracts
US6217895B1 (en) 1999-03-22 2001-04-17 Control Delivery Systems Method for treating and/or preventing retinal diseases with sustained release corticosteroids
AU775149B2 (en) * 1999-10-21 2004-07-22 Alcon Inc. Sub-tenon drug delivery
EP1473003B1 (en) * 1999-10-21 2008-11-19 Alcon, Inc. Drug delivery device
US6416777B1 (en) * 1999-10-21 2002-07-09 Alcon Universal Ltd. Ophthalmic drug delivery device
RU2149615C1 (en) 1999-11-10 2000-05-27 Нестеров Аркадий Павлович Method for introducing drugs in treating posterior eye segment diseases
AUPQ496500A0 (en) 2000-01-06 2000-02-03 University Of Sydney, The Kit
HUP0301786A2 (en) * 2000-01-12 2003-10-28 Becton Dickinson Co Systems and methods for reducing intraocular pressure
US6375972B1 (en) * 2000-04-26 2002-04-23 Control Delivery Systems, Inc. Sustained release drug delivery devices, methods of use, and methods of manufacturing thereof
PT1313415E (en) * 2000-08-30 2008-11-25 Univ Johns Hopkins Devices for intraocular drug delivery
CA2433032C (en) * 2001-01-03 2008-11-25 Bausch & Lomb Incorporated Sustained release drug delivery devices with coated drug cores
US7181287B2 (en) 2001-02-13 2007-02-20 Second Sight Medical Products, Inc. Implantable drug delivery device
US6713081B2 (en) * 2001-03-15 2004-03-30 The United States Of America As Represented By The Department Of Health And Human Services Ocular therapeutic agent delivery devices and methods for making and using such devices
EP2316394B1 (en) 2001-06-12 2016-11-23 The Johns Hopkins University Reservoir device for intraocular drug delivery
DK1385452T3 (en) * 2001-07-23 2007-01-15 Alcon Inc Device for administering an ophthalmic drug

Also Published As

Publication number Publication date
ES2271301T3 (en) 2007-04-16
JP2004535886A (en) 2004-12-02
US6986900B2 (en) 2006-01-17
EP1385452A4 (en) 2006-01-18
AU2002319606B2 (en) 2006-09-14
CN100349562C (en) 2007-11-21
JP4249611B2 (en) 2009-04-02
PL369246A1 (en) 2005-04-18
BR0210287A (en) 2005-12-13
DE60214697T2 (en) 2007-09-13
ATE339170T1 (en) 2006-10-15
CY1105762T1 (en) 2011-02-02
ZA200308811B (en) 2004-11-23
DE60214697D1 (en) 2006-10-26
CA2446741C (en) 2009-09-29
WO2003009784A1 (en) 2003-02-06
PL204645B1 (en) 2010-01-29
EP1385452A1 (en) 2004-02-04
MXPA03011610A (en) 2004-07-01
US20040092911A1 (en) 2004-05-13
PT1385452E (en) 2006-12-29
DK1385452T3 (en) 2007-01-15
CN1630494A (en) 2005-06-22
EP1385452B1 (en) 2006-09-13

Similar Documents

Publication Publication Date Title
CA2446741A1 (en) Ophthalmic drug delivery device
CA2447802A1 (en) Ophthalmic drug delivery device
EP1473003A3 (en) Drug delivery device
WO2005020907A3 (en) Ocular drug delivery device
US5601548A (en) Open angle glaucoma treatment apparatus and method
WO2004073551A3 (en) Transscleral drug delivery device and related methods
WO2001041685A3 (en) Treatment of ocular disease
CA2433849A1 (en) Glaucoma treatment device and method
WO2002100318A3 (en) Reservoir device for intraocular drug delivery
WO2002089699A3 (en) Medical device and methods of use for glaucoma treatment
WO2000059420A1 (en) Improved conjunctival inserts for topical delivery of medication or lubrication
AR039130A2 (en) METHOD OF ADMINISTRATION OF A PHARMACEUTICALLY ACTIVE AGENT WITH A HUMAN EYE
ATE420624T1 (en) PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF EYE DISEASES
WO2003015667A8 (en) Method and intra sclera implant for treatment of glaucoma and presbyopia
CA2454976A1 (en) Therapeutic agent for glaucoma comprising compound having pi3 kinase inhibitory action as active ingredient
EP1754453A3 (en) Improved scleral prosthesis for treatment of presbyopia and other eye disorders
WO1998039293A3 (en) 13-thia prostaglandins for use in glaucoma therapy
WO2003028598A3 (en) An ophthalmic delivery device
CA2305892A1 (en) Lens arrangement for vitreoretinal surgery
CA2414586A1 (en) Agent for therapeutic treatment of optic nerve diseases and the like
MXPA03010363A (en) Method for treating ocular hypertension and glaucoma.
WO2003011299A3 (en) Treatment of ocular hypertension and glaucoma
Brogliatti et al. Comparison of the efficacy on intraocular pressure and retinal blood flow of a beta-blocker (timolol maleate) against the fixed association of a topical carbonic anhydrase (dorzolamide) and a beta-blocker (timolol maleate)
Goldberg Comparison of tropical travoprost eye drops given once daily and timolol 0.5% given twice daily in patients with open-angle glaucoma or ocular hypertension. J. Glaucoma 2001; 10: 414-22
RU2002109353A (en) Method for lymphotropic therapy of patients with open-angle glaucoma with normalized intraocular pressure

Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed

Effective date: 20180723