CA2447166A1 - Delivery of erectile dysfunction drugs through an inhalation route - Google Patents
Delivery of erectile dysfunction drugs through an inhalation route Download PDFInfo
- Publication number
- CA2447166A1 CA2447166A1 CA002447166A CA2447166A CA2447166A1 CA 2447166 A1 CA2447166 A1 CA 2447166A1 CA 002447166 A CA002447166 A CA 002447166A CA 2447166 A CA2447166 A CA 2447166A CA 2447166 A1 CA2447166 A1 CA 2447166A1
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- Prior art keywords
- aerosol
- sildenafil
- tadalafil
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- Prior art date
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F24—HEATING; RANGES; VENTILATING
- F24V—COLLECTION, PRODUCTION OR USE OF HEAT NOT OTHERWISE PROVIDED FOR
- F24V30/00—Apparatus or devices using heat produced by exothermal chemical reactions other than combustion
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
- A61M11/04—Sprayers or atomisers specially adapted for therapeutic purposes operated by the vapour pressure of the liquid to be sprayed or atomised
- A61M11/041—Sprayers or atomisers specially adapted for therapeutic purposes operated by the vapour pressure of the liquid to be sprayed or atomised using heaters
- A61M11/042—Sprayers or atomisers specially adapted for therapeutic purposes operated by the vapour pressure of the liquid to be sprayed or atomised using heaters electrical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/82—Internal energy supply devices
- A61M2205/8206—Internal energy supply devices battery-operated
Abstract
The present invention relates to the delivery of erectile dysfunction drugs through an inhalation route. Specifically, it relates to aerosols containing erectile dysfunction drugs that are used in inhalation therapy. In a composition aspect of the present invention, the aerosol comprises particles comprising at least 5 percent by weight of an erectile dysfunction drug. In a method aspect of the present invention, an erectile dysfunction drug is delivered to a mammal through an inhalation route. The method comprises: a) heating a composition, wherein the composition comprises at least 5 percent by weight of an erectile dysfunction drug, to form a vapor; and, b) allowing th e vapor to cool, thereby forming a condensation aerosol comprising particles, which is inhaled by the mammal. In a kit aspect of the present invention, a kit for delivering an erectile dysfunction drug through an inhalation route to a mammal is provided which comprises: a) a composition comprising at least 5 percent by weight of an erectile dysfunction drug; and, b) a device that for ms an erectile dysfunction drug aerosol from the composition, for inhalation by the mammal.
Claims (15)
1. An aerosol for inhalation therapy, wherein the aerosol comprises particles comprising at least 10 percent by weight of an erectile dysfunction drug, and wherein the erectile dysfunction drug is not sildenafil citrate.
2. An aerosol for inhalation therapy, wherein the aerosol comprises particles comprising at least 10 percent by weight of sildenafil, tadalafil or vardenafil.
3. The aerosol according to Claim 2, wherein the aerosol particles have a mass median aerodynamic diameter of less than 3 microns.
4. The aerosol according to Claim 2, wherein the particles comprise less than 5 percent by weight of sildenafil or tadalafil degradation products.
5. The aerosol according to Claim 2, wherein the aerosol comprises particles comprising at least 70 percent by weight of sildenafil, tadalafil or vardenafil.
6. The aerosol according to Claim 5, wherein the aerosol particles have a mass median aerodynamic diameter less than 2 microns.
7. The aerosol according to Claim 6, wherein the aerosol comprises particles comprising at least 95 percent by weight of sildenafil or tadalafil.
8. A method of delivering sildenafil, tadalafil or vardenafil to a mammal through an inhalation route, wherein the route comprises:
a) heating a composition, wherein the composition comprises at least 5 percent by weight of sildenafil, tadalafil or vardenafil, to form a vapor; and, b) allowing the vapor to cool, thereby forming a condensation aerosol comprising particles, which is inhaled by the mammal.
a) heating a composition, wherein the composition comprises at least 5 percent by weight of sildenafil, tadalafil or vardenafil, to form a vapor; and, b) allowing the vapor to cool, thereby forming a condensation aerosol comprising particles, which is inhaled by the mammal.
9. The method according to Claim 8, wherein the particles comprise at least 10 percent by weight of sildenafil, tadalafil or vardenafil.
10. The method according to Claim 8, wherein the aerosol particles have a mass median aerodynamic diameter of less than 3 microns.
11. The method according to Claim 8, wherein the particles comprise less than 5 percent by weight of sildenafil or tadalafil degradation products.
12. The method according to Claim 10, wherein the aerosol comprises particles comprising at least 70 percent by weight of sildenafil, tadalafil or vardenafil.
13. The method according to Claim 12, wherein the aerosol particles have a mass median aerodynamic diameter less than 2 microns.
14. The method according to Claim 13, wherein the aerosol comprises particles comprising at least 95 percent by weight of sildenafil or tadalafil.
15. A kit for delivering sildenafil, tadalafil or vardenafil through an inhalation route to a mammal, wherein the kit comprises:
a) a composition comprising at least 5 percent by weight of sildenafil, tadalafil or vardenafil; and, b) a device that forms a sildenafil, tadalafil or vardenafil aerosol from the composition, for inhalation by the mammal and wherein the device comprises:
a) an element for heating the sildenafil, tadalafil or vardenafil composition to form a vapor;
b) an element allowing the vapor to cool to form an aerosol; and, c) an element permitting the mammal to inhale the aerosol.
a) a composition comprising at least 5 percent by weight of sildenafil, tadalafil or vardenafil; and, b) a device that forms a sildenafil, tadalafil or vardenafil aerosol from the composition, for inhalation by the mammal and wherein the device comprises:
a) an element for heating the sildenafil, tadalafil or vardenafil composition to form a vapor;
b) an element allowing the vapor to cool to form an aerosol; and, c) an element permitting the mammal to inhale the aerosol.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
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US29420301P | 2001-05-24 | 2001-05-24 | |
US60/294,203 | 2001-05-24 | ||
US31747901P | 2001-09-05 | 2001-09-05 | |
US60/317,479 | 2001-09-05 | ||
PCT/US2002/016398 WO2002094219A2 (en) | 2001-05-24 | 2002-05-22 | Delivery of erectile dysfunction drugs through an inhalation route |
Publications (2)
Publication Number | Publication Date |
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CA2447166A1 true CA2447166A1 (en) | 2002-11-28 |
CA2447166C CA2447166C (en) | 2009-12-22 |
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Application Number | Title | Priority Date | Filing Date |
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CA002446904A Abandoned CA2446904A1 (en) | 2001-05-24 | 2002-05-13 | Delivery of drug esters through an inhalation route |
CA002446990A Expired - Fee Related CA2446990C (en) | 2001-05-24 | 2002-05-17 | Delivery of sedative-hypnotics through an inhalation route |
CA002446917A Expired - Lifetime CA2446917C (en) | 2001-05-24 | 2002-05-20 | Delivery of antipsychotics through an inhalation route |
CA002447521A Expired - Fee Related CA2447521C (en) | 2001-05-24 | 2002-05-21 | Delivery of antihistamines through an inhalation route |
CA002446916A Expired - Fee Related CA2446916C (en) | 2001-05-24 | 2002-05-21 | Delivery of opioids through an inhalation route |
CA002447166A Expired - Fee Related CA2447166C (en) | 2001-05-24 | 2002-05-22 | Delivery of erectile dysfunction drugs through an inhalation route |
CA2447099A Expired - Fee Related CA2447099C (en) | 2001-05-24 | 2002-05-23 | Delivery of compounds for the treatment of migraine through an inhalation route |
Family Applications Before (5)
Application Number | Title | Priority Date | Filing Date |
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CA002446904A Abandoned CA2446904A1 (en) | 2001-05-24 | 2002-05-13 | Delivery of drug esters through an inhalation route |
CA002446990A Expired - Fee Related CA2446990C (en) | 2001-05-24 | 2002-05-17 | Delivery of sedative-hypnotics through an inhalation route |
CA002446917A Expired - Lifetime CA2446917C (en) | 2001-05-24 | 2002-05-20 | Delivery of antipsychotics through an inhalation route |
CA002447521A Expired - Fee Related CA2447521C (en) | 2001-05-24 | 2002-05-21 | Delivery of antihistamines through an inhalation route |
CA002446916A Expired - Fee Related CA2446916C (en) | 2001-05-24 | 2002-05-21 | Delivery of opioids through an inhalation route |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
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CA2447099A Expired - Fee Related CA2447099C (en) | 2001-05-24 | 2002-05-23 | Delivery of compounds for the treatment of migraine through an inhalation route |
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- 2002-05-17 EP EP02771848A patent/EP1392264B1/en not_active Expired - Lifetime
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- 2002-05-20 AT AT08014272T patent/ATE462421T1/en not_active IP Right Cessation
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- 2002-05-20 ES ES02737053T patent/ES2311607T3/en not_active Expired - Lifetime
- 2002-05-20 US US10/153,139 patent/US6814954B2/en not_active Expired - Lifetime
- 2002-05-20 PL PL02363996A patent/PL363996A1/en unknown
- 2002-05-20 EP EP02731896A patent/EP1389097B1/en not_active Expired - Lifetime
- 2002-05-20 PT PT02737053T patent/PT1389098E/en unknown
- 2002-05-20 US US10/152,652 patent/US6740307B2/en not_active Expired - Fee Related
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- 2002-05-20 DK DK02737053T patent/DK1389098T3/en active
- 2002-05-20 US US10/152,639 patent/US6716416B2/en not_active Expired - Lifetime
- 2002-05-20 AT AT02737053T patent/ATE404173T1/en active
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- 2002-05-20 WO PCT/US2002/016118 patent/WO2002094236A1/en active Application Filing
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- 2002-05-21 JP JP2002590964A patent/JP2004535403A/en active Pending
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2003
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2004
- 2004-01-27 US US10/766,566 patent/US7060254B2/en not_active Expired - Fee Related
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- 2004-01-29 US US10/768,293 patent/US7067114B2/en not_active Expired - Fee Related
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2006
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- 2006-04-04 US US11/398,383 patent/US7449172B2/en active Active
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- 2006-06-30 US US11/479,892 patent/US7449174B2/en not_active Expired - Fee Related
- 2006-07-05 US US11/481,279 patent/US7449175B2/en not_active Expired - Fee Related
- 2006-07-18 US US11/488,932 patent/US7601337B2/en not_active Expired - Lifetime
- 2006-07-18 US US11/488,943 patent/US20060257329A1/en not_active Abandoned
- 2006-08-07 US US11/501,246 patent/US7510702B2/en not_active Expired - Fee Related
- 2006-08-07 US US11/500,735 patent/US7445768B2/en not_active Expired - Fee Related
- 2006-08-22 US US11/507,986 patent/US7491047B2/en not_active Expired - Fee Related
- 2006-09-19 US US11/523,685 patent/US7507397B2/en not_active Expired - Fee Related
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2007
- 2007-01-09 US US11/621,397 patent/US7468179B2/en not_active Expired - Fee Related
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2008
- 2008-03-27 US US12/057,330 patent/US7988952B2/en not_active Expired - Fee Related
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2009
- 2009-03-27 US US12/413,339 patent/US8173107B2/en not_active Expired - Lifetime
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2010
- 2010-07-23 JP JP2010165688A patent/JP5629151B2/en not_active Expired - Lifetime
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2013
- 2013-08-19 BE BE2013C054C patent/BE2013C054I2/nl unknown
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