CA2482441A1 - Automated high volume slide staining system - Google Patents

Automated high volume slide staining system Download PDF

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Publication number
CA2482441A1
CA2482441A1 CA002482441A CA2482441A CA2482441A1 CA 2482441 A1 CA2482441 A1 CA 2482441A1 CA 002482441 A CA002482441 A CA 002482441A CA 2482441 A CA2482441 A CA 2482441A CA 2482441 A1 CA2482441 A1 CA 2482441A1
Authority
CA
Canada
Prior art keywords
waxing
processing apparatus
paraffinizing
station
slides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002482441A
Other languages
French (fr)
Other versions
CA2482441C (en
Inventor
Kurt Reinhardt
Charles D. Lemme
Glen Ward
William Richards
Wayne Showalter
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ventana Medical Systems Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to CA2695837A priority Critical patent/CA2695837C/en
Publication of CA2482441A1 publication Critical patent/CA2482441A1/en
Application granted granted Critical
Publication of CA2482441C publication Critical patent/CA2482441C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L9/00—Supporting devices; Holding devices
    • B01L9/52—Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/30—Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis
    • G01N1/31—Apparatus therefor
    • G01N1/312—Apparatus therefor for samples mounted on planar substrates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/36—Embedding or analogous mounting of samples
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0822—Slides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/11—Automated chemical analysis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/11—Automated chemical analysis
    • Y10T436/112499—Automated chemical analysis with sample on test slide
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation

Abstract

An automated slide processing apparatus (20) includes a plurality of work stations (120, 140, 160, 180) arranged in a stack, and a transport/elevator (52) for transporting slides between the various work stations. In particular the device is for deparaffinizing, staining and coverslipping a plurality of biological specimen bearing slides (56), in a fully automated and integrated system.

Claims (51)

1. An automated slide processing apparatus comprising:
a plurality of work stations arranged vertically in a stack; and a transport/elevator for transporting slides between said work stations.
2. An automated slide processing apparatus according to claim 1, and further including a computer for controlling said stations and said transport/elevator.
3. An automated slide processing apparatus according to claim 1, wherein at least one of said stations comprises a baking or drying station.
4. An automated slide processing apparatus according to claim 3, wherein said drying or baking station comprises a convection heater.
5. An automated slide processing apparatus according to claim 1, wherein at least one of said work stations comprises a de-waxing or de-paraffinizing station.
6. An automated slide processing apparatus according to claim 5, wherein said de-waxing or de-paraffinizing station includes a plurality of fluid dispensing nozzles arranged to supply a de-waxing or de-paraffinizing fluid onto said slides.
7. An automated slide processing apparatus according to claim 6, wherein said de-waxing or de-paraffinizing fluid comprises an aqueous-based fluid.
8. An automated slide processing apparatus according to claim 1, wherein at least one of said stations comprises a staining station.
9. An automated slide processing apparatus according to claim 8, wherein said staining station includes a plurality of nozzles for applying selected stains or rinse fluids onto said slides.
10. An automated slide processing apparatus according to claim 9, and further comprising a plurality of stain supplies selectively connected to said nozzles.
11. An automated slide processing apparatus according to claim 1, wherein said work station comprises a coverslipping station.
12. An automated slide processing apparatus according to claim 11, wherein said coverslipping station is adapted to apply a glass coverslip to said slide.
13. An automated slide processing apparatus according to claim 1, and further comprising a slide tray for supporting a plurality of slides as they are carried through said apparatus.
14. An automated slide processing apparatus according to claim 13, wherein said transport/elevator comprises an X-Y-Z transport mechanism.
15. An automated slide processing apparatus according to claim 6, and further comprising a filter and recirculator for filtering and recirculating de-waxing or de-paraffinizing fluid.
16. An automated slide processing apparatus according to claim 1, and comprising a plurality of stacks of work stations operatively disposed adjacent a common transport/elevator.
17. An automated slide processing apparatus according to claim 7, and further including a heater for heating said aqueous-based fluid.
18. A de-waxing or de-paraffinizing station for processing specimen slides, and comprising, a reservoir containing an aqueous-based de-waxing or de-paraffinizing fluid; a heater for heating said aqueous-based fluid; a sprayer for spraying said heated aqueous-based fluid onto said slides; a collector for collecting and returning the aqueous-based fluid to the reservoir; and a filter for filtering the aqueous-based fluid for reuse.
19. A de-waxing or de-paraffinizing station as claimed in claim 18, wherein said filter is located between said collector and said reservoir.
20. A de-waxing or de-paraffinizing station as claimed in claim 18, and further comprising a tray for holding a plurality of specimen slides, spaced from one another, in a substantially horizontal orientation.
21. A de-waxing or de-paraffinizing station as claimed in claim 18, and further comprising a plurality of spray nozzles for spraying said de-waxing or de-paraffinizing fluid onto said slides.
22. A de-waxing or de-paraffinizing station as claimed in claim 20, wherein said tray has a sloped bottom wall, and further including an aspirator for drawing spent de-waxing or de-paraffinizing fluid from adjacent a low point of said sloped bottom wall.
23. A de-waxing or de-paraffinizing station as claimed in claim 20, wherein said tray includes a rack for holding said plurality of slides, spaced from one another, above the bottom wall of the tray.
24. A de-waxing or de-paraffinizing station as claimed in claim 23, wherein said rack includes a plurality of supports that limit axial, lateral and vertical movement of slides in the tray.
25. A de-waxing or de-paraffinizing station as claimed in claim 23, wherein said rack is adapted to hold a plurality of slides in spaced-apart rows.
26. An automated slide processing apparatus comprising:
a plurality of work stations arranged vertically in a stack; and a transport/elevator for transporting said slides between said work stations, wherein one of said work stations comprises a combined baking or drying and de-waxing or de-paraffinizing station.
27. An automated slide processing apparatus according to claim 26, and further including a computer for controlling said stations and said transport/elevator.
28. An automated slide processing apparatus according to claim 26, wherein said combined baking or drying and de-waxing or de-paraffinizing station comprises at least one radiant heater.
29. An automated slide processing apparatus according to claim 26, wherein said combined baking or drying and de-waxing or de-paraffinizing station includes a plurality of fluid dispensing nozzles arranged to supply a de-waxing or de-paraffinizing fluid onto pre-heated slides.
30. An automated slide processing apparatus according to claim 27, wherein said de-waxing or de-paraffinizing fluid comprises an aqueous-based fluid.
31. An automated slide processing apparatus according to claim 26, wherein said de-waxing or de-paraffinizing fluid comprises from about 3 to about 30 volume percent Collaterge.TM.
32. An automated slide processing apparatus according to claim 26, and further comprising a staining station.
33. An automated slide processing apparatus according to claim 32, wherein said staining station includes a plurality of nozzles for applying selected stains onto said slides.
34. An automated slide processing apparatus according to claim 33, and further comprising a plurality of stain supplies selectively connected to said nozzles.
35. An automated slide processing apparatus according to claim 26, and further comprising a coverslipping station.
36. An automated slide processing apparatus according to claim 35, wherein said coverslipping station is adapted to apply a glass coverslip to said slide.
37. An automated slide processing apparatus according to claim 36, and further comprising a slide tray for supporting a plurality of slides as they are carried through said apparatus.
38. An automated slide processing apparatus according to claim 37, wherein said transport/elevator comprises an X-Y-Z transport mechanism.
39. An automated slide processing apparatus according to claim 26, and comprising a plurality of stacks of work stations operatively disposed adjacent a common transport/elevator.
40. A combined baking or drying and de-waxing or de-paraffinizing station for processing specimen slides, comprising a radiant heater for heating said slides, and a sprayer for spraying de-waxing or de-paraffinizing fluid from a reservoir onto said heated slides.
41. A combined baking or drying and de-waxing or de-paraffinizing station as claimed in claim 40, and further comprising a sprayer for spraying a rinse fluid onto said slides.
42. A combined baking or drying and de-waxing or de-paraffinizing station as claimed in claim 40, and further comprising a tray for holding a plurality of specimen slides, spaced from one another, in a substantially horizontal orientation.
43. A combined baking or drying and de-waxing or de-paraffinizing station as claimed in claim 40, and further comprising a plurality of spray nozzles for spraying said de-waxing or de-paraffinizing fluid onto said slides.
44. A combined baking or drying and de-waxing or de-paraffinizing station as claimed in claim 42, wherein said tray has a sloped bottom wall, and further including an aspirator for drawing spent de-waxing or de-paraffinizing fluid from adjacent a low point of said sloped bottom wall.
45. A combined baking or drying and de-waxing or de-paraffinizing station as claimed in claim 42, wherein said tray includes a rack for holding said plurality of slides, spaced from one another, above the bottom wall of the tray.
46. A combined baking or drying and de-waxing or de-paraffinizing station as claimed in claim 45, wherein said rack includes a plurality of supports that limit axial, lateral and vertical movement of slides in the tray.
47. A combined baking or drying and de-waxing or de-paraffinizing station as claimed in claim 47, wherein said rack is adapted to hold a plurality of slides in spaced-apart rows.
48. A method of automatically preparing tissue samples on microscope slides for pathological analysis, comprising:
baking the tissue sample onto the slide by having the instrument apply heat to the tissue sufficient to adhere it to the slide;
deparaffinizing the tissue sample by contacting it with deparaffinizing fluid at a temperature above the melting point of the paraffin, and subsequently rinsing the liquefied paraffin away;
staining the tissue sample by contacting it with a staining reagent; and coverslipping the slide.
49. The method of claim 48, wherein said slide is coverslipped by contacting the stained tissue sample on the slide with a pre-glued coverslip and an adhesive activating fluid.
50. The method of claim 47 wherein said deparaffinizing fluid comprises water and a surfactant.
51. The method of claim 48 wherein said staining reagent comprises hematoxylin and eosin.
CA2482441A 2002-04-15 2003-04-15 Automated high volume slide staining system Expired - Lifetime CA2482441C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA2695837A CA2695837C (en) 2002-04-15 2003-04-15 Automated high volume slide staining system

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US37250602P 2002-04-15 2002-04-15
US60/372,506 2002-04-15
PCT/US2003/011651 WO2003089140A1 (en) 2002-04-15 2003-04-15 Automated high volume slide staining system

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CA2695837A Division CA2695837C (en) 2002-04-15 2003-04-15 Automated high volume slide staining system

Publications (2)

Publication Number Publication Date
CA2482441A1 true CA2482441A1 (en) 2003-10-30
CA2482441C CA2482441C (en) 2010-06-22

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Country Status (8)

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US (2) US7303725B2 (en)
EP (2) EP1890127B1 (en)
JP (2) JP4299150B2 (en)
AU (1) AU2003224987B2 (en)
CA (2) CA2695837C (en)
DK (2) DK1494808T3 (en)
ES (2) ES2425689T3 (en)
WO (1) WO2003089140A1 (en)

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