CA2504591A1 - A semi-biological intervertebral disc replacement system - Google Patents

A semi-biological intervertebral disc replacement system Download PDF

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Publication number
CA2504591A1
CA2504591A1 CA002504591A CA2504591A CA2504591A1 CA 2504591 A1 CA2504591 A1 CA 2504591A1 CA 002504591 A CA002504591 A CA 002504591A CA 2504591 A CA2504591 A CA 2504591A CA 2504591 A1 CA2504591 A1 CA 2504591A1
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CA
Canada
Prior art keywords
promoting material
tissue
tissue promoting
nuclear replacement
cavity
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002504591A
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French (fr)
Other versions
CA2504591C (en
Inventor
Stephen D. Kuslich
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Spineology Inc
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Individual
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Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to CA2735324A priority Critical patent/CA2735324A1/en
Priority to CA2735334A priority patent/CA2735334A1/en
Publication of CA2504591A1 publication Critical patent/CA2504591A1/en
Application granted granted Critical
Publication of CA2504591C publication Critical patent/CA2504591C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/44—Joints for the spine, e.g. vertebrae, spinal discs
    • A61F2/442—Intervertebral or spinal discs, e.g. resilient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/46—Special tools or methods for implanting or extracting artificial joints, accessories, bone grafts or substitutes, or particular adaptations therefor
    • A61F2/4603—Special tools or methods for implanting or extracting artificial joints, accessories, bone grafts or substitutes, or particular adaptations therefor for insertion or extraction of endoprosthetic joints or of accessories thereof
    • A61F2/4611—Special tools or methods for implanting or extracting artificial joints, accessories, bone grafts or substitutes, or particular adaptations therefor for insertion or extraction of endoprosthetic joints or of accessories thereof of spinal prostheses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/28—Bones
    • A61F2002/2817—Bone stimulation by chemical reactions or by osteogenic or biological products for enhancing ossification, e.g. by bone morphogenetic or morphogenic proteins [BMP] or by transforming growth factors [TGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/28—Bones
    • A61F2002/2835—Bone graft implants for filling a bony defect or an endoprosthesis cavity, e.g. by synthetic material or biological material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30003—Material related properties of the prosthesis or of a coating on the prosthesis
    • A61F2002/3006—Properties of materials and coating materials
    • A61F2002/30075—Properties of materials and coating materials swellable, e.g. when wetted
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/44—Joints for the spine, e.g. vertebrae, spinal discs
    • A61F2/442—Intervertebral or spinal discs, e.g. resilient
    • A61F2002/444—Intervertebral or spinal discs, e.g. resilient for replacing the nucleus pulposus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/44—Joints for the spine, e.g. vertebrae, spinal discs
    • A61F2002/4495—Joints for the spine, e.g. vertebrae, spinal discs having a fabric structure, e.g. made from wires or fibres
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/46—Special tools or methods for implanting or extracting artificial joints, accessories, bone grafts or substitutes, or particular adaptations therefor
    • A61F2/4603—Special tools or methods for implanting or extracting artificial joints, accessories, bone grafts or substitutes, or particular adaptations therefor for insertion or extraction of endoprosthetic joints or of accessories thereof
    • A61F2002/4625—Special tools or methods for implanting or extracting artificial joints, accessories, bone grafts or substitutes, or particular adaptations therefor for insertion or extraction of endoprosthetic joints or of accessories thereof with relative movement between parts of the instrument during use
    • A61F2002/4627—Special tools or methods for implanting or extracting artificial joints, accessories, bone grafts or substitutes, or particular adaptations therefor for insertion or extraction of endoprosthetic joints or of accessories thereof with relative movement between parts of the instrument during use with linear motion along or rotating motion about the instrument axis or the implantation direction, e.g. telescopic, along a guiding rod, screwing inside the instrument
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2210/00—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2210/0061—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof swellable

Abstract

The present invention is a system for a partially biological disc replacement that stimulates natural fibrous, cartilaginous or other tissue growth in the DDD cavity (24), resulting in a partial biological disc replacement (10).
Multiplicities of fibronous pieces of fribro-cartilaginous tissue promoting material (26) are inserted into the DDD cavity (24) inducing tissue growth.
The fibro-cartilaginous tissue

Claims (52)

1. A system for semi-biologic nuclear replacement for a degenerated disc of a spine of a mammalian body comprising:
an injection tube having a small diameter corresponding to a small entrance hole defined in the degenerated disc that is at least partially excavated to create a cavity;
a volume of tissue promoting material sufficient to fill at least a portion of the cavity; and an insertion device operably coupled to the injection tube that dispenses the volume of tissue promoting material into the cavity in a piecemeal manner as a plurality of aliquots of the tissue promoting material.
2. The nuclear replacement of claim 1 wherein the tissue promoting material is selected from a group consisting of fibrous tissue promoting material, cartilaginous promoting material and any combination thereof.
3. The nuclear replacement of claim 1 wherein the tissue promoting material is a preparation of multilayered bands piled in a circular configuration.
4. The nuclear replacement of claim 1 wherein the tissue promoting material is a preparation of tangled knots.
5. The nuclear replacement of claim 1 wherein the tissue promoting material is a preparation of multiple fabric bands.
6. The nuclear replacement of claim 1 wherein the tissue promoting material is combined with hydrogel.
7. The nuclear replacement of claim 1 wherein the tissue promoting material is surrounded by a porous container.
8. The nuclear replacement of claim 1 wherein the tissue promoting material is selected from a group consisting of: autograft, allograft, or xenograft of fascia, manmade polymeric fiber, talc, tissue promoting pharmaceuticals, tissue promoting minerals, tissue morphogenic protein, notochord cells and any combination thereof.
9. A system for semi-biologic nuclear replacement for a degenerated disc of a spine of a mammalian body comprising:
an injection tube having a small diameter corresponding to a small entrance hole defined in the degenerated disc that is at least partially excavated to create a cavity;
a volume of strands of tissue promoting material combined with hydrogel strands sufficient to fill at least a portion of the cavity; and an insertion device operably coupled to the injection tube that dispenses the volume of strands of tissue promoting material combined with strands of hydrogel into the cavity in a piecemeal manner as a plurality of aliquots of the tissue promoting material and hydrogel strands.
10. The nuclear replacement of claim 9 wherein the tissue promoting material is selected from a group consisting of fibrous tissue promoting material, cartilaginous promoting material and any combination thereof.
11. The nuclear replacement of claim 9 wherein the tissue promoting material is a preparation of multilayered bands piled in a circular configuration.
12. The nuclear replacement of claim 9 wherein the tissue promoting material is a preparation of tangled knots.
13. The nuclear replacement of claim 9 wherein the tissue promoting material is a preparation of multiple fabric bands.
14. The nuclear replacement of claim 9 wherein the tissue promoting material is surrounded by a porous container.
15. The nuclear replacement of claim 9 wherein the tissue promoting material is selected from a group comprising: autograft, allograft, or xenograft of fascia, autograft, manmade polymeric fiber, talc, tissue promoting pharmaceuticals, tissue promoting minerals, tissue morphogenic protein, notochord cells and any combination thereof.
16. A system for semi-biologic nuclear replacement for a degenerated disc of a spine of a mammalian body comprising:
an injection tube having a small diameter corresponding to a small entrance hole defined in the degenerated disc that is at least partially excavated to create a cavity;
at least one strand of pliable tissue promoting material having an effective cross-sectional diameter less than the small diameter of the injection tube;
the at least one strand of pliable tissue promoting material having a volume sufficient to fill at least a portion of the cavity; and an insertion device operably coupled to the injection tube that dispenses a length of the pliable tissue promoting material into the cavity such that the at least one strand is folded so as to fill at least a portion of the cavity.
17. The nuclear replacement of claim 1 wherein the tissue promoting material is selected from a group consisting of fibrous tissue promoting material, cartilaginous promoting material and any combination thereof.
18. The nuclear replacement of claim 16 wherein the tissue promoting material is a preparation of multilayered bands piled in a circular configuration.
19. The nuclear replacement of claim 16 wherein the tissue promoting material is a preparation of tangled knots.
20. The nuclear replacement of claim 16 wherein the tissue promoting material is a preparation of multiple fabric bands.
21. The nuclear replacement of claim 16 wherein the tissue promoting material is combined with hydrogel.
22. The nuclear replacement of claim 16 wherein the tissue promoting material is surrounded by a porous container.
23. The nuclear replacement of claim 16 wherein the tissue promoting material is selected from a group comprising: autograft, allograft, or xenograft of fascia, autograft, manmade polymeric fiber, talc, tissue promoting pharmaceuticals, tissue promoting minerals, tissue morphogenic protein, notochord cells and any combination thereof.
24. A method of constructing a semi-biologic nuclear replacement for a degenerated disc of a spine of a mammalian body comprising:
boring a small entrance hole into the degenerated disc;
creating a cavity by reaming the degenerated disc and at least partially removing a degenerated disc nucleus via the small entrance hole; and inserting a plurality of pieces of tissue promoting material into the cavity to create the semi-biologic nuclear replacement for the degenerated disc by stimulating the tissue forming response in the mammalian body to the tissue promoting material.
25. The method of claim 24 wherein the tissue promoting material is selected from a group consisting of fibrous tissue promoting material, cartilaginous promoting material and any combination thereof.
26. The method of claim 24 wherein endplate cartilage is partially removed.
27. The method of claim 24 wherein endplate cartilage is retained.
28. The method of claim 24 wherein portions of an outer annulus are removed.
29. The method of claim 24 wherein portions of an outer annulus are retained.
30. The method of claim 24 wherein the tissue promoting material is selected from a group comprising: autograft, allograft, or xenograft of fascia, manmade polymeric fiber, talc, tissue promoting pharmaceuticals, tissue promoting minerals, tissue morphogenic protein, notochord cells and any combination thereof.
31. The method of claim 24 wherein the disc cavity surface is coated with a tissue promoting material.
32. The method of claim 24 wherein the tissue promoting material is combined with hydrogel.
33. The method of claim 24 further comprising:
inserting a porous container into the disc cavity;
said porous container adapted for tissue promoting material insertion therein.
34. A method of constructing a semi-biologic nuclear replacement for a degenerated disc of a spine of a mammalian body comprising:
boring a small entrance hole into the degenerated disc;
creating a cavity by reaming the degenerated disc and at least partially removing a degenerated disc nucleus via the small entrance hole; and inserting at least one strand of pliable tissue promoting material into the cavity such that a length of the at least one strand is folded within the cavity to create the semi-biologic nuclear replacement for the degenerated disc by stimulating the tissue forming response in the mammalian body to the tissue promoting material.
35. The method of claim 34 wherein the tissue promoting material is selected from a group consisting of fibrous tissue promoting material, cartilaginous promoting material and any combination thereof.
36. The method of claim 34 wherein endplate cartilage is partially removed.
37. The method of claim 34 wherein the endplate cartilage is retained.
38. The method of claim 34 wherein portions of an outer annulus are removed.
39. The method of claim 34 wherein an outer annulus is retained.
40. The method of claim 34 wherein the tissue promoting material is selected from a group consisting of: autograft, allograft, or xenograft of fascia lata, autograft, manmade polymeric fiber, talc, tissue promoting pharmaceuticals, tissue promoting minerals, tissue morphogenic protein, notochord cells, and any combination thereof.
41. The method of claim 34 wherein the disc cavity surface is coated with a tissue promoting material.
42. The method of claim 34 wherein the tissue promoting material is combined with hydrogel.
43. The method of claim 34 further comprising:
inserting a porous container into the disc cavity;

said porous container adpapted for tissue promoting material insertion therein.
44. A method of constructing a semi-biologic nuclear replacement for a degenerated disc of a spine of a mammalian body comprising:
boring a small entrance hole into the degenerated disc;
creating a cavity by reaming the degenerated disc and at least partially removing a degenerated disc nucleus via the small entrance hole; and inserting a plurality of pieces of tissue promoting material combined with a plurality of pieces of hydrogel into the cavity to create the semi-biologic nuclear replacement for the degenerated disc by stimulating the tissue forming response in the mammalian body to the tissue promoting material and hydrogel.
45. The nuclear replacement of claim 44 wherein the tissue promoting material is selected from a group consisting of fibrous tissue promoting material, cartilaginous promoting material and any combination thereof.
46. The method of claim 44 wherein endplate cartilage is partially removed.
47. The method of claim 44 wherein the endplate cartilage is retained.
48. The method of claim 44 wherein portions of an outer annulus are removed.
49. The method of claim 44 wherein an outer annulus is retained.
50. The method of claim 44 wherein the tissue promoting material is selected from a group consisting of: autograft, allograft, or xenograft of fascia lata, autograft, manmade polymeric fiber, talc, tissue promoting pharmaceuticals, tissue promoting minerals, tissue morphogenic protein, notochord cells, and any combination thereof.
51. The method of claim 44 wherein the disc cavity surface is coated with a tissue promoting material.
52. The method of claim 44 further comprising:
inserting a porous container into the disc cavity;
said porous container adapted for tissue promoting material insertion therein.
CA2504591A 2002-11-05 2003-11-05 A semi-biological intervertebral disc replacement system Expired - Fee Related CA2504591C (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CA2735324A CA2735324A1 (en) 2002-11-05 2003-11-05 A semi-biological intervertebral disc replacement system
CA2735334A CA2735334A1 (en) 2002-11-05 2003-11-05 A semi-biological intervertebral disc replacement system

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US42390002P 2002-11-05 2002-11-05
US60/423,900 2002-11-05
PCT/US2003/035450 WO2004041075A2 (en) 2002-11-05 2003-11-05 A semi-biological intervertebral disc replacement system

Related Child Applications (2)

Application Number Title Priority Date Filing Date
CA2735324A Division CA2735324A1 (en) 2002-11-05 2003-11-05 A semi-biological intervertebral disc replacement system
CA2735334A Division CA2735334A1 (en) 2002-11-05 2003-11-05 A semi-biological intervertebral disc replacement system

Publications (2)

Publication Number Publication Date
CA2504591A1 true CA2504591A1 (en) 2004-05-21
CA2504591C CA2504591C (en) 2011-09-13

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Family Applications (3)

Application Number Title Priority Date Filing Date
CA2504591A Expired - Fee Related CA2504591C (en) 2002-11-05 2003-11-05 A semi-biological intervertebral disc replacement system
CA2735324A Abandoned CA2735324A1 (en) 2002-11-05 2003-11-05 A semi-biological intervertebral disc replacement system
CA2735334A Abandoned CA2735334A1 (en) 2002-11-05 2003-11-05 A semi-biological intervertebral disc replacement system

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CA2735324A Abandoned CA2735324A1 (en) 2002-11-05 2003-11-05 A semi-biological intervertebral disc replacement system
CA2735334A Abandoned CA2735334A1 (en) 2002-11-05 2003-11-05 A semi-biological intervertebral disc replacement system

Country Status (8)

Country Link
US (3) US20050055094A1 (en)
EP (1) EP1562524A4 (en)
JP (1) JP2006505331A (en)
KR (1) KR20050084658A (en)
AU (2) AU2003290627B2 (en)
CA (3) CA2504591C (en)
NZ (1) NZ539779A (en)
WO (1) WO2004041075A2 (en)

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AU2009202358A1 (en) 2009-07-02
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WO2004041075A2 (en) 2004-05-21
AU2003290627B2 (en) 2009-03-19
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NZ539779A (en) 2009-01-31
US8012211B2 (en) 2011-09-06

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