CA2519937C - Speckle reduction in optical coherence tomography by path length encoded angular compounding - Google Patents

Speckle reduction in optical coherence tomography by path length encoded angular compounding Download PDF

Info

Publication number
CA2519937C
CA2519937C CA2519937A CA2519937A CA2519937C CA 2519937 C CA2519937 C CA 2519937C CA 2519937 A CA2519937 A CA 2519937A CA 2519937 A CA2519937 A CA 2519937A CA 2519937 C CA2519937 C CA 2519937C
Authority
CA
Canada
Prior art keywords
radiation
oct
radiations
delay
sample
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2519937A
Other languages
French (fr)
Other versions
CA2519937A1 (en
Inventor
Guillermo J. Tearney
Nicusor Iftimia
Brett E. Bouma
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
General Hospital Corp
Original Assignee
General Hospital Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by General Hospital Corp filed Critical General Hospital Corp
Publication of CA2519937A1 publication Critical patent/CA2519937A1/en
Application granted granted Critical
Publication of CA2519937C publication Critical patent/CA2519937C/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0062Arrangements for scanning
    • A61B5/0066Optical coherence imaging
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/68Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6846Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
    • A61B5/6847Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive mounted on an invasive device
    • A61B5/6852Catheters
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01BMEASURING LENGTH, THICKNESS OR SIMILAR LINEAR DIMENSIONS; MEASURING ANGLES; MEASURING AREAS; MEASURING IRREGULARITIES OF SURFACES OR CONTOURS
    • G01B9/00Measuring instruments characterised by the use of optical techniques
    • G01B9/02Interferometers
    • G01B9/02015Interferometers characterised by the beam path configuration
    • G01B9/02027Two or more interferometric channels or interferometers
    • G01B9/02028Two or more reference or object arms in one interferometer
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01BMEASURING LENGTH, THICKNESS OR SIMILAR LINEAR DIMENSIONS; MEASURING ANGLES; MEASURING AREAS; MEASURING IRREGULARITIES OF SURFACES OR CONTOURS
    • G01B9/00Measuring instruments characterised by the use of optical techniques
    • G01B9/02Interferometers
    • G01B9/02055Reduction or prevention of errors; Testing; Calibration
    • G01B9/02075Reduction or prevention of errors; Testing; Calibration of particular errors
    • G01B9/02082Caused by speckles
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01BMEASURING LENGTH, THICKNESS OR SIMILAR LINEAR DIMENSIONS; MEASURING ANGLES; MEASURING AREAS; MEASURING IRREGULARITIES OF SURFACES OR CONTOURS
    • G01B9/00Measuring instruments characterised by the use of optical techniques
    • G01B9/02Interferometers
    • G01B9/02083Interferometers characterised by particular signal processing and presentation
    • G01B9/02087Combining two or more images of the same region
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01BMEASURING LENGTH, THICKNESS OR SIMILAR LINEAR DIMENSIONS; MEASURING ANGLES; MEASURING AREAS; MEASURING IRREGULARITIES OF SURFACES OR CONTOURS
    • G01B9/00Measuring instruments characterised by the use of optical techniques
    • G01B9/02Interferometers
    • G01B9/0209Low-coherence interferometers
    • G01B9/02091Tomographic interferometers, e.g. based on optical coherence
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/47Scattering, i.e. diffuse reflection
    • G01N21/4795Scattering, i.e. diffuse reflection spatially resolved investigating of object in scattering medium
    • GPHYSICS
    • G02OPTICS
    • G02BOPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B27/00Optical systems or apparatus not provided for by any of the groups G02B1/00 - G02B26/00, G02B30/00
    • G02B27/48Laser speckle optics
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01JMEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J9/00Measuring optical phase difference; Determining degree of coherence; Measuring optical wavelength
    • G01J9/02Measuring optical phase difference; Determining degree of coherence; Measuring optical wavelength by interferometric methods
    • G01J9/0215Measuring optical phase difference; Determining degree of coherence; Measuring optical wavelength by interferometric methods by shearing interferometric methods
    • GPHYSICS
    • G02OPTICS
    • G02BOPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B26/00Optical devices or arrangements for the control of light using movable or deformable optical elements
    • G02B26/08Optical devices or arrangements for the control of light using movable or deformable optical elements for controlling the direction of light
    • G02B26/10Scanning systems
    • G02B26/105Scanning systems with one or more pivoting mirrors or galvano-mirrors

Abstract

An apparatus irradiating a sample is provided. Such apparatus can include an interferometer forwarding an electromagnetic radiation and a sample arm receiving the electromagnetic radiation.
The sample arm can include an arrangement which is configured to produce at least two radiations from the electromagnetic radiation so as to irradiate the sample, and to delay a first radiation of the at least two radiations with respect to a second radiation of the at least two radiations. For example, the delay of a path of the first radiation compared to a path of the second radiation can be at least 500µm in air.

Description

SPECKLE REDUCTION IN OPTICAL COHERENCE TOMOGRAPHY BY
PATH LENGTH ENCODED ANGULAR COMPOUNDING

FIELD OF THE INVENTION

The present invention relates to optical imaging methods and apparatus useful in medical diagnosis and imaging. In particular, the present invention relates to a high speed method for implementing angular compounding, e.g., angular compounding by path length encoding ("ACPE") for reducing speckle in optical coherence tomography images.

BACKGROUND INFORMATION

Optical coherence tomography ("OCT") is a technique for obtaining high resolution cross-sectional images of biological tissues. Clinical OCT studies conducted in the gastrointestinal tract and cardiovascular system have shown that OCT is capable of providing images of the architectural (>20 m) microanatomy of a variety of epithelial tissues, including the layered structure of squamous epithelium and arterial vessels. However, for certain medical applications, such as the early detection of high-grade dysplasia in Barrett's esophagus and the identification of inflammation within atherosclerotic plaques, visualization of structures that are on a size scale of < 20 m may be preferable. OCT systems, with typical axial resolutions ranging from 8 - 12 gm, have the potential to resolve many of these structures, including nuclei, individual glands, and macrophages.
Unfortunately, speckle, which occurs on the same size scale as these features, may prohibit unambiguous including nuclei, individual glands, and macrophages.
Unfortunately, speckle, which occurs on the same size scale as these features, may prohibit unambiguous identification of the cellular and subcellular tissue components required for widespread clinical utilization of such technology.

Catheter or endoscope access and high-speed imaging is used in order to perform OCT in the internal organs of patients. In order to minimize diameter, most catheter-based OCT probes employ a single optical fiber to illuminate the sample and detect the signal from the tissue. High frame rates (typically 4-10 frames per second) are preferred for performing OCT imaging while minimizing artifacts caused by patient motion. A way to reduce speckle in OCT images that does not significantly increase the complexity of single optical fiber probe designs while maintaining high frame rates may be beneficial for applying OCT to accurately detect and quantify key microscopic tissue structures in patients.

The reduction of speckle in the OCT images speckle has been previously described. A publication by J. M. Schmitt, "Array Detection for Speckle Reduction in Optical Coherence Microscopy," Phys. Med. Biol. 42, 1427-1429, 1997 describes a procedure for a speckle reduction by averaging multiple images acquired at different angles, known as angular compounding. In this publication, multiple (N) detectors receive images that have been acquired from different angles. The images are averaged incoherently, providing an improvement ('N) in the signal to noise ratio ("SNR"). While this technique has the advantage that the measurements may be performed in real-time, the experimental apparatus as described therein would not be compatible with a single fiber optic catheter.

Another publication, M. Bashkansky and J. Reintjes, "Statistics and reduction of Speckle in Optical Coherence Tomography," Opt. Lett. 25,545-547, describes an alternative technique for angular compounding to reduce speckle.
In this method, a retroreflector apparatus is translated in front of the objective lens to change the angle of the incident beam on the tissue. N successive images are acquired and added incoherently to reduce speckle, again improving the SNR by a factor of 4.
While this method may be less complex than the use of multiple detectors, the time needed thereby to acquire the images is increased by N. In addition, the implementation of this method within the confines of a small diameter catheter or endoscope could be difficult.
SUMMARY OF THE INVENTION

In accordance with a first aspect, the present invention provides an apparatus irradiating a sample, the apparatus comprising an interferometer forwarding an electromagnetic radiation and a sample arm receiving the electromagnetic radiation. The sample arm includes an arrangement which is configured to produce at least two radiations from the electromagnetic radiation so as to irradiate the sample, and to delay a first radiation of the at least two radiations with respect to a second radiation of the at least two radiations, wherein the delay of a path of the first radiation compared to a path of the second radiation is at least 500 m in air.

According to one exemplary embodiment of the present invention, a method for performing angular compounding to reduce speckle within OCT images is provided, which may use angular compounding by path length encoding ("ACPE"). With ACPE, a high-speed acquisition can be maintained, and modifications to standard OCT catheter optics are likely to be minimal. In another exemplary embodiment according to the present invention, an apparatus for imaging is provided that uses ACPE.

Accordingly, apparatus probe catheter, and method according to exemplary embodiments of the present invention are provided for irradiating a sample. In particular, an interferometer may forward forwarding an electromagnetic radiation. In addition, a sample arm may receive the electromagnetic radiation, and can include an arrangement which facilitates a production of at least two radiations from the electromagnetic radiation so as to irradiate the sample. Such arrangement can be configured to delay a first radiation of the at least two radiations with respect to a second radiation of the at least two radiations.

According to another exemplary embodiment of the present invention, a reference arm provides a further electromagnetic radiation. In particular, the interferometer receives the first, second and further radiations, and forms a resultant signal based on the first, second and further radiations. A processing arrangement may also be provided for generating a first image based on the first radiation and a second image based on the second radiation, such that the first and second images are different from one another.
The further image may be generated based on the first and second images. In addition, the further image may have a noise that is smaller than a noise of the first image and a noise of the second image. Also, the further image may have a signal to noise ratio that is improved according to the equation:

acr RaCPE var ~ , oc -t.o 3a where SNRACPE is the signal to noise ratio, SOCT is an amplitude of a high-pass filtered OCT signal, in is a thickness of the arrangement, ui is an amplitude of a demodulated OCT signal at a spatial location, and N = 2m - 1.
Further, m=2 and N=3 images associated with the at least two radiations may be obtained.
The further image may also be generated based on a mathematical combination of the first and second images.
According to yet another exemplary embodiment of the present invention, the sample can be irradiated by the first irradiation at a first angle, and by the second radiation at a second angle, such that the first and second angles different from one another. For example, the first and second angle maybe different from one another based on the delay and at least one of a phase and a incident angle of each of the first and second radiations. It is also possible to utilize a detector which detects the first electromagnetic energy, and forwards the detected energy to the processing arrangement.
hi still another exemplary embodiment of the present invention, the arrangement can include two sections, each being configured to delay a respective one of the first and second radiations. In particular, a delay of the first radiation is preferably greater than a delay of the second radiation. In addition, the delay of a path of the first radiation compared to a path of the second radiation is at least 500 m in air. Further, the delay of a path of the first radiation compared to a path of the second radiation is at least lmm in air. The arrangement may have a refractive index of at least 1.5 or at least 3Ø The arrangement can include silicon and/or an anti-reflective coating on at least one surface thereof. Such arrangement can be an anti-reflection-coated BK 7 glass. The glass may have a thickness of from about 1.6 mm to about 7.7 min, and a refractive index of from about 1.51 to about 3.5.
According to yet another exemplary embodiment of the present invention, an apparatus for imaging is provided. The apparatus includes a sample arm that receive an electromagnetic radiation. The sample arm includes an arrangement which facilitates a production of at least two radiations from the electromagnetic ' radiation so as to irradiate a sample. The arrangement is configured to delay a first radiation of the at least two radiations with respect to a second radiation of the at least two radiations. The apparatus also includes a device for receiving the first and second radiations from the sample arm and at least one third radiation from a reference arm, such that the first and second radiations interfere with the third radiation.
Further, the apparatus includes at least one of spectral separating unit which separates spectrum of at least one of the first, second and third radiations into frequency components, and at least one detection arrangement including a plurality of detectors. Each detector is capable of detecting at least a portion of at least one of the frequency components.
In a further exemplary embodiment of the present invention, an apparatus is provided. Such apparatus includes at least one first arrangement that provides at least one first electro-magnetic radiation to a sample arm and at least one second electro-magnetic radiation to a non-reflective reference arm. A
frequency of radiation provided by the first arrangement varies over time. The sample arm receives the first electromagnetic radiation, and includes an arrangement which facilitates a production of at least two radiations from the electromagnetic radiation so as to irradiate a sample. The arrangement is configured to delay a first radiation of the at least two radiations with respect to a second radiation of the at least two radiations.
The apparatus also includes at least one second arrangement detecting an interference between the first and second radiations generated at the sample arm and the second electro-magnetic radiations generated at the reference.
In still another exemplary embodiment of the present invention, an apparatus is provided. The apparatus includes a. at least one first arrangement providing at least one first electro-magnetic radiation to a sample arm and at least one second electro-magnetic radiation to a reference arm. The first and/or second electro-magnetic radiation have a spectrum which changes over time. The spectrum contains multiple frequencies at a particular time. The sample arm receives the first electromagnetic radiation, and includes an arrangement which facilitates a production of at least two radiations from the electromagnetic radiation so as to irradiate a sample. The arrangement is configured to delay a first radiation of the at least two radiations with respect to a second radiation of the at least two radiations.
The apparatus also includes at least one second arrangement detecting an interference between the first and second radiations generated at the sample arm and the second electro-magnetic radiations generated at the reference.
Other features and advantages of the present invention will become apparent upon reading the following detailed description of embodiments of the invention, when taken in conjunction with the appended claims.
BRIEF DESCRIPTION OF THE DRAWINGS

The invention is illustrated in the drawings in which like reference characters designate the same or similar parts throughout the figures of which:
Fig. IA is a schematic diagram of an exemplary embodiment of an ACPE-OCT apparatus according to the present invention.
Fig. 2A is a schematic diagram of an exemplary embodiment of an Intralipid-Agar phantom according to the present invention.
Fig. 2B is an exemplary OCT image of the phantom of Fig. 2A without the insertion of a BK7 ACPE element.
Fig. 2C is an illustration of exemplary ACPE OCT images obtained by splitting a sample beam in two parts using an exemplary 3.1 mm BK7 glass element.
Fig. 3A is an exemplary OCT image of a ventral forearm obtained in vivo prior to the insertion of the BK7 ACPE element.
Fig. 3B is an exemplary compounded ACPE OCT image of the skin acquired at the same location as that in Fig. 3A.

DETAILED DESCRIPTION

1. Materials and Methods Fig. 1A shows an exemplary embodiment of an apparatus according to the present invention which uses ACPE. An optical glass 20 is placed in an imaging path 10 of a conventional OCT imaging apparatus 5, splitting the incident field into two beamlets 1 and 2 which are provided on beam paths 30 and 40, respectively.
For the purpose of the present discussion, a beamlet can be defined as a portion of a beam.
An optical element (e.g., the optical glass 20) causes a portion of the incident beam (beamlet 2) to experience a greater path length delay than beamlet 1. In addition, beamlet 2 illuminates the sample at a different angle than beamlet 1. A lens may be provided to converge the beamlets 1 and 2 onto the sample (e.g., a tissue). As a result, multiple OCT images of a specimen in or on the sample, each acquired at a different angle, can appear simultaneously on the OCT display (see Fig. 1B).
In particular, Fig. 1B shows that the top image (i.e., labeled as 1 + 1) corresponds to the image formed from path 1 (i.e., incident and reflected), the middle image (i.e., labeled as 1 + 2, 2 + 1) corresponds to the image formed from path 1 incident, path 2 reflected and path 2 incident, path 1 reflected. Further, the bottom image (i.e., 2 + 2) of Fig. 1B
corresponds to the image formed from path 2 (incident and reflected).
These beamlets 1 and 2, thus encoded by optical path length, also illuminate the sample at different angles. As a result, multiple OCT images, each acquired at different angles, are preferably present in a single OCT frame (as shown in Fig. 1B). For example, when the optical element contains m distinct thicknesses of glass, with each optical thickness a multiple of the others, 2m -1 OCT images can be obtained in one OCT frame. Each image may be separated by a group delay of D(n -1)/2, where D is the thickness and n is the refractive index of the optical material. The distinct OCT images are then averaged to produce a composite OCT image with significantly reduced speckle. Since all of the images are acquired in one OCT
frame, single frame acquisition time can be maintained. In addition, the modifications to the OCT probe may involve only the insertion of at least one small optical element in the beam path of the distal optics. These advantages of ACPE allow speckle averaging to be performed within the confines of a small diameter catheter or endoscope, and without compromising the acquisition speed.
Previous attempts of utilizing OCT speckle reduction by image compounding has shown that the addition of N images of the same intensity provides an SNR increase by a factor of . For example, the Bashkansky publication described above describes that the speckle distribution in OCT takes the form of the probability density function:
(1) p{SOCT ) = 2crc exp 2 ~T

where x = 2AR6 , with AR is the amplitude of the reference field, SocT is the amplitude of the high-pass filtered OCT signal, and o- is its standard deviation. For this probability density function, it can be demonstrated that the SNR improvement obtained by averaging N images of the same amplitude is also a factor of J , a result that has been experimentally described in the Schmitt and Bashkansky publications. For ACPE, the distinct OCT subimages generally may not have equal amplitudes. However, with the assumption of isotropic backscattering, these subimages are related to the original OCT image, SOOCT, by /3%n2, where 6 is the number of path length combinations that contribute to a distinct subimage. As a result, the SNR for ACPE maybe defined as N (2) u;
SNR ACPE _ \SQCT / i=1 jVar[SOCT] 2 u i i=1 where u1 is the amplitude of the demodulated OCT signal at a spatial location, and N =
2m - 1. In the case of m=2, N= 3 images are obtained and the relationships between the amplitudes of the ACPE OCT subimages are S1OCT = S3 OCT =14 SOOCT and S20CT = 2S10CT =12SOOCT. The potential SNR improvement of the compounded in = 2 ACPE image can then become SNR ACPE / SNR0 =1.63, where SN O is the signal to noise ratio of SOOCT

EXAMPLES
11. Example 1 An exemplary polarization-diverse OCT system according to the present invention can be utilized for the examplary apparatus (e.g., as shown in Fig.
IA) that implements ACPE. Using such exemplary system according to the present invention, OCT images may be acquired at 2 frames per second (e.g., 500 axial pixels x 500 transverse pixels), which may be displayed with an inverse gray-scale lookup table, and digitally archived. The optical source which can be used in such exemplary OCT system may have a center wavelength of 1310 nm and a bandwidth of 70 nm, and thus providing an axial resolution of approximately 8 m in the tissue.
A modified hand-held galvanometer probe (e.g., the apparatus of Fig.
1A) can be inserted in the sample arm of the OCT system 5. The objective lens may have a focal length of 25 mm and a numerical aperture (NA) of 0.11, providing a measured l/e 2 focal spot diameter of 23 m. A square, antireflection-coated D
= 3.1 mm BK7 glass (n =1.51) (e.g., the optical glass 20, may be inserted between the optical fiber collimator and the objective lens 50 (see Fig. 1A) so that overlaps with half of the illuminating beam. With this exemplary configuration, an OCT image separation of approximately 800 m can be achieved. When the glass plate is inserted, the spot diameter perpendicular to the glass edge may increase by a factor of two (46 gm). In the plane of the OCT image, however, the transverse resolution is likely preserved.
III. Example 2 A solid phantom consisting of 1 % Intralipid solution and Agar can be used to measure a reduction in speckle provided by ACPE. For example, four (4) hairs can be embedded in the Intralipid-Agar gel at different transverse positions and depths. A schematic of the phantom is depicted in Fig. 2A. The corresponding OCT
images with and without the BK7 glass plate are shown in Figs. 2B and 2C, respectively. ROI's labeled 1-5 represent exemplary locations where the SNR
improvement by ACPE is preferably measured. The insertion of the BK7 glass plate (with a 3.1 mm BK7 glass element) in the sample arm can produce three copies of the original OCT image (see Fig. 2C), with each image being acquired at a different illumination angles and separated by group delay increments of, e.g., 800 gm.
The amplitudes of the signals in the top and bottom images of Fig. 2C can be 15 approximately half of the center image (SIOCTI S20CT = S30CTI S20CT = 1:2).
The compounded ACPE image shown in Fig. 2D can bes obtained by incoherently averaging the three images that are shown in Fig. 2C, A substantial reduction of speckle in the compounded image can be visualized in Fig. 2D. Compared to the original OCT image, the average ACPE SNR improvement for the five regions 20 depicted in Fig. 2B is preferably 1.54 0.12 (mean standard deviation).
IV. Example 3 In order to demonstrate SNR improvement in vivo, ACPE OCT
imaging can be performed on a ventral forearm of a subject. Figs. 3A and 3B
shows one representative set of images. Fig. 3A shows an exemplary OCT image of the ventral forearm obtained in vivo prior to the insertion of the BK7 ACPE
element.
Visual assessment of these pictures demonstrates a qualitative improvement in the compounded ACPE image (Fig. 3B). The boundary between the epidermis (E) and dennis (D) is more clearly demarcated with ACPE as shown in Fig. 3B. In addition, horizontal structures consistent with dermal vasculature are more readily identified in the ACPE image of Fig. 3B. The SNR can be measured for the ACPE and original OCT images in Fig. 3B, providing an exemplary SNR improvement of 1.56.
The apparatus and method according to the exemplary embodiments of the present invention are provide to reduce speckle in OCT images that does not decrease the OCT frame rate and requires only minor modifications to the OCT
probe.
The implementation of ACPE, implements potential compromises between speckle reduction and three other OCT system parameters: a) sample arm transverse resolution, b) total reference arm path length, and c) OCT image sensitivity.
In particular, for any given objective lens, ACPE may compromise the transverse resolution in one dimension by underfilling the lens aperture for each individual beamlet. In most cases, increasing the numerical aperture (NA) of the objective can compensate for this resolution loss.
Speckle averaged ACPE-OCT images can be obtained at the same rate as conventional OCT images by scanning an increased reference arm path length delay at substantially the same frequency. In order to acquire each of the individual OCT subimages, the new scan length of the ACPE-OCT system can preferably be L(2in -1), where L is the original scan length of the OCT system. Using phase control RSOD lines, scan ranges up to 10 mm are possible, thus enabling in = 3, L = 2 mm, and a maximum predicted SNR improvement of - 2.1.
Increasing the reference arm path length scan range while maintaining the scan rate, may increase the electronic bandwidth and decrease the sensitivity of the OCT system. Also, because ACPE splits the sample arm power into 2711-1 subimages, each subimage contains a fraction of the original sample arm power.
When imaging a human tissue, these losses may primarily affect the penetration depth of the OCT image. Since many features of clinical relevance, such as nuclei in patients with Barrett's esophagus or macrophages in atherosclerotic plaques, may bee present at tissue surfaces, for modest in, the improvements in image quality provided by ACPE likely outweigh sensitivity losses. Moreover, ongoing technical developments towards more efficient interferometer designs and higher power, clinically viable OCT sources may render ACPE sensitivity losses a non-issue.
The thickness of the path length encoding optical element described herein in the above-referenced Examples (3.1 mm BK7) may not be sufficient for OCT imaging in some tissues since the provide 800 m separation between individual subimages. Increasing the thickness of the BK7 glass to 7.7 mm may allow a path length separation of 2 mm. This thickness may be adequate for a free-space, hand-held OCT probes, but can be be problematic in small diameter, flexible catheters, where minimizing the rigid length can be important. In order to increase the optical thickness of the path length encoding element, a higher refractive index material such as silicon (12 = 3.5) may be used. To create a 2 mm delay with silicon, preferably approximately 1.6 mm of the material can be used. When using high refractive index glass, dispersion imbalances between the reference and sample arms should be considered. For high-resolution OCT imaging (0X/X > 10%), appropriate selection of the optical material used for path length encoding will depend on the center wavelength and bandwidth of the source.
Advantages of the exemplary embodiment of the method and apparatus according to the present invention may include the fact that the OCT frame rate is not increased, and the addition of only a single passive element in the OCT probe should be implemented. These features of ACPE make the system and and method of the present invention compatible with OCT imaging in internal organ systems in patients.
While implementation of ACPE may facilitate tradeoffs between speckle reduction and system sensitivity, the problems caused by speckle noise are likely more significant for clinical diagnosis than the penetration depth of modern OCT
systems, especially at 1300 nm. Since difficulties in interpreting features on the size scale of 20 m or less is in part a result of speckle noise in OCT images, ACPE would likely significantly improve the capabilities of OCT for the diagnosis of important diseases such as, but not limited to, dysplasia and inflammation in atherosclerosis.
Although only particular exemplary embodiments of the present invention have been described in detail herein above, those skilled in the art will readily appreciate and understand that many modifications are possible in the exemplary embodiments without materially departing from the novel teachings and advantages of this invention. Accordingly, all such modifications are intended to be included within the scope of the present invention as defined in the following claims.

Claims (10)

1. An apparatus irradiating a sample, comprising:

a) an interferometer forwarding an electromagnetic radiation; and b) a sample arm receiving the electromagnetic radiation, the sample arm including an arrangement which is configured to produce at least two radiations from the electromagnetic radiation so as to irradiate the sample, and to delay a first radiation of the at least two radiations with respect to a second radiation of the at least two radiations, wherein the delay of a path of the first radiation compared to a path of the second radiation is at least 500 m in air.
2. The apparatus according to claim 1, wherein the arrangement irradiates the sample by the first radiation at a first angle, and by the second radiation at a second angle, the first and second angles being different from one another.
3. The apparatus according to claim 2, wherein the first and second angles are different from one another as a function of the delay and at least one of a phase or an incident angle of each of the first and second radiations.
4. The apparatus according to claim 1, further comprising a detector which detects the first radiation, and forwards the detected energy to a processing arrangement.
5. The apparatus according to claim 1, further comprising an arrangement which includes two sections, each section being configured to delay a respective one of the radiations, and wherein a delay of the first radiation is greater than a delay of the second radiation.
6. The apparatus according to claim 1, wherein the delay of the path of the first radiation compared to the path of the second radiation is at least about 1 mm in air.
7. The apparatus according to claim 1, wherein the arrangement has an optical section with a refractive index of at least 3Ø
8. The apparatus according to claim 1, wherein the section comprises an anti-reflection-coated BK 7 glass.
9. The apparatus according to claim 8, wherein the glass has a thickness of from about 1.6 mm to about 7.7 mm.
10. The apparatus according to claim 1, wherein the first section comprises an anti-reflection-coated glass that has a refractive index of from about 1.51 to about 3.5.
CA2519937A 2003-03-31 2004-03-31 Speckle reduction in optical coherence tomography by path length encoded angular compounding Expired - Fee Related CA2519937C (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US45954303P 2003-03-31 2003-03-31
US60/459,543 2003-03-31
US47660003P 2003-06-06 2003-06-06
US60/476,600 2003-06-06
US51476903P 2003-10-27 2003-10-27
US60/514,769 2003-10-27
PCT/US2004/010152 WO2004088361A2 (en) 2003-03-31 2004-03-31 Speckle reduction in optical coherence tomography by path length encoded angular compounding

Publications (2)

Publication Number Publication Date
CA2519937A1 CA2519937A1 (en) 2004-10-14
CA2519937C true CA2519937C (en) 2012-11-20

Family

ID=33135983

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2519937A Expired - Fee Related CA2519937C (en) 2003-03-31 2004-03-31 Speckle reduction in optical coherence tomography by path length encoded angular compounding

Country Status (6)

Country Link
US (4) US7567349B2 (en)
EP (2) EP1611470B1 (en)
JP (2) JP4805142B2 (en)
AU (1) AU2004225188B2 (en)
CA (1) CA2519937C (en)
WO (1) WO2004088361A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11727534B2 (en) 2020-12-08 2023-08-15 International Business Machines Corporation Normalizing OCT image data

Families Citing this family (139)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE454845T1 (en) 2000-10-30 2010-01-15 Gen Hospital Corp OPTICAL SYSTEMS FOR TISSUE ANALYSIS
US9295391B1 (en) 2000-11-10 2016-03-29 The General Hospital Corporation Spectrally encoded miniature endoscopic imaging probe
EP2333523B1 (en) 2001-04-30 2020-04-08 The General Hospital Corporation Method and apparatus for improving image clarity and sensitivity in optical coherence tomography using dynamic feedback to control focal properties and coherence gating
DE10297689B4 (en) 2001-05-01 2007-10-18 The General Hospital Corp., Boston Method and device for the determination of atherosclerotic coating by measurement of optical tissue properties
US7355716B2 (en) 2002-01-24 2008-04-08 The General Hospital Corporation Apparatus and method for ranging and noise reduction of low coherence interferometry LCI and optical coherence tomography OCT signals by parallel detection of spectral bands
US8171567B1 (en) 2002-09-04 2012-05-01 Tracer Detection Technology Corp. Authentication method and system
EP1596716B1 (en) 2003-01-24 2014-04-30 The General Hospital Corporation System and method for identifying tissue using low-coherence interferometry
US7643153B2 (en) 2003-01-24 2010-01-05 The General Hospital Corporation Apparatus and method for ranging and noise reduction of low coherence interferometry LCI and optical coherence tomography OCT signals by parallel detection of spectral bands
EP1611470B1 (en) 2003-03-31 2015-10-14 The General Hospital Corporation Speckle reduction in optical coherence tomography by path length encoded angular compounding
EP2008579B1 (en) 2003-06-06 2016-11-09 The General Hospital Corporation Process and apparatus for a wavelength tuned light source
JP5567246B2 (en) 2003-10-27 2014-08-06 ザ ジェネラル ホスピタル コーポレイション Method and apparatus for performing optical imaging using frequency domain interferometry
RU2380750C2 (en) 2004-03-12 2010-01-27 Инджениа Текнолоджи Лимитед Methods and devices for creation of printing products with possibility of their identification and their subsequent verification
BRPI0508631A (en) 2004-03-12 2007-08-07 Ingenia Technology Ltd apparatus for determining a signature of an article arranged in a reading volume, use of the apparatus, methods for identifying an article made of paper or cardboard, an article made of plastic, a product by its packaging, a document, a garment or footwear, and a disc, method for tagging an article, and, tagged article
EP1754016B1 (en) 2004-05-29 2016-05-18 The General Hospital Corporation Process, system and software arrangement for a chromatic dispersion compensation using reflective layers in optical coherence tomography (oct) imaging
WO2006014392A1 (en) 2004-07-02 2006-02-09 The General Hospital Corporation Endoscopic imaging probe comprising dual clad fibre
EP1782020B1 (en) 2004-08-06 2012-10-03 The General Hospital Corporation Process, system and software arrangement for determining at least one location in a sample using an optical coherence tomography
GB2417592B (en) * 2004-08-13 2006-07-26 Ingenia Technology Ltd Authenticity verification of articles
ATE538714T1 (en) 2004-08-24 2012-01-15 Gen Hospital Corp METHOD, SYSTEM AND SOFTWARE ARRANGEMENT FOR DETERMINING THE ELASTIC MODULE
KR20070058523A (en) 2004-08-24 2007-06-08 더 제너럴 하스피탈 코포레이션 Method and apparatus for imaging of vessel segments
JP4997112B2 (en) 2004-09-29 2012-08-08 ザ ジェネラル ホスピタル コーポレイション Apparatus for transmitting at least one electromagnetic radiation and method of manufacturing the same
EP2278265A3 (en) 2004-11-24 2011-06-29 The General Hospital Corporation Common-Path Interferometer for Endoscopic OCT
EP1816949A1 (en) 2004-11-29 2007-08-15 The General Hospital Corporation Arrangements, devices, endoscopes, catheters and methods for performing optical imaging by simultaneously illuminating and detecting multiple points on a sample
ES2337497T3 (en) 2005-04-28 2010-04-26 The General Hospital Corporation EVALUATION OF CHARACTERISTICS OF THE IMAGE OF AN ANATOMICAL STRUCTURE IN IMAGES OF TOMOGRAPHY OF OPTICAL COHERENCE.
US20060294583A1 (en) * 2005-05-11 2006-12-28 Ingenia Holdings (U.K.) Limited Authenticity Verification
EP1887926B1 (en) 2005-05-31 2014-07-30 The General Hospital Corporation System and method which use spectral encoding heterodyne interferometry techniques for imaging
EP1889037A2 (en) * 2005-06-01 2008-02-20 The General Hospital Corporation Apparatus, method and system for performing phase-resolved optical frequency domain imaging
JP5123181B2 (en) * 2005-07-27 2013-01-16 インジェニア・テクノロジー・(ユーケイ)・リミテッド Authenticity verification
EP1908028A1 (en) * 2005-07-27 2008-04-09 Ingenia Technology Limited Authenticity verification
CN101238347B (en) 2005-08-09 2011-05-25 通用医疗公司 Apparatus, methods and storage medium for performing polarization-based quadrature demodulation in optical coherence tomography
GB2429950B (en) * 2005-09-08 2007-08-22 Ingenia Holdings Copying
WO2007034802A1 (en) * 2005-09-20 2007-03-29 Sumitomo Electric Industries, Ltd. Elasticity/viscosity measuring device
CN101304683B (en) 2005-09-29 2012-12-12 通用医疗公司 Method and apparatus for method for viewing and analyzing of one or more biological samples with progressively increasing resolutions
WO2007047690A1 (en) 2005-10-14 2007-04-26 The General Hospital Corporation Spectral- and frequency- encoded fluorescence imaging
EP1969525A1 (en) * 2005-12-23 2008-09-17 Ingenia Holdings (UK)Limited Optical authentication
EP1971848B1 (en) 2006-01-10 2019-12-04 The General Hospital Corporation Systems and methods for generating data based on one or more spectrally-encoded endoscopy techniques
GB2434442A (en) * 2006-01-16 2007-07-25 Ingenia Holdings Verification of performance attributes of packaged integrated circuits
US9087368B2 (en) 2006-01-19 2015-07-21 The General Hospital Corporation Methods and systems for optical imaging or epithelial luminal organs by beam scanning thereof
US8145018B2 (en) 2006-01-19 2012-03-27 The General Hospital Corporation Apparatus for obtaining information for a structure using spectrally-encoded endoscopy techniques and methods for producing one or more optical arrangements
JP3992064B2 (en) * 2006-01-20 2007-10-17 住友電気工業株式会社 Optical analyzer
CN101370426A (en) * 2006-01-20 2009-02-18 通用医疗公司 Systems, arrangement and process for providing speckle reductions using a wave front modulation for optical coherence tomography
WO2007149602A2 (en) 2006-02-01 2007-12-27 The General Hospital Corporation Methods and systems for providing electromagnetic radiation to at least one portion of a sample using conformal laser therapy procedures
US9186066B2 (en) 2006-02-01 2015-11-17 The General Hospital Corporation Apparatus for applying a plurality of electro-magnetic radiations to a sample
JP5519152B2 (en) 2006-02-08 2014-06-11 ザ ジェネラル ホスピタル コーポレイション Device for acquiring information about anatomical samples using optical microscopy
GB2435322A (en) 2006-02-15 2007-08-22 Oti Ophthalmic Technologies Measuring curvature or axial position using OCT
US7982879B2 (en) 2006-02-24 2011-07-19 The General Hospital Corporation Methods and systems for performing angle-resolved fourier-domain optical coherence tomography
EP2004041B1 (en) 2006-04-05 2013-11-06 The General Hospital Corporation Methods, arrangements and systems for polarization-sensitive optical frequency domain imaging of a sample
JP2009536740A (en) 2006-05-10 2009-10-15 ザ ジェネラル ホスピタル コーポレイション Process, configuration and system for providing frequency domain imaging of samples
WO2007133964A2 (en) 2006-05-12 2007-11-22 The General Hospital Corporation Processes, arrangements and systems for providing a fiber layer thickness map based on optical coherence tomography images
JP2007309881A (en) * 2006-05-22 2007-11-29 Fujifilm Corp Wavelength sweeping light source, and optical tomographic imaging device
JP2007309882A (en) * 2006-05-22 2007-11-29 Fujifilm Corp Wavelength sweeping light source, and optical tomographic imaging device
GB2440386A (en) * 2006-06-12 2008-01-30 Ingenia Technology Ltd Scanner authentication
JP2010501877A (en) 2006-08-25 2010-01-21 ザ ジェネラル ホスピタル コーポレイション Apparatus and method for improving optical coherence tomography imaging capabilities using volumetric filtering techniques
US8838213B2 (en) 2006-10-19 2014-09-16 The General Hospital Corporation Apparatus and method for obtaining and providing imaging information associated with at least one portion of a sample, and effecting such portion(s)
JP5406427B2 (en) * 2006-11-17 2014-02-05 株式会社トプコン Tomographic image processing method, apparatus and program, and optical tomographic imaging system using the same
EP2662674A3 (en) 2007-01-19 2014-06-25 The General Hospital Corporation Rotating disk reflection for fast wavelength scanning of dispersed broadbend light
WO2008118781A2 (en) 2007-03-23 2008-10-02 The General Hospital Corporation Methods, arrangements and apparatus for utilizing a wavelength-swept laser using angular scanning and dispersion procedures
JP5523658B2 (en) * 2007-03-23 2014-06-18 株式会社トプコン Optical image measuring device
US10534129B2 (en) 2007-03-30 2020-01-14 The General Hospital Corporation System and method providing intracoronary laser speckle imaging for the detection of vulnerable plaque
US8045177B2 (en) 2007-04-17 2011-10-25 The General Hospital Corporation Apparatus and methods for measuring vibrations using spectrally-encoded endoscopy
US8115919B2 (en) 2007-05-04 2012-02-14 The General Hospital Corporation Methods, arrangements and systems for obtaining information associated with a sample using optical microscopy
KR100906800B1 (en) 2007-06-21 2009-07-09 삼성전기주식회사 Apparatus and method for speckle suppression in display system using optical modulator
WO2009018456A2 (en) 2007-07-31 2009-02-05 The General Hospital Corporation Systems and methods for providing beam scan patterns for high speed doppler optical frequency domain imaging
US8040608B2 (en) 2007-08-31 2011-10-18 The General Hospital Corporation System and method for self-interference fluorescence microscopy, and computer-accessible medium associated therewith
WO2009039303A1 (en) * 2007-09-19 2009-03-26 State University Of New York At Stony Brook Optical coherence tomography systems and methods
US7933021B2 (en) 2007-10-30 2011-04-26 The General Hospital Corporation System and method for cladding mode detection
US7878651B2 (en) * 2007-12-26 2011-02-01 Carl Zeiss Meditec, Inc. Refractive prescription using optical coherence tomography
US9332942B2 (en) 2008-01-28 2016-05-10 The General Hospital Corporation Systems, processes and computer-accessible medium for providing hybrid flourescence and optical coherence tomography imaging
US11123047B2 (en) 2008-01-28 2021-09-21 The General Hospital Corporation Hybrid systems and methods for multi-modal acquisition of intravascular imaging data and counteracting the effects of signal absorption in blood
EP2274572A4 (en) 2008-05-07 2013-08-28 Gen Hospital Corp System, method and computer-accessible medium for tracking vessel motion during three-dimensional coronary artery microscopy
JP5795531B2 (en) 2008-06-20 2015-10-14 ザ ジェネラル ホスピタル コーポレイション Fused fiber optic coupler structure and method of using the same
US9254089B2 (en) 2008-07-14 2016-02-09 The General Hospital Corporation Apparatus and methods for facilitating at least partial overlap of dispersed ration on at least one sample
WO2010009144A2 (en) * 2008-07-14 2010-01-21 The General Hospital Corporation Apparatus configured to provide a wavelength-swept electro-mangnetic radiation
US7859654B2 (en) * 2008-07-17 2010-12-28 Schlumberger Technology Corporation Frequency-scanned optical time domain reflectometry
JP5731394B2 (en) 2008-12-10 2015-06-10 ザ ジェネラル ホスピタル コーポレイション System, apparatus and method for extending imaging depth range of optical coherence tomography through optical subsampling
GB2466465B (en) * 2008-12-19 2011-02-16 Ingenia Holdings Authentication
GB2466311B (en) 2008-12-19 2010-11-03 Ingenia Holdings Self-calibration of a matching algorithm for determining authenticity
JP5373389B2 (en) 2008-12-26 2013-12-18 カール ツァイス メディテック インコーポレイテッド Optical structure information acquisition apparatus and optical interference signal processing method thereof
JP5479047B2 (en) * 2008-12-26 2014-04-23 キヤノン株式会社 Imaging apparatus and imaging method
US8097864B2 (en) 2009-01-26 2012-01-17 The General Hospital Corporation System, method and computer-accessible medium for providing wide-field superresolution microscopy
CA2749670A1 (en) 2009-02-04 2010-08-12 The General Hospital Corporation Apparatus and method for utilization of a high-speed optical wavelength tuning source
WO2010105197A2 (en) 2009-03-12 2010-09-16 The General Hospital Corporation Non-contact optical system, computer-accessible medium and method for measuring at least one mechanical property of tissue using coherent speckle techniques(s)
US20100241058A1 (en) * 2009-03-19 2010-09-23 Ahmed Syed Yosuf Oct guided tissue ablation
CN102415099B (en) * 2009-04-22 2014-04-30 惠普开发有限公司 Spatially-varying spectral response calibration data
CN102469943A (en) 2009-07-14 2012-05-23 通用医疗公司 Apparatus, systems and methods for measuring flow and pressure within a vessel
DE102009045075A1 (en) * 2009-09-28 2011-04-07 Carl Zeiss Ag Nanostructured filling material dispersion condition e.g. sample agglomeration, measuring device for dispersion production or preparation device, has processing unit detecting measured variable assigned to condition of filling material
GB2476226B (en) 2009-11-10 2012-03-28 Ingenia Holdings Ltd Optimisation
HUE052561T2 (en) 2010-03-05 2021-05-28 Massachusetts Gen Hospital Apparatus for providing electro-magnetic radiation to a sample
CN101836854B (en) * 2010-03-11 2011-09-07 深圳市斯尔顿科技有限公司 Ophthalmic optical coherence tomography device and method
US9069130B2 (en) 2010-05-03 2015-06-30 The General Hospital Corporation Apparatus, method and system for generating optical radiation from biological gain media
JP5778762B2 (en) 2010-05-25 2015-09-16 ザ ジェネラル ホスピタル コーポレイション Apparatus and method for spectral analysis of optical coherence tomography images
US9557154B2 (en) 2010-05-25 2017-01-31 The General Hospital Corporation Systems, devices, methods, apparatus and computer-accessible media for providing optical imaging of structures and compositions
EP2575591A4 (en) 2010-06-03 2017-09-13 The General Hospital Corporation Apparatus and method for devices for imaging structures in or at one or more luminal organs
EP2632324A4 (en) 2010-10-27 2015-04-22 Gen Hospital Corp Apparatus, systems and methods for measuring blood pressure within at least one vessel
US9025160B2 (en) * 2011-01-28 2015-05-05 The Regents Of The University Of Colorado, A Body Corporate Spectral phase analysis for precision ranging
WO2012149175A1 (en) 2011-04-29 2012-11-01 The General Hospital Corporation Means for determining depth-resolved physical and/or optical properties of scattering media
US8655431B2 (en) 2011-05-31 2014-02-18 Vanderbilt University Apparatus and method for real-time imaging and monitoring of an electrosurgical procedure
US9757038B2 (en) 2011-05-31 2017-09-12 Vanderbilt University Optical coherence tomography probe
US9330092B2 (en) 2011-07-19 2016-05-03 The General Hospital Corporation Systems, methods, apparatus and computer-accessible-medium for providing polarization-mode dispersion compensation in optical coherence tomography
CN103858134A (en) * 2011-08-09 2014-06-11 光视有限公司 Motion correction and normalization of features in optical coherence tomography
US10241028B2 (en) 2011-08-25 2019-03-26 The General Hospital Corporation Methods, systems, arrangements and computer-accessible medium for providing micro-optical coherence tomography procedures
EP2769491A4 (en) 2011-10-18 2015-07-22 Gen Hospital Corp Apparatus and methods for producing and/or providing recirculating optical delay(s)
JP6025349B2 (en) * 2012-03-08 2016-11-16 キヤノン株式会社 Image processing apparatus, optical coherence tomography apparatus, image processing method, and optical coherence tomography method
EP2833776A4 (en) 2012-03-30 2015-12-09 Gen Hospital Corp Imaging system, method and distal attachment for multidirectional field of view endoscopy
US11490797B2 (en) 2012-05-21 2022-11-08 The General Hospital Corporation Apparatus, device and method for capsule microscopy
US9541375B2 (en) 2012-07-20 2017-01-10 Samsung Electronics Co., Ltd. Method and apparatus for generating tomography images
US9639915B2 (en) 2012-08-08 2017-05-02 Samsung Electronics Co., Ltd. Image processing method and apparatus
WO2014031748A1 (en) 2012-08-22 2014-02-27 The General Hospital Corporation System, method, and computer-accessible medium for fabrication minature endoscope using soft lithography
WO2014085911A1 (en) 2012-12-05 2014-06-12 Tornado Medical Systems, Inc. System and method for wide field oct imaging
KR102025756B1 (en) 2013-01-04 2019-09-27 삼성전자주식회사 Method, Apparatus and system for reducing speckles on image
US10893806B2 (en) 2013-01-29 2021-01-19 The General Hospital Corporation Apparatus, systems and methods for providing information regarding the aortic valve
US9655521B2 (en) * 2013-01-31 2017-05-23 Physical Sciences, Inc. Combined reflectance confocal microscopy-optical coherence tomography system for imaging of biological tissue
US11179028B2 (en) 2013-02-01 2021-11-23 The General Hospital Corporation Objective lens arrangement for confocal endomicroscopy
CA2906425A1 (en) 2013-03-15 2014-09-25 Amo Wavefront Sciences, Llc Angular multiplexed optical coherence tomography systems and methods
JP6378311B2 (en) 2013-03-15 2018-08-22 ザ ジェネラル ホスピタル コーポレイション Methods and systems for characterizing objects
US9784681B2 (en) 2013-05-13 2017-10-10 The General Hospital Corporation System and method for efficient detection of the phase and amplitude of a periodic modulation associated with self-interfering fluorescence
US9349174B2 (en) 2013-05-31 2016-05-24 Microsoft Technology Licensing, Llc Absolute phase measurement with secondary pattern-embedded fringe
EP3692887B1 (en) 2013-07-19 2024-03-06 The General Hospital Corporation Imaging apparatus which utilizes multidirectional field of view endoscopy
WO2015010133A1 (en) 2013-07-19 2015-01-22 The General Hospital Corporation Determining eye motion by imaging retina. with feedback
EP3910282B1 (en) 2013-07-26 2024-01-17 The General Hospital Corporation Method of providing a laser radiation with a laser arrangement utilizing optical dispersion for applications in fourier-domain optical coherence tomography
US9116854B2 (en) * 2013-10-02 2015-08-25 National Applied Research Laboratories Method of evaluating image correlation with speckle patter
US9733460B2 (en) 2014-01-08 2017-08-15 The General Hospital Corporation Method and apparatus for microscopic imaging
US10736494B2 (en) 2014-01-31 2020-08-11 The General Hospital Corporation System and method for facilitating manual and/or automatic volumetric imaging with real-time tension or force feedback using a tethered imaging device
WO2015153982A1 (en) 2014-04-04 2015-10-08 The General Hospital Corporation Apparatus and method for controlling propagation and/or transmission of electromagnetic radiation in flexible waveguide(s)
ES2907287T3 (en) 2014-07-25 2022-04-22 Massachusetts Gen Hospital Apparatus for imaging and in vivo diagnosis
EP3230685B1 (en) 2014-12-14 2022-04-27 Cylite Pty Ltd Multichannel optical receivers
WO2016127039A2 (en) 2015-02-06 2016-08-11 The Board Of Trustees Of The Leland Stanford Junior University High-resolution optical molecular imaging systems, compositions, and methods
JP2016151524A (en) * 2015-02-18 2016-08-22 ソニー株式会社 Speckle imaging device, speckle imaging system, and speckle imaging method
US11278206B2 (en) 2015-04-16 2022-03-22 Gentuity, Llc Micro-optic probes for neurology
JP2016217860A (en) * 2015-05-20 2016-12-22 キヤノン株式会社 Control device, measuring device, control method, program, and storage medium
US10542961B2 (en) 2015-06-15 2020-01-28 The Research Foundation For The State University Of New York System and method for infrasonic cardiac monitoring
US10631718B2 (en) 2015-08-31 2020-04-28 Gentuity, Llc Imaging system includes imaging probe and delivery devices
US20180299251A1 (en) * 2015-10-19 2018-10-18 The Board Of Trustees Of The Leland Stanford Junior University Methods and apparatus for speckle-free optical coherence imaging
TWI568408B (en) * 2015-12-23 2017-02-01 財團法人工業技術研究院 Intraocular pressure detecting device and detecting method thereof
JP6766995B2 (en) * 2016-11-09 2020-10-14 株式会社ミツトヨ Phase shift interferometer
EP3655748B1 (en) 2017-07-18 2023-08-09 Perimeter Medical Imaging, Inc. Sample container for stabilizing and aligning excised biological tissue samples for ex vivo analysis
WO2019108598A1 (en) 2017-11-28 2019-06-06 Gentuity, Llc Imaging system
RU2679947C1 (en) * 2017-12-13 2019-02-14 Федеральное государственное бюджетное образовательное учреждение высшего образования "Тамбовский государственный технический университет" (ФГБОУ ВО "ТГТУ") Method for obtaining structural images in endoscopic optical coherent tomography
US10732100B2 (en) * 2018-06-29 2020-08-04 L'oreal Systems and methods for predicting sun protection factor of sunscreen formulations in vitro
WO2022029904A1 (en) * 2020-08-05 2022-02-10 三菱電機株式会社 Distance measurement device, distance measurement method, and radar device

Family Cites Families (608)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US617286A (en) * 1899-01-03 galland
US291277A (en) * 1884-01-01 Drag-saw
US126048A (en) * 1872-04-23 Improvement in printing-telegraphs
US239938A (en) * 1881-04-12 orofford
US19208A (en) * 1858-01-26 Padlock
US46837A (en) * 1865-03-14 Improvement in the manufacture of felted fabrics
US728440A (en) * 1902-10-16 1903-05-19 Standard Water Purifying Company Purifying apparatus.
US2339754A (en) * 1941-03-04 1944-01-25 Westinghouse Electric & Mfg Co Supervisory apparatus
US3028114A (en) * 1959-09-21 1962-04-03 Kloeckner Werke Ag Arrangement for coiling metal strip material
US3090753A (en) * 1960-08-02 1963-05-21 Exxon Research Engineering Co Ester oil compositions containing acid anhydride
GB1257778A (en) 1967-12-07 1971-12-22
US3601480A (en) 1968-07-10 1971-08-24 Physics Int Co Optical tunnel high-speed camera system
JPS4932484U (en) 1972-06-19 1974-03-20
US3872407A (en) * 1972-09-01 1975-03-18 Us Navy Rapidly tunable laser
JPS584481Y2 (en) * 1973-06-23 1983-01-26 オリンパス光学工業株式会社 Naishikiyoushiyahenkankogakkei
FR2253410A5 (en) 1973-12-03 1975-06-27 Inst Nat Sante Rech Med
US4077949A (en) * 1973-12-28 1978-03-07 Sloan-Kettering Institute For Cancer Research Polypeptide hormones of the thymus
US3941121A (en) 1974-12-20 1976-03-02 The University Of Cincinnati Focusing fiber-optic needle endoscope
US3983507A (en) 1975-01-06 1976-09-28 Research Corporation Tunable laser systems and method
US3973219A (en) 1975-04-24 1976-08-03 Cornell Research Foundation, Inc. Very rapidly tuned cw dye laser
US4030831A (en) 1976-03-22 1977-06-21 The United States Of America As Represented By The Secretary Of The Navy Phase detector for optical figure sensing
US4072200A (en) * 1976-05-12 1978-02-07 Morris Fred J Surveying of subterranean magnetic bodies from an adjacent off-vertical borehole
US4141362A (en) 1977-05-23 1979-02-27 Richard Wolf Gmbh Laser endoscope
US4224929A (en) 1977-11-08 1980-09-30 Olympus Optical Co., Ltd. Endoscope with expansible cuff member and operation section
DE2964775D1 (en) 1978-03-09 1983-03-24 Nat Res Dev Measurement of small movements
GB2030313A (en) 1978-06-29 1980-04-02 Wolf Gmbh Richard Endoscopes
FR2448728A1 (en) 1979-02-07 1980-09-05 Thomson Csf ROTATING JOINT DEVICE FOR OPTICAL CONDUCTOR CONNECTION AND SYSTEM COMPRISING SUCH A DEVICE
US4263843A (en) * 1979-07-30 1981-04-28 Aluminum Company Of America Method and apparatus for controlled removal of excess slurry from organic foam
US4300816A (en) 1979-08-30 1981-11-17 United Technologies Corporation Wide band multicore optical fiber
US4295738A (en) 1979-08-30 1981-10-20 United Technologies Corporation Fiber optic strain sensor
US4428643A (en) * 1981-04-08 1984-01-31 Xerox Corporation Optical scanning system with wavelength shift correction
US5065331A (en) 1981-05-18 1991-11-12 Vachon Reginald I Apparatus and method for determining the stress and strain in pipes, pressure vessels, structural members and other deformable bodies
GB2106736B (en) 1981-09-03 1985-06-12 Standard Telephones Cables Ltd Optical transmission system
US4479499A (en) 1982-01-29 1984-10-30 Alfano Robert R Method and apparatus for detecting the presence of caries in teeth using visible light
US5302025A (en) 1982-08-06 1994-04-12 Kleinerman Marcos Y Optical systems for sensing temperature and other physical parameters
US4601036A (en) 1982-09-30 1986-07-15 Honeywell Inc. Rapidly tunable laser
HU187188B (en) 1982-11-25 1985-11-28 Koezponti Elelmiszeripari Device for generating radiation of controllable spectral structure
CH663466A5 (en) * 1983-09-12 1987-12-15 Battelle Memorial Institute METHOD AND DEVICE FOR DETERMINING THE POSITION OF AN OBJECT IN RELATION TO A REFERENCE.
US4639999A (en) 1984-11-02 1987-02-03 Xerox Corporation High resolution, high efficiency I.R. LED printing array fabrication method
US4763977A (en) 1985-01-09 1988-08-16 Canadian Patents And Development Limited-Societe Optical fiber coupler with tunable coupling ratio and method of making
US5318024A (en) 1985-03-22 1994-06-07 Massachusetts Institute Of Technology Laser endoscope for spectroscopic imaging
EP0590268B1 (en) 1985-03-22 1998-07-01 Massachusetts Institute Of Technology Fiber Optic Probe System for Spectrally Diagnosing Tissue
US4734578A (en) 1985-03-27 1988-03-29 Olympus Optical Co., Ltd. Two-dimensional scanning photo-electric microscope
US4607622A (en) 1985-04-11 1986-08-26 Charles D. Fritch Fiber optic ocular endoscope
US4631498A (en) 1985-04-26 1986-12-23 Hewlett-Packard Company CW Laser wavemeter/frequency locking technique
US4650327A (en) * 1985-10-28 1987-03-17 Oximetrix, Inc. Optical catheter calibrating assembly
JPS62188001U (en) 1986-05-20 1987-11-30
US5040889A (en) 1986-05-30 1991-08-20 Pacific Scientific Company Spectrometer with combined visible and ultraviolet sample illumination
CA1290019C (en) 1986-06-20 1991-10-01 Hideo Kuwahara Dual balanced optical signal receiver
US4770492A (en) 1986-10-28 1988-09-13 Spectran Corporation Pressure or strain sensitive optical fiber
JPH0824665B2 (en) 1986-11-28 1996-03-13 オリンパス光学工業株式会社 Endoscope device
US4744656A (en) * 1986-12-08 1988-05-17 Spectramed, Inc. Disposable calibration boot for optical-type cardiovascular catheter
JPS63158363A (en) 1986-12-22 1988-07-01 Daikin Mfg Co Ltd Seal device for air rotary joint
US4751706A (en) 1986-12-31 1988-06-14 The United States Of America As Represented By The Secretary Of The Army Laser for providing rapid sequence of different wavelengths
US4834111A (en) * 1987-01-12 1989-05-30 The Trustees Of Columbia University In The City Of New York Heterodyne interferometer
CA1339426C (en) 1987-09-01 1997-09-02 Michael R. Layton Hydrophone demodulator circuit and method
US5202931A (en) 1987-10-06 1993-04-13 Cell Analysis Systems, Inc. Methods and apparatus for the quantitation of nuclear protein
US4909631A (en) * 1987-12-18 1990-03-20 Tan Raul Y Method for film thickness and refractive index determination
US4890901A (en) * 1987-12-22 1990-01-02 Hughes Aircraft Company Color corrector for embedded prisms
US4892406A (en) * 1988-01-11 1990-01-09 United Technologies Corporation Method of and arrangement for measuring vibrations
FR2626367B1 (en) * 1988-01-25 1990-05-11 Thomson Csf MULTI-POINT FIBER OPTIC TEMPERATURE SENSOR
FR2626383B1 (en) 1988-01-27 1991-10-25 Commissariat Energie Atomique EXTENDED FIELD SCAN AND DEPTH CONFOCAL OPTICAL MICROSCOPY AND DEVICES FOR CARRYING OUT THE METHOD
US4925302A (en) * 1988-04-13 1990-05-15 Hewlett-Packard Company Frequency locking device
US4998972A (en) 1988-04-28 1991-03-12 Thomas J. Fogarty Real time angioscopy imaging system
US5730731A (en) 1988-04-28 1998-03-24 Thomas J. Fogarty Pressure-based irrigation accumulator
US4905169A (en) 1988-06-02 1990-02-27 The United States Of America As Represented By The United States Department Of Energy Method and apparatus for simultaneously measuring a plurality of spectral wavelengths present in electromagnetic radiation
US5242437A (en) 1988-06-10 1993-09-07 Trimedyne Laser Systems, Inc. Medical device applying localized high intensity light and heat, particularly for destruction of the endometrium
EP0393165B2 (en) 1988-07-13 2007-07-25 Optiscan Pty Ltd Scanning confocal endoscope
GB8817672D0 (en) 1988-07-25 1988-09-01 Sira Ltd Optical apparatus
US5214538A (en) * 1988-07-25 1993-05-25 Keymed (Medical And Industrial Equipment) Limited Optical apparatus
US4868834A (en) 1988-09-14 1989-09-19 The United States Of America As Represented By The Secretary Of The Army System for rapidly tuning a low pressure pulsed laser
DE3833602A1 (en) * 1988-10-03 1990-02-15 Krupp Gmbh SPECTROMETER FOR SIMULTANEOUS INTENSITY MEASUREMENT IN DIFFERENT SPECTRAL AREAS
US4940328A (en) 1988-11-04 1990-07-10 Georgia Tech Research Corporation Optical sensing apparatus and method
US4966589A (en) 1988-11-14 1990-10-30 Hemedix International, Inc. Intravenous catheter placement device
US5419323A (en) * 1988-12-21 1995-05-30 Massachusetts Institute Of Technology Method for laser induced fluorescence of tissue
US5046501A (en) 1989-01-18 1991-09-10 Wayne State University Atherosclerotic identification
US5085496A (en) * 1989-03-31 1992-02-04 Sharp Kabushiki Kaisha Optical element and optical pickup device comprising it
US5317389A (en) * 1989-06-12 1994-05-31 California Institute Of Technology Method and apparatus for white-light dispersed-fringe interferometric measurement of corneal topography
US4965599A (en) 1989-11-13 1990-10-23 Eastman Kodak Company Scanning apparatus for halftone image screen writing
US5133035A (en) 1989-11-14 1992-07-21 Hicks John W Multifiber endoscope with multiple scanning modes to produce an image free of fixed pattern noise
US4984888A (en) 1989-12-13 1991-01-15 Imo Industries, Inc. Two-dimensional spectrometer
KR930003307B1 (en) * 1989-12-14 1993-04-24 주식회사 금성사 Three dimensional projector
US5251009A (en) 1990-01-22 1993-10-05 Ciba-Geigy Corporation Interferometric measuring arrangement for refractive index measurements in capillary tubes
DD293205B5 (en) 1990-03-05 1995-06-29 Zeiss Carl Jena Gmbh Optical fiber guide for a medical observation device
US5039193A (en) 1990-04-03 1991-08-13 Focal Technologies Incorporated Fibre optic single mode rotary joint
US5262644A (en) 1990-06-29 1993-11-16 Southwest Research Institute Remote spectroscopy for raman and brillouin scattering
US5197470A (en) * 1990-07-16 1993-03-30 Eastman Kodak Company Near infrared diagnostic method and instrument
GB9015793D0 (en) 1990-07-18 1990-09-05 Medical Res Council Confocal scanning optical microscope
US5127730A (en) 1990-08-10 1992-07-07 Regents Of The University Of Minnesota Multi-color laser scanning confocal imaging system
US5845639A (en) 1990-08-10 1998-12-08 Board Of Regents Of The University Of Washington Optical imaging methods
US5305759A (en) * 1990-09-26 1994-04-26 Olympus Optical Co., Ltd. Examined body interior information observing apparatus by using photo-pulses controlling gains for depths
US5241364A (en) 1990-10-19 1993-08-31 Fuji Photo Film Co., Ltd. Confocal scanning type of phase contrast microscope and scanning microscope
US5250186A (en) 1990-10-23 1993-10-05 Cetus Corporation HPLC light scattering detector for biopolymers
US5202745A (en) * 1990-11-07 1993-04-13 Hewlett-Packard Company Polarization independent optical coherence-domain reflectometry
US5275594A (en) 1990-11-09 1994-01-04 C. R. Bard, Inc. Angioplasty system having means for identification of atherosclerotic plaque
JP3035336B2 (en) * 1990-11-27 2000-04-24 興和株式会社 Blood flow measurement device
US5228001A (en) 1991-01-23 1993-07-13 Syracuse University Optical random access memory
US5784162A (en) 1993-08-18 1998-07-21 Applied Spectral Imaging Ltd. Spectral bio-imaging methods for biological research, medical diagnostics and therapy
US6198532B1 (en) 1991-02-22 2001-03-06 Applied Spectral Imaging Ltd. Spectral bio-imaging of the eye
US5293872A (en) * 1991-04-03 1994-03-15 Alfano Robert R Method for distinguishing between calcified atherosclerotic tissue and fibrous atherosclerotic tissue or normal cardiovascular tissue using Raman spectroscopy
US5321501A (en) 1991-04-29 1994-06-14 Massachusetts Institute Of Technology Method and apparatus for optical imaging with means for controlling the longitudinal range of the sample
US6134003A (en) 1991-04-29 2000-10-17 Massachusetts Institute Of Technology Method and apparatus for performing optical measurements using a fiber optic imaging guidewire, catheter or endoscope
US5956355A (en) 1991-04-29 1999-09-21 Massachusetts Institute Of Technology Method and apparatus for performing optical measurements using a rapidly frequency-tuned laser
US6111645A (en) 1991-04-29 2000-08-29 Massachusetts Institute Of Technology Grating based phase control optical delay line
US6501551B1 (en) 1991-04-29 2002-12-31 Massachusetts Institute Of Technology Fiber optic imaging endoscope interferometer with at least one faraday rotator
US5465147A (en) 1991-04-29 1995-11-07 Massachusetts Institute Of Technology Method and apparatus for acquiring images using a ccd detector array and no transverse scanner
US6564087B1 (en) 1991-04-29 2003-05-13 Massachusetts Institute Of Technology Fiber optic needle probes for optical coherence tomography imaging
US6485413B1 (en) 1991-04-29 2002-11-26 The General Hospital Corporation Methods and apparatus for forward-directed optical scanning instruments
US5748598A (en) * 1995-12-22 1998-05-05 Massachusetts Institute Of Technology Apparatus and methods for reading multilayer storage media using short coherence length sources
US5441053A (en) 1991-05-03 1995-08-15 University Of Kentucky Research Foundation Apparatus and method for multiple wavelength of tissue
US5281811A (en) 1991-06-17 1994-01-25 Litton Systems, Inc. Digital wavelength division multiplex optical transducer having an improved decoder
US5208651A (en) 1991-07-16 1993-05-04 The Regents Of The University Of California Apparatus and method for measuring fluorescence intensities at a plurality of wavelengths and lifetimes
WO1993003672A1 (en) 1991-08-20 1993-03-04 Redd Douglas C B Optical histochemical analysis, in vivo detection and real-time guidance for ablation of abnormal tissues using a raman spectroscopic detection system
DE4128744C1 (en) * 1991-08-29 1993-04-22 Siemens Ag, 8000 Muenchen, De
EP0550929B1 (en) 1991-12-30 1997-03-19 Koninklijke Philips Electronics N.V. Optical device and apparatus for scanning an information plane, comprising such an optical device
US5353790A (en) 1992-01-17 1994-10-11 Board Of Regents, The University Of Texas System Method and apparatus for optical measurement of bilirubin in tissue
US5212667A (en) * 1992-02-03 1993-05-18 General Electric Company Light imaging in a scattering medium, using ultrasonic probing and speckle image differencing
US5217456A (en) 1992-02-24 1993-06-08 Pdt Cardiovascular, Inc. Device and method for intra-vascular optical radial imaging
US5283795A (en) 1992-04-21 1994-02-01 Hughes Aircraft Company Diffraction grating driven linear frequency chirped laser
US5248876A (en) 1992-04-21 1993-09-28 International Business Machines Corporation Tandem linear scanning confocal imaging system with focal volumes at different heights
US5486701A (en) * 1992-06-16 1996-01-23 Prometrix Corporation Method and apparatus for measuring reflectance in two wavelength bands to enable determination of thin film thickness
US5716324A (en) 1992-08-25 1998-02-10 Fuji Photo Film Co., Ltd. Endoscope with surface and deep portion imaging systems
US5348003A (en) 1992-09-03 1994-09-20 Sirraya, Inc. Method and apparatus for chemical analysis
US5772597A (en) 1992-09-14 1998-06-30 Sextant Medical Corporation Surgical tool end effector
US5698397A (en) 1995-06-07 1997-12-16 Sri International Up-converting reporters for biological and other assays using laser excitation techniques
AU5672194A (en) * 1992-11-18 1994-06-22 Spectrascience, Inc. Apparatus for diagnostic imaging
US5383467A (en) * 1992-11-18 1995-01-24 Spectrascience, Inc. Guidewire catheter and apparatus for diagnostic imaging
US5785663A (en) 1992-12-21 1998-07-28 Artann Corporation Method and device for mechanical imaging of prostate
US5400771A (en) 1993-01-21 1995-03-28 Pirak; Leon Endotracheal intubation assembly and related method
JPH06222242A (en) 1993-01-27 1994-08-12 Shin Etsu Chem Co Ltd Optical fiber coupler and its manufacture
US5987346A (en) 1993-02-26 1999-11-16 Benaron; David A. Device and method for classification of tissue
US5414509A (en) 1993-03-08 1995-05-09 Associated Universities, Inc. Optical pressure/density measuring means
JP3112595B2 (en) 1993-03-17 2000-11-27 安藤電気株式会社 Optical fiber strain position measuring device using optical frequency shifter
FI93781C (en) 1993-03-18 1995-05-26 Wallac Oy Biospecific multiparametric assay method
DE4309056B4 (en) 1993-03-20 2006-05-24 Häusler, Gerd, Prof. Dr. Method and device for determining the distance and scattering intensity of scattering points
US5485079A (en) * 1993-03-29 1996-01-16 Matsushita Electric Industrial Co., Ltd. Magneto-optical element and optical magnetic field sensor
DE4310209C2 (en) * 1993-03-29 1996-05-30 Bruker Medizintech Optical stationary imaging in strongly scattering media
DE4314189C1 (en) * 1993-04-30 1994-11-03 Bodenseewerk Geraetetech Device for the examination of optical fibres made of glass by means of heterodyne Brillouin spectroscopy
US5424827A (en) 1993-04-30 1995-06-13 Litton Systems, Inc. Optical system and method for eliminating overlap of diffraction spectra
SE501932C2 (en) 1993-04-30 1995-06-26 Ericsson Telefon Ab L M Apparatus and method for dispersion compensation in a fiber optic transmission system
US5454807A (en) 1993-05-14 1995-10-03 Boston Scientific Corporation Medical treatment of deeply seated tissue using optical radiation
DE69418248T2 (en) 1993-06-03 1999-10-14 Hamamatsu Photonics Kk Optical laser scanning system with Axikon
JP3234353B2 (en) 1993-06-15 2001-12-04 富士写真フイルム株式会社 Tomographic information reader
US5840031A (en) 1993-07-01 1998-11-24 Boston Scientific Corporation Catheters for imaging, sensing electrical potentials and ablating tissue
US5995645A (en) 1993-08-18 1999-11-30 Applied Spectral Imaging Ltd. Method of cancer cell detection
US5803082A (en) 1993-11-09 1998-09-08 Staplevision Inc. Omnispectramammography
US5983125A (en) 1993-12-13 1999-11-09 The Research Foundation Of City College Of New York Method and apparatus for in vivo examination of subcutaneous tissues inside an organ of a body using optical spectroscopy
US5450203A (en) 1993-12-22 1995-09-12 Electroglas, Inc. Method and apparatus for determining an objects position, topography and for imaging
US5411016A (en) 1994-02-22 1995-05-02 Scimed Life Systems, Inc. Intravascular balloon catheter for use in combination with an angioscope
US5590660A (en) * 1994-03-28 1997-01-07 Xillix Technologies Corp. Apparatus and method for imaging diseased tissue using integrated autofluorescence
DE4411017C2 (en) * 1994-03-30 1995-06-08 Alexander Dr Knuettel Optical stationary spectroscopic imaging in strongly scattering objects through special light focusing and signal detection of light of different wavelengths
TW275570B (en) * 1994-05-05 1996-05-11 Boehringer Mannheim Gmbh
ATE242999T1 (en) 1994-07-14 2003-07-15 Washington Res Found DEVICE FOR DETECTING BARRETT METAPLASIA IN THE ESOPHAUS
US5459325A (en) 1994-07-19 1995-10-17 Molecular Dynamics, Inc. High-speed fluorescence scanner
US6159445A (en) 1994-07-20 2000-12-12 Nycomed Imaging As Light imaging contrast agents
DE69533903T2 (en) 1994-08-18 2005-12-08 Carl Zeiss Meditec Ag Surgical apparatus controlled by optical coherence tomography
US5491524A (en) * 1994-10-05 1996-02-13 Carl Zeiss, Inc. Optical coherence tomography corneal mapping apparatus
US5740808A (en) 1996-10-28 1998-04-21 Ep Technologies, Inc Systems and methods for guilding diagnostic or therapeutic devices in interior tissue regions
US5817144A (en) 1994-10-25 1998-10-06 Latis, Inc. Method for contemporaneous application OF laser energy and localized pharmacologic therapy
US6033721A (en) * 1994-10-26 2000-03-07 Revise, Inc. Image-based three-axis positioner for laser direct write microchemical reaction
JPH08136345A (en) 1994-11-10 1996-05-31 Anritsu Corp Double monochromator
US5566267A (en) 1994-12-15 1996-10-15 Ceram Optec Industries Inc. Flat surfaced optical fibers and diode laser medical delivery devices
US5600486A (en) * 1995-01-30 1997-02-04 Lockheed Missiles And Space Company, Inc. Color separation microlens
US5648848A (en) 1995-02-01 1997-07-15 Nikon Precision, Inc. Beam delivery apparatus and method for interferometry using rotatable polarization chucks
DE19506484C2 (en) * 1995-02-24 1999-09-16 Stiftung Fuer Lasertechnologie Method and device for selective non-invasive laser myography (LMG)
RU2100787C1 (en) 1995-03-01 1997-12-27 Геликонов Валентин Михайлович Fibre-optical interferometer and fiber-optical piezoelectric transducer
US5868731A (en) 1996-03-04 1999-02-09 Innotech Usa, Inc. Laser surgical device and method of its use
WO1996028212A1 (en) 1995-03-09 1996-09-19 Innotech Usa, Inc. Laser surgical device and method of its use
US5526338A (en) 1995-03-10 1996-06-11 Yeda Research & Development Co. Ltd. Method and apparatus for storage and retrieval with multilayer optical disks
US5697373A (en) 1995-03-14 1997-12-16 Board Of Regents, The University Of Texas System Optical method and apparatus for the diagnosis of cervical precancers using raman and fluorescence spectroscopies
US5735276A (en) * 1995-03-21 1998-04-07 Lemelson; Jerome Method and apparatus for scanning and evaluating matter
JP3945820B2 (en) 1995-03-24 2007-07-18 オプティスキャン ピーティーワイ リミテッド Optical fiber confocal image forming apparatus with variable near-confocal control means
US5565983A (en) 1995-05-26 1996-10-15 The Perkin-Elmer Corporation Optical spectrometer for detecting spectra in separate ranges
US5785651A (en) 1995-06-07 1998-07-28 Keravision, Inc. Distance measuring confocal microscope
US5621830A (en) 1995-06-07 1997-04-15 Smith & Nephew Dyonics Inc. Rotatable fiber optic joint
WO1997001167A1 (en) 1995-06-21 1997-01-09 Massachusetts Institute Of Technology Apparatus and method for accessing data on multilayered optical media
ATA107495A (en) 1995-06-23 1996-06-15 Fercher Adolf Friedrich Dr COHERENCE BIOMETRY AND TOMOGRAPHY WITH DYNAMIC COHERENT FOCUS
US6104945A (en) 1995-08-01 2000-08-15 Medispectra, Inc. Spectral volume microprobe arrays
JP3819032B2 (en) * 1995-08-24 2006-09-06 ザ・テキサス・エイ・アンド・エム・ユニバーシティ・システム Imaging and spectroscopic analysis based on fluorescence lifetime in tissues and other random media
US6016197A (en) 1995-08-25 2000-01-18 Ceramoptec Industries Inc. Compact, all-optical spectrum analyzer for chemical and biological fiber optic sensors
FR2738343B1 (en) 1995-08-30 1997-10-24 Cohen Sabban Joseph OPTICAL MICROSTRATIGRAPHY DEVICE
EP0955883B1 (en) 1995-09-20 2002-07-31 Texas Heart Institute Detecting thermal discrepancies in vessel walls
US6763261B2 (en) 1995-09-20 2004-07-13 Board Of Regents, The University Of Texas System Method and apparatus for detecting vulnerable atherosclerotic plaque
US6615071B1 (en) 1995-09-20 2003-09-02 Board Of Regents, The University Of Texas System Method and apparatus for detecting vulnerable atherosclerotic plaque
US5742419A (en) 1995-11-07 1998-04-21 The Board Of Trustees Of The Leland Stanford Junior Universtiy Miniature scanning confocal microscope
DE19542955C2 (en) 1995-11-17 1999-02-18 Schwind Gmbh & Co Kg Herbert endoscope
US5719399A (en) * 1995-12-18 1998-02-17 The Research Foundation Of City College Of New York Imaging and characterization of tissue based upon the preservation of polarized light transmitted therethrough
JP3699761B2 (en) 1995-12-26 2005-09-28 オリンパス株式会社 Epifluorescence microscope
US5748318A (en) * 1996-01-23 1998-05-05 Brown University Research Foundation Optical stress generator and detector
US5840023A (en) 1996-01-31 1998-11-24 Oraevsky; Alexander A. Optoacoustic imaging for medical diagnosis
US5642194A (en) 1996-02-05 1997-06-24 The Regents Of The University Of California White light velocity interferometer
US5862273A (en) 1996-02-23 1999-01-19 Kaiser Optical Systems, Inc. Fiber optic probe with integral optical filtering
US5843000A (en) 1996-05-07 1998-12-01 The General Hospital Corporation Optical biopsy forceps and method of diagnosing tissue
ATA84696A (en) * 1996-05-14 1998-03-15 Adolf Friedrich Dr Fercher METHOD AND ARRANGEMENTS FOR INCREASING CONTRAST IN OPTICAL COHERENCE TOMOGRAPHY
US6020963A (en) * 1996-06-04 2000-02-01 Northeastern University Optical quadrature Interferometer
US5795295A (en) 1996-06-25 1998-08-18 Carl Zeiss, Inc. OCT-assisted surgical microscope with multi-coordinate manipulator
US5842995A (en) 1996-06-28 1998-12-01 Board Of Regents, The Univerisity Of Texas System Spectroscopic probe for in vivo measurement of raman signals
US6296608B1 (en) 1996-07-08 2001-10-02 Boston Scientific Corporation Diagnosing and performing interventional procedures on tissue in vivo
US6245026B1 (en) 1996-07-29 2001-06-12 Farallon Medsystems, Inc. Thermography catheter
US6396941B1 (en) 1996-08-23 2002-05-28 Bacus Research Laboratories, Inc. Method and apparatus for internet, intranet, and local viewing of virtual microscope slides
US5840075A (en) 1996-08-23 1998-11-24 Eclipse Surgical Technologies, Inc. Dual laser device for transmyocardial revascularization procedures
US6544193B2 (en) 1996-09-04 2003-04-08 Marcio Marc Abreu Noninvasive measurement of chemical substances
JPH1090603A (en) 1996-09-18 1998-04-10 Olympus Optical Co Ltd Endscopic optical system
US5801831A (en) 1996-09-20 1998-09-01 Institute For Space And Terrestrial Science Fabry-Perot spectrometer for detecting a spatially varying spectral signature of an extended source
US6249349B1 (en) 1996-09-27 2001-06-19 Vincent Lauer Microscope generating a three-dimensional representation of an object
DE19640495C2 (en) 1996-10-01 1999-12-16 Leica Microsystems Device for confocal surface measurement
US5843052A (en) 1996-10-04 1998-12-01 Benja-Athon; Anuthep Irrigation kit for application of fluids and chemicals for cleansing and sterilizing wounds
US5904651A (en) 1996-10-28 1999-05-18 Ep Technologies, Inc. Systems and methods for visualizing tissue during diagnostic or therapeutic procedures
US5752518A (en) 1996-10-28 1998-05-19 Ep Technologies, Inc. Systems and methods for visualizing interior regions of the body
US6044288A (en) * 1996-11-08 2000-03-28 Imaging Diagnostics Systems, Inc. Apparatus and method for determining the perimeter of the surface of an object being scanned
US5872879A (en) 1996-11-25 1999-02-16 Boston Scientific Corporation Rotatable connecting optical fibers
US6517532B1 (en) 1997-05-15 2003-02-11 Palomar Medical Technologies, Inc. Light energy delivery head
US6437867B2 (en) 1996-12-04 2002-08-20 The Research Foundation Of The City University Of New York Performing selected optical measurements with optical coherence domain reflectometry
US6249630B1 (en) 1996-12-13 2001-06-19 Imra America, Inc. Apparatus and method for delivery of dispersion-compensated ultrashort optical pulses with high peak power
US5871449A (en) * 1996-12-27 1999-02-16 Brown; David Lloyd Device and method for locating inflamed plaque in an artery
US5991697A (en) 1996-12-31 1999-11-23 The Regents Of The University Of California Method and apparatus for optical Doppler tomographic imaging of fluid flow velocity in highly scattering media
WO1998029768A1 (en) 1996-12-31 1998-07-09 Corning Incorporated Optical couplers with multilayer fibers
US5760901A (en) 1997-01-28 1998-06-02 Zetetic Institute Method and apparatus for confocal interference microscopy with background amplitude reduction and compensation
JP3213250B2 (en) 1997-01-29 2001-10-02 株式会社生体光情報研究所 Optical measurement device
US5801826A (en) 1997-02-18 1998-09-01 Williams Family Trust B Spectrometric device and method for recognizing atomic and molecular signatures
US5836877A (en) 1997-02-24 1998-11-17 Lucid Inc System for facilitating pathological examination of a lesion in tissue
US6120516A (en) 1997-02-28 2000-09-19 Lumend, Inc. Method for treating vascular occlusion
US6010449A (en) * 1997-02-28 2000-01-04 Lumend, Inc. Intravascular catheter system for treating a vascular occlusion
US5968064A (en) 1997-02-28 1999-10-19 Lumend, Inc. Catheter system for treating a vascular occlusion
WO1998038907A1 (en) 1997-03-06 1998-09-11 Massachusetts Institute Of Technology Instrument for optically scanning of living tissue
CA2283949A1 (en) * 1997-03-13 1998-09-17 Haishan Zeng Methods and apparatus for detecting the rejection of transplanted tissue
US6078047A (en) 1997-03-14 2000-06-20 Lucent Technologies Inc. Method and apparatus for terahertz tomographic imaging
US5994690A (en) 1997-03-17 1999-11-30 Kulkarni; Manish D. Image enhancement in optical coherence tomography using deconvolution
JPH10267830A (en) 1997-03-26 1998-10-09 Kowa Co Optical measuring device
JPH10267631A (en) 1997-03-26 1998-10-09 Kowa Co Optical measuring instrument
GB9707414D0 (en) 1997-04-11 1997-05-28 Imperial College Anatomical probe
TW333339U (en) 1997-04-24 1998-06-01 De-Chin Su Substrate type full image optical element for laser light source alignment and its shape correction semiconductor
WO1998048846A1 (en) 1997-04-29 1998-11-05 Nycomed Imaging As Light imaging contrast agents
WO1998048845A1 (en) 1997-04-29 1998-11-05 Nycomed Imaging As Method of demarcating tissue
US6117128A (en) 1997-04-30 2000-09-12 Kenton W. Gregory Energy delivery catheter and method for the use thereof
US5887009A (en) * 1997-05-22 1999-03-23 Optical Biopsy Technologies, Inc. Confocal optical scanning system employing a fiber laser
US6002480A (en) 1997-06-02 1999-12-14 Izatt; Joseph A. Depth-resolved spectroscopic optical coherence tomography
EP1007901B1 (en) 1997-06-02 2009-04-29 Joseph A. Izatt Doppler flow imaging using optical coherence tomography
US6208415B1 (en) * 1997-06-12 2001-03-27 The Regents Of The University Of California Birefringence imaging in biological tissue using polarization sensitive optical coherent tomography
US5920390A (en) 1997-06-26 1999-07-06 University Of North Carolina Fiberoptic interferometer and associated method for analyzing tissue
US6048349A (en) 1997-07-09 2000-04-11 Intraluminal Therapeutics, Inc. Systems and methods for guiding a medical instrument through a body
US6058352A (en) 1997-07-25 2000-05-02 Physical Optics Corporation Accurate tissue injury assessment using hybrid neural network analysis
US5921926A (en) 1997-07-28 1999-07-13 University Of Central Florida Three dimensional optical imaging colposcopy
US6014214A (en) * 1997-08-21 2000-01-11 Li; Ming-Chiang High speed inspection of a sample using coherence processing of scattered superbroad radiation
US5892583A (en) 1997-08-21 1999-04-06 Li; Ming-Chiang High speed inspection of a sample using superbroad radiation coherent interferometer
US6069698A (en) 1997-08-28 2000-05-30 Olympus Optical Co., Ltd. Optical imaging apparatus which radiates a low coherence light beam onto a test object, receives optical information from light scattered by the object, and constructs therefrom a cross-sectional image of the object
US6297018B1 (en) 1998-04-17 2001-10-02 Ljl Biosystems, Inc. Methods and apparatus for detecting nucleic acid polymorphisms
US5920373A (en) 1997-09-24 1999-07-06 Heidelberg Engineering Optische Messysteme Gmbh Method and apparatus for determining optical characteristics of a cornea
US6193676B1 (en) * 1997-10-03 2001-02-27 Intraluminal Therapeutics, Inc. Guide wire assembly
US5951482A (en) 1997-10-03 1999-09-14 Intraluminal Therapeutics, Inc. Assemblies and methods for advancing a guide wire through body tissue
US6091984A (en) 1997-10-10 2000-07-18 Massachusetts Institute Of Technology Measuring tissue morphology
US5955737A (en) 1997-10-27 1999-09-21 Systems & Processes Engineering Corporation Chemometric analysis for extraction of individual fluorescence spectrum and lifetimes from a target mixture
US6486997B1 (en) 1997-10-28 2002-11-26 3M Innovative Properties Company Reflective LCD projection system using wide-angle Cartesian polarizing beam splitter
US6134010A (en) 1997-11-07 2000-10-17 Lucid, Inc. Imaging system using polarization effects to enhance image quality
US6037579A (en) * 1997-11-13 2000-03-14 Biophotonics Information Laboratories, Ltd. Optical interferometer employing multiple detectors to detect spatially distorted wavefront in imaging of scattering media
US6107048A (en) 1997-11-20 2000-08-22 Medical College Of Georgia Research Institute, Inc. Method of detecting and grading dysplasia in epithelial tissue
EP1103041B1 (en) 1998-01-28 2016-03-23 Immersion Medical, Inc. Interface device and method for interfacing instruments to medical procedure simulation system
US6165170A (en) 1998-01-29 2000-12-26 International Business Machines Corporation Laser dermablator and dermablation
US6048742A (en) * 1998-02-26 2000-04-11 The United States Of America As Represented By The Secretary Of The Air Force Process for measuring the thickness and composition of thin semiconductor films deposited on semiconductor wafers
US6134033A (en) 1998-02-26 2000-10-17 Tyco Submarine Systems Ltd. Method and apparatus for improving spectral efficiency in wavelength division multiplexed transmission systems
US6831781B2 (en) 1998-02-26 2004-12-14 The General Hospital Corporation Confocal microscopy with multi-spectral encoding and system and apparatus for spectroscopically encoded confocal microscopy
EP2267506A3 (en) 1998-02-26 2011-03-02 The General Hospital Corporation Confocal microscopy with multi-spectral encoding
RU2148378C1 (en) 1998-03-06 2000-05-10 Геликонов Валентин Михайлович Device for performing optic coherent tomography, optic fiber scanning device and method for diagnosing biological tissue in vivo
US6174291B1 (en) 1998-03-09 2001-01-16 Spectrascience, Inc. Optical biopsy system and methods for tissue diagnosis
US6066102A (en) 1998-03-09 2000-05-23 Spectrascience, Inc. Optical biopsy forceps system and method of diagnosing tissue
US6151522A (en) 1998-03-16 2000-11-21 The Research Foundation Of Cuny Method and system for examining biological materials using low power CW excitation raman spectroscopy
DE19814057B4 (en) * 1998-03-30 2009-01-02 Carl Zeiss Meditec Ag Arrangement for optical coherence tomography and coherence topography
US6175669B1 (en) * 1998-03-30 2001-01-16 The Regents Of The Universtiy Of California Optical coherence domain reflectometry guidewire
US6384915B1 (en) 1998-03-30 2002-05-07 The Regents Of The University Of California Catheter guided by optical coherence domain reflectometry
US6996549B2 (en) 1998-05-01 2006-02-07 Health Discovery Corporation Computer-aided image analysis
AU3781799A (en) 1998-05-01 1999-11-23 Board Of Regents, The University Of Texas System Method and apparatus for subsurface imaging
JPH11326826A (en) 1998-05-13 1999-11-26 Sony Corp Illuminating method and illuminator
US6053613A (en) * 1998-05-15 2000-04-25 Carl Zeiss, Inc. Optical coherence tomography with new interferometer
FR2778838A1 (en) 1998-05-19 1999-11-26 Koninkl Philips Electronics Nv METHOD FOR DETECTING VARIATIONS IN ELASTICITY AND ECHOGRAPHIC APPARATUS FOR CARRYING OUT THIS METHOD
US5995223A (en) 1998-06-01 1999-11-30 Power; Joan Fleurette Apparatus for rapid phase imaging interferometry and method therefor
JPH11352409A (en) 1998-06-05 1999-12-24 Olympus Optical Co Ltd Fluorescence detector
US6549801B1 (en) * 1998-06-11 2003-04-15 The Regents Of The University Of California Phase-resolved optical coherence tomography and optical doppler tomography for imaging fluid flow in tissue with fast scanning speed and high velocity sensitivity
EP1100392B1 (en) 1998-07-15 2009-02-25 Corazon Technologies, Inc. devices for reducing the mineral content of vascular calcified lesions
US6166373A (en) 1998-07-21 2000-12-26 The Institute For Technology Development Focal plane scanner with reciprocating spatial window
JP2000046729A (en) 1998-07-31 2000-02-18 Takahisa Mitsui Apparatus and method for high-speed measurement of optical topographic image by using wavelength dispersion
US6039091A (en) * 1998-08-03 2000-03-21 Mentor Corporation Filling device for use in manufacturing of gel filled prostheses
JP4474050B2 (en) 1998-09-11 2010-06-02 スペクトルックス・インコーポレイテッド Multi-mode optical tissue diagnosis system
AU6417599A (en) 1998-10-08 2000-04-26 University Of Kentucky Research Foundation, The Methods and apparatus for (in vivo) identification and characterization of vulnerable atherosclerotic plaques
JP2000121961A (en) 1998-10-13 2000-04-28 Olympus Optical Co Ltd Confocal optical scanning probe system
US6274871B1 (en) 1998-10-22 2001-08-14 Vysis, Inc. Method and system for performing infrared study on a biological sample
US6324419B1 (en) 1998-10-27 2001-11-27 Nejat Guzelsu Apparatus and method for non-invasive measurement of stretch
JP2000126116A (en) 1998-10-28 2000-05-09 Olympus Optical Co Ltd Photo-diagnosis system
US6059109A (en) * 1998-11-09 2000-05-09 Olympia Industrial, Inc. Article storage tray
US6516014B1 (en) 1998-11-13 2003-02-04 The Research And Development Institute, Inc. Programmable frequency reference for laser frequency stabilization, and arbitrary optical clock generator, using persistent spectral hole burning
EP1002497B1 (en) 1998-11-20 2006-07-26 Fuji Photo Film Co., Ltd. Blood vessel imaging system
US5975697A (en) 1998-11-25 1999-11-02 Oti Ophthalmic Technologies, Inc. Optical mapping apparatus with adjustable depth resolution
US6352502B1 (en) 1998-12-03 2002-03-05 Lightouch Medical, Inc. Methods for obtaining enhanced spectroscopic information from living tissue, noninvasive assessment of skin condition and detection of skin abnormalities
US6191862B1 (en) 1999-01-20 2001-02-20 Lightlab Imaging, Llc Methods and apparatus for high speed longitudinal scanning in imaging systems
US6272376B1 (en) 1999-01-22 2001-08-07 Cedars-Sinai Medical Center Time-resolved, laser-induced fluorescence for the characterization of organic material
US6445944B1 (en) 1999-02-01 2002-09-03 Scimed Life Systems Medical scanning system and related method of scanning
US6615072B1 (en) 1999-02-04 2003-09-02 Olympus Optical Co., Ltd. Optical imaging device
US6185271B1 (en) * 1999-02-16 2001-02-06 Richard Estyn Kinsinger Helical computed tomography with feedback scan control
DE19908883A1 (en) 1999-03-02 2000-09-07 Rainer Heintzmann Process for increasing the resolution of optical imaging
CA2367804A1 (en) 1999-03-29 2000-10-05 Mark A. Hamm Single mode optical fiber coupling systems
US6859275B2 (en) 1999-04-09 2005-02-22 Plain Sight Systems, Inc. System and method for encoded spatio-spectral information processing
US6264610B1 (en) 1999-05-05 2001-07-24 The University Of Connecticut Combined ultrasound and near infrared diffused light imaging system
US6353693B1 (en) * 1999-05-31 2002-03-05 Sanyo Electric Co., Ltd. Optical communication device and slip ring unit for an electronic component-mounting apparatus
US6993170B2 (en) 1999-06-23 2006-01-31 Icoria, Inc. Method for quantitative analysis of blood vessel structure
JP2001004447A (en) 1999-06-23 2001-01-12 Yokogawa Electric Corp Spectrometer
US6611833B1 (en) 1999-06-23 2003-08-26 Tissueinformatics, Inc. Methods for profiling and classifying tissue using a database that includes indices representative of a tissue population
US6208887B1 (en) * 1999-06-24 2001-03-27 Richard H. Clarke Catheter-delivered low resolution Raman scattering analyzing system for detecting lesions
US7426409B2 (en) 1999-06-25 2008-09-16 Board Of Regents, The University Of Texas System Method and apparatus for detecting vulnerable atherosclerotic plaque
GB9915082D0 (en) 1999-06-28 1999-08-25 Univ London Optical fibre probe
US6359692B1 (en) * 1999-07-09 2002-03-19 Zygo Corporation Method and system for profiling objects having multiple reflective surfaces using wavelength-tuning phase-shifting interferometry
JP2003504627A (en) 1999-07-13 2003-02-04 クロマビジョン メディカル システムズ インコーポレイテッド Automatic detection of objects in biological samples
DE60020566T2 (en) 1999-07-30 2006-05-04 Boston Scientific Ltd., St. Michael CATHETER WITH DRIVE AND CLUTCH FOR TURNING AND LENGTH SHIFTING
DE60032637T2 (en) 1999-07-30 2007-11-15 Ceramoptec Gmbh MEDICAL DIODE LASER SYSTEM WITH TWO WAVE LENGTHS
JP2001046321A (en) 1999-08-09 2001-02-20 Asahi Optical Co Ltd Endoscope device
US6445939B1 (en) 1999-08-09 2002-09-03 Lightlab Imaging, Llc Ultra-small optical probes, imaging optics, and methods for using same
US6725073B1 (en) 1999-08-17 2004-04-20 Board Of Regents, The University Of Texas System Methods for noninvasive analyte sensing
JP3869589B2 (en) 1999-09-02 2007-01-17 ペンタックス株式会社 Fiber bundle and endoscope apparatus
US6687010B1 (en) * 1999-09-09 2004-02-03 Olympus Corporation Rapid depth scanning optical imaging device
JP4464519B2 (en) 2000-03-21 2010-05-19 オリンパス株式会社 Optical imaging device
US6198956B1 (en) * 1999-09-30 2001-03-06 Oti Ophthalmic Technologies Inc. High speed sector scanning apparatus having digital electronic control
JP2001174744A (en) 1999-10-06 2001-06-29 Olympus Optical Co Ltd Optical scanning probe device
US6393312B1 (en) 1999-10-13 2002-05-21 C. R. Bard, Inc. Connector for coupling an optical fiber tissue localization device to a light source
US6308092B1 (en) 1999-10-13 2001-10-23 C. R. Bard Inc. Optical fiber tissue localization device
AU1182401A (en) 1999-10-15 2001-04-23 Cellavision Ab Microscope and method for manufacturing a composite image with a high resolution
US6538817B1 (en) * 1999-10-25 2003-03-25 Aculight Corporation Method and apparatus for optical coherence tomography with a multispectral laser source
JP2001125009A (en) 1999-10-28 2001-05-11 Asahi Optical Co Ltd Endoscope
IL132687A0 (en) 1999-11-01 2001-03-19 Keren Mechkarim Ichilov Pnimit System and method for evaluating body fluid samples
US6836546B1 (en) * 1999-11-03 2004-12-28 Advanced Micro Devices, Inc. Apparatus and method of coupling home network signals between an analog phone line and a digital bus
WO2001036948A1 (en) 1999-11-19 2001-05-25 Jobin Yvon, Inc. Compact spectrofluorometer
US7236637B2 (en) 1999-11-24 2007-06-26 Ge Medical Systems Information Technologies, Inc. Method and apparatus for transmission and display of a compressed digitized image
ATE263356T1 (en) 1999-11-24 2004-04-15 Haag Ag Streit METHOD AND DEVICE FOR MEASURING OPTICAL PROPERTIES OF AT LEAST TWO DISTANCED AREAS IN A TRANSPARENT AND/OR DIFFUSIVE OBJECT
JP2003516531A (en) * 1999-12-09 2003-05-13 オーティーアイ オフサルミック テクノロジーズ インク Optical mapping device with variable depth resolution
JP2001174404A (en) 1999-12-15 2001-06-29 Takahisa Mitsui Apparatus and method for measuring optical tomographic image
US6738144B1 (en) 1999-12-17 2004-05-18 University Of Central Florida Non-invasive method and low-coherence apparatus system analysis and process control
US6680780B1 (en) * 1999-12-23 2004-01-20 Agere Systems, Inc. Interferometric probe stabilization relative to subject movement
US6445485B1 (en) * 2000-01-21 2002-09-03 At&T Corp. Micro-machine polarization-state controller
AU2001229916A1 (en) 2000-01-27 2001-08-07 National Research Council Of Canada Visible-near infrared spectroscopy in burn injury assessment
JP3660185B2 (en) 2000-02-07 2005-06-15 独立行政法人科学技術振興機構 Tomographic image forming method and apparatus therefor
US6475210B1 (en) 2000-02-11 2002-11-05 Medventure Technology Corp Light treatment of vulnerable atherosclerosis plaque
DE50101290D1 (en) * 2000-02-11 2004-02-12 E & E Elektronik Gmbh SENSOR ARRANGEMENT
US6556305B1 (en) 2000-02-17 2003-04-29 Veeco Instruments, Inc. Pulsed source scanning interferometer
US6618143B2 (en) 2000-02-18 2003-09-09 Idexx Laboratories, Inc. High numerical aperture flow cytometer and method of using same
US6751490B2 (en) 2000-03-01 2004-06-15 The Board Of Regents Of The University Of Texas System Continuous optoacoustic monitoring of hemoglobin concentration and hematocrit
JP2001272331A (en) * 2000-03-24 2001-10-05 Japan Science & Technology Corp Spatial delay type fizeau interferometer
US6593101B2 (en) 2000-03-28 2003-07-15 Board Of Regents, The University Of Texas System Enhancing contrast in biological imaging
US6687013B2 (en) 2000-03-28 2004-02-03 Hitachi, Ltd. Laser interferometer displacement measuring system, exposure apparatus, and electron beam lithography apparatus
US6567585B2 (en) 2000-04-04 2003-05-20 Optiscan Pty Ltd Z sharpening for fibre confocal microscopes
US6692430B2 (en) 2000-04-10 2004-02-17 C2Cure Inc. Intra vascular imaging apparatus
EP1299057A2 (en) 2000-04-27 2003-04-09 Iridex Corporation Method and apparatus for real-time detection, control and recording of sub-clinical therapeutic laser lesions during ocular laser photocoagulation
AU2001259435A1 (en) * 2000-05-03 2001-11-12 Stephen T Flock Optical imaging of subsurface anatomical structures and biomolecules
US6301048B1 (en) 2000-05-19 2001-10-09 Avanex Corporation Tunable chromatic dispersion and dispersion slope compensator utilizing a virtually imaged phased array
US6441959B1 (en) 2000-05-19 2002-08-27 Avanex Corporation Method and system for testing a tunable chromatic dispersion, dispersion slope, and polarization mode dispersion compensator utilizing a virtually imaged phased array
US6560259B1 (en) 2000-05-31 2003-05-06 Applied Optoelectronics, Inc. Spatially coherent surface-emitting, grating coupled quantum cascade laser with unstable resonance cavity
JP4460117B2 (en) 2000-06-29 2010-05-12 独立行政法人理化学研究所 Grism
JP2002035005A (en) 2000-07-21 2002-02-05 Olympus Optical Co Ltd Therapeutic device
US6757467B1 (en) 2000-07-25 2004-06-29 Optical Air Data Systems, Lp Optical fiber system
US6441356B1 (en) 2000-07-28 2002-08-27 Optical Biopsy Technologies Fiber-coupled, high-speed, angled-dual-axis optical coherence scanning microscopes
US6882432B2 (en) 2000-08-08 2005-04-19 Zygo Corporation Frequency transform phase shifting interferometry
AU2001279603A1 (en) 2000-08-11 2002-02-25 Crystal Fibre A/S Optical wavelength converter
US7625335B2 (en) 2000-08-25 2009-12-01 3Shape Aps Method and apparatus for three-dimensional optical scanning of interior surfaces
DE10042840A1 (en) 2000-08-30 2002-03-14 Leica Microsystems Device and method for exciting fluorescence microscope markers in multiphoton scanning microscopy
WO2002021170A1 (en) 2000-09-05 2002-03-14 Arroyo Optics, Inc. System and method for fabricating components of precise optical path length
JP2002095663A (en) 2000-09-26 2002-04-02 Fuji Photo Film Co Ltd Method of acquiring optical tomographic image of sentinel lymph node and its device
JP2002113017A (en) 2000-10-05 2002-04-16 Fuji Photo Film Co Ltd Laser treatment device
ATE454845T1 (en) 2000-10-30 2010-01-15 Gen Hospital Corp OPTICAL SYSTEMS FOR TISSUE ANALYSIS
ATE437350T1 (en) 2000-10-31 2009-08-15 Univ Danmarks Tekniske OPTICAL AMPLIFICATION IN COHERENT OPTICAL FREQUENCY MODULATED CONTINUOUS REFLECTOMETRY
JP3842101B2 (en) 2000-10-31 2006-11-08 富士写真フイルム株式会社 Endoscope device
US6687036B2 (en) * 2000-11-03 2004-02-03 Nuonics, Inc. Multiplexed optical scanner technology
JP2002148185A (en) 2000-11-08 2002-05-22 Fuji Photo Film Co Ltd Oct apparatus
US9295391B1 (en) 2000-11-10 2016-03-29 The General Hospital Corporation Spectrally encoded miniature endoscopic imaging probe
EP1409721A2 (en) 2000-11-13 2004-04-21 Gnothis Holding SA Detection of nucleic acid polymorphisms
US6665075B2 (en) 2000-11-14 2003-12-16 Wm. Marshurice University Interferometric imaging system and method
DE10057539B4 (en) 2000-11-20 2008-06-12 Robert Bosch Gmbh Interferometric measuring device
US6558324B1 (en) 2000-11-22 2003-05-06 Siemens Medical Solutions, Inc., Usa System and method for strain image display
US6856712B2 (en) 2000-11-27 2005-02-15 University Of Washington Micro-fabricated optical waveguide for use in scanning fiber displays and scanned fiber image acquisition
US7027633B2 (en) 2000-11-30 2006-04-11 Foran David J Collaborative diagnostic systems
JP4786027B2 (en) 2000-12-08 2011-10-05 オリンパス株式会社 Optical system and optical apparatus
US6687007B1 (en) * 2000-12-14 2004-02-03 Kestrel Corporation Common path interferometer for spectral image generation
US6501878B2 (en) 2000-12-14 2002-12-31 Nortel Networks Limited Optical fiber termination
US7230708B2 (en) 2000-12-28 2007-06-12 Dmitri Olegovich Lapotko Method and device for photothermal examination of microinhomogeneities
CA2433022C (en) 2000-12-28 2016-12-06 Palomar Medical Technologies, Inc. Method and apparatus for therapeutic emr treatment of the skin
US6515752B2 (en) 2000-12-28 2003-02-04 Coretek, Inc. Wavelength monitoring system
EP1221581A1 (en) 2001-01-04 2002-07-10 Universität Stuttgart Interferometer
JP2002205434A (en) 2001-01-10 2002-07-23 Seiko Epson Corp Image output unit and printing system
US7285091B2 (en) 2001-01-11 2007-10-23 The Johns Hopkins University Assessment of tooth structure using laser based ultrasonics
US7177491B2 (en) 2001-01-12 2007-02-13 Board Of Regents The University Of Texas System Fiber-based optical low coherence tomography
JP3628615B2 (en) 2001-01-16 2005-03-16 独立行政法人科学技術振興機構 Heterodyne beat image synchronous measurement device
US6697652B2 (en) 2001-01-19 2004-02-24 Massachusetts Institute Of Technology Fluorescence, reflectance and light scattering spectroscopy for measuring tissue
EP1358443A2 (en) 2001-01-22 2003-11-05 Jonathan E. Roth Method and apparatus for polarization-sensitive optical coherence tomography
US7973936B2 (en) 2001-01-30 2011-07-05 Board Of Trustees Of Michigan State University Control system and apparatus for use with ultra-fast laser
US20020140942A1 (en) 2001-02-17 2002-10-03 Fee Michale Sean Acousto-optic monitoring and imaging in a depth sensitive manner
GB0104378D0 (en) 2001-02-22 2001-04-11 Expro North Sea Ltd Improved tubing coupling
US6654127B2 (en) 2001-03-01 2003-11-25 Carl Zeiss Ophthalmic Systems, Inc. Optical delay line
US6721094B1 (en) 2001-03-05 2004-04-13 Sandia Corporation Long working distance interference microscope
US7244232B2 (en) 2001-03-07 2007-07-17 Biomed Solutions, Llc Process for identifying cancerous and/or metastatic cells of a living organism
IL142773A (en) 2001-03-08 2007-10-31 Xtellus Inc Fiber optical attenuator
JP2002263055A (en) 2001-03-12 2002-09-17 Olympus Optical Co Ltd Tip hood for endoscope
US6563995B2 (en) 2001-04-02 2003-05-13 Lightwave Electronics Optical wavelength filtering apparatus with depressed-index claddings
US6552796B2 (en) * 2001-04-06 2003-04-22 Lightlab Imaging, Llc Apparatus and method for selective data collection and signal to noise ratio enhancement using optical coherence tomography
US7139598B2 (en) 2002-04-04 2006-11-21 Veralight, Inc. Determination of a measure of a glycation end-product or disease state using tissue fluorescence
WO2002083003A1 (en) 2001-04-11 2002-10-24 Clarke Dana S Tissue structure identification in advance of instrument
US20020158211A1 (en) 2001-04-16 2002-10-31 Dakota Technologies, Inc. Multi-dimensional fluorescence apparatus and method for rapid and highly sensitive quantitative analysis of mixtures
DE10118760A1 (en) 2001-04-17 2002-10-31 Med Laserzentrum Luebeck Gmbh Procedure for determining the runtime distribution and arrangement
EP2333523B1 (en) 2001-04-30 2020-04-08 The General Hospital Corporation Method and apparatus for improving image clarity and sensitivity in optical coherence tomography using dynamic feedback to control focal properties and coherence gating
US7616986B2 (en) 2001-05-07 2009-11-10 University Of Washington Optical fiber scanner for performing multimodal optical imaging
US6701181B2 (en) * 2001-05-31 2004-03-02 Infraredx, Inc. Multi-path optical catheter
US6615062B2 (en) 2001-05-31 2003-09-02 Infraredx, Inc. Referencing optical catheters
DE60219627T2 (en) 2001-06-04 2008-02-07 The General Hospital Corp., Boston IDENTIFICATION AND THERAPY OF SENSITIVE PLAQUE WITH PHOTODYNAMIC COMPOUNDS
EP1191321B1 (en) 2001-06-07 2002-12-11 Agilent Technologies, Inc. (a Delaware corporation) Determination of properties of an optical device
US6879851B2 (en) 2001-06-07 2005-04-12 Lightlab Imaging, Llc Fiber optic endoscopic gastrointestinal probe
DE10129651B4 (en) 2001-06-15 2010-07-08 Carl Zeiss Jena Gmbh Method for compensation of the dispersion in signals of short-coherence and / or OCT interferometers
US6702744B2 (en) 2001-06-20 2004-03-09 Advanced Cardiovascular Systems, Inc. Agents that stimulate therapeutic angiogenesis and techniques and devices that enable their delivery
US6685885B2 (en) * 2001-06-22 2004-02-03 Purdue Research Foundation Bio-optical compact dist system
US20040166593A1 (en) 2001-06-22 2004-08-26 Nolte David D. Adaptive interferometric multi-analyte high-speed biosensor
US6723090B2 (en) 2001-07-02 2004-04-20 Palomar Medical Technologies, Inc. Fiber laser device for medical/cosmetic procedures
DE10137530A1 (en) 2001-08-01 2003-02-13 Presens Prec Sensing Gmbh Arrangement and method for multiple fluorescence measurement
AU2002337666A1 (en) 2001-08-03 2003-02-17 Joseph A. Izatt Aspects of basic oct engine technologies for high speed optical coherence tomography and light source and other improvements in oct
US20030030816A1 (en) 2001-08-11 2003-02-13 Eom Tae Bong Nonlinearity error correcting method and phase angle measuring method for displacement measurement in two-freqency laser interferometer and displacement measurement system using the same
US6900899B2 (en) 2001-08-20 2005-05-31 Agilent Technologies, Inc. Interferometers with coated polarizing beam splitters that are rotated to optimize extinction ratios
US20030045798A1 (en) 2001-09-04 2003-03-06 Richard Hular Multisensor probe for tissue identification
EP1293925A1 (en) 2001-09-18 2003-03-19 Agfa-Gevaert Radiographic scoring method
US6961123B1 (en) 2001-09-28 2005-11-01 The Texas A&M University System Method and apparatus for obtaining information from polarization-sensitive optical coherence tomography
JP2003102672A (en) 2001-10-01 2003-04-08 Japan Science & Technology Corp Method and device for automatically detecting, treating, and collecting objective site of lesion or the like
DE10150934A1 (en) 2001-10-09 2003-04-10 Zeiss Carl Jena Gmbh Depth resolved measurement and imaging of biological samples using laser scanning microscopy, whereby heterodyne detection and optical modulation is used to allow imaging of deep sample regions
US7822470B2 (en) 2001-10-11 2010-10-26 Osypka Medical Gmbh Method for determining the left-ventricular ejection time TLVE of a heart of a subject
US6980299B1 (en) 2001-10-16 2005-12-27 General Hospital Corporation Systems and methods for imaging a sample
US6658278B2 (en) 2001-10-17 2003-12-02 Terumo Cardiovascular Systems Corporation Steerable infrared imaging catheter having steering fins
US7006231B2 (en) * 2001-10-18 2006-02-28 Scimed Life Systems, Inc. Diffraction grating based interferometric systems and methods
US6749344B2 (en) 2001-10-24 2004-06-15 Scimed Life Systems, Inc. Connection apparatus for optical coherence tomography catheters
US6661513B1 (en) 2001-11-21 2003-12-09 Roygbiv, Llc Refractive-diffractive spectrometer
EP1463441A4 (en) 2001-12-11 2009-01-21 C2Cure Inc Apparatus, method and system for intravascular photographic imaging
US20030216719A1 (en) 2001-12-12 2003-11-20 Len Debenedictis Method and apparatus for treating skin using patterns of optical energy
WO2003052883A2 (en) 2001-12-14 2003-06-26 Agilent Technologies, Inc. Retro-reflecting device in particular for tunable lasers
US7736301B1 (en) 2001-12-18 2010-06-15 Advanced Cardiovascular Systems, Inc. Rotatable ferrules and interfaces for use with an optical guidewire
US7365858B2 (en) 2001-12-18 2008-04-29 Massachusetts Institute Of Technology Systems and methods for phase measurements
US6947787B2 (en) 2001-12-21 2005-09-20 Advanced Cardiovascular Systems, Inc. System and methods for imaging within a body lumen
US6975891B2 (en) 2001-12-21 2005-12-13 Nir Diagnostics Inc. Raman spectroscopic system with integrating cavity
EP1324051A1 (en) 2001-12-26 2003-07-02 Kevin R. Forrester Motion measuring device
US20080154090A1 (en) 2005-01-04 2008-06-26 Dune Medical Devices Ltd. Endoscopic System for In-Vivo Procedures
EP1468245B1 (en) 2002-01-11 2011-03-30 The General Hospital Corporation Apparatus for OCT imaging with axial line focus for improved resolution and depth of field
US7072045B2 (en) 2002-01-16 2006-07-04 The Regents Of The University Of California High resolution optical coherence tomography with an improved depth range using an axicon lens
EP1470410B1 (en) 2002-01-24 2012-01-11 The General Hospital Corporation Apparatus and method for rangings and noise reduction of low coherence interferometry (lci) and optical coherence tomography (oct) signals by parallel detection of spectral bands
US7355716B2 (en) 2002-01-24 2008-04-08 The General Hospital Corporation Apparatus and method for ranging and noise reduction of low coherence interferometry LCI and optical coherence tomography OCT signals by parallel detection of spectral bands
RU2240502C1 (en) 2002-02-14 2004-11-20 Феликс Исаакович Фельдштейн Method for analysis of object and optical interferometer for realization of said method
US20030165263A1 (en) 2002-02-19 2003-09-04 Hamer Michael J. Histological assessment
US7116887B2 (en) 2002-03-19 2006-10-03 Nufern Optical fiber
US7006232B2 (en) 2002-04-05 2006-02-28 Case Western Reserve University Phase-referenced doppler optical coherence tomography
US7113818B2 (en) 2002-04-08 2006-09-26 Oti Ophthalmic Technologies Inc. Apparatus for high resolution imaging of moving organs
US7016048B2 (en) 2002-04-09 2006-03-21 The Regents Of The University Of California Phase-resolved functional optical coherence tomography: simultaneous imaging of the stokes vectors, structure, blood flow velocity, standard deviation and birefringence in biological samples
US20030236443A1 (en) 2002-04-19 2003-12-25 Cespedes Eduardo Ignacio Methods and apparatus for the identification and stabilization of vulnerable plaque
US7503904B2 (en) 2002-04-25 2009-03-17 Cardiac Pacemakers, Inc. Dual balloon telescoping guiding catheter
JP4135551B2 (en) 2002-05-07 2008-08-20 松下電工株式会社 Position sensor
JP3834789B2 (en) 2002-05-17 2006-10-18 独立行政法人科学技術振興機構 Autonomous ultra-short optical pulse compression, phase compensation, waveform shaping device
AU2003245458A1 (en) 2002-06-12 2003-12-31 Advanced Research And Technology Institute, Inc. Method and apparatus for improving both lateral and axial resolution in ophthalmoscopy
US7272252B2 (en) 2002-06-12 2007-09-18 Clarient, Inc. Automated system for combining bright field and fluorescent microscopy
US20040039252A1 (en) 2002-06-27 2004-02-26 Koch Kenneth Elmon Self-navigating endotracheal tube
JP3621693B2 (en) 2002-07-01 2005-02-16 フジノン株式会社 Interferometer device
WO2004006751A2 (en) 2002-07-12 2004-01-22 Volker Westphal Method and device for quantitative image correction for optical coherence tomography
JP3950378B2 (en) 2002-07-19 2007-08-01 新日本製鐵株式会社 Synchronous machine
JP4258015B2 (en) 2002-07-31 2009-04-30 毅 椎名 Ultrasonic diagnostic system, strain distribution display method, and elastic modulus distribution display method
US7283247B2 (en) 2002-09-25 2007-10-16 Olympus Corporation Optical probe system
AU2003272667A1 (en) 2002-09-26 2004-04-19 Bio Techplex Corporation Method and apparatus for screening using a waveform modulated led
US6842254B2 (en) 2002-10-16 2005-01-11 Fiso Technologies Inc. System and method for measuring an optical path difference in a sensing interferometer
CN100401994C (en) 2002-10-18 2008-07-16 阿里耶·谢尔 Atherectomy system with imaging guidewire
US20040092829A1 (en) 2002-11-07 2004-05-13 Simon Furnish Spectroscope with modified field-of-view
JP4246986B2 (en) 2002-11-18 2009-04-02 株式会社町田製作所 Vibration object observation system and vocal cord observation processing apparatus
US6847449B2 (en) 2002-11-27 2005-01-25 The United States Of America As Represented By The Secretary Of The Navy Method and apparatus for reducing speckle in optical coherence tomography images
EP1426799A3 (en) 2002-11-29 2005-05-18 Matsushita Electric Industrial Co., Ltd. Optical demultiplexer, optical multi-/demultiplexer, and optical device
DE10260256B9 (en) 2002-12-20 2007-03-01 Carl Zeiss Interferometer system and measuring / machining tool
GB0229734D0 (en) 2002-12-23 2003-01-29 Qinetiq Ltd Grading oestrogen and progesterone receptors expression
JP4148771B2 (en) 2002-12-27 2008-09-10 株式会社トプコン Laser device for medical machine
US7123363B2 (en) 2003-01-03 2006-10-17 Rose-Hulman Institute Of Technology Speckle pattern analysis method and system
EP1596716B1 (en) 2003-01-24 2014-04-30 The General Hospital Corporation System and method for identifying tissue using low-coherence interferometry
US7075658B2 (en) 2003-01-24 2006-07-11 Duke University Method for optical coherence tomography imaging with molecular contrast
US7643153B2 (en) 2003-01-24 2010-01-05 The General Hospital Corporation Apparatus and method for ranging and noise reduction of low coherence interferometry LCI and optical coherence tomography OCT signals by parallel detection of spectral bands
US6943892B2 (en) 2003-01-29 2005-09-13 Sarnoff Corporation Instrument having a multi-mode optical element and method
JP4338412B2 (en) 2003-02-24 2009-10-07 Hoya株式会社 Confocal probe and confocal microscope
US7271918B2 (en) 2003-03-06 2007-09-18 Zygo Corporation Profiling complex surface structures using scanning interferometry
EP1611470B1 (en) * 2003-03-31 2015-10-14 The General Hospital Corporation Speckle reduction in optical coherence tomography by path length encoded angular compounding
US7110109B2 (en) 2003-04-18 2006-09-19 Ahura Corporation Raman spectroscopy system and method and specimen holder therefor
JP4135550B2 (en) 2003-04-18 2008-08-20 日立電線株式会社 Semiconductor light emitting device
JP2004317437A (en) 2003-04-18 2004-11-11 Olympus Corp Optical imaging apparatus
WO2004098396A2 (en) 2003-05-01 2004-11-18 The Cleveland Clinic Foundation Method and apparatus for measuring a retinal sublayer characteristic
CA2536969C (en) 2003-05-05 2009-09-29 D4D Technologies, L.P. Optical coherence tomography imaging
CN101785656B (en) 2003-05-12 2012-08-15 富士胶片株式会社 Balloon controller for a balloon type endoscope
SE527164C2 (en) 2003-05-14 2006-01-10 Spectracure Ab Interactive therapy/diagnosis system for tumor, has operation mode selector to optically direct non-ionizing electromagnetic therapeutic and/or diagnostic radiation to tumor site, through radiation conductor
US7376455B2 (en) 2003-05-22 2008-05-20 Scimed Life Systems, Inc. Systems and methods for dynamic optical imaging
US7697145B2 (en) 2003-05-28 2010-04-13 Duke University System for fourier domain optical coherence tomography
EP1627248A4 (en) 2003-05-29 2008-06-04 Univ Michigan Double-clad fiber scanning microscope
WO2004111661A2 (en) 2003-05-30 2004-12-23 Duke University System and method for low coherence broadband quadrature interferometry
US6943881B2 (en) 2003-06-04 2005-09-13 Tomophase Corporation Measurements of optical inhomogeneity and other properties in substances using propagation modes of light
US7263394B2 (en) * 2003-06-04 2007-08-28 Tomophase Corporation Coherence-gated optical glucose monitor
EP2008579B1 (en) 2003-06-06 2016-11-09 The General Hospital Corporation Process and apparatus for a wavelength tuned light source
US7458683B2 (en) 2003-06-16 2008-12-02 Amo Manufacturing Usa, Llc Methods and devices for registering optical measurement datasets of an optical system
US7170913B2 (en) 2003-06-19 2007-01-30 Multiwave Photonics, Sa Laser source with configurable output beam characteristics
US20040260182A1 (en) 2003-06-23 2004-12-23 Zuluaga Andres F. Intraluminal spectroscope with wall contacting probe
JP4677208B2 (en) 2003-07-29 2011-04-27 オリンパス株式会社 Confocal microscope
US7307734B2 (en) 2003-08-14 2007-12-11 University Of Central Florida Interferometric sensor for characterizing materials
US7539530B2 (en) 2003-08-22 2009-05-26 Infraredx, Inc. Method and system for spectral examination of vascular walls through blood during cardiac motion
US20050083534A1 (en) * 2003-08-28 2005-04-21 Riza Nabeel A. Agile high sensitivity optical sensor
JP2005077964A (en) 2003-09-03 2005-03-24 Fujitsu Ltd Spectroscope apparatus
US20050059894A1 (en) 2003-09-16 2005-03-17 Haishan Zeng Automated endoscopy device, diagnostic method, and uses
US20050057680A1 (en) 2003-09-16 2005-03-17 Agan Martin J. Method and apparatus for controlling integration time in imagers
US7935055B2 (en) 2003-09-19 2011-05-03 Siemens Medical Solutions Usa, Inc. System and method of measuring disease severity of a patient before, during and after treatment
US6949072B2 (en) 2003-09-22 2005-09-27 Infraredx, Inc. Devices for vulnerable plaque detection
US8172747B2 (en) 2003-09-25 2012-05-08 Hansen Medical, Inc. Balloon visualization for traversing a tissue wall
US7142835B2 (en) 2003-09-29 2006-11-28 Silicon Laboratories, Inc. Apparatus and method for digital image correction in a receiver
US7292792B2 (en) 2003-09-30 2007-11-06 Lucent Technologies Inc. High speed modulation of optical subcarriers
JP5567246B2 (en) 2003-10-27 2014-08-06 ザ ジェネラル ホスピタル コーポレイション Method and apparatus for performing optical imaging using frequency domain interferometry
DE10351319B4 (en) 2003-10-31 2005-10-20 Med Laserzentrum Luebeck Gmbh Interferometer for optical coherence tomography
US7130320B2 (en) 2003-11-13 2006-10-31 Mitutoyo Corporation External cavity laser with rotary tuning element
EP1687587B1 (en) 2003-11-28 2020-01-08 The General Hospital Corporation Method and apparatus for three-dimensional spectrally encoded imaging
US7359062B2 (en) * 2003-12-09 2008-04-15 The Regents Of The University Of California High speed spectral domain functional optical coherence tomography and optical doppler tomography for in vivo blood flow dynamics and tissue structure
DE10358735B4 (en) 2003-12-15 2011-04-21 Siemens Ag Catheter device comprising a catheter, in particular an intravascular catheter
US7145661B2 (en) 2003-12-31 2006-12-05 Carl Zeiss Meditec, Inc. Efficient optical coherence tomography (OCT) system and method for rapid imaging in three dimensions
JP4414771B2 (en) 2004-01-08 2010-02-10 オリンパス株式会社 Confocal microspectroscope
JP4462959B2 (en) 2004-02-25 2010-05-12 富士通株式会社 Microscope image photographing system and method
WO2005082225A1 (en) 2004-02-27 2005-09-09 Optiscan Pty Ltd Optical element
US7190464B2 (en) * 2004-05-14 2007-03-13 Medeikon Corporation Low coherence interferometry for detecting and characterizing plaques
US7242480B2 (en) 2004-05-14 2007-07-10 Medeikon Corporation Low coherence interferometry for detecting and characterizing plaques
EP1754016B1 (en) 2004-05-29 2016-05-18 The General Hospital Corporation Process, system and software arrangement for a chromatic dispersion compensation using reflective layers in optical coherence tomography (oct) imaging
WO2006014392A1 (en) 2004-07-02 2006-02-09 The General Hospital Corporation Endoscopic imaging probe comprising dual clad fibre
DE102004035269A1 (en) 2004-07-21 2006-02-16 Rowiak Gmbh Laryngoscope with OCT
EP1782020B1 (en) 2004-08-06 2012-10-03 The General Hospital Corporation Process, system and software arrangement for determining at least one location in a sample using an optical coherence tomography
WO2006020605A2 (en) 2004-08-10 2006-02-23 The Regents Of The University Of California Device and method for the delivery and/or elimination of compounds in tissue
EP1787105A2 (en) 2004-09-10 2007-05-23 The General Hospital Corporation System and method for optical coherence imaging
JP4997112B2 (en) * 2004-09-29 2012-08-08 ザ ジェネラル ホスピタル コーポレイション Apparatus for transmitting at least one electromagnetic radiation and method of manufacturing the same
US7113625B2 (en) 2004-10-01 2006-09-26 U.S. Pathology Labs, Inc. System and method for image analysis of slides
SE0402435L (en) 2004-10-08 2006-04-09 Trajan Badju Process and system for generating three-dimensional images
EP1819270B1 (en) 2004-10-29 2012-12-19 The General Hospital Corporation Polarization-sensitive optical coherence tomography
WO2006050453A1 (en) 2004-11-02 2006-05-11 The General Hospital Corporation Fiber-optic rotational device, optical system and method for imaging a sample
US7417740B2 (en) 2004-11-12 2008-08-26 Medeikon Corporation Single trace multi-channel low coherence interferometric sensor
US8617152B2 (en) 2004-11-15 2013-12-31 Medtronic Ablation Frontiers Llc Ablation system with feedback
GB0425419D0 (en) 2004-11-18 2004-12-22 Sira Ltd Interference apparatus and method and probe
WO2006058187A2 (en) 2004-11-23 2006-06-01 Robert Eric Betzig Optical lattice microscopy
GB0426609D0 (en) 2004-12-03 2005-01-05 Ic Innovations Ltd Analysis
JP2006162366A (en) 2004-12-06 2006-06-22 Fujinon Corp Optical tomographic imaging system
US7450242B2 (en) 2004-12-10 2008-11-11 Fujifilm Corporation Optical tomography apparatus
US7336366B2 (en) 2005-01-20 2008-02-26 Duke University Methods and systems for reducing complex conjugate ambiguity in interferometric data
US7330270B2 (en) 2005-01-21 2008-02-12 Carl Zeiss Meditec, Inc. Method to suppress artifacts in frequency-domain optical coherence tomography
US7342659B2 (en) 2005-01-21 2008-03-11 Carl Zeiss Meditec, Inc. Cross-dispersed spectrometer in a spectral domain optical coherence tomography system
HU227859B1 (en) 2005-01-27 2012-05-02 E Szilveszter Vizi Real-time 3d nonlinear microscope measuring system and its application
US7267494B2 (en) 2005-02-01 2007-09-11 Finisar Corporation Fiber stub for cladding mode coupling reduction
US7860555B2 (en) 2005-02-02 2010-12-28 Voyage Medical, Inc. Tissue visualization and manipulation system
US7664300B2 (en) 2005-02-03 2010-02-16 Sti Medical Systems, Llc Uterine cervical cancer computer-aided-diagnosis (CAD)
US7649160B2 (en) 2005-02-23 2010-01-19 Lyncee Tec S.A. Wave front sensing method and apparatus
JP4628820B2 (en) 2005-02-25 2011-02-09 サンテック株式会社 Wavelength scanning fiber laser light source
US7530948B2 (en) 2005-02-28 2009-05-12 University Of Washington Tethered capsule endoscope for Barrett's Esophagus screening
DE102005010790A1 (en) 2005-03-09 2006-09-14 Basf Ag Photovoltaic cell with a photovoltaically active semiconductor material contained therein
US20060224053A1 (en) 2005-03-30 2006-10-05 Skyline Biomedical, Inc. Apparatus and method for non-invasive and minimally-invasive sensing of venous oxygen saturation and pH levels
KR20080013919A (en) 2005-04-22 2008-02-13 더 제너럴 하스피탈 코포레이션 Arrangements, systems and methods capable of providing spectral-domain polarization-sensitive optical coherence tomography
US9599611B2 (en) 2005-04-25 2017-03-21 Trustees Of Boston University Structured substrates for optical surface profiling
US20070009935A1 (en) 2005-05-13 2007-01-11 The General Hospital Corporation Arrangements, systems and methods capable of providing spectral-domain optical coherence reflectometry for a sensitive detection of chemical and biological sample
JP4709278B2 (en) 2005-05-23 2011-06-22 エフ. ヘスス ハラルド Optical microscopy using optically convertible optical labels
EP1887926B1 (en) 2005-05-31 2014-07-30 The General Hospital Corporation System and method which use spectral encoding heterodyne interferometry techniques for imaging
EP1889037A2 (en) 2005-06-01 2008-02-20 The General Hospital Corporation Apparatus, method and system for performing phase-resolved optical frequency domain imaging
US7391520B2 (en) 2005-07-01 2008-06-24 Carl Zeiss Meditec, Inc. Fourier domain optical coherence tomography employing a swept multi-wavelength laser and a multi-channel receiver
WO2007005913A2 (en) 2005-07-01 2007-01-11 Infotonics Technology Center, Inc. Non-invasive monitoring system
DE102005034443A1 (en) 2005-07-22 2007-02-22 Carl Zeiss Jena Gmbh Sample e.g. cell particle, luminescence microscopy method, involves prevailing one of sample regions for image of sample, so that image has local resolution which is enhanced in relation to excitation radiation distribution
JP4376837B2 (en) 2005-08-05 2009-12-02 サンテック株式会社 Wavelength scanning laser light source
US7668342B2 (en) 2005-09-09 2010-02-23 Carl Zeiss Meditec, Inc. Method of bioimage data processing for revealing more meaningful anatomic features of diseased tissues
WO2007030835A2 (en) 2005-09-10 2007-03-15 Baer Stephen C High resolution microscopy using an optically switchable fluorophore
US8114581B2 (en) 2005-09-15 2012-02-14 The Regents Of The University Of California Methods and compositions for detecting neoplastic cells
KR100743591B1 (en) 2005-09-23 2007-07-27 한국과학기술원 Confocal Self-Interference Microscopy Which Excluding Side Lobes
CN101304683B (en) 2005-09-29 2012-12-12 通用医疗公司 Method and apparatus for method for viewing and analyzing of one or more biological samples with progressively increasing resolutions
US7450241B2 (en) 2005-09-30 2008-11-11 Infraredx, Inc. Detecting vulnerable plaque
US7400410B2 (en) 2005-10-05 2008-07-15 Carl Zeiss Meditec, Inc. Optical coherence tomography for eye-length measurement
WO2007044612A2 (en) 2005-10-07 2007-04-19 Bioptigen, Inc. Imaging systems using unpolarized light and related methods and controllers
US7595889B2 (en) 2005-10-11 2009-09-29 Duke University Systems and methods for endoscopic angle-resolved low coherence interferometry
WO2007044786A2 (en) 2005-10-11 2007-04-19 Zygo Corporation Interferometry method and system including spectral decomposition
US7408649B2 (en) 2005-10-26 2008-08-05 Kla-Tencor Technologies Corporation Method and apparatus for optically analyzing a surface
US8145018B2 (en) 2006-01-19 2012-03-27 The General Hospital Corporation Apparatus for obtaining information for a structure using spectrally-encoded endoscopy techniques and methods for producing one or more optical arrangements
US20070223006A1 (en) 2006-01-19 2007-09-27 The General Hospital Corporation Systems and methods for performing rapid fluorescence lifetime, excitation and emission spectral measurements
US9087368B2 (en) 2006-01-19 2015-07-21 The General Hospital Corporation Methods and systems for optical imaging or epithelial luminal organs by beam scanning thereof
GB0601183D0 (en) 2006-01-20 2006-03-01 Perkinelmer Ltd Improvements in and relating to imaging
WO2007090147A2 (en) 2006-01-31 2007-08-09 The Board Of Trustees Of The University Of Illinois Method and apparatus for measurement of optical properties in tissue
JP5519152B2 (en) 2006-02-08 2014-06-11 ザ ジェネラル ホスピタル コーポレイション Device for acquiring information about anatomical samples using optical microscopy
US8184367B2 (en) 2006-02-15 2012-05-22 University Of Central Florida Research Foundation Dynamically focused optical instrument
DE102006008990B4 (en) 2006-02-23 2008-05-21 Atmos Medizintechnik Gmbh & Co. Kg Method and arrangement for generating a signal corresponding to the opening state of the vocal folds of the larynx
JP2007271761A (en) 2006-03-30 2007-10-18 Fujitsu Ltd Spectrometer and wavelength dispersion controller
EP2004041B1 (en) 2006-04-05 2013-11-06 The General Hospital Corporation Methods, arrangements and systems for polarization-sensitive optical frequency domain imaging of a sample
WO2007127395A2 (en) 2006-04-28 2007-11-08 Bioptigen, Inc. Methods, systems and computer program products for optical coherence tomography (oct) using automatic dispersion compensation
WO2007133964A2 (en) 2006-05-12 2007-11-22 The General Hospital Corporation Processes, arrangements and systems for providing a fiber layer thickness map based on optical coherence tomography images
EP1859727A1 (en) 2006-05-26 2007-11-28 Stichting voor de Technische Wetenschappen optical triggering system for stroboscopy and a stroboscopic system
US7599074B2 (en) 2006-06-19 2009-10-06 The Board Of Trustees Of The Leland Stanford Junior University Grating angle magnification enhanced angular sensor and scanner
US20070291277A1 (en) 2006-06-20 2007-12-20 Everett Matthew J Spectral domain optical coherence tomography system
WO2008027927A2 (en) 2006-08-28 2008-03-06 Thermo Electron Scientific Instruments Llc Spectroscopic microscopy with image -driven analysis
US8838213B2 (en) 2006-10-19 2014-09-16 The General Hospital Corporation Apparatus and method for obtaining and providing imaging information associated with at least one portion of a sample, and effecting such portion(s)
US20080138011A1 (en) 2006-10-26 2008-06-12 Furukawa Electric North America, Inc. Production of optical pulses at a desired wavelength utilizing higher-order-mode (HOM) fiber
JP2010508056A (en) 2006-10-30 2010-03-18 エルフィ−テック リミテッド System and method for in vivo measurement of biological parameters
DE102006054556A1 (en) 2006-11-20 2008-05-21 Zimmer Medizinsysteme Gmbh Apparatus and method for non-invasive, optical detection of chemical and physical blood values and body constituents
US20080204762A1 (en) 2007-01-17 2008-08-28 Duke University Methods, systems, and computer program products for removing undesired artifacts in fourier domain optical coherence tomography (FDOCT) systems using integrating buckets
US7911621B2 (en) 2007-01-19 2011-03-22 The General Hospital Corporation Apparatus and method for controlling ranging depth in optical frequency domain imaging
JP5227525B2 (en) 2007-03-23 2013-07-03 株式会社日立製作所 Biological light measurement device
US8222385B2 (en) 2007-03-26 2012-07-17 National University Corporation Tokyo University of Marine Science Technology Germ cell marker using fish vasa gene
US8244334B2 (en) 2007-04-10 2012-08-14 University Of Southern California Methods and systems for blood flow measurement using doppler optical coherence tomography
US8115919B2 (en) 2007-05-04 2012-02-14 The General Hospital Corporation Methods, arrangements and systems for obtaining information associated with a sample using optical microscopy
US8166967B2 (en) 2007-08-15 2012-05-01 Chunyuan Qiu Systems and methods for intubation
US20090219544A1 (en) 2007-09-05 2009-09-03 The General Hospital Corporation Systems, methods and computer-accessible medium for providing spectral-domain optical coherence phase microscopy for cell and deep tissue imaging
JP2011500173A (en) 2007-10-12 2011-01-06 ザ ジェネラル ホスピタル コーポレイション System and process for optical imaging of luminal anatomical structures
US9332942B2 (en) 2008-01-28 2016-05-10 The General Hospital Corporation Systems, processes and computer-accessible medium for providing hybrid flourescence and optical coherence tomography imaging
JP5192247B2 (en) 2008-01-29 2013-05-08 並木精密宝石株式会社 OCT probe
US7898656B2 (en) 2008-04-30 2011-03-01 The General Hospital Corporation Apparatus and method for cross axis parallel spectroscopy
US8184298B2 (en) 2008-05-21 2012-05-22 The Board Of Trustees Of The University Of Illinois Spatial light interference microscopy and fourier transform light scattering for cell and tissue characterization
JP5324839B2 (en) 2008-06-19 2013-10-23 株式会社トプコン Optical image measuring device
JP5546112B2 (en) 2008-07-07 2014-07-09 キヤノン株式会社 Ophthalmic imaging apparatus and ophthalmic imaging method
US8133127B1 (en) 2008-07-21 2012-03-13 Synder Terrance W Sports training device and methods of use
US8457715B2 (en) 2009-04-08 2013-06-04 Covidien Lp System and method for determining placement of a tracheal tube
US20120228523A1 (en) 2009-11-09 2012-09-13 Tata Institute Of Fundamental Research Biological laser plasma x-ray point source

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11727534B2 (en) 2020-12-08 2023-08-15 International Business Machines Corporation Normalizing OCT image data

Also Published As

Publication number Publication date
US20100157309A1 (en) 2010-06-24
AU2004225188B2 (en) 2010-04-15
JP5571621B2 (en) 2014-08-13
US20130314716A1 (en) 2013-11-28
US9226665B2 (en) 2016-01-05
WO2004088361A2 (en) 2004-10-14
US20120281237A1 (en) 2012-11-08
WO2004088361A3 (en) 2005-04-07
US8174702B2 (en) 2012-05-08
JP2011209293A (en) 2011-10-20
JP2006522341A (en) 2006-09-28
US8559012B2 (en) 2013-10-15
CA2519937A1 (en) 2004-10-14
EP1611470A4 (en) 2009-06-17
EP1611470A2 (en) 2006-01-04
AU2004225188A1 (en) 2004-10-14
US7567349B2 (en) 2009-07-28
EP2436307B1 (en) 2015-10-21
JP4805142B2 (en) 2011-11-02
US20060227333A1 (en) 2006-10-12
EP2436307A1 (en) 2012-04-04
EP1611470B1 (en) 2015-10-14

Similar Documents

Publication Publication Date Title
CA2519937C (en) Speckle reduction in optical coherence tomography by path length encoded angular compounding
US7515265B2 (en) Imaging systems and methods to improve backscattering imaging using circular polarization memory
JP2016209182A (en) Imaging device, method for operating imaging device, information processor, and method for operating information processor
JP2015102537A (en) Optical interference tomograph meter
KR101053222B1 (en) Optical Coherence Tomography Device Using Multi-line Camera
WO2012002302A1 (en) Optical tomographic imaging device and optical tomographic imaging method
Jørgensen et al. Speckle reduction in optical coherence tomography images of human skin by a spatial diversity method
Wang et al. Optical coherence tomography for noninvasive diagnosis of epithelial cancers
Nteroli et al. Developments on using supercontinuum sources for high resolution multi-imaging instruments for biomedical applications
WO2012014920A1 (en) Optical tomographic imaging system and optical tomographic imaging method
Fujimoto et al. Optical coherence tomography
Latrive et al. Flexible and rigid endoscopy for high-resolution in-depth imaging with Full-Field OCT
Dubois High-resolution optical coherence tomography Application in dermatology
Iftimia et al. Analysis of Speckle Reduction in Optical Coherence Tomography by Path Length Encoded Angular Compounding
Herz et al. Micro-motor endoscope with adjustable focus for ultrahigh resolution OCT
Gelikonov et al. A decade of optical coherence tomography in Russia: from experiment to clinical practice
Yuan et al. Optical coherence tomography for bladder cancer diagnosis: from animal study to clinical diagnosis
De Li et al. OCT imaging of osteoarthritic cartilage: structure, polarization sensitivity, and clinical feasibility
Makhlouf et al. A dual modality fluorescence confocal and optical coherence tomography microendoscope
Latrive et al. Full-Field OCM for Endoscopy
Abraham et al. High Speed Imaging of Biological Tissues by Use of Coherence or Temporal Optical Gating
Wang et al. Interpixel-Shifted Endoscopic Optical Coherence Tomography for In Vivo Bladder Cancer Diagnosis
Chen et al. High-speed imaging system based on spectral optical coherence tomography
Mahon et al. ON THE HORIZON–HIGH AND ULTRAHIGH RESOLUTION BRONCHOSCOPIC OCT IMAGING
Kredzinski et al. 1550 nm superluminescent diode and anti-Stokes effect CCD camera based optical coherence tomography for full-field optical metrology

Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed

Effective date: 20160331