CA2530136A1 - In-situ gelling drug delivery system - Google Patents
In-situ gelling drug delivery system Download PDFInfo
- Publication number
- CA2530136A1 CA2530136A1 CA002530136A CA2530136A CA2530136A1 CA 2530136 A1 CA2530136 A1 CA 2530136A1 CA 002530136 A CA002530136 A CA 002530136A CA 2530136 A CA2530136 A CA 2530136A CA 2530136 A1 CA2530136 A1 CA 2530136A1
- Authority
- CA
- Canada
- Prior art keywords
- composition
- polyethylene glycol
- aqueous fluid
- drug substance
- polymer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000012377 drug delivery Methods 0.000 title claims abstract 6
- 238000011065 in-situ storage Methods 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 claims abstract 24
- 239000002202 Polyethylene glycol Substances 0.000 claims abstract 10
- 229920001223 polyethylene glycol Polymers 0.000 claims abstract 10
- 229920000642 polymer Polymers 0.000 claims abstract 10
- 239000008186 active pharmaceutical agent Substances 0.000 claims abstract 9
- 229940088679 drug related substance Drugs 0.000 claims abstract 9
- 238000000034 method Methods 0.000 claims 12
- 239000012530 fluid Substances 0.000 claims 9
- 239000000499 gel Substances 0.000 claims 4
- DZOXUIJDHVERIU-UHFFFAOYSA-N 2-(2-hydroxypropanoyloxy)acetic acid Polymers CC(O)C(=O)OCC(O)=O DZOXUIJDHVERIU-UHFFFAOYSA-N 0.000 claims 2
- 239000007975 buffered saline Substances 0.000 claims 2
- 229940126523 co-drug Drugs 0.000 claims 2
- BQJCRHHNABKAKU-KBQPJGBKSA-N morphine Chemical compound O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O BQJCRHHNABKAKU-KBQPJGBKSA-N 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 229940051841 polyoxyethylene ether Drugs 0.000 claims 2
- 229920000056 polyoxyethylene ether Polymers 0.000 claims 2
- 102000004196 processed proteins & peptides Human genes 0.000 claims 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims 2
- 229940002612 prodrug Drugs 0.000 claims 2
- 239000000651 prodrug Substances 0.000 claims 2
- 238000013268 sustained release Methods 0.000 claims 2
- 239000012730 sustained-release form Substances 0.000 claims 2
- 108091006006 PEGylated Proteins Proteins 0.000 claims 1
- DCOPUUMXTXDBNB-UHFFFAOYSA-N diclofenac Chemical compound OC(=O)CC1=CC=CC=C1NC1=C(Cl)C=CC=C1Cl DCOPUUMXTXDBNB-UHFFFAOYSA-N 0.000 claims 1
- 229960001259 diclofenac Drugs 0.000 claims 1
- 239000000017 hydrogel Substances 0.000 claims 1
- 229960005181 morphine Drugs 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 238000013270 controlled release Methods 0.000 abstract 2
- 239000003844 drug implant Substances 0.000 abstract 1
- 238000002347 injection Methods 0.000 abstract 1
- 239000007924 injection Substances 0.000 abstract 1
- 239000007788 liquid Substances 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/382—Heterocyclic compounds having sulfur as a ring hetero atom having six-membered rings, e.g. thioxanthenes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/55—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug, i.e. a dimer, oligomer or polymer of pharmacologically or therapeutically active compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6903—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being semi-solid, e.g. an ointment, a gel, a hydrogel or a solidifying gel
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
- A61K9/0051—Ocular inserts, ocular implants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0092—Hollow drug-filled fibres, tubes of the core-shell type, coated fibres, coated rods, microtubules or nanotubes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Abstract
The invention provides liquid controlled-release drug delivery compositions which gel upon injection into the body to form, in situ, controlled-release drug implants. The compositions of the invention feature a gel-forming polymer that is insoluble in water, a polyethylene glycol solvent in which the polymer is dissolved, and the drug substance to be delivered.
Claims (31)
1. An injectable pharmaceutical composition comprising:
(a) a drug substance;
(b) a polyethylene glycol; and (c) a biocompatible and bioerodable poly(DL-lactide-glycolide) (PLGA) polymer;
wherein the bioerodable PLGA polymer is dissolved, dispersed or suspended in the polyethylene glycol.
(a) a drug substance;
(b) a polyethylene glycol; and (c) a biocompatible and bioerodable poly(DL-lactide-glycolide) (PLGA) polymer;
wherein the bioerodable PLGA polymer is dissolved, dispersed or suspended in the polyethylene glycol.
2. The composition of claim 1, wherein the average MW of the polyethylene glycol is between about 100 and about 6000.
3. The composition of claim 2, wherein the average MW of the polyethylene glycol is between about 200 and about 400.
4. The composition of any one of claims 1-3, wherein the drug substance is dissolved in the polyethylene glycol.
5. The composition of any one of claims 1-3, wherein the PLGA polymer is dissolved in the polyethylene glycol.
6. The composition of claim 4, wherein the PLGA polymer is dissolved in the polyethylene glycol.
7. A composition according to any one of claims 1-6, wherein the drug substance is selected from the group consisting of peptides, proteins, pegylated peptides, and pegylated proteins.
8. A composition according to any one of claims 1-6, wherein the drug substance is a prodrug.
9. A composition according to any one of claims 1-6, wherein the drug substance is a co-drug.
10. A composition according to claim 9, wherein the co-drug comprises morphine linked to diclofenac.
11. A method for administering a drug substance to a subject, comprising injecting into the subject a composition according to any one of claims 1-10.
12. A method for forming a polymeric sustained-release drug delivery gel in a subject, comprising injecting into the subject a composition according to any one of claims 1-10.
13. A method of administering a composition according to claims 1-10 wherein the composition is co-administered with an aqueous fluid.
14. The method according to claim 13 wherein the aqueous fluid is buffered saline.
15. The method according to claim 13 wherein the aqueous fluid is a hydrogel.
16. The method according to claim 13 wherein the aqueous fluid and the composition are administered via a double lumen needle.
17. The method according to claim 15 wherein the aqueous fluid and the composition are administered via a double lumen syringe.
18. The method according to claim 13 wherein the aqueous fluid and the polymer gel are mixed immediately before administration.
19. The method according to claim 15 wherein the aqueous fluid and the polymer gel are each contained in a separate syringe.
20. A drug delivery device containing a composition according to any one of claims 1-10.
21. A device according to claim 20 wherein the device has at least one opening.
22. A device according to claim 20 wherein the device is an open tube.
23. An injectable pharmaceutical composition comprising:
(a) a prodrug, comprising a drug substance covalently linked to a polyoxyethylene ether; and (b) a biocompatible and bioerodable poly(DL-lactide-glycolide) (PLGA) polymer;
wherein the bioerodable PLGA polymer is dissolved, dispersed or suspended in the drug substance - polyoxyethylene ether complex.
(a) a prodrug, comprising a drug substance covalently linked to a polyoxyethylene ether; and (b) a biocompatible and bioerodable poly(DL-lactide-glycolide) (PLGA) polymer;
wherein the bioerodable PLGA polymer is dissolved, dispersed or suspended in the drug substance - polyoxyethylene ether complex.
24. The composition of claim 23, wherein the average MW of the polyethylene glycol is between about 100 and about 6000.
25. The composition of claim 23, wherein the average MW of the polyethylene glycol is between about 200 and about 400.
26. A method for forming a polymeric sustained-release drug delivery gel in a subject, comprising injecting into the subject a composition according to any one of claims 23-25.
27. A method of administering a composition according to claims 23-25 wherein the composition is co-administered with an aqueous fluid.
28. The method according to claim 27 wherein the aqueous fluid is buffered saline.
29. A drug delivery device containing a composition according to any one of claims 23-25.
30. A device according to claim 29 wherein the device has at least one opening.
31. A device according to claim 29 wherein the device is an open tube.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US48267703P | 2003-06-26 | 2003-06-26 | |
US60/482,677 | 2003-06-26 | ||
US57530704P | 2004-05-28 | 2004-05-28 | |
US60/575,307 | 2004-05-28 | ||
PCT/US2004/020369 WO2005002625A2 (en) | 2003-06-26 | 2004-06-25 | In-situ gelling drug delivery system |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2530136A1 true CA2530136A1 (en) | 2005-01-13 |
CA2530136C CA2530136C (en) | 2012-10-16 |
Family
ID=33567657
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA2530136A Expired - Fee Related CA2530136C (en) | 2003-06-26 | 2004-06-25 | In-situ gelling drug delivery system |
Country Status (16)
Country | Link |
---|---|
US (4) | US20050048123A1 (en) |
EP (2) | EP1635875B8 (en) |
JP (1) | JP5229768B2 (en) |
CN (2) | CN1863557B (en) |
AR (1) | AR044926A1 (en) |
AT (1) | ATE410186T1 (en) |
CA (1) | CA2530136C (en) |
CY (1) | CY1108685T1 (en) |
DE (1) | DE602004016995D1 (en) |
DK (1) | DK1635875T3 (en) |
ES (1) | ES2315680T3 (en) |
PL (1) | PL1635875T3 (en) |
PT (1) | PT1635875E (en) |
SI (1) | SI1635875T1 (en) |
TW (1) | TWI377958B (en) |
WO (1) | WO2005002625A2 (en) |
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US20040208910A1 (en) * | 2000-04-26 | 2004-10-21 | Control Delivery Systems, Inc. | Sustained release device and method for ocular delivery of adrenergic agents |
JP2006511475A (en) * | 2002-09-18 | 2006-04-06 | トラスティーズ オブ ザ ユニバーシティ オブ ペンシルベニア | Method for suppressing choroidal neovascular disease |
US7585517B2 (en) * | 2003-09-18 | 2009-09-08 | Macusight, Inc. | Transscleral delivery |
SI1848431T1 (en) | 2005-02-09 | 2016-05-31 | Santen Pharmaceutical Co., Ltd. | Liquid formulations for treatment of diseases or conditions |
US8663639B2 (en) * | 2005-02-09 | 2014-03-04 | Santen Pharmaceutical Co., Ltd. | Formulations for treating ocular diseases and conditions |
US8852638B2 (en) | 2005-09-30 | 2014-10-07 | Durect Corporation | Sustained release small molecule drug formulation |
JP5528708B2 (en) | 2006-02-09 | 2014-06-25 | 参天製薬株式会社 | Stable formulations and methods for preparing and using them |
US8222271B2 (en) * | 2006-03-23 | 2012-07-17 | Santen Pharmaceutical Co., Ltd. | Formulations and methods for vascular permeability-related diseases or conditions |
JP4827626B2 (en) * | 2006-06-14 | 2011-11-30 | キヤノン株式会社 | CONTROLLED DEVICE, REMOTE CONTROL SYSTEM, REMOTE CONTROL SYSTEM CONTROL METHOD, PROGRAM |
GB0701896D0 (en) | 2007-02-01 | 2007-03-14 | Regentec Ltd | Composition |
US20080265343A1 (en) * | 2007-04-26 | 2008-10-30 | International Business Machines Corporation | Field effect transistor with inverted t shaped gate electrode and methods for fabrication thereof |
NZ581862A (en) | 2007-05-25 | 2012-06-29 | Tolmar Therapeutics Inc | Injectable subcutaneous formulation comprising risperidone capable of forming a solid, microporous implant in a patient |
WO2009120358A1 (en) * | 2008-03-27 | 2009-10-01 | Nektar Therapeutics | Oligomer-nitrogenous base conjugates |
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US9125917B2 (en) * | 2008-04-18 | 2015-09-08 | Warsaw Orthopedic, Inc. | Fluocinolone formulations in a biodegradable polymer carrier |
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KR20140015266A (en) * | 2010-11-24 | 2014-02-06 | 듀렉트 코퍼레이션 | Biodegradable drug delivery composition |
JP2014521636A (en) * | 2011-07-27 | 2014-08-28 | ポリピッド リミテッド | Matrix composition for controlled release of peptide and polypeptide molecules |
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-
2004
- 2004-06-25 JP JP2006517646A patent/JP5229768B2/en not_active Expired - Fee Related
- 2004-06-25 SI SI200430994T patent/SI1635875T1/en unknown
- 2004-06-25 PT PT04756068T patent/PT1635875E/en unknown
- 2004-06-25 AR ARP040102252A patent/AR044926A1/en not_active Application Discontinuation
- 2004-06-25 WO PCT/US2004/020369 patent/WO2005002625A2/en active Application Filing
- 2004-06-25 TW TW093118700A patent/TWI377958B/en not_active IP Right Cessation
- 2004-06-25 CA CA2530136A patent/CA2530136C/en not_active Expired - Fee Related
- 2004-06-25 PL PL04756068T patent/PL1635875T3/en unknown
- 2004-06-25 ES ES04756068T patent/ES2315680T3/en active Active
- 2004-06-25 CN CN2004800237331A patent/CN1863557B/en not_active Expired - Fee Related
- 2004-06-25 DE DE602004016995T patent/DE602004016995D1/en active Active
- 2004-06-25 DK DK04756068T patent/DK1635875T3/en active
- 2004-06-25 EP EP04756068A patent/EP1635875B8/en not_active Not-in-force
- 2004-06-25 US US10/877,758 patent/US20050048123A1/en not_active Abandoned
- 2004-06-25 EP EP08017574A patent/EP2044959A1/en not_active Withdrawn
- 2004-06-25 CN CN201010165296A patent/CN101862455A/en active Pending
- 2004-06-25 AT AT04756068T patent/ATE410186T1/en active
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2008
- 2008-12-19 CY CY20081101469T patent/CY1108685T1/en unknown
-
2010
- 2010-08-27 US US12/870,616 patent/US20110165242A1/en not_active Abandoned
-
2012
- 2012-09-12 US US13/612,076 patent/US20130101656A1/en not_active Abandoned
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2014
- 2014-07-28 US US14/444,338 patent/US9566336B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
JP5229768B2 (en) | 2013-07-03 |
EP1635875B8 (en) | 2008-12-24 |
CA2530136C (en) | 2012-10-16 |
ATE410186T1 (en) | 2008-10-15 |
CY1108685T1 (en) | 2014-04-09 |
US20050048123A1 (en) | 2005-03-03 |
PL1635875T3 (en) | 2009-03-31 |
JP2007524628A (en) | 2007-08-30 |
TW200514581A (en) | 2005-05-01 |
AR044926A1 (en) | 2005-10-12 |
EP2044959A1 (en) | 2009-04-08 |
CN1863557A (en) | 2006-11-15 |
US20130101656A1 (en) | 2013-04-25 |
TWI377958B (en) | 2012-12-01 |
EP1635875A2 (en) | 2006-03-22 |
US20140336278A1 (en) | 2014-11-13 |
CN101862455A (en) | 2010-10-20 |
DE602004016995D1 (en) | 2008-11-20 |
WO2005002625A3 (en) | 2005-04-21 |
US20110165242A1 (en) | 2011-07-07 |
SI1635875T1 (en) | 2009-04-30 |
ES2315680T3 (en) | 2009-04-01 |
CN1863557B (en) | 2010-06-16 |
US9566336B2 (en) | 2017-02-14 |
WO2005002625A2 (en) | 2005-01-13 |
PT1635875E (en) | 2008-12-09 |
EP1635875B1 (en) | 2008-10-08 |
DK1635875T3 (en) | 2009-01-12 |
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