CA2535833A1 - Method and apparatus for assay of electrochemical properties - Google Patents
Method and apparatus for assay of electrochemical properties Download PDFInfo
- Publication number
- CA2535833A1 CA2535833A1 CA002535833A CA2535833A CA2535833A1 CA 2535833 A1 CA2535833 A1 CA 2535833A1 CA 002535833 A CA002535833 A CA 002535833A CA 2535833 A CA2535833 A CA 2535833A CA 2535833 A1 CA2535833 A1 CA 2535833A1
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- CA
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- Prior art keywords
- analyte
- potential
- current
- electrodes
- sample
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/487—Physical analysis of biological material of liquid biological material
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/1486—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using enzyme electrodes, e.g. with immobilised oxidase
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/1495—Calibrating or testing of in-vivo probes
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/001—Enzyme electrodes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/001—Enzyme electrodes
- C12Q1/004—Enzyme electrodes mediator-assisted
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/001—Enzyme electrodes
- C12Q1/005—Enzyme electrodes involving specific analytes or enzymes
- C12Q1/006—Enzyme electrodes involving specific analytes or enzymes for glucose
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/28—Electrolytic cell components
- G01N27/30—Electrodes, e.g. test electrodes; Half-cells
- G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
- G01N27/3271—Amperometric enzyme electrodes for analytes in body fluids, e.g. glucose in blood
- G01N27/3274—Corrective measures, e.g. error detection, compensation for temperature or hematocrit, calibration
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/416—Systems
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/416—Systems
- G01N27/4166—Systems measuring a particular property of an electrolyte
- G01N27/4168—Oxidation-reduction potential, e.g. for chlorination of water
Abstract
The presence of a select analyte in the sample is evaluated in an electrochemical system using a conduction cell-type apparatus. A potential o r current is generated between the two electrodes of the cell sufficient to bring about oxidation or reduction of the analyte or of a mediator in an analyte-detection redox system, thereby forming a chemical potential gradien t of the analyte or mediator between the two electrodes. After the gradient is established, the applied potential or current is discontinued and an analyte - independent signal is obtained from the relaxation of the chemical potential gradient. The analyte-independent signal is used to correct the analyte- dependent signal obtained during application of the potential or current. Th is correction allows an improved measurement of analyte concentration because i t corrects for device-specific and test specific factors such as transport (mobility) of analyte and/or mediator, effective electrode area, and electro de spacing (and as a result, sample volume), without need for separate calibration values. The analysis can be performed using disposable test stri ps in a hand held meter, for example for glucose testing.
Claims (17)
1. A method of evaluating a sample far the presence of a select analyte comprising the steps of:
(a) introducing the sample into a space between two electrodes of a conduction cell;
(b) applying a potential or current between the two electrodes sufficient to bring about oxidation or reduction of the analyte or of a mediator in an analyte-detection redox system, thereby forming a chemical potential gradient of the analyte or mediator between the two electrodes; .
(c) after the gradient is established, discontinuing the applied potential or current and obtaining an analyte-independent signal reflecting relaxation of the chemical potential gradient;
(d) optionally applying a potential or current between the electrodes after the analyte-independent signal is obtained;
(e) obtaining an analyze-dependent signal during the application of the potential or current in step (b) or step (d) or both, and (f) correcting the analyte-dependent signal obtained in step (e) using the analyte-independent signal obtained in step (c) to obtain a corrected analyte-dependent signal indicative of the presence of the selected analyte in the sample.
(a) introducing the sample into a space between two electrodes of a conduction cell;
(b) applying a potential or current between the two electrodes sufficient to bring about oxidation or reduction of the analyte or of a mediator in an analyte-detection redox system, thereby forming a chemical potential gradient of the analyte or mediator between the two electrodes; .
(c) after the gradient is established, discontinuing the applied potential or current and obtaining an analyte-independent signal reflecting relaxation of the chemical potential gradient;
(d) optionally applying a potential or current between the electrodes after the analyte-independent signal is obtained;
(e) obtaining an analyze-dependent signal during the application of the potential or current in step (b) or step (d) or both, and (f) correcting the analyte-dependent signal obtained in step (e) using the analyte-independent signal obtained in step (c) to obtain a corrected analyte-dependent signal indicative of the presence of the selected analyte in the sample.
2. The method of claim 1, wherein a potential is applied between the electrodes in step (b), and current generated as a result of this applied potential is measured as the analyte-dependent signal.
3. The method of claim 2, wherein the potential is applied until a steady state condition is achieved, and the current is then measured.
4. The method of claim 2, wherein the current is measured before a steady state condition is achieved.
5. The method of claim 1, wherein a current is maintained between the electrodes in step (b), and potential generated as a result of this current is measured as the analyte- dependent signal.
6. The method of claim 5, wherein the current is maintained until a steady state condition is achieved, and the potential is then measured.
7. The method of claim 5, wherein the potential is measured before a steady state condition is achieved.
8. The method of any of claims 1 to 7, wherein the chemical potential gradient prior to relaxation extends across at least 10% of the distance between the electrodes.
9. The method of claim 8, wherein the chemical potential gradient prior to relaxation extends across at least 80% of the distance between the electrodes.
10. The method of any of claims 1 to 9, wherein the sample is a blood sample and the select analyte is glucose.
11. A method for determining the effective separation distance between a first electrode and a second electrode in an electrochemical cell, the method comprising the steps of:
applying an external force in the form of an applied potential or an applied current to generate a chemical potential gradient in a liquid disposed between the first electrode and the second electrode;
stopping the application of the external force;
observing the decay of the chemical potential gradient as a function of time;
and computing the effective electrode separation distance from the observed decay of the chemical potential gradient.
applying an external force in the form of an applied potential or an applied current to generate a chemical potential gradient in a liquid disposed between the first electrode and the second electrode;
stopping the application of the external force;
observing the decay of the chemical potential gradient as a function of time;
and computing the effective electrode separation distance from the observed decay of the chemical potential gradient.
12. A method for determining an effective transport property of a species in a liquid sample disposed between a first electrode and a second electrode in an electrochemical cell, the method comprising the steps of:
applying an external force in the form of an applied potential or a current to generate a chemical potential gradient in the liquid sample between the first electrode and the second electrode;
stopping the application of the external force;
observing the decay of the chemical potential gradient as a function of time;
and computing an effective transport property of the species in the electrochemical system from the observed decay of the chemical potential gradient.
applying an external force in the form of an applied potential or a current to generate a chemical potential gradient in the liquid sample between the first electrode and the second electrode;
stopping the application of the external force;
observing the decay of the chemical potential gradient as a function of time;
and computing an effective transport property of the species in the electrochemical system from the observed decay of the chemical potential gradient.
13. The method of any of claims 1 to 12, wherein the electrodes are part of a single use disposable test strip.
14. An apparatus for determining the presence of an analyte in a sample disposed in an electrochemical cell said electrochemical cell comprising two electrodes between which the sample is placed for analysis, said apparatus comprising:
(a) a housing having a space for receiving the electrochemical cell;
(b) means for applying a potential or a current between the two electrodes of the electrochemical cell when it is received within the housing;
(c) means for measuring oxidation or reduction of an analyte or a mediator in an analyte-detection system occurring within the electrochemical cell when the potential or current is being applied;
(d) means for switching the potential or current off after a period of time during which a chemical potential gradient is established between the two electrodes;
(e) means for monitoring the decay of the chemical potential gradient after the potential or current is switched off;
programmed data processing means for combining the measured oxidation or reduction with the monitored decay to produce an indication of the presence of the analyte in the sample; and (g) output means for conveying the indication of the presence of the analyte in the sample to a user.
(a) a housing having a space for receiving the electrochemical cell;
(b) means for applying a potential or a current between the two electrodes of the electrochemical cell when it is received within the housing;
(c) means for measuring oxidation or reduction of an analyte or a mediator in an analyte-detection system occurring within the electrochemical cell when the potential or current is being applied;
(d) means for switching the potential or current off after a period of time during which a chemical potential gradient is established between the two electrodes;
(e) means for monitoring the decay of the chemical potential gradient after the potential or current is switched off;
programmed data processing means for combining the measured oxidation or reduction with the monitored decay to produce an indication of the presence of the analyte in the sample; and (g) output means for conveying the indication of the presence of the analyte in the sample to a user.
15. The apparatus of claim 14, further comprising an electrochemical cell disposed within the housing.
16. The apparatus of claim 15, wherein the electrochemical cell is a single use disposable test strip.
17. The apparatus of any of claims 14 to 16, wherein the housing is of a size that can be held in a human hand.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA2804931A CA2804931C (en) | 2003-08-21 | 2004-08-23 | Method and apparatus for assay of electrochemical properties |
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US49678703P | 2003-08-21 | 2003-08-21 | |
US60/496,787 | 2003-08-21 | ||
US52964803P | 2003-12-15 | 2003-12-15 | |
US60/529,648 | 2003-12-15 | ||
PCT/US2004/027441 WO2005022143A2 (en) | 2003-08-21 | 2004-08-23 | Method and apparatus for assay of electrochemical properties |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA2804931A Division CA2804931C (en) | 2003-08-21 | 2004-08-23 | Method and apparatus for assay of electrochemical properties |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2535833A1 true CA2535833A1 (en) | 2005-03-10 |
CA2535833C CA2535833C (en) | 2013-11-26 |
Family
ID=34278536
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA2535833A Active CA2535833C (en) | 2003-08-21 | 2004-08-23 | Method and apparatus for assay of electrochemical properties |
Country Status (12)
Country | Link |
---|---|
US (5) | US7501052B2 (en) |
EP (2) | EP2589960A1 (en) |
JP (1) | JP5022033B2 (en) |
KR (1) | KR101114020B1 (en) |
CN (1) | CN1867826B (en) |
AU (2) | AU2004268222B2 (en) |
BR (1) | BRPI0413213A (en) |
CA (1) | CA2535833C (en) |
ES (1) | ES2709991T3 (en) |
HK (1) | HK1099075A1 (en) |
MX (1) | MXPA06001914A (en) |
WO (1) | WO2005022143A2 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN114544725A (en) * | 2020-11-25 | 2022-05-27 | 五鼎生物技术股份有限公司 | Biochemical test piece |
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US7501052B2 (en) | 2009-03-10 |
US20050109637A1 (en) | 2005-05-26 |
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