CN101084038B - 肾神经调节的装置 - Google Patents

肾神经调节的装置 Download PDF

Info

Publication number
CN101084038B
CN101084038B CN2005800417112A CN200580041711A CN101084038B CN 101084038 B CN101084038 B CN 101084038B CN 2005800417112 A CN2005800417112 A CN 2005800417112A CN 200580041711 A CN200580041711 A CN 200580041711A CN 101084038 B CN101084038 B CN 101084038B
Authority
CN
China
Prior art keywords
electrode
kidney
conduit
electric field
nerve
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN2005800417112A
Other languages
English (en)
Other versions
CN101084038A (zh
Inventor
马克·迪姆
汉森·吉尔福德·三世
丹尼斯·德马雷
道格拉斯·萨顿
埃里克·塔尔
马克·盖尔劳德
霍华德·R·莱文
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Medtronic Adian LLC
Medtronic Ardian Luxembourg SARL
Medtronic Ardian LLC
Original Assignee
Ardian Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37889643&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CN101084038(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ardian Inc filed Critical Ardian Inc
Priority to CN201010279054.8A priority Critical patent/CN101972513B/zh
Publication of CN101084038A publication Critical patent/CN101084038A/zh
Application granted granted Critical
Publication of CN101084038B publication Critical patent/CN101084038B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
    • A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
    • A61B18/14—Probes or electrodes therefor
    • A61B18/1492—Probes or electrodes therefor having a flexible, catheter-like structure, e.g. for heart ablation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
    • A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
    • A61B18/1206—Generators therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
    • A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
    • A61B18/1206—Generators therefor
    • A61B18/1233—Generators therefor with circuits for assuring patient safety
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/08—Detecting organic movements or changes, e.g. tumours, cysts, swellings
    • A61B8/0891—Detecting organic movements or changes, e.g. tumours, cysts, swellings for diagnosis of blood vessels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/12—Diagnosis using ultrasonic, sonic or infrasonic waves in body cavities or body tracts, e.g. by using catheters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/0021—Catheters; Hollow probes characterised by the form of the tubing
    • A61M25/0023—Catheters; Hollow probes characterised by the form of the tubing by the form of the lumen, e.g. cross-section, variable diameter
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A61N1/0551—Spinal or peripheral nerve electrodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/20—Applying electric currents by contact electrodes continuous direct currents
    • A61N1/205—Applying electric currents by contact electrodes continuous direct currents for promoting a biological process
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/327—Applying electric currents by contact electrodes alternating or intermittent currents for enhancing the absorption properties of tissue, e.g. by electroporation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/36007—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation of urogenital or gastrointestinal organs, e.g. for incontinence control
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/36014—External stimulators, e.g. with patch electrodes
    • A61N1/36017—External stimulators, e.g. with patch electrodes with leads or electrodes penetrating the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/36057—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for stimulating afferent nerves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/3606—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
    • A61N1/36103—Neuro-rehabilitation; Repair or reorganisation of neural tissue, e.g. after stroke
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/3606—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
    • A61N1/36114—Cardiac control, e.g. by vagal stimulation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/36128—Control systems
    • A61N1/36135—Control systems using physiological parameters
    • A61N1/36139—Control systems using physiological parameters with automatic adjustment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00053—Mechanical features of the instrument of device
    • A61B2018/00059—Material properties
    • A61B2018/00071—Electrical conductivity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00053—Mechanical features of the instrument of device
    • A61B2018/00214—Expandable means emitting energy, e.g. by elements carried thereon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00053—Mechanical features of the instrument of device
    • A61B2018/00214—Expandable means emitting energy, e.g. by elements carried thereon
    • A61B2018/0022—Balloons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00053—Mechanical features of the instrument of device
    • A61B2018/00214—Expandable means emitting energy, e.g. by elements carried thereon
    • A61B2018/00267—Expandable means emitting energy, e.g. by elements carried thereon having a basket shaped structure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00315—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
    • A61B2018/00345—Vascular system
    • A61B2018/00404—Blood vessels other than those in or around the heart
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00315—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
    • A61B2018/00434—Neural system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00315—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
    • A61B2018/00505—Urinary tract
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00315—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
    • A61B2018/00505—Urinary tract
    • A61B2018/00511—Kidney
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00571—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for achieving a particular surgical effect
    • A61B2018/00577—Ablation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00571—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for achieving a particular surgical effect
    • A61B2018/00613—Irreversible electroporation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00636—Sensing and controlling the application of energy
    • A61B2018/00642—Sensing and controlling the application of energy with feedback, i.e. closed loop control
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00636—Sensing and controlling the application of energy
    • A61B2018/00904—Automatic detection of target tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
    • A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
    • A61B18/1206—Generators therefor
    • A61B2018/1246—Generators therefor characterised by the output polarity
    • A61B2018/126—Generators therefor characterised by the output polarity bipolar
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
    • A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
    • A61B18/14—Probes or electrodes therefor
    • A61B2018/1467—Probes or electrodes therefor using more than two electrodes on a single probe
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0408—Use-related aspects
    • A61N1/0412—Specially adapted for transcutaneous electroporation, e.g. including drug reservoirs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/326—Applying electric currents by contact electrodes alternating or intermittent currents for promoting growth of cells, e.g. bone cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/3606—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
    • A61N1/36114—Cardiac control, e.g. by vagal stimulation
    • A61N1/36117—Cardiac control, e.g. by vagal stimulation for treating hypertension
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A61N2007/0004—Applications of ultrasound therapy
    • A61N2007/0021—Neural system treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A61N2007/0004—Applications of ultrasound therapy
    • A61N2007/0021—Neural system treatment
    • A61N2007/003—Destruction of nerve tissue

Abstract

本发明提供了用于肾神经调节的方法和装置，其使用脉冲电场进行电穿孔或电融合。除了别的以外，预计肾神经调节作用(例如，去除神经作用)可以减少急性心肌梗塞的扩张，减少或防止与充血性心力衰竭相关的形态学变化的发作，和/或有效用于肾病晚期的治疗。本发明的实施方案设置成经皮血管内输送脉冲电场以实现这样的神经调节作用。

Description

肾神经调节的装置
相关申请的交叉参考
本申请要求于2004年10月5日提交的美国临时专利申请序列号60/616,254，和于2004年11月2日提交的序列号60/624,793的提出日的利益；二者通过参考完全结合于此。此外，本申请是于2003年4月8日提交的同时待审的美国专利申请序列号10/408,665的部分继续申请，所述申请在2003年11月20日公布为美国专利申请2003/0216792，并且其要求于2002年4月8日提交的美国临时专利申请序列号60/370,190，于2002年10月3日提交的序列号60/415,575，和于2003年1月29日提交的序列号60/442,970的提出日的利益；所有这些临时申请通过参考完全结合于此。
参考文献的结合
本说明书中提及的所有出版物和专利申请通过参考以相同的程度并入本申请，就象每一单独的出版物或专利申请具体地并且独立地结合而作为参考。
技术领域
本发明涉及肾神经调节的方法和装置。更具体地，本发明涉及通过脉冲电场和/或电穿孔或电融合获得肾神经调节的方法和装置。
背景
充血性心力衰竭(“CHF”)是当心脏受到损伤并且减少供应机体器官的血流时发生的一种病症。如果血流充分减少，那么肾功能将受到损害，并且导致流体滞留、异常的激素分泌和增加的血管收缩。这些结果增加了心脏的负担，并且进一步减少心脏通过肾和循环系统泵血的能力。
这种减少的能力进一步减少流向肾脏的血液，其又进一步减少心脏的能力。据信，肾脏的逐渐减少的灌注是使得CHF下行螺旋永续的主要非心脏因素。此外，流体负担和由这些生理变化导致的相关临床症状是由于CHF引起的过多的入院、很坏的生活质量和卫生保健系统的过重的成本的主要因素。
尽管起初有许多不同的疾病可以损伤心脏，但是一旦存在，CHF分成两种类型：慢性CHF和急性(或代偿失调-慢性)CHF。慢性充血性心力衰竭是一种长期的、缓慢发展的变性疾病。几年后，慢性充血性心力衰竭导致心机能不全。慢性CHF临床上由患者锻炼或者进行正常的日常生活活动的能力(诸如由New York Heart Association Functional Class定义的那样)而分类。慢性CHF患者通常基于门诊典型地用药进行应付。
慢性CHF患者可能经历心脏功能的突发的严重退化，叫作急性充血性心力衰竭，这导致心脏没有能力维持充足的血流和压力来保持机体重要器官的存活。在稳定的慢性CHF患者中，当额外的压力(诸如感染或过多的流体负担)显著地增加心脏负担时，可能发生这些急性CHF退化。与慢性CHF的逐步的下行发展相反，患有急性CHF的患者可能从甚至是CHF的最早阶段退化到严重的血液动力崩溃。另外，急性CHF可以在急性心肌梗塞(“AMI”)后的几个小时或几天内发生，所述急性心肌梗塞是对于心肌的突发的、不可复原的损伤，通常叫作心脏病发作。
如提及的那样，肾脏在CHF的发展中，以及在慢性肾衰竭(“CRF”)、晚期肾病(“ESRD”)、高血压(疾病引起的高血压)以及其它心-肾疾病中起着重要作用。肾脏功能可以在3个主要方面进行总结：滤过血液并且排泄机体新陈代谢产生的废物；调控盐、水、电解质和酸碱平衡；并且分泌激素维持重要器官的血流。没有正确行使功能的肾脏，那么患者将患有水滞留，减少的尿流，并且在血液和机体内累积废物毒素。据信，由减少的肾功能或肾衰竭(肾衰)导致的这些病症增加心脏负担。在CHF患者中，由于弱功能性肾脏引起的水的积聚和血液毒素累积，肾衰竭将引起心脏进一步退化，并且又将引起心脏进一步损坏。
肾脏参与尿形成的主要功能单位叫作“肾单位”。每个肾由大约一百万个肾单位组成。肾单位由肾小球及其肾小管组成，肾小管可以分成许多部分：近端小管，髓襻(亨利袢)和远端小管。每个肾单位由不同类型的细胞围绕，所述细胞具有分泌一些物质和激素(诸如肾素和促红细胞生成素)的能力。尿的形成是从将血浆水分滤过到肾小球中起始的复杂的过程的结果。肾小球的壁对于水和小分子是自由通透的，而对于蛋白和大分子几乎不可通透。因此，在健康的肾脏中，滤过物几乎没有蛋白，并且没有细胞成分。最后变成尿的滤过的流体流过导管。尿的最后的化学组成由尿保持动态平衡所需要的物质的分泌和重吸收而确定。
接收大约20％的心脏输出，两个肾脏每分钟过滤大约125ml的血浆水。滤过由于跨越肾小球膜的压力梯度而发生。肾脏动脉中的压力推动血浆水穿过肾小球，而引起滤过。为了保持肾小球滤过速率(“GFR”)相对稳定，肾小球的压力通过传入和传出微动脉的收缩或扩张而保持恒定，所述传入和传出微动脉的肌肉壁管进出每个肾小球。
在CHF患者中，心脏日益衰竭，并且在患者的循环系统中血流和压力将下降。在急性心力衰竭中，短期补偿提供保持主要器官灌注的作用，特别是保持长期缺少血流不能存活的大脑和心脏的灌注。然而，这些最初在急性心力衰竭中辅助存活的相同的反应在慢性心力衰竭过程中是有害的。
复杂机制的组合构成CHF中有害的流体超负荷。由于心脏衰竭和血压下降，肾脏不能行使功能，并且由于不足的灌注血压而受到损害。肾功能的这种损害最终导致尿输出量的减少。没有充分的尿输出，机体保留流体，并且在患者中其它的不理想病症中，所引起的流体超负荷引起末梢水肿(腿的水肿)、呼吸短缺(由于肺部的流体)、和腹部流体滞留。
另外，心脏输出的减少导致减少的肾脏血流，增加的神经激素刺激，并且从肾脏的肾小球旁器释放激素肾素。这导致钠的急剧滞留，并且因此导致体积膨胀。增加的肾素导致形成血管紧张素，一种有效的血管收缩剂。心力衰竭和引起的血压减少还减少通过除肾脏外的机体器官的血流和灌注压。由于它们遭受减少的血压，这些器官可能缺氧，引起代谢性酸中毒，这减少药物治疗的效力并且增加突发死亡的危险。
据信，医生在心力衰竭患者中观察到的退化的这种螺旋至少部分受到心脏功能和肾脏功能之间的微细相互作用的激活的调控，所述相互作用叫作肾素-血管紧张素系统。心脏泵血功能的干扰导致减少的心脏输出和减少的血流。肾脏响应减少的血流就好像总的血液体积减少了一样，实际上此时检测的体积是正常的或者甚至是增加的。这引起肾脏的流体滞留，并且形成水肿，因而引起流体超负荷和关于心脏的增加的压力。
系统地，CHF与异常升高的外周血管阻力相关，并且受到由于交感神经系统功能的强烈干扰引起的循环改变的控制。增加的交感神经系统活性促进这样的恶性循环，即，增加的动脉血管收缩(增加的血管对血流的阻力)，然后进一步减少心脏输出，这引起更多减少的流向重要器官的血液。
在先前通过血管收缩机制解释的CHF中，心脏和循环系统显著地减少流向肾脏的血液。在CHF过程中，肾脏通过神经途径和激素信使从高级神经中枢得到命令，保留机体内的流体和钠。应答对于心脏的压力，神经中枢命令肾脏减少它们的滤过功能。尽管在短期内，这些命令可能是有利的，如果这些命令持续几个小时和几天，它们可能通过使得肾脏停止起作用而危害个体的生命，或者使得个体依赖人工肾脏维持生命。
当肾脏不完全过滤血液时，大量的流体滞留在机体内，这导致肿胀(组织中流体滞留)，并且增加心脏负担。流体可以透到肺部，并且患者变得呼吸短缺。这种奇怪的和自我-破坏性现象最可能由机体的正常补偿机制而解释，所述机体错误地将CHF的慢性的缓慢血压感知为临时干扰诸如流血的征兆。
在急性情形中，机体尝试保护其最重要的器官，脑和心脏，免受氧气匮乏的危险。命令通过神经和激素途径和信使传出。这些命令针对维持脑和心脏的血压的目的，脑和心脏由机体视为最重要的器官。脑和心脏不能持续低灌注任何基本的时间阶段。如果这些器官的血压减少到不可接受的水平，那么将引起中风或心搏停止。其它的器官，诸如肾脏，可以经受稍微长期的缺血而不会遭受长期的损害。因此，为了支持脑和心脏，机体牺牲对这些其它器官的血液供应。
CHF引起的血液动力学损害激活一些神经激素系统，诸如肾素-血管紧张素和醛固酮系统、交感-肾上腺系统和血管升压素的释放。由于肾脏遭受增加的肾血管收缩，所以GFR下降，并且循环系统中钠的负荷增加。同时，更多的肾素从肾脏的近肾小球释放。减少的肾功能的组合作用包括减少的肾小球钠负荷，醛固酮-介导的钠管式重吸收的增加，以及钠和水分在机体内的滞留。这些作用导致一些CHF病症的迹象和症状，包括扩大的心脏、增加的收缩壁压、增加的心肌氧需求、以及基于流体和钠在肾脏中的滞留形成水肿。因此，持续减少的肾血流和血管收缩是引起与CHF相关的流体滞留的直接原因。
CHF是日益加重的，并且到目前还是不可治愈的。药物治疗的局限及其没有能力逆转或者甚至是阻止CHF患者的恶化是显而易见的。在一些情形中，手术治疗是有效的，但是由于相关的危险和费用，仅限于末期患者群体。此外，肾脏在CHF患者恶化中的显著作用不能由目前的手术治疗充分地阐明。
自主神经系统被视作重要的信号控制途径，其负责调控对于维持血管流体平衡和血压重要的机体功能。自主神经系统以信号的形式将来自机体生物传感器诸如压力感受器(应答压力和血液体积)和化学感受器(应答血液的化学组合物)的信息通过其感觉纤维传导到中枢神经系统。它还通过其运动纤维传导来自中枢神经系统的命令信号，所述命令信号控制血管系统的受神经支配的各种成分。
关于人肾脏植入的经验提供了关于神经系统在肾脏功能中的作用的早期证据。注意到，植入后，当所有的肾脏神经完全起作用时，肾脏增加水和钠的排泄。当肾神经被切断或者化学破坏时，这一现象也在动物中观察到。由于去神经对肾脏的作用类似于利尿药物，所以，所述现象叫作“去神经利尿”。后来，发现“去神经利尿”与导致通过肾脏的增加的血流的肾动脉系统的血管舒张相关。这一观察得到在动物中下述观察的证实：减少的供应肾脏的血压逆转了“去神经利尿”。
还观察到，在成功病例植入手术过后的几个月后，植入受体的“去神经利尿”停止，并且肾功能恢复正常。最初，据信，“肾利尿”是暂时现象，并且将来自中枢神经系统的信号传导至肾脏的神经对于肾脏功能是不重要的。后来的发现表明，肾神经具有深刻的再生能力，并且“去神经利尿”的逆转可能归因于为肾脏提供必需的刺激的新的神经纤维的生长。
另一个研究团体集中在肾脏对激素肾素分泌的神经控制上。如先前所讨论的那样，肾素是负责心力衰竭患者中血管收缩和水与钠滞留的“恶性循环”的激素。证明肾交感神经活性的增加或减少分别在肾脏分泌肾素的速率中产生相应的增加和减少。
概括来说，从临床经验和大的动物研究团体可知，肾交感神经活性的增加导致供应肾脏的血管的血管收缩、减少的肾血流、减少的水和钠从机体的去除、以及增加的肾素分泌。还可知肾交感神经活性的减少，例如，通过去神经作用，可以逆转这些作用。
已经在动物模型中确定，心力衰竭病症导致肾脏异常高的交感刺激。这一现象追溯到将来自压力感受器的信号传导到中枢神经系统的感受神经。压力感受器存在于血管系统的不同位置。在颈动脉(为脑提供动脉血)的压力感受器和针对肾脏的交感神经刺激之间存在强有力的关系。当在患有心力衰竭的实验动物中，动脉血压力突然减小时，交感紧张增加。然而，在慢性CHF患者中，正常的压力反射可能不完全负责升高的肾神经活性。如果暴露于减少的动脉压力水平一段延长的时间，那么压力感受器通常“重新调定”，即，恢复到基线活性水平，直到引入新的干扰。因此，据信，在慢性CHF患者中，负责控制血压和肾脏功能神经控制的自主神经系统成分变得异常。虽然引起这种异常的准确机制没有得到充分理解，但是它对CHF患者综合病症的作用是深刻地阴性的。
晚期肾脏疾病(End-Stage Renal Disease)是至少部分由肾神经活性控制的另一种病症。由于糖尿病性肾病、慢性肾小球肾炎和不可控制的高血压，在患有ESRD的患者中存在显著的增加。慢性肾衰竭缓慢地发展成ESRD。CRF代表ESRD发展的关键时期。CRF的迹象和症状最初是很小的，但是经过2-5年的过程，变得日益严重并且不可恢复。尽管在与ESRD进展和并发症的抗争中已经取得了一些进展，但是现有发明的临床益处是有限的。
几十年来已经知道，不同病因(低血压、感染、外伤、自体免疫疾病等)的肾病可以导致CRF综合征，其特征在于系统性的高血压、蛋白尿(过量的蛋白从血液过滤到尿中)和日益下降的GFR，最终导致ESRD。这些观察表明，CRF通过常规机制途径发展，并且不管起始的原因，抑制这一常规途径的治疗干预可以成功地减缓CRF的发展。
为了起始CRF恶性循环，肾脏的初始损伤引起一些肾单位的丢失。为了保持正常的GFR，存在在剩余的肾单位中导致超滤状态的补偿性肾脏和系统机制的激活。然而，最后，越来越多数目的“过度工作的”并且受到超滤损坏的肾单位丢失。在某种程度上，失去足够数目的肾单位，以致不再能够维持正常的GFR。CRF的这些病理变化产生恶化的系统性高血压，因而产生高肾小球压力和增加的超滤。CRF中增加的肾小球超滤和渗透性促使增加量的来自血液的蛋白穿过肾小球并且进入到肾小管中。这种蛋白对于小管有直接的毒性，并且导致肾单位的进一步损失，增加CRF的发展速度。由于GFR随着多余的肾单位的损失而下降，所以这种CRF的恶性循环持续，导致进一步的超滤，并且最终导致需要透析的ESRD。临床上，已经表明高血压和过量的蛋白过滤是CRF向ESRD发展速率中的两种主要决定因素。
尽管先前临床上就已经知道，但是直到20世纪80年代才确定了高血压、蛋白尿、肾单位丢失和CRF之间的生理学联系。在20世纪90年代，阐明了交感神经系统活性的作用。由于机械感受器和化学感受器的激活而产生于损伤肾脏的传入信号刺激大脑负责血压控制的区域。响应中，大脑增加关于系统水平的交感刺激，主要通过血管的血管收缩引起增加的血压。当升高的交感神经刺激通过传入交感神经纤维到达肾脏时，它产生两种形式的主要恶化作用。肾脏受到来自肾脏中交感神经递质(诸如去甲肾上腺素)不依赖高血压的释放的直接肾脏毒性的损害。此外，激活血管紧张素II的肾素的分泌增加，其增加系统性血管收缩并且加剧高血压。
随着时间过去，肾脏的损伤导致从肾脏到大脑的传入交感信号的进一步增加。升高的血管紧张素II进一步促进内在的神经递质的肾释放。因此，反馈回路关闭，这加快了肾脏的恶化。
考虑到前文，有必要提供通过肾神经调节和/或去神经作用治疗充血性心力衰竭、肾病、高血压和/或其它心-肾疾病的方法和装置。
概述
本发明提供使用脉冲电场(PEF)进行肾神经调节(例如，去神经作用)的方法和装置。本发明的一些方面应用脉冲电场在肾神经、引起肾神经功能或其它肾特征的其它神经纤维中完成电穿孔和/或电融合。本发明的一些实施方案是诱导肾神经调节作用的血管内装置。本文所述的装置和方法可以应用实现神经调节包括去神经作用，和/或另外产生电穿孔和/或电融合作用的任何适当的电信号或场参数。例如，电信号可以结合纳秒脉冲电场(nsPEF)和/或PEF用于完成电穿孔。一个具体的实施方案包括应用第一过程的PEF电穿孔，然后第二过程的nsPEF电穿孔，以在PEF处理后保持完好的任何细胞中诱导凋亡，或者反之亦然。一个备选的实施方案包括以某种方式应用PEF而融合神经细胞，希望这可以减少或者消除神经传导电刺激的能力。当将所述方法和装置用于肾神经和/或引起肾神经功能的其它神经纤维时，本发明人相信，尿输出将增加和/或血压将以某种形式得到控制，这将预防或治疗CHF、高血压、肾系统疾病以及其它肾异常。
通过选择适当的PEFs和/或nsPEFs的参数，具体实施方案的一些方面可以实现这样的结果。脉冲电场参数可以包括，但不限于，场强、脉冲宽度、脉冲形状、脉冲数目和/或脉冲之间的时间间隔(例如，占空比)。例如，适宜的场强包括高达约10,000V/cm的强度。例如，适宜的脉冲宽度包括高达约1秒的宽度。例如，适宜的脉冲波形形状包括AC波形、正弦曲线波、余弦波、正弦和余弦波的组合、DC波形、DC-偏移AC波形、RF波形、方波、梯形波、指数衰减波、它们的组合等。例如，适宜的脉冲数目包括至少一个脉冲。例如，适宜的脉冲时间间隔包括小于大约10秒的间隔。当需要时，可以应用这些参数的任何组合。这些参数为了举例说明而提供，决不应该认为是限制。其它的和备选的波形参数应该是显而易见的。
一些实施方案针对经皮的血管内系统，用于提供长期持续的去神经作用以将急性心肌梗塞(“AMI”)扩展减到最少，并且用于帮助预防与充血性心力衰竭相关的形态变化的发作。例如，本发明的一个实施方案包括治疗患有梗塞的患者，例如，通过冠状血管成形术和/或支架(stenting)进行治疗，和在荧光镜指导下实行动脉内部脉冲电场肾去神经作用流程。备选地，在AMI稳定后不久，可以在独立的时间输送PEF治疗。肾神经调节作用还可以用作肾手术方法的辅助治疗。在这些实施方案中，预计由肾PEF治疗提供的尿输出的预计增加和/或血压的控制将减轻心脏负荷，从而抑制梗塞的扩展并且预防CHF。
本文所述的血管内脉冲电场系统的一些实施方案可以在梗塞后立即，或者在其后的任何时间，去除神经或者减少肾神经供应的活性，而不会在患者中留下永久的植入物。预计这些实施方案将在几个月的时期内增加尿输出和/或控制血压，在这段时期内患者的心脏可以治愈。如果确定在这一治愈期间后重复的和/或慢性神经调节将是有利的，那么可以根据需要重复肾PEF治疗。
除了有效地治疗AMI，本文所述的系统的一些实施方案还希望治疗CHF、高血压、肾衰竭、以及受增加的肾交感神经活性影响的其它肾脏或心-肾疾病。例如，所述系统可以随时用于治疗CHF，其通过血管结构将PEF系统推进到治疗位点，然后将PEF治疗输送到所述治疗位点而进行。例如，这可以改进流体清除的水平。
本文所述的血管内PEF系统的实施方案可以类似地用于本领域公知的血管成形术或电生理学导管。例如，通过标准塞尔丁格技术可以获得动脉通路，并且任选地可以放置动脉鞘以提供导管通路。导线(guidewire)可以通过血管系统向前推进，并且进入患者的肾动脉，然后血管内PEF可以沿着导线向前推进和/或通过所述鞘进入肾动脉。所述鞘任选地可以在插入PEF导管之前放置，或者与PEF导管一起向前推进，以便所述鞘部分地或完全地覆盖所述导管。备选地，PEF导管可以无需使用导线直接通过血管系统向前推进，和/或无需鞘而引入并且向前推进到血管系统中。
除了动脉放置，PEF系统可以放置在静脉内。例如，静脉通路可以通过颈静脉途径获得。例如，PEF系统可以用于肾动脉内、肾静脉内或者肾动脉和肾静脉二者内，以促进更完全的去除神经作用。
在将PEF导管置于关于靶点神经元的理想位置的血管内后，将它稳定在血管内部(例如，顶着血管壁稳定)，并且将能量输送到靶点神经或神经元。在一种变体中，将脉冲的RE能量输送到靶点，以产生非热量神经阻滞(non-thermal nerve block)，减少神经信号传导，或者另外调控神经活性。备选地或另外地，冷却的、低温的、热RF、热或非热微波、聚焦的或非聚焦的超声、热或非热DC以及它们的任何组合可以用来减少或者另外控制神经信号传导。
在本发明的另一个实施方案中，除了或者代替肾神经结构外，其它非肾神经结构可以靶向动脉或静脉管道内。例如，PEF导管可以通过大动脉或者腔静脉，并且开始与各种神经结果并列，以治疗其它病症或者增强肾脏-心脏病症的治疗。例如，腰部交感神经链的神经体(nerve bodies)可以以这种方式进入和调控，阻滞或切除等。
PEF系统的一些实施方案可以完全阻滞或者去除靶点神经结构的神经，或者PEF系统可以另外调控肾神经活性。由于与完全的神经阻滞诸如去除神经作用相反，其它神经调节作用在肾脏和其余机体之间的肾神经活性水平上产生小于完全的变化。因此，改变脉冲电场参数将对神经活性产生不同的作用。
在一个血管内脉冲电场系统的实施方案中，所述装置包括一个或多个电极，将其设置成与肾血管的靶点区域接触，以输送脉冲电场。例如，所述装置可以包括具有可扩张的螺旋部件的导管和在所述螺旋部件上的一个或多个电极。所述导管可以以不引人注意的构型位于肾血管内。然后，所述可扩张的部件可以扩张，以接触管壁的内表面。备选地，所述导管可以具有一个或多个可扩张的螺旋电极。例如，第一和第二可扩张的电极可以以彼此之间理想的距离位于管内，以提供作用电极和回流电极(returnelectrode)。可扩张的电极可以包括形状-记忆物质、膨胀气球、可扩大的网孔、连接系统、以及可以以可控方式扩大的其它类型的装置。适当扩大的连接系统包括可扩张的篮(expandable baskets)，其具有多个形状-记忆电线或开槽hypotubes、和/或可扩张的环。另外，所述可扩张的电极可以是沿着导管的气球部分排列的点接触电极。
脉冲电场的其它实施方案包括不与管壁物理接触的电极。RF能，传统热能和相对非热脉冲RF二者，是可以从距离组织本身的短距离传入要治疗的组织的脉冲电场的实例。其它类型的脉冲电场也可以用于其中电极与管壁没有物理接触的情形中。同样地，脉冲电场可以通过电极触头和管壁或其它组织之间的物理接触而直接应用于神经，或者脉冲电场可以无需电极触头与管壁的物理接触而间接用于神经。因此，术语“神经接触”包括系统元件与神经和/或紧接所述神经的组织的物理接触，以及没有与神经或组织的物理接触的单独的电接触。为了间接应用所述脉冲电场，所述装置具有定中心元件(centering element)，其被设置成将电极置于血管中心区域或者电极远离管壁的其它空间的中心区域。所述定中心元件可以包括，例如，气球或可扩张的篮。一个或多个电极可以位于定中心元件的中心轴上——与所述元件纵向排列或者位于所述元件的任一面上。当应用球导管时，膨胀的气球可以作为增加的阻抗的绝缘体，用于确定或者指导脉冲电场沿着理想的电流途径反向。显而易见地，可以应用备选的绝缘体。
在所述系统的另一个实施方案中，一种组合装置包括血管内导管，其具有设置成与管壁物理接触的第一电极，和设置成位于管内但在空间上远离管壁的第二电极。例如，可扩张的螺旋电极可以与中心倾向的电极组合，以提供这样的双极电极对。
在另一个实施方案中，可以将一个或多个电极相对于管壁的辐向位置进行动态改变，以聚焦由电极输送的脉冲电场。在另一种变化中，电极可以设置成部分或完全通过管壁。例如，电极可以位于肾静脉内，然后通过肾静脉壁进入血管周隙空间，以致它们在输送脉冲电场之前至少部分地环绕肾动脉和/或静脉。
本发明的双极性实施方案可以设置成相对于作用电极和接地电极之间的间距进行动态运动或操作，以实现通过理想距离、体积或其它维度的治疗。例如，可以安排多个电极，以便双极性电极对可以相对于彼此纵向移动，以调整电极之间分离的距离和/或改变治疗的位置。一个具体的实施方案包括偶联到导管上的第一电极，和可移动的第二电极，所述第二电极可以通过导管的内腔移动。在备选实施方案中，第一电极可以附着到导管上，并且第二电极可以附着到内腔-输送的(endoluminally-delivered)装置上，以致第一和第二电极可以相对于彼此重新定位，以改变电极之间的分离距离。这样的实施方案可以促进各种肾血管系统解剖学治疗。
本文所述的本发明的任何实施方案任选地可以设置成将试剂在能量应用之前、之中或之后灌注到治疗区域。可以选择灌注的试剂，以增强或改进能量应用的神经调节效果。所述试剂还可以保护或者临时转移非靶点细胞，和/或促进显现。
本发明的一些实施方案可以包括促进确定治疗位置和/或检测或证实治疗成功性的检测器或其它元件。例如，所述系统可以设置成还输送刺激波形，并且监测已知应答肾神经刺激的生理参数。基于所监测的参数的结果，所述系统可以确定肾神经的位置和/或去除神经作用是否发生。监测这样的生理反应的检测器包括，例如，多普勒元件、热电偶、压力传感器、和成像手段(例如，荧光镜透视、血管内部超声等)。备选地，例如，可以直接使用电阻抗体层摄影术(“EIT”)或者其它电阻抗检测法来监测电穿孔作用。其它的监测技术和元件是显而易见的。这样的检测器可以与PEF系统结合，或者它们可以是独立的元件。
另一个具体实施方案包括设置成将电场沿着靶点细胞的较长尺度排列的电极。例如，神经细胞倾向于延长结构，长度极大地超过它们的横向尺寸(例如，直径)。通过排列电场，以致场传播的方向性优先地影响细胞的纵向方面，而不是细胞的横向方面，预计可以应用更低的场强来杀死或者使得靶点细胞失去能力。这希望保持植入装置的电池寿命，减少对邻近结构的附属作用，并且另外增强调控靶点细胞神经活性的能力。
本发明的其它实施方案针对这样的应用，即，其中在神经之上或之下的组织中的细胞的纵向维度关于神经细胞的纵向方向是横向的(例如，垂直或者另外以某种角度)。这些实施方案的另一个方面是排列PEF的方向，以致所述电场沿着靶点细胞的较长的维度和非靶点细胞的较短的维度排列。更具体地，动脉平滑肌细胞是典型的延长细胞，其以通常是螺旋的方向围绕动脉圆周，以致它们的较长维度是圆周性的而不是沿着动脉纵向进行的。另一方面，肾丛的神经通常以动脉的纵向方向沿着动脉外部排列的。因此，预计应用一般沿着动脉的纵向方向排列的PEF优先在靶点神经细胞中引起电穿孔，而没有在相同程度上影响至少一些非靶点动脉平滑肌细胞。这可以使得在血管内装置的血管外膜或动脉周围区域中的神经细胞(靶点细胞)优先去除神经，而没有在不理想的程度上影响血管的平滑肌细胞。
附图简述
当结合附图考虑下述详细描述时，本发明的一些实施方案将是显而易见的，在附图中，相似的参考符号始终是指相似的部件，并且附图中：
图1是图示人肾脏解剖的示意图。
图2是显示肾神经相对于肾动脉的位置的示意性详图。
图3A和3B分别是图示选择性影响肾神经的电流流动方向的示意性侧面图和端面图。
图4是按照本发明的一个实施方案具有多个电极的血管内导管的示意性侧面图，特别是横截面图。
图5是按照本发明另一个实施方案具有一对彼此以理想的距离排列的可扩张的螺旋电极的血管内装置的示意性侧面图，特别是横截面图。
图6是按照本发明的另一个实施方案具有在可扩张的气球上的第一电极和在导管轴上的第二电极的血管内装置的示意性侧面图，特别是横截面图。
图7是按照本发明的另一个实施方案具有沿着导管内腔输送的扩张的第一电极和由所述导管携带的互补性第二电极的血管内装置的示意性侧面图，特别是横截面图。
图8是按照本发明的另一个实施方案具有可扩张的篮和在篮上的多个电极的血管内装置的示意性侧面图，特别是横截面图。
图9是图8的装置的示意性详图，其图示按照本发明的另一个实施方案的一个电极的实施方案。
图10是按照本发明的另一个实施方案具有接触管壁的可扩张的环性电极和任选的绝缘元件的血管内装置的示意性侧面图，特别是横截面图。
图11A-11C是图10的环形电极不同绕组的实施方案的示意性详图。
图12具有图11A-11C所示的绕组的图10环电极的血管内装置的示意性侧面图，特别是横截面图。
图13是按照本发明的另一个实施方案具有环形电极和内腔输送的(luminally-delivered)电极的血管内装置的示意性侧面图，特别是横截面图。
图14是按照本发明的另一个实施方案具有气球导管与接近和远离气球排列的可扩张的点接触电极的血管内装置的示意性侧面图，特别是横截面图。
图15是按照本发明的另一个实施方案具有气球导管与接近和远离气球排列的电极的血管内装置的示意性侧面图。
图16A和16B是图示按照本发明的一个实施方案使用图15的装置的方法阶段的示意性侧面图，特别是横截面图。
图17是按照本发明的另一个实施方案具有气球导管和多个动力学可操纵的电极的血管内装置的示意性侧面图。
图18是按照本发明的另一个实施方案具有沿着气球导管内腔布置的远端电极的血管内装置的示意性侧面图。
图19A和19B是图示使用图18所示的血管内装置调节具有不同的肾血管系统的患者肾神经活性的方法的侧面图，特别是横截面图。
图20是图示按照本发明的另一个实施方案具有多个沿着定中心元件的轴并且与定中心元件直线排列的电极的血管内装置的侧面图，特别是横截面图。
图21是图示按照本发明的另一个实施方案具有设置成动态放射状重新定位以促进脉冲电场的聚焦的电极的血管内装置的侧面图，特别是横截面图。
图22是图示按照本发明的另一个实施方案具有灌注/抽吸导管的血管内装置的侧面图，特别是横截面图。
图23A-23C分别是侧面图特别是横截面图，和沿着横断线图23A的A--A的横截面图，图示使用按照本发明的一个实施方案设置成电极至少部分通过管壁的血管内装置的方法。
图24A和24B是图示按照本发明的另一个实施方案具有检测或监测治疗效果的检测器的血管内装置的侧面图，特别是横截面图。
详述
A.概述
本发明涉及肾神经调节和/或其它神经调节的方法和装置。更具体地，本发明涉及使用脉冲电场完成电穿孔或电融合而进行肾神经调节的方法和装置。当用于本文时，电穿孔和电渗透作用是操作细胞膜或细胞内装置的方法。例如，短的高能脉冲导致细胞膜上的开孔。细胞膜上有孔的程度(例如，孔的大小和数目)和孔的持续时间(例如，暂时的或永久的)是场强、脉冲宽度、工作周期、场方向、细胞类型和其它参数的函数。一般地，当更低强度的场或较短的脉冲宽度终止时，孔通常自动关闭(这里定义为“可逆电穿孔”)。每一细胞类型具有临界阈值，高于所述阈值，孔不会关闭，以致孔的形成不再是可逆的；这一结果定义为“不可逆电穿孔”、“不可逆击穿”或“不可逆损伤”。在这一点上，发生由高有孔性引起的细胞膜破裂和/或不可逆的化学不平衡。这样的高有孔性可能是单个大孔和/或多个更小的孔的结果。也适于用于肾神经调节的某些类型的电穿孔能量参数是具有亚微妙范围持续时间的高电压脉冲(纳秒脉冲电场，或nsPEF)，其可以使得细胞膜完好无损，但是以引起细胞死亡或破裂的方式改变细胞内装置或细胞的功能。已经表明nsPEF的某些应用通过诱导凋亡(apoptosis)或程序性细胞死亡(programmed cell death)而不是急性细胞死亡而引起细胞死亡。并且，术语“包括”贯穿全文用来意指包括至少引用的特征，以便任何更大量的相同特征和/或其它类型特征不被排除在外。
本发明的一些实施方案提供诱导肾神经调节的血管内装置，所述肾神经调节诸如靶点神经中随着时间消散的临时性变化，对神经功能的持续控制，和/或去除神经作用。本文所述的装置和方法可以使用获得理想的神经调节(例如，电穿孔作用)的任何适宜的电信号或场参数，例如，任何电场。为了更好地理解血管内装置的结构和使用这些装置进行神经调节的方法，理解人体肾脏解剖结构是有用的。
B.神经调节方法的选择实施方案
现在参考图1，人肾脏解剖结构包括通过肾动脉RA供应有氧血的肾脏K，肾动脉RA通过腹部大动脉AA与头部相连。去氧血液通过肾静脉RV和下腔静脉IVC从肾脏流到心脏。图2更详细地图示肾脏解剖结构的部分。更具体地，肾脏解剖结构还包括沿着通常在动脉外膜内的肾动脉RA的纵向维度而纵向延伸的肾神经RN。肾动脉RA具有平滑肌细胞SMC，其围绕动脉的角轴θ螺旋而环绕动脉圆周，即，环绕动脉的圆周。因此，肾动脉的平滑肌细胞具有横断肾动脉的纵向维度(即不平行)延伸的纵向或较长维度。肾神经和平滑肌细胞的纵向维度的不重合(misalignment)定义为“细胞不重合”。
参考图3，肾神经和平滑肌细胞的细胞不重合可以用来选择性地影响肾神经细胞，而对平滑肌细胞具有减小的作用。更具体地，由于更大的细胞需要更少的能量超过电穿孔的不可逆阈值，所以，本发明的一些电极的实施方案设置成将由所述电极产生的至少部分电场沿着或者靠近要影响的细胞的较长维度排列。在具体的实施方案中，血管内装置具有这样的电极，即，所述电极被设置成产生沿着或者靠近肾动脉RA的纵向维度排列的电场，以影响肾神经RN。通过排列电场，以便所述场优先影响细胞的纵向方面，而不是细胞的直径或辐射状方面，可以使用更低的场强来使细胞坏死。如上文所提及的那样，预计这可以减少能量消耗，并且减轻对电场中非靶点细胞的作用。
类似地，关于神经细胞的较长维度，在靶点神经之上或之下的组织的纵向或较长的维度是垂直的或另外偏离轴线的(off-axis)(例如，横截的)。因此，除了沿着靶点细胞的纵向或较长维度排列PEF之外，PEF可以沿着非靶点细胞的横向或较短维度传播(即，以致PEF至少部分沿着非靶点平滑肌细胞SMC排列之外传播)。因此，如在图3中所示，使用具有通常沿着肾动脉RA的纵向维度L排列的传播线Li的PEF，预计优先在靶点肾神经RN细胞中引起电穿孔、电融合、去除神经作用或其它神经调节，而不会不适当地影响非靶点动脉平滑肌细胞SMC。脉冲电场可以以沿着肾动脉纵轴的单个平面传播，或者可以以沿着从0°-360°的任何角面(angular segment)θ的纵向方向传播。
图3所示方法的实施方案可以具有关于本发明血管内方法和装置的具体应用。例如，置于肾动脉内的PEF导管可以传播具有纵向部分的电场，所述电场在肾神经RN和管壁的平滑肌细胞SMC区域沿着动脉的纵向维度排列运行，以致动脉壁保持至少基本上是完好的，而外部的神经细胞被破坏。
C.神经调节的系统和其它方法的实施方案
图4显示按照本发明的血管内脉冲电场装置200的一个实施方案，所述装置包括一个或多个电极，所述电极设置成与肾血管系统内的靶点区域物理接触，并且将脉冲电场输送穿过血管系统的壁。装置200显示位于患者肾动脉RA内，但是它可以位于其它血管内位置(例如，肾静脉)。装置200的这一实施方案包括血管内导管210，其具有近端部件211a、远端部件211b、和在远端部件211b的多个远端电极212。近端部件211a通常具有将导管210偶联到脉冲发生器上的接线盒，并且这一实施方案中的远端部件211b具有螺旋构型。装置200电偶联到位于患者近端和外部的脉冲电场发生器100上；电极212通过导管210电偶联到发生器上。发生器100可以用于下文所述的本发明的任何实施方案中，用于输送具有理想场参数的PEF。应该理解，即使所述发生器没有明确地显示或者描述具有任何变化，下文所述的实施方案的电极也可以与发生器连接。
导管210的螺旋远端部件211b被设置成与管壁并列(appose)，并且将电极212引入到血管外神经结构的最近处。螺旋的斜度可以变化，以提供较长的治疗区域，或者将相邻治疗区域的圆周重叠减到最小，以减少形成狭窄的危险。这种斜度变化可以通过将多个不同斜度的导管组合形成导管210而获得，或者通过应用内部牵引线、调节插入到导管内的轴、定型置于导管上的鞘调整导管210的斜度而获得，或者通过任何其它适当的方式在原位或者在引入到机体之前而改变所述斜度。
沿着斜度长度的电极212可以是单个电极，普通但是分节的电极，或者普通而连续的电极。例如，普通连续电极可以包括在导管210的螺旋部分内部形成或者置于其上的传导线圈。例如，普通但是分节的电极可以通过提供适合导管的螺旋部分的有槽管而形成，或者通过电连接一系列的单个电极而形成。
单个电极或电极组212可以设置成提供双极信号，或者所有的电极或电极子集可以与独立的外部患者接地组合在一起用于单极应用(例如，接地盒可以置于患者腿上)。电极212可以动态地分配以促进任何电极之间和/或任何电极和外部接地之间的单极和/或双极能量输送。
导管210可以以在鞘150内部不引人注意的输送构型输送到肾动脉RA。一旦位于动脉内部，导管可以自动膨胀或者主动膨胀，例如，通过牵引线或者气球而膨胀，与动脉内壁接触。然后，脉冲电场可以通过PEF发生器100产生，通过导管210传导到电极212，并且通过电极212输送穿过动脉壁。在许多应用中，电极的排列使得脉冲电场沿着动脉的纵向维度排列，以沿着肾神经调控神经活性(例如，去除神经作用)。例如，这可以通过不可逆的电穿孔、电融合和/或在神经细胞中诱导凋亡而实现。
图5图示按照本发明的另一个实施方案的肾调节装置220。装置220包括一对导管222a和222b，其分别具有可扩张的远端部件223a和223b，223a和223b分别具有螺旋电极224a和224b。在患者肾血管系统内部，螺旋电极224a和224b在空间上彼此距离理想的距离。电极224a-b可以以两极方式作用，以致一个电极是作用电极，另一个电极是回流电极。电极之间的距离可以按照需要改变，以改变场强和/或受电极调控的神经片段的长度。所述可扩张的螺旋电极可以包括形状-记忆特性，所述形状-记忆特性促进自动膨胀，例如在穿过鞘150后自动膨胀，或者所述电极可以主动膨胀以与管壁接触，例如，通过膨胀的气球或通过牵引线等而主动膨胀。导管222a-b优选地在除电极224a-b的远端螺旋以外的区域是电绝缘的。
图6图示装置230，其包括具有可扩张的气球234的气球导管232，围绕气球234排列的螺旋电极236，和在导管232轴上的轴电极238。轴电极238可以如所示那样位于可扩张的气球234的近端，或者轴电极238可以位于可扩张的气球234的远端。
当将装置230输送到靶点血管时，例如位于肾动脉RA内部时，可扩张的气球234和螺旋电极236排列在不引人注意的输送构型内。如图6所示，一旦所述装置已经位于需要的位置，可扩张的气球234可以膨胀，推动螺旋电极236与管壁物理接触。在这一实施方案中，轴电极238不与管壁物理接触。
在常规热RF能量输送和相对非热脉冲RF能量输送领域内，公知能量可以从距离组织本身的短距离传导到要治疗的组织。因此，可以理解“神经接触”包括系统元件与神经的物理接触，以及没有物理接触的单独的电接触，或者两者的组合。任选地可以提供定中心元件，以将电极置于血管的中心区域。例如，所述定中心元件可以包括可扩张的气球诸如装置230的气球234、或下文所述的可扩张的篮。一个或多个电极可以位于定中心元件的中心轴上——与所述元件纵向排列或者位于所述元件的一侧或两侧——如同装置230的轴电极238。当应用气球导管诸如导管232时，膨胀的气球可以作用为增加阻抗的绝缘体，以引导脉冲电场沿着理想的电流路径。显而易见可以应用备选的绝缘体。
如图6所示，当螺旋电极236与肾动脉RA的壁物理接触时，发生器100可以产生PEF，以致电流以两极方式在螺旋电极236和轴电极238之间通过。PEF沿着线Li在电极之间传导，线Li通常沿着动脉纵向维度延伸。气球234在患者血管内局部绝缘和/或增加阻抗，以致PEF通过螺旋和轴电极之间的管壁而传导。这聚焦了能量，增强去除神经作用和/或患者肾神经的其它神经调节作用，例如，通过不可逆的电穿孔进行。
图7图示按照本发明的另一个实施方案与图4-6所示的那些装置相似的装置240。装置240包括具有可扩张的气球244的气球导管242和位于可扩张的气球244近端的轴电极246。装置240还包括可扩张的螺旋电极248，其设置成用于通过导管242的导线内腔243进行输送。图7所示的螺旋电极248是自动扩张的。
如图7所示，在将导管242置于靶点血管(例如，肾动脉RA)后，气球244膨胀直到它接触到管壁，以将轴电极246容纳在血管内的理想位置，并且绝缘或者增加血管内部的阻抗。气球244通常设置成还将轴电极246位于血管内的中心，或者另外间隔轴电极距离管壁理想的距离。在气球244膨胀后，螺旋电极248沿着内腔243推进，直到螺旋电极248超过导管轴；然后电极248扩张或者另外移动成螺旋构型以便与管壁物理接触。然后，两极脉冲电场可以沿着线Li在螺旋电极148和轴电极246之间输送。例如，螺旋电极248可以包括作用电极，并且轴电极246可以包括回流电极，反之亦然。
现在参考图8，描述了包括可扩张的篮的装置，所述篮具有多个电极，其可以扩张与管壁接触。装置250包括导管252，其具有可扩张的篮254，篮254由多个圆周支柱或成员形成。多个电极256沿着篮254的成员形成。篮的每一成员示例性地包括两极电极对，所述两极电极对设置成与肾动脉RA壁或者另一理想的血管壁接触。
例如，篮254可以由多个形状-记忆线或带构成，诸如镍钛诺(Nitinol)、弹簧钢或埃尔吉洛伊非磁性合金线或带，它们形成篮成员253。当篮成员包括带时，带可以移动，以便增加接触管壁的表面区域。篮成员253分别在近端和远端连接255a和255b与导管252偶联。在这样的构型中，篮可以折叠(collapsed)以在鞘150内输送，并且一旦从鞘内移出，就可以自动膨胀与动脉壁接触。近端和/或远端连接255任选地可以设置成沿着导管252的轴调动具体的或不具体的距离，以促进篮的膨胀和折叠。
篮254备选地可以由开槽的和/或激光切割的hypotube形成。在这样的构型中，例如，导管252可以包括相对于彼此可以移动的内轴和外轴。篮254的远端连接255b可以偶联到内轴上，并且篮的近端连接255a可以偶联到外轴上。篮254可以通过使得导管252的内轴和外轴接近，从而使得篮的极端和远端连接255接近并且扩张所述篮，而从折叠的输送构型扩张成为图8的展开构型。同样地，所述篮可以通过分离导管的内轴和外轴而折叠。
如图9所示，单个电极可以验证篮支柱或成员253排列。在一个实施方案中，所述支柱由用绝缘材料包被的传导材料形成，并且电极256可以通过去除绝缘涂层区域而形成。绝缘任选地可以只沿着成员的放射状外表面去除，以便电极256在它们的放射状内表面保持绝缘；预计这将把外部电流导入管壁内。
另外，或者作为图9的制造技术的备选方案，电极可以固定在篮254的支柱或成员的内部表面、外部表面或者包埋在其中。沿着每一支柱或成员放置的电极可以包括单个电极、普通但是分节的电极、或者普通而连续的电极。单个电极或电极组可以与外部患者接地组合在一起作用，用于单极用途。
如图8的实施方案所示使得电极256与管壁接触的一个优点是它可能减少获得肾去除神经作用或其它的神经调节而对绝缘元件诸如可扩张的气球的需求。然而，应该理解，例如，这样的绝缘元件可以在篮内提供并且扩张。此外，使得电极接触壁可以提供提高的场几何学，即，可以提供更加验证血管纵轴排列的电场。这样的接触电极还可以在治疗之前促使神经调节之前、之中或之后的肾神经刺激到达导管252的更好位置，或者监测治疗的功效。
在装置250的一种变体中，电极256可以沿着导管252的中心轴排列，并且篮254可以简单地将电极定于管内中心，以促使能量穿过管壁更精确地输送。这种构型可以非常适合精确靶向血管或血管外组织，诸如围绕肾动脉的肾神经。准确衡量篮或其它定中心元件与动脉的尺寸提供位于中心的电极和动脉壁之间的距离，当需要时，其可以用来引导和/或聚焦电场。这种构型可以用于高密度聚焦超声或微波应用，而且当需要时可以适于与任何其它的能量形式一起应用。
现在参考图10，预计形成于肾动脉壁的圆周接触的电极可以提供更完全的肾去除神经作用或肾神经调节作用。在图10中，描述了本发明包括环形电极的一种变体。装置260包括导管262，其具有可扩张的环形电极264a和264b，所述电极设置成于管壁接触。电极可以通过支柱266附着到导管262的轴上，并且导管262可以设置成通过不引人注意的鞘150输送到肾动脉RA。支柱266可以自动扩张或者可以主动地或机械地扩张。导管262包括导线内腔263用于推进导线。导管262还包括任选的膨胀的气球268，其可以作用为增加阻抗的绝缘元件，用于优先引导在电极264之间传导的电流穿过动脉壁。
图11A-11C图示环形电极264的各种绕组实施方案。如所示的那样，例如，环形电极可以绕组在线圈上(图11A)，Z字形(图11B)或曲折构型(图11C)。按照需要，绕组的周期可以是特异的。此外，绕组类型、周期等可以沿着电极圆周而变化。
参考图12，描述了装置260的一种变体，其包括环形电极264’，环形电极264’具有在图11C中所示的一种曲折绕组实施方案中的正弦绕组。支柱266示例性地附着到正弦曲线的顶点。电极264’的绕组可以提供比电极264更大的沿着管壁的接触区域，同时仍然促使装置260的包复物在鞘150内输送和取回。
图13图示装置260的另一种变体，其包括近端环形电极264a，并且还包括通过导管262的导线内腔263输送的远端电极270。远端电极270是非扩张性的，并且通过导管262位于血管中心。远端电极270可以是于脉冲电场发生器相连并且用作电极的标准导线。然而，应该理解，电极270备选地可以设置成扩张与管壁接触，例如，可以包括环形或螺旋形电极。
通过导管262的内腔输送远端电极可以减少装置260的输送轮廓(delivery profile)和/或可以提高装置的挠性。此外，通过导线内腔输送远端电极可以作为安全特征，其确保医药从业者在输送PEF之前移除置于内腔263的任何导线。它还允许定制治疗长度，以及在旁侧分支部门的治疗，如下文所述。
环形电极264和264’任选地可以是沿着它们的放射状内表面而电绝缘，而它们接触管壁的放射性外表面是暴露的。这可以减少血栓形成的危险，并且还可以提高或增强沿着血管纵轴的电场的方向性。这还可以促使减小中断神经纤维所需的场电压。至少部分绝缘所述环形电极所用的材料可以包括，例如，PTFE、ePTFE、FEP、chronoprene、硅氧烷、氨基甲酸乙酯、Pebx等。参考图14，描述了装置260的另一种变体，其中环形电极被位于支架266末端的点电极272取代。点电极可以与支柱266一起折叠用于通过鞘150输送，并且可以与支柱一起自动扩张与管壁接触。在图14中，导管262示例性地包括在气球268的每一侧面的4个点电极272。然而，应该理解，可以围绕导管262的圆周提供任何需要数目的支架和点电极。
在图14中，装置260示例性地包括在气球268每一侧面上的4个支柱266和4个点电极272。通过应用所有位于远端的电极272b作为作用电极，和所有近端电极272a作为回流电极，或者反之亦然，电场传播所沿着的线Li可以沿着血管纵轴排列。线Li与血管的旋转轴交迭的程度可以通过详细说明围绕导管圆周的点电极272的角度定位和密度，以及通过详细说明PEF的参数而具体化。
现在参考图15，描述了血管内PEF导管的另一种变体。装置280包括导管282，其具有任选的膨胀的气球或定中心元件284，沿着导管轴位于气球每侧的轴电极286a和286b，以及任选的沿着导管轴放置的辐射不透过性的标记288，它们与气球一起用直线图示。气球284作为电极286的定中心元件，并且作为引导电场的电绝缘体，如先前所述那样。
由于准确衡量气球284和靶点动脉之间的尺寸设定了位于中心的电极286和动脉壁之间的已知距离，这可以用于当详细描述PEF的参数时，所以，装置280可以部分很好地适用于获得需要的动脉或动脉外组织的精确靶向。备选地，电极286可以附着到气球284上，而不是附着到导管283的中心轴上，以致它们可以接触动脉壁。在这样的变体中，电极可以固定在气球壁的内表面、外表面或包埋在其中。
沿着导管282的长度排列的电极286可以是单个电极、普通但是分节的电极、或普通而连续的电极。此外，电极286可以设置成提供两极信号，或者电极286可以一起或单独地与分离的患者接地组合应用，用作单极用途。
现在参考图16，描述了使用装置280实现肾去除神经作用的方法。如图16A所示，导管282可以放置在肾动脉RA内需要的位置，气球和定中心元件可以膨胀以使得电极286位于中心，并且任选地提供电绝缘性，并且，例如，PEF可以以两极性方式在近端电极和远端电极286之间输送。预计PEF沿着治疗区域1T1将实现肾去除神经作用和/或神经调节作用。如果需要在肾动脉的其它部分调控神经活性，气球284可以至少部分地放气缩小，并且导管可以放置在第二需要的治疗区域T2，如在图16B中所示。医学执业者任选地可以应用辐射透不过的标记288的荧光成像以将导管282导向治疗的理想位置。例如，医学执业者可以使用所述标记以确定治疗区域T1和T2之间的重叠区域O，如图示。
参考图17，描述了装置280的一种变体，气包括多个位于气球284的近端的动态可控的电极286。在一种变体中，任何一个近端电极286a可以以两极方式与远端电极286b通电，以提供作用电极和回流电极之间纵向距离的动态控制。这改变了治疗区域的大小和形状。在另一种变体中，近端电极286a的任何子集可以一起通电作为在近端电极和远端电极286b之间建立的两极电场的作用电极或回流电极。
尽管图17所示的装置280有3个近端电极286a，但是应该理解，装置280可以具有任何备选数目的近端电极。此外，除了多个近端电极，或者作为备选方案，装置280可以具有多个远端电极286b。另外，一对电极中的一个可以偶联到导管282上，并且另一个电极可以通过导管的内腔输送，例如通过导线内腔输送。导管和内腔-输送的电极可以重新相对于彼此定位，以改变电极之间的分离距离。这样的变体还可以辅助各种肾血管系统异常症的治疗。
在到目前所述的装置280的变体中，远端电极偶联到气球284远端的导管282的轴上。远端电极可以应用导管282内的内腔，例如，用于发送作为接地的导线。另外，气球284远端的导管282部分足够长，足以容纳远端电极。
导管通常在金属的和/或传导的导线上输送。在许多包括导管的干涉治疗中，在治疗过程中并不将导线去除。由于装置280设置成输送脉冲电场，如果不将导线去除，那么对于在能量输送过程中接触导线的任何人可能存在电击的危险。这种危险可以通过应用聚合物-包被的导线而减小。
参考图18，描述装置280的另一种变体，其中图16和17的远端电极286b已经被远端电极270取代，远端电极270设置成沿着导管内腔移动，如先前在图13中所述那样。显而易见地，近端电极286a备选地可以由内腔-输送的电极取代，以便电极286b和270形成两极电极对。电极270不利用导管282内的其它内腔，这可能减少轮廓(profile)。另外，气球远端导管的长度不必占用远端电极的长度，这可以增加挠性。此外，导线必须在治疗之前调换电极270，这减少无意被电击的危险。在一种变体中，电极270任选地可以用作导线，在电极270之上导管282在输送PEF之前被推进到位，因而避免了调换导线和电极的许愿好。备选地，标准金属导线可以简单地通过将所述标准导线与脉冲电场发生器连接而用作电极270。远端电极270可以延长到超出导管282远端末端的任何理想的距离。这可以提供治疗区域长度的动态变化。此外，这可能有助于在减小的直径的远端血管系统内的治疗。
参考图19，可以理想地在从主血管延伸出来的一个或多个血管分支内进行治疗，例如，在邻近肾门的肾动脉的分支内进行治疗。此外，可以理想地在肾血管系统的异常的或少见的分支内进行治疗，这在少数患者中观察到。如图19A所示，远端电极270可以置于肾动脉RA的这样的分支内，而导管282位于所述动脉的主分支内，如图19B所示，可以提供多个远端电极270，并且置于肾动脉的许多常见的或罕见的分支内，而导管保持在主动脉分支内。
参考图20，描述了血管内PEF的另一种变体。装置290包括包括导管292，导管292具有多个与定中性元件296直线放置的轴电极294。定中心元件296示例性地包括可扩张的篮，诸如先前在图8中所述的可扩张的篮254。然而，应该理解定中心元件备选地可以包括气球或任何其它定中心元件。电极294可以以两极或单极形式应用。
现在参考图21，描述了本发明的另一种变体，其包括设置成将一个或多个电极相对于血管壁动态辐射状放置的电极，因而促进由所述电极输送的脉冲电场的聚焦。装置300包括导管302，导管302具有与嵌套的可扩张元件直线放置的电极304。所述嵌套的可扩张元件包括内部可扩张元件306和外部可扩张元件308。电极304沿着内部可扩张元件排列，而外部可扩张的定中心元件设置成使导管302位于血管中心并且稳定之。内部元件306可以膨胀以改变度数，如由医学执业者所需要的那样，以动态改变电极304的辐射状位置。这种动态辐射状重新定位可以用来聚焦由电极304输送的能量，以便它被输送到靶点组织。
嵌套元件306和308可以包括气球-在-气球中的排列，篮-在-篮中的排列，气球和篮的某种组合，或者其它可扩张的嵌套结构。在图21中，内部可扩张元件306示例性地包括可扩张的篮，而外部可扩张的定中心元件308示例性地包括可扩张的气球。电极302沿着内部气球306的表面排列。
本文所述的本发明的任何变体任选地可以设置成在能量应用之前、之中或之后将试剂灌输到治疗区域，例如，以增强或者改进能量的神经破坏或神经调节作用，以保护或者临时转移非靶点细胞，和/或促进显现。灌输试剂的其它应用是显而易见的。如果需要，细胞对灌输细胞的吸收可以通过在灌输试剂的存在下起始细胞中的可逆电穿孔作用而增强。当应用气球定中心元件时，灌注可能是特别理想的。灌输剂(infusate)可以包括，例如，盐水或者肝素化的盐水、保护剂诸如Poloxamer-188、或抗增殖剂。本发明的变体另外或者备选地可以设置成抽吸式的。例如，灌输端口或出口可以在邻近定中心装置的导管轴上，定中心元件可以是多孔的(例如，“渗漏的”气球)，或者篮支柱可以由空心hypotubes制成，并且是开缝或者穿孔的以允许灌注或抽吸。
参考图22，描述了本发明包括灌输/抽吸PEF导管的变体。装置310包括导管312，导管312分别具有近端和远端膨胀的气球314a和314b。近端轴电极316a位于沿着导管312的轴的气球之间，而远端电极316b位于沿着导管轴的气球的远端。一个和多个灌输或抽吸孔318沿着邻近近端电极316a气球之间的导管312的轴排列。
装置310可以以各种方式应用。在第一种应用方法中，导管312位于靶点血管内部，诸如位于肾动脉RA内，在理想的位置。一个或两个气球充满气，并且保护剂或其它灌输剂通过在接近电极316a的气球之间的孔318灌输。适于起始可逆电穿孔的PEF由电极316输送，以促进血管壁内非靶点细胞对灌输剂的吸收。保护剂的输送可以由第一膨胀的远端气球314b而增强，然后灌输保护剂，其取代血液，然后充入近端气球314a。
剩余的灌输剂任选地可以抽吸出来，以便当起始神经细胞的不可逆电穿孔时，它在后续PEF应用过程中是不可用的。抽吸可以通过在抽吸过程中将一个气球至少部分地放气而实现。备选地，抽吸可以用碰撞的气球这样实现，例如，通过灌输盐水与抽吸组合，以冲洗膨胀的气球之间的血管部分。这样的血液冲洗可以减少在PEF应用过程中沿着近端电极316a形成凝块的危险。此外，在能量应用过程中的冲洗可以冷却电极和/或动脉壁的细胞。这样的细胞冷却可以包括细胞免受不可逆电穿孔损伤，可能减少对保护剂灌输的需求。
在灌输和任选地抽吸后，适于在靶点神经细胞中起始不可逆电穿孔作用的PEF可以沿着电极316输送，以去除神经或者调控神经活性。在备选方法中，保护剂的灌输可以在起始电穿孔作用过程中或之后进行，以保护非靶点细胞。例如，保护剂可以堵塞或者充满非靶点细胞中通过不可逆电穿孔作用形成的孔。
在另一种备选方法中，冷却的(例如，低于体温)肝素化的盐水溶液可以同时在膨胀的气球之间灌输和抽吸，以冲洗气球之间的区域，并且减少血管壁细胞对电穿孔作用的敏感性。预计这在应用适于起始不可逆电穿孔作用的PEF过程中进一步保护细胞。这样的冲洗任选地可以在脉冲电场的整个应用过程中持续进行。热电偶或其它温度传感器任选地可以位于气球之间，以便可以调节冷却的灌输剂灌输的速率，以保持需要的温度。冷却的灌输剂优选地不冷却靶点组织，例如，肾神经。保护剂，诸如Poloxamer-188，任选地可以在治疗后作为附加的安全检测而灌注。
灌输备选地可以通过渗漏的气球导管而实现。此外，可以应用具有至少一个电极的冷气球导管(cryoballoon catheter)。冷气球可以在血管部分内部膨胀，以局部减少血管部分的温度，例如，以在输送电场过程中，保护所述部分和/或诱导血管壁的热程序性细胞死亡。例如，电场可以包括PEF或热、非脉冲电场，诸如热RF电场。
现在参考图23，描述了设置成通过至少部分穿过血管壁的电极的PEF导管的变体。例如，所述电极可以位于肾静脉内，然后通过肾静脉壁，以便它们位于Gerota’s或肾筋膜，并且在肾动脉附近或者至少部分围绕肾动脉。在这种方式中，电极可以在输送脉冲电场之前被置于靶点肾神经纤维的邻近。
如图23A所示，装置320包括导管322，导管322具有针形端口324和定中心元件326，定中心元件326示例性是一种膨胀的气球。导管322还任选地可以包括辐射透不过的标记328。针形端口324设置成从中穿过针330，而针330设置成穿过电极340。
肾静脉RV与肾动脉RA平行。一种成像形式，诸如血管内超声，可以用来确定肾动脉相对于肾静脉的位置。例如，血管内超声元件任选地可以结合在导管322内。导管322可以应用公知的经皮技术而置于肾静脉RV内部，并且定中心元件326可以膨胀以将导管稳定在静脉内。然后针330可以以某种方式通过导管322并且从针端口324穿出，从而针穿透肾静脉壁，并且进入Gerota’s或肾筋膜F。辐射不透过性标记328可以用荧光镜显现，以在调整针330之前正确地引导针端口324的方向。
电极340通过针330调整，至少部分环绕肾动脉RA，如在图23A和23B中所示。电极的持续推进可以进一步环绕动脉，如在图23C中所示。随着电极调整，刺激和/或PEF电穿孔波形式可以用来去除神经或调控肾神经。针330任选地可以在治疗之前部分或完全地缩回，以便电极340环绕更多的肾动脉部分。另外，为了提供单极PEF，可以提供和/或开动单一电极340。
灌输剂任选地可以从针330灌输到筋膜F，以通过产生电极的放置空间而促进电极340的放置。灌输剂可以包括，例如，流体、加热的或冷却的流体、空气、CO2、盐水、造影剂、凝胶、传导性流体、或任何其它的空间占据性物质——不管是气体、固体或液体。还可以注射肝素化的盐水。盐水或高渗盐水可以增强电极340之间的传导性。另外或者备选地，药物和/或药物输送元件可以通过针灌输或者置于筋膜内。
治疗后，电极340可以在针330内部缩回，并且针330可以在导管内通过针端口324而缩回。针330任选地足够小，足以发生最小的出血，并且相当迅速地获得止血。为了阻滞血流并且促进凝固过程，气球定中心元件326任选地可以在收回针330之后保持膨胀一段时间。备选地，气球导管可以在移除装置320后推进到肾静脉并且膨胀。
参考图24，描述了本发明包括检测或监测治疗效果的检测器或其它元件的变体。除了输送去除神经的或调控的PEFs，本发明的变体可以设置成输送刺激电场。这些刺激场可以用来准确定位治疗装置，和/或监测调控神经活性中的治疗效果。这可以通过监测已知受肾神经刺激影响的生理参数的反应而实现。这样的参数包括，例如，肾素水平、钠水平、肾血流和血压。刺激还可以用来刺激去除神经作用，以监测治疗效果：当将肾神经去除神经后，针对刺激的已知生理反应应该不再应答这样的刺激而发生。
传出神经刺激波形可以，例如，包括大约1-10Hz的频率，而传入神经刺激波形可以，例如，包括高达大约50Hz的频率。波形振幅可以，例如，在大约50V范围，而脉冲持续时间可以，例如，在高达大约20毫秒的范围。当血管内输送神经刺激波形时，如在本发明的一些实施方案中那样，可以调节场参数诸如频率、振幅和脉冲持续时间，以促进波形通过血管壁输送到靶点神经。此外，尽管已经描述了刺激波形的示例性参数，但是应该理解，当需要时可以应用任何备选的参数。
在先前所述的本发明的变体中用来输送PEFs的电极还可以用来将刺激波形输送到肾血管系统。备选地，所述变体可以包括设置用于刺激的独立的电极。作为另一种备选方案，可以提供分离的刺激装置。
应用刺激确定肾神经的一种方法是刺激所述神经，以便如果肾神经没有被去除神经或调控，那么肾血流受到影响——或者将受到影响。刺激作用减少肾血流，并且这一反应可以由去除神经作用而被减弱或消除。因此，在神经调控之前的刺激预计将减少血流，而当使用如神经调整之前相似的刺激参数和位置时，神经调控之后的刺激预计将不会将血液流动减少到相同的程度。这一现象可以用来定量肾神经调节的程度。本发明的变体可以包括监测肾血液流动的元件，或者监测已知受肾刺激影响的的任何其它肾生理参数的元件。
在图24A中，描述了图16的装置280的变体，其包括监测肾血液流动的元件。具有多普勒超声传感器352的导线350沿着导管282的内腔推进，用于监测肾动脉RA内部的血液流动。多普勒超声传感器352设置成检测流经动脉的速率(velocity)。然后，流动速度可以按照下式计算：
Q＝VA    (1)
其中Q等于流动速度(flow rate)，V等于流动速率(flow velocity)，以及A等于横截面面积。肾血流的基线可以通过在输送刺激波形之前来自传感器352的检测而确定，然后刺激可以在电极286之间输送，优选地使得气球284缩小。肾血流从基线的改变，或者其的缺少，可以用传感器352监测，以确定神经调节和/或肾神经去除神经作用的最佳位置。
图24B示例图24A的装置的变体，其中多普勒超声传感器352偶联到导管282的轴上。传感器352示例性地位于气球284的近端，但是应该理解，传感器备选地可以位于气球的远端。
除了通过多普勒超声作为血管内监测肾血液流动的备选方案之外，这样的监测任选地可以从患者外部进行，因而肾血液流动可以从皮肤上可见(例如，使用超声传感器)。在另一变体中，可以使用一种或多种血管内压力换流器，以感应压力的局部变化，这可能是肾血流的指征。作为另一种备选方案，例如，可以通过检测在已知分离距离的点之间传导的血管内温度输入的时间间隔的热稀释(thermodilution)而确定血液速率。
例如，热电偶可以结合在每一电极286内，或者在每一电极286的附近提供，并且冷却的(即，低于体温)的流体或盐水可以在邻近热电偶的地方灌输。在热电偶之间记录的温度下降的时间间隔可以用来定量流动特征。目的流动特征的基线估计值可以在刺激肾神经之前确定，并且可以与在刺激后确定的特征的第二估计值进行比较。
商业可购的装置任选地可以用来监测治疗。这样的装置包括，例如，可从加利福尼亚州Rancho Cordova的VolcanoTM Therapeutics Inc.获得的SmartWireTM、FlotWireTM和WaveWireTM，以及可从瑞典Uppsala的RADIMedical Systems AB获得的Pressure
Figure G05841711220070607D000301
其它的商购装置将是显而易见的。电穿孔的程度另外或备选地可以使用电阻抗体层摄影术(“EIT”)或其它电阻抗检测法诸如电阻抗指数直接监测。
尽管上文描述了本发明的优选的示例性变体，但是对于本领域的技术人员显而易见地可以进行各种改变和改进，而不背离本发明。例如，尽管主要描述了变体与脉冲电场组合使用，但是应该理解，当需要时可以输送任何其它电场。在附上的权利要求中意欲覆盖落入本发明真正的精神和范围内的所有这样的改变和改进。

Claims (40)

1.用于肾神经调节的装置，所述装置包括：
电场发生器；和
导管，其包含至少一个电偶联于所述电场发生器的电极，
其中所述导管被设置成经皮放置在患者中肾血管系统内，
特征在于所述导管还包括可扩张的螺旋部件，其被设置成定位所述导管以与肾血管系统的血管壁内表面接触，
其中所述至少一个电极位于所述可扩张的螺旋部件，并且其中所述可扩张的螺旋部件被设置以最小化邻近治疗区域的圆周重叠。
2.权利要求1的装置，其中所述至少一个电极被被设置以将电场输送到肾神经，同时所述设备至少部分位于所述肾血管系统内。
3.权利要求1的装置，其中所述至少一个电极被设置以将电场输送到肾神经，同时所述设备至少部分位于所述肾血管系统内，以减少神经信号传导。
4.权利要求1的装置，其中所述的电场发生器包括脉冲电场发生器，其被设置以产生在肾神经中诱导不可逆电穿孔作用的脉冲电场。
5.权利要求3的装置，其中所述导管设置成以减少的输送构型排列，用于在肾血管系统内移动。
6.权利要求3的装置，其中所述电极设置成与肾血管系统的壁物理接触。
7.权利要求6的装置，其中所述至少一个电极选自由可扩张的螺旋电极、可扩张的环形电极、可扩张的点接触电极以及它们的组合组成的组。
8.权利要求3的装置，其中所述导管还包括可扩张的定中心元件，其设置成与肾血管系统的壁物理接触。
9.权利要求8的装置，其中所述可扩张的定中心元件包括可膨胀的气球。。
10.权利要求8的装置，其中所述至少一个电极位于可扩张的定中心元件上，并且设置成与肾血管系统的壁物理接触。
11.权利要求8的装置，其中所述导管还包括轴，并且所述电极的位置沿着所述设备的轴。
12.权利要求11的装置，其中所述导管还包括与定中心元件纵向排列的轴，并且所述电极位于轴上。
13.权利要求8的装置，其中所述至少一个电极包括位于所述定中心元件近端的第一电极，和位于所述定中心元件远端的第二电极，并且其中所述第一和第二电极是两极电极对。
14.权利要求8的装置，其中所述定中心元件被设置以将肾血管系统的部分电绝缘，并且将电场导向肾神经。
15.权利要求3的装置，其中所述导管包含导线内腔，和其中所述至少一个电极是第一电极，和设置成沿着导管的导线内腔移动的第二电极。
16.权利要求15的装置，其中所述第二电极与所述电场发生器电偶联，并且被设置成以两极方式与所述第一电极一起应用。
17.权利要求1的装置，其中所述至少一个电极包括第一电极，并且所述导管还包括第二电极以确定两极电极对。
18.权利要求1的装置，其中所述至少一个电极包括第一动态可控的电极，并且所述导管还包括与电场发生器电偶联的多个其它动态可控的电极。
19.权利要求1的装置，其中所述至少一个电极和电场发生器还设置成输送刺激电场。
20.权利要求1的装置，其中所述导管设置成相对于肾血管系统的壁辐射状地控制性地移动所述电极。
21.权利要求1的装置，其中所述电场发生器设置成产生在肾神经中诱导电融合的脉冲电场。
22.权利要求3的装置，其中所述至少一个电极设置成部分或完全地穿过肾血管系统的壁。
23.权利要求22的装置，其中所述至少一个电极设置成至少部分环绕患者的肾动脉，接着穿过肾血管系统的壁。
24.权利要求1的装置，其还包括设置成灌输试剂穿过肾血管系统的壁的灌注元件。
25.权利要求24的装置，其中所述灌输元件包括滴注的气球导管。
26.权利要求1的装置，其中所述至少一个电极包括作用电极和回流电极，它们一起确定两极电极对，其中作用电极和回流电极中的至少一个设置成动态移动，以改变两极电极对的作用电极和回流电极之间的纵向分离距离。
27.权利要求1的装置，其中所述导管设置成灌输式或抽吸式的。
28.权利要求1的装置，其中所述导管包括一种元件，其用于监测至少一种生理参数对肾神经热疗的响应。
29.权利要求28的装置，其中所述元件选自由多普勒超声传感器、热电偶、压力传感器以及它们的组合组成的组。
30.权利要求1的装置，其中所述导管被设置以使电场的纵向部分沿着肾神经和肾血管系统中的至少一种的纵向维度取向。
31.权利要求1的装置，其中所述至少一个电极包括作用电极和接地电极，所述接地电极被设置成与患者外部附着，以便设置作用电极以单极方式将电场输送到肾神经。
32.权利要求15的装置，其中所述第二电极包括导线。
33.权利要求1的装置，其中所述的电场发生器被设置以产生热电场。
34.权利要求33的装置，其中所述的热电场引起至少部分肾去神经。
35.权利要求33的装置，其中所述的热电场引起至少一个肾神经的至少部分脱落。
36.权利要求1的装置，其中设置所述的电场发生器以产生引起至少部分肾去神经的热RF电场。
37.权利要求1的装置，其中设置所述的电场发生器以产生引起至少一个肾神经脱落的电场。
38.权利要求1的装置，其还包含用于命令所述电场发生器将电能输送到所述至少一个电极的控制器，其中用指令对所述的控制器编程以命令所述的电场发生器。
39.权利要求3的装置，其中所述的导管包含近端部分和远端部分，其中所述的电场发生器被电偶联到所述的近端部分并且所述的至少一个电极被偶联到所述的远端部分。
40.权利要求39的装置，其中所述的导管还包含用于监测温度的热电偶。
CN2005800417112A 2004-10-05 2005-10-05 肾神经调节的装置 Active CN101084038B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201010279054.8A CN101972513B (zh) 2004-10-05 2005-10-05 肾神经调节的方法和装置

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US61625404P 2004-10-05 2004-10-05
US60/616,254 2004-10-05
US62479304P 2004-11-02 2004-11-02
US60/624,793 2004-11-02
US11/129,765 2005-05-13
US11/129,765 US7653438B2 (en) 2002-04-08 2005-05-13 Methods and apparatus for renal neuromodulation
PCT/US2005/035757 WO2006041881A2 (en) 2004-10-05 2005-10-05 Methods and apparatus for renal neuromodulation

Related Child Applications (3)

Application Number Title Priority Date Filing Date
CN2010102788980A Division CN101940815A (zh) 2004-10-05 2005-10-05 肾神经调节的方法和装置
CN2010102790641A Division CN101940816B (zh) 2004-10-05 2005-10-05 肾神经调节的方法和装置
CN201010279054.8A Division CN101972513B (zh) 2004-10-05 2005-10-05 肾神经调节的方法和装置

Publications (2)

Publication Number Publication Date
CN101084038A CN101084038A (zh) 2007-12-05
CN101084038B true CN101084038B (zh) 2010-11-17

Family

ID=37889643

Family Applications (4)

Application Number Title Priority Date Filing Date
CN2010102790641A Active CN101940816B (zh) 2004-10-05 2005-10-05 肾神经调节的方法和装置
CN2005800417112A Active CN101084038B (zh) 2004-10-05 2005-10-05 肾神经调节的装置
CN2010102788980A Pending CN101940815A (zh) 2004-10-05 2005-10-05 肾神经调节的方法和装置
CN201010279054.8A Active CN101972513B (zh) 2004-10-05 2005-10-05 肾神经调节的方法和装置

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CN2010102790641A Active CN101940816B (zh) 2004-10-05 2005-10-05 肾神经调节的方法和装置

Family Applications After (2)

Application Number Title Priority Date Filing Date
CN2010102788980A Pending CN101940815A (zh) 2004-10-05 2005-10-05 肾神经调节的方法和装置
CN201010279054.8A Active CN101972513B (zh) 2004-10-05 2005-10-05 肾神经调节的方法和装置

Country Status (11)

Country Link
US (16) US7653438B2 (zh)
EP (18) EP2868344B1 (zh)
JP (7) JP5646135B2 (zh)
CN (4) CN101940816B (zh)
AT (1) ATE494039T1 (zh)
CA (1) CA2583463C (zh)
DE (9) DE202005022058U1 (zh)
ES (10) ES2684499T3 (zh)
MX (1) MX2007004238A (zh)
PL (1) PL2561905T3 (zh)
WO (1) WO2006041881A2 (zh)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103826694A (zh) * 2011-09-30 2014-05-28 柯惠有限合伙公司 能量传递装置以及使用方法
US9808304B2 (en) 2011-10-27 2017-11-07 Medtronic Cryocath Lp Cryogenic balloon device with electroporation treatment region

Families Citing this family (809)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6302875B1 (en) 1996-10-11 2001-10-16 Transvascular, Inc. Catheters and related devices for forming passageways between blood vessels or other anatomical structures
US7892229B2 (en) 2003-01-18 2011-02-22 Tsunami Medtech, Llc Medical instruments and techniques for treating pulmonary disorders
US8016823B2 (en) 2003-01-18 2011-09-13 Tsunami Medtech, Llc Medical instrument and method of use
US6702811B2 (en) 1999-04-05 2004-03-09 Medtronic, Inc. Ablation catheter assembly with radially decreasing helix and method of use
US6300108B1 (en) 1999-07-21 2001-10-09 The Regents Of The University Of California Controlled electroporation and mass transfer across cell membranes
JP2003513691A (ja) 1999-10-25 2003-04-15 シーラス、コーポレイション 血管を封止するための集束超音波の使用
US6626855B1 (en) 1999-11-26 2003-09-30 Therus Corpoation Controlled high efficiency lesion formation using high intensity ultrasound
US8241274B2 (en) 2000-01-19 2012-08-14 Medtronic, Inc. Method for guiding a medical device
US8251986B2 (en) 2000-08-17 2012-08-28 Angiodynamics, Inc. Method of destroying tissue cells by eletroporation
US6892099B2 (en) 2001-02-08 2005-05-10 Minnesota Medical Physics, Llc Apparatus and method for reducing subcutaneous fat deposits, virtual face lift and body sculpturing by electroporation
US6795728B2 (en) 2001-08-17 2004-09-21 Minnesota Medical Physics, Llc Apparatus and method for reducing subcutaneous fat deposits by electroporation
US6697670B2 (en) 2001-08-17 2004-02-24 Minnesota Medical Physics, Llc Apparatus and method for reducing subcutaneous fat deposits by electroporation with improved comfort of patients
US9433457B2 (en) 2000-12-09 2016-09-06 Tsunami Medtech, Llc Medical instruments and techniques for thermally-mediated therapies
US6994706B2 (en) 2001-08-13 2006-02-07 Minnesota Medical Physics, Llc Apparatus and method for treatment of benign prostatic hyperplasia
USRE42016E1 (en) 2001-08-13 2010-12-28 Angiodynamics, Inc. Apparatus and method for the treatment of benign prostatic hyperplasia
US8974446B2 (en) 2001-10-11 2015-03-10 St. Jude Medical, Inc. Ultrasound ablation apparatus with discrete staggered ablation zones
US8444636B2 (en) 2001-12-07 2013-05-21 Tsunami Medtech, Llc Medical instrument and method of use
US8145317B2 (en) 2002-04-08 2012-03-27 Ardian, Inc. Methods for renal neuromodulation
US20070129761A1 (en) 2002-04-08 2007-06-07 Ardian, Inc. Methods for treating heart arrhythmia
US8774922B2 (en) 2002-04-08 2014-07-08 Medtronic Ardian Luxembourg S.A.R.L. Catheter apparatuses having expandable balloons for renal neuromodulation and associated systems and methods
US7620451B2 (en) 2005-12-29 2009-11-17 Ardian, Inc. Methods and apparatus for pulsed electric field neuromodulation via an intra-to-extravascular approach
US8145316B2 (en) 2002-04-08 2012-03-27 Ardian, Inc. Methods and apparatus for renal neuromodulation
US7162303B2 (en) 2002-04-08 2007-01-09 Ardian, Inc. Renal nerve stimulation method and apparatus for treatment of patients
US7653438B2 (en) 2002-04-08 2010-01-26 Ardian, Inc. Methods and apparatus for renal neuromodulation
US20070135875A1 (en) 2002-04-08 2007-06-14 Ardian, Inc. Methods and apparatus for thermally-induced renal neuromodulation
US9308044B2 (en) 2002-04-08 2016-04-12 Medtronic Ardian Luxembourg S.A.R.L. Methods for therapeutic renal neuromodulation
US8150519B2 (en) 2002-04-08 2012-04-03 Ardian, Inc. Methods and apparatus for bilateral renal neuromodulation
US9308043B2 (en) 2002-04-08 2016-04-12 Medtronic Ardian Luxembourg S.A.R.L. Methods for monopolar renal neuromodulation
US7853333B2 (en) * 2002-04-08 2010-12-14 Ardian, Inc. Methods and apparatus for multi-vessel renal neuromodulation
US8131371B2 (en) 2002-04-08 2012-03-06 Ardian, Inc. Methods and apparatus for monopolar renal neuromodulation
US8150520B2 (en) * 2002-04-08 2012-04-03 Ardian, Inc. Methods for catheter-based renal denervation
US8347891B2 (en) * 2002-04-08 2013-01-08 Medtronic Ardian Luxembourg S.A.R.L. Methods and apparatus for performing a non-continuous circumferential treatment of a body lumen
US20080213331A1 (en) 2002-04-08 2008-09-04 Ardian, Inc. Methods and devices for renal nerve blocking
US9636174B2 (en) 2002-04-08 2017-05-02 Medtronic Ardian Luxembourg S.A.R.L. Methods for therapeutic renal neuromodulation
US20140018880A1 (en) 2002-04-08 2014-01-16 Medtronic Ardian Luxembourg S.A.R.L. Methods for monopolar renal neuromodulation
US7617005B2 (en) 2002-04-08 2009-11-10 Ardian, Inc. Methods and apparatus for thermally-induced renal neuromodulation
US20110207758A1 (en) 2003-04-08 2011-08-25 Medtronic Vascular, Inc. Methods for Therapeutic Renal Denervation
US6978174B2 (en) * 2002-04-08 2005-12-20 Ardian, Inc. Methods and devices for renal nerve blocking
US7756583B2 (en) 2002-04-08 2010-07-13 Ardian, Inc. Methods and apparatus for intravascularly-induced neuromodulation
US8774913B2 (en) * 2002-04-08 2014-07-08 Medtronic Ardian Luxembourg S.A.R.L. Methods and apparatus for intravasculary-induced neuromodulation
AU2003299471A1 (en) 2002-05-07 2004-05-13 Kai Kroll Method and device for treating concer with electrical therapy in conjunction with chemotherapeutic agents and radiation therapy
US20040082859A1 (en) 2002-07-01 2004-04-29 Alan Schaer Method and apparatus employing ultrasound energy to treat body sphincters
US20100152607A1 (en) * 2003-02-21 2010-06-17 Kassab Ghassan S Devices, systems, and methods for measuring parallel tissue conductance, luminal cross-sectional areas, fluid velocity, and/or determining plaque vulnerability using temperature
US20040226556A1 (en) 2003-05-13 2004-11-18 Deem Mark E. Apparatus for treating asthma using neurotoxin
US8116883B2 (en) 2003-06-04 2012-02-14 Synecor Llc Intravascular device for neuromodulation
DE202004021944U1 (de) 2003-09-12 2013-07-16 Vessix Vascular, Inc. Auswählbare exzentrische Remodellierung und/oder Ablation von atherosklerotischem Material
US8298222B2 (en) * 2003-12-24 2012-10-30 The Regents Of The University Of California Electroporation to deliver chemotherapeutics and enhance tumor regression
US8048067B2 (en) 2003-12-24 2011-11-01 The Regents Of The University Of California Tissue ablation with irreversible electroporation
US9974607B2 (en) 2006-10-18 2018-05-22 Vessix Vascular, Inc. Inducing desirable temperature effects on body tissue
US8396548B2 (en) * 2008-11-14 2013-03-12 Vessix Vascular, Inc. Selective drug delivery in a lumen
US9713730B2 (en) 2004-09-10 2017-07-25 Boston Scientific Scimed, Inc. Apparatus and method for treatment of in-stent restenosis
US7937143B2 (en) 2004-11-02 2011-05-03 Ardian, Inc. Methods and apparatus for inducing controlled renal neuromodulation
US9510930B2 (en) 2008-10-22 2016-12-06 Contego Medical, Llc Angioplasty device with embolic filter
US9707071B2 (en) 2004-11-24 2017-07-18 Contego Medical Llc Percutaneous transluminal angioplasty device with integral embolic filter
WO2006063199A2 (en) 2004-12-09 2006-06-15 The Foundry, Inc. Aortic valve repair
EP1865870B8 (en) 2005-03-28 2012-04-04 Vessix Vascular, Inc. Intraluminal electrical tissue characterization and tuned rf energy for selective treatment of atheroma and other target tissues
US7499748B2 (en) * 2005-04-11 2009-03-03 Cardiac Pacemakers, Inc. Transvascular neural stimulation device
US8114070B2 (en) 2005-06-24 2012-02-14 Angiodynamics, Inc. Methods and systems for treating BPH using electroporation
US20060293730A1 (en) 2005-06-24 2006-12-28 Boris Rubinsky Methods and systems for treating restenosis sites using electroporation
US20070021803A1 (en) 2005-07-22 2007-01-25 The Foundry Inc. Systems and methods for neuromodulation for treatment of pain and other disorders associated with nerve conduction
US20070032785A1 (en) 2005-08-03 2007-02-08 Jennifer Diederich Tissue evacuation device
US8140170B2 (en) 2005-09-12 2012-03-20 The Cleveland Clinic Foundation Method and apparatus for renal neuromodulation
CN101282677B (zh) * 2005-10-05 2010-07-28 奥林巴斯医疗株式会社 胶囊式医疗装置、其引导系统和引导方法、及被检体内插入装置
US20070233185A1 (en) 2005-10-20 2007-10-04 Thomas Anderson Systems and methods for sealing a vascular opening
US10716749B2 (en) * 2005-11-03 2020-07-21 Palo Alto Investors Methods and compositions for treating a renal disease condition in a subject
US7519253B2 (en) 2005-11-18 2009-04-14 Omni Sciences, Inc. Broadband or mid-infrared fiber light sources
WO2007075593A1 (en) * 2005-12-20 2007-07-05 The Cleveland Clinic Foundation Apparatus and method for modulating the baroreflex system
US7993334B2 (en) * 2005-12-29 2011-08-09 Boston Scientific Scimed, Inc. Low-profile, expanding single needle ablation probe
US20110077628A1 (en) * 2006-01-10 2011-03-31 Tsunami Medtech, Llc Medical system and method of use
CA2643210C (en) * 2006-02-24 2018-05-01 Eastern Virginia Medical School Nanosecond pulsed electric fields cause melanomas to self-destruct
US8571650B2 (en) * 2006-03-03 2013-10-29 Palo Alto Investors Methods and compositions for treating a renal associated condition in a subject
US8401650B2 (en) * 2008-04-10 2013-03-19 Electrocore Llc Methods and apparatus for electrical treatment using balloon and electrode
US8019435B2 (en) 2006-05-02 2011-09-13 Boston Scientific Scimed, Inc. Control of arterial smooth muscle tone
WO2007136566A2 (en) 2006-05-19 2007-11-29 Prorhythm, Inc. Ablation device with optimized input power profile and method of using the same
US20080039746A1 (en) 2006-05-25 2008-02-14 Medtronic, Inc. Methods of using high intensity focused ultrasound to form an ablated tissue area containing a plurality of lesions
US7894906B2 (en) 2006-06-06 2011-02-22 Cardiac Pacemakers, Inc. Amelioration of chronic pain by endolymphatic stimulation
US7734341B2 (en) 2006-06-06 2010-06-08 Cardiac Pacemakers, Inc. Method and apparatus for gastrointestinal stimulation via the lymphatic system
US8126538B2 (en) 2006-06-06 2012-02-28 Cardiac Pacemakers, Inc. Method and apparatus for introducing endolymphatic instrumentation
US20070282376A1 (en) 2006-06-06 2007-12-06 Shuros Allan C Method and apparatus for neural stimulation via the lymphatic system
CN101610735B (zh) * 2006-06-28 2015-07-01 美敦力Af卢森堡公司 用于热诱导的肾神经调制的方法和系统
US8905999B2 (en) 2006-09-01 2014-12-09 Cardiac Pacemakers, Inc. Method and apparatus for endolymphatic drug delivery
JP2010506657A (ja) * 2006-10-16 2010-03-04 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 組織の不可逆的エレクトロポレーションに使用される、所定の導電率を有するゲル
EP2455036B1 (en) 2006-10-18 2015-07-15 Vessix Vascular, Inc. Tuned RF energy and electrical tissue characterization for selective treatment of target tissues
CA2666663C (en) 2006-10-18 2016-02-09 Minnow Medical, Inc. System for inducing desirable temperature effects on body tissue
US20080119907A1 (en) * 2006-11-22 2008-05-22 Cardiac Pacemakers, Inc. Renal function modulation via application of electrical energy stimulation
US20080132885A1 (en) * 2006-12-01 2008-06-05 Boris Rubinsky Methods for treating tissue sites using electroporation
US20080132884A1 (en) * 2006-12-01 2008-06-05 Boris Rubinsky Systems for treating tissue sites using electroporation
US7744618B2 (en) * 2006-12-07 2010-06-29 Cardiac Pacemakers, Inc. Device and method for modulating renal function
CA2877177C (en) 2007-01-29 2018-05-22 Simon Fraser University Transvascular nerve stimulation apparatus and methods
CA2714754A1 (en) 2007-02-13 2008-08-21 Virender K. Sharma Method and apparatus for electrical stimulation of the pancreatico-biliary system
US7655004B2 (en) 2007-02-15 2010-02-02 Ethicon Endo-Surgery, Inc. Electroporation ablation apparatus, system, and method
US7815662B2 (en) 2007-03-08 2010-10-19 Ethicon Endo-Surgery, Inc. Surgical suture anchors and deployment device
US11679261B2 (en) 2007-03-09 2023-06-20 Mainstay Medical Limited Systems and methods for enhancing function of spine stabilization muscles associated with a spine surgery intervention
US11679262B2 (en) 2007-03-09 2023-06-20 Mainstay Medical Limited Systems and methods for restoring muscle function to the lumbar spine
US8496653B2 (en) * 2007-04-23 2013-07-30 Boston Scientific Scimed, Inc. Thrombus removal
US8075572B2 (en) 2007-04-26 2011-12-13 Ethicon Endo-Surgery, Inc. Surgical suturing apparatus
WO2008134651A2 (en) * 2007-04-27 2008-11-06 St. Jude Medical, Atrial Fibrillation Division, Inc. Apparatus and method for positioning and retention of catheter
US8100922B2 (en) 2007-04-27 2012-01-24 Ethicon Endo-Surgery, Inc. Curved needle suturing tool
US8103359B2 (en) * 2007-05-17 2012-01-24 Cardiac Pacemakers, Inc. Systems and methods for fixating transvenously implanted medical devices
WO2008150941A2 (en) 2007-05-30 2008-12-11 The Cleveland Clinic Foundation Method for treating erectile dysfunction
WO2009009398A1 (en) 2007-07-06 2009-01-15 Tsunami Medtech, Llc Medical system and method of use
EP2198797B1 (en) 2007-08-23 2011-04-13 Aegea Medical, Inc. Uterine therapy device
US8568410B2 (en) 2007-08-31 2013-10-29 Ethicon Endo-Surgery, Inc. Electrical ablation surgical instruments
US8579897B2 (en) 2007-11-21 2013-11-12 Ethicon Endo-Surgery, Inc. Bipolar forceps
US8262655B2 (en) 2007-11-21 2012-09-11 Ethicon Endo-Surgery, Inc. Bipolar forceps
WO2009046720A1 (en) * 2007-10-11 2009-04-16 Region Hovedstaden V/Herlev Hospital An electroporation device for improved electrical field control
US20090112059A1 (en) 2007-10-31 2009-04-30 Nobis Rudolph H Apparatus and methods for closing a gastrotomy
US8480657B2 (en) 2007-10-31 2013-07-09 Ethicon Endo-Surgery, Inc. Detachable distal overtube section and methods for forming a sealable opening in the wall of an organ
US8298216B2 (en) 2007-11-14 2012-10-30 Myoscience, Inc. Pain management using cryogenic remodeling
US8989858B2 (en) 2007-12-05 2015-03-24 The Invention Science Fund I, Llc Implant system for chemical modulation of neural activity
US8170659B2 (en) 2007-12-05 2012-05-01 The Invention Science Fund I, Llc Method for thermal modulation of neural activity
US8180446B2 (en) 2007-12-05 2012-05-15 The Invention Science Fund I, Llc Method and system for cyclical neural modulation based on activity state
US8165668B2 (en) 2007-12-05 2012-04-24 The Invention Science Fund I, Llc Method for magnetic modulation of neural conduction
US8195287B2 (en) 2007-12-05 2012-06-05 The Invention Science Fund I, Llc Method for electrical modulation of neural conduction
US8170658B2 (en) 2007-12-05 2012-05-01 The Invention Science Fund I, Llc System for electrical modulation of neural conduction
US8180447B2 (en) 2007-12-05 2012-05-15 The Invention Science Fund I, Llc Method for reversible chemical modulation of neural activity
US8165669B2 (en) 2007-12-05 2012-04-24 The Invention Science Fund I, Llc System for magnetic modulation of neural conduction
US8483831B1 (en) 2008-02-15 2013-07-09 Holaira, Inc. System and method for bronchial dilation
US9924992B2 (en) 2008-02-20 2018-03-27 Tsunami Medtech, Llc Medical system and method of use
US8262680B2 (en) 2008-03-10 2012-09-11 Ethicon Endo-Surgery, Inc. Anastomotic device
WO2009121017A1 (en) 2008-03-27 2009-10-01 The Regents Of The University Of California Balloon catheter for reducing restenosis via irreversible electroporation
US7925352B2 (en) 2008-03-27 2011-04-12 Synecor Llc System and method for transvascularly stimulating contents of the carotid sheath
US9867652B2 (en) 2008-04-29 2018-01-16 Virginia Tech Intellectual Properties, Inc. Irreversible electroporation using tissue vasculature to treat aberrant cell masses or create tissue scaffolds
US10245098B2 (en) 2008-04-29 2019-04-02 Virginia Tech Intellectual Properties, Inc. Acute blood-brain barrier disruption using electrical energy based therapy
US8992517B2 (en) 2008-04-29 2015-03-31 Virginia Tech Intellectual Properties Inc. Irreversible electroporation to treat aberrant cell masses
US11254926B2 (en) 2008-04-29 2022-02-22 Virginia Tech Intellectual Properties, Inc. Devices and methods for high frequency electroporation
US10448989B2 (en) 2009-04-09 2019-10-22 Virginia Tech Intellectual Properties, Inc. High-frequency electroporation for cancer therapy
US10238447B2 (en) 2008-04-29 2019-03-26 Virginia Tech Intellectual Properties, Inc. System and method for ablating a tissue site by electroporation with real-time monitoring of treatment progress
US10117707B2 (en) 2008-04-29 2018-11-06 Virginia Tech Intellectual Properties, Inc. System and method for estimating tissue heating of a target ablation zone for electrical-energy based therapies
US11272979B2 (en) 2008-04-29 2022-03-15 Virginia Tech Intellectual Properties, Inc. System and method for estimating tissue heating of a target ablation zone for electrical-energy based therapies
US8926606B2 (en) 2009-04-09 2015-01-06 Virginia Tech Intellectual Properties, Inc. Integration of very short electric pulses for minimally to noninvasive electroporation
WO2009134876A1 (en) 2008-04-29 2009-11-05 Virginia Tech Intellectual Properties, Inc. Irreversible electroporation to create tissue scaffolds
US9198733B2 (en) 2008-04-29 2015-12-01 Virginia Tech Intellectual Properties, Inc. Treatment planning for electroporation-based therapies
US10272178B2 (en) 2008-04-29 2019-04-30 Virginia Tech Intellectual Properties Inc. Methods for blood-brain barrier disruption using electrical energy
US9283051B2 (en) 2008-04-29 2016-03-15 Virginia Tech Intellectual Properties, Inc. System and method for estimating a treatment volume for administering electrical-energy based therapies
US10702326B2 (en) * 2011-07-15 2020-07-07 Virginia Tech Intellectual Properties, Inc. Device and method for electroporation based treatment of stenosis of a tubular body part
US20090281477A1 (en) 2008-05-09 2009-11-12 Angiodynamics, Inc. Electroporation device and method
JP2011519699A (ja) 2008-05-09 2011-07-14 インノブアトイブエ プルモナルイ ソルウトイオンス，インコーポレイティッド 気管支樹の治療のためのシステム、アセンブリ、及び方法
US8317806B2 (en) 2008-05-30 2012-11-27 Ethicon Endo-Surgery, Inc. Endoscopic suturing tension controlling and indication devices
US8070759B2 (en) 2008-05-30 2011-12-06 Ethicon Endo-Surgery, Inc. Surgical fastening device
US8771260B2 (en) 2008-05-30 2014-07-08 Ethicon Endo-Surgery, Inc. Actuating and articulating surgical device
US8652150B2 (en) 2008-05-30 2014-02-18 Ethicon Endo-Surgery, Inc. Multifunction surgical device
US8114072B2 (en) 2008-05-30 2012-02-14 Ethicon Endo-Surgery, Inc. Electrical ablation device
US8679003B2 (en) 2008-05-30 2014-03-25 Ethicon Endo-Surgery, Inc. Surgical device and endoscope including same
US8721632B2 (en) 2008-09-09 2014-05-13 Tsunami Medtech, Llc Methods for delivering energy into a target tissue of a body
US8906035B2 (en) 2008-06-04 2014-12-09 Ethicon Endo-Surgery, Inc. Endoscopic drop off bag
US8403926B2 (en) 2008-06-05 2013-03-26 Ethicon Endo-Surgery, Inc. Manually articulating devices
US8713026B2 (en) * 2008-06-13 2014-04-29 Sandisk Technologies Inc. Method for playing digital media files with a digital media player using a plurality of playlists
US9173704B2 (en) 2008-06-20 2015-11-03 Angiodynamics, Inc. Device and method for the ablation of fibrin sheath formation on a venous catheter
WO2010008834A2 (en) 2008-06-23 2010-01-21 Angiodynamics, Inc. Treatment devices and methods
US8361112B2 (en) 2008-06-27 2013-01-29 Ethicon Endo-Surgery, Inc. Surgical suture arrangement
EP2318093B1 (en) * 2008-07-02 2019-11-13 Sage Products, LLC Systems for automated muscle stimulation
US8892210B2 (en) 2008-07-02 2014-11-18 Niveus Medical, Inc. Devices, systems, and methods for automated optimization of energy delivery
US8888792B2 (en) 2008-07-14 2014-11-18 Ethicon Endo-Surgery, Inc. Tissue apposition clip application devices and methods
US8262563B2 (en) 2008-07-14 2012-09-11 Ethicon Endo-Surgery, Inc. Endoscopic translumenal articulatable steerable overtube
US8768469B2 (en) 2008-08-08 2014-07-01 Enteromedics Inc. Systems for regulation of blood pressure and heart rate
WO2010019481A1 (en) 2008-08-11 2010-02-18 Conceptx Medical, Inc. Systems and methods for treating dyspnea, including via electrical afferent signal blocking
US8211125B2 (en) 2008-08-15 2012-07-03 Ethicon Endo-Surgery, Inc. Sterile appliance delivery device for endoscopic procedures
US9149386B2 (en) 2008-08-19 2015-10-06 Niveus Medical, Inc. Devices and systems for stimulation of tissues
ES2908706T3 (es) * 2008-08-20 2022-05-03 Prostacare Pty Ltd Sistema que incluye un catéter y electrodos desplegables para la ablación no térmica de tejidos
US10736689B2 (en) 2008-08-20 2020-08-11 Prostacare Pty Ltd Low-corrosion electrode for treating tissue
US8529563B2 (en) 2008-08-25 2013-09-10 Ethicon Endo-Surgery, Inc. Electrical ablation devices
WO2010027874A2 (en) * 2008-08-26 2010-03-11 Niveus Medical, Inc. Device, system, and method to improve powered muscle stimulation performance in the presence of tissue edema
US8241204B2 (en) 2008-08-29 2012-08-14 Ethicon Endo-Surgery, Inc. Articulating end cap
US8480689B2 (en) 2008-09-02 2013-07-09 Ethicon Endo-Surgery, Inc. Suturing device
US8409200B2 (en) 2008-09-03 2013-04-02 Ethicon Endo-Surgery, Inc. Surgical grasping device
US8114119B2 (en) 2008-09-09 2012-02-14 Ethicon Endo-Surgery, Inc. Surgical grasping device
AU2009292987A1 (en) * 2008-09-22 2010-03-25 Vessix Vascular, Inc Inducing desirable temperature effects on body tissue using alternate energy sources
AU2009292925A1 (en) 2008-09-22 2010-03-25 Dtherapeutics, Llc Devices, systems, and methods for determining fractional flow reserve
US8337394B2 (en) 2008-10-01 2012-12-25 Ethicon Endo-Surgery, Inc. Overtube with expandable tip
US10695126B2 (en) 2008-10-06 2020-06-30 Santa Anna Tech Llc Catheter with a double balloon structure to generate and apply a heated ablative zone to tissue
US9561068B2 (en) 2008-10-06 2017-02-07 Virender K. Sharma Method and apparatus for tissue ablation
US10064697B2 (en) 2008-10-06 2018-09-04 Santa Anna Tech Llc Vapor based ablation system for treating various indications
US9561066B2 (en) 2008-10-06 2017-02-07 Virender K. Sharma Method and apparatus for tissue ablation
EP2341859B1 (en) 2008-10-06 2017-04-05 Virender K. Sharma Apparatus for tissue ablation
US10603489B2 (en) 2008-10-09 2020-03-31 Virender K. Sharma Methods and apparatuses for stimulating blood vessels in order to control, treat, and/or prevent a hemorrhage
US9079028B2 (en) 2008-10-09 2015-07-14 Virender K. Sharma Method and apparatus for stimulating the vascular system
US20100114244A1 (en) * 2008-10-31 2010-05-06 Medtronic, Inc. Electrical renal autonomic blockade
US8386053B2 (en) * 2008-10-31 2013-02-26 Medtronic, Inc. Subclavian ansae stimulation
US7910193B2 (en) * 2008-11-10 2011-03-22 Mkp Structural Design Associates, Inc. Three-dimensional auxetic structures and applications thereof
US10987494B2 (en) 2008-11-11 2021-04-27 Covidien Lp Pleated or folded catheter-mounted balloon
US9795442B2 (en) 2008-11-11 2017-10-24 Shifamed Holdings, Llc Ablation catheters
US11376061B2 (en) 2008-11-11 2022-07-05 Covidien Lp Energy delivery device and methods of use
WO2010056771A1 (en) * 2008-11-11 2010-05-20 Shifamed Llc Low profile electrode assembly
WO2010056745A1 (en) 2008-11-17 2010-05-20 Minnow Medical, Inc. Selective accumulation of energy with or without knowledge of tissue topography
US8382746B2 (en) 2008-11-21 2013-02-26 C2 Therapeutics, Inc. Cryogenic ablation system and method
US8157834B2 (en) 2008-11-25 2012-04-17 Ethicon Endo-Surgery, Inc. Rotational coupling device for surgical instrument with flexible actuators
US8923970B2 (en) 2008-12-09 2014-12-30 Nephera Ltd. Stimulation of the urinary system
US8725249B2 (en) 2008-12-09 2014-05-13 Nephera Ltd. Stimulation of the urinary system
US8172772B2 (en) 2008-12-11 2012-05-08 Ethicon Endo-Surgery, Inc. Specimen retrieval device
US20100152725A1 (en) * 2008-12-12 2010-06-17 Angiodynamics, Inc. Method and system for tissue treatment utilizing irreversible electroporation and thermal track coagulation
US8652129B2 (en) 2008-12-31 2014-02-18 Medtronic Ardian Luxembourg S.A.R.L. Apparatus, systems, and methods for achieving intravascular, thermally-induced renal neuromodulation
US20100168739A1 (en) * 2008-12-31 2010-07-01 Ardian, Inc. Apparatus, systems, and methods for achieving intravascular, thermally-induced renal neuromodulation
US8808345B2 (en) * 2008-12-31 2014-08-19 Medtronic Ardian Luxembourg S.A.R.L. Handle assemblies for intravascular treatment devices and associated systems and methods
US8974445B2 (en) * 2009-01-09 2015-03-10 Recor Medical, Inc. Methods and apparatus for treatment of cardiac valve insufficiency
US8361066B2 (en) 2009-01-12 2013-01-29 Ethicon Endo-Surgery, Inc. Electrical ablation devices
US8828031B2 (en) 2009-01-12 2014-09-09 Ethicon Endo-Surgery, Inc. Apparatus for forming an anastomosis
WO2010083086A1 (en) * 2009-01-14 2010-07-22 Cardiac Pacemakers, Inc. Promoting diuresis and natriuresis by applying electric field
WO2010085765A2 (en) 2009-01-23 2010-07-29 Moshe Meir H Therapeutic energy delivery device with rotational mechanism
US8252057B2 (en) 2009-01-30 2012-08-28 Ethicon Endo-Surgery, Inc. Surgical access device
US9226772B2 (en) 2009-01-30 2016-01-05 Ethicon Endo-Surgery, Inc. Surgical device
US8037591B2 (en) 2009-02-02 2011-10-18 Ethicon Endo-Surgery, Inc. Surgical scissors
US11284931B2 (en) 2009-02-03 2022-03-29 Tsunami Medtech, Llc Medical systems and methods for ablating and absorbing tissue
US8231603B2 (en) 2009-02-10 2012-07-31 Angiodynamics, Inc. Irreversible electroporation and tissue regeneration
CA2751527C (en) 2009-02-20 2020-05-05 Niveus Medical, Inc. Systems and methods of powered muscle stimulation using an energy guidance field
US11638603B2 (en) 2009-04-09 2023-05-02 Virginia Tech Intellectual Properties, Inc. Selective modulation of intracellular effects of cells using pulsed electric fields
US11382681B2 (en) 2009-04-09 2022-07-12 Virginia Tech Intellectual Properties, Inc. Device and methods for delivery of high frequency electrical pulses for non-thermal ablation
USD630321S1 (en) 2009-05-08 2011-01-04 Angio Dynamics, Inc. Probe handle
US8551096B2 (en) 2009-05-13 2013-10-08 Boston Scientific Scimed, Inc. Directional delivery of energy and bioactives
US8903488B2 (en) 2009-05-28 2014-12-02 Angiodynamics, Inc. System and method for synchronizing energy delivery to the cardiac rhythm
US9895189B2 (en) 2009-06-19 2018-02-20 Angiodynamics, Inc. Methods of sterilization and treating infection using irreversible electroporation
EP2445568B1 (en) * 2009-06-24 2020-09-23 Kalila Medical, Inc. Steerable medical delivery devices
WO2011008903A2 (en) * 2009-07-15 2011-01-20 Uab Research Foundation Catheter having temperature controlled anchor and related methods
US8517962B2 (en) 2009-10-12 2013-08-27 Kona Medical, Inc. Energetic modulation of nerves
US9119951B2 (en) 2009-10-12 2015-09-01 Kona Medical, Inc. Energetic modulation of nerves
US20110118600A1 (en) 2009-11-16 2011-05-19 Michael Gertner External Autonomic Modulation
US8469904B2 (en) 2009-10-12 2013-06-25 Kona Medical, Inc. Energetic modulation of nerves
US8986231B2 (en) 2009-10-12 2015-03-24 Kona Medical, Inc. Energetic modulation of nerves
US20160059044A1 (en) * 2009-10-12 2016-03-03 Kona Medical, Inc. Energy delivery to intraparenchymal regions of the kidney to treat hypertension
US9174065B2 (en) 2009-10-12 2015-11-03 Kona Medical, Inc. Energetic modulation of nerves
US8295912B2 (en) * 2009-10-12 2012-10-23 Kona Medical, Inc. Method and system to inhibit a function of a nerve traveling with an artery
BR112012008538A2 (pt) * 2009-10-12 2016-04-05 Kona Medical Inc modulação energética de nervos
US20110092880A1 (en) 2009-10-12 2011-04-21 Michael Gertner Energetic modulation of nerves
US8986211B2 (en) 2009-10-12 2015-03-24 Kona Medical, Inc. Energetic modulation of nerves
EP2490756A1 (en) * 2009-10-19 2012-08-29 Cardiac Pacemakers, Inc. Cardiorenal electrical stimulation system
KR101722290B1 (ko) 2009-10-27 2017-03-31 호라이라 인코포레이티드 냉각 가능한 에너지 에미팅 어셈블리를 갖는 전달 장치
US20110098704A1 (en) 2009-10-28 2011-04-28 Ethicon Endo-Surgery, Inc. Electrical ablation devices
CA2779455A1 (en) * 2009-10-30 2011-05-05 Sound Interventions, Inc. Method and apparatus for non-invasive treatment of hypertension through ultrasound renal denervation
CA2779386C (en) 2009-10-30 2018-09-11 Sound Interventions, Inc. Method and apparatus for treatment of hypertension through percutaneous ultrasound renal denervation
US8608652B2 (en) 2009-11-05 2013-12-17 Ethicon Endo-Surgery, Inc. Vaginal entry surgical devices, kit, system, and method
US20110112527A1 (en) * 2009-11-06 2011-05-12 Angiodynamics, Inc. Flexible medical ablation device and method of use
US20110112400A1 (en) * 2009-11-06 2011-05-12 Ardian, Inc. High intensity focused ultrasound catheter apparatuses, systems, and methods for renal neuromodulation
US8900223B2 (en) * 2009-11-06 2014-12-02 Tsunami Medtech, Llc Tissue ablation systems and methods of use
WO2011060056A2 (en) 2009-11-11 2011-05-19 Niveus Mediacl, Inc. Synergistic muscle activation device
CN102711645B (zh) 2009-11-11 2016-12-28 赫莱拉公司 用于处理组织和控制狭窄的系统和装置
US8911439B2 (en) 2009-11-11 2014-12-16 Holaira, Inc. Non-invasive and minimally invasive denervation methods and systems for performing the same
BR112012011042A2 (pt) 2009-11-13 2019-09-24 St Jude Medical cateter de ablação.
US20110118732A1 (en) 2009-11-19 2011-05-19 The Regents Of The University Of California Controlled irreversible electroporation
US8696698B2 (en) 2009-12-02 2014-04-15 Surefire Medical, Inc. Microvalve protection device and method of use for protection against embolization agent reflux
US9539081B2 (en) 2009-12-02 2017-01-10 Surefire Medical, Inc. Method of operating a microvalve protection device
EP2512330A1 (en) 2009-12-14 2012-10-24 Mayo Foundation for Medical Education and Research Device and method for treating cardiac disorders by modulating autonomic response
US8353487B2 (en) 2009-12-17 2013-01-15 Ethicon Endo-Surgery, Inc. User interface support devices for endoscopic surgical instruments
US8496574B2 (en) 2009-12-17 2013-07-30 Ethicon Endo-Surgery, Inc. Selectively positionable camera for surgical guide tube assembly
US8506564B2 (en) 2009-12-18 2013-08-13 Ethicon Endo-Surgery, Inc. Surgical instrument comprising an electrode
US9028483B2 (en) * 2009-12-18 2015-05-12 Ethicon Endo-Surgery, Inc. Surgical instrument comprising an electrode
US9162075B2 (en) 2009-12-23 2015-10-20 Hitops Gmbh Use of pulsed radio frequency
US9161801B2 (en) * 2009-12-30 2015-10-20 Tsunami Medtech, Llc Medical system and method of use
US20110263921A1 (en) * 2009-12-31 2011-10-27 Anthony Vrba Patterned Denervation Therapy for Innervated Renal Vasculature
CA2786262A1 (en) 2010-01-07 2011-07-14 Cheetah Omni, Llc Fiber lasers and mid-infrared light sources in methods and systems for selective biological tissue processing and spectroscopy
US9072894B2 (en) * 2010-01-18 2015-07-07 The Board Of Trustees Of The Leland Stanford Junior University Method and apparatus for radioablation of regular targets such as sympathetic nerves
WO2011091069A1 (en) * 2010-01-19 2011-07-28 Ardian, Inc. Methods and apparatus for renal neuromodulation via stereotactic radiotherapy
EP2528649A1 (en) * 2010-01-26 2012-12-05 Michael A. Evans Methods, devices, and agents for denervation
US20110190858A1 (en) * 2010-01-29 2011-08-04 Medtronic, Inc. Lead having expandable distal portion
US9005198B2 (en) 2010-01-29 2015-04-14 Ethicon Endo-Surgery, Inc. Surgical instrument comprising an electrode
US20110202052A1 (en) * 2010-02-12 2011-08-18 Daniel Gelbart System for treating benign prostatic hyperplasia
US20110208175A1 (en) * 2010-02-24 2011-08-25 Medtronic Vascular, Inc. Methods for Treating Sleep Apnea Via Renal Denervation
US8556891B2 (en) 2010-03-03 2013-10-15 Medtronic Ablation Frontiers Llc Variable-output radiofrequency ablation power supply
US11786725B2 (en) 2012-06-13 2023-10-17 Mainstay Medical Limited Systems and methods for restoring muscle function to the lumbar spine and kits for implanting the same
US11684774B2 (en) * 2010-03-11 2023-06-27 Mainstay Medical Limited Electrical stimulator for treatment of back pain and methods of use
US8740898B2 (en) * 2010-03-22 2014-06-03 Covidien Lp Surgical forceps
AU2011232335A1 (en) 2010-03-24 2012-10-11 Shifamed Holdings, Llc Intravascular tissue disruption
KR20130108067A (ko) 2010-04-09 2013-10-02 베식스 바스큘라 인코포레이티드 조직 치료를 위한 발전 및 제어 장치
US9192790B2 (en) 2010-04-14 2015-11-24 Boston Scientific Scimed, Inc. Focused ultrasonic renal denervation
WO2011130534A2 (en) * 2010-04-14 2011-10-20 Boston Scientific Scimed, Inc. Renal artery denervation apparatus employing helical shaping arrangement
US8870863B2 (en) 2010-04-26 2014-10-28 Medtronic Ardian Luxembourg S.A.R.L. Catheter apparatuses, systems, and methods for renal neuromodulation
CN103096826B (zh) * 2010-04-26 2016-07-20 美敦力阿迪安卢森堡有限公司 用于肾神经调节的导管设备、系统和方法
CN105105844B (zh) 2010-05-12 2017-12-15 施菲姆德控股有限责任公司 小轮廓的电极组件
US9655677B2 (en) 2010-05-12 2017-05-23 Shifamed Holdings, Llc Ablation catheters including a balloon and electrodes
WO2011150200A2 (en) * 2010-05-26 2011-12-01 University Of Miami Non occluding firing catheter for prolonged drug delivery
US8473067B2 (en) 2010-06-11 2013-06-25 Boston Scientific Scimed, Inc. Renal denervation and stimulation employing wireless vascular energy transfer arrangement
US9155589B2 (en) 2010-07-30 2015-10-13 Boston Scientific Scimed, Inc. Sequential activation RF electrode set for renal nerve ablation
US20120029512A1 (en) * 2010-07-30 2012-02-02 Willard Martin R Balloon with surface electrodes and integral cooling for renal nerve ablation
US9084609B2 (en) 2010-07-30 2015-07-21 Boston Scientific Scime, Inc. Spiral balloon catheter for renal nerve ablation
US9358365B2 (en) 2010-07-30 2016-06-07 Boston Scientific Scimed, Inc. Precision electrode movement control for renal nerve ablation
US9463062B2 (en) 2010-07-30 2016-10-11 Boston Scientific Scimed, Inc. Cooled conductive balloon RF catheter for renal nerve ablation
US9408661B2 (en) 2010-07-30 2016-08-09 Patrick A. Haverkost RF electrodes on multiple flexible wires for renal nerve ablation
US9554725B2 (en) * 2010-08-03 2017-01-31 Medtronic Monitoring, Inc. Medical device and methods of monitoring a patient with renal dysfunction
WO2012019156A1 (en) 2010-08-05 2012-02-09 Medtronic Ardian Luxembourg S.A.R.L. Cryoablation apparatuses, systems, and methods for renal neuromodulation
US9943353B2 (en) 2013-03-15 2018-04-17 Tsunami Medtech, Llc Medical system and method of use
US8934956B2 (en) * 2010-08-31 2015-01-13 Interventional Autonomics Corporation Intravascular electrodes and anchoring devices for transvascular stimulation
US20150150508A1 (en) * 2010-08-31 2015-06-04 Interventional Autonomics Corporation Intravascular electrodes and anchoring devices for transvascular stimulation
WO2012051433A2 (en) 2010-10-13 2012-04-19 Angiodynamics, Inc. System and method for electrically ablating tissue of a patient
US8585601B2 (en) 2010-10-18 2013-11-19 CardioSonic Ltd. Ultrasound transducer
US9566456B2 (en) 2010-10-18 2017-02-14 CardioSonic Ltd. Ultrasound transceiver and cooling thereof
EP2661304A1 (en) * 2010-10-18 2013-11-13 Cardiosonic Ltd. Therapeutics reservoir
WO2012052924A1 (en) * 2010-10-18 2012-04-26 CardioSonic Ltd. Separation device for ultrasound element
US9028417B2 (en) 2010-10-18 2015-05-12 CardioSonic Ltd. Ultrasound emission element
ES2751156T3 (es) * 2010-10-20 2020-03-30 Medtronic Ardian Luxembourg Aparatos de catéter que tienen estructuras de malla expansibles para neuromodulación renal
TWI556849B (zh) 2010-10-21 2016-11-11 美敦力阿福盧森堡公司 用於腎臟神經協調的導管裝置
EP3449856B1 (en) 2010-10-25 2023-06-28 Medtronic Ardian Luxembourg S.à.r.l. Device for evaluation and feedback of neuromodulation treatment
CN103179914B (zh) * 2010-10-25 2016-11-09 美敦力Af卢森堡有限责任公司 用于肾神经调节的微波导管设备
US8974451B2 (en) * 2010-10-25 2015-03-10 Boston Scientific Scimed, Inc. Renal nerve ablation using conductive fluid jet and RF energy
MX2013004235A (es) * 2010-10-25 2013-05-30 Medtronic Ardian Luxembourg Aparatos de cateter que tienen arreglos de multiples electrodos para neuromodulacion renal y sistemas y metodos asociados.
US9060754B2 (en) 2010-10-26 2015-06-23 Medtronic Ardian Luxembourg S.A.R.L. Neuromodulation cryotherapeutic devices and associated systems and methods
US20120143294A1 (en) 2010-10-26 2012-06-07 Medtronic Adrian Luxembourg S.a.r.l. Neuromodulation cryotherapeutic devices and associated systems and methods
US20120109021A1 (en) * 2010-10-27 2012-05-03 Roger Hastings Renal denervation catheter employing acoustic wave generator arrangement
US9220558B2 (en) 2010-10-27 2015-12-29 Boston Scientific Scimed, Inc. RF renal denervation catheter with multiple independent electrodes
WO2012064864A1 (en) 2010-11-09 2012-05-18 Aegea Medical Inc. Positioning method and apparatus for delivering vapor to the uterus
US9028485B2 (en) 2010-11-15 2015-05-12 Boston Scientific Scimed, Inc. Self-expanding cooling electrode for renal nerve ablation
US9668811B2 (en) 2010-11-16 2017-06-06 Boston Scientific Scimed, Inc. Minimally invasive access for renal nerve ablation
US9089350B2 (en) 2010-11-16 2015-07-28 Boston Scientific Scimed, Inc. Renal denervation catheter with RF electrode and integral contrast dye injection arrangement
US9326751B2 (en) 2010-11-17 2016-05-03 Boston Scientific Scimed, Inc. Catheter guidance of external energy for renal denervation
EP4137199A1 (en) * 2010-11-17 2023-02-22 Medtronic Ireland Manufacturing Unlimited Company Systems for therapeutic renal neuromodulation for treating dyspnea
US9060761B2 (en) 2010-11-18 2015-06-23 Boston Scientific Scime, Inc. Catheter-focused magnetic field induced renal nerve ablation
JP6078471B2 (ja) 2010-11-19 2017-02-08 セント・ジュード・メディカル・エイトリアル・フィブリレーション・ディヴィジョン・インコーポレーテッド 直流組織治療のための不関電極を有する電極カテーテル機器
CN103327921B (zh) * 2010-11-19 2017-02-15 波士顿科学西美德公司 肾神经检测以及消融装置
US9192435B2 (en) 2010-11-22 2015-11-24 Boston Scientific Scimed, Inc. Renal denervation catheter with cooled RF electrode
US9023034B2 (en) 2010-11-22 2015-05-05 Boston Scientific Scimed, Inc. Renal ablation electrode with force-activatable conduction apparatus
US9770319B2 (en) 2010-12-01 2017-09-26 Surefire Medical, Inc. Closed tip dynamic microvalve protection device
US20120157992A1 (en) * 2010-12-15 2012-06-21 Scott Smith Off-wall electrode device for renal nerve ablation
US10016233B2 (en) * 2010-12-06 2018-07-10 Biosense Webster (Israel) Ltd. Treatment of atrial fibrillation using high-frequency pacing and ablation of renal nerves
US20120157993A1 (en) 2010-12-15 2012-06-21 Jenson Mark L Bipolar Off-Wall Electrode Device for Renal Nerve Ablation
US20120232409A1 (en) * 2010-12-15 2012-09-13 Stahmann Jeffrey E System and method for renal artery occlusion during renal denervation therapy
WO2012086492A1 (ja) 2010-12-21 2012-06-28 テルモ株式会社 バルーンカテーテル及び通電システム
DK2658605T3 (en) * 2010-12-28 2016-11-14 Cibiem Inc CATH for endovascular ablation of glomus CAROTICUM FOR RESTORING sympathetic BALANCE WITH PATIENT
US9220561B2 (en) 2011-01-19 2015-12-29 Boston Scientific Scimed, Inc. Guide-compatible large-electrode catheter for renal nerve ablation with reduced arterial injury
US10092291B2 (en) 2011-01-25 2018-10-09 Ethicon Endo-Surgery, Inc. Surgical instrument with selectively rigidizable features
US20140163540A1 (en) 2011-02-18 2014-06-12 Recor Medical, Inc. Apparatus for effecting renal denervation using ultrasound
US9233241B2 (en) 2011-02-28 2016-01-12 Ethicon Endo-Surgery, Inc. Electrical ablation devices and methods
US9254169B2 (en) * 2011-02-28 2016-02-09 Ethicon Endo-Surgery, Inc. Electrical ablation devices and methods
US9314620B2 (en) 2011-02-28 2016-04-19 Ethicon Endo-Surgery, Inc. Electrical ablation devices and methods
WO2012122157A1 (en) * 2011-03-07 2012-09-13 Tidal Wave Technology, Inc. Radiofrequency ablation catheter device
US20140012251A1 (en) * 2011-03-07 2014-01-09 Tidal Wave Technology, Inc. Ablation devices and methods
US9049987B2 (en) 2011-03-17 2015-06-09 Ethicon Endo-Surgery, Inc. Hand held surgical device for manipulating an internal magnet assembly within a patient
EP2677953A4 (en) * 2011-03-31 2014-10-08 Tidal Wave Technology Inc RADIO FREQUENCY ABLATION CATHETER DEVICE
WO2012135786A2 (en) * 2011-04-01 2012-10-04 The Regents Of The University Of California Cryoelectric systems and methods for treatment of biological matter
WO2012161875A1 (en) 2011-04-08 2012-11-29 Tyco Healthcare Group Lp Iontophoresis drug delivery system and method for denervation of the renal sympathetic nerve and iontophoretic drug delivery
US8663190B2 (en) 2011-04-22 2014-03-04 Ablative Solutions, Inc. Expandable catheter system for peri-ostial injection and muscle and nerve fiber ablation
US9237925B2 (en) 2011-04-22 2016-01-19 Ablative Solutions, Inc. Expandable catheter system for peri-ostial injection and muscle and nerve fiber ablation
WO2012148969A2 (en) 2011-04-25 2012-11-01 Brian Kelly Apparatus and methods related to constrained deployment of cryogenic balloons for limited cryogenic ablation of vessel walls
EP2701795B1 (en) 2011-04-28 2020-12-09 Interventional Autonomics Corporation Neuromodulation systems for treating acute heart failure syndromes
CN102274074A (zh) * 2011-05-03 2011-12-14 上海微创电生理医疗科技有限公司 多极开放式射频消融导管
WO2012151396A2 (en) 2011-05-03 2012-11-08 Shifamed Holdings, Llc Steerable delivery sheaths
US20120323233A1 (en) 2011-05-09 2012-12-20 Cyberheart, Inc. Renovascular treatment device, system, and method for radiosurgically alleviating hypertension
US20120290024A1 (en) * 2011-05-11 2012-11-15 St. Jude Medical, Inc. Transvenous renal nerve modulation for treatment of hypertension, cardiovascular disorders, and chronic renal diseases
US8909316B2 (en) 2011-05-18 2014-12-09 St. Jude Medical, Cardiology Division, Inc. Apparatus and method of assessing transvascular denervation
EP2709517B1 (en) * 2011-05-18 2017-01-11 St. Jude Medical, Inc. Apparatus for assessing transvascular denervation
US9220433B2 (en) 2011-06-30 2015-12-29 Biosense Webster (Israel), Ltd. Catheter with variable arcuate distal section
JP6095658B2 (ja) * 2011-07-11 2017-03-15 インターベンショナル オートノミックス コーポレーション 神経変調療法のためのシステムおよび方法
US20130072995A1 (en) 2011-07-11 2013-03-21 Terrance Ransbury Catheter system for acute neuromodulation
US9446240B2 (en) 2011-07-11 2016-09-20 Interventional Autonomics Corporation System and method for neuromodulation
CN103987334A (zh) * 2011-07-12 2014-08-13 沃夫医药公司 经由肾盂的肾神经去神经支配
WO2013013156A2 (en) 2011-07-20 2013-01-24 Boston Scientific Scimed, Inc. Percutaneous devices and methods to visualize, target and ablate nerves
JP6106669B2 (ja) 2011-07-22 2017-04-05 ボストン サイエンティフィック サイムド，インコーポレイテッドＢｏｓｔｏｎ Ｓｃｉｅｎｔｉｆｉｃ Ｓｃｉｍｅｄ，Ｉｎｃ． ヘリカル・ガイド内に配置可能な神経調節要素を有する神経調節システム
US20130030430A1 (en) 2011-07-29 2013-01-31 Stewart Mark T Intracardiac tools and methods for delivery of electroporation therapies
US9662169B2 (en) 2011-07-30 2017-05-30 Biosense Webster (Israel) Ltd. Catheter with flow balancing valve
US20130165921A1 (en) * 2011-08-24 2013-06-27 Boston Scientific Scimed, Inc. Device and methods for nerve modulation
US9278196B2 (en) 2011-08-24 2016-03-08 Ablative Solutions, Inc. Expandable catheter system for vessel wall injection and muscle and nerve fiber ablation
US20130053732A1 (en) * 2011-08-24 2013-02-28 Richard R. Heuser Devices and methods for treating hypertension with energy
US20130053792A1 (en) 2011-08-24 2013-02-28 Ablative Solutions, Inc. Expandable catheter system for vessel wall injection and muscle and nerve fiber ablation
US9056185B2 (en) 2011-08-24 2015-06-16 Ablative Solutions, Inc. Expandable catheter system for fluid injection into and deep to the wall of a blood vessel
US8702619B2 (en) 2011-08-26 2014-04-22 Symap Holding Limited Mapping sympathetic nerve distribution for renal ablation and catheters for same
CN102949176B (zh) * 2011-08-26 2014-11-12 苏州信迈医疗器械有限公司 肾神经消融术中肾神经分布标测方法及用于该方法的导管
SG2014013957A (en) 2011-08-26 2014-03-28 Symap Holding Ltd System and method for locating and identifying functional nerves innervating wall of arteries and catheters for same
US9820811B2 (en) * 2011-08-26 2017-11-21 Symap Medical (Suzhou), Ltd System and method for mapping the functional nerves innervating the wall of arteries, 3-D mapping and catheters for same
US9089668B2 (en) 2011-09-28 2015-07-28 Surefire Medical, Inc. Flow directional infusion device
US9078665B2 (en) 2011-09-28 2015-07-14 Angiodynamics, Inc. Multiple treatment zone ablation probe
US9427579B2 (en) 2011-09-29 2016-08-30 Pacesetter, Inc. System and method for performing renal denervation verification
US20130090637A1 (en) * 2011-10-05 2013-04-11 St. Jude Medical, Inc. Catheter device and method for denervation
US8696584B2 (en) 2011-10-05 2014-04-15 3Dt Holdings, Llc Devices, systems and methods for determining fractional flow reserve in the presence of a catheter
EP2763617B1 (en) 2011-10-07 2017-12-06 Aegea Medical Inc. Integrity testing apparatus for delivering vapor to the uterus
EP2765942B1 (en) * 2011-10-10 2016-02-24 Boston Scientific Scimed, Inc. Medical devices including ablation electrodes
EP2765940B1 (en) * 2011-10-11 2015-08-26 Boston Scientific Scimed, Inc. Off-wall electrode device for nerve modulation
US9420955B2 (en) 2011-10-11 2016-08-23 Boston Scientific Scimed, Inc. Intravascular temperature monitoring system and method
US9364284B2 (en) * 2011-10-12 2016-06-14 Boston Scientific Scimed, Inc. Method of making an off-wall spacer cage
EP2768568B1 (en) 2011-10-18 2020-05-06 Boston Scientific Scimed, Inc. Integrated crossing balloon catheter
EP2768563B1 (en) 2011-10-18 2016-11-09 Boston Scientific Scimed, Inc. Deflectable medical devices
US20130116737A1 (en) * 2011-11-07 2013-05-09 Medtronic Ardian Luxembourg S.A.R.L. Methods for Assessing Renal Neuromodulation Treatment and Associated Systems and Methods
US9327123B2 (en) 2011-11-07 2016-05-03 Medtronic Ardian Luxembourg S.A.R.L. Endovascular nerve monitoring devices and associated systems and methods
WO2013070724A1 (en) * 2011-11-08 2013-05-16 Boston Scientific Scimed, Inc. Ostial renal nerve ablation
US20130116683A1 (en) * 2011-11-09 2013-05-09 Tsunami Medtech, Llc Medical system and method of use
EP2779929A1 (en) 2011-11-15 2014-09-24 Boston Scientific Scimed, Inc. Device and methods for renal nerve modulation monitoring
US9119632B2 (en) 2011-11-21 2015-09-01 Boston Scientific Scimed, Inc. Deflectable renal nerve ablation catheter
WO2013077283A1 (ja) * 2011-11-21 2013-05-30 国立大学法人大阪大学 腎動脈アブレーション用のカテーテルおよびシステム
GB201120023D0 (en) * 2011-11-21 2012-01-04 Univ Dundee Radio frequency surgical probe
US9192766B2 (en) 2011-12-02 2015-11-24 Medtronic Ardian Luxembourg S.A.R.L. Renal neuromodulation methods and devices for treatment of polycystic kidney disease
ITPD20110383A1 (it) * 2011-12-05 2013-06-06 Cardiac Impulse Srl Elettrocatetere per neurostimolazione
JP6441679B2 (ja) * 2011-12-09 2018-12-19 メタベンション インコーポレイテッド 肝臓系の治療的な神経調節
US9844405B2 (en) 2011-12-20 2017-12-19 Cardiac Pacemakers, Inc. Method and apparatus for monitoring and ablating nerves
US9265969B2 (en) 2011-12-21 2016-02-23 Cardiac Pacemakers, Inc. Methods for modulating cell function
WO2013096920A1 (en) 2011-12-23 2013-06-27 Vessix Vascular, Inc. Methods and apparatuses for remodeling tissue of or adjacent to a body passage
WO2013101452A1 (en) 2011-12-28 2013-07-04 Boston Scientific Scimed, Inc. Device and methods for nerve modulation using a novel ablation catheter with polymeric ablative elements
US9050106B2 (en) 2011-12-29 2015-06-09 Boston Scientific Scimed, Inc. Off-wall electrode device and methods for nerve modulation
CN104159535A (zh) * 2012-01-17 2014-11-19 波士顿科学西美德公司 肾神经调节装置以及用于制造和使用该装置的方法
WO2013116380A1 (en) 2012-01-30 2013-08-08 Vytronus, Inc. Tissue necrosis methods and apparatus
US9414881B2 (en) 2012-02-08 2016-08-16 Angiodynamics, Inc. System and method for increasing a target zone for electrical ablation
US8986199B2 (en) 2012-02-17 2015-03-24 Ethicon Endo-Surgery, Inc. Apparatus and methods for cleaning the lens of an endoscope
US9089341B2 (en) 2012-02-28 2015-07-28 Surefire Medical, Inc. Renal nerve neuromodulation device
CN104159536A (zh) * 2012-03-01 2014-11-19 波士顿科学西美德公司 用于神经调制的离壁和接触电极装置以及方法
EP4070850A1 (en) 2012-03-05 2022-10-12 Lungpacer Medical Inc. Transvascular nerve stimulation apparatus and methods
AU2013202803C1 (en) * 2012-03-07 2016-06-23 Reshape Lifesciences, Inc. Devices for regulation of blood pressure and heart rate
CN104254367A (zh) * 2012-03-07 2014-12-31 美敦力阿迪安卢森堡有限公司 肾神经的选择性调制
AU2013230776B2 (en) * 2012-03-08 2015-12-03 Medtronic Af Luxembourg S.A.R.L. Immune system neuromodulation and associated systems and methods
US9883909B2 (en) 2012-03-08 2018-02-06 Medtronic Ardian Luxembourg S.A.R.L. Renal neuromodulation methods and systems for treatment of hyperaldosteronism
AU2013230781B2 (en) 2012-03-08 2015-12-03 Medtronic Af Luxembourg S.A.R.L. Ovarian neuromodulation and associated systems and methods
WO2013134492A1 (en) 2012-03-08 2013-09-12 Medtronic Ardian Luxembourg Sarl Neuromodulation and associated systems and methods for the treatment of sexual dysfunction
WO2013134541A2 (en) 2012-03-08 2013-09-12 Medtronic Ardian Luxembourg Sarl Gastrointestinal neuromodulation and associated systems and methods
US9510777B2 (en) * 2012-03-08 2016-12-06 Medtronic Ardian Luxembourg S.A.R.L. Monitoring of neuromodulation using biomarkers
AU2013230893B2 (en) 2012-03-08 2015-12-03 Medtronic Af Luxembourg S.A.R.L. Neuromodulation and associated systems and methods for the management of pain
US8934988B2 (en) 2012-03-16 2015-01-13 St. Jude Medical Ab Ablation stent with meander structure
JP2013198691A (ja) * 2012-03-26 2013-10-03 Olympus Corp 神経刺激電極および神経刺激システム
JP5936409B2 (ja) * 2012-03-26 2016-06-22 国立研究開発法人国立循環器病研究センター 電極ユニットおよび組織刺激システム
US9439598B2 (en) 2012-04-12 2016-09-13 NeuroMedic, Inc. Mapping and ablation of nerves within arteries and tissues
US9259261B2 (en) * 2012-04-12 2016-02-16 Vanderbilt University Ablation catheter having temperature-controlled anchor and related methods
US8961550B2 (en) 2012-04-17 2015-02-24 Indian Wells Medical, Inc. Steerable endoluminal punch
WO2013157011A2 (en) 2012-04-18 2013-10-24 CardioSonic Ltd. Tissue treatment
US9113929B2 (en) 2012-04-19 2015-08-25 St. Jude Medical, Cardiology Division, Inc. Non-electric field renal denervation electrode
US9393070B2 (en) 2012-04-24 2016-07-19 Cibiem, Inc. Endovascular catheters and methods for carotid body ablation
US9241752B2 (en) 2012-04-27 2016-01-26 Medtronic Ardian Luxembourg S.A.R.L. Shafts with pressure relief in cryotherapeutic catheters and associated devices, systems, and methods
US9848950B2 (en) 2012-04-27 2017-12-26 Medtronic Ardian Luxembourg S.A.R.L. Methods and devices for localized disease treatment by ablation
US10258791B2 (en) 2012-04-27 2019-04-16 Medtronic Ardian Luxembourg S.A.R.L. Catheter assemblies for neuromodulation proximate a bifurcation of a renal artery and associated systems and methods
US20150088113A1 (en) 2012-04-27 2015-03-26 Medtronic Ardian Luxembourg S.A.R.L. Cryotherapeutic devices for renal neuromodulation and associated systems and methods
WO2013162721A1 (en) 2012-04-27 2013-10-31 Medtronic Ardian Luxembourg Sarl Methods and devices for localized inhibition of inflammation by ablation
US20130289686A1 (en) * 2012-04-29 2013-10-31 Synecor Llc Intravascular electrode arrays for neuromodulation
US11395921B2 (en) 2012-04-29 2022-07-26 Nuxcel2 Llc Intravascular electrode arrays for neuromodulation
WO2013165935A1 (en) * 2012-05-03 2013-11-07 Sound Interventions, Inc. Apparatus and method for uniform renal denervation
US10660703B2 (en) 2012-05-08 2020-05-26 Boston Scientific Scimed, Inc. Renal nerve modulation devices
US9439722B2 (en) 2012-05-09 2016-09-13 Biosense Webster (Israel) Ltd. Ablation targeting nerves in or near the inferior vena cava and/or abdominal aorta for treatment of hypertension
US9717555B2 (en) 2012-05-14 2017-08-01 Biosense Webster (Israel), Ltd. Catheter with helical end section for vessel ablation
ES2614272T3 (es) 2012-05-11 2017-05-30 Medtronic Ardian Luxembourg S.à.r.l. Conjuntos de catéter de múltiples electrodos para neuromodulación renal y sistemas y métodos asociados
US9427255B2 (en) 2012-05-14 2016-08-30 Ethicon Endo-Surgery, Inc. Apparatus for introducing a steerable camera assembly into a patient
US11357447B2 (en) 2012-05-31 2022-06-14 Sonivie Ltd. Method and/or apparatus for measuring renal denervation effectiveness
WO2013181660A1 (en) 2012-06-01 2013-12-05 Cibiem, Inc. Methods and devices for cryogenic carotid body ablation
CA3184524A1 (en) * 2012-06-14 2013-12-19 Autonomix Medical, Inc. Devices, systems, and methods for diagnosis and treatment of overactive bladder
CA2877049C (en) 2012-06-21 2022-08-16 Simon Fraser University Transvascular diaphragm pacing systems and methods of use
US8951296B2 (en) 2012-06-29 2015-02-10 Medtronic Ardian Luxembourg S.A.R.L. Devices and methods for photodynamically modulating neural function in a human
US9955946B2 (en) 2014-03-12 2018-05-01 Cibiem, Inc. Carotid body ablation with a transvenous ultrasound imaging and ablation catheter
US9078662B2 (en) 2012-07-03 2015-07-14 Ethicon Endo-Surgery, Inc. Endoscopic cap electrode and method for using the same
US9295842B2 (en) 2012-07-05 2016-03-29 Mc10, Inc. Catheter or guidewire device including flow sensing and use thereof
US9168094B2 (en) * 2012-07-05 2015-10-27 Mc10, Inc. Catheter device including flow sensing
US9381063B2 (en) 2012-07-13 2016-07-05 Magnetecs Inc. Method and apparatus for magnetically guided catheter for renal denervation employing MOSFET sensor array
EP2874555A1 (en) * 2012-07-17 2015-05-27 Boston Scientific Scimed, Inc. Renal nerve modulation catheter design
US9144459B2 (en) 2012-07-19 2015-09-29 Cook Medical Technologies Llc Endoscopic ultrasound ablation needle
EP3064249A3 (en) * 2012-07-24 2016-09-14 Clearstream Technologies Limited Balloon catheter with enhanced locatability
US9545290B2 (en) 2012-07-30 2017-01-17 Ethicon Endo-Surgery, Inc. Needle probe guide
US10314649B2 (en) * 2012-08-02 2019-06-11 Ethicon Endo-Surgery, Inc. Flexible expandable electrode and method of intraluminal delivery of pulsed power
US9572623B2 (en) 2012-08-02 2017-02-21 Ethicon Endo-Surgery, Inc. Reusable electrode and disposable sheath
US9861802B2 (en) 2012-08-09 2018-01-09 University Of Iowa Research Foundation Catheters, catheter systems, and methods for puncturing through a tissue structure
US9277957B2 (en) 2012-08-15 2016-03-08 Ethicon Endo-Surgery, Inc. Electrosurgical devices and methods
CN103584909B (zh) * 2012-08-17 2016-01-27 王涛 开放式网状射频消融电极
US20140058372A1 (en) * 2012-08-22 2014-02-27 Amir Belson Treatment for renal failure
CN203138452U (zh) * 2012-08-24 2013-08-21 苏州信迈医疗器械有限公司 一种能够定位或识别位于血管壁内或外膜上的神经的仪器
CN102784006B (zh) * 2012-08-24 2015-11-25 邹英华 用于治疗高血压的射频消融电极
US10321946B2 (en) 2012-08-24 2019-06-18 Boston Scientific Scimed, Inc. Renal nerve modulation devices with weeping RF ablation balloons
US9849025B2 (en) 2012-09-07 2017-12-26 Yale University Brain cooling system
US8612022B1 (en) * 2012-09-13 2013-12-17 Invatec S.P.A. Neuromodulation catheters and associated systems and methods
JP2014054430A (ja) 2012-09-13 2014-03-27 Nippon Koden Corp カテーテル
CN104780859B (zh) * 2012-09-17 2017-07-25 波士顿科学西美德公司 用于肾神经调节的自定位电极系统及方法
WO2014047355A1 (en) 2012-09-19 2014-03-27 Denervx LLC Cooled microwave denervation
US10549127B2 (en) 2012-09-21 2020-02-04 Boston Scientific Scimed, Inc. Self-cooling ultrasound ablation catheter
US10398464B2 (en) 2012-09-21 2019-09-03 Boston Scientific Scimed, Inc. System for nerve modulation and innocuous thermal gradient nerve block
CN104869930B (zh) * 2012-10-10 2020-12-25 波士顿科学国际有限公司 肾神经调制装置和方法
US20140110296A1 (en) 2012-10-19 2014-04-24 Medtronic Ardian Luxembourg S.A.R.L. Packaging for Catheter Treatment Devices and Associated Devices, Systems, and Methods
US20140114215A1 (en) * 2012-10-20 2014-04-24 Medtronic Ardian Luxembourg S.A.R.L. Methods for Renal Neuromodulation and Associated Systems and Devices
US9044575B2 (en) 2012-10-22 2015-06-02 Medtronic Adrian Luxembourg S.a.r.l. Catheters with enhanced flexibility and associated devices, systems, and methods
CN108310589A (zh) 2012-10-22 2018-07-24 美敦力Af卢森堡有限责任公司 具有改善的柔性的导管
US8740849B1 (en) 2012-10-29 2014-06-03 Ablative Solutions, Inc. Peri-vascular tissue ablation catheter with support structures
US9301795B2 (en) 2012-10-29 2016-04-05 Ablative Solutions, Inc. Transvascular catheter for extravascular delivery
US10226278B2 (en) 2012-10-29 2019-03-12 Ablative Solutions, Inc. Method for painless renal denervation using a peri-vascular tissue ablation catheter with support structures
US10736656B2 (en) 2012-10-29 2020-08-11 Ablative Solutions Method for painless renal denervation using a peri-vascular tissue ablation catheter with support structures
US10881458B2 (en) 2012-10-29 2021-01-05 Ablative Solutions, Inc. Peri-vascular tissue ablation catheters
US9526827B2 (en) 2012-10-29 2016-12-27 Ablative Solutions, Inc. Peri-vascular tissue ablation catheter with support structures
US10945787B2 (en) 2012-10-29 2021-03-16 Ablative Solutions, Inc. Peri-vascular tissue ablation catheters
US9554849B2 (en) 2012-10-29 2017-01-31 Ablative Solutions, Inc. Transvascular method of treating hypertension
CN105263431A (zh) 2012-11-02 2016-01-20 纽敦力公司 用于多种疾病治疗的化学消融制剂和方法
CN104902836B (zh) 2012-11-05 2017-08-08 毕达哥拉斯医疗有限公司 受控组织消融
US9770593B2 (en) 2012-11-05 2017-09-26 Pythagoras Medical Ltd. Patient selection using a transluminally-applied electric current
US9095321B2 (en) 2012-11-21 2015-08-04 Medtronic Ardian Luxembourg S.A.R.L. Cryotherapeutic devices having integral multi-helical balloons and methods of making the same
US9017317B2 (en) 2012-12-06 2015-04-28 Medtronic Ardian Luxembourg S.A.R.L. Refrigerant supply system for cryotherapy including refrigerant recompression and associated devices, systems, and methods
US20140172034A1 (en) * 2012-12-18 2014-06-19 Pacesetter, Inc. Intra-cardiac implantable medical device with ic device extension for lv pacing/sensing
WO2014096969A2 (en) * 2012-12-19 2014-06-26 Adi Mashiach Systems and methods for hypertension control
TW201438660A (zh) 2012-12-20 2014-10-16 Shlomo Ben-Haim 多點治療探針及其使用方法
US9398933B2 (en) 2012-12-27 2016-07-26 Holaira, Inc. Methods for improving drug efficacy including a combination of drug administration and nerve modulation
US10537286B2 (en) * 2013-01-08 2020-01-21 Biosense Webster (Israel) Ltd. Catheter with multiple spines of different lengths arranged in one or more distal assemblies
WO2014113724A2 (en) 2013-01-17 2014-07-24 Sharma Virender K Method and apparatus for tissue ablation
EP2945683A4 (en) * 2013-01-18 2017-03-15 SRI International Anchoring nerve block catheter
US9888956B2 (en) 2013-01-22 2018-02-13 Angiodynamics, Inc. Integrated pump and generator device and method of use
EP2759314A1 (de) * 2013-01-28 2014-07-30 Biotronik AG Katheter zur Modulation der renalen Nerven
US20140228875A1 (en) 2013-02-08 2014-08-14 Nidus Medical, Llc Surgical device with integrated visualization and cauterization
US10098527B2 (en) 2013-02-27 2018-10-16 Ethidcon Endo-Surgery, Inc. System for performing a minimally invasive surgical procedure
US20140303617A1 (en) * 2013-03-05 2014-10-09 Neuro Ablation, Inc. Intravascular nerve ablation devices & methods
US9179997B2 (en) 2013-03-06 2015-11-10 St. Jude Medical, Cardiology Division, Inc. Thermochromic polyvinyl alcohol based hydrogel artery
US10076384B2 (en) 2013-03-08 2018-09-18 Symple Surgical, Inc. Balloon catheter apparatus with microwave emitter
WO2015061621A1 (en) * 2013-10-24 2015-04-30 Medtronic Ardian Luxembourg S.A.R.L. Catheter apparatuses for pulmonary artery neuromodulation
WO2014163987A1 (en) 2013-03-11 2014-10-09 Boston Scientific Scimed, Inc. Medical devices for modulating nerves
US9693821B2 (en) 2013-03-11 2017-07-04 Boston Scientific Scimed, Inc. Medical devices for modulating nerves
US9775966B2 (en) 2013-03-12 2017-10-03 St. Jude Medical, Cardiology Division, Inc. Catheter system
EP2777739B1 (en) 2013-03-12 2018-09-05 St. Jude Medical, Cardiology Division, Inc. Catheter system
US10328238B2 (en) 2013-03-12 2019-06-25 St. Jude Medical, Cardiology Division, Inc. Catheter system
US9861431B2 (en) * 2013-03-13 2018-01-09 Kyphon SÀRL Radiofrequency inflatable device
US9510902B2 (en) 2013-03-13 2016-12-06 St. Jude Medical, Cardiology Division, Inc. Ablation catheters and systems including rotational monitoring means
US9808311B2 (en) 2013-03-13 2017-11-07 Boston Scientific Scimed, Inc. Deflectable medical devices
US9131982B2 (en) 2013-03-14 2015-09-15 St. Jude Medical, Cardiology Division, Inc. Mediguide-enabled renal denervation system for ensuring wall contact and mapping lesion locations
EP2968984B1 (en) 2013-03-14 2016-08-17 ReCor Medical, Inc. Ultrasound-based neuromodulation system
US8876813B2 (en) 2013-03-14 2014-11-04 St. Jude Medical, Inc. Methods, systems, and apparatus for neural signal detection
WO2014159273A1 (en) 2013-03-14 2014-10-02 Recor Medical, Inc. Methods of plating or coating ultrasound transducers
EP2967734B1 (en) 2013-03-15 2019-05-15 Boston Scientific Scimed, Inc. Methods and apparatuses for remodeling tissue of or adjacent to a body passage
US9974477B2 (en) 2013-03-15 2018-05-22 St. Jude Medical, Cardiology Division, Inc. Quantification of renal denervation via alterations in renal blood flow pre/post ablation
US9186212B2 (en) 2013-03-15 2015-11-17 St. Jude Medical, Cardiology Division, Inc. Feedback systems and methods utilizing two or more sites along denervation catheter
US9610112B2 (en) 2013-03-15 2017-04-04 Myoscience, Inc. Cryogenic enhancement of joint function, alleviation of joint stiffness and/or alleviation of pain associated with osteoarthritis
US9295512B2 (en) 2013-03-15 2016-03-29 Myoscience, Inc. Methods and devices for pain management
US9066726B2 (en) 2013-03-15 2015-06-30 Medtronic Ardian Luxembourg S.A.R.L. Multi-electrode apposition judgment using pressure elements
US9668800B2 (en) 2013-03-15 2017-06-06 Myoscience, Inc. Methods and systems for treatment of spasticity
US10265122B2 (en) 2013-03-15 2019-04-23 Boston Scientific Scimed, Inc. Nerve ablation devices and related methods of use
EP3345564A1 (en) 2013-03-15 2018-07-11 St. Jude Medical, Cardiology Division, Inc. Multi-electrode ablation system with a controller for determining a thermal gain of each electrode
US9179973B2 (en) 2013-03-15 2015-11-10 St. Jude Medical, Cardiology Division, Inc. Feedback systems and methods for renal denervation utilizing balloon catheter
WO2014149690A2 (en) 2013-03-15 2014-09-25 Boston Scientific Scimed, Inc. Medical devices and methods for treatment of hypertension that utilize impedance compensation
EP4233991A1 (en) 2013-03-15 2023-08-30 Medtronic Ardian Luxembourg S.à.r.l. Controlled neuromodulation systems
US9233247B2 (en) * 2013-03-15 2016-01-12 Boston Scientific Neuromodulation Corporation Neuromodulation of renal nerve for treatment of hypertension
US20140276767A1 (en) 2013-03-15 2014-09-18 St. Jude Medical, Cardiology Division, Inc. Ablation system, methods, and controllers
US9179974B2 (en) * 2013-03-15 2015-11-10 Medtronic Ardian Luxembourg S.A.R.L. Helical push wire electrode
US20140275993A1 (en) * 2013-03-15 2014-09-18 Medtronic Ardian Luxembourg S.a.r.I. Devices, Systems, and Methods for Specialization of Neuromodulation Treatment
US9173701B2 (en) 2013-03-15 2015-11-03 Warsaw Orthopedic, Inc. RF enabled inflatable bone tamp
US20140276756A1 (en) * 2013-03-15 2014-09-18 Boston Scientific Scimed, Inc. Wall-sparing renal nerve ablation catheter with spaced electrode structures
EP3510919A3 (en) 2013-03-27 2019-10-16 Autonomix Medical, Inc. Systems for neurological traffic and/or receptor functional evaluation and/or modification
US10098694B2 (en) 2013-04-08 2018-10-16 Apama Medical, Inc. Tissue ablation and monitoring thereof
CA2908517A1 (en) 2013-04-08 2014-10-16 Apama Medical, Inc. Cardiac ablation catheters and methods of use thereof
US10349824B2 (en) 2013-04-08 2019-07-16 Apama Medical, Inc. Tissue mapping and visualization systems
EP2986243B1 (en) 2013-04-15 2020-06-17 Mayo Foundation for Medical Education and Research Apparatus for percutaneous epicardial ablation of cardiac ganglionated plexi without myocardial injury
EP2988691B1 (en) 2013-04-25 2018-03-28 St. Jude Medical, Cardiology Division, Inc. Electrode assembly for catheter system
EP2991717A4 (en) * 2013-05-02 2016-12-07 Douglas C Harrington DEVICES AND METHODS FOR DETECTION AND TREATMENT OF AORTICO-RENAL GANGLION
WO2014189794A1 (en) 2013-05-18 2014-11-27 Medtronic Ardian Luxembourg S.A.R.L. Neuromodulation catheters with shafts for enhanced flexibility and control and associated devices, systems, and methods
US10390879B2 (en) * 2013-05-20 2019-08-27 Mayo Foundation For Medical Education And Research Devices and methods for ablation of tissue
WO2014188430A2 (en) 2013-05-23 2014-11-27 CardioSonic Ltd. Devices and methods for renal denervation and assessment thereof
US11229789B2 (en) 2013-05-30 2022-01-25 Neurostim Oab, Inc. Neuro activator with controller
JP2016523125A (ja) 2013-05-30 2016-08-08 グラハム エイチ． クリーシー 局所神経性刺激
WO2014197625A1 (en) * 2013-06-05 2014-12-11 Metavention, Inc. Modulation of targeted nerve fibers
EP3010581B1 (en) * 2013-06-18 2023-10-11 Nalu Medical, Inc. Apparatus for minimally invasive implantable modulators
JP2016523147A (ja) 2013-06-21 2016-08-08 ボストン サイエンティフィック サイムド，インコーポレイテッドＢｏｓｔｏｎ Ｓｃｉｅｎｔｉｆｉｃ Ｓｃｉｍｅｄ，Ｉｎｃ． 同乗型電極支持体を備えた腎除神経バルーンカテーテル
CN105473092B (zh) 2013-06-21 2019-05-17 波士顿科学国际有限公司 具有可旋转轴的用于肾神经消融的医疗器械
US9707036B2 (en) 2013-06-25 2017-07-18 Boston Scientific Scimed, Inc. Devices and methods for nerve modulation using localized indifferent electrodes
US9872728B2 (en) 2013-06-28 2018-01-23 St. Jude Medical, Cardiology Division, Inc. Apparatuses and methods for affixing electrodes to an intravascular balloon
AU2014284558B2 (en) 2013-07-01 2017-08-17 Boston Scientific Scimed, Inc. Medical devices for renal nerve ablation
US20150011991A1 (en) 2013-07-03 2015-01-08 St. Jude Medical, Cardiology Division, Inc. Electrode Assembly For Catheter System
US10660698B2 (en) 2013-07-11 2020-05-26 Boston Scientific Scimed, Inc. Devices and methods for nerve modulation
WO2015006573A1 (en) * 2013-07-11 2015-01-15 Boston Scientific Scimed, Inc. Medical device with stretchable electrode assemblies
CN105682594B (zh) 2013-07-19 2018-06-22 波士顿科学国际有限公司 螺旋双极电极肾脏去神经支配气囊
JP6122217B2 (ja) 2013-07-22 2017-04-26 ボストン サイエンティフィック サイムド，インコーポレイテッドＢｏｓｔｏｎ Ｓｃｉｅｎｔｉｆｉｃ Ｓｃｉｍｅｄ，Ｉｎｃ． 腎神経アブレーション用医療器具
EP3024406B1 (en) 2013-07-22 2019-06-19 Boston Scientific Scimed, Inc. Medical devices for renal nerve ablation
US20150031946A1 (en) 2013-07-24 2015-01-29 Nidus Medical, Llc Direct vision cryosurgical probe and methods of use
US10154869B2 (en) 2013-08-02 2018-12-18 Gary M. Onik System and method for creating radio-frequency energy electrical membrane breakdown for tissue ablation
WO2015022668A2 (en) * 2013-08-14 2015-02-19 La Vita Technologies Ltd. Methods and apparatuses for treating auto-immune diseases by ablative neuromodulation
US10722300B2 (en) 2013-08-22 2020-07-28 Boston Scientific Scimed, Inc. Flexible circuit having improved adhesion to a renal nerve modulation balloon
US9339332B2 (en) 2013-08-30 2016-05-17 Medtronic Ardian Luxembourg S.A.R.L. Neuromodulation catheters with nerve monitoring features for transmitting digital neural signals and associated systems and methods
US9326816B2 (en) 2013-08-30 2016-05-03 Medtronic Ardian Luxembourg S.A.R.L. Neuromodulation systems having nerve monitoring assemblies and associated devices, systems, and methods
EP3041425B1 (en) 2013-09-04 2022-04-13 Boston Scientific Scimed, Inc. Radio frequency (rf) balloon catheter having flushing and cooling capability
US20150073515A1 (en) 2013-09-09 2015-03-12 Medtronic Ardian Luxembourg S.a.r.I. Neuromodulation Catheter Devices and Systems Having Energy Delivering Thermocouple Assemblies and Associated Methods
US9138578B2 (en) 2013-09-10 2015-09-22 Medtronic Ardian Luxembourg S.A.R.L. Endovascular catheters with tuned control members and associated systems and methods
WO2015038947A1 (en) 2013-09-13 2015-03-19 Boston Scientific Scimed, Inc. Ablation balloon with vapor deposited cover layer
US9687288B2 (en) 2013-09-30 2017-06-27 Arrinex, Inc. Apparatus and methods for treating rhinitis
WO2015047817A1 (en) * 2013-09-30 2015-04-02 Medtronic Ardian Luxembourg S.A.R.L. Intravascular neuromodulation device having a spiral track and associated methods
CN105592778B (zh) 2013-10-14 2019-07-23 波士顿科学医学有限公司 高分辨率心脏标测电极阵列导管
US11246654B2 (en) 2013-10-14 2022-02-15 Boston Scientific Scimed, Inc. Flexible renal nerve ablation devices and related methods of use and manufacture
US9770606B2 (en) 2013-10-15 2017-09-26 Boston Scientific Scimed, Inc. Ultrasound ablation catheter with cooling infusion and centering basket
CN105636537B (zh) 2013-10-15 2018-08-17 波士顿科学国际有限公司 医疗器械球囊
WO2015057961A1 (en) 2013-10-18 2015-04-23 Boston Scientific Scimed, Inc. Balloon catheters with flexible conducting wires and related methods of use and manufacture
US10856936B2 (en) 2013-10-23 2020-12-08 St. Jude Medical, Cardiology Division, Inc. Electrode assembly for catheter system including thermoplastic-based struts
US10433902B2 (en) 2013-10-23 2019-10-08 Medtronic Ardian Luxembourg S.A.R.L. Current control methods and systems
USD914883S1 (en) 2013-10-23 2021-03-30 St. Jude Medical, Cardiology Division, Inc. Ablation generator
USD774043S1 (en) 2013-10-23 2016-12-13 St. Jude Medical, Cardiology Division, Inc. Display screen with graphical user interface for ablation generator
USD747491S1 (en) 2013-10-23 2016-01-12 St. Jude Medical, Cardiology Division, Inc. Ablation generator
US10034705B2 (en) 2013-10-24 2018-07-31 St. Jude Medical, Cardiology Division, Inc. High strength electrode assembly for catheter system including novel electrode
EP3060285A1 (en) 2013-10-24 2016-08-31 St. Jude Medical, Cardiology Division, Inc. Flexible catheter shaft and method of manufacture
US9999748B2 (en) 2013-10-24 2018-06-19 St. Jude Medical, Cardiology Division, Inc. Flexible catheter shaft and method of manufacture
US9949652B2 (en) 2013-10-25 2018-04-24 Ablative Solutions, Inc. Apparatus for effective ablation and nerve sensing associated with denervation
WO2015061457A1 (en) 2013-10-25 2015-04-30 Boston Scientific Scimed, Inc. Embedded thermocouple in denervation flex circuit
US10390881B2 (en) 2013-10-25 2019-08-27 Denervx LLC Cooled microwave denervation catheter with insertion feature
US10517666B2 (en) 2013-10-25 2019-12-31 Ablative Solutions, Inc. Apparatus for effective ablation and nerve sensing associated with denervation
US9931046B2 (en) 2013-10-25 2018-04-03 Ablative Solutions, Inc. Intravascular catheter with peri-vascular nerve activity sensors
US10420604B2 (en) 2013-10-28 2019-09-24 St. Jude Medical, Cardiology Division, Inc. Electrode assembly for catheter system including interlinked struts
US9861433B2 (en) 2013-11-05 2018-01-09 St. Jude Medical, Cardiology Division, Inc. Helical-shaped ablation catheter and methods of use
US20150133918A1 (en) * 2013-11-08 2015-05-14 Contego Medical, Llc Percutaneous catheter-based arterial denervation with integral emobolic filter
CN105873630B (zh) 2013-11-22 2020-01-03 隆佩瑟尔医疗公司 用于通过经血管神经刺激辅助呼吸的装置和方法
KR102171496B1 (ko) 2013-12-05 2020-10-30 알에프이엠비 홀딩스, 엘엘씨 면역 요법을 위한 보조 메커니즘으로서의 고주파 전기막 파괴(rf-emb)에 의한 암 항원의 항원표출세포로의 개선된 표출 시스템
WO2015088972A1 (en) * 2013-12-09 2015-06-18 Ryan Kendall Pierce Devices and methods for treating cardiovascular and metabolic disease
WO2015095629A1 (en) * 2013-12-20 2015-06-25 The Johns Hopkins University Method and apparatus for selective treatiment inside a body lumen
KR20160106582A (ko) * 2014-01-03 2016-09-12 엠씨10, 인크 유동 감지를 포함하는 카테터 또는 가이드 와이어 장치 및 그 용도
EP3091921B1 (en) 2014-01-06 2019-06-19 Farapulse, Inc. Apparatus for renal denervation ablation
JP6382989B2 (ja) 2014-01-06 2018-08-29 ボストン サイエンティフィック サイムド，インコーポレイテッドＢｏｓｔｏｎ Ｓｃｉｅｎｔｉｆｉｃ Ｓｃｉｍｅｄ，Ｉｎｃ． 耐引き裂き性フレキシブル回路アセンブリを備える医療デバイス
WO2015103541A1 (en) * 2014-01-06 2015-07-09 Boston Scientific Scimed, Inc. Sympathetic nerve ablation devices with an expansion-limiting member
US10166321B2 (en) 2014-01-09 2019-01-01 Angiodynamics, Inc. High-flow port and infusion needle systems
US9511228B2 (en) 2014-01-14 2016-12-06 Cyberonics, Inc. Implantable neurostimulator-implemented method for managing hypertension through renal denervation and vagus nerve stimulation
JP6484637B2 (ja) * 2014-01-17 2019-03-13 カーディアック ペースメイカーズ， インコーポレイテッド 神経連絡をブロックする枯渇ブロック
US20150202444A1 (en) 2014-01-17 2015-07-23 Cardiac Pacemakers, Inc. Systems and methods for selective stimulation of nerve fibers in carotid sinus
CA2935454A1 (en) 2014-01-21 2015-07-30 Simon Fraser University Systems and related methods for optimization of multi-electrode nerve pacing
US20150209107A1 (en) 2014-01-24 2015-07-30 Denervx LLC Cooled microwave denervation catheter configuration
EP4059563B1 (en) 2014-01-27 2023-09-27 Medtronic Ireland Manufacturing Unlimited Company Neuromodulation catheters having jacketed neuromodulation elements and related devices
US11000679B2 (en) 2014-02-04 2021-05-11 Boston Scientific Scimed, Inc. Balloon protection and rewrapping devices and related methods of use
CN106572881B (zh) 2014-02-04 2019-07-26 波士顿科学国际有限公司 热传感器在双极电极上的替代放置
US9855402B2 (en) * 2014-02-15 2018-01-02 Rex Medical, L.P. Apparatus for delivering fluid to treat renal hypertension
US10004913B2 (en) 2014-03-03 2018-06-26 The Board Of Trustees Of The Leland Stanford Junior University Methods and apparatus for power conversion and data transmission in implantable sensors, stimulators, and actuators
US10492842B2 (en) 2014-03-07 2019-12-03 Medtronic Ardian Luxembourg S.A.R.L. Monitoring and controlling internally administered cryotherapy
WO2015138225A1 (en) * 2014-03-10 2015-09-17 Mayo Foundation For Medical Education And Research Hemodynamic measurement devices and techniques
US10463424B2 (en) 2014-03-11 2019-11-05 Medtronic Ardian Luxembourg S.A.R.L. Catheters with independent radial-expansion members and associated devices, systems, and methods
US9579149B2 (en) 2014-03-13 2017-02-28 Medtronic Ardian Luxembourg S.A.R.L. Low profile catheter assemblies and associated systems and methods
US9889031B1 (en) 2014-03-25 2018-02-13 Surefire Medical, Inc. Method of gastric artery embolization
US9968740B2 (en) 2014-03-25 2018-05-15 Surefire Medical, Inc. Closed tip dynamic microvalve protection device
US9980766B1 (en) 2014-03-28 2018-05-29 Medtronic Ardian Luxembourg S.A.R.L. Methods and systems for renal neuromodulation
US10194980B1 (en) 2014-03-28 2019-02-05 Medtronic Ardian Luxembourg S.A.R.L. Methods for catheter-based renal neuromodulation
US10194979B1 (en) 2014-03-28 2019-02-05 Medtronic Ardian Luxembourg S.A.R.L. Methods for catheter-based renal neuromodulation
WO2015157667A1 (en) * 2014-04-11 2015-10-15 Jeremy Stigall Imaging and treatment device
US20170027460A1 (en) * 2015-07-29 2017-02-02 NeuroMedic, Inc. Intraluminal microneurography probe
US9999463B2 (en) 2014-04-14 2018-06-19 NeuroMedic, Inc. Monitoring nerve activity
CN106232043B (zh) 2014-04-24 2019-07-23 美敦力阿迪安卢森堡有限公司 具有编织轴的神经调节导管以及相关的系统和方法
US10398501B2 (en) 2014-04-24 2019-09-03 St. Jude Medical, Cardiology Division, Inc. Ablation systems including pulse rate detector and feedback mechanism and methods of use
US10610292B2 (en) 2014-04-25 2020-04-07 Medtronic Ardian Luxembourg S.A.R.L. Devices, systems, and methods for monitoring and/or controlling deployment of a neuromodulation element within a body lumen and related technology
US10478249B2 (en) 2014-05-07 2019-11-19 Pythagoras Medical Ltd. Controlled tissue ablation techniques
EP4238521A3 (en) 2014-05-07 2023-11-29 Farapulse, Inc. Methods and apparatus for selective tissue ablation
US10709490B2 (en) 2014-05-07 2020-07-14 Medtronic Ardian Luxembourg S.A.R.L. Catheter assemblies comprising a direct heating element for renal neuromodulation and associated systems and methods
US10434329B2 (en) 2014-05-09 2019-10-08 The Board Of Trustees Of The Leland Stanford Junior University Autofocus wireless power transfer to implantable devices in freely moving animals
AU2015259303B2 (en) 2014-05-12 2021-10-28 Arena, Christopher B. Selective modulation of intracellular effects of cells using pulsed electric fields
AU2015258956B2 (en) * 2014-05-16 2018-11-15 Medtronic Ardian Luxembourg S.A.R.L. Systems, devices, and methods for modulating renal nerve tissue
EP3145426B1 (en) 2014-05-22 2023-03-22 Aegea Medical, Inc. Apparatus for delivering vapor to the uterus
US9993290B2 (en) 2014-05-22 2018-06-12 Aegea Medical Inc. Systems and methods for performing endometrial ablation
EP3154463B1 (en) 2014-06-12 2019-03-27 Farapulse, Inc. Apparatus for rapid and selective transurethral tissue ablation
WO2015192018A1 (en) 2014-06-12 2015-12-17 Iowa Approach Inc. Method and apparatus for rapid and selective tissue ablation with cooling
WO2016007750A1 (en) * 2014-07-09 2016-01-14 Arapeen Medical, LLC Renal denervation with staged assessment
JP6342247B2 (ja) * 2014-07-18 2018-06-13 オリンパス株式会社 超音波エネルギ治療装置
US9763743B2 (en) 2014-07-25 2017-09-19 Arrinex, Inc. Apparatus and method for treating rhinitis
JP2017523849A (ja) * 2014-08-06 2017-08-24 ニューロトロニク アイ・ピー ホールディング （ジャージー） リミテッド 経血管的な神経変調療法のための電極および電極の位置決めシステム
US20160045257A1 (en) * 2014-08-14 2016-02-18 Ablative Solutions, Inc. Method for selection and treatment of hypertensive patients with renal denervation
CA2959330C (en) 2014-08-26 2022-12-13 Avent, Inc. Selective nerve fiber block method and system
WO2016033543A1 (en) 2014-08-28 2016-03-03 Medtronic Ardian Luxembourg S.A.R.L. Methods for assessing efficacy of renal neuromodulation and associated systems and devices
US20160058503A1 (en) * 2014-08-28 2016-03-03 Medtronic Ardian Luxembourg S.a.r.I. Methods for modulating renal nerve tissue and associated systems and devices
JP2017195910A (ja) * 2014-09-12 2017-11-02 テルモ株式会社 アブレーションカテーテル
EP3791817A1 (en) 2014-10-01 2021-03-17 Medtronic Ardian Luxembourg S.à.r.l. Systems for evaluating neuromodulation therapy via hemodynamic responses
EP3206613B1 (en) 2014-10-14 2019-07-03 Farapulse, Inc. Apparatus for rapid and safe pulmonary vein cardiac ablation
JP2016077801A (ja) * 2014-10-22 2016-05-16 オリンパス株式会社 電極ユニットおよび神経刺激システム
JP2017533036A (ja) 2014-10-30 2017-11-09 ニューロトロニック・インコーポレイテッドＮｅｕｒｏｔｒｏｎｉｃ， Ｉｎｃ． 様々な疾患のための処置の化学的アブレーションおよび方法
US10925579B2 (en) 2014-11-05 2021-02-23 Otsuka Medical Devices Co., Ltd. Systems and methods for real-time tracking of a target tissue using imaging before and during therapy delivery
EP3943032A1 (en) 2014-11-14 2022-01-26 Medtronic Ardian Luxembourg S.à.r.l. Catheter apparatuses for modulation of nerves in communication with the pulmonary system and associated systems
US20180326227A1 (en) * 2014-11-26 2018-11-15 Sonievie Ltd. Devices and methods for pulmonary hypertension treatment
US10271893B2 (en) 2014-12-15 2019-04-30 Medtronic Ablation Frontiers Llc Timed energy delivery
WO2016100325A1 (en) 2014-12-15 2016-06-23 Virginia Tech Intellectual Properties, Inc. Devices, systems, and methods for real-time monitoring of electrophysical effects during tissue treatment
US10667736B2 (en) 2014-12-17 2020-06-02 Medtronic Ardian Luxembourg S.A.R.L. Systems and methods for assessing sympathetic nervous system tone for neuromodulation therapy
US9974946B2 (en) * 2015-04-07 2018-05-22 NeuroTronik IP Holding (Jersey) Limited Inflatable intravascular electrode supports for neuromodulation
US10568687B2 (en) * 2015-01-16 2020-02-25 The Regents Of The University Of California Integrated intraoperative diagnosis and thermal therapy system
US10292805B2 (en) 2015-01-23 2019-05-21 Contego Medical, Llc Interventional device having an integrated embolic filter and associated methods
CA2975123A1 (en) 2015-01-30 2016-08-04 Rfemb Holdings, Llc Radio frequency electrical membrane breakdown for the treatment of high risk and recurrent prostate cancer, unresectable pancreatic cancer, tumors of the breast, melanoma or other skin malignancies, sarcoma, soft tissue tumors, ductal carcinoma, neoplasia, and intra and extra luminal abnormal tissue
US10376308B2 (en) 2015-02-05 2019-08-13 Axon Therapies, Inc. Devices and methods for treatment of heart failure by splanchnic nerve ablation
US10477354B2 (en) 2015-02-20 2019-11-12 Mc10, Inc. Automated detection and configuration of wearable devices based on on-body status, location, and/or orientation
US11077301B2 (en) 2015-02-21 2021-08-03 NeurostimOAB, Inc. Topical nerve stimulator and sensor for bladder control
KR102054003B1 (ko) * 2015-02-27 2019-12-12 주식회사 한독칼로스메디칼 카테터 및 이를 포함하는 신경차단 장치
US10820864B2 (en) * 2015-03-02 2020-11-03 Valencia Technologies Corporation Methods and systems for predicting patient responsiveness to subcutaneous neuromodulation therapy as a treatment for hypertension
WO2016160694A1 (en) 2015-03-27 2016-10-06 Shifamed Holdings, Llc Steerable medical devices, systems, and methods of use
US20160287839A1 (en) 2015-03-31 2016-10-06 Surefire Medical, Inc. Apparatus and Method for Infusing an Immunotherapy Agent to a Solid Tumor for Treatment
EP3319689A4 (en) * 2015-04-13 2019-05-08 NeuroTronik IP Holding (Jersey) Limited SYSTEMS AND METHODS FOR GENERATING THERAPEUTIC ELECTRIC FIELDS FOR CAPTURING TARGETS OF THE NERVOUS SYSTEM
WO2016168381A1 (en) 2015-04-13 2016-10-20 Bazoberry Carlos Fernando Radiofrequency denervation needle and method
CA2982823A1 (en) 2015-04-24 2016-10-27 Shifamed Holdings, Llc Steerable medical devices, systems, and methods of use
US10383685B2 (en) 2015-05-07 2019-08-20 Pythagoras Medical Ltd. Techniques for use with nerve tissue
CN107835705B (zh) * 2015-05-12 2022-05-13 爱尔兰国立高威大学 用于治疗性鼻神经调节的装置及相关的方法和系统
US20160338769A1 (en) * 2015-05-18 2016-11-24 Biosense Webster (Israel) Ltd. Catheter with anchoring balloon assembly
AU2016275556A1 (en) * 2015-06-10 2017-12-14 Cathrx Ltd Double shape catheter
US10799287B2 (en) 2015-07-07 2020-10-13 Boston Scientific Scimed, Inc. Medical device having extenable members
JP6998295B2 (ja) * 2015-07-21 2022-01-18 コーニンクレッカ フィリップス エヌ ヴェ 腎神経を刺激するシステム
US10660691B2 (en) 2015-10-07 2020-05-26 Angiodynamics, Inc. Multiple use subassembly with integrated fluid delivery system for use with single or dual-lumen peristaltic tubing
US10207110B1 (en) 2015-10-13 2019-02-19 Axon Therapies, Inc. Devices and methods for treatment of heart failure via electrical modulation of a splanchnic nerve
CN108366715A (zh) 2015-11-09 2018-08-03 施菲姆德控股有限责任公司 用于医疗装置的转向组件和使用方法
EP3376936B1 (en) 2015-11-16 2024-01-03 Boston Scientific Scimed, Inc. Energy delivery devices
US10675085B2 (en) 2015-11-23 2020-06-09 Boston Scientific Scimed, Inc. Devices and methods for enhanced denervation procedures
US20170150922A1 (en) 2015-11-30 2017-06-01 Palo Alto Investors Methods of Enhancing Homeostatic Capacity in a Subject by Increasing Homeostatic System Component Responsiveness, and Devices for Use in Practicing the Same
SG11201804191TA (en) * 2015-12-01 2018-06-28 Symap Medical Suzhou Ltd System and method for mapping functional nerves innervating wall of arteries,3-d mapping and catheters for same
US20170188308A1 (en) * 2015-12-23 2017-06-29 Intel Corporation Extending an operational lifetime of an internet of things (IOT) device
US10660702B2 (en) 2016-01-05 2020-05-26 Farapulse, Inc. Systems, devices, and methods for focal ablation
EP3399933B1 (en) * 2016-01-05 2021-09-01 Farapulse, Inc. Systems for delivery of pulsed electric field ablative energy to endocardial tissue
US10130423B1 (en) 2017-07-06 2018-11-20 Farapulse, Inc. Systems, devices, and methods for focal ablation
US10172673B2 (en) 2016-01-05 2019-01-08 Farapulse, Inc. Systems devices, and methods for delivery of pulsed electric field ablative energy to endocardial tissue
US20170189097A1 (en) 2016-01-05 2017-07-06 Iowa Approach Inc. Systems, apparatuses and methods for delivery of ablative energy to tissue
US11006887B2 (en) 2016-01-14 2021-05-18 Biosense Webster (Israel) Ltd. Region of interest focal source detection using comparisons of R-S wave magnitudes and LATs of RS complexes
US10624554B2 (en) * 2016-01-14 2020-04-21 Biosense Webster (Israel) Ltd. Non-overlapping loop-type or spline-type catheter to determine activation source direction and activation source type
US11612426B2 (en) 2016-01-15 2023-03-28 Immunsys, Inc. Immunologic treatment of cancer
WO2017123954A1 (en) * 2016-01-15 2017-07-20 University Of Cincinnati Advanced electroporation devices and methods for analyte access in biofluids
US11602260B2 (en) 2016-02-11 2023-03-14 Arrinex, Inc. Method and device for image guided post-nasal nerve ablation
US11331037B2 (en) 2016-02-19 2022-05-17 Aegea Medical Inc. Methods and apparatus for determining the integrity of a bodily cavity
US10277386B2 (en) 2016-02-22 2019-04-30 Mc10, Inc. System, devices, and method for on-body data and power transmission
EP3216488B1 (en) * 2016-03-10 2023-07-12 BIOTRONIK SE & Co. KG Delivery system for implantable stimulation devices and corresponding catheters
WO2017173089A1 (en) * 2016-03-31 2017-10-05 Memorial Sloan Kettering Cancer Center Systems and methods for enhancing delivery of diagnostic and/or therapeutic compositions in vivo using electric pulses
DE102016106478A1 (de) 2016-04-08 2017-10-12 Biotronik Ag Vorrichtung zur Energieabgabe und/oder Messung von elektrischer Aktivität
WO2017189890A1 (en) * 2016-04-27 2017-11-02 Neux Technologies, Inc. Electrotherapeutic treatment
US10736692B2 (en) 2016-04-28 2020-08-11 Medtronic Ardian Luxembourg S.A.R.L. Neuromodulation and associated systems and methods for the treatment of cancer
EP4349396A2 (en) 2016-05-13 2024-04-10 Pacira CryoTech, Inc. Systems for locating and treating with cold therapy
WO2017199240A2 (en) 2016-05-18 2017-11-23 Pythagoras Medical Ltd. Helical catheter
US11331140B2 (en) 2016-05-19 2022-05-17 Aqua Heart, Inc. Heated vapor ablation systems and methods for treating cardiac conditions
CN109414284B (zh) * 2016-05-20 2021-08-10 美国宾得公司 具有可旋转并且可平移的导管的低温消融系统
CN107440788A (zh) * 2016-06-01 2017-12-08 四川锦江电子科技有限公司 一种具有极间放电功能的消融导管及消融装置
US10524859B2 (en) 2016-06-07 2020-01-07 Metavention, Inc. Therapeutic tissue modulation devices and methods
CN109600988B (zh) 2016-06-15 2021-08-31 阿里内克斯股份有限公司 用于治疗鼻腔外侧表面的装置和方法
EP3471631A4 (en) 2016-06-16 2020-03-04 Farapulse, Inc. GUIDE WIRE DISTRIBUTION SYSTEMS, APPARATUSES AND METHODS
WO2017223264A1 (en) 2016-06-23 2017-12-28 St. Jude Medical, Cardiology Division, Inc. Catheter system and electrode assembly for intraprocedural evaluation of renal denervation
AU2017289267B2 (en) 2016-06-27 2021-08-12 Galvanize Therapeutics, Inc. Generator and a catheter with an electrode and a method for treating a lung passageway
EP3481317A4 (en) * 2016-07-11 2020-03-04 Retrovascular, Inc. BIPOLAR TISSUE ABLATION DEVICE AND METHOD FOR USE THEREOF
EP3484577A4 (en) 2016-07-18 2020-03-25 Nalu Medical, Inc. METHODS AND SYSTEMS FOR THE TREATMENT OF PELVIC DISORDERS AND PAINFUL CONDITIONS
CN109843160B (zh) 2016-07-29 2022-04-15 阿克松疗法公司 通过脏神经消融术治疗心脏衰竭的装置、系统和方法
US10447347B2 (en) 2016-08-12 2019-10-15 Mc10, Inc. Wireless charger and high speed data off-loader
DE102016116871A1 (de) * 2016-09-08 2018-03-08 Phenox Gmbh Vorrichtung und Verfahren zur Vorbeugung und Behandlung eines Vasospasmus
US10780250B1 (en) 2016-09-19 2020-09-22 Surefire Medical, Inc. System and method for selective pressure-controlled therapeutic delivery
US11400263B1 (en) 2016-09-19 2022-08-02 Trisalus Life Sciences, Inc. System and method for selective pressure-controlled therapeutic delivery
US11253312B2 (en) 2016-10-17 2022-02-22 Arrinex, Inc. Integrated nasal nerve detector ablation-apparatus, nasal nerve locator, and methods of use
US10537709B2 (en) 2016-10-18 2020-01-21 Boston Scientific Scimed, Inc. Guide extension catheter
JP2019532741A (ja) * 2016-10-20 2019-11-14 レトロバスキュラー インコーポレイテッド 向上した組成物送達のための方法及び装置
US10231784B2 (en) 2016-10-28 2019-03-19 Medtronic Ardian Luxembourg S.A.R.L. Methods and systems for optimizing perivascular neuromodulation therapy using computational fluid dynamics
JP7278948B2 (ja) * 2016-10-31 2023-05-22 ゼネラル・エレクトリック・カンパニイ 神経調節のための技術
US11382513B2 (en) 2016-11-08 2022-07-12 Palo Alto Investors Methods and compositions for treating a condition in a subject
WO2018089795A1 (en) 2016-11-10 2018-05-17 Qoravita LLC System and method for applying a low frequency magnetic field to biological tissues
CN110191674B (zh) 2016-11-11 2023-04-07 爱尔兰国立高威大学 用于专门化，监测，和/或评估治疗性鼻神经调节的装置，系统，和方法
US10905492B2 (en) 2016-11-17 2021-02-02 Angiodynamics, Inc. Techniques for irreversible electroporation using a single-pole tine-style internal device communicating with an external surface electrode
WO2018115141A1 (en) * 2016-12-20 2018-06-28 Galvani Bioelectronics Limited Neuromodulation device
JP2018102650A (ja) * 2016-12-27 2018-07-05 京セラ株式会社 腎神経用超音波カテーテル
JP2020503918A (ja) * 2017-01-05 2020-02-06 マグネト スロムベクトミィ ソリューションズ リミテッド 血栓摘出術用装置
US10646713B2 (en) 2017-02-22 2020-05-12 Medtronic Ardian Luxembourg S.A.R.L. Systems, devices, and associated methods for treating patients via renal neuromodulation to reduce a risk of developing cognitive impairment
WO2018156953A1 (en) 2017-02-24 2018-08-30 Nalu Medical, Inc. Apparatus with sequentially implanted stimulators
US20200094080A1 (en) 2017-03-20 2020-03-26 Sonivie Ltd. Method for treating heart failure by improving ejection fraction of a patient
US10588636B2 (en) 2017-03-20 2020-03-17 Surefire Medical, Inc. Dynamic reconfigurable microvalve protection device
CN106901831A (zh) * 2017-03-23 2017-06-30 深圳市惠泰医疗器械有限公司 肾动脉刺激消融电极导管
US20200188696A1 (en) * 2017-04-03 2020-06-18 Mdsg Innovation Ltd. Apparatus and method for treating kidneys
US20190091475A1 (en) * 2017-04-16 2019-03-28 Jose Carlos Pachon-Mateos Extracardiac autonomic nerve stimulation
US9987081B1 (en) 2017-04-27 2018-06-05 Iowa Approach, Inc. Systems, devices, and methods for signal generation
US10617867B2 (en) * 2017-04-28 2020-04-14 Farapulse, Inc. Systems, devices, and methods for delivery of pulsed electric field ablative energy to esophageal tissue
JP7300999B2 (ja) 2017-04-28 2023-06-30 アリネックス， インコーポレイテッド 鼻炎の治療において血管を位置特定するためのシステムおよび方法
US10293164B2 (en) 2017-05-26 2019-05-21 Lungpacer Medical Inc. Apparatus and methods for assisted breathing by transvascular nerve stimulation
EP4115942A1 (en) 2017-06-30 2023-01-11 Lungpacer Medical Inc. System for prevention, moderation, and/or treatment of cognitive injury
US11116564B2 (en) 2017-07-05 2021-09-14 Medtronic Ardian Luxembourg S.A.R.L. Methods for treating anxiety disorders in patients via renal neuromodulation
US10945788B2 (en) 2017-07-05 2021-03-16 Medtronic Ardian Luxembourg S.A.R.L. Methods for treating depression in patients via renal neuromodulation
US11160982B2 (en) 2017-07-05 2021-11-02 Medtronic Ardian Luxembourg S.A.R.L. Methods for treating post-traumatic stress disorder in patients via renal neuromodulation
JP6377219B2 (ja) * 2017-07-14 2018-08-22 株式会社リバーセイコー 医療用アブレーションカテーテルの製造方法
US10195429B1 (en) 2017-08-02 2019-02-05 Lungpacer Medical Inc. Systems and methods for intravascular catheter positioning and/or nerve stimulation
US10940308B2 (en) 2017-08-04 2021-03-09 Lungpacer Medical Inc. Systems and methods for trans-esophageal sympathetic ganglion recruitment
CN109464186B (zh) * 2017-09-08 2023-12-22 泽丹医疗股份有限公司 治疗肺部肿瘤的装置和方法
WO2019051274A2 (en) * 2017-09-08 2019-03-14 Zidan Medical, Inc. DEVICES FOR THE TREATMENT OF BRONCHOPULMONARY TUMORS
EP3681391A1 (en) * 2017-09-12 2020-07-22 Farapulse, Inc. Systems, apparatuses, and methods for ventricular focal ablation
US20190117970A1 (en) * 2017-10-23 2019-04-25 Cardiac Pacemakers, Inc. Electric field shaping leads for treatment of cancer
US11338135B2 (en) 2017-10-23 2022-05-24 Cardiac Pacemakers, Inc. Medical devices for cancer therapy with electric field shaping elements
CN111479610A (zh) 2017-10-23 2020-07-31 梅约医学教育与研究基金会 用于电穿孔的系统和方法
US20190117971A1 (en) * 2017-10-23 2019-04-25 Cardiac Pacemakers, Inc. Volume-filling leads for treatment of cancer with electric fields
WO2019094365A1 (en) 2017-11-07 2019-05-16 Neurostim Oab, Inc. Non-invasive nerve activator with adaptive circuit
US11134998B2 (en) 2017-11-15 2021-10-05 Pacira Cryotech, Inc. Integrated cold therapy and electrical stimulation systems for locating and treating nerves and associated methods
US11304749B2 (en) 2017-11-17 2022-04-19 Medtronic Ardian Luxembourg S.A.R.L. Systems, devices, and associated methods for neuromodulation with enhanced nerve targeting
AU2018373389A1 (en) 2017-11-27 2020-07-16 Thayne LARSON An apparatus and a method for the treatment of a prostatic disease
US11607537B2 (en) 2017-12-05 2023-03-21 Virginia Tech Intellectual Properties, Inc. Method for treating neurological disorders, including tumors, with electroporation
WO2019118976A1 (en) 2017-12-17 2019-06-20 Axon Therapies, Inc. Methods and devices for endovascular ablation of a splanchnic nerve
US11116561B2 (en) 2018-01-24 2021-09-14 Medtronic Ardian Luxembourg S.A.R.L. Devices, agents, and associated methods for selective modulation of renal nerves
US10786306B2 (en) 2018-01-24 2020-09-29 Medtronic Ardian Luxembourg S.A.R.L. Denervation therapy
US10959669B2 (en) 2018-01-24 2021-03-30 Medtronic Ardian Luxembourg S.A.R.L. Systems and methods for assessing the efficacy of neuromodulation therapy
US11478298B2 (en) 2018-01-24 2022-10-25 Medtronic Ardian Luxembourg S.A.R.L. Controlled irrigation for neuromodulation systems and associated methods
US11717343B2 (en) 2018-01-24 2023-08-08 Medtronic Ireland Manufacturing Unlimited Company Systems, devices, and associated methods for neuromodulation in heterogeneous tissue environments
US11253189B2 (en) 2018-01-24 2022-02-22 Medtronic Ardian Luxembourg S.A.R.L. Systems, devices, and methods for evaluating neuromodulation therapy via detection of magnetic fields
US11751939B2 (en) 2018-01-26 2023-09-12 Axon Therapies, Inc. Methods and devices for endovascular ablation of a splanchnic nerve
JP6905230B2 (ja) * 2018-01-31 2021-07-21 国立大学法人広島大学 塞栓術装置
WO2019168949A1 (en) 2018-02-28 2019-09-06 Prostacare Pty Ltd System for managing high impedance changes in a non-thermal ablation system for bph
US11311329B2 (en) 2018-03-13 2022-04-26 Virginia Tech Intellectual Properties, Inc. Treatment planning for immunotherapy based treatments using non-thermal ablation techniques
US11925405B2 (en) 2018-03-13 2024-03-12 Virginia Tech Intellectual Properties, Inc. Treatment planning system for immunotherapy enhancement via non-thermal ablation
EP3765146A2 (en) * 2018-03-15 2021-01-20 Avent, Inc. System and method to percutaneously block painful sensations
CN112087980B (zh) 2018-05-07 2023-01-10 波士顿科学医学有限公司 用于将消融能量递送到组织的系统、设备和方法
CN112118798A (zh) 2018-05-07 2020-12-22 法拉普尔赛股份有限公司 用于过滤由脉冲电场消融诱导的高压噪声的系统、设备和方法
CN112087978B (zh) 2018-05-07 2023-01-17 波士顿科学医学有限公司 心外膜消融导管
JP2021525598A (ja) 2018-06-01 2021-09-27 サンタ アナ テック エルエルシーＳａｎｔａ Ａｎｎａ Ｔｅｃｈ Ｌｌｃ 多段階蒸気ベースのアブレーション処理方法並びに蒸気発生及びデリバリー・システム
US11413084B2 (en) 2018-07-03 2022-08-16 Medtronic Ardian Luxembourg S.A.R.L. Methods for treating eating disorders in patients via renal neuromodulation
US10849685B2 (en) 2018-07-18 2020-12-01 Ablative Solutions, Inc. Peri-vascular tissue access catheter with locking handle
US11553960B2 (en) 2018-07-31 2023-01-17 Medtronic Ardian Luxembourg S.A.R.L. Methods for treating patients with catheter-based renal neuromodulation
US11850398B2 (en) 2018-08-01 2023-12-26 Trisalus Life Sciences, Inc. Systems and methods for pressure-facilitated therapeutic agent delivery
US11633120B2 (en) 2018-09-04 2023-04-25 Medtronic Ardian Luxembourg S.A.R.L. Systems and methods for assessing efficacy of renal neuromodulation therapy
WO2020061359A1 (en) 2018-09-20 2020-03-26 Farapulse, Inc. Systems, apparatuses, and methods for delivery of pulsed electric field ablative energy to endocardial tissue
CN113164127A (zh) 2018-10-06 2021-07-23 苏州信迈医疗器械有限公司 用于标测支配动脉壁功能性神经的系统和方法以及可实现相同功能的3d标测法和导管
US11338117B2 (en) 2018-10-08 2022-05-24 Trisalus Life Sciences, Inc. Implantable dual pathway therapeutic agent delivery port
WO2020081153A1 (en) * 2018-10-17 2020-04-23 University Of Florida Research Foundation Controlling esophageal temperature during cardiac ablation
EP3877043A4 (en) 2018-11-08 2022-08-24 Lungpacer Medical Inc. STIMULATION SYSTEM AND ASSOCIATED USER INTERFACES
JP7404622B2 (ja) * 2018-11-30 2023-12-26 ニプロ株式会社 測定用カテーテル
US11666378B2 (en) 2018-12-11 2023-06-06 Neurent Medical Limited Systems and methods for therapeutic nasal neuromodulation
CN109394211B (zh) * 2018-12-18 2021-08-06 新乡医学院 一种在体电生理记录金属电极的制备方法
US20220126087A1 (en) * 2019-03-18 2022-04-28 Rambam Medtech Ltd Alternating charge to inhibit sorption to surfaces exposed to biological materials
CN113766949A (zh) 2019-04-22 2021-12-07 波士顿科学国际有限公司 用于施用电刺激以治疗癌症的系统
US11691006B2 (en) 2019-04-22 2023-07-04 Boston Scientific Scimed, Inc. Electrical stimulation devices for cancer treatment
US11607542B2 (en) 2019-04-23 2023-03-21 Boston Scientific Scimed, Inc. Electrical stimulation for cancer treatment with internal and external electrodes
US11850422B2 (en) 2019-04-23 2023-12-26 Boston Scientific Scimed, Inc. Electrodes for electrical stimulation to treat cancer
US11712561B2 (en) 2019-04-23 2023-08-01 Boston Scientific Scimed, Inc. Electrical stimulation with thermal treatment or thermal monitoring
WO2020232333A1 (en) 2019-05-16 2020-11-19 Lungpacer Medical Inc. Systems and methods for sensing and stimulation
EP3983057A4 (en) 2019-06-12 2023-07-12 Lungpacer Medical Inc. CIRCUIT FOR MEDICAL STIMULATION SYSTEMS
WO2020257763A1 (en) 2019-06-20 2020-12-24 Axon Therapies, Inc. Methods and devices for endovascular ablation of a splanchnic nerve
EP3990100A4 (en) 2019-06-26 2023-07-19 Neurostim Technologies LLC NON-INVASIVE NERVE ACTIVATOR WITH ADAPTIVE CIRCUIT
US10625080B1 (en) 2019-09-17 2020-04-21 Farapulse, Inc. Systems, apparatuses, and methods for detecting ectopic electrocardiogram signals during pulsed electric field ablation
US10967052B1 (en) 2019-10-18 2021-04-06 Penland Foundation Treatment of dyslexia using botulinum toxin
US11738071B2 (en) 2021-07-12 2023-08-29 Penland Foundation Treatment of acute and chronic kidney disease
US10960061B1 (en) 2019-10-18 2021-03-30 Penland Foundation Treatment of amyotrophic lateral sclerosis using botulinum toxin
US11925677B2 (en) 2021-07-12 2024-03-12 Penland Foundation Treatment of diabetes and chronic pancreatitis using botulinum toxin
US11291500B2 (en) * 2019-11-05 2022-04-05 Sirona Medical Technologies, Inc. Multi-modal catheter for improved electrical mapping and ablation
US11497541B2 (en) 2019-11-20 2022-11-15 Boston Scientific Scimed, Inc. Systems, apparatuses, and methods for protecting electronic components from high power noise induced by high voltage pulses
US11065047B2 (en) 2019-11-20 2021-07-20 Farapulse, Inc. Systems, apparatuses, and methods for protecting electronic components from high power noise induced by high voltage pulses
US10842572B1 (en) 2019-11-25 2020-11-24 Farapulse, Inc. Methods, systems, and apparatuses for tracking ablation devices and generating lesion lines
JP2023506713A (ja) 2019-12-16 2023-02-20 ニューロスティム テクノロジーズ エルエルシー 昇圧電荷送達を用いた非侵襲性神経アクティベータ
JP2023510597A (ja) 2020-01-17 2023-03-14 アクソン セラピーズ，インク． 内臓神経の血管内アブレーションの方法及びデバイス
CN115515674A (zh) 2020-02-24 2022-12-23 波士顿科学国际有限公司 用于治疗胰腺癌的系统和方法
JP7428816B2 (ja) 2020-02-28 2024-02-06 セント・ジュード・メディカル，カーディオロジー・ディヴィジョン，インコーポレイテッド 拡張可能な隔離部材を含む電極アセンブリ
WO2021173215A1 (en) * 2020-02-28 2021-09-02 St. Jude Medical, Cardiology Division, Inc. Electrode assembly including expandable isolation member
WO2021205229A1 (en) 2020-04-09 2021-10-14 Neurent Medical Limited Systems and methods for improving sleep with therapeutic nasal treatment
WO2021205230A1 (en) 2020-04-09 2021-10-14 Neurent Medical Limited Systems and methods for therapeutic nasal treatment
US20220022954A1 (en) * 2020-07-24 2022-01-27 Boston Scientific Scimed, Inc. Electroporation catheter having tissue-contactless electrodes
WO2022182756A1 (en) * 2021-02-23 2022-09-01 Inspire Medical Systems, Inc. Integrating stimulation therapy, patient management, and external patient monitoring
ES2954101T3 (es) 2021-03-09 2023-11-20 Circle Safe Estimulación del nervio frénico
JP2021090892A (ja) * 2021-03-22 2021-06-17 京セラ株式会社 腎神経用超音波カテーテル
US20240108406A1 (en) * 2021-04-05 2024-04-04 Nu Eyne Co.,Ltd Renal denervation catheter
CA3215962A1 (en) * 2021-04-26 2022-11-03 Roman Turovskiy Circumferential ablation devices and methods
CN113633282A (zh) * 2021-07-19 2021-11-12 上海安通医疗科技有限公司 一种肾动脉交感神经活性测量系统
US20230026265A1 (en) * 2021-07-22 2023-01-26 Boston Scientific Scimed, Inc. Hybrid electroporation ablation catheter
CN113633283A (zh) * 2021-07-29 2021-11-12 上海安通医疗科技有限公司 一种介入式肾动脉交感神经活性检测系统
US20230101016A1 (en) 2021-09-27 2023-03-30 Medtronic, Inc. Intra-body electrode with a poly(3,4-ethylenedioxythiophene)-based coating
CN113768616B (zh) * 2021-10-20 2023-02-24 四川锦江电子医疗器械科技股份有限公司 一种用于心脏消融的综合系统
WO2023066799A1 (en) * 2021-10-22 2023-04-27 Biotronik Se & Co. Kg Intravascular implant for stimulating of blood pressure
US20230225791A1 (en) * 2022-01-18 2023-07-20 Koninklijke Philips N.V. Guided renal denervation using nerve stimulation with blood pressure and renal blood velocity measurements, and associated systems, device, and methods
WO2023167343A1 (ko) * 2022-03-02 2023-09-07 박을준 신장 신경 절제결과 평가 방법 및 장치

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5944710A (en) * 1996-06-24 1999-08-31 Genetronics, Inc. Electroporation-mediated intravascular delivery
US6219577B1 (en) * 1998-04-14 2001-04-17 Global Vascular Concepts, Inc. Iontophoresis, electroporation and combination catheters for local drug delivery to arteries and other body tissues

Family Cites Families (1270)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1026407A (en) 1908-12-21 1912-05-14 Steel Shoe Company Footwear.
US1017857A (en) 1910-03-25 1912-02-20 Amphion Piano Player Company Valve for pneumatic actions.
US2130758A (en) 1935-06-01 1938-09-20 E J Rose Mfg Company Of Califo Electrode for diathermy treatment and the like
US2276995A (en) 1938-01-22 1942-03-17 A J Ginsberg Electrotherapy
US2276996A (en) 1940-11-30 1942-03-17 A J Ginsberg Non-radio-interfering therapeutic apparatus
US2389453A (en) 1943-04-15 1945-11-20 Sun Oil Co Amides
US3181535A (en) 1957-10-04 1965-05-04 Diapulse Mfg Corp Of America Athermapeutic apparatus
US3043310A (en) 1959-04-24 1962-07-10 Diapulse Mfg Corp Of America Treatment head for athermapeutic apparatus
US3127895A (en) 1962-07-02 1964-04-07 Dynapower System Corp Therapeutic pulse generation and control circuit
US3270746A (en) 1963-08-26 1966-09-06 Dynapower Systems Corp High-performance electrotherapeutic treatment head
US3329149A (en) 1964-10-28 1967-07-04 Dynapower Systems Corp Of Cali Supporting arm for electrotherapeutic treatment head
US3563246A (en) 1967-04-24 1971-02-16 Intelectron Corp Method and apparatus for improving neural performance in human subjects by electrotherapy
US3522811A (en) 1969-02-13 1970-08-04 Medtronic Inc Implantable nerve stimulator and method of use
SE346468B (zh) 1969-02-24 1972-07-10 Lkb Medical Ab
JPS499882Y1 (zh) 1969-09-11 1974-03-08
US3670737A (en) 1970-07-02 1972-06-20 Diapulse Corp Of America Ultra-short wave athermapeutic apparatus
US3760812A (en) 1971-03-19 1973-09-25 Univ Minnesota Implantable spiral wound stimulation electrodes
US3774620A (en) 1971-06-14 1973-11-27 Nemectron Gmbh Electromedicinal apparatus for interference current therapy
US3895639A (en) 1971-09-07 1975-07-22 Rodler Ing Hans Apparatus for producing an interference signal at a selected location
US3800802A (en) 1972-01-07 1974-04-02 Int Medical Electronics Ltd Short-wave therapy apparatus
US3752162A (en) 1972-04-10 1973-08-14 Dow Corning Artificial cutaneous stoma
US3794022A (en) 1972-06-30 1974-02-26 E Nawracaj Dual oscillator, variable pulse duration electrotherapeutic device
US3803463A (en) 1972-07-10 1974-04-09 J Cover Weapon for immobilization and capture
GB1456509A (en) 1973-02-20 1976-11-24 Dow Corning Ltd Bonding silicone rubber to wood and masonry
US3897789A (en) 1973-09-13 1975-08-05 Stanley J Blanchard Acupuncture apparatus
US3894532A (en) 1974-01-17 1975-07-15 Acupulse Inc Instruments for transcutaneous and subcutaneous investigation and treatment
US3911930A (en) 1974-03-01 1975-10-14 Stimulation Tech Method and structure of preventing and treating ileus, and reducing acute pain by electrical pulse stimulation
US4011861A (en) 1974-04-03 1977-03-15 Case Western Reserve University Implantable electric terminal for organic tissue
US4055190A (en) 1974-12-19 1977-10-25 Michio Tany Electrical therapeutic apparatus
US3952751A (en) 1975-01-08 1976-04-27 W. Denis Kendall High-performance electrotherapeutic apparatus
US4026300A (en) 1975-03-14 1977-05-31 Liberty Mutual Method and apparatus for interfacing to nerves
US3987790A (en) 1975-10-01 1976-10-26 Alza Corporation Osmotically driven fluid dispenser
US4266532A (en) 1976-11-17 1981-05-12 Electro-Biology, Inc. Modification of the growth, repair and maintenance behavior of living tissues and cells by a specific and selective change in electrical environment
US4315503A (en) 1976-11-17 1982-02-16 Electro-Biology, Inc. Modification of the growth, repair and maintenance behavior of living tissues and cells by a specific and selective change in electrical environment
US4105017A (en) 1976-11-17 1978-08-08 Electro-Biology, Inc. Modification of the growth repair and maintenance behavior of living tissue and cells by a specific and selective change in electrical environment
US4071033A (en) 1976-12-20 1978-01-31 Nawracaj Edward P Electrotherapeutic device with modulated dual signals
US4141365A (en) 1977-02-24 1979-02-27 The Johns Hopkins University Epidural lead electrode and insertion needle
US4154246A (en) 1977-07-25 1979-05-15 Leveen Harry H Field intensification in radio frequency thermotherapy
US4169464A (en) 1977-12-16 1979-10-02 Cordis Corporation Catheter for selective catheterization of aortic branches
US4360019A (en) 1979-02-28 1982-11-23 Andros Incorporated Implantable infusion device
US4305115A (en) 1979-03-14 1981-12-08 Harry H. Leveen Electrostatic shield
JPS55137141A (en) 1979-04-13 1980-10-25 Teijin Ltd Porous polyamide membrane and production thereof
US4332259A (en) 1979-09-19 1982-06-01 Mccorkle Jr Charles E Intravenous channel cardiac electrode and lead assembly and method
US4692147A (en) 1980-04-02 1987-09-08 Medtronic, Inc. Drug administration device
US4405305A (en) 1980-10-27 1983-09-20 University Of Utah Research Foundation Subcutaneous peritoneal injection catheter
US4379462A (en) 1980-10-29 1983-04-12 Neuromed, Inc. Multi-electrode catheter assembly for spinal cord stimulation
CS226514B1 (en) 1981-01-28 1984-04-16 Petr Ing Csc Slovak Apparatus for stimulating live tissues
US4419819A (en) 1982-01-29 1983-12-13 Medtronic, Inc. Method of making biomedical lead with lobed lead anchor
US4454883A (en) 1982-02-16 1984-06-19 Therafield Holdings Limited Electrotherapeutic apparatus
US4617939A (en) 1982-04-30 1986-10-21 The University Of Sheffield Tomography
US4530840A (en) 1982-07-29 1985-07-23 The Stolle Research And Development Corporation Injectable, long-acting microparticle formulation for the delivery of anti-inflammatory agents
US4467808A (en) 1982-09-17 1984-08-28 Biolectron, Inc. Method for preventing and treating osteoporosis in a living body by using electrical stimulation non-invasively
US4487603A (en) 1982-11-26 1984-12-11 Cordis Corporation Implantable microinfusion pump system
DE3300668A1 (de) 1983-01-11 1984-07-12 Siemens AG, 1000 Berlin und 8000 München Elektrode fuer medizinische anwendungen
FR2541902B1 (fr) 1983-03-04 1986-02-07 Cofrem International Sa Appareil therapeutique athermique
EP0132344A3 (en) 1983-07-20 1986-01-22 Purdue Research Foundation Improved catheter based cardiac output sensor
US4531943A (en) 1983-08-08 1985-07-30 Angiomedics Corporation Catheter with soft deformable tip
DE3483160D1 (de) 1983-09-14 1990-10-11 Jacob Zabara Neurocybernetische prothese.
JPS60100516A (ja) 1983-11-04 1985-06-04 Takeda Chem Ind Ltd 徐放型マイクロカプセルの製造法
US4816016A (en) 1984-03-16 1989-03-28 Pudenz-Schulte Medical Research Corp. Subcutaneous infusion reservoir and pump system
US4587975A (en) 1984-07-02 1986-05-13 Cardiac Pacemakers, Inc. Dimension sensitive angioplasty catheter
US4674482A (en) 1984-09-12 1987-06-23 Irt, Inc. Pulse electro-magnetic field therapy device with auto bias circuit
US4608985A (en) 1984-10-11 1986-09-02 Case Western Reserve University Antidromic pulse generating wave form for collision blocking
US4649936A (en) 1984-10-11 1987-03-17 Case Western Reserve University Asymmetric single electrode cuff for generation of unidirectionally propagating action potentials for collision blocking
US4602624A (en) 1984-10-11 1986-07-29 Case Western Reserve University Implantable cuff, method of manufacture, and method of installation
JPS61116595A (ja) 1984-11-12 1986-06-04 Riso Kagaku Corp 感熱孔版印刷用原紙
JPS61151245A (ja) 1984-12-25 1986-07-09 Sumitomo Electric Ind Ltd 多孔性薄膜材料の表面処理方法
JPS61176324A (ja) * 1985-01-31 1986-08-08 フクダ電子株式会社 電極装置
US4706671A (en) 1985-05-02 1987-11-17 Weinrib Harry P Catheter with coiled tip
US4660571A (en) 1985-07-18 1987-04-28 Cordis Corporation Percutaneous lead having radially adjustable electrode
US5449343A (en) 1985-07-30 1995-09-12 Advanced Cardiovascular Systems, Inc. Steerable dilatation catheter
FR2592791A1 (fr) 1986-01-14 1987-07-17 Ire Celltarg Sa Composition pharmaceutique, contenant un anesthesique local et/ou un analgesique central encapsule dans des liposomes
US4865845A (en) 1986-03-21 1989-09-12 Alza Corporation Release rate adjustment of osmotic or diffusional delivery devices
JPS62181225U (zh) 1986-05-07 1987-11-17
US4709698A (en) 1986-05-14 1987-12-01 Thomas J. Fogarty Heatable dilation catheter
US5014699A (en) 1986-05-23 1991-05-14 Trustees Of The University Of Pennsylvania Electromagnetic method and apparatus for healing living tissue
US4998532A (en) 1986-05-23 1991-03-12 Lti Biomedical, Inc. Portable electro-therapy system
US4715852A (en) 1986-07-21 1987-12-29 Eaton Corporation Implanted medication infusion device
US4774967A (en) 1986-09-09 1988-10-04 American Biointerface Corporation Method and apparatus for mammalian nerve regeneration
US4796643A (en) 1986-09-30 1989-01-10 Telectronics N.V. Medical electrode leads
US5231995A (en) 1986-11-14 1993-08-03 Desai Jawahar M Method for catheter mapping and ablation
US5365926A (en) 1986-11-14 1994-11-22 Desai Jawahar M Catheter for mapping and ablation and method therefor
US4834724A (en) 1987-04-06 1989-05-30 Geiss Alan C Device for aspirating fluids from a body cavity or hollow organ
US4791931A (en) 1987-08-13 1988-12-20 Pacesetter Infusion, Ltd. Demand pacemaker using an artificial baroreceptor reflex
US4781682A (en) 1987-08-13 1988-11-01 Patel Piyush V Catheter having support flaps and method of inserting catheter
US5154705A (en) 1987-09-30 1992-10-13 Lake Region Manufacturing Co., Inc. Hollow lumen cable apparatus
US4819661A (en) 1987-10-26 1989-04-11 Cardiac Pacemakers, Inc. Positive fixation cardiac electrode with drug elution capabilities
US4860769A (en) 1987-11-12 1989-08-29 Thomas J. Fogarty Implantable defibrillation electrode
US4852573A (en) 1987-12-04 1989-08-01 Kennedy Philip R Implantable neural electrode
US4957118A (en) 1988-01-15 1990-09-18 Jay Erlebacher Electrode lead
DE68925030T2 (de) 1988-01-21 1996-07-25 Massachusetts Inst Technology Molekültransport durch gewebe mit der verwendung von elektroporation.
US5389069A (en) 1988-01-21 1995-02-14 Massachusetts Institute Of Technology Method and apparatus for in vivo electroporation of remote cells and tissue
US4926875A (en) * 1988-01-25 1990-05-22 Baylor College Of Medicine Implantable and extractable biological sensor probe
US4890623A (en) 1988-03-14 1990-01-02 C. R. Bard, Inc. Biopotential sensing device and method for making
CA1319174C (en) 1988-04-21 1993-06-15 Lawrence E. Bertolucci Electrical nerve stimulation device for nausea control
US5308323A (en) 1988-06-06 1994-05-03 Sumitomo Electric Industries. Ltd. Multiple compartment balloon catheter
GB8814898D0 (en) 1988-06-22 1988-07-27 Evans J M Catheters & methods of manufacture
US4921484A (en) 1988-07-25 1990-05-01 Cordis Corporation Mesh balloon catheter device
US5249585A (en) 1988-07-28 1993-10-05 Bsd Medical Corporation Urethral inserted applicator for prostate hyperthermia
US4920979A (en) 1988-10-12 1990-05-01 Huntington Medical Research Institute Bidirectional helical electrode for nerve stimulation
US4995868A (en) 1988-10-12 1991-02-26 Bard Limited Catheter
US4955377A (en) 1988-10-28 1990-09-11 Lennox Charles D Device and method for heating tissue in a patient's body
US4966597A (en) 1988-11-04 1990-10-30 Cosman Eric R Thermometric cardiac tissue ablation electrode with ultra-sensitive temperature detection
US5094242A (en) 1988-11-07 1992-03-10 Regents Of The University Of California Implantable nerve stimulation device
US5011488A (en) 1988-12-07 1991-04-30 Robert Ginsburg Thrombus extraction system
US5057318A (en) 1988-12-13 1991-10-15 Alza Corporation Delivery system for beneficial agent over a broad range of rates
US5059423A (en) 1988-12-13 1991-10-22 Alza Corporation Delivery system comprising biocompatible beneficial agent formulation
US5458631A (en) 1989-01-06 1995-10-17 Xavier; Ravi Implantable catheter with electrical pulse nerve stimulators and drug delivery system
AU4945490A (en) 1989-01-06 1990-08-01 Angioplasty Systems Inc. Electrosurgical catheter for resolving atherosclerotic plaque
JP2513289B2 (ja) 1989-01-06 1996-07-03 日本電気株式会社 変調装置
US5203772A (en) 1989-01-09 1993-04-20 Pilot Cardiovascular Systems, Inc. Steerable medical device
US5037391A (en) 1989-01-09 1991-08-06 Pilot Cardiovascular Systems, Inc. Steerable angioplasty device
US5779698A (en) 1989-01-18 1998-07-14 Applied Medical Resources Corporation Angioplasty catheter system and method for making same
US4928688A (en) 1989-01-23 1990-05-29 Mieczyslaw Mirowski Method and apparatus for treating hemodynamic disfunction
US4976711A (en) 1989-04-13 1990-12-11 Everest Medical Corporation Ablation catheter with selectively deployable electrodes
US5125928A (en) 1989-04-13 1992-06-30 Everest Medical Corporation Ablation catheter with selectively deployable electrodes
US5078717A (en) 1989-04-13 1992-01-07 Everest Medical Corporation Ablation catheter with selectively deployable electrodes
US5006119A (en) 1989-05-25 1991-04-09 Engineering & Research Associates, Inc. Hollow core coaxial catheter
US20030220521A1 (en) 1989-07-27 2003-11-27 G.D. Searle & Co. Renal-selective prodrugs for control of renal sympathetic nerve activity in the treatment of hypertension
US5282484A (en) 1989-08-18 1994-02-01 Endovascular Instruments, Inc. Method for performing a partial atherectomy
US5156610A (en) 1989-08-18 1992-10-20 Evi Corporation Catheter atherotome
US5211651A (en) 1989-08-18 1993-05-18 Evi Corporation Catheter atherotome
US5071424A (en) 1989-08-18 1991-12-10 Evi Corporation Catheter atherotome
US5002067A (en) 1989-08-23 1991-03-26 Medtronic, Inc. Medical electrical lead employing improved penetrating electrode
CA2067110C (en) 1989-09-08 2001-07-31 John E. Abele Physiologic low stress angioplasty
US5016808A (en) * 1989-09-14 1991-05-21 Cardiac Pacemakers, Inc. Implantable tapered spiral endocardial lead for use in internal defibrillation
US5133365A (en) 1989-09-14 1992-07-28 Cardiac Pacemakers, Inc. Implantable tapered spiral endocardial lead for use in internal defibrillation
US5112614A (en) 1989-09-14 1992-05-12 Alza Corporation Implantable delivery dispenser
US5231386A (en) 1990-07-24 1993-07-27 Home Row, Inc. Keyswitch-integrated pointing assembly
RU1785710C (en) 1989-10-06 1993-01-07 Vremennyj Nauchnyj Kollektiv O Microwave resonant therapeutic device
US4979511A (en) 1989-11-03 1990-12-25 Cyberonics, Inc. Strain relief tether for implantable electrode
US5188837A (en) 1989-11-13 1993-02-23 Nova Pharmaceutical Corporation Lipsopheres for controlled delivery of substances
US5209723A (en) 1990-01-08 1993-05-11 The Curators Of The University Of Missouri Multiple lumen catheter for hemodialysis
US5158564A (en) 1990-02-14 1992-10-27 Angiomed Ag Atherectomy apparatus
US5851206A (en) 1990-03-13 1998-12-22 The Regents Of The University Of California Method and apparatus for endovascular thermal thrombosis and thermal cancer treatment
US5052998A (en) 1990-04-04 1991-10-01 Zimmon David S Indwelling stent and method of use
US5071407A (en) 1990-04-12 1991-12-10 Schneider (U.S.A.) Inc. Radially expandable fixation member
US5193048A (en) 1990-04-27 1993-03-09 Kaufman Dennis R Stun gun with low battery indicator and shutoff timer
US5054501A (en) 1990-05-16 1991-10-08 Brigham & Women's Hospital Steerable guide wire for cannulation of tubular or vascular organs
US5184617A (en) 1990-06-05 1993-02-09 Staodyn, Inc. Output pulse compensation for therapeutic-type electronic devices
US5095905A (en) 1990-06-07 1992-03-17 Medtronic, Inc. Implantable neural electrode
US5190540A (en) 1990-06-08 1993-03-02 Cardiovascular & Interventional Research Consultants, Inc. Thermal balloon angioplasty
GB9013177D0 (en) * 1990-06-13 1990-08-01 Brown Brian H Real-time imaging, etc.
US5499971A (en) 1990-06-15 1996-03-19 Cortrak Medical, Inc. Method for iontophoretically delivering drug adjacent to a heart
ATE123658T1 (de) 1990-06-15 1995-06-15 Cortrak Medical Inc Vorrichtung zur abgabe von medikamenten.
US5498238A (en) 1990-06-15 1996-03-12 Cortrak Medical, Inc. Simultaneous angioplasty and phoretic drug delivery
US5234692A (en) 1990-07-11 1993-08-10 Alza Corporation Delivery device with a protective sleeve
US5234693A (en) 1990-07-11 1993-08-10 Alza Corporation Delivery device with a protective sleeve
US5188602A (en) 1990-07-12 1993-02-23 Interventional Thermodynamics, Inc. Method and device for delivering heat to hollow body organs
US5058584A (en) 1990-08-30 1991-10-22 Medtronic, Inc. Method and apparatus for epidural burst stimulation for angina pectoris
US5170803A (en) 1990-09-28 1992-12-15 Brunswick Biomedical Technologies, Inc. Esophageal displacement electrode
US5111815A (en) 1990-10-15 1992-05-12 Cardiac Pacemakers, Inc. Method and apparatus for cardioverter/pacer utilizing neurosensing
JP3041967B2 (ja) 1990-12-13 2000-05-15 ソニー株式会社 ディジタル信号符号化装置
EP0491979A1 (de) 1990-12-22 1992-07-01 Peter Dr. Ing. Osypka Herzschrittmacher-Katheter mit zwei Polen
US5163928A (en) 1991-01-07 1992-11-17 Franklin Electronic Publishers, Incorporated Self-centering catheter
US5170802A (en) 1991-01-07 1992-12-15 Medtronic, Inc. Implantable electrode for location within a blood vessel
US5324255A (en) 1991-01-11 1994-06-28 Baxter International Inc. Angioplasty and ablative devices having onboard ultrasound components and devices and methods for utilizing ultrasound to treat or prevent vasopasm
US5263480A (en) 1991-02-01 1993-11-23 Cyberonics, Inc. Treatment of eating disorders by nerve stimulation
US5465717A (en) 1991-02-15 1995-11-14 Cardiac Pathways Corporation Apparatus and Method for ventricular mapping and ablation
US5425364A (en) 1991-02-15 1995-06-20 Cardiac Pathways Corporation Flexible strip assembly without feedthrough holes and device utilizing the same
US5228442A (en) * 1991-02-15 1993-07-20 Cardiac Pathways Corporation Method for mapping, ablation, and stimulation using an endocardial catheter
US5345936A (en) * 1991-02-15 1994-09-13 Cardiac Pathways Corporation Apparatus with basket assembly for endocardial mapping
US5329923A (en) 1991-02-15 1994-07-19 Lundquist Ingemar H Torquable catheter
AU660444B2 (en) 1991-02-15 1995-06-29 Ingemar H. Lundquist Torquable catheter and method
US5156151A (en) * 1991-02-15 1992-10-20 Cardiac Pathways Corporation Endocardial mapping and ablation system and catheter probe
US5269303A (en) 1991-02-22 1993-12-14 Cyberonics, Inc. Treatment of dementia by nerve stimulation
US5199428A (en) 1991-03-22 1993-04-06 Medtronic, Inc. Implantable electrical nerve stimulator/pacemaker with ischemia for decreasing cardiac workload
US5188619A (en) 1991-04-24 1993-02-23 Gene E. Myers Enterprises, Inc. Internal thoractic artery catheter
DE4113703C2 (de) 1991-04-26 1995-05-04 Thomas Osypka Führungskatheter mit vorgebogenem Endbereich
US5251634A (en) 1991-05-03 1993-10-12 Cyberonics, Inc. Helical nerve electrode
US5299569A (en) 1991-05-03 1994-04-05 Cyberonics, Inc. Treatment of neuropsychiatric disorders by nerve stimulation
US5215086A (en) 1991-05-03 1993-06-01 Cyberonics, Inc. Therapeutic treatment of migraine symptoms by stimulation
US5335657A (en) 1991-05-03 1994-08-09 Cyberonics, Inc. Therapeutic treatment of sleep disorder by nerve stimulation
US5330496A (en) 1991-05-06 1994-07-19 Alferness Clifton A Vascular catheter assembly for tissue penetration and for cardiac stimulation and methods thereof
WO1992020291A1 (en) * 1991-05-24 1992-11-26 Applied Medical Resources, Inc. Articulating tissue cutter assembly
US5458568A (en) 1991-05-24 1995-10-17 Cortrak Medical, Inc. Porous balloon for selective dilatation and drug delivery
US5137727A (en) 1991-06-12 1992-08-11 Alza Corporation Delivery device providing beneficial agent stability
US5213098A (en) 1991-07-26 1993-05-25 Medtronic, Inc. Post-extrasystolic potentiation stimulation with physiologic sensor feedback
US5222494A (en) 1991-07-31 1993-06-29 Cyberonics, Inc. Implantable tissue stimulator output stabilization system
US5231988A (en) 1991-08-09 1993-08-03 Cyberonics, Inc. Treatment of endocrine disorders by nerve stimulation
JPH066170B2 (ja) * 1991-08-28 1994-01-26 中島 博 ペースメーカのペーシング・リード
CA2120516A1 (en) 1991-10-03 1993-04-15 Ralph De La Torre Apparatus and method for vasodilation
US5215089A (en) 1991-10-21 1993-06-01 Cyberonics, Inc. Electrode assembly for nerve stimulation
US5628775A (en) 1991-11-08 1997-05-13 Ep Technologies, Inc. Flexible bond for sleeves enclosing a bendable electrode tip assembly
ATE241938T1 (de) 1991-11-08 2003-06-15 Boston Scient Ltd Ablationselektrode mit isoliertem temperaturmesselement
US5304206A (en) 1991-11-18 1994-04-19 Cyberonics, Inc. Activation techniques for implantable medical device
US5193540A (en) 1991-12-18 1993-03-16 Alfred E. Mann Foundation For Scientific Research Structure and method of manufacture of an implantable microstimulator
US5358514A (en) 1991-12-18 1994-10-25 Alfred E. Mann Foundation For Scientific Research Implantable microdevice with self-attaching electrodes
US5193539A (en) 1991-12-18 1993-03-16 Alfred E. Mann Foundation For Scientific Research Implantable microstimulator
US5203326A (en) 1991-12-18 1993-04-20 Telectronics Pacing Systems, Inc. Antiarrhythmia pacer using antiarrhythmia pacing and autonomic nerve stimulation therapy
US5301683A (en) 1991-12-23 1994-04-12 Durkan John A Diagnosing carpal tunnel syndrome
US5683366A (en) 1992-01-07 1997-11-04 Arthrocare Corporation System and method for electrosurgical tissue canalization
US5697882A (en) 1992-01-07 1997-12-16 Arthrocare Corporation System and method for electrosurgical cutting and ablation
US5354297A (en) 1992-02-14 1994-10-11 Boaz Avitall Biplanar deflectable catheter for arrhythmogenic tissue ablation
US5327905A (en) 1992-02-14 1994-07-12 Boaz Avitall Biplanar deflectable catheter for arrhythmogenic tissue ablation
US5263493A (en) 1992-02-24 1993-11-23 Boaz Avitall Deflectable loop electrode array mapping and ablation catheter for cardiac chambers
US5300099A (en) 1992-03-06 1994-04-05 Urologix, Inc. Gamma matched, helical dipole microwave antenna
ATE181773T1 (de) 1992-03-09 1999-07-15 Univ Washington Neurographische abbildungsverfahren und diffusions-anistropie
US5239999A (en) 1992-03-27 1993-08-31 Cardiac Pathways Corporation Helical endocardial catheter probe
US5318525A (en) 1992-04-10 1994-06-07 Medtronic Cardiorhythm Steerable electrode catheter
AU4026793A (en) 1992-04-10 1993-11-18 Cardiorhythm Shapable handle for steerable electrode catheter
US5345031A (en) 1992-04-16 1994-09-06 The Trustees Of Princeton University Reduction of aromatic halide content
US5300068A (en) 1992-04-21 1994-04-05 St. Jude Medical, Inc. Electrosurgical apparatus
US5263492A (en) 1992-04-30 1993-11-23 Guy Voyce Recording goniometer
US5443470A (en) * 1992-05-01 1995-08-22 Vesta Medical, Inc. Method and apparatus for endometrial ablation
US5562720A (en) * 1992-05-01 1996-10-08 Vesta Medical, Inc. Bipolar/monopolar endometrial ablation device and method
US5370680A (en) 1992-05-27 1994-12-06 Magnetic Resonance Therapeutics, Inc. Athermapeutic apparatus employing electro-magnetic fields
US5324284A (en) 1992-06-05 1994-06-28 Cardiac Pathways, Inc. Endocardial mapping and ablation system utilizing a separately controlled ablation catheter and method
WO1994000188A1 (en) 1992-06-24 1994-01-06 Cyberonics, Inc. Treatment of neuropsychiatric disorders by nerve stimulation
WO1994000178A1 (en) 1992-06-26 1994-01-06 Schneider (Usa) Inc. Catheter with expandable wire mesh tip
US5772590A (en) * 1992-06-30 1998-06-30 Cordis Webster, Inc. Cardiovascular catheter with laterally stable basket-shaped electrode array with puller wire
US5782239A (en) 1992-06-30 1998-07-21 Cordis Webster, Inc. Unique electrode configurations for cardiovascular electrode catheter with built-in deflection method and central puller wire
US5507724A (en) 1992-07-01 1996-04-16 Genetronics, Inc. Electroporation and iontophoresis apparatus and method for insertion of drugs and genes into cells
US5304120A (en) 1992-07-01 1994-04-19 Btx Inc. Electroporation method and apparatus for insertion of drugs and genes into endothelial cells
US5399164A (en) 1992-11-02 1995-03-21 Catheter Imaging Systems Catheter having a multiple durometer
US5542916A (en) 1992-08-12 1996-08-06 Vidamed, Inc. Dual-channel RF power delivery system
US5484400A (en) 1992-08-12 1996-01-16 Vidamed, Inc. Dual channel RF delivery system
US6623516B2 (en) 1992-08-13 2003-09-23 Mark A. Saab Method for changing the temperature of a selected body region
US5437288A (en) 1992-09-04 1995-08-01 Mayo Foundation For Medical Education And Research Flexible catheter guidewire
DE4229693A1 (de) 1992-09-05 1994-03-10 Achim Dr Hansjuergens Elektrotherapeutisches Gerät
US5922340A (en) 1992-09-10 1999-07-13 Children's Medical Center Corporation High load formulations and methods for providing prolonged local anesthesia
US5700485A (en) 1992-09-10 1997-12-23 Children's Medical Center Corporation Prolonged nerve blockade by the combination of local anesthetic and glucocorticoid
EP0659073B1 (en) 1992-09-10 2001-12-19 Children's Medical Center Corporation Biodegradable polymer matrices for sustained delivery of local anesthetic agents
US5478303A (en) 1992-09-18 1995-12-26 Foley-Nolan; Darragh Electromagnetic apparatus for use in therapy
US5338662A (en) 1992-09-21 1994-08-16 Bio-Preserve Medical Corporation Organ perfusion device
US5553611A (en) 1994-01-06 1996-09-10 Endocardial Solutions, Inc. Endocardial measurement method
EP0668740A4 (en) * 1992-09-25 1998-10-07 Ep Technologies STRIP-SHAPED CARRIER FOR ELECTRODES FOR DIAGNOSTICS AND THERAPY OF HEART COMBUSTS.
WO1994007446A1 (en) 1992-10-05 1994-04-14 Boston Scientific Corporation Device and method for heating tissue
US5634899A (en) 1993-08-20 1997-06-03 Cortrak Medical, Inc. Simultaneous cardiac pacing and local drug delivery method
US5336178A (en) * 1992-11-02 1994-08-09 Localmed, Inc. Intravascular catheter with infusion array
US5807306A (en) 1992-11-09 1998-09-15 Cortrak Medical, Inc. Polymer matrix drug delivery apparatus
US5334193A (en) 1992-11-13 1994-08-02 American Cardiac Ablation Co., Inc. Fluid cooled ablation catheter
US5441483A (en) 1992-11-16 1995-08-15 Avitall; Boaz Catheter deflection control
US5328442A (en) * 1992-11-20 1994-07-12 Siemens Pacesetter, Inc. System and method for stimulating a heart having undergone cardiac myoplasty using a single-chamber pacemaker
CA2109980A1 (en) 1992-12-01 1994-06-02 Mir A. Imran Steerable catheter with adjustable bend location and/or radius and method
SE9203733D0 (sv) 1992-12-11 1992-12-11 Siemens Elema Ab Defibrilleringselektrod
US5256141A (en) 1992-12-22 1993-10-26 Nelson Gencheff Biological material deployment method and apparatus
US5317155A (en) 1992-12-29 1994-05-31 The Electrogesic Corporation Corona discharge apparatus
US5429634A (en) 1993-09-09 1995-07-04 Pdt Systems Biogenic implant for drug delivery and method
US5387233A (en) 1993-01-11 1995-02-07 Incontrol, Inc. Intravenous cardiac lead with improved fixation and method
IT1266217B1 (it) 1993-01-18 1996-12-27 Xtrode Srl Elettrocatetere per la mappatura e l'intervento su cavita' cardiache.
US5706809A (en) * 1993-01-29 1998-01-13 Cardima, Inc. Method and system for using multiple intravascular sensing devices to detect electrical activity
US6620188B1 (en) 1998-08-24 2003-09-16 Radiant Medical, Inc. Methods and apparatus for regional and whole body temperature modification
US5792187A (en) 1993-02-22 1998-08-11 Angeion Corporation Neuro-stimulation to control pain during cardioversion defibrillation
US5569274A (en) 1993-02-22 1996-10-29 Heartport, Inc. Endoscopic vascular clamping system and method
US5476495A (en) 1993-03-16 1995-12-19 Ep Technologies, Inc. Cardiac mapping and ablation systems
WO1994021168A1 (en) 1993-03-16 1994-09-29 Ep Technologies, Inc. Cardiac mapping and ablation systems
US5636634A (en) 1993-03-16 1997-06-10 Ep Technologies, Inc. Systems using guide sheaths for introducing, deploying, and stabilizing cardiac mapping and ablation probes
JP3345786B2 (ja) 1993-03-17 2002-11-18 ジャパンゴアテックス株式会社 可とう性チューブ及びその製造方法
US5383856A (en) 1993-03-19 1995-01-24 Bersin; Robert M. Helical spiral balloon catheter
US5397338A (en) 1993-03-29 1995-03-14 Maven Labs, Inc. Electrotherapy device
US5439440A (en) 1993-04-01 1995-08-08 Genetronics, Inc. Electroporation system with voltage control feedback for clinical applications
US5523092A (en) 1993-04-14 1996-06-04 Emory University Device for local drug delivery and methods for using the same
FR2704151B1 (fr) 1993-04-21 1995-07-13 Klotz Antoine Olivier Dispositif électronique destiné à la stimulation adrénergique du système sympathique relatif à la média veineuse.
JPH08508880A (ja) 1993-04-21 1996-09-24 アンスティテュ パストゥール 生体内に治療用化合物を発現・分泌させるための生体適合移植片
US5716410A (en) 1993-04-30 1998-02-10 Scimed Life Systems, Inc. Temporary stent and method of use
US6517811B2 (en) 1993-05-06 2003-02-11 Research Corporation Technologies, Inc. Compounds for cancer imaging and therapy
US5693082A (en) 1993-05-14 1997-12-02 Fidus Medical Technology Corporation Tunable microwave ablation catheter system and method
US5611777A (en) 1993-05-14 1997-03-18 C.R. Bard, Inc. Steerable electrode catheter
US5584863A (en) 1993-06-24 1996-12-17 Electropharmacology, Inc. Pulsed radio frequency electrotherapeutic system
US5860974A (en) 1993-07-01 1999-01-19 Boston Scientific Corporation Heart ablation catheter with expandable electrode and method of coupling energy to an electrode on a catheter shaft
CA2165829A1 (en) 1993-07-01 1995-01-19 John E. Abele Imaging, electrical potential sensing, and ablation catheters
US5545200A (en) 1993-07-20 1996-08-13 Medtronic Cardiorhythm Steerable electrophysiology catheter
US5487757A (en) 1993-07-20 1996-01-30 Medtronic Cardiorhythm Multicurve deflectable catheter
US5415633A (en) 1993-07-28 1995-05-16 Active Control Experts, Inc. Remotely steered catheterization device
US5458585A (en) 1993-07-28 1995-10-17 Cardiovascular Imaging Systems, Inc. Tracking tip for a work element in a catheter system
US5405374A (en) 1993-08-25 1995-04-11 Medtronic, Inc. Transvenous defibrillation lead and method of use
US5431649A (en) 1993-08-27 1995-07-11 Medtronic, Inc. Method and apparatus for R-F ablation
US5980516A (en) 1993-08-27 1999-11-09 Medtronic, Inc. Method and apparatus for R-F ablation
US5807395A (en) 1993-08-27 1998-09-15 Medtronic, Inc. Method and apparatus for RF ablation and hyperthermia
US5507791A (en) 1993-08-31 1996-04-16 Sit'ko; Sergei P. Microwave resonance therapy
US5427118A (en) 1993-10-04 1995-06-27 Baxter International Inc. Ultrasonic guidewire
US5673695A (en) 1995-08-02 1997-10-07 Ep Technologies, Inc. Methods for locating and ablating accessory pathways in the heart
US5582609A (en) 1993-10-14 1996-12-10 Ep Technologies, Inc. Systems and methods for forming large lesions in body tissue using curvilinear electrode elements
US6129724A (en) 1993-10-14 2000-10-10 Ep Technologies, Inc. Systems and methods for forming elongated lesion patterns in body tissue using straight or curvilinear electrode elements
EP0754075B1 (en) 1993-10-14 2006-03-15 Boston Scientific Limited Electrode elements for forming lesion patterns
WO1995010225A1 (en) 1993-10-15 1995-04-20 Ep Technologies, Inc. Multiple electrode element for mapping and ablating
US5400784A (en) 1993-10-15 1995-03-28 Case Western Reserve University Slowly penetrating inter-fascicular nerve cuff electrode and method of using
WO1995010322A1 (en) 1993-10-15 1995-04-20 Ep Technologies, Inc. Creating complex lesion patterns in body tissue
WO1995010319A1 (en) 1993-10-15 1995-04-20 Ep Technologies, Inc. Electrodes for creating lesions in body tissue
US5545193A (en) 1993-10-15 1996-08-13 Ep Technologies, Inc. Helically wound radio-frequency emitting electrodes for creating lesions in body tissue
US5575810A (en) 1993-10-15 1996-11-19 Ep Technologies, Inc. Composite structures and methods for ablating tissue to form complex lesion patterns in the treatment of cardiac conditions and the like
US5397308A (en) 1993-10-22 1995-03-14 Scimed Life Systems, Inc. Balloon inflation measurement apparatus
US5470352A (en) 1993-10-29 1995-11-28 Northeastern University Balloon angioplasty device
US5571147A (en) 1993-11-02 1996-11-05 Sluijter; Menno E. Thermal denervation of an intervertebral disc for relief of back pain
US5433739A (en) 1993-11-02 1995-07-18 Sluijter; Menno E. Method and apparatus for heating an intervertebral disc for relief of back pain
US5564440A (en) 1993-11-03 1996-10-15 Daig Corporation Method for mopping and/or ablation of anomalous conduction pathways
US5497774A (en) 1993-11-03 1996-03-12 Daig Corporation Guiding introducer for left atrium
US5575766A (en) 1993-11-03 1996-11-19 Daig Corporation Process for the nonsurgical mapping and treatment of atrial arrhythmia using catheters guided by shaped guiding introducers
US5599345A (en) 1993-11-08 1997-02-04 Zomed International, Inc. RF treatment apparatus
US5507743A (en) 1993-11-08 1996-04-16 Zomed International Coiled RF electrode treatment apparatus
DE69433213T2 (de) 1993-11-10 2004-05-06 Medtronic, Inc., Minneapolis Katheter mit Elektrodenanordnung
US5730127A (en) 1993-12-03 1998-03-24 Avitall; Boaz Mapping and ablation catheter system
US5487385A (en) 1993-12-03 1996-01-30 Avitall; Boaz Atrial mapping and ablation catheter system
JPH07157424A (ja) 1993-12-03 1995-06-20 Lintec Corp 局所麻酔用ゲル製剤
CA2138076A1 (en) 1993-12-17 1995-06-18 Philip E. Eggers Monopolar electrosurgical instruments
US5458626A (en) 1993-12-27 1995-10-17 Krause; Horst E. Method of electrical nerve stimulation for acceleration of tissue healing
US6099524A (en) 1994-01-28 2000-08-08 Cardiac Pacemakers, Inc. Electrophysiological mapping and ablation catheter and method
US5462545A (en) 1994-01-31 1995-10-31 New England Medical Center Hospitals, Inc. Catheter electrodes
US5697975A (en) 1994-02-09 1997-12-16 The University Of Iowa Research Foundation Human cerebral cortex neural prosthetic for tinnitus
US6858024B1 (en) 1994-02-14 2005-02-22 Scimed Life Systems, Inc. Guide catheter having selected flexural modulus segments
WO1995024160A1 (en) * 1994-03-08 1995-09-14 Cardima, Inc. Intravascular rf occlusion catheter
GB9407135D0 (en) 1994-04-11 1994-06-01 Aberdeen University And Plasma Treatment of osteoporosis
US5505201A (en) 1994-04-20 1996-04-09 Case Western Reserve University Implantable helical spiral cuff electrode
US5882333A (en) 1994-05-13 1999-03-16 Cardima, Inc. Catheter with deflectable distal section
WO1995033514A1 (en) 1994-06-09 1995-12-14 Magnetic Resonance Therapeutics, Inc. Electro-therapeutic method
US5505700A (en) * 1994-06-14 1996-04-09 Cordis Corporation Electro-osmotic infusion catheter
US5421349A (en) 1994-06-16 1995-06-06 Cordis Corporation Atraumatic proximal guidewire end
US5617854A (en) 1994-06-22 1997-04-08 Munsif; Anand Shaped catheter device and method
US6056744A (en) * 1994-06-24 2000-05-02 Conway Stuart Medical, Inc. Sphincter treatment apparatus
US6009877A (en) 1994-06-24 2000-01-04 Edwards; Stuart D. Method for treating a sphincter
US6405732B1 (en) 1994-06-24 2002-06-18 Curon Medical, Inc. Method to treat gastric reflux via the detection and ablation of gastro-esophageal nerves and receptors
WO1996000039A1 (en) 1994-06-27 1996-01-04 Ep Technologies, Inc. Systems and methods for sensing temperature within the body
EP0768841B1 (en) 1994-06-27 2003-12-03 Boston Scientific Limited System for controlling tissue ablation using temperature sensors
US5680860A (en) 1994-07-07 1997-10-28 Cardiac Pathways Corporation Mapping and/or ablation catheter with coilable distal extremity and method for using same
US5690611A (en) 1994-07-08 1997-11-25 Daig Corporation Process for the treatment of atrial arrhythima using a catheter guided by shaped giding introducers
US5626862A (en) 1994-08-02 1997-05-06 Massachusetts Institute Of Technology Controlled local delivery of chemotherapeutic agents for treating solid tumors
US5810802A (en) 1994-08-08 1998-09-22 E.P. Technologies, Inc. Systems and methods for controlling tissue ablation using multiple temperature sensing elements
US5514092A (en) 1994-08-08 1996-05-07 Schneider (Usa) Inc. Drug delivery and dilatation-drug delivery catheters in a rapid exchange configuration
US5454782A (en) 1994-08-11 1995-10-03 Perkins; Rodney C. Translumenal circumferential energy delivery device
US5476498A (en) 1994-08-15 1995-12-19 Incontrol, Inc. Coronary sinus channel lead and method
EP0776235A4 (en) 1994-08-17 1999-08-25 Magnetic Resonance Therapeutic ELECTROTHERAPEUTIC SYSTEM
US5609151A (en) 1994-09-08 1997-03-11 Medtronic, Inc. Method for R-F ablation
US5519172A (en) 1994-09-13 1996-05-21 W. L. Gore & Associates, Inc. Jacket material for protection of electrical conductors
US5531778A (en) 1994-09-20 1996-07-02 Cyberonics, Inc. Circumneural electrode assembly
US5545475A (en) 1994-09-20 1996-08-13 W. L. Gore & Associates Microfiber-reinforced porous polymer film and a method for manufacturing the same and composites made thereof
US5540734A (en) 1994-09-28 1996-07-30 Zabara; Jacob Cranial nerve stimulation treatments using neurocybernetic prosthesis
US5509909A (en) 1994-10-06 1996-04-23 Moy; Grant G. Bent chest tube assembly
US5885278A (en) 1994-10-07 1999-03-23 E.P. Technologies, Inc. Structures for deploying movable electrode elements
US6142994A (en) 1994-10-07 2000-11-07 Ep Technologies, Inc. Surgical method and apparatus for positioning a diagnostic a therapeutic element within the body
WO1996011723A1 (en) 1994-10-17 1996-04-25 Australasian Medical Technology Limited Devices and methods for implementation of pulsed electromagnetic field therapy
US5722401A (en) 1994-10-19 1998-03-03 Cardiac Pathways Corporation Endocardial mapping and/or ablation catheter probe
US5810742A (en) 1994-10-24 1998-09-22 Transcan Research & Development Co., Ltd. Tissue characterization based on impedance images and on impedance measurements
US5660848A (en) 1994-11-02 1997-08-26 The Population Council, Center For Biomedical Research Subdermally implantable device
ATE232089T1 (de) 1994-11-10 2003-02-15 Univ Kentucky Res Found Implantierbare wiederauffüllbare vorrichtung mit gesteuerter freisetzung zur verabreichung von arzneistoffen unmittelbar an einen inneren teil des körpers
US5571150A (en) 1994-12-19 1996-11-05 Cyberonics, Inc. Treatment of patients in coma by nerve stimulation
US5569198A (en) 1995-01-23 1996-10-29 Cortrak Medical Inc. Microporous catheter
GB9501424D0 (en) 1995-01-25 1995-03-15 Carrie Len Epidural catheter
US5595183A (en) * 1995-02-17 1997-01-21 Ep Technologies, Inc. Systems and methods for examining heart tissue employing multiple electrode structures and roving electrodes
DE19507929A1 (de) 1995-02-24 1996-09-05 Biotronik Mess & Therapieg Elektrodensystem zur Messung des monophasischen Aktionspotentials
EP0827383B1 (en) 1995-02-28 2007-05-30 Boston Scientific Corporation Polymer implements for torque transmission
EP0814729B1 (en) 1995-03-10 2000-08-09 Impra, Inc. Endoluminal encapsulated stent and methods of manufacture
US5676662A (en) 1995-03-17 1997-10-14 Daig Corporation Ablation catheter
US5916178A (en) 1995-03-30 1999-06-29 Medtronic, Inc. Steerable high support guidewire with thin wall nitinol tube
NL1000183C2 (nl) 1995-04-20 1996-10-22 Clemens Josephus Jacobs Catheter.
AU5558096A (en) 1995-05-01 1996-11-21 Medtronic Cardiorhythm Dual curve ablation catheter and method
US5681280A (en) 1995-05-02 1997-10-28 Heart Rhythm Technologies, Inc. Catheter control system
WO1996034571A1 (en) 1995-05-04 1996-11-07 Cosman Eric R Cool-tip electrode thermosurgery system
WO1996038196A1 (en) 1995-06-02 1996-12-05 Guided Medical Systems, Inc. Composite guide catheter of adjustable shape
US5984907A (en) 1995-06-05 1999-11-16 Ep Technologies, Inc. Transition sleeve assembly for catheters
US5540730A (en) 1995-06-06 1996-07-30 Cyberonics, Inc. Treatment of motility disorders by nerve stimulation
US6041252A (en) 1995-06-07 2000-03-21 Ichor Medical Systems Inc. Drug delivery system and method
CA2190628C (en) 1995-06-07 2000-05-30 Mark D. Butler An implantable containment apparatus for a therapeutical device and method for loading and reloading the device therein
US6090104A (en) 1995-06-07 2000-07-18 Cordis Webster, Inc. Catheter with a spirally wound flat ribbon electrode
US6322558B1 (en) 1995-06-09 2001-11-27 Engineering & Research Associates, Inc. Apparatus and method for predicting ablation depth
AU706541B2 (en) 1995-06-09 1999-06-17 Euro-Celtique S.A. Formulations and methods for providing prolonged local anesthesia
US5983131A (en) 1995-08-11 1999-11-09 Massachusetts Institute Of Technology Apparatus and method for electroporation of tissue
US5672174A (en) 1995-08-15 1997-09-30 Rita Medical Systems, Inc. Multiple antenna ablation apparatus and method
US5711326A (en) 1995-08-25 1998-01-27 Whirlpool Corporation Dishwasher accumulator soil removal grating for a filter system
US5860922A (en) * 1995-09-07 1999-01-19 Technion Research And Development Foundation Ltd. Determining blood flow by measurement of temperature
US5707400A (en) 1995-09-19 1998-01-13 Cyberonics, Inc. Treating refractory hypertension by nerve stimulation
US6615071B1 (en) 1995-09-20 2003-09-02 Board Of Regents, The University Of Texas System Method and apparatus for detecting vulnerable atherosclerotic plaque
ATE221338T1 (de) 1995-09-20 2002-08-15 Texas Heart Inst Ynzeige von thermischen unstetigkeiten an gefässwänden
US6283951B1 (en) 1996-10-11 2001-09-04 Transvascular, Inc. Systems and methods for delivering drugs to selected locations within the body
US5700282A (en) 1995-10-13 1997-12-23 Zabara; Jacob Heart rhythm stabilization using a neurocybernetic prosthesis
JPH11514269A (ja) 1995-10-13 1999-12-07 トランスバスキュラー インコーポレイテッド 動脈閉塞にバイパスを形成するためのおよび／またはその他の経血管的手法を実施するための方法および装置
US6283960B1 (en) 1995-10-24 2001-09-04 Oratec Interventions, Inc. Apparatus for delivery of energy to a surgical site
US5755750A (en) 1995-11-13 1998-05-26 University Of Florida Method and apparatus for selectively inhibiting activity in nerve fibers
US6073048A (en) 1995-11-17 2000-06-06 Medtronic, Inc. Baroreflex modulation with carotid sinus nerve stimulation for the treatment of heart failure
US5823955A (en) 1995-11-20 1998-10-20 Medtronic Cardiorhythm Atrioventricular valve tissue ablation catheter and method
SE9504333D0 (sv) 1995-12-04 1995-12-04 Pacesetter Ab Styrtrådsenhet
US6010613A (en) 1995-12-08 2000-01-04 Cyto Pulse Sciences, Inc. Method of treating materials with pulsed electrical fields
DE19546941A1 (de) 1995-12-15 1997-06-19 Biotronik Mess & Therapieg Einzel-Elektrode für Zweikammer-Herzschrittmachersysteme, insbesondere für DDD-Herzschrittmachersysteme
CN2291164Y (zh) 1996-12-23 1998-09-16 祝强 降压仪
ES2206684T3 (es) 1996-02-02 2004-05-16 Transvascular, Inc. Sistema para una intervencion transvascular intersticial.
EP1249229A3 (en) 1996-02-02 2005-02-02 ALZA Corporation Sustained delivery of an active agent using an implantable system
US5895398A (en) 1996-02-02 1999-04-20 The Regents Of The University Of California Method of using a clot capture coil
US5807249A (en) 1996-02-16 1998-09-15 Medtronic, Inc. Reduced stiffness, bidirectionally deflecting catheter assembly
US5913876A (en) 1996-02-20 1999-06-22 Cardiothoracic Systems, Inc. Method and apparatus for using vagus nerve stimulation in surgery
US6051017A (en) 1996-02-20 2000-04-18 Advanced Bionics Corporation Implantable microstimulator and systems employing the same
US6436056B1 (en) 1996-02-28 2002-08-20 Boston Scientific Corporation Polymeric implements for torque transmission
US6036687A (en) 1996-03-05 2000-03-14 Vnus Medical Technologies, Inc. Method and apparatus for treating venous insufficiency
US6032077A (en) 1996-03-06 2000-02-29 Cardiac Pathways Corporation Ablation catheter with electrical coupling via foam drenched with a conductive fluid
US5755760A (en) 1996-03-11 1998-05-26 Medtronic, Inc. Deflectable catheter
US5997526A (en) 1996-03-25 1999-12-07 The Uab Research Foundation Shape memory catheter
JP3529537B2 (ja) 1996-03-25 2004-05-24 テルモ株式会社 電極カテーテル
US5747060A (en) 1996-03-26 1998-05-05 Euro-Celtique, S.A. Prolonged local anesthesia with colchicine
US5690681A (en) 1996-03-29 1997-11-25 Purdue Research Foundation Method and apparatus using vagal stimulation for control of ventricular rate during atrial fibrillation
US5755761A (en) 1996-04-26 1998-05-26 Pharmatarget, Inc. Atrial pacing catheter and method having multiple electrodes in the right atrium and coronary sinus
US6006134A (en) 1998-04-30 1999-12-21 Medtronic, Inc. Method and device for electronically controlling the beating of a heart using venous electrical stimulation of nerve fibers
US6735471B2 (en) 1996-04-30 2004-05-11 Medtronic, Inc. Method and system for endotracheal/esophageal stimulation prior to and during a medical procedure
US6449507B1 (en) 1996-04-30 2002-09-10 Medtronic, Inc. Method and system for nerve stimulation prior to and during a medical procedure
US5690691A (en) 1996-05-08 1997-11-25 The Center For Innovative Technology Gastro-intestinal pacemaker having phased multi-point stimulation
US6042578A (en) 1996-05-13 2000-03-28 Schneider (Usa) Inc. Catheter reinforcing braids
US5713923A (en) 1996-05-13 1998-02-03 Medtronic, Inc. Techniques for treating epilepsy by brain stimulation and drug infusion
US5938690A (en) 1996-06-07 1999-08-17 Advanced Neuromodulation Systems, Inc. Pain management system and method
US5824026A (en) 1996-06-12 1998-10-20 The Spectranetics Corporation Catheter for delivery of electric energy and a process for manufacturing same
US5861021A (en) 1996-06-17 1999-01-19 Urologix Inc Microwave thermal therapy of cardiac tissue
US6546280B2 (en) 1996-06-18 2003-04-08 Cook Incorporated Indwelling catheter
US6223070B1 (en) 1998-03-16 2001-04-24 Cook, Inc. Indwelling catheter
US5727555A (en) 1996-06-18 1998-03-17 Cook Incorporated Indwelling catheter
US5827242A (en) 1996-06-21 1998-10-27 Medtronic, Inc. Reinforced catheter body and method for its fabrication
US20020040204A1 (en) 1996-06-24 2002-04-04 Dev Nagendu B. Electroporation-enhanced inhibition of vascular neointimal hyperplasia
US6246912B1 (en) 1996-06-27 2001-06-12 Sherwood Services Ag Modulated high frequency tissue modification
US5983141A (en) 1996-06-27 1999-11-09 Radionics, Inc. Method and apparatus for altering neural tissue function
US5882346A (en) 1996-07-15 1999-03-16 Cardiac Pathways Corporation Shapable catheter using exchangeable core and method of use
US5972019A (en) 1996-07-25 1999-10-26 Target Therapeutics, Inc. Mechanical clot treatment device
US6245026B1 (en) 1996-07-29 2001-06-12 Farallon Medsystems, Inc. Thermography catheter
US5924997A (en) 1996-07-29 1999-07-20 Campbell; Thomas Henderson Catheter and method for the thermal mapping of hot spots in vascular lesions of the human body
US6058328A (en) 1996-08-06 2000-05-02 Pacesetter, Inc. Implantable stimulation device having means for operating in a preemptive pacing mode to prevent tachyarrhythmias and method thereof
US5800494A (en) 1996-08-20 1998-09-01 Fidus Medical Technology Corporation Microwave ablation catheters having antennas with distal fire capabilities
US5906636A (en) 1996-09-20 1999-05-25 Texas Heart Institute Heat treatment of inflamed tissue
US5697928A (en) 1996-09-23 1997-12-16 Uab Research Foundation Cardic electrode catheter
US5954740A (en) 1996-09-23 1999-09-21 Boston Scientific Corporation Catheter balloon having raised radial segments
US5891134A (en) 1996-09-24 1999-04-06 Goble; Colin System and method for applying thermal energy to tissue
US5800464A (en) 1996-10-03 1998-09-01 Medtronic, Inc. System for providing hyperpolarization of cardiac to enhance cardiac function
US5814079A (en) 1996-10-04 1998-09-29 Medtronic, Inc. Cardiac arrhythmia management by application of adnodal stimulation for hyperpolarization of myocardial cells
US5704908A (en) 1996-10-10 1998-01-06 Genetronics, Inc. Electroporation and iontophoresis catheter with porous balloon
US7052493B2 (en) 1996-10-22 2006-05-30 Epicor Medical, Inc. Methods and devices for ablation
US6096036A (en) 1998-05-05 2000-08-01 Cardiac Pacemakers, Inc. Steerable catheter with preformed distal shape and method for use
US5827268A (en) 1996-10-30 1998-10-27 Hearten Medical, Inc. Device for the treatment of patent ductus arteriosus and method of using the device
US5893885A (en) 1996-11-01 1999-04-13 Cordis Webster, Inc. Multi-electrode ablation catheter
US6091995A (en) 1996-11-08 2000-07-18 Surx, Inc. Devices, methods, and systems for shrinking tissues
US5910150A (en) 1996-12-02 1999-06-08 Angiotrax, Inc. Apparatus for performing surgery
US5954719A (en) 1996-12-11 1999-09-21 Irvine Biomedical, Inc. System for operating a RF ablation generator
US5910129A (en) 1996-12-19 1999-06-08 Ep Technologies, Inc. Catheter distal assembly with pull wires
US6048329A (en) 1996-12-19 2000-04-11 Ep Technologies, Inc. Catheter distal assembly with pull wires
US6076012A (en) 1996-12-19 2000-06-13 Ep Technologies, Inc. Structures for supporting porous electrode elements
US5871449A (en) 1996-12-27 1999-02-16 Brown; David Lloyd Device and method for locating inflamed plaque in an artery
WO1998030279A1 (en) 1997-01-13 1998-07-16 Neurodan A/S An implantable nerve stimulator electrode
US6026326A (en) 1997-01-13 2000-02-15 Medtronic, Inc. Apparatus and method for treating chronic constipation
US5744710A (en) * 1997-01-17 1998-04-28 Lockheed Martin Corp. Fast maximum likelihood processor for means wind velocity estimation
SE9700373L (sv) 1997-02-04 1998-07-13 Stig Bengmark Sond för åstadkommande av fluidumförbindelse med tunntarmen
US5730741A (en) 1997-02-07 1998-03-24 Eclipse Surgical Technologies, Inc. Guided spiral catheter
US5873865A (en) 1997-02-07 1999-02-23 Eclipse Surgical Technologies, Inc. Spiral catheter with multiple guide holes
JP2002515801A (ja) 1997-02-12 2002-05-28 オーレイテック インターヴェンションズ インコーポレイテッド 関節鏡による手術のための凹状探針
EP1666087A3 (en) 1997-02-26 2009-04-29 The Alfred E Mann Foundation for Scientific Research Battery-powered patient implantable device
US6208894B1 (en) 1997-02-26 2001-03-27 Alfred E. Mann Foundation For Scientific Research And Advanced Bionics System of implantable devices for monitoring and/or affecting body parameters
US5899898A (en) 1997-02-27 1999-05-04 Cryocath Technologies Inc. Cryosurgical linear ablation
US6416510B1 (en) 1997-03-13 2002-07-09 Biocardia, Inc. Drug delivery catheters that attach to tissue and methods for their use
US6086582A (en) 1997-03-13 2000-07-11 Altman; Peter A. Cardiac drug delivery system
US5954761A (en) 1997-03-25 1999-09-21 Intermedics Inc. Implantable endocardial lead assembly having a stent
EP1011804B1 (en) 1997-03-27 2009-08-19 Alfred E. Mann Foundation System of implantable devices for monitoring and/or affecting body parameters
AU6112798A (en) 1997-03-31 1998-10-22 Biosense, Inc. Deflectable catheter
JP3274384B2 (ja) 1997-03-31 2002-04-15 株式会社パイオラックス 留置カテーテル及びその挿入装置
US5879295A (en) 1997-04-02 1999-03-09 Medtronic, Inc. Enhanced contact steerable bowing electrode catheter assembly
US6261281B1 (en) 1997-04-03 2001-07-17 Electrofect As Method for genetic immunization and introduction of molecules into skeletal muscle and immune cells
US5876373A (en) 1997-04-04 1999-03-02 Eclipse Surgical Technologies, Inc. Steerable catheter
US5972026A (en) 1997-04-07 1999-10-26 Broncus Technologies, Inc. Bronchial stenter having diametrically adjustable electrodes
US7027869B2 (en) 1998-01-07 2006-04-11 Asthmatx, Inc. Method for treating an asthma attack
US5865815A (en) 1997-04-25 1999-02-02 Contimed, Inc. Prostatic obstruction relief catheter
US6078840A (en) 1997-04-30 2000-06-20 Medtronic, Inc. Medical electrical lead having improved fixation
US5948007A (en) 1997-04-30 1999-09-07 Medtronic, Inc. Dual channel implantation neurostimulation techniques
US6024740A (en) 1997-07-08 2000-02-15 The Regents Of The University Of California Circumferential ablation device assembly
US5971983A (en) 1997-05-09 1999-10-26 The Regents Of The University Of California Tissue ablation device and method of use
US6012457A (en) 1997-07-08 2000-01-11 The Regents Of The University Of California Device and method for forming a circumferential conduction block in a pulmonary vein
US6326020B1 (en) 1997-05-16 2001-12-04 Children's Medical Center Corporation Local anesthetic formulations
US5827278A (en) 1997-05-20 1998-10-27 Cordis Webster, Inc. Deflectable tip electrode catheter with nylon stiffener and compression coil
DE69840444D1 (de) 1997-05-23 2009-02-26 Prorhythm Inc Wegwerfbarer fokussierender ultraschallapplikator hoher intensität
US6152912A (en) 1997-06-10 2000-11-28 Target Therapeutics, Inc. Optimized high performance spiral-wound vascular catheter
US5951539A (en) 1997-06-10 1999-09-14 Target Therpeutics, Inc. Optimized high performance multiple coil spiral-wound vascular catheter
US20030109778A1 (en) 1997-06-20 2003-06-12 Cardiac Assist Devices, Inc. Electrophysiology/ablation catheter and remote actuator therefor
US6161048A (en) 1997-06-26 2000-12-12 Radionics, Inc. Method and system for neural tissue modification
WO1999000060A1 (en) 1997-06-26 1999-01-07 Advanced Coronary Intervention Electrosurgical catheter for resolving obstructions by radio frequency ablation
US6251109B1 (en) 1997-06-27 2001-06-26 Daig Corporation Process and device for the treatment of atrial arrhythmia
AU739384B2 (en) 1997-07-02 2001-10-11 Euro-Celtique S.A. Prolonged anesthesia in joints and body spaces
US6966908B2 (en) 1997-07-08 2005-11-22 Atrionix, Inc. Tissue ablation device assembly and method for electrically isolating a pulmonary vein ostium from an atrial wall
US6164283A (en) 1997-07-08 2000-12-26 The Regents Of The University Of California Device and method for forming a circumferential conduction block in a pulmonary vein
US6500174B1 (en) 1997-07-08 2002-12-31 Atrionix, Inc. Circumferential ablation device assembly and methods of use and manufacture providing an ablative circumferential band along an expandable member
US6514249B1 (en) 1997-07-08 2003-02-04 Atrionix, Inc. Positioning system and method for orienting an ablation element within a pulmonary vein ostium
IL133901A (en) 1997-07-08 2005-09-25 Univ Emory Circumferential ablation device assembly and method
US6869431B2 (en) 1997-07-08 2005-03-22 Atrionix, Inc. Medical device with sensor cooperating with expandable member
US6652515B1 (en) 1997-07-08 2003-11-25 Atrionix, Inc. Tissue ablation device assembly and method for electrically isolating a pulmonary vein ostium from an atrial wall
US6117101A (en) 1997-07-08 2000-09-12 The Regents Of The University Of California Circumferential ablation device assembly
ATE353689T1 (de) 1997-07-16 2007-03-15 Metacure Nv Einrichtung zur steuerung eines glatten muskels
US6080151A (en) 1997-07-21 2000-06-27 Daig Corporation Ablation catheter
US6014579A (en) * 1997-07-21 2000-01-11 Cardiac Pathways Corp. Endocardial mapping catheter with movable electrode
US6125302A (en) 1997-09-02 2000-09-26 Advanced Bionics Corporation Precurved modiolar-hugging cochlear electrode
WO1999011313A1 (en) 1997-09-04 1999-03-11 Alcon Laboratories, Inc. Flexible tube with circular grooves of varying width and depth
US6258084B1 (en) 1997-09-11 2001-07-10 Vnus Medical Technologies, Inc. Method for applying energy to biological tissue including the use of tumescent tissue compression
US6200312B1 (en) * 1997-09-11 2001-03-13 Vnus Medical Technologies, Inc. Expandable vein ligator catheter having multiple electrode leads
US5871531A (en) 1997-09-25 1999-02-16 Medtronic, Inc. Medical electrical lead having tapered spiral fixation
US5891114A (en) 1997-09-30 1999-04-06 Target Therapeutics, Inc. Soft-tip high performance braided catheter
US6048338A (en) 1997-10-15 2000-04-11 Scimed Life Systems, Inc. Catheter with spiral cut transition member
AU1190699A (en) 1997-10-20 1999-05-10 Robert D. Bersin Helical spiral balloon catheter
US6156046A (en) 1997-11-07 2000-12-05 Prolifix Medical, Inc. Methods and systems for treating obstructions in a body lumen
WO1999023958A1 (en) 1997-11-07 1999-05-20 Prolifix Medical, Inc. Methods and systems for treating obstructions in a body lumen
US6120500A (en) 1997-11-12 2000-09-19 Daig Corporation Rail catheter ablation and mapping system
US6120476A (en) 1997-12-01 2000-09-19 Cordis Webster, Inc. Irrigated tip catheter
US6917834B2 (en) 1997-12-03 2005-07-12 Boston Scientific Scimed, Inc. Devices and methods for creating lesions in endocardial and surrounding tissue to isolate focal arrhythmia substrates
US6280441B1 (en) 1997-12-15 2001-08-28 Sherwood Services Ag Apparatus and method for RF lesioning
US6699231B1 (en) 1997-12-31 2004-03-02 Heartport, Inc. Methods and apparatus for perfusion of isolated tissue structure
AU2022999A (en) 1997-12-31 1999-07-19 Heartport, Inc. Methods and apparatus for perfusion of isolated tissue structure
US6146380A (en) 1998-01-09 2000-11-14 Radionics, Inc. Bent tip electrical surgical probe
ATE446122T1 (de) 1998-01-15 2009-11-15 Regenesis Biomedical Inc Verbesserte vorrichtung zur behandlung mittels pulsierter elektromagnetischer energie
US6251130B1 (en) 1998-03-24 2001-06-26 Innercool Therapies, Inc. Device for applications of selective organ cooling
US6522932B1 (en) 1998-02-10 2003-02-18 Advanced Bionics Corporation Implantable, expandable, multicontact electrodes and tools for use therewith
US6415187B1 (en) 1998-02-10 2002-07-02 Advanced Bionics Corporation Implantable, expandable, multicontact electrodes and insertion needle for use therewith
US6205361B1 (en) 1998-02-10 2001-03-20 Advanced Bionics Corporation Implantable expandable multicontact electrodes
US6645201B1 (en) * 1998-02-19 2003-11-11 Curon Medical, Inc. Systems and methods for treating dysfunctions in the intestines and rectum
US6273886B1 (en) 1998-02-19 2001-08-14 Curon Medical, Inc. Integrated tissue heating and cooling apparatus
US6258087B1 (en) 1998-02-19 2001-07-10 Curon Medical, Inc. Expandable electrode assemblies for forming lesions to treat dysfunction in sphincters and adjoining tissue regions
AU752243B2 (en) * 1998-02-19 2002-09-12 Curon Medical, Inc. Electrosurgical sphincter treatment apparatus
KR19990072499A (ko) 1998-02-19 1999-09-27 리페르트 존 유연성이높은부위를가지는카테테르안내와이어장치
US20020120252A1 (en) 1998-02-24 2002-08-29 Brock David L. Surgical instrument
US6949106B2 (en) 1998-02-24 2005-09-27 Endovia Medical, Inc. Surgical instrument
US6142993A (en) 1998-02-27 2000-11-07 Ep Technologies, Inc. Collapsible spline structure using a balloon as an expanding actuator
US5951471A (en) 1998-03-09 1999-09-14 Irvine Biomedical, Inc. Catheter-based coronary sinus mapping and ablation
US6308090B1 (en) 1998-03-09 2001-10-23 Irvine Biomedical, Inc. Devices and methods for coronary sinus mapping
US6132456A (en) 1998-03-10 2000-10-17 Medtronic, Inc. Arrangement for implanting an endocardial cardiac lead
US6078841A (en) 1998-03-27 2000-06-20 Advanced Bionics Corporation Flexible positioner for use with implantable cochlear electrode array
US6086527A (en) 1998-04-02 2000-07-11 Scimed Life Systems, Inc. System for treating congestive heart failure
US6071729A (en) 1998-04-02 2000-06-06 Jeffries; Thomas W. Disruption of the cytochrome C gene in xylose-fermenting yeast
US6314325B1 (en) 1998-04-07 2001-11-06 William R. Fitz Nerve hyperpolarization method and apparatus for pain relief
US6106518A (en) 1998-04-09 2000-08-22 Cryocath Technologies, Inc. Variable geometry tip for a cryosurgical ablation device
JP2002511292A (ja) 1998-04-13 2002-04-16 プロリフィックス メディカル， インコーポレイテッド 正確なカテーテル位置決めのためのガイドワイヤ
CA2326786A1 (en) 1998-04-14 1999-10-21 Charles L. Brown, Iii Iontophoresis, electroporation and combination catheters for local drug delivery to arteries and other body tissues
US6064902A (en) 1998-04-16 2000-05-16 C.R. Bard, Inc. Pulmonary vein ablation catheter
US5968085A (en) 1998-04-20 1999-10-19 Medtronic, Inc. Pacing lead with integral guidance using ultrasound
US5916154A (en) 1998-04-22 1999-06-29 Nellcor Puritan Bennett Method of enhancing performance in pulse oximetry via electrical stimulation
US20020065542A1 (en) 1998-04-22 2002-05-30 Ronald G. Lax Method and apparatus for treating an aneurysm
EP0951920B1 (de) 1998-04-22 2004-10-20 BIOTRONIK Mess- und Therapiegeräte GmbH & Co Ingenieurbüro Berlin Gefässelektrodenleitung
US6269269B1 (en) 1998-04-23 2001-07-31 Medtronic Inc. Method and apparatus for synchronized treatment of obstructive sleep apnea
US6058331A (en) 1998-04-27 2000-05-02 Medtronic, Inc. Apparatus and method for treating peripheral vascular disease and organ ischemia by electrical stimulation with closed loop feedback control
US6511492B1 (en) 1998-05-01 2003-01-28 Microvention, Inc. Embolectomy catheters and methods for treating stroke and other small vessel thromboembolic disorders
US5928272A (en) 1998-05-02 1999-07-27 Cyberonics, Inc. Automatic activation of a neurostimulator device using a detection algorithm based on cardiac activity
US6592581B2 (en) 1998-05-05 2003-07-15 Cardiac Pacemakers, Inc. Preformed steerable catheter with movable outer sleeve and method for use
US6192889B1 (en) 1998-05-05 2001-02-27 Woodside Biomedical, Inc. Method of suppression and prevention of the gag reflex
US6042580A (en) 1998-05-05 2000-03-28 Cardiac Pacemakers, Inc. Electrode having composition-matched, common-lead thermocouple wire for providing multiple temperature-sensitive junctions
US6146381A (en) 1998-05-05 2000-11-14 Cardiac Pacemakers, Inc. Catheter having distal region for deflecting axial forces
US6312425B1 (en) 1998-05-05 2001-11-06 Cardiac Pacemakers, Inc. RF ablation catheter tip electrode with multiple thermal sensors
US6049737A (en) 1998-05-05 2000-04-11 Cardiac Pacemakers, Inc. Catheter having common lead for electrode and sensor
US6074339A (en) 1998-05-07 2000-06-13 Medtronic Ave, Inc. Expandable braid device and method for radiation treatment
EP1079890A4 (en) 1998-05-08 2008-12-03 Genetronics Inc VASODILATION OF AN ELECTRICALLY INDUCED VESSEL
US6231572B1 (en) 1998-05-29 2001-05-15 Applied Medical Resources Corporation Electrosurgical catheter apparatus and method
US6623474B1 (en) 1998-06-04 2003-09-23 Biosense Webster, Inc. Injection catheter with needle stop
US7198635B2 (en) * 2000-10-17 2007-04-03 Asthmatx, Inc. Modification of airways by application of energy
US6368316B1 (en) 1998-06-11 2002-04-09 Target Therapeutics, Inc. Catheter with composite stiffener
WO1999065561A1 (en) 1998-06-19 1999-12-23 Cordis Webster, Inc. Method and apparatus for transvascular treatment of tachycardia and fibrillation
US6094596A (en) 1998-06-19 2000-07-25 Angeron Corporation Transvenous defibrillation lead system for use in middle cardiac vein
US6287306B1 (en) 1998-06-22 2001-09-11 Daig Corporation Even temperature linear lesion ablation catheter
US6066132A (en) 1998-06-30 2000-05-23 Ethicon, Inc. Articulating endometrial ablation device
US6322559B1 (en) 1998-07-06 2001-11-27 Vnus Medical Technologies, Inc. Electrode catheter having coil structure
US6302903B1 (en) 1998-07-07 2001-10-16 Medtronic, Inc. Straight needle apparatus for creating a virtual electrode used for the ablation of tissue
CA2337652C (en) 1998-07-13 2013-03-26 Genetronics, Inc. Skin and muscle-targeted gene therapy by pulsed electrical field
US6972013B1 (en) 1998-07-13 2005-12-06 Genetronics, Inc. Enhanced delivery of naked DNA to skin by non-invasive in vivo electroporation
US7599736B2 (en) 2001-07-23 2009-10-06 Dilorenzo Biomedical, Llc Method and apparatus for neuromodulation and physiologic modulation for the treatment of metabolic and neuropsychiatric disease
US6179860B1 (en) 1998-08-19 2001-01-30 Artemis Medical, Inc. Target tissue localization device and method
US6610083B2 (en) 1998-08-24 2003-08-26 Radiant Medical, Inc. Multiple lumen heat exchange catheters
US6304787B1 (en) 1998-08-26 2001-10-16 Advanced Bionics Corporation Cochlear electrode array having current-focusing and tissue-treating features
US6228109B1 (en) 1998-08-31 2001-05-08 Lily Chen Tu Methods for treating atherosclerosis and vulnerable plaques
US6123702A (en) 1998-09-10 2000-09-26 Scimed Life Systems, Inc. Systems and methods for controlling power in an electrosurgical probe
US6385472B1 (en) 1999-09-10 2002-05-07 Stereotaxis, Inc. Magnetically navigable telescoping catheter and method of navigating telescoping catheter
US6319251B1 (en) * 1998-09-24 2001-11-20 Hosheng Tu Medical device and methods for treating intravascular restenosis
US6544215B1 (en) 1998-10-02 2003-04-08 Scimed Life Systems, Inc. Steerable device for introducing diagnostic and therapeutic apparatus into the body
US6123718A (en) 1998-11-02 2000-09-26 Polymerex Medical Corp. Balloon catheter
US6701176B1 (en) 1998-11-04 2004-03-02 Johns Hopkins University School Of Medicine Magnetic-resonance-guided imaging, electrophysiology, and ablation
US6083156A (en) * 1998-11-16 2000-07-04 Ronald S. Lisiecki Portable integrated physiological monitoring system
US7313444B2 (en) 1998-11-20 2007-12-25 Pacesetter, Inc. Self-anchoring coronary sinus lead
US6638278B2 (en) 1998-11-23 2003-10-28 C. R. Bard, Inc. Intracardiac grasp catheter
US6319250B1 (en) 1998-11-23 2001-11-20 C.R. Bard, Inc Tricuspid annular grasp catheter
EP1140278B1 (en) 1998-12-14 2004-05-19 Tre Esse Progettazione Biomedica S.r.l Catheter system for performing intramyocardiac therapeutic treatment
US20070066972A1 (en) 2001-11-29 2007-03-22 Medwaves, Inc. Ablation catheter apparatus with one or more electrodes
US6077227A (en) 1998-12-28 2000-06-20 Medtronic, Inc. Method for manufacture and implant of an implantable blood vessel cuff
US6749598B1 (en) 1999-01-11 2004-06-15 Flowmedica, Inc. Apparatus and methods for treating congestive heart disease
US7329236B2 (en) 1999-01-11 2008-02-12 Flowmedica, Inc. Intra-aortic renal drug delivery catheter
US7122019B1 (en) 2000-11-28 2006-10-17 Flowmedica Inc. Intra-aortic renal drug delivery catheter
US7780628B1 (en) 1999-01-11 2010-08-24 Angiodynamics, Inc. Apparatus and methods for treating congestive heart disease
US7481803B2 (en) 2000-11-28 2009-01-27 Flowmedica, Inc. Intra-aortic renal drug delivery catheter
CA2368707C (en) 1999-02-02 2006-06-06 Transurgical, Inc. Intrabody hifu applicator
US6210408B1 (en) 1999-02-24 2001-04-03 Scimed Life Systems, Inc. Guide wire system for RF recanalization of vascular blockages
US6210339B1 (en) 1999-03-03 2001-04-03 Endosonics Corporation Flexible elongate member having one or more electrical contacts
US6508774B1 (en) 1999-03-09 2003-01-21 Transurgical, Inc. Hifu applications with feedback control
US6464687B1 (en) 1999-03-09 2002-10-15 Ball Semiconductor, Inc. Implantable drug delivery system
JP4102031B2 (ja) 1999-03-09 2008-06-18 サーメイジ インコーポレイテッド 組織を治療するのための装置および方法
US6136021A (en) * 1999-03-23 2000-10-24 Cardiac Pacemakers, Inc. Expandable electrode for coronary venous leads
US6129750A (en) 1999-03-23 2000-10-10 Cardiac Pacemakers, Inc. Fixation mechanism for a coronary venous pacing lead
US6678558B1 (en) 1999-03-25 2004-01-13 Genetronics, Inc. Method and apparatus for reducing electroporation-mediated muscle reaction and pain response
US6161049A (en) 1999-03-26 2000-12-12 Urologix, Inc. Thermal therapy catheter
US6325797B1 (en) 1999-04-05 2001-12-04 Medtronic, Inc. Ablation catheter and method for isolating a pulmonary vein
US20050010095A1 (en) 1999-04-05 2005-01-13 Medtronic, Inc. Multi-purpose catheter apparatus and method of use
US20010007070A1 (en) 1999-04-05 2001-07-05 Medtronic, Inc. Ablation catheter assembly and method for isolating a pulmonary vein
US6702811B2 (en) * 1999-04-05 2004-03-09 Medtronic, Inc. Ablation catheter assembly with radially decreasing helix and method of use
US6366808B1 (en) 2000-03-13 2002-04-02 Edward A. Schroeppel Implantable device and method for the electrical treatment of cancer
US6738663B2 (en) 1999-04-09 2004-05-18 Oncostim, A Minnesota Corporation Implantable device and method for the electrical treatment of cancer
US20040044350A1 (en) 1999-04-09 2004-03-04 Evalve, Inc. Steerable access sheath and methods of use
US6178349B1 (en) 1999-04-15 2001-01-23 Medtronic, Inc. Drug delivery neural stimulation device for treatment of cardiovascular disorders
US6317615B1 (en) 1999-04-19 2001-11-13 Cardiac Pacemakers, Inc. Method and system for reducing arterial restenosis in the presence of an intravascular stent
US6939346B2 (en) 1999-04-21 2005-09-06 Oratec Interventions, Inc. Method and apparatus for controlling a temperature-controlled probe
US6923784B2 (en) 1999-04-30 2005-08-02 Medtronic, Inc. Therapeutic treatment of disorders based on timing information
CA2336416A1 (en) 1999-04-30 2000-11-09 Gono Usami Catheter and guide wire
US6341236B1 (en) 1999-04-30 2002-01-22 Ivan Osorio Vagal nerve stimulation techniques for treatment of epileptic seizures
AU4696100A (en) 1999-05-04 2000-11-17 Curon Medical, Inc. Electrodes for creating lesions in tissue regions at or near a sphincter
US6178352B1 (en) 1999-05-07 2001-01-23 Woodside Biomedical, Inc. Method of blood pressure moderation
ES2279757T3 (es) 1999-05-11 2007-09-01 Atrionix, Inc. Hilo de anclaje de balon.
US6758830B1 (en) 1999-05-11 2004-07-06 Atrionix, Inc. Catheter positioning system
US6692490B1 (en) * 1999-05-18 2004-02-17 Novasys Medical, Inc. Treatment of urinary incontinence and other disorders by application of energy and drugs
US7343195B2 (en) 1999-05-18 2008-03-11 Mediguide Ltd. Method and apparatus for real time quantitative three-dimensional image reconstruction of a moving organ and intra-body navigation
DE29909082U1 (de) 1999-05-25 1999-07-22 Starck Stimulations-, Sensing- und/oder Defibrillationselektrode sowie Ballon-Katheter zum Einbringen der Elektrode
US6304777B1 (en) 1999-05-26 2001-10-16 Impulse Dynamics N.V. Induction of cardioplegia applied electrical signals
US6442424B1 (en) 1999-05-26 2002-08-27 Impulse Dynamics N.V. Local cardiac motion control using applied electrical signals
US7171263B2 (en) * 1999-06-04 2007-01-30 Impulse Dynamics Nv Drug delivery device
US6890329B2 (en) 1999-06-15 2005-05-10 Cryocath Technologies Inc. Defined deflection structure
US6546272B1 (en) 1999-06-24 2003-04-08 Mackinnon Nicholas B. Apparatus for in vivo imaging of the respiratory tract and other internal organs
JP2003503119A (ja) * 1999-06-25 2003-01-28 エモリ ユニバーシティ 迷走神経刺激用機器及び方法
US6272383B1 (en) 1999-06-28 2001-08-07 Woodside Biomedical, Inc. Electro-acupuncture method using an electrical stimulator
US6620172B1 (en) 1999-07-01 2003-09-16 Medsource Technologies, Inc. Entraining biological calculi
US6364904B1 (en) 1999-07-02 2002-04-02 Scimed Life Systems, Inc. Helically formed stent/graft assembly
US6605061B2 (en) 1999-07-14 2003-08-12 Tricardia, L.L.C. Catheter for drug injection in cardiovascular system
US6927049B2 (en) 1999-07-21 2005-08-09 The Regents Of The University Of California Cell viability detection using electrical measurements
US6300108B1 (en) 1999-07-21 2001-10-09 The Regents Of The University Of California Controlled electroporation and mass transfer across cell membranes
US7053063B2 (en) 1999-07-21 2006-05-30 The Regents Of The University Of California Controlled electroporation and mass transfer across cell membranes in tissue
US6508804B2 (en) 1999-07-28 2003-01-21 Scimed Life Systems, Inc. Catheter having continuous lattice and coil reinforcement
US6326177B1 (en) 1999-08-04 2001-12-04 Eastern Virginia Medical School Of The Medical College Of Hampton Roads Method and apparatus for intracellular electro-manipulation
FR2797389B1 (fr) 1999-08-09 2001-11-30 Novatech Inc Prothese aortique bifurquee
US6767544B2 (en) 2002-04-01 2004-07-27 Allergan, Inc. Methods for treating cardiovascular diseases with botulinum toxin
US6442415B1 (en) 1999-08-12 2002-08-27 Magnetic Moments, L.L.C. Contrast-enhanced coronary artery and coronary artery bypass graft imaging using an aortic root catheter injection with either magnetic resonance angiography or computed tomographic angiography
US7171275B2 (en) 1999-08-12 2007-01-30 Irvine Biomedical Inc. High torque balloon catheter possessing multi-directional deflectability and methods thereof
US6611720B2 (en) 1999-08-12 2003-08-26 Irvine Biomedical Inc. High torque catheter possessing multi-directional deflectability and methods thereof
US6246914B1 (en) 1999-08-12 2001-06-12 Irvine Biomedical, Inc. High torque catheter and methods thereof
US6450942B1 (en) 1999-08-20 2002-09-17 Cardiorest International Ltd. Method for reducing heart loads in mammals
US6575966B2 (en) * 1999-08-23 2003-06-10 Cryocath Technologies Inc. Endovascular cryotreatment catheter
EP1229820A4 (en) 1999-09-10 2008-07-23 Prorhythm Inc CLOSURE OF TUBULAR, ANATOMICAL STRUCTURES THROUGH ENERGY INPUT
US6607520B2 (en) 1999-09-15 2003-08-19 The General Hospital Corporation Coiled ablation catheter system
US6632223B1 (en) * 2000-03-30 2003-10-14 The General Hospital Corporation Pulmonary vein ablation stent and method
US6454775B1 (en) 1999-12-06 2002-09-24 Bacchus Vascular Inc. Systems and methods for clot disruption and retrieval
US7510536B2 (en) 1999-09-17 2009-03-31 University Of Washington Ultrasound guided high intensity focused ultrasound treatment of nerves
AU7735200A (en) * 1999-09-28 2001-04-30 Novasys Medical, Inc. Treatment of tissue by application of energy and drugs
US6272377B1 (en) 1999-10-01 2001-08-07 Cardiac Pacemakers, Inc. Cardiac rhythm management system with arrhythmia prediction and prevention
US6473644B1 (en) 1999-10-13 2002-10-29 Cyberonics, Inc. Method to enhance cardiac capillary growth in heart failure patients
US6287304B1 (en) 1999-10-15 2001-09-11 Neothermia Corporation Interstitial cauterization of tissue volumes with electrosurgically deployed electrodes
US6669655B1 (en) 1999-10-20 2003-12-30 Transurgical, Inc. Sonic element and catheter incorporating same
EP1224436A1 (en) 1999-10-29 2002-07-24 Universität Zürich Method of volumetric blood flow measurement
US6436091B1 (en) 1999-11-16 2002-08-20 Microsolutions, Inc. Methods and implantable devices and systems for long term delivery of a pharmaceutical agent
US6529756B1 (en) 1999-11-22 2003-03-04 Scimed Life Systems, Inc. Apparatus for mapping and coagulating soft tissue in or around body orifices
US6542781B1 (en) * 1999-11-22 2003-04-01 Scimed Life Systems, Inc. Loop structures for supporting diagnostic and therapeutic elements in contact with body tissue
US6745080B2 (en) 1999-11-22 2004-06-01 Scimed Life Systems, Inc. Helical and pre-oriented loop structures for supporting diagnostic and therapeutic elements in contact with body tissue
WO2001037723A2 (en) * 1999-11-22 2001-05-31 Boston Scientific Limited Loop structures for supporting diagnostic and therapeutic elements in contact with body tissue
US6613046B1 (en) * 1999-11-22 2003-09-02 Scimed Life Systems, Inc. Loop structures for supporting diagnostic and therapeutic elements in contact with body tissue
US6711444B2 (en) 1999-11-22 2004-03-23 Scimed Life Systems, Inc. Methods of deploying helical diagnostic and therapeutic element supporting structures within the body
ATE365574T1 (de) 1999-11-30 2007-07-15 Biotronik Gmbh & Co Kg Gerät zur regelung der herzfrequenz und der herzpumpkraft
US20020026228A1 (en) 1999-11-30 2002-02-28 Patrick Schauerte Electrode for intravascular stimulation, cardioversion and/or defibrillation
US6575932B1 (en) * 1999-12-02 2003-06-10 Ottawa Heart Institute Adjustable multi-balloon local delivery device
US6280466B1 (en) 1999-12-03 2001-08-28 Teramed Inc. Endovascular graft system
US6592567B1 (en) 1999-12-07 2003-07-15 Chf Solutions, Inc. Kidney perfusion catheter
US6415183B1 (en) 1999-12-09 2002-07-02 Cardiac Pacemakers, Inc. Method and apparatus for diaphragmatic pacing
US20030150464A1 (en) 1999-12-17 2003-08-14 Casscells S. Ward Inducing apoptosis of atrial myocytes to treat atrial fibrillation
US7896872B2 (en) 1999-12-21 2011-03-01 Philip Michael Finch Apparatus for thermal treatment of an intervertebral disc
DE10042330A1 (de) 1999-12-22 2002-03-14 Hans Sachse Dünndarmsonde, wandverstärkt
US6328699B1 (en) 2000-01-11 2001-12-11 Cedars-Sinai Medical Center Permanently implantable system and method for detecting, diagnosing and treating congestive heart failure
US6356787B1 (en) 2000-02-24 2002-03-12 Electro Core Techniques, Llc Method of treating facial blushing by electrical stimulation of the sympathetic nerve chain
US6356786B1 (en) 2000-01-20 2002-03-12 Electrocore Techniques, Llc Method of treating palmar hyperhydrosis by electrical stimulation of the sympathetic nervous chain
US6885888B2 (en) 2000-01-20 2005-04-26 The Cleveland Clinic Foundation Electrical stimulation of the sympathetic nerve chain
US20060085046A1 (en) 2000-01-20 2006-04-20 Ali Rezai Methods of treating medical conditions by transvascular neuromodulation of the autonomic nervous system
US6438423B1 (en) 2000-01-20 2002-08-20 Electrocore Technique, Llc Method of treating complex regional pain syndromes by electrical stimulation of the sympathetic nerve chain
US7184827B1 (en) * 2000-01-24 2007-02-27 Stuart D. Edwards Shrinkage of dilatations in the body
WO2001055212A2 (en) 2000-01-27 2001-08-02 The General Hospital Corporation Delivery of therapeutic biological from implantable tissue matrices
US6628976B1 (en) 2000-01-27 2003-09-30 Biosense Webster, Inc. Catheter having mapping assembly
US6514226B1 (en) 2000-02-10 2003-02-04 Chf Solutions, Inc. Method and apparatus for treatment of congestive heart failure by improving perfusion of the kidney
US6540734B1 (en) 2000-02-16 2003-04-01 Advanced Cardiovascular Systems, Inc. Multi-lumen extrusion tubing
US6868289B2 (en) 2002-10-02 2005-03-15 Standen Ltd. Apparatus for treating a tumor or the like and articles incorporating the apparatus for treatment of the tumor
US7565205B2 (en) 2000-02-17 2009-07-21 Standen Ltd. Treating a tumor or the like with electric fields at different orientations
US6536949B1 (en) 2000-03-07 2003-03-25 Richard R. Heuser Catheter for thermal evaluation of arteriosclerotic plaque
US6770070B1 (en) 2000-03-17 2004-08-03 Rita Medical Systems, Inc. Lung treatment apparatus and method
US6554774B1 (en) * 2000-03-23 2003-04-29 Tensys Medical, Inc. Method and apparatus for assessing hemodynamic properties within the circulatory system of a living subject
WO2001072373A2 (en) 2000-03-24 2001-10-04 Transurgical, Inc. Apparatus and method for intrabody thermal treatment
US20010031981A1 (en) 2000-03-31 2001-10-18 Evans Michael A. Method and device for locating guidewire and treating chronic total occlusions
US6287608B1 (en) 2000-04-11 2001-09-11 Intellicardia, Inc. Method and apparatus for treatment of congestive heart failure by improving perfusion of the kidney by infusion of a vasodilator
US6652517B1 (en) 2000-04-25 2003-11-25 Uab Research Foundation Ablation catheter, system, and method of use thereof
US20010044596A1 (en) 2000-05-10 2001-11-22 Ali Jaafar Apparatus and method for treatment of vascular restenosis by electroporation
US6936047B2 (en) 2000-05-12 2005-08-30 Agility Capital Llc Multi-channel RF energy delivery with coagulum reduction
US6306423B1 (en) 2000-06-02 2001-10-23 Allergan Sales, Inc. Neurotoxin implant
AU6682401A (en) 2000-06-13 2001-12-24 Atrionix Inc Surgical ablation probe for forming a circumferential lesion
US6546270B1 (en) 2000-07-07 2003-04-08 Biosense, Inc. Multi-electrode catheter, system and method
US6405067B1 (en) 2000-07-07 2002-06-11 Biosense Webster, Inc. Catheter with tip electrode having a recessed ring electrode mounted thereon
EP2275174B1 (en) 2000-07-13 2016-04-20 ReCor Medical, Inc. Thermal treatment apparatus with ultrasound energy application
EP1303332B1 (en) 2000-07-26 2004-12-29 Advanced Bionics Corporation Rechargeable spinal cord stimulator system
US6795728B2 (en) 2001-08-17 2004-09-21 Minnesota Medical Physics, Llc Apparatus and method for reducing subcutaneous fat deposits by electroporation
US6892099B2 (en) 2001-02-08 2005-05-10 Minnesota Medical Physics, Llc Apparatus and method for reducing subcutaneous fat deposits, virtual face lift and body sculpturing by electroporation
US6697670B2 (en) 2001-08-17 2004-02-24 Minnesota Medical Physics, Llc Apparatus and method for reducing subcutaneous fat deposits by electroporation with improved comfort of patients
US6862479B1 (en) 2000-08-30 2005-03-01 Advanced Bionics Corporation Spinal cord stimulation as a therapy for sexual dysfunction
US6584362B1 (en) * 2000-08-30 2003-06-24 Cardiac Pacemakers, Inc. Leads for pacing and/or sensing the heart from within the coronary veins
WO2002019933A1 (en) 2000-09-07 2002-03-14 Sherwood Services Ag Apparatus for and treatment of the intervertebral disc
US6405079B1 (en) 2000-09-22 2002-06-11 Mehdi M. Ansarinia Stimulation method for the dural venous sinuses and adjacent dura for treatment of medical conditions
US7158832B2 (en) 2000-09-27 2007-01-02 Cvrx, Inc. Electrode designs and methods of use for cardiovascular reflex control devices
US7623926B2 (en) 2000-09-27 2009-11-24 Cvrx, Inc. Stimulus regimens for cardiovascular reflex control
US6985774B2 (en) 2000-09-27 2006-01-10 Cvrx, Inc. Stimulus regimens for cardiovascular reflex control
US7499742B2 (en) 2001-09-26 2009-03-03 Cvrx, Inc. Electrode structures and methods for their use in cardiovascular reflex control
US7616997B2 (en) 2000-09-27 2009-11-10 Kieval Robert S Devices and methods for cardiovascular reflex control via coupled electrodes
US7840271B2 (en) 2000-09-27 2010-11-23 Cvrx, Inc. Stimulus regimens for cardiovascular reflex control
US6850801B2 (en) 2001-09-26 2005-02-01 Cvrx, Inc. Mapping methods for cardiovascular reflex control devices
US6522926B1 (en) 2000-09-27 2003-02-18 Cvrx, Inc. Devices and methods for cardiovascular reflex control
US7090648B2 (en) * 2000-09-28 2006-08-15 Non-Invasive Monitoring Systems, Inc. External addition of pulses to fluid channels of body to release or suppress endothelial mediators and to determine effectiveness of such intervention
US6845267B2 (en) 2000-09-28 2005-01-18 Advanced Bionics Corporation Systems and methods for modulation of circulatory perfusion by electrical and/or drug stimulation
US7306591B2 (en) 2000-10-02 2007-12-11 Novasys Medical, Inc. Apparatus and methods for treating female urinary incontinence
US6640120B1 (en) 2000-10-05 2003-10-28 Scimed Life Systems, Inc. Probe assembly for mapping and ablating pulmonary vein tissue and method of using same
US6926669B1 (en) 2000-10-10 2005-08-09 Medtronic, Inc. Heart wall ablation/mapping catheter and method
US6802857B1 (en) 2000-10-11 2004-10-12 Uab Research Foundation MRI stent
US7104987B2 (en) 2000-10-17 2006-09-12 Asthmatx, Inc. Control system and process for application of energy to airway walls and other mediums
US7646544B2 (en) 2005-05-14 2010-01-12 Batchko Robert G Fluidic optical devices
DE60134878D1 (de) 2000-10-26 2008-08-28 Medtronic Inc Vorrichtung zur elektrischen stimulation des nervensystems zur therapie ventrikulärer fehlfunktionen, herzversagen und anderer kardialer zustände
WO2002034330A2 (en) 2000-10-26 2002-05-02 Medtronic, Inc. Method and apparatus to minimize the effects of a cardiac insult
EP1201198A1 (en) 2000-10-27 2002-05-02 MicroNet Medical, Inc. Catheter with thin film electrodes and method for making same
US6616624B1 (en) 2000-10-30 2003-09-09 Cvrx, Inc. Systems and method for controlling renovascular perfusion
US6942692B2 (en) 2000-11-16 2005-09-13 Cordis Corporation Supra-renal prosthesis and renal artery bypass
US6579308B1 (en) 2000-11-28 2003-06-17 Scimed Life Systems, Inc. Stent devices with detachable distal or proximal wires
US6728563B2 (en) 2000-11-29 2004-04-27 St. Jude Medical, Daig Division, Inc. Electrophysiology/ablation catheter having “halo” configuration
US7081114B2 (en) 2000-11-29 2006-07-25 St. Jude Medical, Atrial Fibrillation Division, Inc. Electrophysiology/ablation catheter having lariat configuration of variable radius
US6681136B2 (en) 2000-12-04 2004-01-20 Science Medicus, Inc. Device and method to modulate blood pressure by electrical waveforms
US6676657B2 (en) 2000-12-07 2004-01-13 The United States Of America As Represented By The Department Of Health And Human Services Endoluminal radiofrequency cauterization system
US6772015B2 (en) * 2000-12-29 2004-08-03 Medtronic, Inc Bifurcated lead system for a cardiac vein
US6527739B1 (en) 2000-12-29 2003-03-04 Advanced Cardiovascular Systems, Inc. Spiraled balloon arrangement for treatment of a tortuous vessel
US20020087151A1 (en) 2000-12-29 2002-07-04 Afx, Inc. Tissue ablation apparatus with a sliding ablation instrument and method
WO2002053207A2 (en) 2001-01-04 2002-07-11 Advanced Neuromodulation Systems, Inc. Implantable infusion pump
US6666845B2 (en) 2001-01-04 2003-12-23 Advanced Neuromodulation Systems, Inc. Implantable infusion pump
US6622731B2 (en) 2001-01-11 2003-09-23 Rita Medical Systems, Inc. Bone-treatment instrument and method
US6480747B2 (en) 2001-01-16 2002-11-12 Quetzal Biomedical, Inc. Cardiac electrode catheter and method of manufacturing same
US6602241B2 (en) * 2001-01-17 2003-08-05 Transvascular, Inc. Methods and apparatus for acute or chronic delivery of substances or apparatus to extravascular treatment sites
ATE387167T1 (de) 2001-01-19 2008-03-15 Boston Scient Ltd Vorrichtung zum einbringen einer abzweigenden prothese
US6600954B2 (en) 2001-01-25 2003-07-29 Biocontrol Medical Bcm Ltd. Method and apparatus for selective control of nerve fibers
US6672312B2 (en) 2001-01-31 2004-01-06 Transurgical, Inc. Pulmonary vein ablation with myocardial tissue locating
US6451045B1 (en) 2001-02-22 2002-09-17 Alsius Corporation Heat exchange catheter having a helically wrapped heat exchanger
US6564096B2 (en) 2001-02-28 2003-05-13 Robert A. Mest Method and system for treatment of tachycardia and fibrillation
US6620151B2 (en) 2001-03-01 2003-09-16 Advanced Neuromodulation Systems, Inc. Non-constant pressure infusion pump
AU2002250250A1 (en) * 2001-03-01 2002-09-19 Three Arch Partners Intravascular device for treatment of hypertension
WO2002069821A1 (en) 2001-03-06 2002-09-12 Thermemed Corp. Vaporous delivery of thermal energy to tissue sites
US6786904B2 (en) 2002-01-10 2004-09-07 Triton Biosystems, Inc. Method and device to treat vulnerable plaque
DE10114725A1 (de) 2001-03-21 2002-09-26 Biotronik Mess & Therapieg Intravaskuläre Elektrodenleitung
WO2002076344A1 (en) 2001-03-23 2002-10-03 Durect Corporation Delivery of drugs from sustained release devices implanted in myocardial tissue or in the pericardial space
EP1395330A1 (en) 2001-04-20 2004-03-10 The Board of Regents for the University of Oklahoma Cardiac neuromodulation and methods of using same
WO2002085192A2 (en) 2001-04-23 2002-10-31 Transurgical, Inc. Improvements in ablation therapy
US7959626B2 (en) 2001-04-26 2011-06-14 Medtronic, Inc. Transmural ablation systems and methods
US6663627B2 (en) 2001-04-26 2003-12-16 Medtronic, Inc. Ablation system and method of use
US6684105B2 (en) 2001-08-31 2004-01-27 Biocontrol Medical, Ltd. Treatment of disorders by unidirectional nerve stimulation
US6909920B2 (en) * 2001-04-27 2005-06-21 Medtronic, Inc. System and method for positioning an implantable medical device within a body
WO2002087676A2 (en) 2001-04-27 2002-11-07 C.R. Bard, Inc. Electrophysiology catheter for mapping and/or ablation
US6972016B2 (en) * 2001-05-01 2005-12-06 Cardima, Inc. Helically shaped electrophysiology catheter
US20020169444A1 (en) 2001-05-08 2002-11-14 Mest Robert A. Catheter having continuous braided electrode
WO2002089908A1 (en) 2001-05-10 2002-11-14 Super Dimension Ltd. Steerable multiple electrode catheter and method
WO2002089686A1 (en) 2001-05-10 2002-11-14 Rita Medical Systems, Inc. Rf tissue ablation apparatus and method
US6716207B2 (en) 2001-05-22 2004-04-06 Scimed Life Systems, Inc. Torqueable and deflectable medical device shaft
US6771996B2 (en) 2001-05-24 2004-08-03 Cardiac Pacemakers, Inc. Ablation and high-resolution mapping catheter system for pulmonary vein foci elimination
WO2002096512A1 (en) 2001-05-29 2002-12-05 Medtronic, Inc. Closed-loop neuromodulation for prevention and treatment of cardiac conditions
US7674245B2 (en) 2001-06-07 2010-03-09 Cardiac Pacemakers, Inc. Method and apparatus for an adjustable shape guide catheter
US7127284B2 (en) 2001-06-11 2006-10-24 Mercator Medsystems, Inc. Electroporation microneedle and methods for its use
FR2827548A1 (fr) 2001-07-17 2003-01-24 Michelin Soc Tech Ensemble monte tubeless pour cycle, jante et pneumatique tubeless
US20060167498A1 (en) 2001-07-23 2006-07-27 Dilorenzo Daniel J Method, apparatus, and surgical technique for autonomic neuromodulation for the treatment of disease
WO2003011388A2 (de) 2001-07-27 2003-02-13 Impella Cardiotechnik Ag Neurostimulationseinheit zur immobilisation des herzens während kardiochirurgischer operationen
US6994706B2 (en) 2001-08-13 2006-02-07 Minnesota Medical Physics, Llc Apparatus and method for treatment of benign prostatic hyperplasia
US6600956B2 (en) 2001-08-21 2003-07-29 Cyberonics, Inc. Circumneural electrode assembly
US6622041B2 (en) 2001-08-21 2003-09-16 Cyberonics, Inc. Treatment of congestive heart failure and autonomic cardiovascular drive disorders
US20030050635A1 (en) 2001-08-22 2003-03-13 Csaba Truckai Embolization systems and techniques for treating tumors
WO2003020138A1 (en) 2001-08-31 2003-03-13 Scimed Life Systems, Inc. Percutaneous pringle occlusion device
WO2003020915A2 (en) 2001-08-31 2003-03-13 Cyto Pulse Sciences, Inc. Non-linear amplitude dielectrophoresis waveform for cell fusion
US7778703B2 (en) 2001-08-31 2010-08-17 Bio Control Medical (B.C.M.) Ltd. Selective nerve fiber stimulation for treating heart conditions
US7252679B2 (en) 2001-09-13 2007-08-07 Cordis Corporation Stent with angulated struts
EP1429676A4 (en) 2001-09-19 2007-10-24 Urologix Inc MICROWAVE FREQUENCY ABLATION DEVICE
US7547294B2 (en) 2001-09-20 2009-06-16 The Regents Of The University Of California Microfabricated surgical device for interventional procedures
US6547803B2 (en) 2001-09-20 2003-04-15 The Regents Of The University Of California Microfabricated surgical device for interventional procedures
JP3607231B2 (ja) 2001-09-28 2005-01-05 有限会社日本エレクテル 高周波加温バルーンカテーテル
EP1434621A2 (en) 2001-10-01 2004-07-07 AM Discovery, Incorporated Devices for treating atrial fibrilation
NL1019161C2 (nl) 2001-10-11 2003-04-14 Itsac Nv Kunststof spout.
US8974446B2 (en) 2001-10-11 2015-03-10 St. Jude Medical, Inc. Ultrasound ablation apparatus with discrete staggered ablation zones
US20030078618A1 (en) * 2001-10-19 2003-04-24 Fey Kate E. System and method for removing implanted devices
US20030082225A1 (en) 2001-10-19 2003-05-01 Mason Paul Arthur Sterile, breathable patch for treating wound pain
US6829508B2 (en) * 2001-10-19 2004-12-07 Alfred E. Mann Foundation For Scientific Research Electrically sensing and stimulating system for placement of a nerve stimulator or sensor
US6926716B2 (en) 2001-11-09 2005-08-09 Surgrx Inc. Electrosurgical instrument
US7517349B2 (en) 2001-10-22 2009-04-14 Vnus Medical Technologies, Inc. Electrosurgical instrument and method
AUPR847201A0 (en) 2001-10-26 2001-11-15 Cook Incorporated Endoluminal graft
CA2468531C (en) 2001-11-29 2010-06-01 Medwaves, Inc. Radio-frequency-based catheter system with improved deflection and steering mechanisms
US7488313B2 (en) 2001-11-29 2009-02-10 Boston Scientific Scimed, Inc. Mechanical apparatus and method for dilating and delivering a therapeutic agent to a site of treatment
DE60209799T2 (de) 2001-12-03 2007-01-25 Ekos Corp., Bothell Katheter mit mehreren ultraschall-abstrahlenden teilen
US6748255B2 (en) 2001-12-14 2004-06-08 Biosense Webster, Inc. Basket catheter with multiple location sensors
US20030125790A1 (en) 2001-12-27 2003-07-03 Vitaly Fastovsky Deployment device, system and method for medical implantation
US6980858B2 (en) * 2001-12-31 2005-12-27 Biosense Webster, Inc. Method and system for atrial defibrillation
US6817999B2 (en) 2002-01-03 2004-11-16 Afx, Inc. Flexible device for ablation of biological tissue
US6893436B2 (en) 2002-01-03 2005-05-17 Afx, Inc. Ablation instrument having a flexible distal portion
AU2003209287A1 (en) 2002-01-15 2003-07-30 The Regents Of The University Of California System and method providing directional ultrasound therapy to skeletal joints
US20060189941A1 (en) 2002-01-22 2006-08-24 Mercator Medsystems, Inc. Methods and kits for volumetric distribution of pharmaceutical agents via the vascular adventitia and microcirculation
US7819826B2 (en) 2002-01-23 2010-10-26 The Regents Of The University Of California Implantable thermal treatment method and apparatus
US7155284B1 (en) 2002-01-24 2006-12-26 Advanced Bionics Corporation Treatment of hypertension
US7967816B2 (en) 2002-01-25 2011-06-28 Medtronic, Inc. Fluid-assisted electrosurgical instrument with shapeable electrode
US6814733B2 (en) 2002-01-31 2004-11-09 Biosense, Inc. Radio frequency pulmonary vein isolation
US7477945B2 (en) 2002-02-01 2009-01-13 The Cleveland Clinic Foundation Delivery device for stimulating the sympathetic nerve chain
CA2474926A1 (en) 2002-02-01 2003-08-14 Ali Rezai Neural stimulation delivery device with independently moveable delivery structures
AU2003212870A1 (en) 2002-02-01 2003-09-02 The Cleveland Clinic Foundation Methods of affecting hypothalamic-related conditions
US7311705B2 (en) 2002-02-05 2007-12-25 Medtronic, Inc. Catheter apparatus for treatment of heart arrhythmia
US6949121B1 (en) 2002-02-07 2005-09-27 Sentient Engineering & Technology, Llc Apparatus and methods for conduits and materials
US8133501B2 (en) 2002-02-08 2012-03-13 Boston Scientific Scimed, Inc. Implantable or insertable medical devices for controlled drug delivery
US20040073117A1 (en) 2002-02-14 2004-04-15 Schwarz Karl Q. Method and system for delivering contrast agent
US7236821B2 (en) * 2002-02-19 2007-06-26 Cardiac Pacemakers, Inc. Chronically-implanted device for sensing and therapy
US6733499B2 (en) 2002-02-28 2004-05-11 Biosense Webster, Inc. Catheter having circular ablation assembly
JP2005519680A (ja) 2002-03-14 2005-07-07 ブレインズゲート リミティド 血圧制御技術
US6882885B2 (en) 2002-03-19 2005-04-19 Solarant Medical, Inc. Heating method for tissue contraction
ITBS20020039U1 (it) 2002-03-20 2003-09-22 Fogazzi Di Venturelli Andrea & Catetere con elettrodo flessibile raffreddato
US6736835B2 (en) * 2002-03-21 2004-05-18 Depuy Acromed, Inc. Early intervention spinal treatment methods and devices for use therein
EP3505143B1 (en) 2002-03-22 2022-12-14 Cardinal Health Switzerland 515 GmbH Rapid exchange balloon catheter shaft
JP4295627B2 (ja) 2002-03-27 2009-07-15 シーブイアールエックス， インコーポレイテッド 電極構造体および循環系反射の制御におけるその使用方法
US8774913B2 (en) * 2002-04-08 2014-07-08 Medtronic Ardian Luxembourg S.A.R.L. Methods and apparatus for intravasculary-induced neuromodulation
US7620451B2 (en) * 2005-12-29 2009-11-17 Ardian, Inc. Methods and apparatus for pulsed electric field neuromodulation via an intra-to-extravascular approach
US7853333B2 (en) 2002-04-08 2010-12-14 Ardian, Inc. Methods and apparatus for multi-vessel renal neuromodulation
US8347891B2 (en) 2002-04-08 2013-01-08 Medtronic Ardian Luxembourg S.A.R.L. Methods and apparatus for performing a non-continuous circumferential treatment of a body lumen
US8150519B2 (en) * 2002-04-08 2012-04-03 Ardian, Inc. Methods and apparatus for bilateral renal neuromodulation
US20070135875A1 (en) * 2002-04-08 2007-06-14 Ardian, Inc. Methods and apparatus for thermally-induced renal neuromodulation
US7162303B2 (en) 2002-04-08 2007-01-09 Ardian, Inc. Renal nerve stimulation method and apparatus for treatment of patients
US8131371B2 (en) 2002-04-08 2012-03-06 Ardian, Inc. Methods and apparatus for monopolar renal neuromodulation
US8145316B2 (en) * 2002-04-08 2012-03-27 Ardian, Inc. Methods and apparatus for renal neuromodulation
US8150520B2 (en) * 2002-04-08 2012-04-03 Ardian, Inc. Methods for catheter-based renal denervation
US8145317B2 (en) * 2002-04-08 2012-03-27 Ardian, Inc. Methods for renal neuromodulation
US6978174B2 (en) 2002-04-08 2005-12-20 Ardian, Inc. Methods and devices for renal nerve blocking
US20080213331A1 (en) * 2002-04-08 2008-09-04 Ardian, Inc. Methods and devices for renal nerve blocking
US7617005B2 (en) 2002-04-08 2009-11-10 Ardian, Inc. Methods and apparatus for thermally-induced renal neuromodulation
US9636174B2 (en) * 2002-04-08 2017-05-02 Medtronic Ardian Luxembourg S.A.R.L. Methods for therapeutic renal neuromodulation
US20070129761A1 (en) 2002-04-08 2007-06-07 Ardian, Inc. Methods for treating heart arrhythmia
US7653438B2 (en) 2002-04-08 2010-01-26 Ardian, Inc. Methods and apparatus for renal neuromodulation
US7756583B2 (en) 2002-04-08 2010-07-13 Ardian, Inc. Methods and apparatus for intravascularly-induced neuromodulation
ATE504330T1 (de) 2002-04-11 2011-04-15 Medtronic Vascular Inc Vorrichtungen für die transluminale oder transthorakale interstitielle elektrodenplatzierung
EP1494752B1 (en) 2002-04-16 2008-07-30 Cyto Pulse Sciences, Inc. Method of treating biological materials with translating electrical fields and electrode polarity reversal
US20030199767A1 (en) 2002-04-19 2003-10-23 Cespedes Eduardo Ignacio Methods and apparatus for the identification and stabilization of vulnerable plaque
US20030236443A1 (en) 2002-04-19 2003-12-25 Cespedes Eduardo Ignacio Methods and apparatus for the identification and stabilization of vulnerable plaque
US20030199747A1 (en) 2002-04-19 2003-10-23 Michlitsch Kenneth J. Methods and apparatus for the identification and stabilization of vulnerable plaque
US20030199768A1 (en) 2002-04-19 2003-10-23 Cespedes Eduardo Ignacio Methods and apparatus for the identification and stabilization of vulnerable plaque
US20040147828A1 (en) 2002-04-22 2004-07-29 Gibson Charles A. Telescoping tip electrode catheter
DE10218426A1 (de) 2002-04-24 2003-11-06 Biotronik Mess & Therapieg Ablationsvorrichtung für Herzgewebe, insbesondere zur Erzeugung linearer Läsionen zwischen zwei Gefäßmündungen im Herzen
DE10218427A1 (de) 2002-04-24 2003-11-06 Biotronik Mess & Therapieg Ablationsvorrichtung für Herzgewebe, insbesondere zur Erzeugung einer zirkulären Läsion um eine Gefäßmündung im Herzen
US20030204161A1 (en) 2002-04-25 2003-10-30 Bozidar Ferek-Petric Implantable electroporation therapy device and method for using same
US6746474B2 (en) 2002-05-31 2004-06-08 Vahid Saadat Apparatus and methods for cooling a region within the body
US6748953B2 (en) 2002-06-11 2004-06-15 Scimed Life Systems, Inc. Method for thermal treatment of type II endoleaks in arterial aneurysms
JP2004016333A (ja) 2002-06-13 2004-01-22 Unique Medical Co Ltd 硬膜外麻酔用カテーテルおよび該硬膜外麻酔用カテーテルを用いる電気刺激装置
JP3813112B2 (ja) 2002-06-26 2006-08-23 テルモ株式会社 カテーテルおよび医療用チューブ
US6717384B2 (en) 2002-07-10 2004-04-06 Kentfa Electric Motorbike Corporation Frequency changer protection circuit for controlling the acceleration of an electric vehicle
US7115134B2 (en) 2002-07-22 2006-10-03 Chambers Technology, Llc. Catheter with flexible tip and shape retention
US7878984B2 (en) 2002-07-25 2011-02-01 Boston Scientific Scimed, Inc. Medical device for navigation through anatomy and method of making same
US7914467B2 (en) 2002-07-25 2011-03-29 Boston Scientific Scimed, Inc. Tubular member having tapered transition for use in a medical device
US20040024392A1 (en) * 2002-08-05 2004-02-05 Lewis James D. Apparatus and method for cryosurgery
US7058456B2 (en) 2002-08-09 2006-06-06 Concentric Medical, Inc. Methods and devices for changing the shape of a medical device
US6893414B2 (en) 2002-08-12 2005-05-17 Breg, Inc. Integrated infusion and aspiration system and method
US20040193228A1 (en) 2003-03-31 2004-09-30 Gerber Martin T. Method, system and device for treating various disorders of the pelvic floor by electrical stimulation of the left and right pudendal nerves
US6780183B2 (en) 2002-09-16 2004-08-24 Biosense Webster, Inc. Ablation catheter having shape-changing balloon
WO2004107965A2 (en) 2002-09-20 2004-12-16 Flowmedica, Inc. Systems and methods for performing bi-lateral interventions or diagnosis in branched body lumens
US7150741B2 (en) 2002-09-20 2006-12-19 Advanced Neuromodulation Systems, Inc. Programmable dose control module
WO2004026371A2 (en) 2002-09-20 2004-04-01 Flowmedica, Inc. Method and apparatus for selective drug infusion via an intraaortic flow diverter delivery catheter
EP1624909A2 (en) 2002-09-20 2006-02-15 FlowMedica, Inc. Appartus and method for inserting an intra-aorta catheter trough a delivery sheath
US7993325B2 (en) 2002-09-20 2011-08-09 Angio Dynamics, Inc. Renal infusion systems and methods
EP1539291A4 (en) 2002-09-20 2010-03-10 Flowmedica Inc METHOD AND DEVICE FOR SELECTIVE INFUSION BY CATHETER INTRA-RENAL
EP1585572A4 (en) 2002-09-20 2010-02-24 Flowmedica Inc METHOD AND APPARATUS FOR ADMINISTERING INTRA-AORTIC SUBSTANCE TO A BRANCHED VESSEL
US7063679B2 (en) 2002-09-20 2006-06-20 Flowmedica, Inc. Intra-aortic renal delivery catheter
KR20050084599A (ko) 2002-09-26 2005-08-26 안지오테크 인터내셔날 아게 혈관주위 랩
US7282213B2 (en) 2002-09-30 2007-10-16 Medtronic, Inc. Method for applying a drug coating to a medical device
WO2004033034A1 (en) 2002-10-04 2004-04-22 Microchips, Inc. Medical device for neural stimulation and controlled drug delivery
DE60331455D1 (de) 2002-10-04 2010-04-08 Microchips Inc Medizinische vorrichtung zur gesteuerten arzneimittelverabreichung sowie herzüberwachung und/oder herzstimulation
US20050033137A1 (en) 2002-10-25 2005-02-10 The Regents Of The University Of Michigan Ablation catheters and methods for their use
WO2004039273A2 (en) 2002-10-31 2004-05-13 C.R. Bard, Inc. Electrophysiology catheter with biased tip
US20030229380A1 (en) * 2002-10-31 2003-12-11 Adams John M. Heart failure therapy device and method
DE10252325B4 (de) 2002-11-11 2012-10-25 Admedes Schuessler Gmbh Sonde zur Hochfrequenz-Thermoablation sowie Verfahren zu deren Herstellung
DE10257146A1 (de) * 2002-12-06 2004-06-24 Admedes Schuessler Gmbh Metallelektrode
AU2002952663A0 (en) * 2002-11-14 2002-11-28 Western Sydney Area Health Service An intramural needle-tipped surgical device
US7404824B1 (en) 2002-11-15 2008-07-29 Advanced Cardiovascular Systems, Inc. Valve aptation assist device
US20040106954A1 (en) * 2002-11-15 2004-06-03 Whitehurst Todd K. Treatment of congestive heart failure
US20050004515A1 (en) 2002-11-15 2005-01-06 Hart Charles C. Steerable kink resistant sheath
US7317950B2 (en) * 2002-11-16 2008-01-08 The Regents Of The University Of California Cardiac stimulation system with delivery of conductive agent
ITBS20020107A1 (it) 2002-11-25 2004-05-26 Invatec Srl Tubo metallico con almeno una parte di lunghezza a flessibilita' variabile.
US8509916B2 (en) * 2002-12-16 2013-08-13 Medtronic, Inc. Bilumen guide catheters for accessing cardiac sites
US20040162590A1 (en) 2002-12-19 2004-08-19 Whitehurst Todd K. Fully implantable miniature neurostimulator for intercostal nerve stimulation as a therapy for angina pectoris
US7890188B2 (en) 2002-12-19 2011-02-15 Cardiac Pacemakers, Inc. Implantable lead for septal placement of electrode with fixation mechanism in the pulmonary artery
US6978180B2 (en) 2003-01-03 2005-12-20 Advanced Neuromodulation Systems, Inc. System and method for stimulation of a person's brain stem
US6847848B2 (en) 2003-01-07 2005-01-25 Mmtc, Inc Inflatable balloon catheter structural designs and methods for treating diseased tissue of a patient
US6960207B2 (en) 2003-01-21 2005-11-01 St Jude Medical, Daig Division, Inc. Ablation catheter having a virtual electrode comprising portholes and a porous conductor
US7013169B2 (en) 2003-01-27 2006-03-14 Cardiac Pacemakers, Inc. Dual steer preshaped catheter
WO2006020920A2 (en) 2003-01-29 2006-02-23 Medtronic, Inc. Catheter apparatus for treatment of heart arrhythmia
US8066700B2 (en) 2003-01-31 2011-11-29 Smith & Nephew, Inc. Cartilage treatment probe
US7444183B2 (en) 2003-02-03 2008-10-28 Enteromedics, Inc. Intraluminal electrode apparatus and method
US6941953B2 (en) 2003-02-20 2005-09-13 Medwaves, Inc. Preformed catheter set for use with a linear ablation system to produce ablation lines in the left and right atrium for treatment of atrial fibrillation
US7837676B2 (en) 2003-02-20 2010-11-23 Recor Medical, Inc. Cardiac ablation devices
US6923808B2 (en) 2003-02-24 2005-08-02 Boston Scientific Scimed, Inc. Probes having helical and loop shaped inflatable therapeutic elements
EP1599240A4 (en) 2003-02-24 2007-06-06 Plc Medical Systems Inc CATHETER METHOD AND SYSTEM APPLICABLE IN CASE OF ACUTE RENAL FAILURE
US7004911B1 (en) 2003-02-24 2006-02-28 Hosheng Tu Optical thermal mapping for detecting vulnerable plaque
EP1605875A3 (en) 2003-03-03 2005-12-28 Sinus Rhythm Technologies, Inc. Electrical block positioning devices and methods of use therefor
US20040176699A1 (en) 2003-03-03 2004-09-09 Volcano Therapeutics, Inc. Thermography catheter with improved wall contact
US7250041B2 (en) 2003-03-12 2007-07-31 Abbott Cardiovascular Systems Inc. Retrograde pressure regulated infusion
US7186251B2 (en) 2003-03-27 2007-03-06 Cierra, Inc. Energy based devices and methods for treatment of patent foramen ovale
US7922714B2 (en) 2003-03-28 2011-04-12 C.R. Bard, Inc. Method and apparatus for selecting operating parameter values in electrophysiology procedures
US7938828B2 (en) 2003-03-28 2011-05-10 Boston Scientific Scimed, Inc. Cooled ablation catheter
US7597704B2 (en) 2003-04-28 2009-10-06 Atritech, Inc. Left atrial appendage occlusion device with active expansion
US7517342B2 (en) 2003-04-29 2009-04-14 Boston Scientific Scimed, Inc. Polymer coated device for electrically medicated drug delivery
US7221979B2 (en) 2003-04-30 2007-05-22 Medtronic, Inc. Methods and apparatus for the regulation of hormone release
US7544197B2 (en) 2003-05-06 2009-06-09 Greatbatch Ltd. Rotatable lead introducer
DE10323566B4 (de) 2003-05-26 2006-03-23 Fehling Ag Instrument zur unipolaren Ablation von Herzgewebe
EP1635736A2 (en) 2003-06-05 2006-03-22 FlowMedica, Inc. Systems and methods for performing bi-lateral interventions or diagnosis in branched body lumens
US7738952B2 (en) 2003-06-09 2010-06-15 Palo Alto Investors Treatment of conditions through modulation of the autonomic nervous system
US7149574B2 (en) 2003-06-09 2006-12-12 Palo Alto Investors Treatment of conditions through electrical modulation of the autonomic nervous system
US20060167437A1 (en) 2003-06-17 2006-07-27 Flowmedica, Inc. Method and apparatus for intra aortic substance delivery to a branch vessel
US7789877B2 (en) 2003-07-02 2010-09-07 St. Jude Medical, Atrial Fibrillation Division, Inc. Ablation catheter electrode arrangement
JP4810425B2 (ja) 2003-07-18 2011-11-09 イースタン バージニア メディカル スクール 電気パルスを発生するための装置および該装置を使用する方法
US7670335B2 (en) 2003-07-21 2010-03-02 Biosense Webster, Inc. Ablation device with spiral array ultrasound transducer
EP1659970A4 (en) 2003-08-05 2008-05-21 Flowmedica Inc SYSTEM AND METHOD FOR PREVENTING RADIO CONTRAST-INDUCED NEPHROPATHY
US7742809B2 (en) 2003-08-25 2010-06-22 Medtronic, Inc. Electroporation catheter with sensing capabilities
US7766868B2 (en) 2003-09-05 2010-08-03 Medtronic, Inc. Deflectable medical therapy delivery device having common lumen profile
US7156843B2 (en) 2003-09-08 2007-01-02 Medtronic, Inc. Irrigated focal ablation tip
DE202004021944U1 (de) 2003-09-12 2013-07-16 Vessix Vascular, Inc. Auswählbare exzentrische Remodellierung und/oder Ablation von atherosklerotischem Material
US7502650B2 (en) 2003-09-22 2009-03-10 Cvrx, Inc. Baroreceptor activation for epilepsy control
US7435248B2 (en) 2003-09-26 2008-10-14 Boston Scientific Scimed, Inc. Medical probes for creating and diagnosing circumferential lesions within or around the ostium of a vessel
US7998112B2 (en) 2003-09-30 2011-08-16 Abbott Cardiovascular Systems Inc. Deflectable catheter assembly and method of making same
US7591813B2 (en) 2003-10-01 2009-09-22 Micrus Endovascular Corporation Long nose manipulatable catheter
US20050153885A1 (en) 2003-10-08 2005-07-14 Yun Anthony J. Treatment of conditions through modulation of the autonomic nervous system
US7186209B2 (en) 2003-10-09 2007-03-06 Jacobson Jerry I Cardioelectromagnetic treatment
US7416549B2 (en) 2003-10-10 2008-08-26 Boston Scientific Scimed, Inc. Multi-zone bipolar ablation probe assembly
WO2005037070A2 (en) 2003-10-11 2005-04-28 The Regents Of The University Of California Method and system for nerve repair, nanoknife, mems platform and uses thereof
US7220374B2 (en) * 2003-10-22 2007-05-22 Cadillac Products Automotive Company Molded foam vehicle energy absorbing device and method of manufacture
US7480532B2 (en) 2003-10-22 2009-01-20 Cvrx, Inc. Baroreflex activation for pain control, sedation and sleep
US7254451B2 (en) 2003-11-20 2007-08-07 Medtronic, Inc. Implantable lead including sensor
EP1686909B1 (en) 2003-11-25 2018-08-01 Cathrx Ltd A modular catheter
US7783353B2 (en) 2003-12-24 2010-08-24 Cardiac Pacemakers, Inc. Automatic neural stimulation modulation based on activity and circadian rhythm
US8396560B2 (en) 2004-11-18 2013-03-12 Cardiac Pacemakers, Inc. System and method for closed-loop neural stimulation
US20080015659A1 (en) 2003-12-24 2008-01-17 Yi Zhang Neurostimulation systems and methods for cardiac conditions
US8048067B2 (en) 2003-12-24 2011-11-01 The Regents Of The University Of California Tissue ablation with irreversible electroporation
CN1913935B (zh) 2004-01-26 2010-05-12 导管治疗有限公司 带有可调环的导管组件
US7637903B2 (en) 2004-02-09 2009-12-29 Cryocor, Inc. Catheter articulation segment with alternating cuts
US7245955B2 (en) 2004-02-23 2007-07-17 St. Jude Medical, Atrial Fibrillation Division, Inc. Electrophysiology/ablation catheter having deflection assembly
WO2005084389A2 (en) 2004-03-02 2005-09-15 Cvrx, Inc. External baroreflex activation
WO2005091910A2 (en) 2004-03-04 2005-10-06 Flowmedica, Inc. Sheath for use in peripheral interventions
US7976539B2 (en) 2004-03-05 2011-07-12 Hansen Medical, Inc. System and method for denaturing and fixing collagenous tissue
US20050209548A1 (en) 2004-03-19 2005-09-22 Dev Sukhendu B Electroporation-mediated intravascular delivery
EP1750799A2 (en) 2004-05-04 2007-02-14 The Cleveland Clinic Foundation Methods of treating medical conditions by neuromodulation of the sympathetic nervous system
US8412348B2 (en) 2004-05-06 2013-04-02 Boston Scientific Neuromodulation Corporation Intravascular self-anchoring integrated tubular electrode body
US7758564B2 (en) 2004-05-14 2010-07-20 Ethicon Endo-Surgery, Inc. Medical instrument having a catheter and a medical guidewire
JP2007537298A (ja) 2004-05-14 2007-12-20 フロウメディカ， インコーポレイテッド うっ血性心不全の処置およびｂｎｐ療法のための両側性局所腎臓送達
JP2008516638A (ja) 2004-05-14 2008-05-22 カーディマ・インコーポレイテッド 補強部材を備えた除去プローブ
US20050261672A1 (en) 2004-05-18 2005-11-24 Mark Deem Systems and methods for selective denervation of heart dysrhythmias
US7632265B2 (en) 2004-05-28 2009-12-15 St. Jude Medical, Atrial Fibrillation Division, Inc. Radio frequency ablation servo catheter and method
US7294119B2 (en) 2004-06-10 2007-11-13 Safety Syringes, Inc. Passive delivery system diluents mixing and delivery
WO2005123183A2 (en) 2004-06-11 2005-12-29 University Of South Florida Electroporation device and method for delivery to ocular tissue
US20060004346A1 (en) 2004-06-17 2006-01-05 Begg John D Bend relief
US20060067972A1 (en) 2004-06-23 2006-03-30 Flowmedica, Inc. Devices for renal-based heart failure treatment
CA2572290A1 (en) 2004-06-24 2006-02-02 Ksn Energies, Llc Electrical impedance tomography to characterize tissue
WO2006012050A2 (en) 2004-06-30 2006-02-02 Cvrx, Inc. Connection structures for extra-vascular electrode lead body
US20060004417A1 (en) 2004-06-30 2006-01-05 Cvrx, Inc. Baroreflex activation for arrhythmia treatment
US7850675B2 (en) 2004-07-20 2010-12-14 Boston Scientific Scimed, Inc. Reinforced venous access catheter
FR2873385B1 (fr) 2004-07-23 2006-10-27 Centre Nat Rech Scient Cnrse Surveillance et controle d'une electroporation
CN101035593B (zh) 2004-07-28 2011-05-25 阿迪安公司 肾神经阻滞的方法及装置
US7373204B2 (en) 2004-08-19 2008-05-13 Lifestim, Inc. Implantable device and method for treatment of hypertension
EP1796568A1 (en) 2004-09-09 2007-06-20 Vnus Medical Technologies, Inc. Methods and apparatus for treatment of hollow anatomical structures
WO2006031899A2 (en) 2004-09-10 2006-03-23 The Cleveland Clinic Foundation Intraluminal electrode assembly
US9713730B2 (en) 2004-09-10 2017-07-25 Boston Scientific Scimed, Inc. Apparatus and method for treatment of in-stent restenosis
US8396548B2 (en) 2008-11-14 2013-03-12 Vessix Vascular, Inc. Selective drug delivery in a lumen
US7753906B2 (en) 2004-09-14 2010-07-13 Richard Esposito Catheter having anchoring and stabilizing devices
US7542808B1 (en) 2004-09-17 2009-06-02 Cardiac Pacemakers, Inc. Lead and catheter assembly
US20060069323A1 (en) 2004-09-24 2006-03-30 Flowmedica, Inc. Systems and methods for bi-lateral guidewire cannulation of branched body lumens
US20060074403A1 (en) 2004-09-29 2006-04-06 Nasser Rafiee Curved catheter comprising a solid-walled metal tube with varying stiffness
US20060074453A1 (en) 2004-10-04 2006-04-06 Cvrx, Inc. Baroreflex activation and cardiac resychronization for heart failure treatment
US9101386B2 (en) 2004-10-15 2015-08-11 Amendia, Inc. Devices and methods for treating tissue
CA2584138A1 (en) 2004-10-18 2006-04-27 Raphael C. Lee Methods and compositions for treatment of free radical injury
US7524318B2 (en) 2004-10-28 2009-04-28 Boston Scientific Scimed, Inc. Ablation probe with flared electrodes
US7937143B2 (en) * 2004-11-02 2011-05-03 Ardian, Inc. Methods and apparatus for inducing controlled renal neuromodulation
US20070083239A1 (en) * 2005-09-23 2007-04-12 Denise Demarais Methods and apparatus for inducing, monitoring and controlling renal neuromodulation
US8409191B2 (en) 2004-11-04 2013-04-02 Boston Scientific Scimed, Inc. Preshaped ablation catheter for ablating pulmonary vein ostia within the heart
WO2006052940A2 (en) 2004-11-05 2006-05-18 Asthmatx, Inc. Medical device with procedure improvement features
US20060100618A1 (en) 2004-11-08 2006-05-11 Cardima, Inc. System and method for performing ablation and other medical procedures using an electrode array with flex circuit
WO2006055654A1 (en) 2004-11-15 2006-05-26 Biosense Webster Inc. Catheter with microfabricated temperature sensing
US8332047B2 (en) 2004-11-18 2012-12-11 Cardiac Pacemakers, Inc. System and method for closed-loop neural stimulation
US20060116720A1 (en) 2004-12-01 2006-06-01 Penny Knoblich Method and apparatus for improving renal function
US7937160B2 (en) 2004-12-10 2011-05-03 Boston Scientific Neuromodulation Corporation Methods for delivering cortical electrode leads into patient's head
US7402151B2 (en) 2004-12-17 2008-07-22 Biocardia, Inc. Steerable guide catheters and methods for their use
US8983582B2 (en) 2004-12-20 2015-03-17 Advanced Cardiovascular Systems, Inc. Methods and apparatuses for positioning within an internal channel
EP1835964B1 (en) 2004-12-21 2016-03-09 EBR Systems, Inc. Leadless cardiac system for pacing and arrhythmia treatment
US20060135953A1 (en) 2004-12-22 2006-06-22 Wlodzimierz Kania Tissue ablation system including guidewire with sensing element
EP1833554A2 (en) 2004-12-27 2007-09-19 Standen Ltd. Treating a tumor or the like with electric fields at different orientations
US9833618B2 (en) 2005-02-04 2017-12-05 Palo Alto Investors Methods and compositions for treating a disease condition in a subject
US20060182873A1 (en) 2005-02-17 2006-08-17 Klisch Leo M Medical devices
US7828837B2 (en) 2005-02-17 2010-11-09 Khoury Medical Devices, LLC. Vascular endograft
US7548780B2 (en) 2005-02-22 2009-06-16 Cardiac Pacemakers, Inc. Cell therapy and neural stimulation for cardiac repair
CN101132743A (zh) 2005-03-02 2008-02-27 导管治疗有限公司 热疗导管
EP1865870B8 (en) 2005-03-28 2012-04-04 Vessix Vascular, Inc. Intraluminal electrical tissue characterization and tuned rf energy for selective treatment of atheroma and other target tissues
US7727187B2 (en) 2005-04-04 2010-06-01 Cook Incorporated Scored catheter device
US7499748B2 (en) 2005-04-11 2009-03-03 Cardiac Pacemakers, Inc. Transvascular neural stimulation device
US20110046607A1 (en) 2005-05-02 2011-02-24 Resqmedical Ltd. Self-withdrawing catheter for injecting into body passageways and kit containing same
CA2607935C (en) 2005-05-05 2014-07-08 Boston Scientific Limited Preshaped localization catheter and system for graphically reconstructing pulmonary vein ostia
US7806871B2 (en) 2005-05-09 2010-10-05 Boston Scientific Scimed, Inc. Method and device for tissue removal and for delivery of a therapeutic agent or bulking agent
DE102005023303A1 (de) 2005-05-13 2006-11-16 Celon Ag Medical Instruments Biegeweiche Applikationsvorrichtung zur Hochfrequenztherapie von biologischem Gewebe
US7857810B2 (en) 2006-05-16 2010-12-28 St. Jude Medical, Atrial Fibrillation Division, Inc. Ablation electrode assembly and methods for improved control of temperature and minimization of coagulation and tissue damage
EP1895927A4 (en) 2005-06-20 2011-03-09 Medtronic Ablation Frontiers ABLATION CATHETER
WO2007002304A2 (en) 2005-06-22 2007-01-04 Vnus Medical Technologies, Inc. Methods and apparatus for introducing tumescent fluid to body tissue
US7717853B2 (en) 2005-06-24 2010-05-18 Henry Nita Methods and apparatus for intracranial ultrasound delivery
ES2670822T3 (es) 2005-06-29 2018-06-01 Zoll Circulation, Inc. Dispositivos y sistemas para el enfriamiento endovascular rápido
WO2007008954A2 (en) 2005-07-11 2007-01-18 Ablation Frontiers Low power tissue ablation system
US20070021803A1 (en) * 2005-07-22 2007-01-25 The Foundry Inc. Systems and methods for neuromodulation for treatment of pain and other disorders associated with nerve conduction
US8140170B2 (en) 2005-09-12 2012-03-20 The Cleveland Clinic Foundation Method and apparatus for renal neuromodulation
DE102005047073A1 (de) 2005-09-30 2007-04-05 BSH Bosch und Siemens Hausgeräte GmbH Staubsauger mit Fliehkraftabscheider
US8712522B1 (en) 2005-10-18 2014-04-29 Cvrx, Inc. System for setting programmable parameters for an implantable hypertension treatment device
WO2007055521A1 (en) 2005-11-09 2007-05-18 Korea University Industrial & Academic Collaboration Foundation Radio frequency ablation electrode for selected tissue removal
US7647124B2 (en) 2005-11-15 2010-01-12 Medtronic, Inc. Delivery catheter
US7729782B2 (en) 2005-11-15 2010-06-01 Medtronic, Inc. Delivery catheter
US20080045890A1 (en) 2005-12-16 2008-02-21 Mercator Medsystems, Inc. Methods and systems for ablating tissue
US7993334B2 (en) 2005-12-29 2011-08-09 Boston Scientific Scimed, Inc. Low-profile, expanding single needle ablation probe
US20070156200A1 (en) 2005-12-29 2007-07-05 Lilian Kornet System and method for regulating blood pressure and electrolyte balance
US20070162109A1 (en) 2006-01-11 2007-07-12 Luis Davila Intraluminal stent graft
CA2638028A1 (en) 2006-01-27 2007-08-09 Medtronic, Inc. Ablation device with lockout feature
US7662151B2 (en) 2006-02-15 2010-02-16 Boston Scientific Scimed, Inc. Contact sensitive probes
US20070208256A1 (en) 2006-03-03 2007-09-06 Medtronic Vascular, Inc. Multiple Branch Tubular Prosthesis and Methods
US8571650B2 (en) 2006-03-03 2013-10-29 Palo Alto Investors Methods and compositions for treating a renal associated condition in a subject
US20070225781A1 (en) 2006-03-21 2007-09-27 Nidus Medical, Llc Apparatus and methods for altering temperature in a region within the body
US7747334B2 (en) 2006-03-23 2010-06-29 Cardiac Pacemakers, Inc. Left ventricular lead shapes
US7579550B2 (en) 2006-03-31 2009-08-25 Boston Scientific Scimed, Inc. Flexible device shaft with angled spiral wrap
US20080004673A1 (en) 2006-04-03 2008-01-03 Cvrx, Inc. Implantable extravascular electrostimulation system having a resilient cuff
US20070255270A1 (en) 2006-04-27 2007-11-01 Medtronic Vascular, Inc. Intraluminal guidance system using bioelectric impedance
US8019435B2 (en) 2006-05-02 2011-09-13 Boston Scientific Scimed, Inc. Control of arterial smooth muscle tone
CN101437567A (zh) 2006-05-08 2009-05-20 导管治疗有限公司 形状赋予机构插入物
US20080004596A1 (en) 2006-05-25 2008-01-03 Palo Alto Institute Delivery of agents by microneedle catheter
US7615067B2 (en) 2006-06-05 2009-11-10 Cambridge Endoscopic Devices, Inc. Surgical instrument
US20070282376A1 (en) 2006-06-06 2007-12-06 Shuros Allan C Method and apparatus for neural stimulation via the lymphatic system
US7647101B2 (en) 2006-06-09 2010-01-12 Cardiac Pacemakers, Inc. Physical conditioning system, device and method
CN101610735B (zh) * 2006-06-28 2015-07-01 美敦力Af卢森堡公司 用于热诱导的肾神经调制的方法和系统
EP2049184B1 (en) 2006-07-26 2013-02-13 Johan Willem Pieter Marsman Facilitation of antegrade insertion of a guidewire into the superficial femoral artery
US7708704B2 (en) 2006-07-31 2010-05-04 Codman & Shurtleff, Pc Interventional medical device component having an interrupted spiral section and method of making the same
US20080039904A1 (en) 2006-08-08 2008-02-14 Cherik Bulkes Intravascular implant system
US7674253B2 (en) 2006-08-18 2010-03-09 Kensey Nash Corporation Catheter for conducting a procedure within a lumen, duct or organ of a living being
US20080051704A1 (en) 2006-08-28 2008-02-28 Patel Rajnikant V Catheter and system for using same
US20080064957A1 (en) 2006-09-07 2008-03-13 Spence Paul A Ultrasonic implant, systems and methods related to diverting material in blood flow away from the head
US20080091255A1 (en) 2006-10-11 2008-04-17 Cardiac Pacemakers Implantable neurostimulator for modulating cardiovascular function
EP2455036B1 (en) 2006-10-18 2015-07-15 Vessix Vascular, Inc. Tuned RF energy and electrical tissue characterization for selective treatment of target tissues
US8317773B2 (en) 2006-11-07 2012-11-27 Angio Dynamics, Inc. Catheter with open faced sloped end portion
US8915926B2 (en) 2006-11-08 2014-12-23 Advanced Bionics Ag Pre-curved electrode array loading tools
JP2010510834A (ja) 2006-11-28 2010-04-08 カソリック リミテッド カテーテル操縦／挿入機構
US7955326B2 (en) 2006-12-29 2011-06-07 St. Jude Medical, Atrial Fibrillation Division, Inc. Pressure-sensitive conductive composite electrode and method for ablation
US20080183187A1 (en) 2007-01-30 2008-07-31 Cardiac Pacemakers, Inc. Direct delivery system for transvascular lead
WO2008101244A2 (en) 2007-02-18 2008-08-21 Via Biomedical, Inc. Guiding catheter support devices and methods
US10166066B2 (en) 2007-03-13 2019-01-01 University Of Virginia Patent Foundation Epicardial ablation catheter and method of use
US8187267B2 (en) 2007-05-23 2012-05-29 St. Jude Medical, Atrial Fibrillation Division, Inc. Ablation catheter with flexible tip and methods of making the same
DE102007018277A1 (de) 2007-04-18 2008-10-30 Medical Service Gmbh Katheter-Set
US8103359B2 (en) 2007-05-17 2012-01-24 Cardiac Pacemakers, Inc. Systems and methods for fixating transvenously implanted medical devices
US8630704B2 (en) 2007-06-25 2014-01-14 Cardiac Pacemakers, Inc. Neural stimulation with respiratory rhythm management
US8864675B2 (en) 2007-06-28 2014-10-21 W. L. Gore & Associates, Inc. Catheter
US7863897B2 (en) 2007-09-07 2011-01-04 The General Hospital Corporation Method and apparatus for characterizing the temporal resolution of an imaging device
EP2211701A1 (en) 2007-10-26 2010-08-04 St. Jude Medical Systems AB Sensor guide wire with micro-cable winding
US8118809B2 (en) 2007-12-21 2012-02-21 St. Jude Medical, Atrial Fibrillation Division, Inc. Flexible conductive polymer electrode and method for ablation
US20100286626A1 (en) 2007-12-21 2010-11-11 Petersen Scott R Longitudinally incompressible, laterally flexible interior shaft for catheter
US7949398B1 (en) 2007-12-27 2011-05-24 Pacesetter, Inc. Acquiring nerve activity from carotid body and/or sinus
US7848816B1 (en) 2007-12-27 2010-12-07 Pacesetter, Inc. Acquiring nerve activity from carotid body and/or sinus
US9204927B2 (en) 2009-05-13 2015-12-08 St. Jude Medical, Atrial Fibrillation Division, Inc. System and method for presenting information representative of lesion formation in tissue during an ablation procedure
US7985215B2 (en) 2007-12-28 2011-07-26 St. Jude Medical, Atrial Fibrillation Division, Inc. Deflectable catheter with distal deflectable segment
US20120239004A1 (en) 2008-03-03 2012-09-20 Mk International Pty Ltd Catheter with friction reducing surface shaping
WO2009121017A1 (en) 2008-03-27 2009-10-01 The Regents Of The University Of California Balloon catheter for reducing restenosis via irreversible electroporation
EP2106821B1 (en) 2008-03-31 2019-04-17 Dentsply IH AB Catheter assembly comprising a tubular member having pleated regions, and methods of activating and manufacturing the same
JP4362536B2 (ja) 2008-04-11 2009-11-11 日本ライフライン株式会社 カテーテル
DE102008019827A1 (de) 2008-04-19 2009-10-29 Biotronik Crm Patent Ag Steuerbare Elektrode zur tiefen Hirnstimulation
JP2011519699A (ja) 2008-05-09 2011-07-14 インノブアトイブエ プルモナルイ ソルウトイオンス，インコーポレイティッド 気管支樹の治療のためのシステム、アセンブリ、及び方法
US8480663B2 (en) 2008-05-15 2013-07-09 Boston Scientific Scimed, Inc. Apparatus and methods for cryogenically ablating tissue and adjusting cryogenic ablation regions
US8437832B2 (en) 2008-06-06 2013-05-07 Biosense Webster, Inc. Catheter with bendable tip
US20090306651A1 (en) 2008-06-09 2009-12-10 Clint Schneider Catheter assembly with front-loaded tip
JP2010021134A (ja) 2008-06-11 2010-01-28 Sumitomo Chemical Co Ltd リチウム複合金属酸化物の製造方法
WO2010005714A1 (en) 2008-06-16 2010-01-14 Twin Star Medical, Inc. Flexible catheter
US8100859B2 (en) 2008-06-24 2012-01-24 Cook Medical Technologies Llc Bent obturator
US20100004632A1 (en) 2008-07-03 2010-01-07 Kirk Kochin Wu Magnetic guided ablation catheter
US20100022989A1 (en) 2008-07-25 2010-01-28 Parasmo Ronald S Steerable catheter and method of making the same
US8123739B2 (en) 2008-08-19 2012-02-28 Cook Medical Technologies Llc Drainage catheter and method for catheterizing a patient
US8172831B2 (en) 2008-09-02 2012-05-08 Abbott Cardiovascular Systems Inc. Catheter configured for incremental rotation
US20100069882A1 (en) 2008-09-18 2010-03-18 Boston Scientific Scimed, Inc. Medical device with preferential bending
US20100099952A1 (en) 2008-10-22 2010-04-22 Boston Scientific Scimed, Inc. Steerable Shaft Having Micromachined Tube
US9084869B2 (en) 2008-10-31 2015-07-21 Cathrx, Ltd Catheter assembly
US20150105659A1 (en) 2008-11-11 2015-04-16 Covidien Lp Energy delivery device and methods of use
US11376061B2 (en) 2008-11-11 2022-07-05 Covidien Lp Energy delivery device and methods of use
WO2010056771A1 (en) 2008-11-11 2010-05-20 Shifamed Llc Low profile electrode assembly
US8317810B2 (en) 2008-12-29 2012-11-27 St. Jude Medical, Atrial Fibrillation Division, Inc. Tissue puncture assemblies and methods for puncturing tissue
US8123721B2 (en) 2008-12-31 2012-02-28 St. Jude Medical, Atrial Fibrillation Division, Inc. Catheter having independently-deflectable segments and method of its manufacture
US8652129B2 (en) 2008-12-31 2014-02-18 Medtronic Ardian Luxembourg S.A.R.L. Apparatus, systems, and methods for achieving intravascular, thermally-induced renal neuromodulation
US20100168739A1 (en) 2008-12-31 2010-07-01 Ardian, Inc. Apparatus, systems, and methods for achieving intravascular, thermally-induced renal neuromodulation
US8808345B2 (en) * 2008-12-31 2014-08-19 Medtronic Ardian Luxembourg S.A.R.L. Handle assemblies for intravascular treatment devices and associated systems and methods
EP2387433A4 (en) 2009-01-15 2012-07-18 Cathrx Ltd ORIENTABLE PEN
US10166067B2 (en) 2009-02-12 2019-01-01 St. Jude Medical, Atrial Fibrillation Division, Inc. Ablation catheter and method for electically isolating cardiac tissue
EP2398543A1 (en) 2009-02-20 2011-12-28 Boston Scientific Scimed, Inc. Asymmetric dual directional steerable catheter sheath
US8725228B2 (en) 2009-02-20 2014-05-13 Boston Scientific Scimed, Inc. Steerable catheter having intermediate stiffness transition zone
CN201356648Y (zh) 2009-03-04 2009-12-09 微创医疗器械(上海)有限公司 盐水灌注射频消融导管
US8929969B2 (en) 2009-04-14 2015-01-06 Medtronic Ablation Frontiers Llc Catheter assembly and associated method
CN104825445A (zh) 2009-04-22 2015-08-12 墨卡托医疗系统公司 局部血管递送胍乙啶在治疗高血压中的用途
US8551096B2 (en) 2009-05-13 2013-10-08 Boston Scientific Scimed, Inc. Directional delivery of energy and bioactives
US20120035615A1 (en) 2009-05-22 2012-02-09 Advanced Bionics, Llc Composite Stylet
US8282633B2 (en) 2009-06-15 2012-10-09 Olympus Medical Systems Corp. High-frequency surgical apparatus and high-frequency surgical method for closure of patent foramen ovale
EP2445568B1 (en) 2009-06-24 2020-09-23 Kalila Medical, Inc. Steerable medical delivery devices
WO2011015218A1 (en) 2009-08-06 2011-02-10 Ls Medcap Gmbh Catheter with two fenestrations
US8435228B2 (en) 2009-08-12 2013-05-07 Medrad, Inc. Interventional catheter assemblies incorporating guide wire brake and management systems
EP2464301B1 (en) 2009-08-14 2016-07-06 Boston Scientific Scimed, Inc. Systems for making and using medical ablation systems having mapping catheters with improved anchoring ability
CN201469401U (zh) 2009-08-21 2010-05-19 刘小青 螺旋状环肾动脉肾交感神经射频消融电极导管
US9439721B2 (en) 2009-08-25 2016-09-13 Medtronic Ablation Frontiers Llc Bi-modal linear and loop ablation catheter, and method
US8568401B2 (en) 2009-10-27 2013-10-29 Covidien Lp System for monitoring ablation size
WO2011055143A2 (en) 2009-11-04 2011-05-12 Emcision Limited Lumenal remodelling device and methods
US20110112400A1 (en) 2009-11-06 2011-05-12 Ardian, Inc. High intensity focused ultrasound catheter apparatuses, systems, and methods for renal neuromodulation
CN102711645B (zh) 2009-11-11 2016-12-28 赫莱拉公司 用于处理组织和控制狭窄的系统和装置
EP2332607A1 (en) 2009-12-14 2011-06-15 The Royal College of Surgeons in Ireland A urethral catheter
US8920415B2 (en) 2009-12-16 2014-12-30 Biosense Webster (Israel) Ltd. Catheter with helical electrode
US8608735B2 (en) 2009-12-30 2013-12-17 Biosense Webster (Israel) Ltd. Catheter with arcuate end section
US20110263921A1 (en) 2009-12-31 2011-10-27 Anthony Vrba Patterned Denervation Therapy for Innervated Renal Vasculature
WO2011091069A1 (en) 2010-01-19 2011-07-28 Ardian, Inc. Methods and apparatus for renal neuromodulation via stereotactic radiotherapy
WO2013169741A1 (en) 2012-05-08 2013-11-14 Stein Emily A Agents and devices for affecting nerve function
EP2528649A1 (en) 2010-01-26 2012-12-05 Michael A. Evans Methods, devices, and agents for denervation
EP2550059B1 (en) 2010-03-23 2016-01-06 Boston Scientific Neuromodulation Corporation Helical radial spacing of contacts on a cylindrical lead
AU2011232335A1 (en) 2010-03-24 2012-10-11 Shifamed Holdings, Llc Intravascular tissue disruption
WO2011123689A1 (en) 2010-03-31 2011-10-06 Boston Scientific Scimed, Inc. Guidewire with a flexural rigidity profile
WO2011130534A2 (en) 2010-04-14 2011-10-20 Boston Scientific Scimed, Inc. Renal artery denervation apparatus employing helical shaping arrangement
US8870863B2 (en) 2010-04-26 2014-10-28 Medtronic Ardian Luxembourg S.A.R.L. Catheter apparatuses, systems, and methods for renal neuromodulation
CN103096826B (zh) 2010-04-26 2016-07-20 美敦力阿迪安卢森堡有限公司 用于肾神经调节的导管设备、系统和方法
US10631912B2 (en) 2010-04-30 2020-04-28 Medtronic Xomed, Inc. Interface module for use with nerve monitoring and electrosurgery
US20120123400A1 (en) 2010-05-10 2012-05-17 David Francischelli Methods and devices for controlling energy during ablation
JP5886274B2 (ja) 2010-05-11 2016-03-16 キャスアールエックス リミテッドＣａｔｈｒｘ Ｌｔｄ カテーテル形状解放機構
CN105105844B (zh) 2010-05-12 2017-12-15 施菲姆德控股有限责任公司 小轮廓的电极组件
US20130109987A1 (en) 2011-05-12 2013-05-02 Medical Device Innovations Inc. Method and device for treatment of arrhythmias and other maladies
CN102266245B (zh) 2010-06-04 2015-08-26 心诺普医疗技术（北京）有限公司 灌注式射频消融导管
US8753352B2 (en) 2010-06-25 2014-06-17 Advanced Bionics Ag Tools, systems, and methods for inserting a pre-curved electrode array portion of a lead into a bodily orifice
US9463062B2 (en) 2010-07-30 2016-10-11 Boston Scientific Scimed, Inc. Cooled conductive balloon RF catheter for renal nerve ablation
US20120029512A1 (en) 2010-07-30 2012-02-02 Willard Martin R Balloon with surface electrodes and integral cooling for renal nerve ablation
US20120029505A1 (en) 2010-07-30 2012-02-02 Jenson Mark L Self-Leveling Electrode Sets for Renal Nerve Ablation
US9408661B2 (en) 2010-07-30 2016-08-09 Patrick A. Haverkost RF electrodes on multiple flexible wires for renal nerve ablation
US9084609B2 (en) 2010-07-30 2015-07-21 Boston Scientific Scime, Inc. Spiral balloon catheter for renal nerve ablation
US9155589B2 (en) 2010-07-30 2015-10-13 Boston Scientific Scimed, Inc. Sequential activation RF electrode set for renal nerve ablation
US9358365B2 (en) 2010-07-30 2016-06-07 Boston Scientific Scimed, Inc. Precision electrode movement control for renal nerve ablation
US20120065506A1 (en) 2010-09-10 2012-03-15 Scott Smith Mechanical, Electromechanical, and/or Elastographic Assessment for Renal Nerve Ablation
TWI556849B (zh) 2010-10-21 2016-11-11 美敦力阿福盧森堡公司 用於腎臟神經協調的導管裝置
MX2013004235A (es) 2010-10-25 2013-05-30 Medtronic Ardian Luxembourg Aparatos de cateter que tienen arreglos de multiples electrodos para neuromodulacion renal y sistemas y metodos asociados.
US9028485B2 (en) 2010-11-15 2015-05-12 Boston Scientific Scimed, Inc. Self-expanding cooling electrode for renal nerve ablation
US9089350B2 (en) 2010-11-16 2015-07-28 Boston Scientific Scimed, Inc. Renal denervation catheter with RF electrode and integral contrast dye injection arrangement
CN103327921B (zh) 2010-11-19 2017-02-15 波士顿科学西美德公司 肾神经检测以及消融装置
US9192435B2 (en) 2010-11-22 2015-11-24 Boston Scientific Scimed, Inc. Renal denervation catheter with cooled RF electrode
US9023034B2 (en) 2010-11-22 2015-05-05 Boston Scientific Scimed, Inc. Renal ablation electrode with force-activatable conduction apparatus
EP2645955B1 (en) 2010-12-01 2016-10-26 Boston Scientific Scimed, Inc. Expandable angular vascular electrode for renal nerve ablation
US20120157992A1 (en) 2010-12-15 2012-06-21 Scott Smith Off-wall electrode device for renal nerve ablation
US10016233B2 (en) 2010-12-06 2018-07-10 Biosense Webster (Israel) Ltd. Treatment of atrial fibrillation using high-frequency pacing and ablation of renal nerves
US20120157993A1 (en) 2010-12-15 2012-06-21 Jenson Mark L Bipolar Off-Wall Electrode Device for Renal Nerve Ablation
WO2012086492A1 (ja) 2010-12-21 2012-06-28 テルモ株式会社 バルーンカテーテル及び通電システム
US20120184952A1 (en) 2011-01-19 2012-07-19 Jenson Mark L Low-profile off-wall electrode device for renal nerve ablation
WO2012100211A2 (en) 2011-01-20 2012-07-26 Hansen Medical, Inc. System and method for endoluminal and transluminal therapy
EP2667812A1 (en) 2011-01-28 2013-12-04 Medtronic Ardian Luxembourg S.à.r.l. Ablation catheter equipped with a shape memory material
CA2829045A1 (en) 2011-02-18 2012-08-23 Medivation Technologies, Inc. Compounds and methods for treatment of hypertension
CN103547231B (zh) 2011-03-25 2016-04-13 麦德托尼克消融前沿有限公司 用于电极阵列的冷却系统
WO2012130337A1 (en) 2011-04-01 2012-10-04 Flux Medical N.V. System, device and method for ablation of a vessel's wall from the inside
CN103841913B (zh) 2011-04-08 2016-02-24 柯惠有限合伙公司 用于天然或人造管腔的柔性微波导管
WO2012161875A1 (en) 2011-04-08 2012-11-29 Tyco Healthcare Group Lp Iontophoresis drug delivery system and method for denervation of the renal sympathetic nerve and iontophoretic drug delivery
US9237925B2 (en) 2011-04-22 2016-01-19 Ablative Solutions, Inc. Expandable catheter system for peri-ostial injection and muscle and nerve fiber ablation
WO2012149167A2 (en) 2011-04-26 2012-11-01 Christopher Gerard Kunis Method and device for treatment of hypertension and other maladies
CN102198015B (zh) 2011-05-03 2013-11-06 上海微创电生理医疗科技有限公司 可伸缩螺旋叠环式电极导管
CN102274075A (zh) 2011-05-03 2011-12-14 上海微创电生理医疗科技有限公司 用于热致肾神经调节的多极点状电极导管
US20120323233A1 (en) 2011-05-09 2012-12-20 Cyberheart, Inc. Renovascular treatment device, system, and method for radiosurgically alleviating hypertension
US20120290053A1 (en) 2011-05-11 2012-11-15 St. Jude Medical, Inc. Renal nerve stimulation lead, delivery system, and method
EP2709517B1 (en) 2011-05-18 2017-01-11 St. Jude Medical, Inc. Apparatus for assessing transvascular denervation
US8909316B2 (en) 2011-05-18 2014-12-09 St. Jude Medical, Cardiology Division, Inc. Apparatus and method of assessing transvascular denervation
US20120296232A1 (en) 2011-05-18 2012-11-22 St. Jude Medical, Inc. Method and apparatus of assessing transvascular denervation
WO2013009977A1 (en) 2011-07-12 2013-01-17 David Lambert Device for reducing renal sympathetic nerve activity
WO2013013156A2 (en) 2011-07-20 2013-01-24 Boston Scientific Scimed, Inc. Percutaneous devices and methods to visualize, target and ablate nerves
JP6106669B2 (ja) 2011-07-22 2017-04-05 ボストン サイエンティフィック サイムド，インコーポレイテッドＢｏｓｔｏｎ Ｓｃｉｅｎｔｉｆｉｃ Ｓｃｉｍｅｄ，Ｉｎｃ． ヘリカル・ガイド内に配置可能な神経調節要素を有する神経調節システム
US20130035681A1 (en) 2011-08-04 2013-02-07 Boston Scientific Scimed, Inc. Novel catheter for contiguous rf ablation
US20130274674A1 (en) 2011-08-24 2013-10-17 Ablative Solutions, Inc. Intravascular ablation catheter with precision depth of penetration calibration
US9278196B2 (en) 2011-08-24 2016-03-08 Ablative Solutions, Inc. Expandable catheter system for vessel wall injection and muscle and nerve fiber ablation
US20130165921A1 (en) 2011-08-24 2013-06-27 Boston Scientific Scimed, Inc. Device and methods for nerve modulation
US20130053792A1 (en) 2011-08-24 2013-02-28 Ablative Solutions, Inc. Expandable catheter system for vessel wall injection and muscle and nerve fiber ablation
US9056185B2 (en) 2011-08-24 2015-06-16 Ablative Solutions, Inc. Expandable catheter system for fluid injection into and deep to the wall of a blood vessel
SG2014013957A (en) 2011-08-26 2014-03-28 Symap Holding Ltd System and method for locating and identifying functional nerves innervating wall of arteries and catheters for same
US8702619B2 (en) 2011-08-26 2014-04-22 Symap Holding Limited Mapping sympathetic nerve distribution for renal ablation and catheters for same
WO2013030806A1 (en) 2011-09-01 2013-03-07 Perseus-Biomed Inc. Method and system for tissue modulation
EP2755587B1 (en) 2011-09-14 2018-11-21 Boston Scientific Scimed, Inc. Ablation device with multiple ablation modes
US9427579B2 (en) 2011-09-29 2016-08-30 Pacesetter, Inc. System and method for performing renal denervation verification
JP6146923B2 (ja) 2011-09-30 2017-06-14 コヴィディエン リミテッド パートナーシップ エネルギー送達デバイスおよび使用の方法
US8498686B2 (en) 2011-10-04 2013-07-30 Biosense Webster (Israel), Ltd. Mapping catheter with spiral electrode assembly
US20130090637A1 (en) 2011-10-05 2013-04-11 St. Jude Medical, Inc. Catheter device and method for denervation
US20130090649A1 (en) 2011-10-11 2013-04-11 Boston Scientific Scimed, Inc. Device and methods for renal nerve modulation
EP2765941A1 (en) 2011-10-11 2014-08-20 Boston Scientific Scimed, Inc. Ablation catheter with insulated tip
EP2768563B1 (en) 2011-10-18 2016-11-09 Boston Scientific Scimed, Inc. Deflectable medical devices
US10849879B2 (en) 2011-10-19 2020-12-01 Mercator Medsystems, Inc. Localized modulation of tissues and cells to enhance therapeutic effects including renal denervation
CN102551874B (zh) 2011-10-20 2015-07-22 上海微创电生理医疗科技有限公司 肾动脉射频消融导管
EP2770992A4 (en) 2011-10-26 2015-12-30 Emily A Stein AGENTS, METHODS AND DEVICES FOR AFFECTING NERVOUS FUNCTION
EP2779929A1 (en) 2011-11-15 2014-09-24 Boston Scientific Scimed, Inc. Device and methods for renal nerve modulation monitoring
WO2013077283A1 (ja) 2011-11-21 2013-05-30 国立大学法人大阪大学 腎動脈アブレーション用のカテーテルおよびシステム
US9119632B2 (en) 2011-11-21 2015-09-01 Boston Scientific Scimed, Inc. Deflectable renal nerve ablation catheter
CN202386778U (zh) 2011-11-29 2012-08-22 北京天助畅运医疗技术股份有限公司 射频消融装置
JP6441679B2 (ja) 2011-12-09 2018-12-19 メタベンション インコーポレイテッド 肝臓系の治療的な神経調節
CN102488552B (zh) 2011-12-15 2015-04-15 四川锦江电子科技有限公司 可操控螺旋形电生理导管
US9844405B2 (en) 2011-12-20 2017-12-19 Cardiac Pacemakers, Inc. Method and apparatus for monitoring and ablating nerves
CN202426649U (zh) 2011-12-22 2012-09-12 王涛 环形多点射频消融电极
WO2013101452A1 (en) 2011-12-28 2013-07-04 Boston Scientific Scimed, Inc. Device and methods for nerve modulation using a novel ablation catheter with polymeric ablative elements
US20130172879A1 (en) 2011-12-29 2013-07-04 Boston Scientific Scimed, Inc. Renal nerve modulation medical devices
US20130172878A1 (en) 2011-12-29 2013-07-04 Boston Scientific Scimed, Inc. Device and methods for renal nerve modulation monitoring
US20130172880A1 (en) 2011-12-29 2013-07-04 Boston Scientific Scimed, Inc. Renal nerve modulation devices and methods for renal nerve modulation
US9050106B2 (en) 2011-12-29 2015-06-09 Boston Scientific Scimed, Inc. Off-wall electrode device and methods for nerve modulation
CN104159535A (zh) 2012-01-17 2014-11-19 波士顿科学西美德公司 肾神经调节装置以及用于制造和使用该装置的方法
US8571654B2 (en) 2012-01-17 2013-10-29 Cyberonics, Inc. Vagus nerve neurostimulator with multiple patient-selectable modes for treating chronic cardiac dysfunction
US10470684B2 (en) 2012-01-26 2019-11-12 Autonomix Medical, Inc. Controlled sympathectomy and micro-ablation systems and methods
CN202538132U (zh) 2012-02-06 2012-11-21 北京中孵友信医药科技股份有限公司 蛇形腔内导管
US20130218029A1 (en) 2012-02-16 2013-08-22 Pacesetter, Inc. System and method for assessing renal artery nerve density
US9510777B2 (en) 2012-03-08 2016-12-06 Medtronic Ardian Luxembourg S.A.R.L. Monitoring of neuromodulation using biomarkers
US20130253628A1 (en) 2012-03-22 2013-09-26 Boston Scientific Scimed, Inc. Device and methods for renal nerve modulation
CN202537649U (zh) 2012-04-10 2012-11-21 北京中孵友信医药科技股份有限公司 全域定位腔内导管
US9439598B2 (en) 2012-04-12 2016-09-13 NeuroMedic, Inc. Mapping and ablation of nerves within arteries and tissues
US20130274730A1 (en) 2012-04-12 2013-10-17 Boston Scientific Scimed, Inc. Ablation catheter and methods for nerve modulation
EP2836151B1 (en) 2012-04-13 2016-10-26 Covidien LP Energy delivery device
CN102631240A (zh) 2012-04-13 2012-08-15 上海微创电生理医疗科技有限公司 冷盐水灌注型射频消融导管
CN104203136A (zh) 2012-04-16 2014-12-10 波士顿科学西美德公司 用于流体肾脏神经调制的螺旋管装置
US20130274737A1 (en) 2012-04-16 2013-10-17 Boston Scientific Scimed, Inc. Renal nerve modulation catheter design
US9113929B2 (en) 2012-04-19 2015-08-25 St. Jude Medical, Cardiology Division, Inc. Non-electric field renal denervation electrode
US20130289686A1 (en) 2012-04-29 2013-10-31 Synecor Llc Intravascular electrode arrays for neuromodulation
US10660703B2 (en) 2012-05-08 2020-05-26 Boston Scientific Scimed, Inc. Renal nerve modulation devices
US9717555B2 (en) 2012-05-14 2017-08-01 Biosense Webster (Israel), Ltd. Catheter with helical end section for vessel ablation
US9439722B2 (en) 2012-05-09 2016-09-13 Biosense Webster (Israel) Ltd. Ablation targeting nerves in or near the inferior vena cava and/or abdominal aorta for treatment of hypertension
US11357447B2 (en) 2012-05-31 2022-06-14 Sonivie Ltd. Method and/or apparatus for measuring renal denervation effectiveness
US20150151077A1 (en) 2012-06-13 2015-06-04 Douglas C. Harrington Devices And Methods For Renal Denervation
CN102772249B (zh) 2012-06-19 2015-01-21 深圳市惠泰医疗器械有限公司 肾动脉轨道射频消融电极导管
CN102688093B (zh) 2012-06-20 2014-08-27 深圳市惠泰医疗器械有限公司 肾动脉冷盐水射频消融可控电极导管
US9295842B2 (en) 2012-07-05 2016-03-29 Mc10, Inc. Catheter or guidewire device including flow sensing and use thereof
US9168094B2 (en) 2012-07-05 2015-10-27 Mc10, Inc. Catheter device including flow sensing
CN102743225B (zh) 2012-07-18 2014-04-02 深圳市惠泰医疗器械有限公司 肾动脉射频消融可控电极导管
WO2014031165A1 (en) 2012-08-22 2014-02-27 Medivation Technologies, Inc. Compounds and methods of treating diabetes
CN203138452U (zh) 2012-08-24 2013-08-21 苏州信迈医疗器械有限公司 一种能够定位或识别位于血管壁内或外膜上的神经的仪器
US10321946B2 (en) 2012-08-24 2019-06-18 Boston Scientific Scimed, Inc. Renal nerve modulation devices with weeping RF ablation balloons
WO2014036160A2 (en) 2012-08-28 2014-03-06 Boston Scientific Scimed, Inc. Renal nerve modulation and ablation catheter electrode design
CN104703556B (zh) 2012-08-28 2017-05-24 波士顿科学西美德公司 具有可动虚拟电极的肾脏射频消融系统及其相关使用方法
CN102885648B (zh) 2012-08-29 2015-03-18 中国人民解放军第三军医大学第一附属医院 肾脏去交感神经消融导管系统
WO2014056460A1 (zh) 2012-08-29 2014-04-17 第三军医大学第一附属医院 肾脏去交感神经多功能消融导管系统
CN202843784U (zh) 2012-08-29 2013-04-03 中国人民解放军第三军医大学第一附属医院 肾脏去交感神经消融导管系统
CN102908189B (zh) 2012-08-29 2015-04-08 中国人民解放军第三军医大学第一附属医院 肾脏去交感神经多功能消融导管系统
CN102908188B (zh) 2012-08-29 2015-04-08 中国人民解放军第三军医大学第一附属医院 肾脏去交感神经射频消融导管系统
CN102885649B (zh) 2012-08-29 2015-01-21 中国人民解放军第三军医大学第一附属医院 肾脏去交感神经射频线控消融导管系统
CN202761434U (zh) 2012-08-29 2013-03-06 中国人民解放军第三军医大学第一附属医院 肾脏去交感神经多功能消融导管系统
TWI498101B (zh) 2012-08-30 2015-09-01 Univ Nat Chiao Tung 神經纖維分佈之分析方法及標準化誘發復合動作電位之量測方法
JP2014054430A (ja) 2012-09-13 2014-03-27 Nippon Koden Corp カテーテル
CN104869930B (zh) 2012-10-10 2020-12-25 波士顿科学国际有限公司 肾神经调制装置和方法
US9770593B2 (en) 2012-11-05 2017-09-26 Pythagoras Medical Ltd. Patient selection using a transluminally-applied electric current
CN104902836B (zh) 2012-11-05 2017-08-08 毕达哥拉斯医疗有限公司 受控组织消融
US20140316496A1 (en) 2012-11-21 2014-10-23 NeuroTronik IP Holding (Jersey) Limited Intravascular Electrode Arrays for Neuromodulation
US20140163360A1 (en) 2012-12-07 2014-06-12 Boston Scientific Scimed, Inc. Irrigated catheter
CN104837434A (zh) 2012-12-10 2015-08-12 皇家飞利浦有限公司 用于肾脏去神经的数字标尺和标线
WO2014091401A2 (en) 2012-12-10 2014-06-19 Perseus-Biomed Inc. Dynamic denervation procedures and systems for the implementation thereof
US10028764B2 (en) 2013-02-21 2018-07-24 Boston Scientific Scimed, Inc. Ablation catheter with wireless temperature sensor
US10195467B2 (en) 2013-02-21 2019-02-05 Boston Scientific Scimed, Inc. Ablation catheter system with wireless radio frequency temperature sensor
US20140249524A1 (en) 2013-03-01 2014-09-04 Boston Scientific Scimed, Inc. System and method for performing renal nerve modulation
US20140246465A1 (en) 2013-03-03 2014-09-04 Joan Darnell Peterson Fish n stow
US20140303617A1 (en) 2013-03-05 2014-10-09 Neuro Ablation, Inc. Intravascular nerve ablation devices & methods
WO2014163987A1 (en) 2013-03-11 2014-10-09 Boston Scientific Scimed, Inc. Medical devices for modulating nerves
US9693821B2 (en) 2013-03-11 2017-07-04 Boston Scientific Scimed, Inc. Medical devices for modulating nerves
US20140276755A1 (en) 2013-03-12 2014-09-18 Boston Scientific Scimed, Inc. Medical systems and methods for modulating nerves
US9510902B2 (en) 2013-03-13 2016-12-06 St. Jude Medical, Cardiology Division, Inc. Ablation catheters and systems including rotational monitoring means
US9808311B2 (en) 2013-03-13 2017-11-07 Boston Scientific Scimed, Inc. Deflectable medical devices
US9131982B2 (en) 2013-03-14 2015-09-15 St. Jude Medical, Cardiology Division, Inc. Mediguide-enabled renal denervation system for ensuring wall contact and mapping lesion locations
US8876813B2 (en) 2013-03-14 2014-11-04 St. Jude Medical, Inc. Methods, systems, and apparatus for neural signal detection
US10265122B2 (en) 2013-03-15 2019-04-23 Boston Scientific Scimed, Inc. Nerve ablation devices and related methods of use
US9186212B2 (en) 2013-03-15 2015-11-17 St. Jude Medical, Cardiology Division, Inc. Feedback systems and methods utilizing two or more sites along denervation catheter
US9333113B2 (en) 2013-03-15 2016-05-10 Abbott Cardiovascular Systems Inc. System and method for denervation
US9974477B2 (en) 2013-03-15 2018-05-22 St. Jude Medical, Cardiology Division, Inc. Quantification of renal denervation via alterations in renal blood flow pre/post ablation
US20140276767A1 (en) 2013-03-15 2014-09-18 St. Jude Medical, Cardiology Division, Inc. Ablation system, methods, and controllers
WO2014149690A2 (en) 2013-03-15 2014-09-25 Boston Scientific Scimed, Inc. Medical devices and methods for treatment of hypertension that utilize impedance compensation
EP2967734B1 (en) 2013-03-15 2019-05-15 Boston Scientific Scimed, Inc. Methods and apparatuses for remodeling tissue of or adjacent to a body passage
EP3345564A1 (en) 2013-03-15 2018-07-11 St. Jude Medical, Cardiology Division, Inc. Multi-electrode ablation system with a controller for determining a thermal gain of each electrode
US9179973B2 (en) 2013-03-15 2015-11-10 St. Jude Medical, Cardiology Division, Inc. Feedback systems and methods for renal denervation utilizing balloon catheter
WO2014162660A1 (ja) 2013-04-01 2014-10-09 テルモ株式会社 モニタリングデバイス及びモニタリングデバイスキット
EP2991717A4 (en) 2013-05-02 2016-12-07 Douglas C Harrington DEVICES AND METHODS FOR DETECTION AND TREATMENT OF AORTICO-RENAL GANGLION
WO2014176785A1 (zh) 2013-05-03 2014-11-06 上海安通医疗科技有限公司 一种用于调节神经的装置
EP2994068A2 (en) 2013-05-08 2016-03-16 Boston Scientific Scimed, Inc. Systems and methods for temperature monitoring and control during an ablation procedure
WO2014197625A1 (en) 2013-06-05 2014-12-11 Metavention, Inc. Modulation of targeted nerve fibers
AU2014284558B2 (en) 2013-07-01 2017-08-17 Boston Scientific Scimed, Inc. Medical devices for renal nerve ablation
US20150025524A1 (en) 2013-07-18 2015-01-22 St. Jude Medical, Cardiology Division, Inc. Renal denervation monitoring and feedback apparatus, system and method
CN105682594B (zh) 2013-07-19 2018-06-22 波士顿科学国际有限公司 螺旋双极电极肾脏去神经支配气囊
US9913684B2 (en) 2013-08-23 2018-03-13 Oscor Inc. Steerable ablation catheter for renal denervation
US20150126992A1 (en) 2013-11-05 2015-05-07 Mogul Enterprises, Inc Helical DeNervation Ablation Catheter Apparatus
JP2015119831A (ja) 2013-12-24 2015-07-02 テルモ株式会社 アブレーションカテーテル
US20150223866A1 (en) 2014-02-07 2015-08-13 Verve Medical, Inc. Methods and systems for ablation of the renal pelvis
US20150223877A1 (en) 2014-02-12 2015-08-13 Perseus-Biomed Inc. Methods and systems for treating nerve structures
US10478249B2 (en) 2014-05-07 2019-11-19 Pythagoras Medical Ltd. Controlled tissue ablation techniques
CN105167840A (zh) 2014-06-20 2015-12-23 上海安通医疗科技有限公司 一种多电极肾动脉射频消融导管
CN105326562A (zh) 2014-06-24 2016-02-17 上海安通医疗科技有限公司 一种用于调节肾神经的导管装置
JP2016086999A (ja) 2014-10-31 2016-05-23 テルモ株式会社 アブレーションカテーテル
JP2018500085A (ja) 2014-12-17 2018-01-11 キャスアールエックス リミテッドＣａｔｈｒｘ Ｌｔｄ 改良型カテーテル及びその製造方法
US9737361B2 (en) 2014-12-18 2017-08-22 Abbott Cardiovascular Systems Inc. System and method for a catheter
US9795780B2 (en) 2014-12-18 2017-10-24 Abbott Cardiovascular Systems Inc. System for denervation
CN205433879U (zh) 2015-12-08 2016-08-10 上海安通医疗科技有限公司 一种肾动脉射频消融导管
CN205433878U (zh) 2015-12-08 2016-08-10 上海安通医疗科技有限公司 一种肾动脉射频消融导管

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5944710A (en) * 1996-06-24 1999-08-31 Genetronics, Inc. Electroporation-mediated intravascular delivery
US6219577B1 (en) * 1998-04-14 2001-04-17 Global Vascular Concepts, Inc. Iontophoresis, electroporation and combination catheters for local drug delivery to arteries and other body tissues

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103826694A (zh) * 2011-09-30 2014-05-28 柯惠有限合伙公司 能量传递装置以及使用方法
US9808304B2 (en) 2011-10-27 2017-11-07 Medtronic Cryocath Lp Cryogenic balloon device with electroporation treatment region

Also Published As

Publication number Publication date
EP2561905B1 (en) 2014-06-04
EP3056242B1 (en) 2018-07-04
US20070265687A1 (en) 2007-11-15
EP2561904A8 (en) 2013-04-03
EP2329859A1 (en) 2011-06-08
DE202005022061U1 (de) 2012-11-28
US20050288730A1 (en) 2005-12-29
ES2570927T3 (es) 2016-05-23
ES2534535T3 (es) 2015-04-23
JP2012135630A (ja) 2012-07-19
JP5646135B2 (ja) 2014-12-24
CN101084038A (zh) 2007-12-05
US20130012866A1 (en) 2013-01-10
JP2012110738A (ja) 2012-06-14
DE202005022059U1 (de) 2012-11-28
US20140018723A1 (en) 2014-01-16
US9289255B2 (en) 2016-03-22
EP2868344B1 (en) 2017-08-09
EP3939531A1 (en) 2022-01-19
ES2684499T3 (es) 2018-10-03
CA2583463C (en) 2013-04-30
JP5952356B2 (ja) 2016-07-13
EP2457614B1 (en) 2017-04-12
EP2561902A1 (en) 2013-02-27
EP1802370A2 (en) 2007-07-04
EP2561905A1 (en) 2013-02-27
US9675413B2 (en) 2017-06-13
JP2012143573A (ja) 2012-08-02
WO2006041881A2 (en) 2006-04-20
US8548600B2 (en) 2013-10-01
US20190232055A1 (en) 2019-08-01
PL2561905T3 (pl) 2015-01-30
EP2572753A2 (en) 2013-03-27
DE202005022096U1 (de) 2013-07-18
US7653438B2 (en) 2010-01-26
JP2012110748A (ja) 2012-06-14
EP1802370A4 (en) 2009-10-21
US20160296279A1 (en) 2016-10-13
US20140081259A1 (en) 2014-03-20
CN101972513A (zh) 2011-02-16
US20180229033A1 (en) 2018-08-16
ES2691040T3 (es) 2018-11-23
CN101940816A (zh) 2011-01-12
EP2570154A3 (en) 2013-04-03
DE202005022083U1 (de) 2013-03-26
US8934978B2 (en) 2015-01-13
EP2457615B1 (en) 2014-12-17
DE202005022060U1 (de) 2012-11-28
EP2561903A1 (en) 2013-02-27
ES2531888T3 (es) 2015-03-20
JP2012106081A (ja) 2012-06-07
ES2538708T3 (es) 2015-06-23
US20170326363A1 (en) 2017-11-16
EP3939531B1 (en) 2024-03-13
US11033328B2 (en) 2021-06-15
EP2561902B1 (en) 2014-12-03
EP2457615A1 (en) 2012-05-30
EP2457614A1 (en) 2012-05-30
DE202005022123U1 (de) 2014-03-27
US20100222851A1 (en) 2010-09-02
EP3159037A1 (en) 2017-04-26
US8768470B2 (en) 2014-07-01
EP2868344A1 (en) 2015-05-06
JP2008515544A (ja) 2008-05-15
US20140058377A1 (en) 2014-02-27
ATE494039T1 (de) 2011-01-15
ES2743974T3 (es) 2020-02-21
EP2495012A1 (en) 2012-09-05
EP2561905A8 (en) 2013-04-03
CA2583463A1 (en) 2006-04-20
JP2015013185A (ja) 2015-01-22
MX2007004238A (es) 2007-08-03
WO2006041881A3 (en) 2007-03-29
EP1802370B1 (en) 2011-01-05
EP2561904A1 (en) 2013-02-27
ES2740836T3 (es) 2020-02-06
WO2006041881B1 (en) 2007-05-10
US20150238252A1 (en) 2015-08-27
EP2561902A8 (en) 2013-04-03
EP2561904B1 (en) 2016-02-10
EP3056242A1 (en) 2016-08-17
ES2532077T3 (es) 2015-03-24
EP2570154A2 (en) 2013-03-20
CN101940816B (zh) 2012-12-26
DE602005025789D1 (de) 2011-02-17
US9125661B2 (en) 2015-09-08
EP2561903B1 (en) 2018-05-23
CN101972513B (zh) 2017-06-23
EP3132825B1 (en) 2019-05-15
US20130116685A1 (en) 2013-05-09
US8852163B2 (en) 2014-10-07
EP3446747B1 (en) 2021-12-01
EP3108930B1 (en) 2019-05-15
CN101940815A (zh) 2011-01-12
US20210298826A1 (en) 2021-09-30
US20140228739A1 (en) 2014-08-14
EP2570154B1 (en) 2015-03-04
EP2572753A3 (en) 2013-05-22
US20160220305A1 (en) 2016-08-04
ES2494119T3 (es) 2014-09-15
US10245429B2 (en) 2019-04-02
DE202005022057U1 (de) 2012-11-13
EP3108930A1 (en) 2016-12-28
EP3132825A1 (en) 2017-02-22
DE202005022058U1 (de) 2012-11-13
EP2561903A8 (en) 2013-04-03
EP3446747A1 (en) 2019-02-27
EP2572753B1 (en) 2015-01-28

Similar Documents

Publication Publication Date Title
CN101084038B (zh) 肾神经调节的装置
CN101600471B (zh) 肾神经调节的方法和装置
CN101443072B (zh) 双侧肾神经调制的方法和装置

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
ASS Succession or assignment of patent right

Owner name: MEDTRONIC AF LUXEMBOURG S. A. R. L.

Free format text: FORMER OWNER: MEDTRONIC ARDIAN LUXEMBOURG S. A. R. L.

Effective date: 20121220

Owner name: MEDTRONIC ARDIAN LUXEMBOURG S. A. R. L.

Free format text: FORMER OWNER: MEDTRONIC ARDIAN S. A. R. L.

Effective date: 20121220

C41 Transfer of patent application or patent right or utility model
C56 Change in the name or address of the patentee

Owner name: MEDTRONIC ARDIAN S. A. R. L.

Free format text: FORMER NAME: ARDIAN INC.

CP03 Change of name, title or address

Address after: Delaware

Patentee after: Medtronic Adian LLC

Address before: California, USA

Patentee before: ARDIAN, Inc.

TR01 Transfer of patent right

Effective date of registration: 20121220

Address after: Luxemburg Luxemburg

Patentee after: Ardian, Inc.

Address before: Luxemburg Luxemburg

Patentee before: Medtronic Adian Luxemburg Co.

Effective date of registration: 20121220

Address after: Luxemburg Luxemburg

Patentee after: Medtronic Adian Luxemburg Co.

Address before: Delaware

Patentee before: Medtronic Adian LLC

EE01 Entry into force of recordation of patent licensing contract

Application publication date: 20071205

Assignee: MEDTRONIC, Inc.

Assignor: Ardian, Inc.

Contract record no.: 2017990000083

Denomination of invention: Apparatus for renal neuromodulation

Granted publication date: 20101117

License type: Common License

Record date: 20170314

EE01 Entry into force of recordation of patent licensing contract