CN102683878A - MRI (magnetic resonance imaging) magnetic signal enhancing device - Google Patents
MRI (magnetic resonance imaging) magnetic signal enhancing device Download PDFInfo
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- CN102683878A CN102683878A CN2012101330461A CN201210133046A CN102683878A CN 102683878 A CN102683878 A CN 102683878A CN 2012101330461 A CN2012101330461 A CN 2012101330461A CN 201210133046 A CN201210133046 A CN 201210133046A CN 102683878 A CN102683878 A CN 102683878A
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Abstract
The invention provides an MRI (magnetic resonance imaging) magnetic signal enhancing device which comprises a shell and at least one layer of negative magnetic permeability metamaterials arranged in the shell, wherein the negative magnetic permeability metamaterials are specially designed low-frequency negative permeability metamaterials. When the magnetic permeability of the negative magnetic permeability metamaterials of the MRI magnetic signal enhancing device is negative and when the resonance frequency is similar to the working frequency of an MRI device, the negative magnetic permeability metamaterials can respond to a receiving coil of the MRI device, a magnetic signal of the receiving coil is enhanced, so that the imaging quality of the MRI device is improved, the receiving coil of the MRI device does not need to be adjacent to a portion to be detected, and the comfortableness of the MRI device in use is improved.
Description
Technical field
The present invention relates to the MRI field, relate to a kind of MRI magnetic signal enhance device particularly.
Background technology
The principle of nulcear magnetic resonance (NMR) (MRI) imaging system is to utilize coil to remove to detect the radio wave pulses energy that nuclear spin absorbs and launches, and this coil is being gone back simultaneously as transmitting coil as receiving coil sometimes.Under the help of radio wave pulses energy, the Magnetic resonance imaging scanner can the position patient body in a very little point, confirm that then this is the tissue of which kind of type.The magnetic resonance imaging machine device adopts the radio frequency pulse specific to hydrogen atom.The system pilot pulse is aimed at the body region that institute will check, and causes this regional proton to absorb they are rotated or the required energy of precession with different directions.This is NMR imaging device " resonance " part.Radio frequency pulse forces their (referring to a pair of or two pairs of unmatched protons unnecessary in each 1,000,000 proton) under CF, to be rotated according to specific direction.The CF that causes resonance is called as Rameau that frequency, and this value is to calculate according to the magnetic field intensity of the particular organization that will form images and main field to draw.Radio frequency pulse utilizes a coil to provide usually, and this coil is called transmitting coil.The necessary quite near-earth of the receiving coil of existing Magnetic resonance imaging equipment is near detected part, to obtain the magnetic signal that is discharged by detected part.The definition and the main field strength of MRI imaging device are proportionate, and the main magnetic field magnet system is the major part of MRI imaging device, in order to promote the image quality of MRI imaging system, generally need to change whole MRI imaging device, and cost is very high.
Ultra material is meant artificial composite structure or the composite material that some have the not available extraordinary physical property of natural material.Structurally ordered design through on the key physical yardstick of material can break through the restriction of some apparent natural law, thereby obtains to exceed the meta-materials function of the intrinsic common character of nature.The character of ultra material and function mainly come from its inner structure but not constitute their material.At present; The geometry of the artificial micro-structural of existing metal is the perhaps open annular of similar " recessed " font as shown in Figure 1 of " worker " font; But this structure all can not realize magnetic permeability μ and be significantly less than 0 or ultra material resonances frequency is reduced, and can not realize isotropism, has only the artificial micro-structural of metal that has the special geometric figure through design; Could make this artificial electromagnetic material in special frequency, reach magnetic permeability μ value, and have lower resonance frequency less than 0.
At present, international community is to the existing a large amount of research in magnetic permeability aspect, and wherein the research for positive magnetic permeability has been tending towards ripe; Research for the ultra material of negative magnetoconductivity is the focus of studying both at home and abroad now, and negative magnetoconductivity has the quantum polarization, can produce polarization to incident wave; Therefore sphere of action is very big, and like the mr imaging technique in the medical imaging field, negative magnetic-inductive capacity material can be strengthened electromagnetic imaging effect; Negative magnetic-inductive capacity material is also playing an important role aspect the lens research in addition; In the engineering field, magnetic permeability all is meant relative permeability usually, is the absolute permeability μ and the magnetic constant μ of material
0The ratio of (claiming permeability of vacuum again), μ r=μ/μ
0, dimensionless number.Usually " relatively " two words and symbol subscript r are removed.Magnetic permeability is to represent that material receives magnetizing field H and does the time spent, and inner true magnetic field is with respect to the degree of increase (μ＞1) or the minimizing (μ＜1) of H.So far in the already present material of finding of nature, μ is generally greater than 0.
Summary of the invention
Technical problem to be solved by this invention is: a kind of MRI magnetic signal enhance device is provided; This MRI magnetic signal enhance device is the ultra material of negative magnetoconductivity; The image quality of Contrast-enhanced MRI imaging device, simultaneously, the image quality of MRI imaging device strengthens; Can make the receiving coil of MRI imaging device increase the comfortableness that the MRI imaging device uses near detected part.
The present invention for realizing the technical scheme that goal of the invention adopts is: a kind of MRI magnetic signal enhance device is provided; This MRI magnetic signal enhance device comprises shell and the ultra material of the negative magnetoconductivity of one deck at least in the enclosure is set; The ultra material of negative magnetoconductivity comprises that substrate and a plurality of cyclic array are arranged in the first artificial micro-structural and the second artificial micro-structural of substrate two sides; The first artificial micro-structural links to each other through a metallic vias with the second artificial micro-structural; The first artificial micro-structural and the second artificial micro-structural are square torus; Square torus winding turns is 3 circles, and the first artificial micro-structural and the second artificial micro-structural are of a size of 19.5mm * 19.5mm, and substrate is placed with the magnetic signal receiving coil of the two sides of the first artificial micro-structural and the second artificial micro-structural perpendicular to the MRI imaging device.
Preferably, MRI magnetic signal enhance device is of a size of 300mm * 300mm.
Preferably, the field intensity of MRI imaging device is 1.5T.
Preferably, the live width of the first artificial micro-structural and the second artificial micro-structural is 0.50-1.50mm.
Preferably, the distance between centers of tracks of the first artificial micro-structural and the second artificial micro-structural is 0.05-0.15mm.
Preferably, the line thickness of the first artificial micro-structural and the second artificial micro-structural is 0.03-0.05mm.
Preferably, substrate comprises first substrate and second substrate, and first substrate and second substrate are FR-4 organic polymer substrate or ceramic substrate.
Preferably, first substrate thickness is 0.15-0.20mm.
Preferably, the thickness of second substrate is 0.05-0.10mm.
Preferably, the aperture of metallic vias is 0.50-0.90mm.
The invention has the beneficial effects as follows: a kind of MRI magnetic signal enhance device is provided; MRI magnetic signal enhance device utilizes the magnetic permeability of the ultra material of negative magnetoconductivity for negative this characteristic, reaches the effect that signal strengthens, and makes MRI imaging device imaging effect better; Simultaneously; The image quality of MRI imaging device strengthens, and can make the receiving coil of MRI imaging device increase MRI imaging device comfort near detected part.
Description of drawings
Fig. 1, the artificial micro-structural sketch map of the ultra material of prior art negative magnetoconductivity;
Fig. 2, MRI magnetic signal enhance device sketch map;
Fig. 3, negative magnetoconductivity metamaterial structure sketch map of the present invention;
Fig. 4, the present invention's first artificial micro-structural sketch map;
Fig. 5, the present invention's second artificial micro-structural sketch map;
Fig. 6, the ultra material simulated effect of prior art negative magnetoconductivity sketch map;
Fig. 7, the ultra material simulated effect of negative magnetoconductivity of the present invention sketch map;
Fig. 8, the spherical moisture film sagittal plane of no MRI magnetic signal enhance device design sketch;
Fig. 9 has the spherical moisture film sagittal plane of MRI magnetic signal enhance device design sketch;
Figure 10, the no MRI magnetic signal enhance device animal coronal-plane design sketch that exsomatizes;
Figure 11 has the MRI magnetic signal enhance device animal coronal-plane design sketch that exsomatizes;
Figure 12, MRI magnetic signal enhance device-receiving coil-detected part position view;
Among the figure, the ultra material of 10 negative magnetoconductivities, 12 shells, 1 first artificial micro-structural, 2 second artificial micro-structurals, 3 metallic vias, 4 first substrates, 5 second substrates, 6 syndetons, 101MRI magnetic signal enhance device, 102 receiving coils, 103 detected part.
Embodiment
Below in conjunction with accompanying drawing and embodiment the present invention is elaborated.
Shown in Figure 1 is the artificial micro-structural of open annular of similar " recessed " of the prior art font; The artificial micro-structural of this shape can make ultra material magnetic permeability for negative; But the resonance frequency that reaches negative magnetoconductivity is higher; Show that like Fig. 6 above-mentioned artificial micro-structural shape reaches magnetic permeability and surpasses 350MHz for negative resonance frequency.
Fig. 2 is MRI magnetic signal enhance device 101 sketch mapes, and MRI magnetic signal enhance device 101 of the present invention comprises shell 12 and is arranged on the ultra material 10 of the negative magnetoconductivity of one deck at least in the shell 12.Should be appreciated that shell 12 of the present invention plays the effect of support, the ultra material 10 of protection internal layer negative magnetoconductivity, when measuring some privileged sites such as shank, neck, can carry out conformal design, be convenient to the user and use according to concrete needs to shell 12 and ultra material 10.If there is the ultra material 10 of two-layer above negative magnetoconductivity shell 12 inside, can be with its coaxial secured in parallel.
Fig. 3 shows negative magnetoconductivity metamaterial structure sketch map of the present invention; The ultra material of negative magnetoconductivity of the present invention comprises that the first artificial micro-structural 1 and second artificial micro-structural 2, the first artificial micro-structurals 1 that substrate and a plurality of cyclic array are arranged in the substrate both sides link to each other through a metallic vias 3 with the second artificial micro-structural 2.The first artificial micro-structural 1 is connected through metallic vias 3 with the second artificial micro-structural 2; The aperture of metallic vias 3 is 0.50-0.90mm; The connected mode of the first artificial micro-structural 1 and the second artificial micro-structural 2 is following: on the first artificial micro-structural 1 and the second artificial micro-structural 2 syndeton 6 is arranged all; Two syndetons 6 link to each other through metallic vias 3, and syndeton 6 is an electric conducting material, like metallic copper, argent, conductive plastics etc.
Be to be understood that; The first artificial micro-structural 1 and the second artificial micro-structural 2 are on the surface of substrate 4 periodically arranges; As shown in Figure 3, for example rectangular array arrangement promptly is row, serves as that row ground is arranged with the y direction perpendicular to the x direction with an x direction; And each line space, each column pitch equate respectively, even line space equals column pitch and all can.Preferred line space, column pitch be not more than the incident electromagnetic wave that will respond wavelength 1/4th; Promptly for example operational environment is that wavelength is the electromagnetic wave of λ; Needing ultra material is to present negative magnetoconductivity to this electromagnetic electromagnetic property; When then designing artificial micro-structural above-mentioned line space, column pitch are selected to be not more than quarter-wave, be preferably 1/10th wavelength.
Fig. 4 is that the present invention's first artificial micro-structural sketch map, Fig. 5 are the present invention's second artificial micro-structural sketch map, and the first artificial micro-structural 1 and the second artificial micro-structural 2 are square torus, like Fig. 4, shown in Figure 5; Square torus is generally metal wire; Like copper cash, silver-colored line, copper alloy, or even gold thread, also can be by at least two kinds of metal alloys; Or even nonmetallic electric conducting material, like conductive plastics, ITO (indium tin oxide), CNT, graphite etc.The square torus winding turns of the present invention is 3 circles, and the first artificial micro-structural 1 and the second artificial micro-structural 2 are of a size of 19.5mm * 19.5mm.
Be to be understood that; The live width of the present invention's first artificial micro-structural 1 and the second artificial micro-structural 2 is 0.05-0.15mm; The distance between centers of tracks of the first artificial micro-structural 1 and the second artificial micro-structural 2 is 0.03-0.05mm, and the line thickness of the first artificial micro-structural 1 and the second artificial micro-structural 2 is 0.05-0.15mm.
Should be appreciated that the circle of this paper, be meant as shown in Figure 4ly, a bit be polar limit O with ring-shaped inner part that split ring resonator was surrounded
e, leave limit O in split ring resonator two distal points
eNear distal point line to the extreme is this polar pole axis, and getting is positive direction counterclockwise, then uses polar coordinates (ρ successively along the every bit on the split ring resonator
e, represent that θ) every one 360 degree is a circle, up to reach split ring resonator from limit another distal point far away.
Should be appreciated that substrate is FR-4 organic polymer substrate or ceramic substrate, the thickness of first substrate 4 is 0.15-0.20mm, and the thickness of second substrate 5 is 0.05-0.10mm.
Fig. 7 is the ultra material simulated effect of negative magnetoconductivity of the present invention sketch map, and the simulation software that simulation software and Fig. 6 use is CST MICROWAVE STUDIO 2010, and simulation parameter is: square torus adopts copper cash; Copper cash live width 1mm, copper cash distance between centers of tracks 0.1mm, copper cash line thickness 0.035mm; First substrate 4 is a ceramic substrate, and its thickness is 0.164mm, and second substrate 5 is the FR-4 epoxy resin base plate; Its thickness is 0.06mm, and the first artificial micro-structural 1 and the second artificial micro-structural 2 are of a size of 19.5mm * 19.5mm, coiling 3 circles; The aperture of metallic vias 3 is 0.7mm, can be known by simulation result, and the ultra material of negative magnetoconductivity of the present invention realizes that magnetic permeability is that-1 resonance frequency is at 63.6MHz; Compared with prior art; Greatly reduce the resonance frequency of the ultra material of negative magnetoconductivity, MRI system frequency and the said frequencies of 1.5T are approaching, thereby resonance frequency is the image quality that the MRI magnetic signal enhance device 101 of 63.6MHz can improve the MRI imaging device of 1.5T.
Based on the ultra material of above-mentioned low resonant frequency negative magnetoconductivity; Process MRI magnetic signal enhance device 101 as shown in Figure 2; The substrate of the ultra material of MRI magnetic signal enhance device 101 inner negative magnetoconductivities is placed with the magnetic signal receiving coil 102 of the two sides of the first artificial micro-structural 1 and the second artificial micro-structural 2 perpendicular to the MRI imaging device; When the ultra material of negative magnetoconductivity in the MRI magnetic signal enhance device 101 at magnetic permeability when negative, and under the resonance frequency situation identical with the MRI operating frequency, the receiving coil generation of ultra material of negative magnetoconductivity and MRI imaging device responds; Strengthen the magnetic signal of receiving coil, and then the image quality of Contrast-enhanced MRI imaging device.
Be the imaging effect that confirms that MRI magnetic signal enhance device 101 of the present invention can the Contrast-enhanced MRI imaging device, done following experiment:
Test the experiment of 1 moisture film
A. spherical moisture film being placed field intensity is between the MRI imaging device receiving coil 102 and transmitting coil of 1.5T; Because spherical moisture film bottom is near receiving coil 102; The spherical moisture film sagittal view that obtains evenly brightens from top to bottom; The average gray value of above-mentioned spherical moisture film sagittal view is 78.95, and average SNR value (signal to noise ratio) is 0.147, referring to Fig. 8.
B. MRI magnetic signal enhance device 101 of the present invention is placed spherical moisture film left hand position; Referring to Figure 12; The substrate that is the ultra material of MRI magnetic signal enhance device 101 inner negative magnetoconductivities is placed with the magnetic signal receiving coil 102 of the two sides of the first artificial micro-structural 1 and the second artificial micro-structural 2 perpendicular to the MRI imaging device, and spherical moisture film (detected part 103) places between MRI magnetic signal enhance device 101 and the receiving coil 102.As shown in Figure 9, the image brightness of the spherical moisture film sagittal view that obtains obviously improves, and recording its average gray value is 137.39, and the average SNR value is 0.173.
Hence one can see that, and the average gray value that adds the spherical moisture film sagittal view that obtains after the MRI magnetic signal enhance device 101 of the present invention has increased by 74%, and the average SNR value has increased by 17.9%.
A. the animal of animal isolated experiment selection is exsomatized and is fresh pig's feet; Animal exsomatized, and to place field intensity be between the receiving coil 102 and transmitting coil of MRI imaging device of 1.5T; It is shown in figure 10 to obtain the stripped coronal-plane design sketch of animal; Recording its average gray value is 22.20, and standard deviation value is 30.81.
B. MRI magnetic signal enhance device 101 is placed the animal left hand position of exsomatizing; The substrate of the ultra material of MRI magnetic signal enhance device 101 inner negative magnetoconductivities is placed with the magnetic signal receiving coil 102 of the two sides of the first artificial micro-structural 1 and the second artificial micro-structural 2 perpendicular to the MRI imaging device; Animal stripped (detected part 103) places between MRI magnetic signal enhance device 101 and the receiving coil 102, and other conditions are constant, and it is more clear, bright to record the stripped coronal-plane design sketch of animal; Muscle, bone texture that animal is exsomatized are more clear; Its average gray value is 32.41, and standard deviation value is 46.72, referring to Figure 11.
Hence one can see that, and the average gray value of the stripped coronal-plane design sketch of animal has increased by 46.72% than no MRI magnetic signal enhance device, and standard deviation value has increased by 51%.The image quality of MRI imaging device improves greatly, and the image quality of MRI imaging device improves, and can make the receiving coil 102 of MRI imaging device needn't be near detected part, the comfortableness when the Contrast-enhanced MRI imaging device uses.
The foregoing description among the present invention has only been done exemplary description, and those skilled in the art can carry out various modifications to the present invention under the situation that does not break away from the spirit and scope of the present invention after reading present patent application.
Claims (10)
1. MRI magnetic signal enhance device; It is characterized in that; Said MRI magnetic signal enhance device comprises shell and the ultra material of the negative magnetoconductivity of one deck at least in the enclosure is set; The ultra material of said negative magnetoconductivity comprises that substrate and a plurality of cyclic array are arranged in the first artificial micro-structural and the second artificial micro-structural of substrate two sides; The said first artificial micro-structural links to each other through a metallic vias with the second artificial micro-structural, and the said first artificial micro-structural and the second artificial micro-structural are square torus, and said square torus winding turns is 3 circles; The said first artificial micro-structural and the second artificial micro-structural are of a size of 19.5mm * 19.5mm, and said substrate is placed with the magnetic signal receiving coil of the two sides of the said first artificial micro-structural and the second artificial micro-structural perpendicular to the MRI imaging device.
2. MRI magnetic signal enhance device according to claim 1 is characterized in that, said MRI magnetic signal enhance device is of a size of 300mm * 300mm.
3. MRI magnetic signal enhance device according to claim 1 is characterized in that the field intensity of said MRI imaging device is 1.5T.
4. MRI magnetic signal enhance device according to claim 1 is characterized in that the live width of the said first artificial micro-structural and the second artificial micro-structural is 0.50-1.50mm.
5. MRI magnetic signal enhance device according to claim 1 is characterized in that the distance between centers of tracks of the said first artificial micro-structural and the second artificial micro-structural is 0.05-0.15mm.
6. MRI magnetic signal enhance device according to claim 1 is characterized in that the line thickness of the said first artificial micro-structural and the second artificial micro-structural is 0.03-0.05mm.
7. MRI magnetic signal enhance device according to claim 1 is characterized in that said substrate comprises first substrate and second substrate, and first substrate and second substrate are FR-4 organic polymer substrate or ceramic substrate.
8. MRI magnetic signal enhance device according to claim 7 is characterized in that said first substrate thickness is 0.15-0.20mm.
9. MRI magnetic signal enhance device according to claim 7 is characterized in that the thickness of said second substrate is 0.05-0.10mm.
10. MRI magnetic signal enhance device according to claim 1 is characterized in that the aperture of said metallic vias is 0.50-0.90mm.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN112834969A (en) * | 2020-12-23 | 2021-05-25 | 江苏珂玛麒生物科技有限公司 | Rabbit and monkey liver water/fat separation MRI imaging method and calculation method |
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| GB2363845A (en) * | 2000-06-21 | 2002-01-09 | Marconi Caswell Ltd | Focussing RF flux |
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| CN112834969A (en) * | 2020-12-23 | 2021-05-25 | 江苏珂玛麒生物科技有限公司 | Rabbit and monkey liver water/fat separation MRI imaging method and calculation method |
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Effective date of registration: 20210518 Address after: 2 / F, software building, No.9, Gaoxin Zhongyi Road, Nanshan District, Shenzhen City, Guangdong Province Patentee after: KUANG-CHI INSTITUTE OF ADVANCED TECHNOLOGY Address before: 18B, building a, CIC international business center, 1061 Xiangmei Road, Futian District, Shenzhen, Guangdong 518034 Patentee before: KUANG-CHI INNOVATIVE TECHNOLOGY Ltd. |