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VeröffentlichungsnummerCN102784436 B
PublikationstypErteilung
AnmeldenummerCN 201110125356
Veröffentlichungsdatum29. Apr. 2015
Eingetragen16. Mai 2011
Prioritätsdatum16. Mai 2011
Auch veröffentlicht unterCN102784436A
Veröffentlichungsnummer201110125356.4, CN 102784436 B, CN 102784436B, CN 201110125356, CN-B-102784436, CN102784436 B, CN102784436B, CN201110125356, CN201110125356.4
Erfinder刘若鹏, 季春霖, 岳玉涛, 尹小明
Antragsteller深圳光启高等理工研究院, 深圳光启创新技术有限公司
Zitat exportierenBiBTeX, EndNote, RefMan
Externe Links:  SIPO, Espacenet
Microwave hyperthermia therapy radiator and microwave hyperthermia therapy device
CN 102784436 B
Zusammenfassung  übersetzt aus folgender Sprache: Chinesisch
本发明涉及微波热疗辐射器和微波热疗装置。 The present invention relates to microwave radiation and microwave hyperthermia hyperthermia devices. 微波热疗辐射器包括辐射器本体、安装在辐射器本体上的超材料面板;超材料面板包括至少一个超材料片层,超材料片层包括片状基板和设置在所述基板上的多个人造微结构,每一所述超材料片层的折射率分布均相同,超材料片层包括一个圆形区域和多个与圆形区域同心的环形区域,圆形区域和环形区域内折射率随着半径的增大连续减小且相同半径处的折射率相同,多个区域中至少存在两个相邻的第一区域及第二区域,第一区域内折射率随着半径的增大从n1连续减小到n2,第二区域内折射率随着半径的增大从n3连续减小到n4,且满足n3>n2。 Microwave hyperthermia radiation comprises radiation body, mounted on the radiator body metamaterial panel; meta-material panel comprises at least one sheet metamaterial, the metamaterial sheet comprises a sheet substrate and disposed on the substrate a plurality of persons making the micro-structure, the refractive index profile of each of the meta-material sheet are the same, the meta-material sheet comprises an annular region of a circular area and a plurality of concentric circular area, a circular area and the annular region with a refractive index continuously decreases with increasing radius and the same radius of the same refractive index, there are at least two adjacent first and second regions of the plurality of regions, the first region refractive index with increasing radius from n1 continuously decreases to n2, the refractive index of the second region is increased as the radius decreases continuously from n3 to n4, and satisfy n3> n2. 本发明使微波能量集中于病变部位,减少了正常组织的损伤,提高了热疗效率。 The present invention allows microwave energy is concentrated in the lesion, reducing the damage to normal tissue, improves the efficiency of hyperthermia.
Ansprüche(8)  übersetzt aus folgender Sprache: Chinesisch
1. 一种微波热疗辐射器,包括辐射器本体,其特征在于,还包括安装在所述辐射器本体上的超材料面板,所述超材料面板将从所述辐射器本体发出的电磁波汇聚在一汇聚区域; 所述超材料面板包括至少一个超材料片层,所述超材料片层包括片状基板和设置在所述基板上的多个人造微结构,每一所述超材料片层的折射率分布均相同,所述超材料片层包括一个圆形区域和多个与圆形区域同心的环形区域且圆心处的折射率最大;所述圆形区域和环形区域内折射率随着半径的增大连续减小且相同半径处的折射率相同,多个区域中至少存在两个相邻的第一区域及第二区域,第一区域内折射率随着半径的增大依次为%、a 2、 a3......an,且a# a 2多a 3多......多an,第二区域内折射率随着半径的增大依次为bp b2、 b3......bn,且bp b2> b 3多......多bn,且满足bpayn为不小于2的自然数,各个区域内的折射率变化满足如下关系:(af a2) < (a2_a3) <......< (an_「an) <Od1Hd2) < (b2_b3) <...... < Ov1-IU ;所述人造微结构具有相同的几何形状,每个所述区域内人造微结构的尺寸随着半径的增大连续减小且相同半径处的人造微结构的尺寸相同,多个区域中至少存在两个相邻的第一区域和第二区域,所述第一区域和第二区域内人造微结构的尺寸变化范围交集为非空。 A microwave hyperthermia radiator comprising a radiator body, characterized by further comprising mounting the radiator on a body panel of metamaterials, a metamaterial electromagnetic radiation from said body panel emitted aggregation In one aggregation region; the meta-material panel comprises at least one layer of super-material sheet, said sheet material comprises a plurality of super synthetic microstructures in sheet-like substrate and disposed on said substrate, each of said metamaterial sheet The refractive index profiles are the same, the maximum refractive index of the metamaterial film includes a circular area and a plurality of annular area and concentric with the circular area at the center; within the circular area and the annular region with a refractive index increasing radius decreases continuously and the same index of refraction at the same radius, there are at least two adjacent first and second regions of the plurality of regions, the refractive index of the first region is increased as the radius of the order of% , a 2, a3 ...... an, and a # a 2 a 3 多 多 ...... more an, the refractive index of the second region is increased as the radius of the order of bp b2, b3 .. .... bn, and bp b2> b 3 多 ...... Multi bn, and satisfy bpayn a natural number not less than 2, the refractive index variation within each region to satisfy the following relation: (af a2) <(a2_a3 ) <...... <(an_ "an) <Od1Hd2) <(b2_b3) <...... <Ov1-IU; artificial micro structure having the same geometry, each of said inner region size synthetic microstructures continuously decreases with increasing radius and the same size artificial microstructures at the same radius, there are at least two adjacent first and second regions of the plurality of regions, the first region and the size range of man-made changes in the microstructure of the second area is non-empty intersection.
2. 如权利要求1所述的微波热疗辐射器,其特征在于,所述超材料面板由多个超材料片层堆叠形成。 Microwave hyperthermia radiator according to claim 2., characterized in that the panel consists of a plurality of metamaterial metamaterial sheets stacked to form.
3. 如权利要求1或者2所述的微波热疗辐射器,其特征在于,每个所述人造微结构为由至少一根金属丝组成的平面结构或立体结构。 Microwave hyperthermia 1 or 2, wherein the radiator as claimed in claim, characterized in that each of said micro structure by artificial planar structure or three-dimensional structure composed of at least one wire.
4. 如权利要求3所述的微波热疗辐射器,其特征在于,所述金属丝为铜丝或银丝。 The microwave hyperthermia radiator according to claim 3, wherein said wire is copper or silver.
5. 如权利要求4所述的微波热疗辐射器,其特征在于,所述金属丝通过蚀刻、电镀、钻亥IJ、光刻、电子刻或离子刻的方法附着在基板上。 5. A microwave hyperthermia radiator according to claim 4, characterized in that the metal wire by etching, electroplating, drilling Hai IJ, lithography, electron or ion engraved engraved method adhered to the substrate.
6. 如权利要求1所述的微波热疗辐射器,其特征在于,所述基板由陶瓷、高分子材料、 铁电材料、铁氧材料或铁磁材料制得。 6. The microwave hyperthermia radiator according to claim 1, characterized in that said substrate is made of a ceramic, a polymer material, a ferroelectric material, ferrite materials or ferromagnetic material in the system.
7. 如权利要求1或者2所述的微波热疗辐射器,其特征在于,所述人造微结构为"工" 字形、"十"字形或"王"字形。 The microwave hyperthermia radiator 1 or 2 of the preceding claims, characterized in that said artificial microstructure as "workers" shape, "ten" shaped or "king" shape.
8. -种微波热疗装置,包括壳体,其特征在于,还包括设置于所述壳体内的微波热疗辐射器;所述微波热疗辐射器包括辐射器本体、和安装在所述辐射器本体上的超材料面板, 所述超材料面板将从所述辐射器本体发出的电磁波汇聚在一汇聚区域;所述超材料面板包括至少一个超材料片层,所述超材料片层包括片状基板和设置在所述基板上的多个人造微结构,每一所述超材料片层的折射率分布均相同,所述超材料片层包括一个圆形区域和多个与圆形区域同心的环形区域且圆心处的折射率最大,所述圆形区域和环形区域内折射率随着半径的增大连续减小且相同半径处的折射率相同,多个区域中至少存在两个相邻的第一区域及第二区域,第一区域内折射率随着半径的增大依次为%、a 2、a3……an, 且a 2多a 3多……多an,第二区域内折射率随着半径的增大依次为bp b2、b3……bn,且b1^b 2^b3^……>bn,且满足为不小于2的自然数,各个区域内的折射率变化满足如下关系:Ca^a2)彡(a2_a3)彡......彡(a n_「an)彡Od1Hd2)彡(b2_b3)彡......彡Ovfbn); 所述人造微结构具有相同的几何形状,每个所述区域内人造微结构的尺寸随着半径的增大连续减小且相同半径处的人造微结构的尺寸相同,多个区域中至少存在两个相邻的第一区域和第二区域,所述第一区域和第二区域内人造微结构的尺寸变化范围交集为非空。 8. - Species microwave hyperthermia device comprising a housing, characterized by further comprising microwave hyperthermia radiator disposed within said housing; said microwave hyperthermia radiation comprises radiation body, and mounted on the radiation metamaterial panel body on the metamaterial panel from the electromagnetic radiation emitted by body gathered in a gathering area; the metamaterial panel comprises at least one super-material sheet, the super material sheet comprises a sheet a plurality of artificial microstructures shaped substrate and provided on said substrate, each of said refractive index profile metamaterial sheet are the same, the material sheet comprises a super-circular region and a plurality of concentric circular regions The annular region and the refractive index at the center of the biggest, the circular area and the refractive index of the same refractive index as the radius increases continuously decreases and at the same radius, there are at least two more regions adjacent inner annular region The first and second regions, the first region refractive index increases as the radius of the order of%, a 2, a3 ...... an, a 2 and a 3 多 多 ...... more an, the second refractive region With the increasing rate of the radius of the order of bp b2, b3 ...... bn, and b1 ^ b 2 ^ b3 ^ ......> bn, and satisfies a natural number not less than 2, the change in refractive index within each region to satisfy the following relationship: Ca ^ a2) Pie (a2_a3) San ...... San (a n_ "an) San Od1Hd2) Pie (b2_b3) San ...... San Ovfbn); artificial micro structure having the same geometry , the size of each area of the artificial microstructure of the same size as the radius increases continuously artificial microstructures decreases and at the same radius, in the presence of a first plurality of regions of at least two adjacent second region, the first region and the second region within the size range of artificial microstructures non-empty intersection.
Beschreibung  übersetzt aus folgender Sprache: Chinesisch
微波热疗辐射器和微波热疗装置 Microwave hyperthermia and microwave hyperthermia equipment radiators

技术领域 TECHNICAL FIELD

[0001] 本发明涉及微波热疗技术,更具体地说,涉及微波热疗辐射器和微波热疗装置。 [0001] The present invention relates to a microwave thermotherapy technology, and more particularly, to microwave radiation hyperthermia and microwave hyperthermia devices.

背景技术 Background technique

[0002] 生物体受到微波的照射会产生热效应,通过高温可直接杀死肿瘤细胞。 [0002] organisms by microwave irradiation will produce thermal effects, high temperature can directly kill tumor cells. 因此,通常采用微波热疗技术治疗肿瘤。 Therefore, usually microwave hyperthermia treatment of tumors. 微波照射人体之所以产生微波生物效应,是因为人体各种组织都有固有频率,当微波频率与某组织的固有频率相同时,该组织就产生谐振吸收。 Microwave irradiation produces microwave biological effects of human reason, is because the human body has a natural frequency of a variety of organizations, when the microwave frequency and the natural frequency of an organization is the same, the organization produces a resonant absorption. 当该组织吸收的能量超过某一减阀值时,就会引起生物效应。 When the energy absorbed by the organization exceeds a certain threshold reduction would cause biological effects. 微波热疗效果好的主要原因如下: Microwave hyperthermia effect of good reasons:

[0003] (1)微波热疗是微波照射到病变部位后,病变组织吸收微波能自身产生热量,因此病变组织比其他热敷升温快,并且温度分布均匀。 [0003] (1) microwave hyperthermia microwave irradiation after the lesion, the diseased tissue absorb microwave energy self-generated heat, thus the diseased tissue warming faster than the other heat, and the temperature distribution.

[0004] (2)微波有选择加热的特性:人体的各种组织的介电常数是不相同的,因此各种组织吸收微波的能力也不相同。 [0004] (2) microwave selective heating characteristic: the dielectric constant of various tissues of the human body is not the same, so the ability to absorb various organizations microwave is not the same. 吸收微波能力强的组织升温就快,吸收能弱的升温就慢。 Ability of the organization to absorb the microwave to heat up soon, the absorbed energy is weak on the slow warming. 病变组织往往比正常组织吸收微波能力强,升温快,从而达到了选择治疗之目的。 Diseased tissue than in normal tissue often strong microwave absorption capacity, fast heating, so as to achieve the purpose of the treatment of choice. 其他热疗方法,就没有这个特性。 Other hyperthermia method, you do not have this feature.

[0005] (3)微波热疗可以确诊病变部位,而其他热敷治疗方法则不能:若病变部位是炎症,病变部位的微血管因被发炎组织的压迫而变窄,造成血液循环不畅,当用微波照射病变部位时,难免同时照射到与病变部位相毗邻的健康组织,也就是病变组织与健康组织同时被微波加热。 [0005] (3) microwave hyperthermia can be diagnosed lesions, while the other heat treatments can not: If the lesion is inflammation, microvascular lesion is inflamed tissue due to oppression and narrow, causing poor blood circulation, when used When microwave irradiation lesion, inevitably simultaneously irradiated to a lesion adjacent healthy tissue, which is the diseased tissue and healthy tissue while being heated by microwave. 对于健康组织而言,吸收微波产生的热量大部分被循环的血液带走通过皮肤散发到体外;对于病变组织,因血液循环不畅而急剧升温。 For healthy tissue, the heat circulating blood away most of the absorption of the microwave generation distributed to the body through the skin; for diseased tissue, due to poor blood circulation and rapid warming. 当局部病变组织温度升到38°C_39°C时,患部就有疼痛感了。 When the local lesions temperature rose to 38 ° C_39 ° C when there is pain of the affected area. 疼痛部位就是病变部位,从而准确确定了病变位置,这一特点对提高疗效,缩短疗程大有裨益。 Pain is part of the lesion, to accurately determine the lesion location, this feature to improve the efficacy, shorten the course of great benefit.

[0006] 热疗不仅在治疗恶性肿瘤中起重大作用,而且在治疗许多良性疾病中效果也非常显著,在临床应用中显示出了巨大的发展潜力和广阔的应用前景,使广大患者受益。 [0006] Hyperthermia not only played a major role in the treatment of malignant tumors, and in the treatment of many benign diseases effect is very significant, showing that in clinical applications huge development potential and broad prospects, the majority of patients benefit.

[0007] 但是目前的微波热疗过程中,除了照射到病变部位之外,还会照射到与病变部位相毗邻的健康组织,造成对正常组织的损伤,另外由于微波能量汇聚的程度较低,使得热疗效果也不好,加热时间较长,这是不希望看到的结果,因此,需要一种能够减少正常组织损伤、提高热疗效率的微波热疗技术。 [0007] However, the current microwave hyperthermia process, in addition to the lesion is irradiated outside, but also irradiated with the lesion adjacent healthy tissue, causing damage to normal tissue, additional microwave energy due to the low degree of aggregation, hyperthermia effect is not so good, long heating time, which is the result not want to see, therefore, need a way to reduce normal tissue damage, improve the efficiency of microwave hyperthermia hyperthermia techniques.

发明内容 SUMMARY OF THE INVENTION

[0008] 本发明要解决的技术问题在于,针对现有技术的上述微波热疗过程中损伤正常组织的缺陷,提供一种微波热疗辐射器和微波热疗装置。 [0008] The technical problem to be solved by the present invention is that, for the above-mentioned disadvantages of the prior art microwave hyperthermia during normal tissue damage, providing a microwave radiation and microwave hyperthermia hyperthermia devices.

[0009] 本发明解决其技术问题所采用的技术方案是:构造一种微波热疗辐射器,包括辐射器本体,还包括安装在所述辐射器本体上的超材料面板;所述超材料面板包括至少一个超材料片层,所述超材料片层包括片状基板和设置在所述基板上的多个人造微结构,每一所述超材料片层的折射率分布均相同,所述超材料片层包括一个圆形区域和多个与圆形区域同心的环形区域,所述圆形区域和环形区域内折射率随着半径的增大连续减小且相同半径处的折射率相同,多个区域中至少存在两个相邻的第一区域及第二区域,第一区域内折射率随着半径的增大从nl连续减小到n2,第二区域内折射率随着半径的增大从n3连续减小到n4,且满足n3 >n2。 [0009] The technical solution of the present invention is used for solving the technical problem is: to construct a microwave hyperthermia radiation, comprising radiation body, including mounted on the radiator body metamaterial panel; the metamaterial panel comprising at least one layer of super-material sheet, said sheet material comprises a plurality of super synthetic microstructures in sheet-like substrate and disposed on the substrate, the refractive index of each of said super distribution sheet material are the same, the super- sheet material comprises a circular area and a plurality of concentric annular region circular area within the circular area and the annular region refractive index increases as the radius of the same refractive index decreases continuously and at the same radius, more a region of at least two adjacent first and second regions, the first region refractive index with the radius increases continuously decreases from nl to n2, the refractive index of the second region with increasing radius decreases continuously from n3 to n4, and satisfy n3> n2.

[0010] 在本发明所述的微波热疗辐射器中,所述超材料面板由多个超材料片层堆叠形成。 [0010] In the microwave hyperthermia radiator of the present invention, the metamaterial panel by a plurality of sheets stacked to form a super-material.

[0011] 在本发明所述的微波热疗辐射器中,所述人造微结构具有相同的几何形状,每个所述区域内人造微结构的尺寸随着半径的增大连续减小且相同半径处的人造微结构的尺寸相同,多个区域中至少存在两个相邻的第一区域和第二区域,所述第一区域和第二区域内人造微结构的尺寸变化范围交集为非空。 [0011] In the microwave hyperthermia radiator according to the present invention, the synthetic micro structure having the same geometry, the size of each area of the artificial microstructure continuously decreases with the increase of the radius and the same radius Artificial same size at the micro-structure, there are at least two adjacent first and second regions of the plurality of regions, said first region and a second region within the size range of artificial microstructures non-empty intersection.

[0012] 在本发明所述的微波热疗辐射器中,每个所述人造微结构为由至少一根金属丝组成的平面结构或立体结构。 [0012] In the microwave hyperthermia radiator of the present invention, each of the micro-structure of the artificial ground plane structure or three-dimensional structure composed of at least one wire.

[0013] 在本发明所述的微波热疗辐射器中,所述金属丝为铜丝或银丝。 [0013] In the microwave hyperthermia radiator of the present invention, the metal wire is copper or silver.

[0014] 在本发明所述的微波热疗辐射器中,所述金属丝通过蚀刻、电镀、钻刻、光刻、电子刻或离子刻的方法附着在基板上。 [0014] In the microwave hyperthermia radiator of the present invention, the metal wire by etching, plating, diamond engraving, lithography, electron or ion carved engraved method adhered to the substrate.

[0015] 在本发明所述的微波热疗辐射器中,所述基板由陶瓷、高分子材料、铁电材料、铁氧材料或铁磁材料制得。 [0015] In the microwave hyperthermia radiator of the present invention, the substrate made from ceramics, polymer materials, ferroelectric materials, ferrite material or ferromagnetic material.

[0016] 在本发明所述的微波热疗辐射器中,所述人造微结构为"工"字形、"十"字形或"王"字形。 [0016] In the microwave hyperthermia radiator of the present invention, the artificial microstructure as "workers" shape, "ten" shaped or "king" shape.

[0017] 本发明还提供一种微波热疗装置,包括壳体,还包括设置于所述壳体内的微波热疗辐射器;所述微波热疗辐射器包括辐射器本体、和安装在所述辐射器本体上的超材料面板;所述超材料面板包括至少一个超材料片层,所述超材料片层包括片状基板和设置在所述基板上的多个人造微结构,每一所述超材料片层的折射率分布均相同,所述超材料片层包括一个圆形区域和多个与圆形区域同心的环形区域,所述圆形区域和环形区域内折射率随着半径的增大连续减小且相同半径处的折射率相同,多个区域中至少存在两个相邻的第一区域及第二区域,第一区域内折射率随着半径的增大从nl连续减小到n2,第二区域内折射率随着半径的增大从n3连续减小到n4,且满足n3 >n2。 [0017] The present invention also provides a microwave thermotherapy apparatus, comprising a housing, further comprising a radiator disposed in the microwave thermotherapy within said housing; said microwave hyperthermia radiation comprises radiation body, and mounted on the radiator panel body on metamaterial; said panel comprises at least one metamaterial metamaterial sheet, said sheet material comprises a plurality of super synthetic microstructures in sheet-like substrate and disposed on the substrate, each of said refractive index profile metamaterial sheet are the same, the material sheet comprises a super-circular region and a plurality of annular area concentric with the circular area, the refractive index increases as the radius of said circular area and the annular region Large radii continuously decreasing and the same index of refraction at the same, there are at least two adjacent first and second regions of the plurality of regions, the refractive index of the first region is increased as the radius decreases continuously from nl to n2, the refractive index of the second region is increased as the radius decreases continuously from n3 to n4, and satisfy n3> n2.

[0018] 在本发明所述的微波热疗装置中,所述人造微结构具有相同的几何形状,每个所述区域内人造微结构的尺寸随着半径的增大连续减小且相同半径处的人造微结构的尺寸相同,多个区域中至少存在两个相邻的第一区域和第二区域,所述第一区域和第二区域内人造微结构的尺寸变化范围交集为非空。 [0018] In a microwave hyperthermia apparatus according to the present invention, the synthetic micro structure having the same geometry, the size of each area of the artificial microstructure continuously decreases with increasing radius and the same radius the same size artificial microstructures, there are at least two adjacent first and second regions of the plurality of regions, the first region and the second region changes in the size range of synthetic microstructures non-empty intersection.

[0019] 实施本发明的技术方案,具有以下有益效果:通过在微波热疗辐射器上增加超材料面板,使得微波能量更加集中于病变部位,而与病变部位相毗邻的正常组织处的微波能量大大减少,从而缩短了热疗时间、减少了正常组织的损伤、提高了热疗效率,增强了治疗效果,也减少了患者治疗过程中的痛苦。 [0019] The technical solution of the present invention has the following beneficial effects: by increasing the metamaterials at microwave hyperthermia panel radiator so that the microwave energy is more concentrated in the lesion, and the lesion microwave energy adjacent normal tissues at greatly reduced, thereby reducing the hyperthermia time, reduce the damage to normal tissue hyperthermia improved efficiency, enhanced therapeutic effect, also reduce pain during treatment.

附图说明 Brief Description

[0020] 下面将结合附图及实施例对本发明作进一步说明,附图中: [0020] in conjunction with the accompanying drawings and the following embodiments of the present invention is further illustrated drawings in which:

[0021] 图1是依据本发明一优选实施例的微波热疗辐射器的结构示意图; [0021] FIG. 1 is a block diagram of a preferred embodiment of the present invention, microwave hyperthermia radiators example basis;

[0022] 图2是本发明所采用的超材料面板的结构示意图; [0022] FIG. 2 is a schematic diagram of the present invention employed metamaterial panels;

[0023] 图3是图2所示的超材料面板的折射率随半径变化的示意图; [0023] FIG. 3 is a schematic index metamaterial panel shown in FIG. 2 with varying radii;

[0024] 图4是图2所示的超材料面板在yz平面上的折射率分布图; [0024] FIG. 4 is shown in FIG. 2 metamaterial panel on yz plane refractive index profile;

[0025]图5是图2所示的人造微结构衍生的第二实施例的结构示意图; [0025] FIG. 5 is a schematic view of the structure of an artificial micro-structure shown in FIG. 2 derived from the second embodiment;

[0026]图6是依据本发明一优选实施例的微波热疗装置的结构示意图。 [0026] FIG. 6 is a schematic structural view of a microwave thermotherapy apparatus of the present invention based on a preferred embodiment.

具体实施方式 DETAILED DESCRIPTION

[0027]微波热疗技术对炎症、肿瘤、外伤出血、内伤淤血、体腔内疾病、慢性疾病等具有很好的治疗效果。 [0027] The microwave hyperthermia technique for inflammation, cancer, trauma, bleeding, internal injuries congestion, body cavity diseases, chronic diseases have a very good therapeutic effect. 本发明通过在微波热疗辐射器上增加超材料面板,使得微波能量更加集中于病变部位,而与病变部位相毗邻的正常组织处的微波能量大大减少,从而缩短了热疗时间、减少了正常组织的损伤、提高了热疗效率,增强了治疗效果,当然也减少了患者治疗过程中的痛苦,此发明的技术方案对了目前难以解决的肿瘤特别是恶性肿瘤(癌症)的治疗具有良好的疗效。 The present invention by increasing the microwave hyperthermia radiator metamaterial panel so that the microwave energy is more concentrated in the lesion, and the lesion microwave energy adjacent normal tissues at a greatly reduced, thereby reducing the hyperthermia time, reducing the normal damaged tissue, hyperthermia improved efficiency, enhanced therapeutic effect, of course, reduces the pain during treatment, this aspect of the present invention is difficult to solve especially malignant tumors (cancer) treatment with good effect.

[0028]超材料是一种以人造微结构2为基本单元并以特定方式进行空间排布、具有特殊电磁响应的新型材料,包括人造微结构2和供人造微结构附着的基板1。 [0028] In metamaterial is a synthetic micro-structure 2 as the basic unit in a particular manner and spatial arrangement, new materials with special electromagnetic response, including artificial synthetic microstructure 2 and attached to a substrate for the microstructure 1. 人造微结构2为由至少一根金属丝组成的平面结构或立体结构,多个人造微结构2在基板1上阵列排布,每个人造微结构2以及其所附着的基板1所占部分即为一个超材料单元。 Artificial planar structure or three-dimensional structure by at least two micro structure consisting of a wire, a plurality of synthetic microstructures in a substrate 2 arranged in an array, each synthetic micro-structure of the substrate 2, and it is attached portion that is occupied by a as a metamaterial unit. 基板1可为任何与人造微结构2不同的材料,这两种材料的叠加使每个超材料单元产生一个等效介电常数与磁导率,这两个物理参数分别对应了超材料单元的电场响应与磁场响应。 The substrate 1 may be any two different microstructures and artificial materials, the superposition of these two materials so that each metamaterial unit generates an effective permittivity and permeability, respectively, which correspond to two physical parameters of the metamaterial unit in response to an electric field and magnetic field responses. 超材料对电磁响应的特征是由人造微结构2的特征所决定,而人造微结构2的电磁响应很大程度上取决于其金属丝的图案所具有的拓扑特征和其几何尺寸。 Metamaterial electromagnetic response characteristic is determined by the characteristics of artificial microstructure 2, and 2 artificial electromagnetic response of the microstructure depends largely on the topological features of its wire has a pattern and its geometry. 根据上述原理设计超材料空间中排列的每个人造微结构2的拓扑图形和几何尺寸,就可对超材料中每一点的电磁参数进行设置。 According to the principles of design micro structure of each artificial metamaterial space arrangement and geometry topology graph 2, it can point to each metamaterial electromagnetic parameters.

[0029]图1是依据本发明一优选实施例的微波热疗辐射器100的结构示意图,该微波热疗辐射器包括辐射器本体20、安装在辐射器本体20上的超材料面板10。 [0029] FIG. 1 is a block schematic diagram 100 of microwave hyperthermia radiator according to a preferred embodiment of the present invention, which includes a microwave hyperthermia radiator radiator body 20, is mounted on the body 20 of the radiator 10 metamaterial panel. 作为公知常识我们可知,电磁波的折射率与X//成正比关系,当一束电磁波由一种介质传播到另外一种介质时,电磁波会发生折射,当物质内部的折射率分布非均匀时,电磁波就会向折射率比较大的位置偏折,通过设计超材料中每一点的电磁参数,就可对超材料的折射率分布进行调整, 进而达到改变电磁波的传播路径的目的。 As common knowledge we know, electromagnetic waves and X // proportional to the refractive index, when a bunch of electromagnetic wave propagation from one medium to another medium, the electromagnetic wave refraction occurs when the refractive index of the non-uniform distribution of the material inside, It will deflect electromagnetic waves to the refractive index of the relatively large position, through the design of metamaterials in every point of the electromagnetic parameters of the index metamaterial can adjust the distribution, thus achieve the purpose of changing the electromagnetic wave propagation path. 根据上述原理可以通过设计超材料面板10的折射率分布使从辐射器本体20发出的电磁波汇聚在一个较小的区域。 According to this principle can design a metamaterial panel 10 of the refractive index distribution so that the electromagnetic waves emitted from the radiation body 20 converge in a smaller area. 汇聚的区域的大小可依据实际的需求来设定,通过改变超材料面板10的折射率分布来设置所需的汇聚区域范围。 The size of the region of convergence can be set according to the actual demand, to set the desired range of aggregation area by changing the refractive index profile metamaterial panel 10. 在实际应用中,可根据患者病情需要,通过调整辐射器本体20的功率来改变微波热疗辐射器100的辐射强度,从而改变汇聚区域的温度,使得适合病患部位的治疗需求。 In practical applications, according to the patient's condition requires, by adjusting the power of the radiator main body 20 to change the radiation intensity microwave hyperthermia radiator 100, thereby changing the temperature of the convergence zone so that the demand for patient treatment site. 另外, 还可以通过改变超材料面板10与辐射器本体20距离来调节电磁波的汇聚区域。 In addition, you can also change the metamaterial panel 10 and the radiation from the body 20 to adjust the convergence area of electromagnetic waves.

[0030] 图1所示的超材料面板10包括至少一个超材料片层3,每个超材料片层3包括片状的基板1和附着在基板1上的多个人造微结构2,每个人造微结构2以及其所附着的基板1所占部分即为一个超材料单元。 [0030] Figure 1 shown metamaterial panel 10 includes at least one metamaterial sheet 3, a substrate 3 comprising a sheet-like material sheet layer of each super-adhered to the substrate 1 and a plurality of artificial microstructures 2, everyone making the microstructure 2 and it is attached is a part of the substrate 1 percentage metamaterial unit. 实施例中超材料面板10由多个超材料片层3堆叠形成,这各个超材料片层3之间等间距排列地组装,或两两片层之间直接前、后表面相粘合地连接成一体。 Example Super material panel 10 is formed by a plurality of sheets 3 stacked metamaterial, directly before each metamaterial between the lamellar spacing between the 3 and the like are arranged assembled, or between two sheets, after surface adhesively connected one. 具体实施时,超材料片层3的数目可依据需求来进行设计。 When the specific implementation, the number of super-material sheet layer 3 can be designed according to demand. 每个超材料片层3由多个超材料单元阵列形成,整个超材料面板10可看作是由多个超材料单元沿X、Y、Z三个方向阵列排布而成。 Each meta-material sheet 3 is formed of a plurality of metamaterial cell arrays, the entire metamaterial panel 10 can be viewed as composed of three directions along a plurality of metamaterial unit X, Y, Z arrayed together. 本发明所采用的具有电磁波汇聚功能的超材料面板10中,每个超材料单元的边长为入射电磁波波长的1/5到1/10之间。 The present invention uses electromagnetic metamaterial panel has 10 aggregation, edge length of each metamaterial unit of an incident electromagnetic wavelengths between 1/5 to 1/10. 本实施例中每个超材料片层3的折射率分布均相同,这里为了描述清楚仅对一个超材料片层3的折射率分布规律进行详细说明,其余各超材料片层3的折射率分布规律均相同。 In this embodiment each superframe material sheet layer 3 are the same refractive index profile, where the distribution of the refractive index in order to describe clearly only a metamaterial sheet 3 will be described in detail, the refractive index of the rest of the material sheet layer 3 super-distribution They are the same regularity. 通过对人造微结构2的拓扑图案、几何尺寸以及其在基板1上分布,使每个超材料片层3的折射率分布满足第一规律:超材料片层3包括一个圆形区域和多个与圆形区域同心的环形区域且圆心处的折射率最大;圆形区域和环形区域内折射率随着半径的增大连续减小且相同半径处的折射率相同;多个区域中至少存在两个相邻的第一区域及第二区域,第一区域内超材料的折射率随着半径的增大从nl 连续减小到n2,第二区域内超材料折射率随着半径的增大从n3连续减小到n4,且满足n3 >n2,即两区域相邻处存在折射率跳变。 Through artificial micro-structure topology pattern 2, geometry, and their distribution on the substrate 1, so that each slice refractive index metamaterials 3 distribution satisfies the first rule: includes a circular area metamaterial sheets 3 and a plurality circular area concentric annular region and having a refractive index at the center of the largest; the refractive index of the same refractive index as the radius increases continuously decreases and the same radius of a circular area and the annular region; a plurality of regions in the presence of at least two adjacent the first region and the second region, the refractive index of the material in the first region with the super radius increases continuously decreases from nl to n2, the refractive index of the second area with increasing radius of the meta-material from n3 decreases continuously to n4, and satisfy n3> n2, namely the existence of two regions adjacent to the refractive index jump.

[0031] 如图2所示超材料面板10由多个折射率分布规律相同的超材料片层3堆叠形成,所以本发明的超材料面板10的折射率分布满足第一规律,图3是图2所示的超材料面板10的折射率随半径变化的示意图。 [0031] 2 metamaterial panel consists of a plurality of refractive index distribution of the same meta-material sheet 3 stacked layer 10 is formed, so the index metamaterial panel of the present invention satisfies a first distribution law 10, FIG. 3 is index metamaterial panel 10 shown in Figure 2 with the change in the radius of Fig. 如图3所示超材料面板10包括3个区域,第一区域的半径长度为L1,在该区域内沿半径增加的方向每个超材料单元的折射率依次为&1、a2、 a3......an;第二区域的宽度(第二区域的半径与第一区域的半径之差)从LI变化为L2, 沿半径增大方向每个超材料单元的折射率依次为匕、b2、b3......bn;第三区域的宽度(第三区域的半径与第二区域的半径之差)从L2变化为L3,沿半径增大方向每个超材料单元的折射率依次为C1、C2、C3......cn;且各个折射率满足: 3 metamaterial panel 10 comprises three regions, a first region of a radius of the length L1, the refractive index in the region in the radial direction of increasing each metamaterial unit in the order of & 1, a2, a3 ... ... an; width (radius of the second area of difference between the radius of the first region) of the second area of change from LI to L2, the radial direction of increasing the refractive index metamaterial unit each in the order of dagger, b2, b3 ...... bn; width (radius difference between the radius of the third region of the second region) a third region changes from L2 L3, increasing the refractive index in the radial direction of each metamaterial unit in the order of C1, C2, C3 ...... cn; and each of refractive indices satisfy:

[0032] a2^:a......^an (1) [0032] a2 ^: a ...... ^ an (1)

[0033] b2^:b......^bn (2) [0033] b2 ^: b ...... ^ bn (2)

[0034] C1^ C2^C3^......cn (3) [0034] C1 ^ C2 ^ C3 ^ ...... cn (3)

[0035] 其中an,Cl>bn,n为不小于2的自然数,式(I) (2) (3)均不同时取等号。 [0035] wherein an, Cl> bn, n is a natural number of not less than 2, the formula (I) (2) (3) are not simultaneously take equal sign.

[0036] 利用超材料面板10将从辐射器本体20发出的电磁波汇聚在一个较小的区域,越靠近超材料面板10的边缘处入射电磁波和出射电磁波之间所夹的偏折角越大。 [0036] The use of electromagnetic metamaterials panel 10 from the radiation emitted by body 20 converge in a smaller area, closer to the edge of the metamaterial panel 10 of the incident electromagnetic wave and the exit deflection angle greater sandwiched between electromagnetic waves. 作为公知常识可知相邻超材料单元之间的折射率变化量越大,则电磁波的偏折角越大。 As common knowledge shows that the larger the refractive index of the amount of change in the neighboring metamaterial between units, the greater the deflection angle of the electromagnetic wave. 因此,为了实现超材料面板10边缘处的电磁波的大角度偏折以及实现平面波形式的电磁波,各个区域内超材料单元的折射率变化满足如下关系: Therefore, in order to achieve electromagnetic metamaterial panel 10 at the edge of a large deflection angle and the realization of a plane wave in the form of electromagnetic waves, the refractive index metamaterial unit within each region changes satisfy the following relation:

[0037] (a「a2) < (a2_a3) < ...... < (an_「an) < (Id1-Id2) < (b2_b3) < ...... 彡OVfbn)彡(C1-C2)彡(C2-C3)彡......彡(Clri-Cn) (4) [0037] (a "a2) <(a2_a3) <...... <(an_" an) <(Id1-Id2) <(b2_b3) <...... San OVfbn) Pie (C1-C2 ) Pie (C2-C3) San ...... Pie (Clri-Cn) (4)

[0038] 满足上述折射率变化量关系的超材料面板10,对于从辐射器本体20发出的电磁波,以折射率为%的超材料单元为圆心,随着半径的增大超材料面板10在yz平面上的折射率变化量逐渐增大,因此以ai所在的超材料单元为圆心,随着半径的增大入射的电磁波出射时偏折角度大,越靠近圆心所在的超材料单元入射的电磁波其出射偏折角越小。 [0038] satisfy the above amount of change in the relationship between the refractive index metamaterials panel 10 from the electromagnetic radiation emitted by body 20 to a refractive index of% of metamaterial unit as the center, as the radius increases metamaterial panel 10 in yz the amount of change in the refractive index in the plane is gradually increased, and therefore where ai metamaterial unit of a circle, with the radius of the incident electromagnetic wave emission increases when the deflection angle, incident closer to the center of the circle where the electromagnetic waves which metamaterial unit Angular out Shepian smaller. 通过一定的设计和计算,使得这些偏折角依次满足一定的规律,即可实现电磁波汇聚。 Through certain design and calculation, so that these deflection angle turn to meet certain rules, you can achieve the convergence of electromagnetic waves. 本发明的基于超材料的微波热疗辐射器通过设计各个超材料单元的人造微结构2,得到该单元的介电常数e和磁导率y,进而对超材料面板10的折射率分布进行设计使得各个相邻超材料单元的折射率的变化量△n能实现电磁波特定的偏折角度,即可实现球面波形式发散的电磁波转变为平面形式的电磁波。 The present invention is based on metamaterial microwave hyperthermia radiator by designing synthetic microstructures respective metamaterial unit 2, to obtain the dielectric constant e and the magnetic permeability of the element y, thereby to index metamaterial design distribution panel 10 so that each variation of the refractive index metamaterial unit adjacent the △ n to achieve a specific deflection angle of the electromagnetic wave can be realized in the form of a spherical wave diverging waves into a planar form of electromagnetic waves.

[0039] 为了更直观的表示超材料片层3在yz面上折射率折射率分布规律,将折射率相同的超材料单元连成一条线,并用线的疏密来表示折射率的大小,线越密折射率越大,则符合以上所有关系式的超材料片层3的折射率分布如图4所示。 [0039] For a more visual representation of metamaterial sheets 3 in yz plane refractive index distribution, the refractive index of the same metamaterial unit connected into a line, and with a line to indicate the size of the refractive index, density, line The more dense the refractive index is larger, the above relationship meets metamaterial sheet 3 the refractive index profile shown in Fig.

[0040] 实验证明,相同图案的人造微结构2,其几何尺寸与介电常数成e正比,因此在入射电磁波确定的情况下,通过合理设计人造微结构2的拓扑图案和不同尺寸的人造微结构2在超材料片层上的排布,就可以调整超材料面板10的折射率分布,进而实现球面波形式发散的电磁波转变为平面形式的电磁波。 [0040] Experimental results show that the microstructure of the same synthetic pattern 2, the geometric dimensions and the dielectric constant is proportional to e, so in the case of an incident electromagnetic wave is determined by the rational design of synthetic micro-micro topography in a patterning structure artificial and different sizes of 2 2 On the metamaterial structure sheet arrangement, you can adjust the refractive index profile metamaterial panel 10, so as to realize the form of a spherical wave diverging waves into a planar form of electromagnetic waves.

[0041] 实现上述折射率和折射率变化量分布关系的人造微结构2有很多种可实现方式, 对于平面结构的人造微结构2,其几何形状可以是轴对称也可以非轴对称;对于三维结构, 其可以是非90度旋转对称的任意三维图形。 [0041] The realization of the above-mentioned amount of change in refractive index and its distribution relationship artificial microstructure 2 There are many ways to achieve, for artificial microstructure planar structure 2, its geometry may be the axis of symmetry is also a non-axisymmetric can; For 3D structure, which may be non-rotational symmetry of 90 degrees at any of three-dimensional graphics.

[0042] 如图2所示平面的人造微结构2均附着在片状基材1的表面上。 [0042] Artificial microstructure shown in Figure 2 in plane 2 are attached to the surface of the sheet-like substrate 1. 图中人造微结构2呈"工"字形,包括竖直的第一金属丝201和分别连接在第一金属丝201两端且垂直于第一金属丝201的第二金属丝202。 Fig. 2 artificial microstructure were "workers" shape, the first wire includes a vertical 201 and are connected to both ends of the first wire 201 and perpendicular to the first wire of the second wire 202 201. 超材料面板10由多个相同的超材料片层3构成,每个超材料片层3的yz平面上包括一个圆形区域和多个与圆形区域同心的环形区域且圆心处的人造微结构2的尺寸最大,每个区域内"工"字形的人造微结构2的尺寸随着半径的增大连续减小,且相同半径处的人造微结构2的尺寸相同;多个区域中至少存在两个相邻的第一区域和第二区域,这两个相邻区域内人造微结构2的尺寸变化范围交集为非空,即以人造微结构2尺寸最大处为圆心,随着半径的增大至少依次存在两个相邻的第一区域和第二区域,第二区域内最大的人造微结构2的尺寸大于第一区域内最小的人造微结构2的尺寸。 3 metamaterial panel 10 formed of the same layer of a plurality of metamaterial sheets, artificial microstructures comprises a plurality of circular area and the annular region and a concentric circular area at the center of each of the three super-yz plane sheet material The maximum size of 2, man-made micro-structure within each region "workers" shape size 2 as the radius increases continuously decreases, and the man-made micro-structure of the same size at the same radius 2; there are at least two more regions adjacent the first region and a second region, the size range of artificial micro structure 2 adjacent areas within these two non-empty intersection, that is the size of the largest man-made micro structure 2 at the center, as the radius increases the presence of at least two successively adjacent first and second regions, the second largest man-made microstructure region 2 is larger than the size of the smallest in the first region 2 of synthetic microstructure dimensions.

[0043] 需要说明的是,由于实际上超材料单元是一个立方体而非一个点,因此上述圆形、 环形只是近似描述,实际上的折射率相同或基本相同的超材料单元是在一个锯齿形圆周上分布的。 [0043] It should be noted that, due to the fact metamaterial unit is a cube instead of a point, so the above circular, annular described only approximately, in fact, the same or substantially the same refractive index metamaterial unit is in a zig-zag distributed on circumference. 其具体设计类似于计算机用方形像素点绘制圆形、椭圆形等平滑曲线时进行描点的编程模式(例如OpenGL),当像素点相对于曲线很小时曲线显示为光滑,而当像素点相对于曲线较大时曲线显示有锯齿。 Be described point of its specific design is similar to a computer to draw a circle, oval, etc. a smooth curve with a square pixel programming mode (eg OpenGL), when pixels are small relative to the curve is displayed as a smooth curve, and when pixels versus large jagged curve display.

[0044]图5所示实施例是图2所示人造微结构2的衍生,图5中的衍生人造微结构2不仅包括构成"工"字形的第一金属丝201和第二金属丝202,还包括分别连接在第二金属丝202两端且垂直于第二金属丝202的第三金属丝203。 [0044] Figure 5 embodiment is derived synthetic microstructures 2 as shown in FIG. 2, FIG. 5 derived synthetic microstructure 2 includes not only constitute a "work" the first wire-shaped wire 201 and the second 202, further including a second wire 202 connected to both ends of and perpendicular to the second wire 202 of 203 third wire.

[0045] 应当理解,本发明可以采用"王"字形或"十"字形等对称结构的人造微结构2,也可采用其他非对称结构的人造微结构2,只要每个超材料片层3在yz面上的折射率分布满足上述所有关系式,通过对人造微结构2的形状、尺寸和排布进行设置即可实现电磁波汇聚到一个区域。 [0045] It should be understood that the present invention may employ an artificial micro structure "King" shaped or "ten" shaped and other symmetric structure 2, may also have other artificial microstructure asymmetric structure 2, as long as each metamaterial sheets 3 yz plane refractive index profile satisfies all of the above relation, through the micro-structure of the artificial shape, size and arrangement 2 is set to converge to a region of the electromagnetic realized.

[0046] 具体实施时,可通过计算和仿真得出其介电常数和磁导率,然后不断调整人造微结构2的形状和尺寸,直到其介电常数和磁导率的值满足上述折射率分布。 [0046] The specific implementation can be drawn from its permittivity and permeability by calculation and simulation, and then continue to adjust artificial microstructure 2 shapes and sizes until its value permittivity and permeability to satisfy the above refractive index distributed.

[0047] 上述实施例中人造微结构2由至少一根铜丝或者银丝等金属丝构成,具有特定图形。 [0047] In the above-described embodiment, the microstructure 2 is made of synthetic least one copper or silver and other metal wire, having a specific pattern. 金属线通过蚀亥U、电镀、钻亥U、光亥U、电子刻或离子刻等方法附着在基板1上。 Metal wire attached to the substrate 1 by etching Hai U, plating, drilling Hai U, light Hai U, electrons or ions engraved engraved like. 其中蚀刻是较优的制造工艺,其步骤是在设计好合适的人造微结构2的平面图案后,先将一张金属箔片整体地附着在基板1上,然后通过蚀刻设备,利用溶剂与金属的化学反应去除掉人造微结构2预设图案以外的箔片部分,余下的即可得到阵列排布的人造微结构2。 Wherein the etching is optimum manufacturing process, which step is designed microstructure suitable artificial planar pattern 2, the first piece of the metal foil is integrally attached to the substrate 1, and then by etching equipment, the use of a solvent and metal The chemical reaction to remove the foil portions artificial microstructure 2 preset pattern other than the rest of you can get an array of synthetic micro-structure arrangement 2. 基板1由陶瓷、高分子材料、铁电材料、铁氧材料或铁磁材料等制得。 Substrate 1 made from ceramic, polymer materials, ferroelectric materials, ferrite material or the like made of ferromagnetic material. 例如,聚四氟乙烯、环氧树脂、FR4、 F4b等高分子材料。 For example, polytetrafluoroethylene, epoxy, FR4, F4b other polymer materials.

[0048] 本发明还提供一种微波热疗装置600,包括壳体601、设置于壳体601内的微波热疗福射器602。 [0048] The present invention also provides a microwave hyperthermia device 600 includes a housing 601, disposed in the housing 601 of the ejector 602 Four microwave hyperthermia. 其中,微波热疗福射器602包括福射器本体6021、和安装在福射器本体6021 上的超材料面板6022。 Among them, the microwave hyperthermia blessing blessing radio transmitter 602 comprises a body 6021, and installed in 6021 on blessing ejector body metamaterial panel 6022. 其中超材料面板6022的具体结构和折射率的排布与上文的超材料面板102相同,辐射器本体6021同上文的辐射器本体20,详见图1-5及其相关描述,此处不再赘述。 Wherein like concrete structure and refractive index metamaterial panel 6022 arrangement with metamaterials panel above 102, 6021 supra radiation body radiator body 20, see Figure 1-5 and the related description, not here then repeat. 图中的结构仅为示意,并不作为对本发明的限制。 A schematic diagram of the structure only, and not as a limitation on the present invention.

[0049] 在图6中仅示出了微波热疗装置600的主要部件,为了更清楚的描述本发明的内容,其他的必要部件并未示出,例如支架等。 [0049] In Figure 6 only shows the main components of the microwave hyperthermia device 600, in order to more clearly describe the present invention, other necessary parts not shown, such as stents. 应当理解的是,只要采用本发明的技术方案得到的微波热疗设备都包含在本发明的保护范围内。 It should be understood that the present invention as long as the technical solutions obtained by microwave hyperthermia devices are included within the scope of the present invention.

[0050] 上面结合附图对本发明的实施例进行了描述,但是本发明并不局限于上述的具体实施方式,上述的具体实施方式仅仅是示意性的,而不是限制性的,本领域的普通技术人员在本发明的启示下,在不脱离本发明宗旨和权利要求所保护的范围情况下,还可做出很多形式,这些均属于本发明的保护之内。 Binding [0050] The above embodiments of the present invention, the drawings have been described, but the present invention is not limited to the above embodiment, the above-described specific embodiments are merely illustrative and not restrictive, and the field of ordinary art in light of the present invention, the present invention without departing from the purpose and scope of the claims protected by the case, but also make a lot of forms, which fall within the protection of the present invention.

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Klassifizierungen
Internationale KlassifikationA61N5/02
Juristische Ereignisse
DatumCodeEreignisBeschreibung
21. Nov. 2012C06Publication
16. Jan. 2013C10Entry into substantive examination
29. Apr. 2015C14Grant of patent or utility model