CN102784436B - Microwave hyperthermia therapy radiator and microwave hyperthermia therapy device - Google Patents
Microwave hyperthermia therapy radiator and microwave hyperthermia therapy device Download PDFInfo
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- CN102784436B CN102784436B CN201110125356.4A CN201110125356A CN102784436B CN 102784436 B CN102784436 B CN 102784436B CN 201110125356 A CN201110125356 A CN 201110125356A CN 102784436 B CN102784436 B CN 102784436B
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Abstract
The invention relates to a microwave hyperthermia therapy radiator and a microwave hyperthermia therapy device. The microwave hyperthermia therapy radiator comprises a radiator body and a meta-material panel disposed on the radiator body. The meta-material panel comprises at least a meta-material lamina which includes a sheet substrate and a plurality of artificial microstructures disposed on the substrate. Refractive index distribution of each meta-material lamina is the same. The meta-material lamina comprises a circular area and a plurality of annular areas which has a same center with the circular area. In the circular area and the annular areas, the refractive index reduces continuously with increasing radius and the refractive index is the same when the radiuses are the same. In the plurality of areas, at least two adjacent areas exist, a first area and a second area. In the first area, the refractive index continuously reduces from n1 to n2 with increasing radius, and in the second area, the refractive index continuously reduces from n3 to n4 with increasing radius, wherein n3>n2 is satisfied. The microwave hyperthermia therapy radiator and the microwave hyperthermia therapy device make microwave energy concentrate on diseased regions, thereby reducing damage of normal tissues and improving thermotherapy efficiency.
Description
Technical field
The present invention relates to microwave heat therapeutic technology, more particularly, relate to microwave radiator for thermotherapy and microwave hyperthermia device.
Background technology
The irradiation that organism is subject to microwave can produce fuel factor, directly can kill tumour cell by high temperature.Therefore, microwave heat therapeutic technology treatment tumour is usually adopted.Why microwave irradiation human body produces microwave biological effect, is to have organized intrinsic frequency because human body is various, and when microwave frequency is identical with the intrinsic frequency that certain is organized, this tissue just produces resonance absorbing.When the energy of this tissue resorption exceed a certain subtract threshold values time, will biological effect be caused.The effective main cause of microwave heat therapeutic is as follows:
(1) microwave heat therapeutic is after microwave irradiation to diseased region, and pathological tissues absorbs microwave energy self and produces heat, and therefore pathological tissues is than other hot compress quick heatings, and uniformity of temperature profile.
(2) microwave has selection to add thermal property: the dielectric constant of the various tissues of human body is not identical, and therefore the ability of various tissue resorption microwave is not identical yet.Absorbing the strong tissue of microwave ability heats up just fast, and the intensification that absorption can be weak is just slow.It is strong that pathological tissues often absorbs microwave ability than normal structure, quick heating, thus reach the object selecting treatment.Other thermotherapy methods, just do not have this characteristic.
(3) microwave heat therapeutic can make a definite diagnosis diseased region, other hot compression therapy methods then can not: if diseased region is inflammation; the capilary of diseased region narrows because of the compressing by Inflamed tissue; cause poor blood circulation; when with microwave irradiation diseased region; be irradiated to the health tissues adjoined mutually with diseased region unavoidably simultaneously, namely pathological tissues and health tissues are simultaneously by heating using microwave.For health tissues, absorb the blood that is recycled of heat major part that microwave produces take away be dispersed into by skin external; For pathological tissues, the steep temperature rise because of poor blood circulation.When local-pathological-changed tissues temperature is raised to 38 DEG C-39 DEG C, affected part just has pain.Painful area is exactly diseased region, thus accurately determines lesion locations, and this feature is to raising curative effect, and Shorten the Treatment Process is of great advantage.
Thermotherapy not only plays significant role in treatment malignant tumour, and treating effect also highly significant in many benign diseases, shows huge development potentiality and wide application prospect in clinical practice, and extensive patients is benefited.
But in current microwave heat therapeutic process, except being irradiated to diseased region, also can be irradiated to the health tissues adjoined mutually with diseased region, cause the damage of normal tissue, the degree in addition due to microwave energy convergence is lower, makes thermotherapy effect also bad, heat time is longer, this is the result not wishing to see, therefore, needs a kind of microwave heat therapeutic technology that can reduce normal tissue injury, improve thermotherapy efficiency.
Summary of the invention
The technical problem to be solved in the present invention is, for the defect of damaging normal tissue in the above-mentioned microwave heat therapeutic process of prior art, provides a kind of microwave radiator for thermotherapy and microwave hyperthermia device.
The technical solution adopted for the present invention to solve the technical problems is: construct a kind of microwave radiator for thermotherapy, comprises radiator body, also comprises the metamaterial panel be arranged on described radiator body, described metamaterial panel comprises at least one metamaterial sheet, multiple man-made microstructure that described metamaterial sheet comprises plate shape substrates and arranges on the substrate, the index distribution of metamaterial sheet described in each is all identical, described metamaterial sheet comprises a border circular areas and multiple annular region concentric with border circular areas, described border circular areas and refractive index in annular region to reduce and the refractive index at same radius place is identical continuously along with the increase of radius, two adjacent first areas and second area is at least there is in multiple region, in first area, refractive index is reduced to n2 from n1 continuously along with the increase of radius, in second area, refractive index is reduced to n4 from n3 continuously along with the increase of radius, and meet n3 > n2.
In microwave radiator for thermotherapy of the present invention, described metamaterial panel is formed by multiple metamaterial sheet is stacking.
In microwave radiator for thermotherapy of the present invention, described man-made microstructure has identical geometry, in each described region, the size of man-made microstructure reduces and the man-made microstructure at same radius place measure-alike continuously along with the increase of radius, at least there is two adjacent first areas and second area in multiple region, in described first area and second area, the change in size scope of man-made microstructure is occured simultaneously for non-NULL.
In microwave radiator for thermotherapy of the present invention, each described man-made microstructure is the planar structure or stereochemical structure that are made up of at least one one metal wire.
In microwave radiator for thermotherapy of the present invention, described wire is copper wire or filamentary silver.
In microwave radiator for thermotherapy of the present invention, described wire by etching, plating, bore quarters, photoetching, electronics carve or ion quarter method be attached on substrate.
In microwave radiator for thermotherapy of the present invention, described substrate is obtained by pottery, macromolecular material, ferroelectric material, ferrite material or ferromagnetic material.
In microwave radiator for thermotherapy of the present invention, described man-made microstructure is " work " font, " ten " font or " king " font.
The present invention also provides a kind of microwave hyperthermia device, comprises housing, also comprises the microwave radiator for thermotherapy be arranged in described housing, described microwave radiator for thermotherapy comprises radiator body and is arranged on the metamaterial panel on described radiator body, described metamaterial panel comprises at least one metamaterial sheet, multiple man-made microstructure that described metamaterial sheet comprises plate shape substrates and arranges on the substrate, the index distribution of metamaterial sheet described in each is all identical, described metamaterial sheet comprises a border circular areas and multiple annular region concentric with border circular areas, described border circular areas and refractive index in annular region to reduce and the refractive index at same radius place is identical continuously along with the increase of radius, two adjacent first areas and second area is at least there is in multiple region, in first area, refractive index is reduced to n2 from n1 continuously along with the increase of radius, in second area, refractive index is reduced to n4 from n3 continuously along with the increase of radius, and meet n3 > n2.
In microwave hyperthermia device of the present invention, described man-made microstructure has identical geometry, in each described region, the size of man-made microstructure reduces and the man-made microstructure at same radius place measure-alike continuously along with the increase of radius, at least there is two adjacent first areas and second area in multiple region, in described first area and second area, the change in size scope of man-made microstructure is occured simultaneously for non-NULL.
Implement technical scheme of the present invention, there is following beneficial effect: by increasing metamaterial panel on microwave radiator for thermotherapy, microwave energy is made more to concentrate on diseased region, and the microwave energy at the normal structure place adjoined mutually with diseased region greatly reduces, thus shorten the thermotherapy time, decrease the damage of normal structure, improve thermotherapy efficiency, enhance result for the treatment of, decrease the misery in patient treatment procedure.
Accompanying drawing explanation
Below in conjunction with drawings and Examples, the invention will be further described, in accompanying drawing:
Fig. 1 is the structural representation of the microwave radiator for thermotherapy according to one embodiment of the present invention;
Fig. 2 is the structural representation of metamaterial panel of the present invention;
Fig. 3 is the schematic diagram of refractive index with radius change of the metamaterial panel shown in Fig. 2;
Fig. 4 is the refractive index profile of the metamaterial panel shown in Fig. 2 in yz plane;
Fig. 5 is the structural representation of the second embodiment that the man-made microstructure shown in Fig. 2 derives;
Fig. 6 is the structural representation of the microwave hyperthermia device according to one embodiment of the present invention.
Detailed description of the invention
Microwave heat therapeutic technology has good result for the treatment of to disease, chronic disease etc. in inflammation, tumour, traumatism and bleeding, internal injury extravasated blood, body cavity.The present invention by increasing metamaterial panel on microwave radiator for thermotherapy, microwave energy is made more to concentrate on diseased region, and the microwave energy at the normal structure place adjoined mutually with diseased region greatly reduces, thus shorten the thermotherapy time, decrease the damage of normal structure, improve thermotherapy efficiency, enhance result for the treatment of, certainly decrease the misery in patient treatment procedure, the treatment of the right current insoluble tumour of technical scheme particularly malignant tumour (cancer) of this invention has good curative effect.
Meta Materials is a kind of is that elementary cell is also carried out spatial arrangement in a specific way, had the new material of special electromagnetic response with man-made microstructure 2, comprises man-made microstructure 2 and the substrate 1 for man-made microstructure attachment.Man-made microstructure 2 is the planar structure or stereochemical structure that are made up of at least one one metal wire, multiple man-made microstructure 2 array arrangement on substrate 1, and each man-made microstructure 2 and the shared part of the substrate accompanying by it 1 are a metamaterial unit.Substrate 1 can be any material different from man-made microstructure 2, and the superposition of this bi-material makes each metamaterial unit produce an effective dielectric constant and magnetic conductivity, the electric field response of metamaterial unit that these two physical parameters are corresponding respectively and magnetic responsiveness.The feature of Meta Materials to electromagnetic response determined by the feature of man-made microstructure 2, and the electromagnetic response of man-made microstructure 2 depends on the topological characteristic that its pattern wiry has and its physical dimension to a great extent.According to topological graph and the physical dimension of each man-made microstructure 2 arranged in above-mentioned principle design Meta Materials space, just can arrange the electromagnetic parameter of every bit in Meta Materials.
Fig. 1 is the structural representation of the microwave radiator for thermotherapy 100 according to one embodiment of the present invention, and this microwave radiator for thermotherapy comprises radiator body 20, the metamaterial panel 10 be arranged on radiator body 20.As common practise, we are known, electromagnetic refractive index with
proportional, when a branch of electromagnetic wave by a kind of Medium Propagation to another medium time, electromagnetic wave can reflect, when the index distribution of material inside is non-homogeneous, electromagnetic wave will to the larger position deviation of refractive index ratio, by the electromagnetic parameter of every bit in design Meta Materials, just can adjust the index distribution of Meta Materials, and then reach the object changing electromagnetic wave propagation path.Can by designing electromagnetic wave convergence that the index distribution of metamaterial panel 10 make to send from radiator body 20 in a less region according to above-mentioned principle.The large I in the region of converging sets according to actual demand, arranges required convergence regional extent by the index distribution changing metamaterial panel 10.In actual applications, according to conditions of patients needs, the radiation intensity of microwave radiator for thermotherapy 100 can be changed by the power of adjustment radiator body 20, thus changes the temperature converging region, make the Treatment need of applicable patient part.In addition, electromagnetic convergence region can also be regulated by changing metamaterial panel 10 with radiator body 20 distance.
Metamaterial panel 10 shown in Fig. 1 comprises at least one metamaterial sheet 3, each metamaterial sheet 3 comprises substrate 1 and attachment multiple man-made microstructure 2 on substrate 1 of sheet, and each man-made microstructure 2 and the shared part of the substrate accompanying by it 1 are a metamaterial unit.In embodiment, metamaterial panel 10 is formed by multiple metamaterial sheet 3 is stacking, equidistantly arrangement ground assembling between this each metamaterial sheet 3, or between two between lamella direct forward and backward surface link into an integrated entity bondingly.During concrete enforcement, the number of metamaterial sheet 3 can design according to demand.Each metamaterial sheet 3 is formed by multiple metamaterial unit array, and whole metamaterial panel 10 can be regarded as and formed along X, Y, Z tri-direction array arrangements by multiple metamaterial unit.Of the present invention have in the metamaterial panel 10 of electromagnetic wave convergence function, the length of side of each metamaterial unit be incident electromagnetic wave wavelength 1/5 to 1/10 between.In the present embodiment, the index distribution of each metamaterial sheet 3 is all identical, and be only described in detail to the index distribution rule of a metamaterial sheet 3 to be described clearly here, the index distribution rule of all the other each metamaterial sheet 3 is all identical.By the topological pattern to man-made microstructure 2, physical dimension and its distribute on substrate 1, make the index distribution of each metamaterial sheet 3 meet the first rule: metamaterial sheet 3 comprises a border circular areas and multiple annular region concentric with border circular areas and the refractive index of circle centre position is maximum; Border circular areas and refractive index in annular region to reduce and the refractive index at same radius place is identical continuously along with the increase of radius; Two adjacent first areas and second area is at least there is in multiple region, in first area, the refractive index of Meta Materials is reduced to n2 from n1 continuously along with the increase of radius, in second area, Meta Materials refractive index is reduced to n4 from n3 continuously along with the increase of radius, and meet n3 > n2, namely there is refractive index in two region adjacents.
Metamaterial panel 10 is formed by the metamaterial sheet 3 that multiple index distribution rule is identical is stacking as shown in Figure 2, so the index distribution of metamaterial panel 10 of the present invention meets the first rule, Fig. 3 is the schematic diagram of refractive index with radius change of the metamaterial panel 10 shown in Fig. 2.Metamaterial panel 10 comprises 3 regions as shown in Figure 3, and the radius length of first area is L1, in this region, be followed successively by a along the refractive index of each metamaterial unit in direction of radius increase
1, a
2, a
3... a
n; The width (difference of the radius of second area and the radius of first area) of second area is changed to L2 from L1, and the refractive index along each metamaterial unit of radius augment direction is followed successively by b
1, b
2, b
3... b
n; The width (difference of the radius in the 3rd region and the radius of second area) in the 3rd region is changed to L3 from L2, and the refractive index along each metamaterial unit of radius augment direction is followed successively by c
1, c
2, c
3... c
n; And each refractive index meets:
a
1≥a
2≥a
3≥……≥a
n(1)
b
1≥b
2≥b
3≥……≥b
n(2)
c
1≥c
2≥c
3≥……≥c
n(3)
Wherein b
1> a
n, c
1> b
n, n be not less than 2 natural number, get equal sign when formula (1) (2) (3) are all different.
Utilize metamaterial panel 10 by the electromagnetic wave convergence that sends from radiator body 20 in a less region, larger the closer to deflection angle folded between edge's incident electromagnetic wave and outgoing electromagnetic wave of metamaterial panel 10.Larger as the refractive index variable quantity between the known adjacent metamaterial unit of common practise, then electromagnetic deflection angle is larger.Therefore, in order to realize the electromagnetic wide-angle deviation of metamaterial panel 10 edge and realize the electromagnetic wave of plane wave form, in regional, the variations in refractive index of metamaterial unit meets following relation:
(a
1-a
2)≤(a
2-a
3)≤……≤(a
n-1-a
n)≤(b
1-b
2)≤(b
2-b
3)≤……≤(b
n-1-b
n)≤(c
1-c
2)≤(c
2-c
3)≤……≤(c
n-1-c
n)(4)
Meeting the metamaterial panel 10 of above-mentioned variations in refractive index magnitude relation, for the electromagnetic wave sent from radiator body 20, take refractive index as a
1metamaterial unit be the center of circle, along with the refractive index variable quantity of increase metamaterial panel 10 in yz plane of radius increases, gradually therefore with a
1the metamaterial unit at place is the center of circle, and during electromagnetic wave outgoing along with the increase incidence of radius, deviation angle is large, and its outgoing deflection angle of electromagnetic wave the closer to the metamaterial unit incidence at place, the center of circle is less.By certain design and calculation, make these deflection angles meet certain rule successively, can electromagnetic wave convergence be realized.Microwave radiator for thermotherapy based on Meta Materials of the present invention is by the man-made microstructure 2 of each metamaterial unit of design, obtain permittivity ε and the magnetic conductivity μ of this unit, and then make the variation delta n of the refractive index of each adjacent metamaterial unit can realize the specific deviation angle of electromagnetic wave to the index distribution design of metamaterial panel 10, the electromagnetic wave that electromagnetic wave that spherical wave form disperses changes plane form into can be realized.
In order to represent metamaterial sheet 3 refractive index refractive index regularity of distribution on yz face more intuitively, metamaterial unit identical for refractive index is connected into a line, and the size of refractive index is represented with the density of line, the closeer refractive index of line is larger, then meet the index distribution of the metamaterial sheet 3 of above all relational expressions as shown in Figure 4.
Experiment proves, the man-made microstructure 2 of identical patterns, its physical dimension becomes ε direct ratio with dielectric constant, therefore when incident electromagnetic wave is determined, by the topological pattern of appropriate design man-made microstructure 2 and the arrangement of man-made microstructure 2 in metamaterial sheet of different size, just can adjust the index distribution of metamaterial panel 10, and then realize the electromagnetic wave that electromagnetic wave that spherical wave form disperses changes plane form into.
The man-made microstructure 2 realizing above-mentioned refractive index and refractive index variable quantity distribution relation have a variety of can implementation, for the man-made microstructure 2 of planar structure, its geometry can be that axial symmetry also can non-axis symmetry; For three-dimensional structure, it can be the rotational symmetric Arbitrary 3 D figure of non-90 degree.
The man-made microstructure 2 of plane is all attached on the surface of flat substrates 1 as shown in Figure 2.In figure, man-made microstructure 2 is in " work " font, comprises the first vertical wire 201 and is connected to the first wire 201 two ends and perpendicular to the second wire 202 of the first wire 201.Metamaterial panel 10 is made up of multiple identical metamaterial sheet 3, the yz plane of each metamaterial sheet 3 comprises a border circular areas and multiple annular region concentric with border circular areas and the size of the man-made microstructure 2 of circle centre position is maximum, in each region, the size of the man-made microstructure 2 of " work " font reduces continuously along with the increase of radius, and the man-made microstructure 2 at same radius place is measure-alike; Two adjacent first areas and second area is at least there is in multiple region, in these two adjacent areas, the change in size scope of man-made microstructure 2 is occured simultaneously for non-NULL, namely with man-made microstructure 2 size maximum for the center of circle, there is two adjacent first areas and second area in the increase along with radius, the size of man-made microstructure 2 maximum in second area is greater than the size of man-made microstructure 2 minimum in first area at least successively.
It should be noted that, because in fact metamaterial unit is a cube but not a point, therefore above-mentioned circle, annular just approximate description, the metamaterial unit that actual refractive index is identical or substantially identical circumferentially distributes a zigzag.The programming mode (such as OpenGL) of described point is carried out when its specific design is similar to the smoothed curves such as computer square pixels point-rendering is circular, oval, when pixel is very little relative to curve, curve is shown as smooth, and curve shows sawtooth when pixel is larger relative to curve.
Embodiment illustrated in fig. 5 is the derivative of man-made microstructure 2 shown in Fig. 2, derivative man-made microstructure 2 in Fig. 5 not only comprises the first wire 201 and the second wire 202 of formation " work " font, also comprises being connected to the second wire 202 two ends and perpendicular to the 3rd wire 203 of the second wire 202.
Be to be understood that, the present invention can adopt the man-made microstructure 2 of the symmetrical structure such as " king " font or " ten " font, also the man-made microstructure 2 of other unsymmetric structures can be adopted, as long as the index distribution of each metamaterial sheet 3 on yz face meets above-mentioned all relational expressions, carry out setting by the shape to man-made microstructure 2, size and arrangement and can realize electromagnetic wave convergence to a region.
During concrete enforcement, draw its dielectric constant and magnetic conductivity by calculating and emulation, then constantly adjust the shape and size of man-made microstructure 2, until the value of its dielectric constant and magnetic conductivity meets above-mentioned index distribution.
In above-described embodiment, man-made microstructure 2 is made up of wires such as at least one copper wire or filamentary silvers, has special pattern.Metal wire by etching, plating, bore quarters, photoetching, electronics carve or ion quarter etc. method adhere on substrate 1.Wherein etching is preferably manufacturing process, its step is after the plane pattern designing suitable man-made microstructure 2, first a tinsel is integrally adhered on substrate 1, then etching machines is passed through, the chemical reaction of solvent and metal is utilized to get rid of foil parts beyond man-made microstructure 2 predetermined pattern, the remaining man-made microstructure 2 that can obtain array arrangement.Substrate 1 is obtained by pottery, macromolecular material, ferroelectric material, ferrite material or ferromagnetic material etc.Such as, the macromolecular material such as polytetrafluoroethylene (PTFE), epoxy resin, FR4, F4b.
The present invention also provides a kind of microwave hyperthermia device 600, comprises housing 601, the microwave radiator for thermotherapy 602 be arranged in housing 601.Wherein, microwave radiator for thermotherapy 602 comprises radiator body 6021 and is arranged on the metamaterial panel 6022 on radiator body 6021.Wherein the concrete structure of metamaterial panel 6022 is identical with metamaterial panel 102 above with the arrangement of refractive index, and radiator body 6021, with radiator body 20 above, refers to Fig. 1-5 and associated description thereof, repeats no more herein.Structure in figure is only signal, not as limitation of the present invention.
Illustrate only the critical piece of microwave hyperthermia device 600 in figure 6, in order to clearer description content of the present invention, other necessary parts is also not shown, such as support etc.Should be understood that, as long as the microwave heat therapeutic equipment adopting technical scheme of the present invention to obtain is included in protection scope of the present invention.
By reference to the accompanying drawings embodiments of the invention are described above; but the present invention is not limited to above-mentioned detailed description of the invention; above-mentioned detailed description of the invention is only schematic; instead of it is restrictive; those of ordinary skill in the art is under enlightenment of the present invention; do not departing under the ambit that present inventive concept and claim protect, also can make a lot of form, these all belong within protection of the present invention.
Claims (8)
1. a microwave radiator for thermotherapy, comprises radiator body, it is characterized in that, also comprises the metamaterial panel be arranged on described radiator body, and the electromagnetic wave convergence sent from described radiator body is converged region one by described metamaterial panel; Described metamaterial panel comprises at least one metamaterial sheet, multiple man-made microstructure that described metamaterial sheet comprises plate shape substrates and arranges on the substrate, the index distribution of metamaterial sheet described in each is all identical, and described metamaterial sheet comprises a border circular areas and multiple annular region concentric with border circular areas and the refractive index of circle centre position is maximum; Described border circular areas and refractive index in annular region to reduce and the refractive index at same radius place is identical continuously along with the increase of radius, at least there is two adjacent first areas and second area in multiple region, in first area, refractive index is followed successively by a along with the increase of radius
1, a
2, a
3a
n, and a
1>=a
2>=a
3>=...>=a
n, in second area, refractive index is followed successively by b along with the increase of radius
1, b
2, b
3b
n, and b
1>=b
2>=b
3>=...>=b
n, and meet b
1>a
n, n be not less than 2 natural number, the variations in refractive index in regional meets following relation: (a
1-a
2)≤(a
2-a
3)≤... ≤ (a
n-1-a
n)≤(b
1-b
2)≤(b
2-b
3)≤... ≤ (b
n-1-b
n); Described man-made microstructure has identical geometry, in each described region, the size of man-made microstructure reduces and the man-made microstructure at same radius place measure-alike continuously along with the increase of radius, at least there is two adjacent first areas and second area in multiple region, in described first area and second area, the change in size scope of man-made microstructure is occured simultaneously for non-NULL.
2. microwave radiator for thermotherapy as claimed in claim 1, it is characterized in that, described metamaterial panel is formed by multiple metamaterial sheet is stacking.
3. microwave radiator for thermotherapy as described in claim 1 or 2, it is characterized in that, each described man-made microstructure is the planar structure or stereochemical structure that are made up of at least one one metal wire.
4. microwave radiator for thermotherapy as claimed in claim 3, it is characterized in that, described wire is copper wire or filamentary silver.
5. microwave radiator for thermotherapy as claimed in claim 4, is characterized in that, described wire by etching, plating, bore quarters, photoetching, the method at electronics quarter or ion quarter be attached on substrate.
6. microwave radiator for thermotherapy as claimed in claim 1, it is characterized in that, described substrate is obtained by pottery, macromolecular material, ferroelectric material, ferrite material or ferromagnetic material.
7. microwave radiator for thermotherapy as described in claim 1 or 2, it is characterized in that, described man-made microstructure is " work " font, " ten " font or " king " font.
8. a microwave hyperthermia device, comprises housing, it is characterized in that, also comprises the microwave radiator for thermotherapy be arranged in described housing, described microwave radiator for thermotherapy comprises radiator body and is arranged on the metamaterial panel on described radiator body, and the electromagnetic wave convergence sent from described radiator body is converged region one by described metamaterial panel, described metamaterial panel comprises at least one metamaterial sheet, multiple man-made microstructure that described metamaterial sheet comprises plate shape substrates and arranges on the substrate, the index distribution of metamaterial sheet described in each is all identical, described metamaterial sheet comprises a border circular areas and multiple annular region concentric with border circular areas and the refractive index of circle centre position is maximum, described border circular areas and refractive index in annular region to reduce and the refractive index at same radius place is identical continuously along with the increase of radius, two adjacent first areas and second area is at least there is in multiple region, in first area, refractive index is followed successively by a along with the increase of radius
1, a
2, a
3a
n, and a
1>=a
2>=a
3>=...>=a
n, in second area, refractive index is followed successively by b along with the increase of radius
1, b
2, b
3b
n, and b
1>=b
2>=b
3>=...>=b
n, and meet b
1>a
n, n be not less than 2 natural number, the variations in refractive index in regional meets following relation: (a
1-a
2)≤(a
2-a
3)≤... ≤ (a
n-1-a
n)≤(b
1-b
2)≤(b
2-b
3)≤... ≤ (b
n-1-b
n), described man-made microstructure has identical geometry, in each described region, the size of man-made microstructure reduces and the man-made microstructure at same radius place measure-alike continuously along with the increase of radius, at least there is two adjacent first areas and second area in multiple region, in described first area and second area, the change in size scope of man-made microstructure is occured simultaneously for non-NULL.
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| CN201110125356.4A CN102784436B (en) | 2011-05-16 | 2011-05-16 | Microwave hyperthermia therapy radiator and microwave hyperthermia therapy device |
| PCT/CN2011/083068 WO2012149824A1 (en) | 2011-04-30 | 2011-11-28 | Antenna based on metamaterial, microwave thermal therapy radiator, and microwave thermal therapy device |
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| US20160166843A1 (en) * | 2014-12-11 | 2016-06-16 | Palo Alto Research Center Incorporated | Metamaterial phased array for hyperthermia therapy |
| US10307607B2 (en) | 2016-02-09 | 2019-06-04 | Palo Alto Research Center Incorporated | Focused magnetic stimulation for modulation of nerve circuits |
| US11141585B2 (en) | 2018-12-28 | 2021-10-12 | Palo Alto Research Center Incorporated | Non-invasive neural interface |
| CN112569885B (en) * | 2020-12-08 | 2021-09-17 | 四川大学 | Microwave reaction device with reflection protection |
| CN112512154B (en) * | 2020-12-08 | 2021-09-14 | 四川大学 | Device and method for improving microwave heating efficiency |
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