CN103494639B - A kind of energy targeting removes the sound Power compound Multifunctional bistoury of tumor cell - Google Patents
A kind of energy targeting removes the sound Power compound Multifunctional bistoury of tumor cell Download PDFInfo
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- CN103494639B CN103494639B CN201310434213.0A CN201310434213A CN103494639B CN 103494639 B CN103494639 B CN 103494639B CN 201310434213 A CN201310434213 A CN 201310434213A CN 103494639 B CN103494639 B CN 103494639B
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Abstract
The invention discloses a kind of sound Power compound Multifunctional bistoury of targets neoplastic cells, comprise handle, described handle is provided with cutter head and ultrasonic launching head, be provided with more than one lead channels in described handle, described ultrasonic launching head is connected with sound pump dynamograph by the wire through a described lead channels.Coventional scalpel harmony power technology combines by the present invention, synchronously tumor tissues is cleared up from both macro and micro, kill and wound more up hill and dale or kill tumor cell, farthest eliminate cancerous cell, greatly reduce the probability of cancer postoperative recurrence, improve completeness and the success rate of operation, alleviate the misery of cancer patient, there is great practical value.
Description
Technical field
The present invention relates to a kind of scalpel, particularly a kind of energy targeting removes the sound Power compound Multifunctional bistoury of tumor cell.
Background technology
The China Health statistical yearbook display of announcing for 2012, tumor is the primary cause of disease of resident's top ten causes of death reason, and crude death rate reaches 172.33/10 ten thousand, far above the heart disease be number two.2004-2005 top ten mortality of malignant tumors is followed successively by pulmonary carcinoma, hepatocarcinoma, gastric cancer, the esophageal carcinoma, colorectal cancer, leukemia, cerebroma, breast carcinoma, cancer of pancreas, osteocarcinoma, and except leukemia, other are all solid tumors, namely the observable tumor of naked eyes.Wherein, total although the resection rate of hepatocarcinoma to be improved but still less than 30%, more regrettably, even if excision, had postoperative recurrent tumor rate is also very high, and the relapse rate of 5 years can up to 70% or higher, and within 5 years, overall survival is difficult to more than 50% in recent years; Current advanced gastric carcinoma postoperative 5 years survival rates are between 40% ~ 50%; Occur in many 6 months after surgery to 2 years of the local recurrence of post operative colo-rectal cancer, colorectal cancer patients postoperative recurrence person's mean survival time (MST) is 7 months; Cerebral glioma first operation treatment after 8 ~ 9 months time, tumor easily recurs.As can be seen here, had postoperative recurrent tumor is the main cause of death.
Therefore, think at present reasonably based on the major measure that the comprehensive therapeutic plan of operation is prevention of recurrence.
It is now know that, and the recurrence of tumor and transfer and cancerous cell are not eliminated totally direct and great relation.Operation is the essential therapeutic arsenals of tumor, although postoperative chemicotherapy can kill the cancerous cell of performing the operation and cannot remove, but side effect is also very large, a lot of doctor even thinks that the very large treatment of these side effect directly results in the antineoplastic immune Disability of body and common cancerous cell has become the cancer stem cell of drug resistance, and accelerate sb.'s illness took a turn for the worse, so oppose chemicotherapy.
In sum, if have the efficiency that a kind of operating theater instruments can improve operation, the immunity do not damaged doctor again, destroy patient, and sightless for naked eyes tumor cell is just removed clean when patient's first time operation, then the probability of patient tumors recurrence will reduce greatly, significant.
No matter current scalpel is steel disc cutter, electric knife or ultrasound knife, argon-gas knife etc., the function possessed cuts and organizes, solidifies thin vessels and stop blooding.The carcinoma that operative doctor utilizes scalpel to excise is that naked eyes can be seen, but cancer cell is in sightless microscopic scale, and therefore, operative doctor cannot realize the cancer cell removing microscopic scale in operation.These cancer cell are also the bases of carcinoma recurrence, usually just in carcinoma periphery and corresponding lymph vessels tissue.
Sound dynamic therapy refers to first give sound sensitiser to tumor cell, then uses non-pyrogenic ultrasonic irradiation tumor cell, causes a series of phonochemical reaction occurs, and activates sound sensitiser molecule, by potentiation acoustodynamic effect killing tumor cell.Due to the nontoxic of sound sensitiser or low toxicity and the aggregation in tumor cell tissue thereof, in addition ultrasonic can the selectivity of focusing, penetrance and irradiated site, make sound power optionally can kill and wound the tumor cell in deep, and less to the infringement of surrounding health tissue, toxicity is also relatively less.After the directed sound power sensitizer of experimental result display injection, the white mice survival rate of employing sound power directional illumination 1 inoculated tumour is 40%, the white mice survival rate irradiating 2 inoculated tumours is 60%, the white mice survival rate irradiating 3 inoculated tumours is 70%, irradiating more than 5 times white mice survival rates is 80%, has the white mice of the inoculated tumour of part to cure completely.Mtt assay result display sound dynamic action has obvious lethal effect to various cancerous cell, and zooperal result is also consistent with it.The effect that sound power kills tumor had obtained global generally acknowledged already.But, be all that sound power is used alone all the time, make its curative effect limited; , also there is irradiated site inaccuracy, the shortcoming such as directly perceived not in alone sound dynamic therapy.
The reason that malignant tumor is difficult to treat is recurrence and the transfer of tumor cell.Namely or accepting chemicotherapy is also unable to escape misfortune most of malignant tumor patient all dies from had postoperative recurrent tumor, transfer.Malignant tumor not only brings considerable distress to patient, also consumes a large amount of health resourceses.Operation is one of essential therapeutic arsenals of malignant tumor, although operation can be done simply marvelous, " on the surface " tumor tissues has been excised completely, but also excised the lymph vessels tissue (i.e. so-called cancer radical correction) may concealing tumor cell (transfer), but still can there is recurrence and the transfer of malignant tumor in Post operation, even give chemicotherapy all invalid.
Trace it to its cause, in fact we do not remove tumor cell clean in operation process.Because patient removes is the tumor tissues that naked eyes can be seen, uses the scalpel only had about macroscopical resection organization, do not possess the effect of killing off tumor cells on microscopic scale.Therefore, once do work if we regard operation as, then its efficiency is lower, only may reach 50%, has namely excised macroscopic view part (macroscopic tumor tissues) of tumor, has not played scavenging action for the tumor cell of microcosmic part.
Operation is once the rare chance closely directly contacting tumor cell, but be limited to the function of current operating theater instruments, faced by operative doctor, tumor cell also " anopia ", helpless.Once give the tumor cell removing function of microcosmic to operating theater instruments, the radical cure effect of operation will be improved greatly, reduce the probability of carcinoma recurrence.This will open medical surgery apparatus development history new page.
Summary of the invention
Technical problem to be solved by this invention is, not enough for prior art, a kind of sound Power compound Multifunctional bistoury of targets neoplastic cells is provided, tumor tissues is synchronously carried out to the treatment on both macro and micro, synchronously realize cutting and the treatment of tumor tissues, farthest eliminate cancerous cell, greatly reduce the probability of postoperative recurrence, improve completeness and the success rate of operation.
For solving the problems of the technologies described above, the technical solution adopted in the present invention is: a kind of energy targeting removes the sound Power compound Multifunctional bistoury of tumor cell, comprise handle, described handle is provided with cutter head and ultrasonic launching head, be provided with more than one lead channels in described handle, described ultrasonic launching head is connected with sound pump dynamograph by the wire through a described lead channels.
Described cutter head can be steel disc cutter head.
Described cutter head can also be the one in electric knife head, ultrasonic cutter head, argon cutter head, water cutter head, electric gib head, is provided with two lead channels in described handle, and described cutter head is connected with cutter head driving device by the wire through another lead channels.
Operation principle of the present invention is: while operative doctor utilizes surgical knife head tumor resection tissue of the present invention, sound pump dynamograph drives ultrasonic launching head to launch sound wave, kill and wound the tumor cell in deep, thus remove tumor cell more up hill and dale, avoid cancer return.
Compared with prior art, the beneficial effect that the present invention has is: coventional scalpel harmony power technology combines by the present invention, synchronously tumor tissues is cleared up from both macro and micro, kill and wound more up hill and dale or kill tumor cell, farthest eliminate cancerous cell, greatly reduce the probability of cancer postoperative recurrence, improve completeness and the success rate of operation, alleviate the misery of cancer patient, there is great practical value.
Accompanying drawing explanation
Fig. 1 is the structural representation of an embodiment of the present invention;
Fig. 2 is the structural representation of the another kind of embodiment of the present invention.
Detailed description of the invention
As shown in Figure 1, an embodiment of the present invention comprises handle 1, handle 1 is provided with cutter head 2 and ultrasonic launching head 3, is provided with more than one lead channels in handle 1, described ultrasonic launching head 3 is connected with sound pump dynamograph 4 by the wire 6 through a described lead channels, and cutter head 2 is steel disc cutter head.
As shown in Figure 2, the cutter head 2 of the another kind of embodiment of the present invention is the one in electric knife head, ultrasonic cutter head, argon cutter head, water cutter head, electric gib head, be provided with two lead channels in described handle 1, cutter head 2 is connected with cutter head driving device 5 by the wire 7 through another lead channels.
In the present invention, sound pump dynamograph can use the directed apparats for treating tumor of DMJ-10X type series sound power.
Ultrasound wave is found can be used for activating some drugs, direct or indirect killing off tumor cells.Thisly to be gathered in tumor tissues by Ultrasound-activated and can the medicine of retention for a long time, mainly photosensitive class material (as hematoporphyrin derivative etc.) produce cooperative effect, the effect of killing tumor cell is called sonodynamic treatment.
Sound dynamic therapy system and scalpel are combined, while performing an operation, carries out sound dynamic therapy.Utilize sound dynamic therapy to patient and the radiationless damage of patient, chemical damage and the advantage with targeting, on the basis of not disturbing operation to implement, the carcinoma that scalpel cannot be removed can be organized again particularly cancer cell removing.
Utilize scalpel of the present invention, the Postoperative recurrent rate of tumor is by decline more than 50%, and Multifunctional bistoury of the present invention improves at least 50% the efficiency of operation, analyzes below in conjunction with several frequently seen tumor.
Recurrence breast cancer is not all the patient that first visit is advanced carcinoma, caused by mainly strict without the operation of tumor art in art, there is residual cancerous cell plantation through cloning propagation, in about half a year, form the large lesser tubercle of diameter 0.3 ~ 0.5cm, constantly breed, form cancer ulcer, and infiltrate costicartilage downwards, reach offside mammary gland by subcutaneous lymph chain, postoperative chemicotherapy can not avoid cancerous protuberance to recur, further illustrate in the treatment of breast carcinoma, the radical-ability of operation remains primary.So be not only must strictly grasp without tumor art rule in radical mastectomy at Radical resection, avoid causing local recurrence.In addition, when processing flap, prevent blocked up, cause cancer embolus residual in subcutaneous lymph pipe network, microvascular cancer embolus is also another major reason of recurrence.In addition, the lymph node numbers removed due to technical factor or the inconsistent axillary lymph dissection caused of operating difficulty of patient is less is also the reason of recurrence.And the Multifunctional bistoury that the problems referred to above of cancerous cell are invented by us can be solved very well: residual cancerous cell is invisible to the naked eye, but can be found by the sound wave illuminated and kill, the penetrance of sound wave itself can treat the lymphatic vessel of subcutaneous table superficial part position and microvascular cancer embolus, this penetration capacity has more advantage than the radical operation of so-called " digging to a depth of three feet " formula, because penetrating of sound wave does not need to carry out ultra-large damage operation just can carry out.And such irradiation time and irradiating machine can only just can provide in operation process, even operative doctor have employed the mode of digging to a depth of three feet, then attain a yet higher goal in conjunction with the surgical effect after this scalpel, so composite multifunction scalpel of the present invention is the inexorable trend of oncotherapy development in the future.
The position of postoperative recurrence of colorectal cancer can be divided into anastomotic stoma recurrence, intraperitoneal recurrence, nodositas recurrence, mixed type recurrence.Anastomotic stoma recurrence refers to that recurrent tumor is positioned at anastomotic stoma and contiguous intestinal tube thereof around, to intracavity or chamber outgrowth, can accompany or infiltrate without surrounding tissue; Intraperitoneal recurrence refers to the recurrent tumor on intraperitoneal placenta percreta surface, in multiple or diffusivity; Nodositas recurrence refers to the nodal-like recurrent tumor that intraperitoneal is isolated.As can be seen here, be which kind of recurrence is all relevant with the tumor cell omitted when performing the operation for the first time or the tumor cell come off, that is fail to reach " pulling the grass up by its roots ".Mixed type recurrence refers to that local and liver, lung etc. are organized and recurs simultaneously, then relevant with extruding during operation, this is the insurmountable problem of scalpel, degree can only be dropped to minimum by light and handy operation technique.The universality that sound wave irradiates and the penetration power itself had, make it just can control the transfer of cancerous cell in whole visual area, comprise the transfer that extruding etc. causes.
It is generally acknowledged, liver cancer patient recurs in early days, within usually occurring in postoperative 1 year or 2 years, causes primarily of cancerous cell (i.e. single centre origin) residual in liver.By analyzing, we list the clinically hepatocarcinoma relevant to sound dynamic therapy characteristic and excise rear common high-risk Recurrence: the edge (incisxal edge) of excision is positive, namely tumor at margins of excision remains, tumor number more (> 3), or with stellate ganglion; Trunk or Microvascular invasion in liver; Bile duct tumor thrombus; Have lymphatic metastasis, these can exhaustively illuminate characteristic by sound wave and penetration power characteristic removes clean tumor cell as much as possible.
As can be seen here, utilize composite multifunction scalpel of the present invention, doctor can closely contact usually hidden cancer cell, in the process the macroscopic view excision of sound-powered microscopic treatment and operation is combined, therefore the present invention can improve the efficiency of operation, not damage again the immunity of doctor, destruction patient, and sightless for naked eyes tumor cell is just removed clean when patient's first time operation, the probability that patient tumors is recurred greatly reduces, significant.
Claims (3)
1. the sound Power compound Multifunctional bistoury of an energy targeting removing tumor cell, comprise handle (1), it is characterized in that, described handle (1) is provided with cutter head (2) and ultrasonic launching head (3), and is provided with gap between described cutter head (2) and described ultrasonic launching head (3); Be provided with more than one lead channels in described handle (1), described ultrasonic launching head (3) is connected with sound pump dynamograph (4) by the wire through a described lead channels; While described cutter head (2) works, described sound pump dynamograph (4) drives described ultrasonic launching head (3) to launch sound wave.
2. energy targeting according to claim 1 removes the sound Power compound Multifunctional bistoury of tumor cell, and it is characterized in that, described cutter head (2) is steel disc cutter head.
3. energy targeting according to claim 1 removes the sound Power compound Multifunctional bistoury of tumor cell, it is characterized in that, described cutter head (2) is electric knife head, one in ultrasonic cutter head, argon cutter head, water cutter head, electric gib head, be provided with two lead channels in described handle (1), described cutter head (2) is connected with cutter head driving device (5) by the wire through another lead channels.
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| CN201310434213.0A CN103494639B (en) | 2013-09-23 | 2013-09-23 | A kind of energy targeting removes the sound Power compound Multifunctional bistoury of tumor cell |
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5873828A (en) * | 1994-02-18 | 1999-02-23 | Olympus Optical Co., Ltd. | Ultrasonic diagnosis and treatment system |
| US5984882A (en) * | 1996-08-19 | 1999-11-16 | Angiosonics Inc. | Methods for prevention and treatment of cancer and other proliferative diseases with ultrasonic energy |
| US6340352B1 (en) * | 1995-04-06 | 2002-01-22 | Olympus Optical Co., Ltd. | Ultrasound treatment system |
| CN101352598A (en) * | 2008-09-19 | 2009-01-28 | 于波 | All-directional ultrasonic medical system |
| CN203458468U (en) * | 2013-09-23 | 2014-03-05 | 熊力 | Sonodynamic composite multi-functional surgical knife capable of targeted removal of tumour cells |
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2013
- 2013-09-23 CN CN201310434213.0A patent/CN103494639B/en not_active Expired - Fee Related
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5873828A (en) * | 1994-02-18 | 1999-02-23 | Olympus Optical Co., Ltd. | Ultrasonic diagnosis and treatment system |
| US6340352B1 (en) * | 1995-04-06 | 2002-01-22 | Olympus Optical Co., Ltd. | Ultrasound treatment system |
| US5984882A (en) * | 1996-08-19 | 1999-11-16 | Angiosonics Inc. | Methods for prevention and treatment of cancer and other proliferative diseases with ultrasonic energy |
| CN101352598A (en) * | 2008-09-19 | 2009-01-28 | 于波 | All-directional ultrasonic medical system |
| CN203458468U (en) * | 2013-09-23 | 2014-03-05 | 熊力 | Sonodynamic composite multi-functional surgical knife capable of targeted removal of tumour cells |
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| CN103494639A (en) | 2014-01-08 |
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Granted publication date: 20150902 Termination date: 20200923 |