CN104359873A - Method for evaluating light stability of methylcyclopentadienyl manganese tricarbonyl (MMT) - Google Patents
Method for evaluating light stability of methylcyclopentadienyl manganese tricarbonyl (MMT) Download PDFInfo
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- CN104359873A CN104359873A CN201410629593.8A CN201410629593A CN104359873A CN 104359873 A CN104359873 A CN 104359873A CN 201410629593 A CN201410629593 A CN 201410629593A CN 104359873 A CN104359873 A CN 104359873A
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Abstract
The invention discloses a method for evaluating light stability of methylcyclopentadienyl manganese tricarbonyl (MMT). The method comprises the following steps: by taking light rays with the wavelength of 600+/-2nm as transmission light and distilled water as a reference sample, measuring the initial transmission ratio of an MMT sample, and recording the ratio as T1; performing exposure on the MMT sample under cold white light with the illuminance of 100Lx to 2000Lx at room temperature within 30-120 minutes, measuring the transmission ratio of the exposed MMT sample, and recording the ratio as T2; and calculating the light stability W of the MMT sample according to the following formula: W=(T2/T1)*100 percent, wherein the larger the W value is, the higher the light stability of the MMT sample is. The method disclosed by the invention has the advantages that (1) the method is easy to operate and master; (2) the equipment is simple and easily available; (3) only distilled water is used in the whole process of measuring light stability, other reagents are not used, the test cost is low, and pollution is avoided; and (4) short test time is used, and the operation can be finished within two hours.
Description
Technical field
The present invention relates to fine chemistry industry production field, is a kind of method evaluating methyl cyclopentyl-dialkyl-tricarbon manganium light stability in particular.
Background technology
Methyl cyclopentyl-dialkyl-tricarbon manganium (being called for short MMT) is a kind of unleaded gasoline octane promoter efficiently, for improvement of the octane value of gasoline, improves gasoline label.But this material is very responsive to light, when being irradiated by light (particularly bying sunlight), decomposing very soon and become black or dark-brown material.Data shows, and MMT just can almost all decompose in a few minutes in the sun, becomes refuse, and MMT decomposes and wants slowly under common light, and this is with to there is ultraviolet in sunlight relevant.Therefore, require lucifuge in the daily keeping of MMT and use procedure, and the gasoline products being added with MMT also needs to keep in Dark Place.
Seeing that in order to prevent MMT light decomposes, usually using lighttight container to hold this material and the solution containing this material.But in the use procedure of MMT, as sampled, detecting, add in the processes such as agent, often to contact light momently, complete lucifuge cannot be accomplished.If MMT product has good light stability, the impact of light on product just can be reduced.
In the preservation process of MMT, due to the instable impact of other composition in MMT product, or the oxygen in air enters in product and impacts, and MMT product exists slowly rotten possibility, and this will shorten the pot-life of MMT.In practice, we find, the MMT product of good light stability, and its anti-slowly rotten ability is good equally, the two being proportionate property.
The light stability that MMT will obtain, can take following measures: improve product purity, reduce instability component content; The solvent (solvent through hydrotreating has good stability usually) of the composite middle selection good stability of MMT product; The auxiliary agent such as light stabilizer, antioxidant is added in MMT product.
The light stability of MMT product is, is bad, there is an evaluation method and typical problem.That is, the light stability problem of MMT product how is evaluated.This is the problem to be solved in the present invention just.
Summary of the invention
Object of the present invention be just to provide a kind of operate succinct, testing expense is low, pollution-free and the method for the evaluation methyl cyclopentyl-dialkyl-tricarbon manganium light stability that test speed is fast.
Principle of the present invention is as follows: methyl cyclopentyl-dialkyl-tricarbon manganium product has two kinds of formulations usually: I type and II type.The concentration that in I type product, the concentration of MMT is not less than MMT in 97%, II type product is not less than 60%, and I type and II type product are orange-yellow under normal circumstances.We find through overtesting: under monochromatic light (sodium yellow) transmission that fresh MMT product is 600 nm at wavelength, the transmittance of reference water is close to 100%, when in product containing during impurity or when accumulating, preservation are improper and rotten, the transmittance of product will decline, by measuring the transmittance of product, MMT product quality quality can be evaluated very compactly.After irradiating a period of time under fresh MMT sample is placed in the light of certain illumination, the transmittance of MMT sample will decline to some extent, and the light stability of MMT sample is poorer, then the amplitude of transmittance decline is larger.So the transmittance after illumination divided by the initial transmission ratio before illumination, then is multiplied by 100% by us, and the numerical value obtained is defined as MMT product light stability index, and numerical value is larger, and MMT product light stability is better.
Based on above-mentioned principle, the technical scheme that the present invention proposes is: using wavelength be the light of 600 ± 2 nm as transmitted light, using distilled water as reference sample, measure the initial transmission ratio of methyl cyclopentyl-dialkyl-tricarbon manganium sample, count T1; Then the exposure-processed of certain hour is carried out under methyl cyclopentyl-dialkyl-tricarbon manganium sample being placed in the cold white light of certain illumination under room temperature, measure the transmittance of the rear methyl cyclopentyl-dialkyl-tricarbon manganium sample of exposure again, count T2, then the light stability W of methyl cyclopentyl-dialkyl-tricarbon manganium sample is gone out by following formulae discovery:
W=（T2÷T1）×100%
The value of W is larger, and methyl cyclopentyl-dialkyl-tricarbon manganium sample light stability is better.
Above-mentioned transmittance is measured by visible spectrophotometer, as the visible spectrophotometer (manufacturing plant: Shanghai INESA Analytical Instrument Co., Ltd.) of 721G type.
Above-mentioned exposure-processed is carried out in special photo-stability testing case.
Above-mentioned photo-stability testing case for meeting the illumination apparatus of the Pharmacopoeia of the People's Republic of China 2010 version annex " XIX C bulk drug and pharmaceutical preparation stability test governing principle " about strong illumination test determination, as WD-1 medicine stability test case (manufacturing plant: Tianjin Pharmacopoeia Standard Instrument Factory).
The illumination range of photo-stability testing case is adjustable, is furnished with illuminometer in chamber, can monitor illumination in case at any time, and chamber should not by the interference of natural light, and keep illumination constant.To prevent dust from entering chamber simultaneously.
Above-mentioned certain illumination refers to that illumination is 100Lx to 2000Lx, and illumination preferably is 1000Lx to 1500Lx, and optimum illumination is 1200 Lx.When illumination is lower than 100Lx, the transmittance decay of MMT is comparatively slow, and within 4 to 5 hours, just can observe significant change, the test duration is very long, so should not adopt; When illumination is greater than 2000Lx, the transmittance decay of MMT is too fast again, is not easy to test and contrast, also should not adopts.
Above-mentioned certain hour refers to 30 minutes to 120 minutes, and the time preferably is 90 minutes.
According to technique scheme, below provide concrete implementation process:
The first step, the initial transmission measuring methyl cyclopentyl-dialkyl-tricarbon manganium sample compares T1;
A) open 721G type visible spectrophotometer power switch, be set to transmittance test pattern, transmitted light wavelength is adjusted to 600 ± 2 nm, preheating 30 minutes;
B) get 3.5ml distilled water (reference sample) with transfer pipet to add in 10mm cuvette, get 3.5ml MMT sample to be measured and add in another 10mm cuvette;
C) occulter, reference sample, testing sample are put into respectively the specimen holder of spectrophotometer;
D) occulter zeroing (00.0) is inserted;
E) insert reference sample and adjust hundred (100.0);
F) built-in test sample, read test data are just the transmittance (%) of institute's test sample product;
G) repeat above-mentioned b ~ f step and do parallel experiment, the arithmetic mean getting twice parallel determinations is final measurement result, namely obtains T1.
Second step, the process of methyl cyclopentyl-dialkyl-tricarbon manganium sample exposure, and transmittance T2 after measuring its exposure;
A) WD-1 medicine stability test case power switch is opened, illumination to 1200 Lx in Adjustment Tests case, preheating 30 minutes;
B) getting testing sample 50ml adds in 100ml colourless transparent glass beaker, the beaker filling sample is put into chamber centre position, by the illumination within the scope of 30mm around illuminance transducer test beaker, requires to be 1200 Lx, otherwise beaker position should be adjusted, until meet the demands;
When measuring beaker ambient illuminance, illuminance transducer photoelectric cell is towards light source (being generally upwards), and in photoelectric cell face and beaker, the middle liquid level of sample is substantially in same level.Measure and adjust beaker ambient illuminance to complete in 1 minute.
C) timing from chamber put into by sample, exposes 90 minutes under illumination is 1200 Lx, takes out sample according to transmittance after the exposure of method working sample described in the first step, counts T2.
3rd step, calculates the light stability W of methyl cyclopentyl-dialkyl-tricarbon manganium sample.
After obtaining T1, T2, substitute into formula W=(T2 ÷ T1) × 100%, calculate the numerical value of W, just represent the light stability of this MMT sample, numerical value is larger, shows that sample light stability is better.
Advantage of the present invention has: (1) operation is succinct, is easy to grasp; (2) equipment is simple and easy to get; (3) only use distilled water in whole light stability mensuration process, do not use other reagent, testing expense is low, pollution-free; (4) measure the used time less, just can complete in 2 hours.
Accompanying drawing explanation
Fig. 1 is the graph of relation of MMT light stability and time shutter.
Embodiment
Below for the methyl cyclopentyl-dialkyl-tricarbon manganium product K T9262 of Dongchang Shandong Fine Chemical Technology Co., Ltd's production and KT9298, by testing its light stability, the present invention is further described, but be not the restriction to range of application of the present invention.
Embodiment 1 to 4: the light stability measuring KT9262.
KT9262 is above-mentioned II type MMT product, and MMT concentration is wherein 62%, and all the other components are organic solvent (based on C9 aromatic).
Implementation process see the test of above-mentioned MMT sample light stability describes, and when illumination is 1200Lx, by changing the different time shutter, measures the light stability W of KT9262.Simultaneously for ease of understanding the degree size that illumination makes KT9262 decompose, the concentration of MMT in 1 to 4 embodiment exposed sample with gas chromatograph internal mark method determination, specifically see the following form, the MMT concentration data that this method is tested in the light stability data and sample obtained as can be seen from the table is consistent, namely when MMT concentration declines, it is also on a declining curve that the present invention tests the light stability data obtained, and the light that therefore this method records stablizes the actual light stability that data can reflect MMT sample completely.
KT9262 light stability data in embodiment 1 to 4
The W of embodiment 1 to 3 is all greater than 90%, illustrates that model change is little, substantially qualified.And the W value of embodiment 4 is 88.3%, be less than 90%, and MMT concentration is lower than 60%, illustrates that Disassembling Products is too much, defective.
Embodiment 1 to 4 Plotting data broken line graph (see photo).From broken line graph, when illumination is 1200Lx, when exposing 60 minutes or 90 minutes, the light stability numerical value of MMT is more stable, can reflect the light stability quality of MMT product, also be convenient to the comparison between different MMT products.So the time shutter choosing 90 minutes is comparatively suitable.
Embodiment 5: measure light stability during KT9298 low-light (level).
KT9298 is above-mentioned I type MMT product, and MMT concentration is wherein 98%, and all the other components are methyl cyclopentadiene etc.
Implementation process see the test of above-mentioned MMT sample light stability describes, when illumination is 100Lx, the time shutter is 600 minutes, measures the initial transmission of KT9298 than T1 and light stability W, its value is respectively 97.0% and 80%, illustrates that this sample decomposes when low-light (level) slower.
Embodiment 6: measure light stability during KT9298 high illumination.
Implementation process see the test of above-mentioned MMT sample light stability describes, when illumination is 2000Lx, the time shutter is 30 minutes, measures the initial transmission of KT9298 than T1 and light stability W, its value is respectively 97.0% and 78%, illustrates that this sample decomposes when high illumination comparatively fast.
Embodiment 7: the normal light stability measuring KT9298.
Implementation process see the test of above-mentioned MMT sample light stability describes, when illumination is 1200Lx, the time shutter is 90 minutes, measures the initial transmission of KT9298 than T1 and light stability W, its value is respectively 97.0% and 92.1%, illustrates that this sample has good light stability.
Here is other companies MMT product light stability test case.
Embodiment 8: the light stability measuring Hitec3062 product.
Hitec3062 is the MMT product that Afton Chemical Corp. of the U.S. produces, and be equivalent to above-mentioned II type MMT product, wherein MMT concentration is 60%, and all the other components are mainly alkanes and aromatic solvent.
Implementation process see the test of above-mentioned MMT sample light stability describes, when illumination is 1200Lx, the time shutter is 90 minutes, measures the initial transmission of Hitec3062 than T1 and light stability W, its value is respectively 95.5% and 89.8%, the light stability of this sample is described slightly almost.
Embodiment 9: the light stability measuring MT-3062 product.
MT-3062 is the methyl cyclopentyl-dialkyl-tricarbon manganium product that Yixing skyscraping Fine Chemical Co., Ltd produces, and be equivalent to above-mentioned II type MMT product, wherein MMT concentration is 62%, and all the other components are mainly aromatic solvent.
Implementation process see the test of above-mentioned MMT sample light stability describes, be 1200Lx in illumination, when the time shutter is 90 minutes, measure the initial transmission of MT-3062 than T1 and light stability W, its value is respectively 96.5% and 85.9%, illustrates that the light stability of this sample is weaker.
The light stability of embodiment 10:Hitec3000 product.
Hitec3000 is the MMT product that Afton Chemical Corp. of the U.S. produces, and be equivalent to above-mentioned I type MMT product, wherein MMT concentration is 96%, and all the other components are mainly accessory substance in synthetic reaction and aromatic solvent.
Implementation process see the test of above-mentioned MMT sample light stability describes, when illumination is 1200Lx, the time shutter is 90 minutes, measures the initial transmission of Hitec3000 than T1 and light stability W, its value is respectively 90.6% and 84.5%, illustrates that the light stability of this sample is weaker.
Why MMT product K T9262 and KT9298 shows good light stability, is because containing the adjuvant promoting light stability in formula for a product, improve the stability of product.
The light stability of embodiment 11:KMMT98 product.
KMMT98 is the MMT product that Shandong Ke Xin petrochemical complex company limited produces, and be equivalent to above-mentioned I type MMT product, wherein MMT concentration is 98%, and all the other components are mainly accessory substance in synthetic reaction and hydrocarbons.
Implementation process see the test of above-mentioned MMT sample light stability describes, be 1200Lx in illumination, when the time shutter is 90 minutes, measure the initial transmission of KMMT98 than T1 and light stability W, its value is respectively 94.4% and 85.5%, illustrates that the light stability of this sample is weaker.
The light stability of embodiment 12:RMC3000 product.
RMC3000 is the MMT product of Amoco of the U.S., and be equivalent to above-mentioned II type MMT product, wherein MMT concentration is 62%, and all the other components are mainly alkane and aromatic solvent.
Implementation process see the test of above-mentioned MMT sample light stability describes, be 1200Lx in illumination, when the time shutter is 90 minutes, measure the initial transmission of RMC3000 than T1 and light stability W, its value is respectively 92.7% and 87.5%, illustrates that the light stability of this sample is weaker.
Claims (7)
1. evaluate the method for methyl cyclopentyl-dialkyl-tricarbon manganium light stability for one kind, it is characterized in that, using wavelength be the light of 600 ± 2 nm as transmitted light, using distilled water as reference sample, measure the initial transmission ratio of methyl cyclopentyl-dialkyl-tricarbon manganium sample, count T1; Then methyl cyclopentyl-dialkyl-tricarbon manganium sample being placed in illumination under room temperature is the exposure-processed of carrying out under the cold white light of 100Lx to 2000Lx 30 minutes to 120 minutes, measure the transmittance of the rear methyl cyclopentyl-dialkyl-tricarbon manganium sample of exposure again, count T2, then the light stability W of methyl cyclopentyl-dialkyl-tricarbon manganium sample is gone out by following formulae discovery:
W=（T2÷T1）×100%
The value of W is larger, and methyl cyclopentyl-dialkyl-tricarbon manganium sample light stability is better.
2. the method for evaluation methyl cyclopentyl-dialkyl-tricarbon manganium light stability according to claim 1, is characterized in that, described cold white light illumination is 1000Lx to 1500Lx.
3. the method for evaluation methyl cyclopentyl-dialkyl-tricarbon manganium light stability according to claim 2, is characterized in that, described cold white light illumination is 1200 Lx.
4. the method for evaluation methyl cyclopentyl-dialkyl-tricarbon manganium light stability according to claim 1, is characterized in that, the time of described exposure-processed is 90 minutes.
5. the method for evaluation methyl cyclopentyl-dialkyl-tricarbon manganium light stability according to claim 1, is characterized in that, described initial transmission ratio and the rear transmittance of exposure are all obtained by visible spectrophotometer measurement; Described exposure-processed is carried out in photo-stability testing case.
6., according to the evaluation method of the arbitrary described methyl cyclopentyl-dialkyl-tricarbon manganium light stability of claim 1-5, it is characterized in that, specifically comprise the following steps:
The first step, the initial transmission measuring methyl cyclopentyl-dialkyl-tricarbon manganium sample compares T1;
A) open 721G type visible spectrophotometer power switch, be set to transmittance test pattern, transmitted light wavelength is adjusted to 600 ± 2 nm, preheating 30 minutes;
B) get 3.5ml distilled water with transfer pipet to add in 10mm cuvette as reference sample, get 3.5ml MMT sample to be measured and add in another 10mm cuvette;
C) occulter, reference sample, testing sample are put into respectively the specimen holder of spectrophotometer;
D) occulter zeroing is inserted;
E) insert reference sample and adjust hundred;
F) built-in test sample, read test data are just the transmittance of institute's test sample product;
G) repeat above-mentioned b ~ f step and do parallel experiment, the arithmetic mean getting twice parallel determinations is final measurement result, namely obtains T1,
Second step, the process of methyl cyclopentyl-dialkyl-tricarbon manganium sample exposure, and transmittance T2 after measuring its exposure;
A) WD-1 medicine stability test case power switch is opened, illumination to 1200 Lx in Adjustment Tests case, preheating 30 minutes;
B) getting testing sample 50ml adds in 100ml colourless transparent glass beaker, the beaker filling sample is put into chamber centre position, by the illumination within the scope of 30mm around illuminance transducer test beaker, requires to be 1200 Lx, otherwise beaker position should be adjusted, until meet the demands;
C) timing from chamber put into by sample, exposes 90 minutes under illumination is 1200 Lx, takes out sample according to transmittance after the exposure of method working sample described in the first step, counts T2,
3rd step, calculates the light stability W of methyl cyclopentyl-dialkyl-tricarbon manganium sample;
After obtaining T1, T2, substitute into formula W=(T2 ÷ T1) × 100%, calculate the numerical value of W, just represent the light stability of this methyl cyclopentyl-dialkyl-tricarbon manganium sample, numerical value is larger, shows that sample light stability is better.
7. the evaluation method of methyl cyclopentyl-dialkyl-tricarbon manganium light stability according to claim 6, it is characterized in that, when the step b) of described second step tests beaker ambient illuminance, illuminance transducer photoelectric cell is towards light source, and in photoelectric cell face and beaker, the middle liquid level of sample is substantially in same level; And measure and adjust beaker ambient illuminance to complete in 1 minute.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060098927A1 (en) * | 2003-06-16 | 2006-05-11 | The Regents Of The University Of California | Integrated sensor with electrical and optical single molecule sensitivity |
| CN103398985A (en) * | 2013-07-24 | 2013-11-20 | 金能科技股份有限公司 | Method for testing quality of sorbic acid (kalium) |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060098927A1 (en) * | 2003-06-16 | 2006-05-11 | The Regents Of The University Of California | Integrated sensor with electrical and optical single molecule sensitivity |
| CN103398985A (en) * | 2013-07-24 | 2013-11-20 | 金能科技股份有限公司 | Method for testing quality of sorbic acid (kalium) |
Non-Patent Citations (4)
| Title |
|---|
| 李殿权: "离子掺杂改性云母钛反射颜料光稳定性的研究", 《中国优秀硕士学位论文全文数据库 工程科技Ⅱ辑》 * |
| 杨玲等: "红曲黄色素的稳定性及提高光稳定性方法研究", 《现代食品科技》 * |
| 欧育豹等: "含锰车甩汽油见光后诱导期及辛烷值的变化", 《石油炼制与化工》 * |
| 陈坚行等: "药物的光稳定性试验", 《中国药事》 * |
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