CN105167840A - Multi-electrode renal artery radiofrequency ablation catheter - Google Patents
Multi-electrode renal artery radiofrequency ablation catheter Download PDFInfo
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- CN105167840A CN105167840A CN201410280798.XA CN201410280798A CN105167840A CN 105167840 A CN105167840 A CN 105167840A CN 201410280798 A CN201410280798 A CN 201410280798A CN 105167840 A CN105167840 A CN 105167840A
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Abstract
A multi-electrode renal artery radiofrequency ablation catheter comprises an electrode bearing component, a transportation component, a control line and a plurality of electrodes, wherein the multiple electrodes are set to transmit adjustment energy to nerves; the electrode bearing component is set to bear the multiple electrodes; the transportation component is set to transport the electrode bearing component to positions close to the nerves; the electrodes are connected with wires; the electrode bearing component comprises a first shape and a second shape, wherein the electrode bearing component is set to be suitable for moving in blood vessels under the first shape, and the electrode bearing component is set to be suitable for transmitting the adjustment energy to the nerves via the multiple electrodes under the second shape; the remote end of the control line is connected to the remote end of the electrode bearing component; and the surface of the electrode bearing component is cut in order to make the control line control switching of the electrode bearing component between the first shape and the second shape. The multi-electrode renal artery radiofrequency ablation catheter provided by the invention is convenient in operations and simple in structure, can adjust multiple nerve point positions simultaneously, and can increase working efficiency and treatment accuracy.
Description
Technical field
The present invention relates to electrosurgery, particularly relate to a kind of multi-electrode radio frequency ablation catheter for renal artery being controlled spiral by bracing wire.
Background technology
Intractable hypertension, i.e. use 3 kinds or more medicine (all having used a diuretic) still unmanageable hypertension (sBP >=160mmHg), more common clinically, its paathogenic factor is numerous, pathogenesis is indefinite, medication effect is very poor, and Diagnosis and Treat technology is still not mature enough, one of great difficult problem becoming hypertension therapeutic.
Up-to-date animal and clinical laboratory data prove to lower intractable hypertension significantly enduringly to the adjustment (such as removing sympathetic nerve) of kidney nerve, the renal artery radiofrequency ablation art that such as latest developments go out.Renal artery radiofrequency ablation art is a kind of by electrode catheter intravascular is sent into specific part in renal artery, and release radio-frequency current causes renal artery sympathetic nerve local solidification downright bad, reaches denervated interventional techniques.Radio-frequency current damage range is little, and body can not be caused to endanger, and therefore, renal artery radiofrequency ablation art has become a kind of orthosympathetic method of effective removal renal artery.At present, occurred that single-stage radio frequency ablation catheter for renal artery is to implement renal artery radiofrequency ablation operation.The head of single-stage radio frequency ablation catheter for renal artery has single electrode, can carry out melting of One-Point Location to renal artery sympathetic nerve, and because once-through operation can only be melted a some position, therefore work efficiency is lower.
In addition, the adjustment of kidney nerve is proved to be and has certain effect to the multiple disease relevant to kidney, particularly the relevant disease that causes of renal sympathetic nerve overactivity.Such as, congestive heart failure (CHF) can cause abnormal high renal sympathetic nerve activation, thus causes the minimizing of water and the sodium removed from health, and increases the secretion of feritin.The renin secretion increased causes Renal vascular to shrink, and causes the reduction of renal blood flow.Thus kidney can make the spiral decline of heart failure condition extend for the reaction of heart failure.
Although have report in pertinent literature or patent for regulating the orthosympathetic related equipment of renal artery, current existing apparatus has the defects such as the high or inefficiency of operation inconvenience, cost of manufacture.
Given this, the invention provides a kind of multi-electrode radio frequency ablation catheter for renal artery.
Summary of the invention
Because the above-mentioned defect of prior art, technical problem to be solved of the present invention is to provide one and operates multi-electrode radio frequency ablation catheter for renal artery easily.
For achieving the above object, the invention provides a kind of multi-electrode radio frequency ablation catheter for renal artery, comprise electrode load bearing component, transfer unit and multiple electrode;
Described multiple electrode is set to adjusting energy to be delivered to nerve;
Described electrode load bearing component is set to carry described multiple electrode;
Described transfer unit is set to described electrode load bearing component is transported to the position near described nerve;
Described electrode is connected with wire;
Described electrode load bearing component has the first shape and the second shape: under described first shape, and described electrode load bearing component is set to be suitable for moving in the blood vessel; Under described second shape, described electrode load bearing component is set to be suitable for, by described multiple electrode, adjusting energy is delivered to described nerve;
It is characterized in that, also comprise control line, described control line is arranged on the inside of described electrode load bearing component and described transfer unit; The far-end of described control line is connected with the far-end of described electrode load bearing component; The surface of described electrode load bearing component is cut, and enables described control line control described electrode load bearing component and switches between described first shape and described second shape.
Further, when described control line is in releasing orientation, described electrode load bearing component is in described first shape; When described control line is in tension, described electrode load bearing component is in described second shape.
Further, the length of described electrode load bearing component is 40 ~ 140mm.
Further, described electrode load bearing component surface is according to cutting angle cutting straight line groove.
Further, multiple oval groove, multiple dumb-bell slot or multiple cylindrical groove are cut according to cutting angle in described electrode load bearing component surface.
Further, described cutting angle is between 30 ° ~ 80 °.
Further, described straight-line groove is identical at the described cutting angle on described electrode load bearing component surface.
Further, described straight-line groove is different at the described cutting angle on described electrode load bearing component surface, and described straight-line groove is greater than the described cutting angle at described electrode load bearing component near-end at the described cutting angle of described electrode load bearing component far-end.
Further, adjacent described oval groove, between described cylindrical groove and described dumb-bell slot, there is cutting interval.
Further, described cutting interval is controlled by described cutting angle.
Further, described control line adopts metal or macromolecular material to make.
Further, described metal comprises NiTi or stainless steel material.
Further, described macromolecular material comprises High molecular weight polyethylene UHMWPE, polyethylene PP, nylon Nylon or PVOH amine PGA etc.Because control line adopts metal or macromolecular material to make, so control line is more yielding at far-end, and there is good deformation-recovery ability, to protect blood vessel not damaged.
Further, the diameter of described control line is between 0.10 ~ 0.38mm.
Further, described transfer unit is the tubular structure of hollow.
Further, the material of described electrode load bearing component and described transfer unit is Ni-Ti alloy.
Further, described electrode load bearing component and described transfer unit are integral types.
Further, the diameter of described electrode load bearing component and described transfer unit is 0.5 ~ 1.0mm.
Further, outside thermoplastic one deck insulating polymer material of described electrode load bearing component and described transfer unit is as insulating barrier.
Further, described insulating polymer material PTFE, FEP, TPU or PET.
Further, described electrode is pasted on the insulating barrier of described electrode load bearing component outer surface by glue.
Further, described glue comprises UV solidification glue or epoxide-resin glue.
Further, described wire bonds at the inner surface of described electrode, and is positioned at outside the described insulating barrier of described electrode load bearing component.
Further, pyrocondensation one deck heat-shrink tube on described insulating barrier and described wire.
Further, the position that described heat-shrink tube is answered at described electrode pair is provided with opening, and described wire is entered in described heat-shrink tube by described opening.
Further, described first shape of described electrode load bearing component is straight or approximate straight; Described second shape of described electrode load bearing component is spiral type or approximate spiral.
Further, the spiral diameter of described second shape is 4-12mm.
Further, the number of described electrode is 2-6.
Further, when described electrode load bearing component is in described second shape, adjacent described electrode is 4-15mm in vessel axis spacing upwards.
Further, described blood vessel behaviour renal artery.
Further, the cross section of described electrode is annular, is sheathed on described electrode load bearing component.
Further, described pipe guide also comprises guard block, and the near-end of described guard block is connected to the far-end of described electrode load bearing component.
Further, described guard block is soft head or spring, to reduce the injury of ablation catheter to blood vessel.
Further, the material of described spring is Ni-Ti alloy or rustless steel.
Further, the length of described spring is 5 ~ 30mm; Spiral external diameter is 0.25-0.6mm; The wire diameter of described spring is 0.045-0.12mm.
Further, the material of described soft head is silica gel, thermoplastic elastic body.
Further, described pipe guide also comprises Control Component, and described Control Component comprises the handle gripped for user.
Further, described transfer unit, described control line and described wire are installed in described handle.
Further, the connection cord of described handle and external energy generator is set to one, or described handle and described external energy generator are interconnected by conversion port.
Further, the energy that described external energy generator occurs is one or more in radio-frequency (RF) energy, heat energy, electromagnetic energy, ultrasonic energy, microwave energy and luminous energy.
Further, described handle controls described first shape of described electrode load bearing component and described second shape by described control line:
When described control line strained by described handle, described electrode load bearing component is in described second shape;
When described in described handle lock during control line, described electrode load bearing component is in described first shape.
Further, the multiple described electrode of described Control Component control works simultaneously.
Further, described Control Component controls motor described in each and works independently.
Further, described nerve is for being positioned at the renal sympathetic nerve on people's renal artery, and described " position near described nerve " refers to and be positioned at described renal artery.
Further, described adjustment refer to by damage or non-invasive mode remove or reduce the activation of described nerve.
Further, when described electrode load bearing component moves in the blood vessel, described electrode load bearing component not injured blood vessel wall.
Further, the full-size of described electrode load bearing component in the radial direction of described blood vessel is not more than the internal diameter of described blood vessel.
Further, the full-size of described electrode load bearing component in the radial direction of described blood vessel is not more than 3mm.
Further, described " moving in the blood vessel " also comprises the bending section by blood vessel.
Further, described electrode load bearing component is used for position adjusting energy being delivered to described nerve, refer to when described electrode load bearing component in the blood vessel time, at least one electrode is in the position of contact blood vessel wall.
Further, the full-size of described electrode load bearing component in the radial direction of described blood vessel is 4-12mm, and at least one electrode is in full-size place.
Multi-electrode radio frequency ablation catheter for renal artery provided by the invention, by cutting electrode load bearing component surface, the shape that use is simple, cost is lower, control line that is convenient operation carrys out control electrode load bearing component, thus realize multi-electrode radio frequency ablation catheter for renal artery at endovascular movement or transmission adjusting energy.Adopt multi-electrode radio frequency ablation catheter for renal artery disclosed by the invention, operate easier, greatly reduce the workload of medical worker, also for the valuable time has been striven in operation, greatly increase the chance of success of operation, there is very strong Clinical practicability.
Multi-electrode radio frequency ablation catheter for renal artery provided by the invention, multiple electrode both can separate control separately, can control again to multiple electrode simultaneously.When separately controlling, the duty of any one electrode is not by the impact of other electrodes, and medical worker according to actual needs, can select one, part or all of electrode release regulation energy.When controlling at the same time, can regulate multiple neural site simultaneously or selective control be carried out to some neural site, thus increase work efficiency, and improve the accuracy for the treatment of further, and when some electrode failure, medical worker can select working electrode flexibly, greatly have submitted the disposal ability of equipment chance failure, ensure normally carrying out of operation, there is important clinical meaning.
Be described further below with reference to the technique effect of accompanying drawing to design of the present invention, concrete structure and generation, to understand object of the present invention, characteristic sum effect fully.
Accompanying drawing explanation
Fig. 1 is the structural representation of people's kidney and linked groups;
Fig. 2 is the arteriorenal structural representation of people;
Fig. 3 is the ingredient schematic diagram of a kind of detailed description of the invention of multi-electrode radio frequency ablation catheter for renal artery provided by the invention, and this diagram is the first shape of electrode load bearing component;
Fig. 4 is the schematic diagram of the another kind of state of the multi-electrode radio frequency ablation catheter for renal artery shown in Fig. 3, and this diagram is the second shape of electrode load bearing component;
Fig. 5 is the profile of the first shape of the electrode load bearing component of the multi-electrode radio frequency ablation catheter for renal artery shown in Fig. 3;
Fig. 6 is the surperficial schematic diagram being cut into a preferred embodiment of straight-line groove of electrode load bearing component of multi-electrode radio frequency ablation catheter for renal artery provided by the invention, and this diagram is the first shape of electrode load bearing component;
Fig. 7 is the surperficial schematic diagram being cut into another preferred embodiment of straight-line groove of electrode load bearing component of multi-electrode radio frequency ablation catheter for renal artery provided by the invention, and this diagram is the first shape of electrode load bearing component;
Fig. 8 is the surperficial schematic diagram being cut into a preferred embodiment of dumb-bell slot of electrode load bearing component of multi-electrode radio frequency ablation catheter for renal artery provided by the invention, and this diagram is the first shape of electrode load bearing component;
Fig. 9 is the surperficial schematic diagram being cut into another preferred embodiment of dumb-bell slot of electrode load bearing component of multi-electrode radio frequency ablation catheter for renal artery provided by the invention, and this diagram is the first shape of electrode load bearing component;
Figure 10 is the surperficial schematic diagram being cut into a preferred embodiment of cylindrical groove of electrode load bearing component of multi-electrode radio frequency ablation catheter for renal artery provided by the invention, and this diagram is the first shape of electrode load bearing component;
Figure 11 is the surperficial schematic diagram being cut into a preferred embodiment of elliptical slot of electrode load bearing component of multi-electrode radio frequency ablation catheter for renal artery provided by the invention, and this diagram is the first shape of electrode load bearing component;
Figure 12 is the surperficial schematic diagram being cut into another preferred embodiment of elliptical slot of electrode load bearing component of multi-electrode radio frequency ablation catheter for renal artery provided by the invention, and this diagram is the first shape of electrode load bearing component;
In the present invention, the abbreviation of using:
PTFE refers to politef, i.e. Polytetrafluoroethene;
FEP refers to fluorinated ethylene propylene copolymer, i.e. Fluorinatedethylenepropylene;
TPU refers to Polyurethane Thermoplastic Elastomer rubber, i.e. Thermoplasticpolyurethanes;
PET refers to polyethylene terephthalate, i.e. Polyethyleneterephthalate.
Detailed description of the invention
Below in conjunction with the drawings and specific embodiments, the present invention will be further described.For convenience of explanation, by the close user (or handle) of device or parts or away from needing the one end in the neural site regulated to be called " near-end " in the present invention, by device or parts away from user (or handle) or near needing the one end in the neural site regulated to be called " far-end ".
In the present invention adjustment nerve refer to by damage or non-invasive mode remove or reduce the activation of described nerve.Fig. 1-Fig. 4 shows provided by the present invention for regulating neural device and the preferred detailed description of the invention of one of using method thereof.This detailed description of the invention is example for the device of mediator's kidney nerve.
Fig. 1-Fig. 2 shows linked groups and the structure of people's kidney.As shown in Figure 1, Ren Shen linked groups comprises kidney K11 anatomically, and kidney K11 is supplied to oxygen containing blood by renal artery RA12.Renal artery RA12 is connected to heart via the aortic artery AA of abdominal part.The blood of deoxidation flows to heart via renal veins RV13 and postcava IVC14 from kidney.Fig. 2 is the anatomical part of diagram kidney in more detail.More specifically, kidney anatomy also comprises the neural RN21 of kidney along the axial L longitudinal extension of renal artery RA12.The neural RN21 of kidney is generally in the adventitia of described tremulous pulse.In this specific embodiment, the device provided is positioned at the neural RN21 of kidney on renal artery RA12 for regulating, and described adjustment refers to the activation being removed or reduce the neural RN21 of kidney by damage or non-invasive mode.As the change of this detailed description of the invention, if need to regulate the nerve at other position (such as, heart related neural), or need other regulative mode (such as, need further to improve neural activation), those skilled in the art can according to the present invention make can rational expectation, the adjustment that do not need to be put to creative work.
Of the present invention for regulating neural wire installation concrete as shown in Figure 3, comprise and be delivered at least two electrodes 101 of described nerve and the electrode load bearing component 102 for carrying electrode 101 for adjusting energy.
When electrode is in time needing the neural site regulated, electrode discharges certain energy in this neural site, thus plays the effect regulating this neural site (such as, reduce or eliminate orthosympathetic activation):
1. electrode realizes this object by heat being delivered to this neural site.Such as, heat transfer heating mechanism for neuroregulation can comprise heating ablation and the non-thermal change that melts or damage, such as, the temperature of target nerve fiber can be increased to over required threshold value to realize the non-thermal change melted, or exceed higher temperature to realize the thermal change melted.Such as, target temperature can about 37 DEG C-45 DEG C (the thermal change temperature for non-thermal ablation), or described target temperature can at about 45 DEG C or higher, for the thermal change melted;
2. electrode realizes this object by cooling being delivered to this neural site.Such as, the temperature of target nerve fiber is reduced to less than about 20 DEG C to realize the thermal change of non-frozen, or the temperature of target nerve fiber is reduced to less than about 0 DEG C to realize freezing thermal change;
3. electrode realizes this object by energy field being applied to target nerve fiber.This energy field can comprise: electromagnetic energy, radio frequency, ultrasound wave (comprising high-intensity focusing ultrasonic wave), microwave, luminous energy (comprising laser, infrared ray and near infrared ray) etc.Such as, thermoinducible neuroregulation can by by pulse or continuous print heat energy field be delivered to target nerve fiber and realize.Wherein, a kind of ratio more preferably energy mode be the pulse heat energy of pulse radiation frequency electric field or other type.The pulse heat energy of pulse radiation frequency electric field or other type can facilitate larger heat level, longer total duration and/or better controlled intravascular renal neuroregulation to treat.
Which kind of no matter by energy mode realize regulating neural object, when user uses device provided by the present invention to carry out work, electrode needs to be electrically connected with this energy of generation (such as radiofrequency generator) or the equipment that makes electrode itself produce this energy.The prior art that the connection of these equipment and electrode and these equipment is well known to those skilled in the art (such as, interface for connecting these equipment is set in apparatus of the present invention, can plug and play be realized during use), no longer describe in detail here.
In the specific embodiment of the present invention, the mode of electrode 101 near the neural site of the kidney needing to regulate is: pipe guide enters human body via blood vessel, by renal artery inwall near neural site.Therefore, when using the device that provides of this detailed description of the invention to carry out work, electrode should be realized and can be close to blood vessel thus the nerve of effect relevant position, needing again electrode can move easily in the blood vessel, and not injured blood vessel wall.This detailed description of the invention adopts following technical scheme to solve this technical problem: electrode load bearing component 102 of the present invention has the first shape (as shown in Figure 4) and the second shape (as shown in Figure 3).As shown in Figure 4, the first shape is straight or close to straight straight shape (or elongate is fibrous or thread), the cross section of this bar shaped is preferably circular or sub-circular, and the widest part of cross section is less than the interior diameter of blood vessel.Like this, under the first shape, when electrode load bearing component 102 moves in the blood vessel, electrode load bearing component 102 can not injured blood vessel wall.When needing to regulate the nerve on renal artery, because the arteriorenal interior diameter of people is generally 4-7mm, therefore, the full-size of electrode load bearing component 102 in arteriorenal radial direction is not more than 4mm, preferably be set to 1-2mm, both can meet at Ink vessel transfusing convenient mobile, and there is again enough rigidity and be convenient to make, and the size of the wound of patient can be reduced.As the change of this detailed description of the invention, the first shape also can allow certain bending or corrugated bending, and its cross section also can be other shape, as long as its smooth surface, can move and not injured blood vessel wall at Ink vessel transfusing easily.
Under the second shape of electrode load bearing component 102, electrode 101 is in the position being applicable to adjusting energy being delivered to kidney nerve.As shown in Figure 3, in this specific embodiment, the second shape entirety of electrode load bearing component 101 is spiral type.When electrode load bearing component 102 entirety is spiral type, in the radial direction of blood vessel (axis perpendicular to blood vessel), the widest part of electrode load bearing component 102 is larger than the first shape, and the electrode 101 that so just can make it to carry comes close to or in contact with blood vessel wall, thus neural near kidney.Through groping, consider that blood vessel has certain elasticity, it is more suitable that the diameter of spiral is set to 4-8mm.Such as, for the individuality (such as internal diameter is about 4mm) that renal artery internal diameter is less, the diameter of spiral can be set to about 5mm; For the individuality (such as internal diameter is about 7mm) that renal artery internal diameter is larger, the diameter of spiral can be set to about 8mm.As the change of this detailed description of the invention, the second shape also can be other shape, such as, has round and smooth bending irregular shape, as long as when described electrode load bearing component in the blood vessel time, electrode is in the position contacting blood vessel wall.
Pipe guide in this detailed description of the invention also comprises the transfer unit 103 for electrode load bearing component 102 being transported to the position (being namely transported in renal artery) near kidney nerve.The shape of transfer unit 103 is bar shaped (or elongate is fibrous or thread), and have the rigidity and flexible that are applicable to movement in the blood vessel, its length can be arranged as required.Such as, if user needs by being transported in renal artery through femoral artery place by adjusting part 100, the length of transfer unit 103 can be configured 80cm to 130cm (about 105cm is the most suitable); If user needs to be transported in renal artery by trans-radial place by electrode load bearing component 102, the length of transfer unit 103 can be configured 130cm to 160cm (about 155cm is the most suitable).The cross section of transfer unit 103 is preferably circular, hollow tubular.
Wherein, transfer unit 103 and electrode load bearing component 102 are integral types, and electrode load bearing component 102 and transfer unit 103 are preferably Ni-Ti pipe.
Electrode load bearing component 102 and transfer unit 103 are integral types, specifically as shown in Figure 5, outer surface thermoplastic one deck insulating polymer material of electrode load bearing component 102 and transfer unit 103 is as insulating barrier 105, and wherein, insulating polymer material is PTFE, FEP, TPU or PET.And the surface of insulating barrier 105 is socketed electrode 101 on electrode load bearing component 102, and wire 301 is welded on the inner surface of electrode 101; Last pyrocondensation one deck heat-shrink tube 107 on the surface of wire 301 and insulating barrier 105 again.Wherein, heat-shrink tube 107 has opening (specifically not marking in the drawings) in the position corresponding with electrode 101, and wire 301 is entered in heat-shrink tube 107 by this opening.
In this specific embodiment, electrode 101 is annular, and is socketed in the outer surface of insulating barrier 105.Like this, when electrode load bearing component 102 is spiral type (in renal artery), the electrode 101 on electrode load bearing component 102 is in the position (neural near kidney) of contact renal artery inwall, so just can carry out adjustment work.In order to make electrode 101 firmly be arranged on the insulating barrier 105 of electrode load bearing component 102, and reducing the damage to blood vessel wall as far as possible, glue can be used to be bonded on insulating barrier 105 by electrode 101, and formed and seamlessly transit 106 between electrode 101 and insulating barrier 105.This kind of glue can select UV to solidify glue, epoxide-resin glue or its mixture, has both had the biocompatibility that can reach medical application, and has had certain cohesive force again to metal alloy and macromolecular material.In addition, the wire 301 being connected to energy generation apparatus (such as radiofrequency generator) is welded on the inner surface of electrode 101, then at surperficial reheating contracting one deck heat-shrink tube 107 of wire 301 and insulating barrier 105.Such set-up mode can make wire 301 be connected to energy generation apparatus simply and easily, and whole pipe guide insulate to use heat-shrink tube namely to ensure that, is closely fixed on electrode load bearing component 102 and transfer unit 103 by conduit 301 again.When having multiple electrode, need to arrange many respectively by the wire 301 of multiple Electrode connection to energy generation apparatus.Electrode load bearing component 102 can also be arranged the element (such as, thermocouple) for measuring tempeature and corresponding wire 301, the routine being arranged as this area of wire 301 and thermocouple is arranged, and no longer describes in detail here.
In this specific embodiment, the number of electrode 101 is four.When electrode load bearing component 102 is in the second shape, namely during helical form, adjacent electrode is that 4-15mm is more suitable at the distance D axially of blood vessel.In general, when carrying out the operation of kidney nerve ablation, 3-8 site of kidney nerve is melted.Therefore, when utilizing the device in this detailed description of the invention to carry out work, the location (making electrode contact blood vessel) of Primary regulation assembly can complete melting of four sites, and completes whole ablative surgery and only need the positioning instant carrying out twice adjusting part can.As the change of this detailed description of the invention, the number of electrode also can be set to 2-6, if but number is more, the cost of manufacture of whole device can be increased; If number is less, the work efficiency of ablative surgery can be reduced.The metal or metal alloy that the material of electrode can adopt biocompatibility better or more stable, such as platinum group metal (as platinumiridio).
In this specific embodiment, guard block 105 is also provided with at the far-end of electrode load bearing component 102.An effect of guard block 105 reduces or avoids vascular damaged, when touching blood vessel wall, because self is enough soft and can resilience rapidly, can not cause damage to blood vessel; Another effect of guard block 105 plays guide effect to whole pipe guide, and when running into the bending place of blood vessel, self can bend according to the bending degree of blood vessel, thus guides whole pipe guide smoothly by the bending place of blood vessel; Guard block 105 can be the relatively soft soft head of one section of material or spring, is socketed on the far-end of electrode load bearing component 102, avoids the far-end injured blood vessel of electrode load bearing component 102.Material for the protection of the spring of parts 105 generally selects Ni-Ti or stainless steel alloy, and pitch is closing twist, can meet aeroelastic requirements; Length is 25-50mm.Also spiral external diameter can be selected to be the spring of 0.25-0.6mm.Also the diameter of spring wire can be selected to be 0.045-0.12mm.
Pipe guide in this detailed description of the invention also comprises the control line 104 for the shape of control electrode load bearing component 102.The far-end of control line 104 is connected on the remote point of electrode load bearing component 102.Control line 103 generally adopts tinsel.In the preferred embodiment, tinsel adopts NiTi or stainless steel material; Diameter is between 0.1 ~ 0.38mm.Further, far-end wiry wants soft, is not injured to protect blood vessel by ablation catheter.In addition, control line 103 can also adopt macromolecular material to make, and the macromolecular material for the manufacture of control line 103 comprises High molecular weight polyethylene UHMWPE, polyethylene PP, nylon Nylon or PVOH amine PGA etc.
Further, conveniently use the shape of control line 104 control electrode load bearing component 102, the surface of electrode load bearing component 102 is cut.Control line 104 control electrode load bearing component 102, makes it have the first shape or the second shape: when control line 104 is in releasing orientation, electrode load bearing component 102 is in the first shape; When control line 104 is in tension, be in the second shape.
In the present embodiment, the work process of multi-electrode radio frequency ablation catheter for renal artery is as follows:
Control line 104 is first placed in releasing orientation by 1, and namely electrode load bearing component 102 is in the first shape;
The electrode load bearing component 102 of ablation catheter to be moved the renal sympathetic nerve place on the pure man renal artery by 2;
Control line 104 is placed in tension by 3, electrode load bearing component 102 is made to become spiral type from straight, electrode 101 on electrode load bearing component 102, be close to the nerve that blood vessel acts on relevant position, discharge certain energy thus play the effect regulating this neural site (such as, reduce or eliminate orthosympathetic activation);
Control line 104 is placed in releasing orientation by 4 again, and electrode load bearing component 52 becomes the first shape from the second shape;
Ablation catheter is shifted out human body by 5.
Electrode load bearing component 102 surface is according to cutting angle, be cut into straight-line groove, multiple oval groove, multiple dumb-bell slot or multiple cylindrical groove, specifically as shown in Fig. 6-Figure 12 from the far-end of electrode load bearing component to the near-end of electrode load bearing component.Horizontal positioned electrode load bearing component 102, if be cut into straight-line groove, cutting angle is exactly the angle α of straight line and horizontal direction; If be cut into multiple oval groove, multiple dumb-bell slot or multiple cylindrical groove, cutting angle is exactly the line between the central point of oval groove, dumb-bell slot or cylindrical groove and the angle α in horizontal direction.
In a preferred embodiment of the present invention, electrode load bearing component surface cuts into straight-line groove according to cutting angle, specifically as shown in Figure 6 and Figure 7.On the surface of electrode load bearing component, the straight-line groove shown in Fig. 6 be with the cutting angle of α=53 °, from the far-end of electrode load bearing component to the near-end of electrode load bearing component, carry out cutting according to straight line and formed.Wherein, the cutting width of straight line is between 0.2449mm ~ 0.6566mm, and the cutting angle of the straight-line groove shown in Fig. 6 on electrode load bearing component is consistent.Straight-line groove shown in Fig. 7 is divided into two parts: a part is with the cutting angle of α=53 °, is formed from the far-end of electrode load bearing component, according to straight cuts; Another part is when near electrode load bearing component near-end, progressively reduces cutting angle (α '), and according to the cutting angle progressively reduced (α ') until the near-end of electrode load bearing component, to be formed according to straight cuts.Further, the straight-line groove near electrode load bearing component proximal end is also provided with some bending 701, to increase the torsion of control pair electrode load bearing component.
In a preferred embodiment of the present invention, electrode load bearing component surface cuts into dumb-bell slot according to cutting angle, specifically as shown in Figure 8 and Figure 9:
As shown in Figure 8, on electrode load bearing component, dumb-bell slot is with the cutting angle of α=33 °, according to the cutting interval (horizontal intervals of adjacent two cylindrical grooves) of d=0.7150mm, proximally carries out cutting formed with the dumb-bell slot perpendicular to horizontal direction from the far-end of electrode load bearing component.The centre of each dumbbell groove has the projection in x opposite direction near the position at two ends;
As shown in Figure 9, on electrode load bearing component, dumb-bell slot is with the cutting angle of α=43 °, according to the cutting interval of d=0.8150mm, proximally carries out cutting formed with the dumb-bell slot perpendicular to horizontal direction from the far-end of electrode load bearing component.
In a preferred embodiment of the present invention, electrode load bearing component surface cuts into multiple cylindrical groove according to cutting angle, specifically as shown in Figure 10:
As shown in Figure 10, on electrode load bearing component, multiple cylindrical groove is with the cutting angle of α=30 °, proximally carries out cutting formed with cylindrical groove from the far-end of electrode load bearing component.This cylindrical groove is cylindrical, and the height of each cylindrical groove and horizontal direction are 30 ° of angles.
In another preferred embodiment of the present invention, electrode load bearing component surface cuts into oval groove according to cutting angle, specifically as is illustrated by figs. 11 and 12.In Figure 11 and Figure 12, on electrode load bearing component, oval groove is all with the cutting angle of α=30 °, with oval groove, proximally carries out cutting formed from the far-end of electrode load bearing component; Wherein, the major axis of each oval groove is 0.504mm, and minor axis is 0.4mm.In the oval groove shown in Figure 11, the major axis of each oval groove and horizontal direction are all in 30 ° of angles.In the oval groove shown in Figure 12, the major axis of each oval groove is vertical with horizontal direction.
In addition, in this specific embodiment, in order to user grips conveniently, pipe guide also comprises the handle 201 being suitable for user and gripping, and control line 104, transfer unit 103 and wire 301 are installed on handle 201.Independently two parts that handle 201 and the connection cord of external energy generator are set to one or are connected by conversion port.Further, handle 201 can by unclamping and straining the shape that control line 104 controls the electrode load bearing component 102 of far-end.Handle 201 carrys out control electrode 101 by wire 301, and handle 201 both can control multiple electrode and release energy simultaneously, also can select to control an independent electrode and release energy.
The foregoing describe provided by the invention for regulating the detailed description of the invention of neural device.Be to be understood that, those of ordinary skill in the art just design according to the present invention can make many modifications and variations without the need to creative work, as long as this adjusting part can be transported to the neural site regulated near needs via blood vessel, and operational shape control assembly makes electrode load bearing component change between the first shape and the second shape, just can realize the object of neuroregulation and treatment.Such as, application number some schemes disclosed by the Chinese patent application of 200780031879.4 and 200980157662.7 can be used for reference and realize this object, provided device specifically can be adopted to drive the motion of shape controlling parts.Therefore, all those skilled in the art, all should by the determined protection domain of claims under this invention's idea on the basis of existing technology by the available technical scheme of logical analysis, reasoning, or a limited experiment.
More than describe preferred embodiment of the present invention in detail.Should be appreciated that the ordinary skill of this area just design according to the present invention can make many modifications and variations without the need to creative work.Therefore, all technical staff in the art, all should by the determined protection domain of claims under this invention's idea on the basis of existing technology by the available technical scheme of logical analysis, reasoning, or a limited experiment.
Claims (10)
1. a multi-electrode radio frequency ablation catheter for renal artery, comprises electrode load bearing component, transfer unit and multiple electrode;
Described multiple electrode is set to adjusting energy to be delivered to nerve;
Described electrode load bearing component is set to carry described multiple electrode;
Described transfer unit is set to described electrode load bearing component is transported to the position near described nerve;
Described electrode is connected with wire;
Described electrode load bearing component has the first shape and the second shape: under described first shape, and described electrode load bearing component is set to be suitable for moving in the blood vessel; Under described second shape, described electrode load bearing component is set to be suitable for, by described multiple electrode, adjusting energy is delivered to described nerve;
It is characterized in that, also comprise control line, described control line is arranged on the inside of described electrode load bearing component and described transfer unit; The far-end of described control line is connected with the far-end of described electrode load bearing component;
The surface of described electrode load bearing component is cut, and enables described control line control described electrode load bearing component and switches between described first shape and described second shape.
2. multi-electrode radio frequency ablation catheter for renal artery as claimed in claim 1, wherein, when described control line is in releasing orientation, described electrode load bearing component is in described first shape; When described control line is in tension, described electrode load bearing component is in described second shape.
3. multi-electrode radio frequency ablation catheter for renal artery as claimed in claim 1, wherein, described electrode load bearing component surface is according to cutting angle cutting straight line groove.
4. multi-electrode radio frequency ablation catheter for renal artery as claimed in claim 1, wherein, multiple oval groove, multiple dumb-bell slot or multiple cylindrical groove are cut according to cutting angle in described electrode load bearing component surface.
5. multi-electrode radio frequency ablation catheter for renal artery as claimed in claim 1, wherein, described transfer unit is the tubular structure of hollow.
6. multi-electrode radio frequency ablation catheter for renal artery as claimed in claim 1, wherein, described electrode load bearing component and described transfer unit are integral types.
7. multi-electrode radio frequency ablation catheter for renal artery as claimed in claim 1, wherein, described first shape of described electrode load bearing component is straight or approximate straight; Described second shape of described electrode load bearing component is spiral type or approximate spiral.
8. multi-electrode radio frequency ablation catheter for renal artery as claimed in claim 1, wherein, described pipe guide also comprises Control Component, and described Control Component comprises the handle gripped for user, and described handle is connected with described transfer unit.
9. multi-electrode radio frequency ablation catheter for renal artery as claimed in claim 8, wherein, described control line and described wire are installed in described handle.
10. multi-electrode radio frequency ablation catheter for renal artery as claimed in claim 9, wherein, described handle controls described first shape of described electrode load bearing component and described second shape by described control line:
When described control line strained by described handle, described electrode load bearing component is in described second shape;
When described in described handle lock during control line, described electrode load bearing component is in described first shape.
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| CN201410280798.XA CN105167840A (en) | 2014-06-20 | 2014-06-20 | Multi-electrode renal artery radiofrequency ablation catheter |
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| CN201410280798.XA CN105167840A (en) | 2014-06-20 | 2014-06-20 | Multi-electrode renal artery radiofrequency ablation catheter |
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| CN105167840A true CN105167840A (en) | 2015-12-23 |
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| CN201410280798.XA Pending CN105167840A (en) | 2014-06-20 | 2014-06-20 | Multi-electrode renal artery radiofrequency ablation catheter |
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| US9855096B2 (en) | 2012-05-11 | 2018-01-02 | Medtronic Ardian Luxembourg S.A.R.L. | Multi-electrode catheter assemblies for renal neuromodulation and associated systems and methods |
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| US10076382B2 (en) | 2010-10-25 | 2018-09-18 | Medtronic Ardian Luxembourg S.A.R.L. | Catheter apparatuses having multi-electrode arrays for renal neuromodulation and associated systems and methods |
| CN111067617A (en) * | 2019-12-27 | 2020-04-28 | 苏州恒瑞宏远医疗科技有限公司 | Radio frequency closure catheter and method of making same |
| US10736690B2 (en) | 2014-04-24 | 2020-08-11 | Medtronic Ardian Luxembourg S.A.R.L. | Neuromodulation catheters and associated systems and methods |
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| CN113633373A (en) * | 2021-08-02 | 2021-11-12 | 上海安通医疗科技有限公司 | Radial artery puncture ablation catheter |
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