CN106175975A - A kind of Powder aerosol dynamic formula per os nasal inhalation contamination device - Google Patents

A kind of Powder aerosol dynamic formula per os nasal inhalation contamination device Download PDF

Info

Publication number
CN106175975A
CN106175975A CN201610541458.7A CN201610541458A CN106175975A CN 106175975 A CN106175975 A CN 106175975A CN 201610541458 A CN201610541458 A CN 201610541458A CN 106175975 A CN106175975 A CN 106175975A
Authority
CN
China
Prior art keywords
powder
exposure chamber
aerosol
bubbler
animal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CN201610541458.7A
Other languages
Chinese (zh)
Other versions
CN106175975B (en
Inventor
于云江
刘红杰
王琼
向明灯
苏凯华
汪正东
张艳平
李良忠
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Matt Beijing Hi Tech Technology Co Ltd
Chinese Research Academy of Environmental Sciences
Original Assignee
Matt Beijing Hi Tech Technology Co Ltd
Chinese Research Academy of Environmental Sciences
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Matt Beijing Hi Tech Technology Co Ltd, Chinese Research Academy of Environmental Sciences filed Critical Matt Beijing Hi Tech Technology Co Ltd
Priority to CN201610541458.7A priority Critical patent/CN106175975B/en
Publication of CN106175975A publication Critical patent/CN106175975A/en
Application granted granted Critical
Publication of CN106175975B publication Critical patent/CN106175975B/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61DVETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
    • A61D7/00Devices or methods for introducing solid, liquid, or gaseous remedies or other materials into or onto the bodies of animals
    • A61D7/04Devices for anaesthetising animals by gases or vapours; Inhaling devices

Abstract

The present invention relates to a kind of Powder aerosol dynamic formula per os nasal inhalation contamination device, this contamination device includes exposure chamber, fixing device for experimental animal, air compressor, powder bubbler, diffusive gas flow pipeline, rapping apparatus, dust aerosol sample channel, opposite-flushing type mixing room, the dilution air flow that liquidates pipeline, blower fan, microcomputer control unit, powder bubbler is for solving quantitatively spraying and diffusion problem of solid tested material powder, powder bubbler is connected to opposite-flushing type mixing room by dust aerosol sample channel, the top of exposure chamber is fixed in opposite-flushing type mixing room, connect with exposure chamber inside, exposure chamber is provided with exposure chamber interface, the front end of fixing device for experimental animal is connected with exposure chamber by exposure chamber interface, microcomputer control unit is for regulating and controlling the operational factor of contamination device.Invention emulates the Powder aerosol exposure chamber in actual environment, tested material uniform concentration distribution, exposed state is stable, and experimental result is reproducible, and facility swift to operate is applied widely.

Description

A kind of Powder aerosol dynamic formula per os nasal inhalation contamination device
Technical field
The present invention relates to a kind of experimental provision, particularly relate to a kind of Powder aerosol dynamic formula per os nasal inhalation contamination device.
Background technology
Existing Powder aerosol sucks exposure contamination equipment mainly has the suction of quiet formula to expose contamination and dynamic formula suction exposure Contaminate two kinds.Quiet formula sucks the shortcoming of exposure toxicant exposure cabinet: in toxicant exposure cabinet, tested material concentration is gradually reduced (molten for powder gas Glue, due to settlement action, its concentration can substantially reduce);Laboratory animal has the probability through skin absorption;Along with entering of experiment OK, decrease in oxygen partial pressure is obvious.The shortcoming of existing dynamic inhalation contamination equipment is: tested material is with including the form of Powder aerosol Flow at high speed in the pipeline that footpath is less, does not meets the exposure chamber of actual environment, and the amount simultaneously consuming tested material is bigger;For stream The powder (easily piling up and caking) that dynamic property is bad, it is impossible to realize fixing quantity exactly, and be likely to result in pipeline blockage;Structure Complex with control, it is difficult to operation.
Summary of the invention
The present invention be directed to above-mentioned the deficiencies in the prior art, and design a kind of Powder aerosol dynamic formula per os snuffing of assembling Enter to expose contamination device.
The invention provides a kind of Powder aerosol dynamic formula per os nasal inhalation contamination device, it is characterised in that described contamination Device includes exposure chamber, fixing device for experimental animal, air compressor, powder bubbler, diffusive gas flow pipeline, rapping apparatus, powder Dust and gas colloidal sol sample channel, opposite-flushing type mixing room, the dilution air flow that liquidates pipeline, blower fan, microcomputer control unit;
Described air compressor is connected with described powder bubbler by described diffusive gas flow pipeline,
Described powder bubbler, for solving quantitatively spraying and diffusion problem of solid tested material powder, fills with described rapping Putting and connected by vertical axle, described rapping apparatus carrys out the upright of disintegrate powder by rapping and piles up and caking phenomenon, thus protects Demonstrate,proving the fixing quantity of described powder bubbler, described powder bubbler is connected to described by described dust aerosol sample channel Opposite-flushing type mixing room,
The top of described exposure chamber is fixed in described opposite-flushing type mixing room, in described opposite-flushing type mixing room and described exposure chamber Portion connects, described opposite-flushing type mixing room pass through described in the dilution air flow pipeline that liquidates be connected with described air compressor,
Surrounding sidewall around described exposure chamber is provided with exposure chamber interface, and institute is passed through in the front end of described fixing device for experimental animal State exposure chamber interface to be connected with described exposure chamber,
The bottom of described exposure chamber is connected with described blower fan by pipeline,
Described microcomputer control unit is for regulating and controlling the operational factor of described contamination device.
Further, described contamination device also includes main cabinet, exhaust purifier, parameter display unit, described main cabinet Body has base plate, middle level dividing plate, top board, four columns, and described air compressor is placed in outside described main cabinet, and described powder spreads Device and described rapping apparatus are individually fixed in inside and outside the top of described main cabinet;Described exposure chamber is fixed on described main cabinet On the middle level dividing plate of body;Described exhaust purifier, described microcomputer control unit and described parameter display unit be fixed on described in On crossbeam under layer dividing plate, described blower fan is fixed on the base plate of described main cabinet, four column bottom dresses of described main cabinet Joining universal wheel, described exhaust purifier is connected with the bottom of described exposure chamber by pipeline, and described parameter display unit is used for showing Show running status and the parameter of described contamination device.
Further, described exposure chamber is the barrel-shaped structure of big volume, major diameter, and lower end connects has taper dust to receive Storage, exposure chamber interface takes staggered arrangement, described exposure chamber interface to be furnished with blind plate, can be with occluding member interface.
Further, described fixing device for experimental animal includes movable carriage, elastic reducing-fixing band, animal accommodation chamber, work Dynamic baffle plate, feces urine collector, described animal accommodation chamber transparent organic glass makes, and its front end is to fit mutually with animal head The tapered conical bucket answered;The main part of described animal accommodation chamber is barrel-shaped cylinder, and different in width is all arranged at its top and bottom Open slot, open top groove is for the movement of described sideboard and fixing, and the open slot of bottom is easy to the excrement of animal excretion Just urine enters the described feces urine collector that is connected with described animal accommodation chamber, the bottom outfit of described animal accommodation chamber and The latch that described feces urine collector upper groove is supporting, is coordinated by described groove and described latch, facilitates described feces to urinate The installation of collection and disassembly, cleaning;Described sideboard is by can the nut of degree of tightness and have certain thickness circular baffle plate group Become, have the curved surface adapted with animal buttocks inside the circular baffle plate of its configuration and animal tail can be allowed through described sideboard Circular hole;
Described contamination device also includes that the first support, described movable carriage are placed in the relevant position of described first support Place, the main body of described fixing device for experimental animal is placed in on mounted described movable carriage, with on described movable carriage Described fixing device for experimental animal is fixed by the described elastic reducing-fixing band of configuration.
Further, described first support be followed successively by from top to bottom the base by stainless steel substrates material, lower floor, middle level and Upper strata, is fixed by threaded rod and nut between each layer, and every layer height adapts with the height of exposure chamber interface.
Further, described powder bubbler includes that electromagnetic valve, aerosol apparatus, medicine bottle, described diffusive gas flow pipeline pass Described electromagnetic valve is connected with described aerosol apparatus;Described medicine bottle is fixed on described aerosol apparatus by screw thread and sealing gasket;Described spray Day with fog is connected with described opposite-flushing type mixing room by described Powder aerosol sample channel, is sent by certain density Powder aerosol Enter described opposite-flushing type mixing room;Described microcomputer control unit is connected with described electromagnetic valve by data wire.
Further, described aerosol apparatus includes inner sleeve, sheath trachea, and described aerosol apparatus uses double gas circuit structure, compression Air is divided into two-way after described diffusive gas flow pipeline enters described aerosol apparatus, and a road opens below into bottom described medicine bottle, by powder Shape medicine blows afloat, and sprays outward from described inner sleeve;Another road air-flow is walked around from sheath trachea described in top, outside described inner sleeve Form parcel sheath gas.The powdered drug composition that described sheath gas and described inner sleeve are sent is that mixed airflow is sent, further outward Enter opposite-flushing type mixing room.
Further, described rapping apparatus includes electric magnet, cover plate, back-moving spring, the second support, and described cover plate is the most whole The top board of individual toxicant exposure cabinet, described electric magnet is fixed on described cover plate;Four threaded rods that described second support is equipped with by it Being fixed on described cover plate, the vibrating shaft on described electric magnet passes described cover plate and the circular hole of described second carriage center and institute State the firm connection of aerosol apparatus;Screwed stainless steel shaft it is installed with, on described second support in the middle of described back-moving spring Circular hole is firm with described aerosol apparatus to be connected.
Further, described opposite-flushing type mixing room has mixing chamber, and described mixing chamber communicates with described exposure chamber, described The mouth of pipe of dust aerosol sample channel and the described dilution air flow pipeline mouth of pipe that liquidates are positioned at the middle in described mixing chamber, and on The most relatively, internal diameter is in the same size.
A kind of control method of the Powder aerosol dynamic formula per os nasal inhalation contamination device of the present invention, it is characterised in that
Step 1, open the main power being positioned at microcomputer control unit, now microcomputer control unit, parameter display unit and Blower fan is in energising operating condition, and the program of microcomputer control unit is set to " standby " pattern, then according to the parameter of display, Set the compressor flow of requirement of experiment;Open power supply and the air delivery valve thereof of air compressor, and output pressure is set.
Step 2, under equipment is in " standby " mode state, take off the dress sample bottle being positioned on powder bubbler, will be appropriate After powdered samples loads dress sample bottle, then install back on powder bubbler;To be run entering is selected at microcomputer control unit After sample program, choose whether to run rapping apparatus according to the character of given the test agent powder;Now, contamination equipment starts according to target The parameter operation that exposure concentrations is corresponding.
Run " cleaning " program of microcomputer control unit before step 3, shutdown, after treating that this program is run, close air Compressor and air delivery valve thereof, finally close main power.
The beneficial effects of the present invention is:
(1) exposure chamber of the present invention uses big volume, the barrel-like structure of major diameter, and the sedimentation of dust is similar in air The natural subsidence of grain thing, simulates the Powder aerosol exposure chamber in actual environment.
(2) exposure chamber interface takes rational staggered arrangement, both can guarantee that experiment capacity, can prevent from again mutually covering dry Disturb, advantageously ensure that the concordance of laboratory animal exposed environments.Interface is furnished with blind plate, can block part of interface, conveniently carry out The experiment of (laboratory animal quantity) more on a small scale.
(3) powder bubbler can stably realize the quantitative sprinkling of powder medicaments, and opposite-flushing type mixing room can guarantee that exposure Tested material uniform concentration distribution in room, exposed state is stable, and after laboratory animal exposes contamination, experimental result is reproducible.
(4) present invention can control the ventilation rate of exposure chamber easily by changing compressor flow, keeps suitable oxygen simultaneously Dividing potential drop;By adjusting the parameters such as the pressure of air-flow, flow, sprinkling frequency and ventilation rate, reach in dosage and exposure chamber The control of tested material concentration, facility swift to operate;Re-scaling by adjusting parameter, the rapping apparatus of outfit can ensure that difference The quantitative sprinkling of the powder tested material of flow behavior, applied widely.
Accompanying drawing explanation
Fig. 1 is a kind of Powder aerosol dynamic formula per os nasal inhalation contamination device structural representation of the present invention;
Fig. 2 is exposure chamber schematic diagram in the present invention;
Fig. 3 is exposure chamber fixing device for experimental animal in the present invention, holder combination schematic diagram;
Fig. 4 is medium-height trestle schematic diagram of the present invention;
Fig. 5 is fixing device for experimental animal STRUCTURE DECOMPOSITION schematic diagram in the present invention;
Fig. 6 is fixing device for experimental animal combination schematic diagram in the present invention;
Fig. 7 is rapping apparatus structural representation in the present invention;
Fig. 8 is powder bubbler floor map in the present invention;
Fig. 9 is powder bubbler internal sprayer sectional view in the present invention;
Figure 10 is opposite-flushing type mixing cell structure schematic diagram in the present invention.
Wherein: 1, main cabinet, 2, exposure chamber, 3, exposure chamber interface, 4, fixing device for experimental animal, 5, support, 6, air pressure Contracting machine, 7, powder bubbler, 8, diffusive gas flow pipeline, 9, rapping apparatus, 10, dust aerosol sample channel, 11, opposite-flushing type mixes Even room, 12, the dilution air flow that liquidates pipeline, 13, exhaust purifier, 14, blower fan, 15, microcomputer control unit, 16, parameter display single Unit, 17, movable carriage, 18, elastic reducing-fixing band, 19, animal accommodation chamber, 20, sideboard, 21, feces urine collector, 22, latch, 23, circular hole, 24, electric magnet, 25, cover plate, 26, back-moving spring, 27, support, 28, electromagnetic valve, 29, aerosol apparatus, 30, Medicine bottle, 31, data wire, 32, inner sleeve, 33, sheath trachea, 34, powdered drug, 35, sheath gas, 36, mixed airflow, 37, mixing chamber.
Detailed description of the invention
Below with reference to accompanying drawing 1-10, technical scheme is described in detail.
As it is shown in figure 1, the invention provides a kind of Powder aerosol dynamic formula per os nasal inhalation contamination device, including: main cabinet Body 1, exposure chamber 2, exposure chamber interface 3, fixing device for experimental animal 4, support 5, air compressor 6, powder bubbler 7, diffusion gas Flow tube road 8, rapping apparatus 9, dust aerosol sample channel 10, opposite-flushing type mixing room 11, the dilution air flow that liquidates pipeline 12, tail gas Depurator 13, blower fan 14, microcomputer control unit 15, parameter display unit 16.
As it is shown in figure 1, air compressor 6 is placed in outside main cabinet 1, powder bubbler 7 passes through vertical axle with rapping apparatus 9 Connect, and be individually fixed in inside and outside the top of main cabinet 1;Exposure chamber 2 is fixed on the middle level dividing plate of main cabinet 1;Tail Gas purifier 13, microcomputer control unit 15 and parameter display unit 16 are fixed on the crossbeam under the dividing plate of middle level, and blower fan 14 is fixed On the base plate of main cabinet 1, four column bottom assembling universal wheels of main cabinet 1, it is simple to contamination device moves.
Air compressor 6 is used for providing clean compressed air, is connected with powder bubbler 7 by diffusive gas flow pipeline 8, will Clean compressed air sends into powder bubbler 7;By liquidating, dilution air flow pipeline 12 is connected, by cleaning with opposite-flushing type mixing room 11 Compressed air sends into opposite-flushing type mixing room 11.
Powder bubbler 7 is connected with opposite-flushing type mixing room 11 by dust aerosol sample channel 10.
The bottom of exposure chamber 2 is connected with exhaust purifier 13 by pipeline, and exhaust purifier 13 is connected with blower fan 14.Blower fan 14 for extracting the mixed gas in exposure chamber 2 out, and mixed gas is sent into exhaust purifier 13 purify.Blower fan 14 was both protected Demonstrate,prove the air circulation in exposure chamber 2, provide suitable partial pressure of oxygen for exposure chamber 2, waste gas can have been tested again after purifying and send into real Test chamber ventilated system.
Microcomputer control unit 15 is for controlling the operation of described contamination device.
Parameter display unit 16 is used for showing described contamination device running status and parameter.
As in figure 2 it is shown, the barrel-shaped structure that exposure chamber 2 is big volume, major diameter, the sedimentation of dust is similar in air The natural subsidence of grain thing, the exposure chamber in simulation actual environment, lower end connects taper dust collection, exposure chamber interface 3 It is circumferentially positioned on the surrounding sidewall of exposure chamber 2, and takes rational staggered arrangement, both can guarantee that experiment capacity, and can prevent again Mutually cover interference, advantageously ensure that the concordance of laboratory animal exposed environments.Exposure chamber interface 3 is furnished with blind plate, can block Part of interface, conveniently carries out the experiment of (laboratory animal quantity) more on a small scale.
Support 5 is placed on the middle level dividing plate of main cabinet 1 and around exposure chamber 2, as it is shown on figure 3, be made with rustless steel, Fixing device for experimental animal 4 can be fixed on support 5 by movable carriage 17 and its subsidiary elastic reducing-fixing band 18;Such as Fig. 4 Shown in, support 5 is followed successively by the base of stainless steel substrates material, lower floor, middle level and upper strata from top to bottom, passes through threaded rod between each layer Fixing with nut, every layer height adapts with the height of exposure chamber interface 3, in order to the most fixing fixing device for experimental animal 4.
Fixing device for experimental animal 4 is fixed on support 5, and exposure chamber interface 3 is passed through with sudden and violent in the front end of fixing device for experimental animal 4 Dew room 2 connects.As it is shown in figure 5, fixing device for experimental animal 4 includes movable carriage 17, elastic reducing-fixing band 18, animal accommodation chamber 19, sideboard 20, feces urine collector 21.Animal accommodation chamber 19 transparent organic glass makes, and its front end is and animal The tapered conical bucket that head adapts;The main part of animal accommodation chamber 19 is barrel-shaped cylinder, and its top and bottom all have not With the open slot of width, open top groove is used for the movement of sideboard 20 and fixes, and the open slot of bottom is easy to animal excretion Feces urine enter the feces urine collector 21 that is connected with animal accommodation chamber 19, bottom outfit and feces urine collector 21 The latch 22 that upper groove is supporting, is coordinated by groove and latch 22, facilitates installation and the disassembly, cleaning of feces urine collector 21; Sideboard 20 by can the nut of degree of tightness and there is certain thickness circular baffle plate form, have inside the circular baffle plate of its configuration with Curved surface that animal buttocks adapts and can allow the circular hole 23 that animal tail passes.Movable carriage 17 is placed in the corresponding positions of support 5 Putting place, the main body of fixing device for experimental animal 4 is placed in, on mounted movable carriage 17, as shown in Figure 6, to use movable carriage On 17, the elastic reducing-fixing band 18 of configuration is by fixing device for experimental animal 4 fix tightly;By laboratory animal from the tail of fixing device for experimental animal 4 Put into animal accommodation chamber 19 at end opening, fixing sideboard 20 is installed and arrives appropriate location, make the mouth and nose of animal stretch out animal and hold Receive the front end in cabin 19, to contact exposed environments, and by the tail of laboratory animal through the circular hole 23 on sideboard 20.
The effect of rapping apparatus 9 is that carrying out the upright of disintegrate powder by rapping piles up and caking phenomenon, thus ensures The fixing quantity of powder bubbler 7, expands the scope of application of bubbler, and rapping apparatus 9 is mainly by electric magnet 24, cover plate 25, multiple Position spring 26, support 27 are constituted, as it is shown in fig. 7, the top board of that is whole toxicant exposure cabinet of cover plate 25, electric magnet 24 is fixed by screws in On cover plate 25;Support 27 is fixed on cover plate 25 by its four threaded rods being equipped with, and the vibrating shaft on electric magnet 24 is through lid Plate 25 and the circular hole at support 27 center, consolidate with aerosol apparatus 29 and be connected;It is installed with screwed rustless steel in the middle of back-moving spring 26 Axle, the circular hole on support 27, consolidate with aerosol apparatus 29 and be connected.When electric magnet 24 is energized, vibrating shaft carries, back-moving spring 26 Compression;During electric magnet 24 power-off, vibrating shaft moves down, and back-moving spring 26 resets;By electric magnet 24 adhesive make with on aerosol apparatus 29 Medicine bottle 30 move up, after electric magnet 24 power-off aerosol apparatus 29 reset under the effect of back-moving spring 26 formation rapping effect, The upright of disintegrate powder is piled up and caking;By regulating time controller, control the rapping frequency of device, device can be made to be suitable for In the powder of different mobility, simultaneously because back-moving spring 26 has certain cushioning effect, be unlikely to cause medicine bottle 30 due to High vibration and come off.Additionally, rapping program is relevant with sample introduction frequency, during general twice sample introduction, rapping is once, can be according to being subject to Examination thing characteristic makes corresponding change.
Powder bubbler 7 is for solving the quantitative sprinkling problem of drug powder, and as shown in Figure 8, powder bubbler 7 includes electricity Magnet valve 28, aerosol apparatus 29, medicine bottle 30.Diffusive gas flow pipeline 8, through electromagnetic valve 28, is connected with aerosol apparatus 29;Medicine bottle 30 passes through spiral shell Stricture of vagina and sealing gasket are fixed on aerosol apparatus 29, can dismantle at any time and vary;The Powder aerosol sample channel being connected with aerosol apparatus 29 10, it is connected with opposite-flushing type mixing room 11 further, certain density Powder aerosol is sent into opposite-flushing type mixing room 11;Microcomputer control Unit 15 processed is connected with electromagnetic valve 28 by data wire 31, is used for controlling rapping frequency, by data wire 31 with electromagnetic valve 28 even Connect, be used for controlling compressed air stream, control sample introduction frequency and sample size further.Microcomputer control unit 15 is mainly by inside it Single-chip microcomputer in injection procedure and rapping program, control sample introduction frequency and rapping frequency.According to Powder aerosol in exposure chamber Concentration requirement and the settlement law of particulate matter, by calculating and debugging, obtain injection procedure corresponding to each Concentraton gradient and rapping Program, by the download program of acquisition to microcomputer control unit 15, can operationally select different aerosol concentration corresponding Program.
Aerosol apparatus 29 includes inner sleeve 32, sheath trachea 33.Aerosol apparatus 29 uses double gas circuit structure, air-flow details such as Fig. 9 institute Showing: compressed air is divided into two-way after diffusive gas flow pipeline 8 enters aerosol apparatus 29, a road opens below into bottom medicine bottle 30, by powder Shape medicine 34 blows afloat, and forms high concentration Powder aerosol, sprays outward from inner sleeve 32;Another road air-flow from top sheath trachea 33 around Cross, outside inner sleeve 32, form parcel sheath gas 35.The powdered drug composition that sheath gas 35 and inner sleeve 32 are sent is mixed airflow 36 send outward, travel further into opposite-flushing type mixing room 11.The design of sheath gas 35 desirably prevents Powder aerosol sample channel 10 blockings.The present invention can be used for solving the accumulation agglomeration problems of lazy flow powder, it is ensured that the stability of sprinkling.
In this enforcement, opposite-flushing type mixing room 11 is passed through flange (shimming sealing) and is fixed on the top of exposure chamber 2, both Inside is connection, and as shown in Figure 10, opposite-flushing type mixing room 11 has mixing chamber 37, and mixing chamber 37 communicates with exposure chamber 2, dust The mouth of pipe of aerosol sample channel 10 and dilution air flow pipeline 12 mouth of pipe that liquidates are positioned at the middle in mixing chamber 37, and phase up and down In the same size to, internal diameter.
Clean gas flow, successively through diffusive gas flow pipeline 8 and electromagnetic valve 28, enters in powder bubbler 7, will be stored in sample Solid tested material powder diffusion in bottle 30, then passes through Powder aerosol sample channel 10 and liquidates in dilution air flow pipeline 12 Clean gas mixing chamber 37 in carry out opposite-flushing type dilution diffusion.
The operational factor of the Powder aerosol dynamic formula per os nasal inhalation contamination device of the present invention is adjusted by microcomputer control unit 15 Control, running status and supplemental characteristic are shown by parameter display unit 16;
Present invention also offers the control method of a kind of Powder aerosol dynamic formula per os nasal inhalation contamination device, it specifically wraps Include:
Step 1, opening the main power being positioned at microcomputer control unit 15, now microcomputer control unit 15, parameter display is single Unit 16 and blower fan 14 are in energising operating condition, and the program of microcomputer control unit 15 is set to " standby " pattern, then according to The parameter of display, sets the compressor flow of requirement of experiment;Open power supply and the air delivery valve thereof of air compressor 6, and output is set Air pressure.
Step 2, under equipment is in " standby " mode state, take off the dress sample bottle being positioned on powder bubbler 7, will be appropriate After powdered samples loads dress sample bottle, then install back on powder bubbler 7;Select to be run at microcomputer control unit 15 After injection procedure, choose whether to run rapping apparatus 9 according to the character of given the test agent powder;Now, contamination equipment start according to The parameter operation that target exposure concentration is corresponding.
Run " cleaning " program of microcomputer control unit 15 before step 3, shutdown, after treating that this program is run, close sky Air compressor 6 and air delivery valve thereof, finally close main power.
All operational factors of this device show in parameter display unit 16, operational factor be arranged on microcomputer control unit It is configured at 15.After selecting a certain program to run, powdered samples is quantitatively sent by powder bubbler 7, more molten through dust gas Glue sample channel 10 enters opposite-flushing type mixing room 11, and powdered samples is in the mixing room 11 that liquidates and after the dilution air flow effect that liquidates Form Powder aerosol, subsequently enter exposure chamber 2.Laboratory animal is placed in fixing device for experimental animal 4, fixing device for experimental animal 4 are placed on supporting support 5, and the snoot of animal stretches out the front end circular hole of fixing device for experimental animal 4 and is exposed to exposure chamber 2 In, complete to expose purpose.Clean gas flow required during plant running is provided by air compressor 6, the tail gas that experimentation produces Through exhaust purifier 13 purified treatment heel row to laboratory ventilation system.
Additionally, the present invention is in addition to exposing exposure experiment for Powder aerosol dynamic formula per os nasal inhalation, it may also be used for liquid Aerosol dynamic formula per os nasal inhalation exposes exposure experiment, and the powder bubbler 7 in Fig. 1 and connection opposite-flushing type thereof are mixed room 11 Sample feeding pipe, is replaced as liquid atomiser (liquid aersol generator) and supporting sample feeding pipe thereof, by adjust air-flow pressure, Flow, sprinkling frequency, ventilation rate etc. control parameter, reach dosage and the control of tested material concentration in exposure chamber.
Although the principle of the present invention being described in detail above in conjunction with the preferred embodiments of the present invention, this area skill Art personnel are it should be understood that above-described embodiment is only the explanation of the exemplary implementation to the present invention, not to bag of the present invention Restriction containing scope.Details in embodiment is not intended that limitation of the scope of the invention, without departing substantially from the present invention spirit and In the case of scope, any equivalent transformation based on technical solution of the present invention, simple replacement etc. obviously change, and all fall within Within scope.

Claims (10)

1. a Powder aerosol dynamic formula per os nasal inhalation contamination device, it is characterised in that described contamination device includes exposure chamber (2), fixing device for experimental animal (4), air compressor (6), powder bubbler (7), diffusive gas flow pipeline (8), rapping apparatus (9), dust aerosol sample channel (10), opposite-flushing type mixing room (11), the dilution air flow that liquidates pipeline (12), blower fan (14), micro- Machine control unit (15);
Described air compressor (6) is connected with described powder bubbler (7) by described diffusive gas flow pipeline (8),
Described powder bubbler (7), for solving quantitatively spraying and diffusion problem of solid tested material powder, fills with described rapping Putting (9) to be connected by vertical axle, described rapping apparatus (9) carrys out the upright of disintegrate powder by rapping and piles up and caking phenomenon, Thus ensureing the fixing quantity of described powder bubbler (7), described powder bubbler (7) passes through described dust aerosol sample feeding pipe Road (10) is connected to described opposite-flushing type mixing room (11),
Described opposite-flushing type mixing room (11) is fixed on the top of described exposure chamber (2), and described opposite-flushing type mixing room (11) is with described The internal connection of exposure chamber (2), described opposite-flushing type mixing room (11) pass through described in liquidate dilution air flow pipeline (12) and described air Compressor (6) connects,
Surrounding sidewall around described exposure chamber (2) is provided with exposure chamber interface (3), the front end of described fixing device for experimental animal (4) It is connected with described exposure chamber (2) by described exposure chamber interface (3),
The bottom of described exposure chamber (2) is connected with described blower fan (14) by pipeline,
Described microcomputer control unit (15) is for regulating and controlling the operational factor of described contamination device.
Powder aerosol dynamic formula per os nasal inhalation contamination device the most according to claim 1, it is characterised in that described contamination Device also includes main cabinet (1), exhaust purifier (13), parameter display unit (16), described main cabinet (1) have base plate, in Layer dividing plate, top board, four column, described air compressor (6) is placed in described main cabinet (1) outward, described powder bubbler (7) with Described rapping apparatus (9) is individually fixed in inside and outside the top of described main cabinet (1);Described exposure chamber (2) is fixed on institute State on the middle level dividing plate of main cabinet (1);Described exhaust purifier (13), described microcomputer control unit (15) and described parameter show Unit (16) is fixed on the crossbeam under the dividing plate of described middle level, and described blower fan (14) is fixed on the base plate of described main cabinet (1), Four column bottom assembling universal wheels of described main cabinet (1), described exhaust purifier (13) is by pipeline and described exposure chamber (2) bottom connects, and described parameter display unit (16) is for showing running status and the parameter of described contamination device.
Powder aerosol dynamic formula per os nasal inhalation contamination device the most according to claim 1, it is characterised in that described exposure Room (2) is the barrel-shaped structure of big volume, major diameter, and lower end connects has taper dust collection, exposure chamber interface (3) to take mistake Position layout, described exposure chamber interface (3) is furnished with blind plate, can be with occluding member interface.
Powder aerosol dynamic formula per os nasal inhalation contamination device the most according to claim 1, it is characterised in that described experiment Animal holder (4) includes movable carriage (17), elastic reducing-fixing band (18), animal accommodation chamber (19), sideboard (20), excrement Just urine collector (21), described animal accommodation chamber (19) makes of transparent organic glass, and its front end is to fit mutually with animal head The tapered conical bucket answered;The main part of described animal accommodation chamber (19) is barrel-shaped cylinder, and difference is all arranged at its top and bottom The open slot of width, open top groove is used for the movement of described sideboard (20) and fixes, and the open slot of bottom is easy to animal The feces urine of excretion enters the described feces urine collector (21) being connected with described animal accommodation chamber (19), and described animal is held Receiving the bottom in cabin (19) is equipped with the latch (22) supporting with described feces urine collector (21) upper groove, by described groove with Described latch (22) coordinates, and facilitates installation and the disassembly, cleaning of described feces urine collector (21);Described sideboard (20) By can the nut of degree of tightness and there is certain thickness circular baffle plate form, have and animal buttocks phase inside the circular baffle plate of its configuration The curved surface that adapts to and animal tail can be allowed through the circular hole (23) of described sideboard (20);
Described contamination device also includes that the first support (5), described movable carriage (17) are placed in the corresponding of described first support (5) Position, the main body of described fixing device for experimental animal (4) is placed in on mounted described movable carriage (17), with described can Described fixing device for experimental animal (4) is fixed by the described elastic reducing-fixing band (18) of the upper configuration of movable support bracket (17).
Powder aerosol dynamic formula per os nasal inhalation contamination device the most according to claim 4, it is characterised in that described first Support (5) is followed successively by the base by stainless steel substrates material, lower floor, middle level and upper strata from top to bottom, passes through threaded rod between each layer Fixing with nut, every layer height adapts with the height of exposure chamber interface (3).
Powder aerosol dynamic formula per os nasal inhalation contamination device the most according to claim 1, it is characterised in that described powder Bubbler (7) includes electromagnetic valve (28), aerosol apparatus (29), medicine bottle (30), and described diffusive gas flow pipeline (8) passes described electromagnetic valve (28) it is connected with described aerosol apparatus (29);Described medicine bottle (30) is fixed on described aerosol apparatus (29) by screw thread and sealing gasket; Described aerosol apparatus (29) is connected with described opposite-flushing type mixing room (11) by described Powder aerosol sample channel (10), will be certain The Powder aerosol of concentration sends into described opposite-flushing type mixing room (11);Described microcomputer control unit (15) by data wire (31) with Described electromagnetic valve (28) connects.
Powder aerosol dynamic formula per os nasal inhalation contamination device the most according to claim 6, it is characterised in that described spraying Device (29) includes inner sleeve (32), sheath trachea (33), and described aerosol apparatus (29) uses double gas circuit structure, and compressed air is from described expansion Dissipating after airflow line (8) enters described aerosol apparatus (29) and be divided into two-way, a road opens below into described medicine bottle (30) bottom, by powdery Medicine (34) blows afloat, and sprays outward from described inner sleeve (32);Another road air-flow is walked around, described from sheath trachea (33) described in top Inner sleeve (32) outside forms parcel sheath gas (35).The powdered drug composition that described sheath gas (35) and described inner sleeve (32) are sent Send outward for mixed airflow (36), travel further into opposite-flushing type mixing room (11).
Powder aerosol dynamic formula per os nasal inhalation contamination device the most according to claim 6, it is characterised in that described rapping Device (9) includes electric magnet (24), cover plate (25), back-moving spring (26), the second support (27), described cover plate (25) the most whole dye The top board of poison cabinet, described electric magnet (24) is fixed on described cover plate (25);Described second support (27) is by the four of its outfit Root threaded rod is fixed on described cover plate (25), and the vibrating shaft on described electric magnet (24) is through described cover plate (25) and described the The circular hole at two supports (27) center is firm with described aerosol apparatus (29) to be connected;It is installed with in the middle of described back-moving spring (26) and is threaded Stainless steel shaft, be connected through the circular hole on described second support (27) and described aerosol apparatus (29) are firm.
Powder aerosol dynamic formula per os nasal inhalation contamination device the most according to claim 1, it is characterised in that described in liquidate Formula mixing room (11) has mixing chamber (37), and described mixing chamber (37) communicates with described exposure chamber (2), and described dust aerosol enters The mouth of pipe of sample pipeline (10) and described dilution air flow pipeline (12) mouth of pipe that liquidates are positioned at the middle of described mixing chamber (37), and on The most relatively, internal diameter is in the same size.
10. the control method of a Powder aerosol dynamic formula per os nasal inhalation contamination device, it is characterised in that
Step 1, opening the main power being positioned at microcomputer control unit (15) place, now microcomputer control unit (15), parameter display is single Unit (16) and blower fan (14) are in energising operating condition, the program of microcomputer control unit (15) is set to " standby " pattern, connects The parameter according to display, set the compressor flow of requirement of experiment;Open power supply and the air delivery valve thereof of air compressor (6), and Output pressure is set.
Step 2, under equipment is in " standby " mode state, take off the dress sample bottle being positioned on powder bubbler (7), by appropriate powder After powder sample loads dress sample bottle, then install back on powder bubbler (7);Select at microcomputer control unit (15) place to run Injection procedure after, according to the character of given the test agent powder choose whether run rapping apparatus (9);Now, contamination equipment starts The parameter corresponding according to target exposure concentration is run.
Run " cleaning " program of microcomputer control unit (15) before step 3, shutdown, after treating that this program is run, close air Compressor (6) and air delivery valve thereof, finally close main power.
CN201610541458.7A 2016-07-11 2016-07-11 A kind of oral nasal inhalation contamination device of Powder aerosol dynamic formula Active CN106175975B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201610541458.7A CN106175975B (en) 2016-07-11 2016-07-11 A kind of oral nasal inhalation contamination device of Powder aerosol dynamic formula

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201610541458.7A CN106175975B (en) 2016-07-11 2016-07-11 A kind of oral nasal inhalation contamination device of Powder aerosol dynamic formula

Publications (2)

Publication Number Publication Date
CN106175975A true CN106175975A (en) 2016-12-07
CN106175975B CN106175975B (en) 2017-07-04

Family

ID=57474101

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201610541458.7A Active CN106175975B (en) 2016-07-11 2016-07-11 A kind of oral nasal inhalation contamination device of Powder aerosol dynamic formula

Country Status (1)

Country Link
CN (1) CN106175975B (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109512541A (en) * 2017-09-19 2019-03-26 中国人民解放军军事科学院军事医学研究院微生物流行病研究所 Medium and small animal organism aerosol mouth and nose exposure system
CN110251266A (en) * 2019-06-25 2019-09-20 中国人民解放军陆军军医大学 Exposure contamination experiment device is combined in a kind of rat noise and carbon monoxide integration
CN112875047A (en) * 2021-01-12 2021-06-01 辽宁科技学院 Component detection kit applied to chemical drugs
WO2022178752A1 (en) * 2021-02-25 2022-09-01 中国科学院生态环境研究中心 Expiratory metabolism measurement system

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4520808A (en) * 1983-03-10 1985-06-04 Stauffer Chemical Company Inhalation exposure apparatus
CN1817324A (en) * 2006-02-17 2006-08-16 范维林 Dynamic inhalational contamination experimental instrument with solid-phase dust
JP2007232453A (en) * 2006-02-28 2007-09-13 Sumitomo Chemical Co Ltd Inhalation toxicity tester and inhalation toxicity testing method
CN202128563U (en) * 2011-07-06 2012-02-01 天津开发区合普工贸有限公司 Rodent only-nasal type inhalation toxicity exposure test device
CN203029422U (en) * 2012-12-20 2013-07-03 中国人民解放军第三军医大学 Infection concentration tank and rat mouth-nose infection concentration tank
CN203370537U (en) * 2013-07-23 2014-01-01 公安部天津消防研究所 Ultrafine powder body aerosol continuous generation device
CN104367398A (en) * 2013-08-13 2015-02-25 北京慧荣和科技有限公司 Whole body exposure system for animals
CN104374928A (en) * 2013-08-13 2015-02-25 北京慧荣和科技有限公司 Multi-concentration animal oral-nasal inhalation dynamic exposure equipment
CN105092786A (en) * 2015-07-23 2015-11-25 上海化工研究院 Oppositely-impacting quantitative atomization drug delivery apparatus

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4520808A (en) * 1983-03-10 1985-06-04 Stauffer Chemical Company Inhalation exposure apparatus
CN1817324A (en) * 2006-02-17 2006-08-16 范维林 Dynamic inhalational contamination experimental instrument with solid-phase dust
JP2007232453A (en) * 2006-02-28 2007-09-13 Sumitomo Chemical Co Ltd Inhalation toxicity tester and inhalation toxicity testing method
CN202128563U (en) * 2011-07-06 2012-02-01 天津开发区合普工贸有限公司 Rodent only-nasal type inhalation toxicity exposure test device
CN203029422U (en) * 2012-12-20 2013-07-03 中国人民解放军第三军医大学 Infection concentration tank and rat mouth-nose infection concentration tank
CN203370537U (en) * 2013-07-23 2014-01-01 公安部天津消防研究所 Ultrafine powder body aerosol continuous generation device
CN104367398A (en) * 2013-08-13 2015-02-25 北京慧荣和科技有限公司 Whole body exposure system for animals
CN104374928A (en) * 2013-08-13 2015-02-25 北京慧荣和科技有限公司 Multi-concentration animal oral-nasal inhalation dynamic exposure equipment
CN105092786A (en) * 2015-07-23 2015-11-25 上海化工研究院 Oppositely-impacting quantitative atomization drug delivery apparatus

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109512541A (en) * 2017-09-19 2019-03-26 中国人民解放军军事科学院军事医学研究院微生物流行病研究所 Medium and small animal organism aerosol mouth and nose exposure system
CN110251266A (en) * 2019-06-25 2019-09-20 中国人民解放军陆军军医大学 Exposure contamination experiment device is combined in a kind of rat noise and carbon monoxide integration
CN112875047A (en) * 2021-01-12 2021-06-01 辽宁科技学院 Component detection kit applied to chemical drugs
WO2022178752A1 (en) * 2021-02-25 2022-09-01 中国科学院生态环境研究中心 Expiratory metabolism measurement system

Also Published As

Publication number Publication date
CN106175975B (en) 2017-07-04

Similar Documents

Publication Publication Date Title
CN106175975B (en) A kind of oral nasal inhalation contamination device of Powder aerosol dynamic formula
KR102001770B1 (en) Air quality environment simulator using fine dust generation
CN211793596U (en) Laboratory is with mouse particulate matter expose cabin device
CN102389339A (en) Only-nose inhaling poison exposure experimental equipment for rodent
Gardner et al. Toxicology of the Lung
CN108872033A (en) The heterogeneous reaction activity measurement device and method of gaseous pollutant in atmospheric environment
Chen et al. Inhalation toxicology methods: the generation and characterization of exposure atmospheres and inhalational exposures
CN108786938A (en) Haze particle forms analog meter
CN105732145A (en) Film mulching aerobic composting reactor test apparatus
CN202128563U (en) Rodent only-nasal type inhalation toxicity exposure test device
Cho et al. On-site application of air cleaner emitting plasma ion to reduce airborne contaminants in pig building
CN210737716U (en) Air supply and exhaust deodorizing system for toilet
CN108240914A (en) Toy flue gas sucks microenvironment preparation system
CN105944632B (en) A kind of Powder aerosol generator for preventing lazy flow medicine from luming
CN205598957U (en) A VOC collecting and processing system for producing in line space
CN104374928A (en) Multi-concentration animal oral-nasal inhalation dynamic exposure equipment
EP3545302B1 (en) Flatbed air-liquid interface exposure module and methods
CN1036267A (en) Autocontrol continuous experimental system for simulating toxicant environment
CN205925433U (en) Air treatment manages and is used for air treatment equipment system of production line
CN208612869U (en) A kind of cabinet body plastic-spraying recyclable device
CN111617614A (en) Harmful gas monitoring and purifying device
CN106969952A (en) One kind breathing digestion and metabolism harvester
CN209679814U (en) A kind of emission-control equipment for rubber refining
CN207468652U (en) A kind of constant-temperature shaking incubator
CN208574471U (en) A kind of marsh gas treatment device for digester overflow ditch

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
GR01 Patent grant
GR01 Patent grant