CN1304844C

CN1304844C - Portable blood sugar meter with blood sugar concentration trend curve display

Info

Publication number: CN1304844C
Application number: CNB2004100892950A
Authority: CN
Inventors: 袁景淇; 王坤; 唐日泉
Original assignee: Shanghai Jiaotong University
Current assignee: Shanghai Jiaotong University
Priority date: 2004-12-09
Filing date: 2004-12-09
Publication date: 2007-03-14
Anticipated expiration: 2024-12-09
Also published as: CN1616966A

Abstract

The present invention relates to a portable blood sugar meter with the trend curve display of blood sugar concentrations, which belongs to the field of medical appliances. A port of a reaction test signal is connected with an operational amplifier and an analog/digital converter; the analog/digital converter is connected with a monolithic computer connected with a liquid crystal display; a memory is connected with the monolithic computer; a clock manager is connected with the monolithic computer; the output VBAT of a voltage monitor is connected with an I/O port RB1 of the monolithic computer; an output pin of a voltage stabilizer is connected with a Vref pin of the analog/digital converter, the voltage monitor and the port of a reaction test signal; the output of a key module is connected with the I/O port of the monolithic computer; a power supply manager is used for supplying a power supply, wherein one path is connected with the monolithic computer, the memory, the clock manager, a dot matrix type liquid crystal display and the analog/digital converter, and the other path is connected with the operational amplifier, the voltage stabilizer and the voltage monitor. The present invention has the advantages of high performance cost rate, simple operation and convenient calibration, and quickly and accurately finishes the collection of output signals for detecting elements of blood sugar and data processing.

Description

The portable glucose meter that band blood sugar concentration trend curve shows

Technical field

The present invention relates to a kind of blood glucose meter, particularly a kind of portable glucose meter with the demonstration of blood sugar concentration trend curve belongs to medical instruments field.

Background technology

Traditional blood-glucose content detection is finished on large-scale Biochemical Analyzer, and sense cycle is grown, the need blood volume is big, cost is high, complicated operation, is unfavorable for patient's self-monitoring.Portable glucose meter can overcome above-mentioned defective, finishes the fast and convenient detection of blood sugar concentration, realize patient's blood sugar self-monitoring, and blood using amount is few.

Through the literature search of prior art is found that the Sun Jianzai of HUST " instrumental technique and sensor " writes articles " development of portable intelligent blood glucose monitoring system " on (6,17-20,1998), this article system introduction a kind of portable blood sugar tester.This tester is a core with the 89C51 singlechip chip, comprises parts such as LCD, V/F converter, constant potential metering circuit, multicircuit switch, temperature and resistance, measuring resistance, supply voltage monitoring and battery.This article in view of the temperature sensitivity of glucose oxidase, has carried out temperature compensation to test result with the glucose content in the glucose enzyme electrode measurement blood, to improve measuring accuracy; In addition, come the bucking-out system measuring error by self-correcting.Self-correcting is by multiway analog switch sequential carrying out between enzyme electrode, thermistor, 10K Ω measuring resistance and the zero load of measuring socket, because the complicacy of calibration circuit, the hardware cost of whole instrument is higher.On the other hand, the leakage current of multiway analog switch and conducting resistance then can be brought extra measuring error, on the complete machine performance, there are deficiencies such as function singleness, cost performance be low in the portable blood sugar tester of document introduction, and lack continuous historical test data and work as Pretesting access, reproduction capability constantly, can not realize monitored for prolonged periods of time, tracking and the contrast of user, can not realize that especially the trend curve of historical blood sugar concentration shows blood sugar concentration.

Summary of the invention

The objective of the invention is to overcome deficiency of the prior art, a kind of portable glucose meter with the demonstration of blood sugar concentration trend curve is provided, make its have the cost performance height, simple to operate, the calibration have a few easily, can finish output signal collection of blood sugar test element and data processing quickly and accurately, history data store and back track function are provided, and have historical data is shown in the function of self LCDs according to the test duration order with the form of trend curve, make the user be able to that blood sugar concentration is carried out Continuous Tracking and monitor.

The present invention is achieved by the following technical solutions, the present invention includes: one-chip computer, storer, timer manager, LCD, analog to digital converter, operational amplifier, the DC-DC level converter, voltage stabilizer, power supervisor, voltage monitor, reaction test signal port and key-press module, wherein, the reaction test signal port links to each other with analog to digital converter through operational amplifier, three I/O pins of analog to digital converter, be CLK, Dout and CS respectively with one-chip computer in I/O mouth RC3/SCK/SCL, RC4/SDI/SDA links to each other with RB2, five I/O pins of LCD, be CS, D/C, SDO, RST and SCK respectively with one-chip computer in I/O mouth RC7, RC6, RC5, RC2 links to each other with RC3/SCK/SCL, the clock signal pin RC3/SCK/SCL of SPI module in LCD and the analog to digital converter time-sharing multiplex single-chip microcomputer wherein, three I/O pins of storer, be WP, SCL and SDA respectively with one-chip computer in I/O mouth RC0, RB3 links to each other with RB4, three I/O pins of timer manager, be SCLK, I/O and RESET respectively with one-chip computer in I/O mouth RA0, RA1 links to each other with RA2, the output VBAT of voltage monitor links to each other with I/O mouth RB1 in the one-chip computer, the Vref pin of the output pin connection mode number converter of voltage stabilizer, voltage monitor and reaction test signal port, the output of key-press module links to each other with I/O mouth RB5 in the one-chip computer, power supervisor provides the two-way voltage swing different power supplys, wherein one the tunnel and one-chip computer, storer, timer manager, LCD and analog to digital converter link to each other, and other one the tunnel and operational amplifier, voltage stabilizer, voltage monitor links to each other.

The pin PS0 of LCD and PS1 link high level and ground by 10K resistance respectively, sampling resistor in the reaction test signal port is that grade of errors is 1% 60K precision resistance, voltage stabilizer is respectively 3K fixed resistance, 2.2K adjustable resistance and 33K fixed resistance for the resistance in the series loop that the Vref pin of analog to digital converter provides reference voltage, and voltage stabilizer is respectively 10K fixed resistance, 2.2K adjustable resistance and 100 Ω fixed resistances for the resistance in the series loop that the reaction test signal port provides response voltage.

Described one-chip computer CPU adopts the PIC16F873A cake core; LCD adopts the dot matrix display module; Storer E2PROM adopts the AT24C32 cake core; Timer manager adopts the HT1380 cake core.

The present invention has substantive distinguishing features and marked improvement, and the present invention has mainly adopted four technical measures: 1) realizing under the prerequisite of required function, adopting that function is strong, compact conformation and cheap components and parts.2) by increasing the data base administration that the hardware capability module has realized the historical test data record of blood sugar concentration, outstanding feature is to have historical data curve display function and Chinese and English operation interface.3) design the lowering apparatus power consumption by optimizing power supply.4) make full use of software function and simplify hardware circuit.Adopt that the portable glucose meter of above-mentioned technology has multiple functional, compact conformation, is convenient for carrying, advantages of simple operation.

Description of drawings

Fig. 1 structural representation of the present invention

Embodiment

As shown in Figure 1, the present invention includes: one-chip computer 1, storer 2, timer manager 3, LCD 4, analog to digital converter 5, operational amplifier 6, voltage stabilizer 7, power supervisor 8, voltage monitor 9, reaction test signal port 10 and key-press module 11.Wherein, reaction test signal port 10 links to each other with analog to digital converter 5 through operational amplifier 6, three I/O pins of analog to digital converter 5, be CLK, Dout and CS respectively with one-chip computer 1 in I/O mouth RC3/SCK/SCL, RC4/SDI/SDA links to each other with RB2, five I/O pins of LCD 4, be CS, D/C, SDO, RST and SCK respectively with one-chip computer 1 in I/O mouth RC7, RC6, RC5, RC2 links to each other with RC3/SCK/SCL, the clock signal pin RC3/SCK/SCL of SPI module in LCD 4 and the analog to digital converter 5 time-sharing multiplex single-chip microcomputers wherein, three I/O pins of storer 2, be WP, SCL and SDA respectively with one-chip computer 1 in I/O mouth RC0, RB3 links to each other with RB4, three I/O pins of timer manager 3, be SCLK, I/O and RESET respectively with one-chip computer 1 in I/O mouth RA0, RA1 links to each other with RA2, the output VBAT of voltage monitor 9 links to each other with I/O mouth RB1 in the one-chip computer 1, the Vref pin of the output pin connection mode number converter 5 of voltage stabilizer 7, voltage monitor 9 and reaction test signal port 10, the output of key-press module 11 links to each other with I/O mouth RB5 in the one-chip computer 1, power supervisor 8 provides the two-way voltage swing different power supplys, wherein one the tunnel with one-chip computer 1, storer 2, timer manager 3, LCD 4 and analog to digital converter 5 links to each other, other one the tunnel with operational amplifier 6, voltage stabilizer 7, voltage monitor 9 links to each other.

The pin PS0 of LCD 4 and PS1 link high level and ground by 10K resistance respectively, sampling resistor in the reaction test signal port 10 is that grade of errors is 1% 60K precision resistance, voltage stabilizer 7 is respectively 3K fixed resistance, 2.2K adjustable resistance and 33K fixed resistance for the resistance in the series loop that the Vref pin of analog to digital converter 5 provides reference voltage, and voltage stabilizer 7 is respectively 10K fixed resistance, 2.2K adjustable resistance and 100 Ω fixed resistances for the resistance in the series loop that reaction test signal port 10 provides response voltage.

Described one-chip computer 1CPU adopts the PIC16F873A cake core; LCD 4 adopts the dot matrix display module, can show Chinese and English operation interface, test result and historical data trend curve figure; Adopt the AT24C32 cake core as the E2PROM data-carrier store, can realize the simple data library management of historical test record; Adopt the HT1380 cake core as timer manager, can real time record measure the moment of generation at every turn.

Wherein, at first by the start of key-press module 11 control instruments, start back instrument is in the detection waiting status, and apply a certain size constant operating voltage at the enzyme electrode two ends by reaction test signal port 10, reaction beginning back is imported the kinetic current signal Ix of enzyme electrode by reaction test signal port 10, after operational amplifier 6 amplifies, send into analog to digital converter 5 and be converted to digital quantity, read transformation result by one-chip computer 1 again and finish the calculating of concentration of glucose, by LCD 4 test result is shown at last.In order to save the instrument volume, adopted that number of pins is few, the serial a/d based on spi bus, LCD and based on storer, the timer manager of I2C bus.One-chip computer adopts PIC16F873A.

As shown in Figure 1, circuit circuit diagram of the present invention has also additionally increased by two independently functional modules except that comprising the basic test circuit, i.e. storer 2 and timer manager 3.The introducing of these two functional modules is preserved the blood glucose test result of (as three months) in a period of time and test as historical record constantly one by one, the user only need can conveniently inquire about former test result by key-press module 11 during operation, or shows the historical data trend map by key-press module 11 on liquid crystal display.The present invention has also adopted high-resolution dot matrix lcd 4, has friendly Chinese and English operation interface simultaneously, has made things convenient for the user of each colony.

In order to reduce power consumption, the present invention has designed two voltage out-put supply managers 8, wherein one tunnel output 3.3V voltage is given one-chip computer 1, storer 2, timer manager 3, LCD 4 and analog to digital converter 5, other one tunnel output 5V voltage is given operational amplifier 6, voltage stabilizer 7/ voltage monitor 9, reaches the purpose that reduces power consumption by the operating voltage that reduces chips more than half.

The present invention makes full use of software function, has reduced hardware cost.For example, calibration function is exactly to be realized by software, has promptly adopted test result offset correction method to come the calibration testing result in program.

Claims

1, a kind of portable glucose meter with the demonstration of blood sugar concentration trend curve, comprise: one-chip computer (1), LCD (4), analog to digital converter (5), operational amplifier (6), voltage stabilizer (7), voltage monitor (9), reaction test signal port (10) and key-press module (11), it is characterized in that, also comprise: storer (2), timer manager (3), power supervisor (8), reaction test signal port (10) links to each other with analog to digital converter (5) through operational amplifier (6), three I/O pins of analog to digital converter (5), be CLK, Dout and CS respectively with one-chip computer (1) in I/O mouth RC3/SCK/SCL, RC4/SDI/SDA links to each other with RB2, five I/O pins of LCD (4), be CS, D/C, SDO, RST and SCK respectively with one-chip computer (1) in I/O mouth RC7, RC6, RC5, RC2 links to each other with RC3/SCK/SCL, the clock signal pin RC3/SCK/SCL of SPI module in LCD (4) and analog to digital converter (5) the time-sharing multiplex single-chip microcomputer wherein, three I/O pins of storer (2), be WP, SCL and SDA respectively with one-chip computer (1) in I/O mouth RC0, RB3 links to each other with RB4, three I/O pins of timer manager (3), be SCLK, I/O and RESET respectively with one-chip computer (1) in I/O mouth RA0, RA1 links to each other with RA2, the output VBAT of voltage monitor (9) links to each other with I/O mouth RB1 in the one-chip computer (1), the Vref pin of the output pin connection mode number converter (5) of voltage stabilizer (7), voltage monitor (9) and reaction test signal port (10), the output of key-press module (11) links to each other with I/O mouth RB5 in the one-chip computer (1), power supervisor (8) provides the two-way power supply, wherein one the tunnel with one-chip computer (1), storer (2), timer manager (3), LCD (4) and analog to digital converter (5) link to each other, other one the tunnel with operational amplifier (6), voltage stabilizer (7), voltage monitor (9) links to each other.

2, the portable glucose meter that band blood sugar concentration trend curve according to claim 1 shows, it is characterized in that, the pin PS0 of LCD (4) and PS1 link high level and ground by 10K resistance respectively, sampling resistor in the reaction test signal port (10) is that grade of errors is 1% 60K precision resistance, voltage stabilizer (7) is respectively the 3K fixed resistance for the resistance in the series loop that the Vref pin of analog to digital converter (5) provides reference voltage, 2.2K adjustable resistance and 33K fixed resistance, voltage stabilizer (7) are respectively the 10K fixed resistance for the resistance in the series loop that reaction test signal port (10) provides response voltage, 2.2K adjustable resistance and 100 Ω fixed resistances.

3, according to the portable glucose meter of claim 1 or 2 described band blood sugar concentration trend curves demonstrations, it is characterized in that LCD (4) adopts the dot matrix display module.

4, the portable glucose meter of band blood sugar concentration trend curve demonstration according to claim 1 is characterized in that, one-chip computer (1) CPU adopts the PIC16F873A cake core.

5, the portable glucose meter of band blood sugar concentration trend curve demonstration according to claim 1 is characterized in that, adopts the AT24C32 cake core as E ²PROM data-carrier store (2).

6, the portable glucose meter of band blood sugar concentration trend curve demonstration according to claim 1 is characterized in that, timer manager (3) adopts the HT1380 cake core.