CN1399531A - 左心房附件口的阻挡装置 - Google Patents

左心房附件口的阻挡装置 Download PDF

Info

Publication number
CN1399531A
CN1399531A CN00816176A CN00816176A CN1399531A CN 1399531 A CN1399531 A CN 1399531A CN 00816176 A CN00816176 A CN 00816176A CN 00816176 A CN00816176 A CN 00816176A CN 1399531 A CN1399531 A CN 1399531A
Authority
CN
China
Prior art keywords
barrier film
atrial appendage
mouth
adnexa
fixed
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN00816176A
Other languages
English (en)
Inventor
罗伯特·A·范塔塞尔
罗伯特·G·豪泽
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Atritech Inc
Original Assignee
Atritech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Atritech Inc filed Critical Atritech Inc
Publication of CN1399531A publication Critical patent/CN1399531A/zh
Pending legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/0057—Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
    • A61B17/12099—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder
    • A61B17/12122—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder within the heart
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
    • A61B17/12131—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
    • A61B17/12131—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device
    • A61B17/12136—Balloons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
    • A61B17/12131—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device
    • A61B17/12159—Solid plugs; being solid before insertion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
    • A61B17/12131—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device
    • A61B17/12168—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device having a mesh structure
    • A61B17/12172—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device having a mesh structure having a pre-set deployed three-dimensional shape
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
    • A61B17/12131—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device
    • A61B17/12181—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device formed by fluidized, gelatinous or cellular remodelable materials, e.g. embolic liquids, foams or extracellular matrices
    • A61B17/12186—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device formed by fluidized, gelatinous or cellular remodelable materials, e.g. embolic liquids, foams or extracellular matrices liquid materials adapted to be injected
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/00234—Surgical instruments, devices or methods, e.g. tourniquets for minimally invasive surgery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B2017/00017—Electrical control of surgical instruments
    • A61B2017/00022—Sensing or detecting at the treatment site
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B2017/00017—Electrical control of surgical instruments
    • A61B2017/00022—Sensing or detecting at the treatment site
    • A61B2017/00039—Electric or electromagnetic phenomena other than conductivity, e.g. capacity, inductivity, Hall effect
    • A61B2017/00044—Sensing electrocardiography, i.e. ECG
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/00234—Surgical instruments, devices or methods, e.g. tourniquets for minimally invasive surgery
    • A61B2017/00238—Type of minimally invasive operation
    • A61B2017/00243—Type of minimally invasive operation cardiac
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/0057—Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect
    • A61B2017/00641—Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect for closing fistulae, e.g. anorectal fistulae
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
    • A61B2017/1205—Introduction devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/06—Measuring instruments not otherwise provided for
    • A61B2090/064—Measuring instruments not otherwise provided for for measuring force, pressure or mechanical tension
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/06—Measuring instruments not otherwise provided for
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/01—Filters implantable into blood vessels
    • A61F2002/018—Filters implantable into blood vessels made from tubes or sheets of material, e.g. by etching or laser-cutting
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2230/0002—Two-dimensional shapes, e.g. cross-sections
    • A61F2230/0004—Rounded shapes, e.g. with rounded corners
    • A61F2230/0006—Rounded shapes, e.g. with rounded corners circular
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2230/0063—Three-dimensional shapes
    • A61F2230/0069—Three-dimensional shapes cylindrical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2230/0063—Three-dimensional shapes
    • A61F2230/0073—Quadric-shaped
    • A61F2230/008—Quadric-shaped paraboloidal

Abstract

本发明涉及一种用于心房附件口、阻挡血液进入心房附件而可能在其中形成血块的隔膜。隔膜还防止心房附件中的血块离开并进入血流而可能导致血管阻塞和心脏病发作。隔膜经由皮肤安装在患有心房纤维性颤动以及心房附件中可能形成血栓的其它心脏疾患的患者体内。本发明涉及各种使隔膜固定就位的装置。隔膜可以固定在心房附件口上，或者填充心房附件内部。使隔膜固定在心房附件口上的装置包括插脚、移植片固定物、具有系绳或弹簧的锚固件、具有系绳或弹簧的盘形件、伞形件、填充心房附件的螺旋弹簧、以及粘合剂。隔膜固定就位后，一种填料物质可以注入到心房附件内以缩小其空间，有助于隔膜密封在附件口上或使心房附件中的血液凝结。隔膜可以具有抗血凝剂以防血栓形成。隔膜可以具有气孔，使内皮细胞覆盖隔膜而成为一种“活”隔膜壁，以防血栓形成。隔膜可以具有使隔膜对中定位在附件口上的装置。传感器可以固定在隔膜上，以提供关于患者的信息。

Description

左心房附件口的阻挡装置
技术领域
本发明涉及一种应用于心房附件口的隔膜或插塞装置，这种装置用于防止在一个心房和相连的心房附件之间的血液流动和生理连接，以隔开一个心房附件，防止血栓离开该心房附件。
背景技术
有许多心脏病(例如冠状动脉病、二尖瓣病)对心脏具有各种各样的有害作用。某些心脏病例如二尖瓣病的一个有害作用是心房纤维性颤动。心房纤维性颤动可以在左心房附件中造成淤血。淤血也可以是自发的。当血液淤积在心房附件中时，血块可以在其中形成、积累、增大并从心房附件散布到心房中。这些血块如果从心房附件转移，在血流中自由流动，从末端进入动脉系统，则可以进入体循环或肺循环，导致严重疾患。当一个从一个心房附件延伸到一个心房的血块断开并进入血液供给系统时，也会发生类似的疾患。由于来自左心房和心室的血液供给心脏和脑，因此，来自心房附件的血块可以阻止血液流入而导致心脏病发作或其它器官局部缺血。因此，必须研究出一种装置防止血块在心房附件中形成，防止形成后的血块离开心房附件进入患者的心脏、肺、脑或其它循环而导致心脏病发作或其它器官局部缺血。
专利5865791涉及缩小血液郁滞区域并最终减少在这些区域尤其是在患有心房纤维性颤动的患者的心房附件中形成血栓。更具体地说，该发明涉及沿着一个防止随后形成血栓的方向固定心房附件的方法和装置。该发明提出从心房摘除附件，其方法是，拉住心房附件，围绕它放置一个环形件，形成一堆心房附件，然后从心脏的其余部分上将其切除。
专利5306234涉及一种通过外科手术封闭心房和心房附件之间的通道或者切除心房附件的方法。
其它治疗方法包括通过外科手术摘除心房附件，以防血液郁滞在心房附件中。
发明内容
本发明提出一种隔膜或插塞装置，这种装置防止血液进入心房附件形成血块以及防止在心房附件中形成的血块离开心房附件而导致心脏病发作或其它栓塞疾患。隔膜覆盖心房附件口，使之与心房有效隔离。隔膜可以大于心房附件口，在大于附件口的一个区域上延伸。隔膜由一个导管经由皮肤输送到心房附件口，然后膨胀以覆盖附件口，有一个装置使隔膜固定在附件口上。隔膜本身可以是气孔式或非气孔式的。如果是一种气孔隔膜，则细胞可以通过，因此成为一个“活”装置，可以形成一种内皮/心内膜衬料使之再成为一个不形成血栓的表面。有许多固定隔膜使之覆盖附件口的装置。隔膜固定装置具有一个使隔膜自对中定位在附件口上的装置。隔膜可以粘接，或者具有通过附件口延伸到心房附件中的一个移植片固定物(stent)或插脚。另一方面，心房附件壁上的一个锚固件可以系到隔膜上，使隔膜固定就位。弹簧也可以延伸在锚固件和隔膜之间，使隔膜固定到附件口上。隔膜也可以与一根系绳、弹性系绳或弹簧相连接并通过心房附件壁加以布置，使隔膜固定到附件口上，而且可以拉住心房附件，使其空间缩小或消除，密封和隔离其中的血块。凝血酶、活性血纤维蛋白原或其它生物填料可以在心房附件被密封后置于心房附件中，其特殊目的是为了使血液在心房附件中凝结，此外还防止血块离开心房附件。
装置的一部分可以包括一个去除已形成血块的吸取装置。隔膜的布置可能需要封闭由于布置这种心房闭合装置而造成的心房中隔缺陷。
另一方面，隔膜可以由一个填充心房附件空间的盘簧固定就位。隔膜也可以填充心房附件本身，以防止血液进入，或防止血块离开。
隔膜本身可以是气孔式或非气孔式的。如果是一种气孔隔膜，则细胞可以渗入，因此成为一个“活”装置，可以形成一种内皮/心内膜衬料使之再成为一个不形成血栓的表面。因此，可以形成一种内皮，随着时间的推移，具有高度生物兼容性。隔膜布置后可以立即涂覆肝素，以防在隔膜表面形成血栓，直至细胞渗入和/或形成一层内皮覆盖层。
装置植入心房附件时，也可以对心脏进行电监测。两个或多个电触点分开布置在装置上，并且同信号调节电路相连接，测定心脏特征例如心房或心室的节律。装置上的另一个传感器可以测定心房、心房附件或心室的压力以及通过开放的二尖瓣或三尖瓣的舒张压(左或右)。使用一个适当的遥测系统在患者体外无损害地遥测该重要的血压电信息。装置上可以配置存储器，记录信息，以便以后通过无损害遥测技术进行收集。
该装置也可以用于封闭体内其它部位例如结肠系统或者支气管肺系统的瘘或联系。该装置的另一个用途是将隔膜固定到左心室的假动脉瘤上使之密封和强化。凡是隔膜固定到瘘或假动脉瘤上，都采用相同的原理，隔膜由弹簧或插脚机构加以固定就位。
装置也可以用于使用化学制剂烧蚀心房附件中的心肌组织，以便限制或消除心房纤维性颤动的电传播。
本发明旨在缩小心房附件的空间，缩小血淤形成的潜在区域，从而缩小有疾患的心房的有效空间。
本发明旨在测定心脏的血压(或血流量)或者电信号，在体外对它们进行遥测，以供诊断或监测。
本发明旨在封闭体内其它部位例如结肠系统或者支气管肺系统的瘘或联系。
本发明旨在将隔膜置于一个假动脉瘤上使之强化，以避免外科手术。
本发明旨在缩小心房附件中血液郁滞区域，从而减小心房中形成血栓的可能性。
本发明旨在防止血块在心房附件中形成。
本发明旨在用一个不形成血栓的生物兼容表面置于心房附件口上，该表面防止血块形成。
本发明旨在提出一种衬有内皮或内心膜细胞的气孔隔膜表面。
本发明旨在使心房附件与心房本身隔离，防止连通而可能转移血栓。
本发明旨在尽量无损害地防止血块在心房附件中形成并离开心房附件。
本发明旨在提出一种置于心房和心房附件之间的过滤器，防止血块在两者之间流动。
本发明旨在用一种材料填充心房附件，防止血块离开心房附件。
本发明旨在通过吸取或其它方法从心房去除血栓。
本发明旨在提出一种使移植有细胞的一个隔膜紧固到心房附件口上，并提出一种包括但不限于内皮化的高度生物兼容表面。
本发明旨在通过将肝素或其它抗血栓形成物质使用到隔膜上或者从隔膜洗脱，防止血栓。
本发明旨在用一种注入到心房附件中的物质密封隔膜。
本发明旨在在隔膜固定就位之后，用一种注入到心房附件中的物质使心房附件中的血液凝结。
本发明旨在将一种物质注入到密封的心房附件中，烧蚀心房附件的心肌细胞，以限制心房纤维性颤动的传播。
本发明旨在确保隔膜对中定位在心房附件口上。
本发明旨在精确地将隔膜置于心房附件口上。
附图说明
参照附图和非限制实施例，本发明的其它目的、优越性和特征将得到更好地理解。
图1是心脏的局部剖面图，示出一个导管采用逆行法从主动脉进入左心房附件。
图2是心脏的局部剖面图，示出一个导管采用穿过中隔法从股静脉或上腔静脉进入左心房附件。
图3是心脏的局部剖面图，示出一个导管从颈静脉或者可选地从股静脉进入右心房附件。
图4是一部分心脏的局部剖面图，示出一个心房及其相连的心房附件。
图5是一部分心脏的局部剖面图，示出一个心房及其相连的心房附件，一个气孔隔膜具有使隔膜固定就位的挠性金属线插脚，插脚具有无损伤球形件，电子元件安装在隔膜上。
图6类似于图5，挠性金属线插脚没有无损伤球形件，因此可以刺穿心房壁，确保隔膜固定在心房附件上，隔膜还配有一个对中定位凸缘。
图7是图5所示一部分心脏的局部剖面图，隔膜和插脚之间具有一个移植片固定物。
图8与图7相同，挠性金属线插脚没有无损伤球形件，因此可以刺穿心房壁，确保隔膜固定在心房附件上。
图9是一部分心脏的局部剖面图，示出一个心房及其相连的心房附件，一个气孔隔膜具有一个大的使隔膜固定就位的可膨胀移植片固定物。
图10是一部分心脏的局部剖面图，示出一个心房及其相连的心房附件，一个锚固件和一根系绳将隔膜固定就位。
图11是一部分心脏的局部剖面图，示出一个心房及其相连的心房附件，一个锚固件和一个弹簧将隔膜固定就位，隔膜上配有一个对中定位凸缘，还配有一个对中定位索。
图12与图11相同，填充心房的弹簧有助于使隔膜固定就位。
图13是一部分心脏的局部剖面图，示出一个心房及其相连的心房附件，隔膜以粘接方式固定就位。
图14是一个输送导管的局部剖面图，导管中装有一个盘形件、一个弹簧和一个隔膜。
图15是从图14所示导管中输出的膨胀后的盘形件、弹簧和隔膜的示意图。
图16是一部分心脏的局部剖面图，示出一个心房及其相连的心房附件，其间具有一个盘形件、一个隔膜和一个弹簧。
图17是一部分心脏的局部剖面图，示出处于压缩位置的一个心房及其相连的心房附件。
图18是一部分心脏的局部剖面图，示出一个心房及其相连的心房附件，其中具有一个盘形件、一个弹簧、一个隔膜以及导管所配有的真空装置。
图19是一部分心脏的局部剖面图，示出一个心房及其相连的心房附件，一种隔膜材料填充心房附件。
图20是一部分心脏的局部剖面图，示出一个心房及其相连的心房附件，并示出一个用于进入心房附件的折叠的伞形件。
图21是一部分心脏的局部剖面图，示出一个心房及其相连的心房附件，伞形件在心房附件中打开，确保伞形件固定在心房附件壁上。
图22是一部分心脏的局部剖面图，示出一个心房及其相连的心房附件，伞形件和隔膜已密封心房附件口。
图23是一部分心脏的局部剖面图，示出一个心房及其相连的心房附件，一个移植片固定物具有一个阻挡心房附件口的隔膜。
图24是一部分心脏的局部剖面图，示出一个心房及其相连的心房附件，由于一个盘形件和弹簧将心房附件挤压在一个隔膜上，因此，心房附件被压缩到最小空间。
具体实施方式
虽然心房纤维性颤动导致左心房淤血，本发明在多数情况下用于左心房附件，但是，本发明也可以用于右心房附件，一般来说，用于体内任何需要阻塞以防血液从那里流通或流出的孔口。
如图4所示，当患者患有心房纤维性颤动时，由于血液流通不畅，在左心房附件13中可能出现淤血而形成一个血栓30。为了防止血栓30在左心房附件13中形成，或者防止在那里形成的血栓离开而进入血流从而可能导致心脏病发作或局部缺血，一个隔膜40置于心房附件13的口20上。隔膜40可以用特氟隆、毛毡、涤纶、硅氧烷聚氨酯、Gortex、金属纤维或生物兼容聚合物制成。
隔膜40可以是一种气孔隔膜。气孔隔膜可以由一种有气孔的生物兼容聚合物所构成，气孔大小为20至100微米。气孔在很少情况下可以大一些或小一些。隔膜也可以是一种允许细胞在内生长并覆盖有内皮细胞的有气孔的金属或细纤维金属网。隔膜可以涂覆有抗血凝剂，或者洗脱抗血凝剂。
气孔隔膜从心脏移植细胞，从而形成壁以堵塞口20，这样，血液不能流入左心房附件13形成血栓30，更为重要的是，形成的血栓30不能离开左心房附件13而导致心脏病发作或局部缺血。
置于口20上的隔膜40应该抗血栓形成。为了使隔膜抗血栓形成，肝素或者其它抗血凝剂或抗血小板剂可以用于隔膜40。
使用气孔隔膜40时，具有在内生长的细胞以内皮细胞覆盖隔膜，内皮细胞具有光滑的细胞壁覆盖隔膜，在隔膜处防止血栓形成。
血液淤积在左心房附件13中时，血栓30(血块)可以在其中累积、增大，并从左心房附件13扩散到左心房11，进入血流，离开心脏，如果驻留在其动脉中，则可以阻挡血液流到心脏、脑、其它器官或周围的血管。
图1和2是一个人体心脏的剖面图，示出左心房附件13中的一个血栓30。图中还示出心房附件口20，一个隔膜40置于该附件口上，以防血栓30离开心房附件13，进入左心房11，从而进入血流，可能导致心脏病发作或局部缺血。隔膜40还防止血液进入左心房附件13，由于血流不畅而在那里淤积成为血栓。
图3是一个人体心脏的剖面图，示出右心房附件23中的一个血栓30。右心房附件23可以如同左心房附件13一样加以处理。
图4是左心房11、附件口20和左心房附件13的剖面图，左心房附件13中具有一个血栓30。
图5示出本发明第一实施例，其中，气孔隔膜40具有挠性插脚50，插脚50可以用一种形状记忆合金例如镍钛金属互化物制成，以保持一种预先处理的形状。插脚50可以是无损伤的，以致于不刺穿左心房附件13。插脚50可以在其端头具有无损伤球形件55，使得插脚50的端头不会刺穿左心房附件13。镍钛金属互化物具有能够在导管中处于紧密构形状态而当从导管松开时则膨胀到预定记忆形状的特性。所选形状可以使插脚50围绕附件口20的唇部弯曲，然后紧靠在左心房附件13的侧面上。这样，隔膜40会安全地阻挡附件口20，以防血液进入，尤其是防止血栓30离开左心房附件13。
隔膜40自对中定位在左心房附件13的口20上，由于插脚50围绕隔膜40布置成一个圆，因此，插脚50在附件口20的唇部或其内紧靠左心房附件13的壁，使隔膜40对中定位在附件口20上。隔膜40也可以通过一个对中定位凸缘65(见图6)进行对中定位，该定位凸缘固定到隔膜40的背面(附件)上，伸进附件口20以进行对中定位。对中定位凸缘65的直径小于隔膜40的直径。对中定位件也可以由一组对中定位锚固件66(见图11)构成，这些锚固件固定到来自对中定位凸缘65或隔膜40的一个弹簧90或一根系绳85上，确保对中定位。
可选的是，隔膜上装的电子元件例如传感器300和芯片310可以用于提供关于血液动压、血流速率、温度、心博率以及心脏电信号的数据。当隔膜置于左心房附件13中时，传感器300可以测定心房或心房附件中的压力。传感器也可以测定通过开放的二尖瓣的心室压力和舒张压。也可以收集其它关于心脏的信息例如加速计的噪音来测定漏出、瓣的效率、患者的活动程度以及其它与噪音有关的数据。传感器300也可以是血氧传感器。芯片310可以采用遥测技术将传感器300收集的由芯片310处理或存储的信息传送到接收装置，协助对患者的治疗。
如图6所示，保护性球形件55从图5所示的挠性插脚50去除，使挠性插脚50刺穿左心房附件13的壁，确保隔膜40固定就位。挠性插脚50可以进入心房附件壁或穿过心房附件壁进行延伸。插脚可以具有倒刺端部51，以防插脚脱离心房附件壁。
隔膜40具有附属的对中定位凸缘65，用于使隔膜对中定位在附件口20上，隔膜40上的指示器320用于插入隔膜时观察其位置。指示器可以用于进行X线或超声波观察。
虽然前面述及可以使用镍钛金属互化物作为一种形状记忆合金插脚材料，但是，可以采用任何类型的记忆合金。这些合金具有温度感应相变特性，当加热到一定的转变温度以上时，会使材料具有最佳构形。其它可以用作插脚的金属包括耐蚀弹簧金属例如埃尔基洛伊耐蚀游丝合金或者弹簧回火钢。
本发明另一个实施例示于图7。该实施例类似于图5所示的实施例。图7所示的实施例具有一个移植片固定物60，该固定物固定在隔膜40上，用于在附件口20中延伸，以确保隔膜40固定在附件口20上。插脚50如同图5所示的那样，紧靠在左心房附件13的内壁上，确保隔膜40覆盖附件口20。移植片固定物60也可以用镍钛金属互化物、埃尔基洛伊耐蚀游丝合金(Elgiloy)或者其它膨胀弹簧材料或轻型膨胀材料。
由于移植片固定物60插入到左心房附件13的口20中，而隔膜40对中定位在所述固定物上，因此，隔膜40可以自对中定位在所述附件口上。而且，插脚50在附件口20的唇部或其内紧靠左心房附件13的壁，使隔膜40对中定位在附件口20上。
在图8中，保护性球形件55从图7所示的挠性插脚50去除，使挠性插脚50刺穿左心房附件13的壁，确保隔膜40固定就位。挠性插脚50可以进入心房附件壁或穿过心房附件壁进行延伸。插脚可以具有倒刺端部51，以防插脚脱离心房附件壁。
在图9所示的实施例中，一个大的移植片固定物70用于既同附件口20的侧面相接合，又紧靠在左心房附件13的内壁上。同样，移植片固定物可以用镍钛金属互化物、埃尔基洛伊耐蚀游丝合金或其它可在导管中输送并膨胀到适当尺寸和形状的材料制成，安全可靠地使隔膜40保持在附件口20上，以防血液进入左心房附件13，并且防止血栓30形成。
图10示出本发明另一个实施例，其中，隔膜40通过一个锚固件80紧固在附件口20上，所述锚固件进入或穿过左心房附件13的壁，通过锚固件的表面区域紧固在那里，使之不脱离左心房附件13的壁，以防在左心房附件13中形成栓塞。一根系绳85固定到锚固件80和隔膜40上，确保隔膜40恰好紧靠在附件口20上。一种物质270例如凝血酶、活性血纤维蛋白原或其它生物填料可以在隔膜40固定就位后通过一个导管注入左心房附件13中，使血液在心房附件中凝结而不能排出。装置输送导管本身可以具有一个进行这种注入的注入口。注入口也可以用于注入造影剂例如心脏回波检查造影剂，这种造影剂可以立即观测到，经分析可确定附件口和装置之间是否密封良好。注入心房附件的物质270也可以是一种使隔膜密封以防从心房附件漏出的密封剂或填料。本发明任何实施例均可使用密封剂材料、填料材料或血凝材料。
在其它实施例中，导管可以注入一种化学烧蚀剂例如乙醇，对密封的心房附件13中的心肌细胞进行烧蚀，从而由于限制或消除心房附件中的电传播而限制心房纤维性颤动。
图11示出本发明另一个实施例，其中，隔膜40除了锚固件80之外还具有一个螺旋弹簧90。螺旋弹簧90可以同系绳85一起使用或分开使用，将隔膜40牵拉在附件口20上。虽然图9已经示出一种螺旋弹簧90，但是，所采用的形状可以是椭圆形、圆柱形、长方形或其它形状，使锚固件80与隔膜40相连接。在图12所示的另一个实施例中，螺旋弹簧90可以填充左心房附件13的空间，确保隔膜40紧固在附件口20上。填充左心房附件13空间的螺旋弹簧90也可以具有一个锚固件80和一根系绳85，使隔膜40紧固在附件口20上。另一方面，如图11所示，可以采用对中定位凸缘65，使隔膜40对中定位在左心房附件13的口20上。可以使用同螺旋弹簧90以及同隔膜40或对中定位凸缘65相连接的对中定位锚固件66，使隔膜40对中定位在附件口20上。
图13示出隔膜40紧固到附件口20上的另一个方法。在该实施例中，隔膜40用一种粘合剂100直接粘合到附件口20上。
图14示出一个输送导管125，导管125内装一个压缩的气孔隔膜40和一个压缩的盘形件130，隔膜40和盘形件130在导管21上由一个螺旋弹簧90加以连接。盘形件130可以由一种挠性金属编织件或一种具有一薄层气孔聚合物内夹层的挠性金属编织件制成。盘形件130也可以是一种聚合物编织件。盘形件130呈挠性，可以压缩或折叠，因此适于装入输送导管125中，并且在从输送导管125中松开后膨胀到所需的形状。同样，隔膜40可以压缩或折叠，适于装入输送导管125中，并且在松开后膨胀到所需的形状。图15示出图14所示的在输送导管125之外处于膨胀构形的气孔隔膜40、盘形件130和弹簧90。
图15示出使气孔隔膜40与盘形件130相连接的弹簧90。在其它实施例中，也可以使用一根弹性系绳或一根在气孔隔膜40上具有齿和一个棘爪以形成一个棘轮机构的系绳，将气孔隔膜40和盘形件130牵拉在一起。
图16示出图15所示的装置应用于具有血栓30的左心房附件13。在装置装上之后，弹簧90将盘形件130拉向气孔隔膜40，压缩左心房附件13，将血栓30阻挡在其中，如图17所示。
图18示出图16和17所示装置的其它实施例，其中，导管21配有一个真空装置140，用于吸出在左心房附件13中发现的血液和血栓30。真空装置140有助于压缩左心房附件13，因此，弹簧90无需如同图16所示的那样大。
图19示出装置的其它实施例，其中，隔膜150插入并填充左心房附件13，使隔膜150紧固在其中。隔膜150可以作为一种压缩材料在一个导管中进行输送并且在心房附件13中膨胀，或者以一种液体方式进行输送，填充心房附件，再用另一种由导管输送的化学制剂进行固化，或者借助于通过导管21中的一根纤维光缆提供的紫外线进行固化，转变成一种隔膜。用一种隔膜材料150填充左心房附件13，血液就不能进入而淤积成为血栓30，也就不会形成血栓30而导致心脏病发作和局部缺血。
图20至22示出本发明另一个实施例，该实施例采用伞的原理使隔膜40紧固到附件口20上。图20示出闭合的伞撑160进入左心房附件13的口20中。隔膜40从伞撑160向后一定距离，在伞柱170上位于齿195分布区的底部。图21示出位于左心房附件13之内的伞撑，伞撑160呈打开状态。伞柱170上的伞开启件175将伞撑推出到伞打开位置。伞开启件175可以被推到打开位置，或者具有一个弹簧机构将伞撑160推到打开位置。伞撑160的端部围绕附件口20同左心房附件壁相接合，以防伞形件脱离左心房附件13。与心房附件壁相接合的伞撑160的端部可以钝化，或在端头具有球形件，或具有衬垫，因此不刺穿左心房附件13。图22示出通过棘轮机构使隔膜40沿着伞柱170移动到附件口20上。棘爪机构200在伞柱170上与齿195啮合，向前移动，使隔膜40恰好阻挡附件口20。
图23示出一个贴靠在左心房附件13的口20上的移植片固定物260。固定物260在离开输送导管之后进行膨胀，这样，固定物的壁使固定物密封地紧固在附件口20上。隔膜40折叠或压缩到输送导管中，随着固定物260膨胀而膨胀，并固定在左心房附件13的口20中。
图24示出心房附件被压缩到基本没有空间的左心房附件13。由于空间被缩小，心房附件就没有较大的可以形成血栓的血液空间。在所示的实施例中，盘形件130和弹簧90将左心房附件13拉向隔膜40。虽然图24示出使用盘形件130和弹簧90作用于左心房附件，但是，可以采用任何尽量缩小心房附件空间的方法。除了直接缩小空间外，也可以将一种物质270注入到心房附件中，进一步限制其空间，或者使已经存在在其中的血液凝结。
如图24所示，隔膜40比附件口20大得多。在所有实施例中，均可使用大尺寸的隔膜40，以确保附件口20完全被阻挡。
上述一些装置可以经由皮肤分别输送到左右心房附件13、23。这些装置中可以具有一些增强通过超声波、X线或其它方法进行造影或成象效果的材料，使装置更容易植入并精确地对中定位在心房附件13的口20上。可以在隔膜上、在连接件上或者在锚固件上在关键部位布置一些小珠。由图1可见，导管21经主动脉12到左心室16进入心脏，通过二尖瓣17，然后进入左心房附件13放置上述实施例之一中所述的气孔隔膜40。在图2中，导管21从股静脉进入心脏，通过下腔静脉18到右心房，然后通过卵圆窝19或通过中隔29进入左心房11，然后接近左心房附件13放置气孔隔膜40。图3示出导管21进入右心房附件23的情况。导管21可以通过颈静脉28或股静脉到下腔静脉18进入心脏。
显然，本发明可以采用许多固定方法使隔膜40覆盖心房附件13和23的口20。使用粘合剂、插脚、移植片固定物、锚固件、盘形件、系绳或弹簧的固定方法可以进行任意组合。隔膜也可以置于心房附件13和23之内，或者可以填充心房附件，并配置一种确保隔膜锁紧就位的装置。也可以采用其它未列出的装置使隔膜阻挡血液流入心房附件和阻挡血块离开心房附件。可以将一种物质注入心房附件，以限制其空间，或者使已经存在的血液凝结。
在上述所有实施例中，可以促使心房附件的血液凝结以形成一个固定的大血块。另一方面，心房附件可以填充任何占据空间的物质，例如血纤维蛋白、辅基聚合物(PLLA)、硅氧烷聚合物或者一种输送就位并长时间保持就位的轻型材料。
所有上述用于左心房附件13的实施例也可以用于右心房附件23。另外，本发明可以用于封闭体内其它部位例如结肠系统或支气管肺系统的瘘或联系。本发明也可以用于密封假动脉瘤。当隔膜用于密封假动脉瘤时，将使之强化，并可避免外科手术。
显然，可以根据上述一些技术对本发明进行许多改进并提出其它一些实施例。因此，在所附权利要求书的范围内，除了以上所述之外，还可以在其它情况下实施本发明。

Claims (82)

1.一种防止心房附件血栓进入血流的方法，它包括：用一个隔膜阻挡一个心房附件口，防止血液进入心房附件而在其中形成血栓，并且防止在其中形成的血栓离开。
2.根据权利要求1所述的防止心房附件血栓进入血流的方法，其特征在于，它还包括：使插脚从隔膜穿过附件口延伸进心房附件，将隔膜固定在心房附件口上。
3.根据权利要求2所述的防止心房附件血栓进入血流的方法，其特征在于，它还包括：用延伸进心房附件的插脚刺穿心房附件壁，使隔膜固定就位。
4.根据权利要求2所述的防止心房附件血栓进入血流的方法，其特征在于，它还包括：将球形件固定在插脚的端部上，以防刺伤心房附件内部而导致栓塞。
5.根据权利要求2所述的防止心房附件血栓进入血流的方法，其特征在于，它还包括：通过呈一个圆固定在隔膜上的插脚将隔膜对中定位在附件口上，因此，插脚使隔膜定位在附件口上而在附件口和隔膜之间不留间隙。
6.根据权利要求2所述的防止心房附件血栓进入血流的方法，其特征在于，它还包括：使一个移植片固定物延伸在隔膜和插脚之间，与心房附件口相接合，以便将隔膜固定在附件口上。
7.根据权利要求6所述的防止心房附件血栓进入血流的方法，其特征在于，它还包括：用延伸进心房附件的插脚刺穿心房附件壁，使隔膜固定就位。
8.根据权利要求1所述的防止心房附件血栓进入血流的方法，其特征在于，它还包括：使移植片固定物的插脚穿过心房附件口延伸进心房附件，使隔膜恰好抵住心房附件口，从而将隔膜固定在心房附件口上。
9.根据权利要求1所述的防止心房附件血栓进入血流的方法，其特征在于，它还包括：使一个锚固件延伸进或穿过心房附件壁，在心房附件和隔膜之间固定一根系绳，使隔膜恰好抵住心房附件口，从而将隔膜固定在心房附件口上。
10.根据权利要求9所述的防止心房附件血栓进入血流的方法，其特征在于，它还包括：使用一根弹性系绳将隔膜密封在心房附件口上。
11.根据权利要求1所述的防止心房附件血栓进入血流的方法，其特征在于，它还包括：将一个锚固件插入心房附件壁，在锚固件和心房附件之间固定一个弹簧，使隔膜抵住心房附件口，从而将隔膜固定在心房附件口上。
12.根据权利要求1所述的防止心房附件血栓进入血流的方法，其特征在于，它还包括：使用一个同隔膜相连接的螺旋弹簧恰好填充心房附件，将隔膜密封在心房附件口上。
13.根据权利要求1所述的防止心房附件血栓进入血流的方法，其特征在于，它还包括：将隔膜粘接在心房附件口上。
14.根据权利要求1所述的防止心房附件血栓进入血流的方法，其特征在于，它还包括：使一个盘形件延伸穿过心房附件壁，在心房附件和隔膜之间固定一根系绳，使隔膜恰好抵住心房附件口，从而将隔膜固定在心房附件口上。
15.根据权利要求14所述的防止心房附件血栓进入血流的方法，其特征在于，它还包括：使用一根弹性系绳，使隔膜恰好抵住心房附件口。
16.根据权利要求1所述的防止心房附件血栓进入血流的方法，其特征在于，它还包括：使一个盘形件延伸穿过心房附件壁，在心房附件和隔膜之间固定一个弹簧，使隔膜恰好抵住心房附件口，从而将隔膜固定在心房附件口上。
17.根据权利要求1所述的防止心房附件血栓进入血流的方法，其特征在于，它还包括：用真空装置排空心房附件，从中去除血栓，并且压缩心房附件。
18.根据权利要求1所述的防止心房附件血栓进入血流的方法，其特征在于，它还包括：用一种隔膜材料填充心房附件，阻挡心房附件口。
19.根据权利要求1所述的防止心房附件血栓进入血流的方法，其特征在于，它还包括：使一个伞柱上的伞撑在处于闭合位置时延伸进心房附件，在心房附件中打开这些伞撑，这样，伞撑与心房附件壁相接合而不能从附件口抽出，然后使隔膜在伞柱上移动，在附件口对面固定就位，将附件口壁保持在隔膜和伞撑之间，从而将隔膜固定在心房附件口上。
20.根据权利要求1所述的防止心房附件血栓进入血流的方法，其特征在于，它还包括：使一个可折叠的移植片固定物延伸进附件口，这样，固定物膨胀并与附件口的周边相接合，将一个可折叠的隔膜固定在固定物的管腔上，这样，打开固定物，使隔膜在固定物的管腔上展开，阻挡附件口，从而将隔膜固定在心房附件口上。
21.根据权利要求1所述的防止心房附件血栓进入血流的方法，其特征在于，它还包括：用一种抗血凝药物涂覆隔膜，以防血栓形成。
22.根据权利要求1所述的防止心房附件血栓进入血流的方法，其特征在于，它还包括：使用一个促使内皮细胞在隔膜上生长的气孔隔膜，从而在隔膜上形成一个防止血栓形成的细胞壁。
23.根据权利要求1所述的防止心房附件血栓进入血流的方法，其特征在于，它还包括：将一种密封材料注入心房附件，使隔膜密封在附件口上，以防漏出。
24.根据权利要求1所述的防止心房附件血栓进入血流的方法，其特征在于，它还包括：将一种填料注入心房附件，缩小心房附件的空间。
25.根据权利要求1所述的防止心房附件血栓进入血流的方法，其特征在于，它还包括：将一种血凝物质注入心房附件，使血液在其中凝结，以防流出心房附件。
26.根据权利要求1所述的防止心房附件血栓进入血流的方法，其特征在于，它还包括：将一种化学烧蚀剂注入心房附件，烧蚀心肌组织，从而防止心房纤维性颤动的电传播。
27.根据权利要求1所述的防止心房附件血栓进入血流的方法，其特征在于，它还包括：使用一个对中定位装置，将隔膜对中定位在心房附件口上，以形成良好密封。
28.根据权利要求27所述的防止心房附件血栓进入血流的方法，其特征在于，使隔膜对中定位在附件口上的对中定位装置包括：将一个对中定位凸缘固定在隔膜上，用于插入到心房附件口中。
29.根据权利要求27所述的防止心房附件血栓进入血流的方法，其特征在于，使隔膜对中定位在附件口上的对中定位装置包括：
将一个对中定位凸缘固定在隔膜上，用于插入到心房附件口中，
将一个定位件固定到心房附件壁上，使定位件与一个位于定位件和隔膜之间的弹簧相连接，使隔膜抵住心房附件口，
将定位索从弹簧系到隔膜上，使隔膜对中定位在心房附件口上。
30.根据权利要求27所述的防止心房附件血栓进入血流的方法，其特征在于，使隔膜对中定位在附件口上的对中定位装置包括：
将一个对中定位凸缘固定在隔膜上，用于插入到心房附件口中，
将一个定位件固定到心房附件壁上，使定位件与一个位于定位件和隔膜之间的弹簧相连接，使隔膜抵住心房附件口，
将定位索从弹簧系到隔膜的对中定位凸缘上，使隔膜对中定位在心房附件口上。
31.根据权利要求27所述的防止心房附件血栓进入血流的方法，其特征在于，使隔膜对中定位在附件口上的对中定位装置包括：
将一个定位件固定到心房附件壁上，使定位件与一个位于定位件和隔膜之间的弹簧相连接，使隔膜抵住心房附件口，
将定位索从弹簧系到隔膜上，使隔膜对中定位在心房附件口上。
32.根据权利要求27所述的防止心房附件血栓进入血流的方法，其特征在于，使隔膜对中定位在附件口上的对中定位装置包括：
将一个对中定位凸缘固定在隔膜上，用于插入到心房附件口中，
将一个定位件固定到心房附件壁上，使定位件与一个位于定位件和隔膜之间的系绳相连接，使隔膜抵住心房附件口，
将定位索从系绳系到隔膜的对中定位凸缘上，使隔膜对中定位在心房附件口上。
33.根据权利要求27所述的防止心房附件血栓进入血流的方法，其特征在于，使隔膜对中定位在附件口上的对中定位装置包括：
将一个定位件固定到心房附件壁上，使定位件与一个位于定位件和隔膜之间的系绳相连接，使隔膜抵住心房附件口，
将定位索从系绳系到隔膜上，使隔膜对中定位在心房附件口上。
34.根据权利要求27所述的防止心房附件血栓进入血流的方法，其特征在于，使隔膜对中定位在附件口上的对中定位装置包括：
将一个对中定位凸缘固定在隔膜上，用于插入到心房附件口中，
将一个定位件固定到心房附件壁上，使定位件与一个位于定位件和隔膜之间的系绳相连接，使隔膜抵住心房附件口，
将定位索从系绳系到隔膜上，使隔膜对中定位在心房附件口上。
35.根据权利要求1所述的防止心房附件血栓进入血流的方法，其特征在于，它还包括：将标示件固定在隔膜上，用于在隔膜置于心房附件口上时观察隔膜的位置。
36.根据权利要求1所述的防止心房附件血栓进入血流的方法，其特征在于，它还包括：将传感器固定在隔膜上，用于提供关于患者的信息。
37.一种阻挡一个心房附件口的隔膜，它包括：
一个隔膜，
一个用隔膜阻挡心房附件口的装置，使血液不进入心房附件形成血栓，并且使血栓不离开心房附件。
38.根据权利要求37所述的阻挡一个心房附件口的隔膜，其特征在于，阻挡心房附件口的装置包括一个置于附件口上的隔膜，隔膜具有插脚，这些插脚延伸穿过附件口，紧靠在心房附件壁上，使隔膜牢牢固定在附件口上。
39.根据权利要求38所述的阻挡一个心房附件口的隔膜，其特征在于，记忆合金插脚用于在心房附件之内膨胀到所需形状，使隔膜牢牢固定在附件口上。
40.根据权利要求37所述的阻挡一个心房附件口的隔膜，其特征在于，布置在每个插脚端头上的一个球形件防止插脚刺穿心房附件壁而形成栓塞。
41.根据权利要求37所述的阻挡一个心房附件口的隔膜，其特征在于，插脚刺穿心房附件壁，使隔膜固定就位。
42.根据权利要求37所述的阻挡一个心房附件口的隔膜，其特征在于，插脚呈一个圆固定在隔膜上，这样，插脚就会使隔膜对中定位在附件口上。
43.根据权利要求37所述的阻挡一个心房附件口的隔膜，其特征在于，隔膜和插脚之间的一个移植片固定物嵌入在心房附件口的口径中，使隔膜在附件口上牢固地固定就位。
44.根据权利要求43所述的阻挡一个心房附件口的隔膜，其特征在于，插脚刺穿心房附件壁，使隔膜固定就位。
45.根据权利要求37所述的阻挡一个心房附件口的隔膜，其特征在于，阻挡附件口的装置包括移植片固定物插脚，固定物的这些插脚固定在隔膜上，并且穿过心房附件口延伸到心房附件内。
46.根据权利要求45所述的阻挡一个心房附件口的隔膜，其特征在于，记忆合金的移植片固定物插脚用于在心房附件之内膨胀到所需形状，使隔膜牢牢固定在附件口上。
47.根据权利要求37所述的阻挡一个心房附件口的隔膜，其特征在于，阻挡附件口的装置包括一个进入或穿过心房附件壁的锚固件以及一根连接锚固件和隔膜的系绳，使隔膜牢固地固定在心房附件口上。
48.根据权利要求47所述的阻挡一个心房附件口的隔膜，其特征在于，系绳是弹性的，用于牵拉隔膜使之紧靠在心房附件口上。
49.根据权利要求37所述的阻挡一个心房附件口的隔膜，其特征在于，阻挡附件口的装置包括一个进入或穿过心房附件壁的锚固件以及一根连接锚固件和隔膜的弹簧，使隔膜牢固地固定在心房附件口上。
50.根据权利要求37所述的阻挡一个心房附件口的隔膜，其特征在于，阻挡附件口的装置包括一个填充心房附件并与隔膜相连接的螺旋弹簧，使隔膜牢固地固定在心房附件口上。
51.根据权利要求37所述的阻挡一个心房附件口的隔膜，其特征在于，阻挡附件口的装置在隔膜上具有一种粘合剂，使隔膜固定在心房附件口上。
52.根据权利要求37所述的阻挡一个心房附件口的隔膜，其特征在于，一个真空装置采用吸出术从心房附件去除血栓并缩小心房附件的空间。
53.根据权利要求37所述的阻挡一个心房附件口的隔膜，其特征在于，阻挡附件口的装置包括一个布置在心房附件壁相反侧面上的盘形件以及一个连接盘形件和隔膜的弹簧，使隔膜牢固地固定在心房附件口上。
54.根据权利要求37所述的阻挡一个心房附件口的隔膜，其特征在于，阻挡附件口的装置包括一个布置在心房附件壁相反侧面上的盘形件以及一个连接盘形件和隔膜的系绳，使隔膜牢固地固定在心房附件口上。
55.根据权利要求37所述的阻挡一个心房附件口的隔膜，其特征在于，阻挡附件口的装置包括一种填充心房附件的隔膜材料。
56.根据权利要求37所述的阻挡一个心房附件口的隔膜，其特征在于，阻挡附件口的装置包括一个伞柱，在伞柱的一端具有伞撑，
一个伞撑打开机构用于使伞撑从伞撑靠近伞柱的闭合位置展开到伞撑从伞柱径向张开的打开位置，这样，伞撑可以在闭合位置通过一个心房附件口插入，然后打开，使伞撑与心房附件壁接合，而不能从附件口抽出，
伞柱具有齿，
隔膜中的一个棘爪用于形成一个与齿相配合的棘轮机构，使隔膜沿伞柱的长度移动进入锁定位置，确保隔膜固定在与伞撑相对的心房附件口上。
57.根据权利要求37所述的阻挡一个心房附件口的隔膜，其特征在于，阻挡附件口的装置包括一个用于插入到附件口中的可折叠移植片固定物，固定物膨胀并与附件口的周边相接合，将一个可折叠隔膜固定在固定物的管腔上，这样，打开固定物，使隔膜展开在固定物的管腔上，从而阻挡附件口。
58.根据权利要求37所述的阻挡一个心房附件口的隔膜，其特征在于，隔膜上的一种防血凝药物防止血栓形成。
59.根据权利要求37所述的阻挡一个心房附件口的隔膜，其特征在于，一种注入心房附件中的化学烧蚀剂烧蚀心肌组织，从而防止心房纤维性颤动的电传播。
60.根据权利要求37所述的阻挡一个心房附件口的隔膜，其特征在于，隔膜是一个促使内皮细胞在隔膜的孔中生长的气孔隔膜，因此在隔膜上形成一个防止血栓形成的细胞壁。
61.根据权利要求37所述的阻挡一个心房附件口的隔膜，其特征在于，隔膜是一个促使内皮细胞在隔膜的孔中生长的金属网，因此在隔膜上形成一个防止血栓形成的细胞壁。
62.根据权利要求37所述的阻挡一个心房附件口的隔膜，其特征在于，一种物质注入心房附件中，使隔膜密封以防漏出。
63.根据权利要求37所述的阻挡一个心房附件口的隔膜，其特征在于，一种物质注入心房附件中，填充心房附件并缩小其空间。
64.根据权利要求37所述的阻挡一个心房附件口的隔膜，其特征在于，一种血凝剂注入心房附件中，使血液在其中凝结，使之不能流出心房附件。
65.根据权利要求37所述的阻挡一个心房附件口的隔膜，其特征在于，隔膜具有一个使隔膜对中定位在心房附件口上的装置。
66.根据权利要求65所述的阻挡一个心房附件口的隔膜，其特征在于，使隔膜对中定位在心房附件口上的装置包括：一个位于隔膜上、用于布置在附件口中的对中定位凸缘。
67.根据权利要求65所述的阻挡一个心房附件口的隔膜，其特征在于，使隔膜对中定位在心房附件口上的装置包括：
一个用于使一个弹簧固定到心房附件的一个壁上并且使弹簧的另一端固定在隔膜上的装置，
系在弹簧上并与隔膜相连接的、用于使隔膜对中定位在附件口上的定位索。
68.根据权利要求65所述的阻挡一个心房附件口的隔膜，其特征在于，
一个位于隔膜上、用于布置在附件口中的对中定位凸缘，
一个用于使一个弹簧固定到心房附件的一个壁上并且使弹簧的另一端固定在隔膜上的装置，
系在弹簧上并与隔膜相连接的、用于使隔膜对中定位在附件口上的定位索。
69.根据权利要求65所述的阻挡一个心房附件口的隔膜，其特征在于，
一个位于隔膜上、用于布置在附件口中的对中定位凸缘，
一个用于使一个弹簧固定到心房附件的一个壁上并且使弹簧的另一端固定在隔膜上的装置，
系在弹簧上并与隔膜的对中定位凸缘相连接的、用于使隔膜对中定位在附件口上的定位索。
70.根据权利要求65所述的阻挡一个心房附件口的隔膜，其特征在于，使隔膜对中定位在心房附件口上的装置包括：
一个用于使一根系绳固定到心房附件的一个壁上并且使系绳的另一端固定在隔膜上的装置，
系在系绳上并与隔膜相连接的、用于使隔膜对中定位在附件口上的定位索。
71.根据权利要求65所述的阻挡一个心房附件口的隔膜，其特征在于，
一个位于隔膜上、用于布置在附件口中的对中定位凸缘，
一个用于使一个系绳固定到心房附件的一个壁上并且使系绳的另一端固定在隔膜上的装置，
系在系绳上并与隔膜相连接的、用于使隔膜对中定位在附件口上的定位索。
72.根据权利要求65所述的阻挡一个心房附件口的隔膜，其特征在于，
一个位于隔膜上、用于布置在附件口中的对中定位凸缘，
一个用于使一个系绳固定到心房附件的一个壁上并且使系绳的另一端固定在隔膜上的装置，
系在系绳上并与隔膜的对中定位凸缘相连接的、用于使隔膜对中定位在附件口上的定位索。
73.根据权利要求65所述的阻挡一个心房附件口的隔膜，其特征在于，使隔膜对中定位在心房附件口上的装置包括：固定在隔膜上的标示件，用于在隔膜置于心房附件口上时观察隔膜的位置。
74.根据权利要求37所述的阻挡一个心房附件口的隔膜，其特征在于，至少一个传感器固定在隔膜上，用于对患者进行监测。
75.一种阻塞患者体内孔口的方法，它包括：
用导管无损害地将隔膜插入孔口中以阻挡孔口，
使隔膜紧靠孔口，用一个装置将隔膜固定在孔口对面的体组织上，从而将隔膜固定就位。
76.根据权利要求75所述的阻塞患者体内孔口的方法，其特征在于，它还包括将隔膜固定在一个假动脉瘤上。
77.根据权利要求75所述的阻塞患者体内孔口的方法，其特征在于，它还包括将隔膜固定在一个瘘上。
78.根据权利要求75所述的阻塞患者体内孔口的方法，其特征在于，它还包括将隔膜固定在一个心房附件口上。
79.一种阻塞患者体内孔口的隔膜，它包括：
一个隔膜，
通过将隔膜置于孔口一侧而使隔膜固定在孔口上的装置，和使一个连接件在孔口的相对一侧固定到体组织上的装置。
80.根据权利要求79所述的阻塞患者体内孔口的隔膜，其特征在于，隔膜覆盖一个假动脉瘤。
81.根据权利要求79所述的阻塞患者体内孔口的隔膜，其特征在于，隔膜覆盖一个瘘。
82.根据权利要求79所述的阻塞患者体内孔口的隔膜，其特征在于，隔膜覆盖一个心房附件口。
CN00816176A 1999-10-27 2000-10-23 左心房附件口的阻挡装置 Pending CN1399531A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/428,008 US6551303B1 (en) 1999-10-27 1999-10-27 Barrier device for ostium of left atrial appendage
US09/428,008 1999-10-27

Publications (1)

Publication Number Publication Date
CN1399531A true CN1399531A (zh) 2003-02-26

Family

ID=23697195

Family Applications (1)

Application Number Title Priority Date Filing Date
CN00816176A Pending CN1399531A (zh) 1999-10-27 2000-10-23 左心房附件口的阻挡装置

Country Status (11)

Country Link
US (5) US6551303B1 (zh)
EP (2) EP1225843B1 (zh)
JP (1) JP2003512129A (zh)
CN (1) CN1399531A (zh)
AT (1) ATE288231T1 (zh)
AU (1) AU779124B2 (zh)
CA (1) CA2388603A1 (zh)
DE (1) DE60017928T2 (zh)
ES (1) ES2232516T3 (zh)
IL (1) IL149300A0 (zh)
WO (1) WO2001030268A1 (zh)

Cited By (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100413471C (zh) * 2004-06-25 2008-08-27 深圳市先健科技股份有限公司 输送左心耳闭塞装置的输送器
CN103040492A (zh) * 2013-01-09 2013-04-17 何泽锋 自动控制收缩的经口输送钉砧装置
CN103118602A (zh) * 2010-06-11 2013-05-22 随行医疗技术公司 用于经心尖介入和闭合的系统和方法
CN103536366A (zh) * 2013-10-22 2014-01-29 同济大学 一种用于柔性微创手术机械手的自动锚爪支撑装置
CN104039241A (zh) * 2011-11-08 2014-09-10 W.L.戈尔及同仁股份有限公司 密封装置和递送系统
CN105050540A (zh) * 2013-03-22 2015-11-11 爱德华兹生命科学公司 用于增加通过左心耳的流动的设备和方法
CN105491964A (zh) * 2013-06-26 2016-04-13 W.L.戈尔及同仁股份有限公司 空间填充装置
CN105520765A (zh) * 2016-01-29 2016-04-27 上海形状记忆合金材料有限公司 凹入式左心耳封堵器
CN106075619A (zh) * 2016-08-26 2016-11-09 复旦大学附属中山医院 一种冠状静脉血流引流器
US9510835B2 (en) 2005-10-19 2016-12-06 Pulsar Vascular, Inc. Methods and systems for endovascularly clipping and repairing lumen and tissue defects
CN106214289A (zh) * 2016-09-05 2016-12-14 广东脉搏医疗科技有限公司 一种心脏减容植入体
CN106344100A (zh) * 2016-10-11 2017-01-25 北京工业大学 左心耳封堵器
CN106413589A (zh) * 2014-06-11 2017-02-15 奥特鲁泰克控股有限公司 左心耳封堵器
US9615831B2 (en) 2008-09-05 2017-04-11 Pulsar Vascular, Inc. Systems and methods for supporting or occluding a physiological opening or cavity
US9636117B2 (en) 2011-10-05 2017-05-02 Pulsar Vascular, Inc. Devices, systems and methods for enclosing an anatomical opening
CN107137114A (zh) * 2011-06-17 2017-09-08 库拉希尔公司 用于瘘治疗的装置及方法
CN107595347A (zh) * 2017-09-25 2018-01-19 潘湘斌 一种可重复收放的左心耳封堵器组件及其介入方法
CN107750145A (zh) * 2015-06-19 2018-03-02 皇家飞利浦有限公司 针对心脏组织的可植入医学设备和系统
US10004510B2 (en) 2011-06-03 2018-06-26 Pulsar Vascular, Inc. Systems and methods for enclosing an anatomical opening, including shock absorbing aneurysm devices
CN109620490A (zh) * 2018-12-17 2019-04-16 中国医学科学院北京协和医院 一种爪形胆管及胰腺支架取出器械
US10335153B2 (en) 2009-09-04 2019-07-02 Pulsar Vascular, Inc. Systems and methods for enclosing an anatomical opening
CN110612073A (zh) * 2017-01-05 2019-12-24 和谐发展集团有限公司 用于捕获反流射流、体积及力以实现心室功能及重塑的可扩张装置
US10624647B2 (en) 2011-06-03 2020-04-21 Pulsar Vascular, Inc. Aneurysm devices with additional anchoring mechanisms and associated systems and methods
CN111110400A (zh) * 2019-12-09 2020-05-08 先健科技(深圳)有限公司 心脏瓣膜系绳及具有其的心脏瓣膜组件
CN112336409A (zh) * 2019-08-07 2021-02-09 合硕生技股份有限公司 骨骼钻孔盖固定装置
US11167122B2 (en) 2018-03-05 2021-11-09 Harmony Development Group, Inc. Force transducting implant system for the mitigation of atrioventricular pressure gradient loss and the restoration of healthy ventricular geometry
CN113855133A (zh) * 2021-09-29 2021-12-31 复旦大学附属中山医院 一种血管吻合口球囊血流隔绝器
US11883289B2 (en) 2017-06-28 2024-01-30 Harmony Development Group, Inc. Force transducting inflatable implant system including a dual force annular transduction implant
CN113855133B (zh) * 2021-09-29 2024-04-09 复旦大学附属中山医院 一种血管吻合口球囊血流隔绝器

Families Citing this family (507)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6482224B1 (en) * 1996-08-22 2002-11-19 The Trustees Of Columbia University In The City Of New York Endovascular flexible stapling device
US6241762B1 (en) 1998-03-30 2001-06-05 Conor Medsystems, Inc. Expandable medical device with ductile hinges
US7208010B2 (en) 2000-10-16 2007-04-24 Conor Medsystems, Inc. Expandable medical device for delivery of beneficial agent
US7314477B1 (en) 1998-09-25 2008-01-01 C.R. Bard Inc. Removable embolus blood clot filter and filter delivery unit
US7044134B2 (en) * 1999-11-08 2006-05-16 Ev3 Sunnyvale, Inc Method of implanting a device in the left atrial appendage
US7128073B1 (en) * 1998-11-06 2006-10-31 Ev3 Endovascular, Inc. Method and device for left atrial appendage occlusion
US7713282B2 (en) * 1998-11-06 2010-05-11 Atritech, Inc. Detachable atrial appendage occlusion balloon
US6752813B2 (en) 1999-04-09 2004-06-22 Evalve, Inc. Methods and devices for capturing and fixing leaflets in valve repair
US6488689B1 (en) 1999-05-20 2002-12-03 Aaron V. Kaplan Methods and apparatus for transpericardial left atrial appendage closure
US8257428B2 (en) * 1999-08-09 2012-09-04 Cardiokinetix, Inc. System for improving cardiac function
US8529430B2 (en) * 2002-08-01 2013-09-10 Cardiokinetix, Inc. Therapeutic methods and devices following myocardial infarction
US7303526B2 (en) * 1999-08-09 2007-12-04 Cardiokinetix, Inc. Device for improving cardiac function
US10307147B2 (en) 1999-08-09 2019-06-04 Edwards Lifesciences Corporation System for improving cardiac function by sealing a partitioning membrane within a ventricle
US9694121B2 (en) 1999-08-09 2017-07-04 Cardiokinetix, Inc. Systems and methods for improving cardiac function
US7674222B2 (en) * 1999-08-09 2010-03-09 Cardiokinetix, Inc. Cardiac device and methods of use thereof
US20060229491A1 (en) * 2002-08-01 2006-10-12 Cardiokinetix, Inc. Method for treating myocardial rupture
US8246671B2 (en) 1999-08-09 2012-08-21 Cardiokinetix, Inc. Retrievable cardiac devices
US8377114B2 (en) 1999-08-09 2013-02-19 Cardiokinetix, Inc. Sealing and filling ventricular partitioning devices to improve cardiac function
US7582051B2 (en) * 2005-06-10 2009-09-01 Cardiokinetix, Inc. Peripheral seal for a ventricular partitioning device
US20030109770A1 (en) * 1999-08-09 2003-06-12 Sharkey Hugh R. Device with a porous membrane for improving cardiac function
AU5812299A (en) * 1999-09-07 2001-04-10 Microvena Corporation Retrievable septal defect closure device
US6231561B1 (en) 1999-09-20 2001-05-15 Appriva Medical, Inc. Method and apparatus for closing a body lumen
US6551303B1 (en) * 1999-10-27 2003-04-22 Atritech, Inc. Barrier device for ostium of left atrial appendage
US6689150B1 (en) * 1999-10-27 2004-02-10 Atritech, Inc. Filter apparatus for ostium of left atrial appendage
US6994092B2 (en) * 1999-11-08 2006-02-07 Ev3 Sunnyvale, Inc. Device for containing embolic material in the LAA having a plurality of tissue retention structures
US7056294B2 (en) * 2000-04-13 2006-06-06 Ev3 Sunnyvale, Inc Method and apparatus for accessing the left atrial appendage
US6551344B2 (en) * 2000-04-26 2003-04-22 Ev3 Inc. Septal defect occluder
US6645221B1 (en) 2000-05-30 2003-11-11 Zuli, Holdings Ltd. Active arterial embolization filter
US6440152B1 (en) * 2000-07-28 2002-08-27 Microvena Corporation Defect occluder release assembly and method
US9332992B2 (en) 2004-08-05 2016-05-10 Cardiokinetix, Inc. Method for making a laminar ventricular partitioning device
US7762943B2 (en) * 2004-03-03 2010-07-27 Cardiokinetix, Inc. Inflatable ventricular partitioning device
US9078660B2 (en) * 2000-08-09 2015-07-14 Cardiokinetix, Inc. Devices and methods for delivering an endocardial device
US8398537B2 (en) * 2005-06-10 2013-03-19 Cardiokinetix, Inc. Peripheral seal for a ventricular partitioning device
US10064696B2 (en) 2000-08-09 2018-09-04 Edwards Lifesciences Corporation Devices and methods for delivering an endocardial device
US9332993B2 (en) 2004-08-05 2016-05-10 Cardiokinetix, Inc. Devices and methods for delivering an endocardial device
US7862500B2 (en) * 2002-08-01 2011-01-04 Cardiokinetix, Inc. Multiple partitioning devices for heart treatment
US20060030881A1 (en) 2004-08-05 2006-02-09 Cardiokinetix, Inc. Ventricular partitioning device
US7399271B2 (en) * 2004-01-09 2008-07-15 Cardiokinetix, Inc. Ventricular partitioning device
JP2004506469A (ja) * 2000-08-18 2004-03-04 アトリテック，　インコーポレイテッド 心耳からの血流をろ過するための拡張可能な埋め込みデバイス
JP2004508879A (ja) * 2000-09-21 2004-03-25 アトリテック，　インコーポレイテッド 心耳内にデバイスを移植するための装置
US6666861B1 (en) * 2000-10-05 2003-12-23 James R. Grabek Atrial appendage remodeling device and method
ATE300255T1 (de) 2000-10-16 2005-08-15 Conor Medsystems Inc Expandierbare medizinische vorrichtung zum zuführen eines heilmittels
US8690910B2 (en) 2000-12-07 2014-04-08 Integrated Vascular Systems, Inc. Closure device and methods for making and using them
US6953464B2 (en) * 2001-02-21 2005-10-11 Novare Surgical Systems, Inc. Anastomosis occlusion device
US6702763B2 (en) * 2001-02-28 2004-03-09 Chase Medical, L.P. Sizing apparatus and method for use during ventricular restoration
US20020133227A1 (en) * 2001-02-28 2002-09-19 Gregory Murphy Ventricular restoration patch apparatus and method of use
US8961541B2 (en) 2007-12-03 2015-02-24 Cardio Vascular Technologies Inc. Vascular closure devices, systems, and methods of use
US8992567B1 (en) 2001-04-24 2015-03-31 Cardiovascular Technologies Inc. Compressible, deformable, or deflectable tissue closure devices and method of manufacture
US20080109030A1 (en) 2001-04-24 2008-05-08 Houser Russell A Arteriotomy closure devices and techniques
US7338514B2 (en) * 2001-06-01 2008-03-04 St. Jude Medical, Cardiology Division, Inc. Closure devices, related delivery methods and tools, and related methods of use
EP1392394A4 (en) * 2001-06-04 2005-05-18 Albert Einstein Healthcare Network CARDIAC STIMULATION APPARATUS WITH FILTER FOR FILTERING BLOOD CLOTS AND ATRIAL PACE MAKER
US7011671B2 (en) * 2001-07-18 2006-03-14 Atritech, Inc. Cardiac implant device tether system and method
US7572288B2 (en) * 2001-07-20 2009-08-11 Microvention, Inc. Aneurysm treatment device and method of use
US8252040B2 (en) * 2001-07-20 2012-08-28 Microvention, Inc. Aneurysm treatment device and method of use
FR2828263B1 (fr) 2001-08-03 2007-05-11 Philipp Bonhoeffer Dispositif d'implantation d'un implant et procede d'implantation du dispositif
US20040249443A1 (en) * 2001-08-20 2004-12-09 Shanley John F. Expandable medical device for treating cardiac arrhythmias
US7842083B2 (en) 2001-08-20 2010-11-30 Innovational Holdings, Llc. Expandable medical device with improved spatial distribution
US6702835B2 (en) 2001-09-07 2004-03-09 Core Medical, Inc. Needle apparatus for closing septal defects and methods for using such apparatus
US6776784B2 (en) 2001-09-06 2004-08-17 Core Medical, Inc. Clip apparatus for closing septal defects and methods of use
US20060052821A1 (en) 2001-09-06 2006-03-09 Ovalis, Inc. Systems and methods for treating septal defects
US20080015633A1 (en) * 2001-09-06 2008-01-17 Ryan Abbott Systems and Methods for Treating Septal Defects
US20030050648A1 (en) 2001-09-11 2003-03-13 Spiration, Inc. Removable lung reduction devices, systems, and methods
US6863683B2 (en) 2001-09-19 2005-03-08 Abbott Laboratoris Vascular Entities Limited Cold-molding process for loading a stent onto a stent delivery system
US6592594B2 (en) 2001-10-25 2003-07-15 Spiration, Inc. Bronchial obstruction device deployment system and method
US20060292206A1 (en) 2001-11-26 2006-12-28 Kim Steven W Devices and methods for treatment of vascular aneurysms
EP1467661A4 (en) 2001-12-19 2008-11-05 Nmt Medical Inc SEPTAL SHUTTER AND ASSOCIATED METHODS
US7318833B2 (en) * 2001-12-19 2008-01-15 Nmt Medical, Inc. PFO closure device with flexible thrombogenic joint and improved dislodgement resistance
EP1471835A4 (en) * 2002-01-14 2008-03-19 Nmt Medical Inc METHOD AND DEVICE FOR CLOSING AN OPEN FORM OVALE (PFO)
US9204956B2 (en) 2002-02-20 2015-12-08 C. R. Bard, Inc. IVC filter with translating hooks
US6749621B2 (en) 2002-02-21 2004-06-15 Integrated Vascular Systems, Inc. Sheath apparatus and methods for delivering a closure device
US20030181922A1 (en) 2002-03-20 2003-09-25 Spiration, Inc. Removable anchored lung volume reduction devices and methods
US20030216769A1 (en) 2002-05-17 2003-11-20 Dillard David H. Removable anchored lung volume reduction devices and methods
US9241695B2 (en) * 2002-03-25 2016-01-26 W.L. Gore & Associates, Inc. Patent foramen ovale (PFO) closure clips
US20030195553A1 (en) * 2002-04-12 2003-10-16 Scimed Life Systems, Inc. System and method for retaining vaso-occlusive devices within an aneurysm
US20030199887A1 (en) * 2002-04-23 2003-10-23 David Ferrera Filamentous embolization device and method of use
US7976564B2 (en) 2002-05-06 2011-07-12 St. Jude Medical, Cardiology Division, Inc. PFO closure devices and related methods of use
DE60308501T2 (de) * 2002-05-08 2007-10-04 Radi Medical Systems Ab Lösliche medizinische dichtungsvorrichtung
US7431729B2 (en) * 2002-06-05 2008-10-07 Nmt Medical, Inc. Patent foramen ovale (PFO) closure device with radial and circumferential support
US7025778B2 (en) * 2002-06-07 2006-04-11 Endovascular Technologies, Inc. Endovascular graft with pressure, temperature, flow and voltage sensors
US20040098043A1 (en) * 2002-07-09 2004-05-20 Trout Hugh H. Delivery apparatus for use during a surgical procedure and method of using the same
CA2492700C (en) * 2002-07-31 2010-10-12 Abbott Laboratories Vascular Enterprises, Limited Apparatus for sealing surgical punctures
US20040034386A1 (en) * 2002-08-19 2004-02-19 Michael Fulton Aneurysm stent
US8075585B2 (en) * 2002-08-29 2011-12-13 Stryker Corporation Device and method for treatment of a vascular defect
US20040122362A1 (en) * 2002-09-10 2004-06-24 Houser Russell A. Pseudo aneurysm repair system
AU2003284976A1 (en) 2002-10-25 2004-05-13 Nmt Medical, Inc. Expandable sheath tubing
US20040088038A1 (en) * 2002-10-30 2004-05-06 Houdin Dehnad Porous metal for drug-loaded stents
US20040093017A1 (en) * 2002-11-06 2004-05-13 Nmt Medical, Inc. Medical devices utilizing modified shape memory alloy
WO2004043266A2 (en) * 2002-11-07 2004-05-27 Nmt Medical, Inc. Patent foramen ovale (pfo) closure with magnetic force
US7481821B2 (en) 2002-11-12 2009-01-27 Thomas J. Fogarty Embolization device and a method of using the same
AU2003294682A1 (en) * 2002-12-09 2004-06-30 Nmt Medical, Inc. Septal closure devices
US7195628B2 (en) * 2002-12-11 2007-03-27 St. Jude Medical, Atrial Fibrillation Division, Inc. Atrial fibrillation therapy with pulmonary vein support
US8435550B2 (en) 2002-12-16 2013-05-07 Abbot Cardiovascular Systems Inc. Anti-proliferative and anti-inflammatory agent combination for treatment of vascular disorders with an implantable medical device
US20040260382A1 (en) 2003-02-12 2004-12-23 Fogarty Thomas J. Intravascular implants and methods of using the same
US7658747B2 (en) 2003-03-12 2010-02-09 Nmt Medical, Inc. Medical device for manipulation of a medical implant
DE602004018282D1 (de) * 2003-03-17 2009-01-22 Ev3 Endovascular Inc Stent mit laminierter dünnfilmverbund
US7186251B2 (en) 2003-03-27 2007-03-06 Cierra, Inc. Energy based devices and methods for treatment of patent foramen ovale
US6939348B2 (en) 2003-03-27 2005-09-06 Cierra, Inc. Energy based devices and methods for treatment of patent foramen ovale
US8021362B2 (en) 2003-03-27 2011-09-20 Terumo Kabushiki Kaisha Methods and apparatus for closing a layered tissue defect
US7165552B2 (en) * 2003-03-27 2007-01-23 Cierra, Inc. Methods and apparatus for treatment of patent foramen ovale
JP4382087B2 (ja) 2003-03-27 2009-12-09 テルモ株式会社 卵円孔開存の治療方法および装置
US7293562B2 (en) * 2003-03-27 2007-11-13 Cierra, Inc. Energy based devices and methods for treatment of anatomic tissue defects
US7972330B2 (en) 2003-03-27 2011-07-05 Terumo Kabushiki Kaisha Methods and apparatus for closing a layered tissue defect
US7100616B2 (en) 2003-04-08 2006-09-05 Spiration, Inc. Bronchoscopic lung volume reduction method
US20040267306A1 (en) 2003-04-11 2004-12-30 Velocimed, L.L.C. Closure devices, related delivery methods, and related methods of use
US8372112B2 (en) 2003-04-11 2013-02-12 St. Jude Medical, Cardiology Division, Inc. Closure devices, related delivery methods, and related methods of use
US7597704B2 (en) * 2003-04-28 2009-10-06 Atritech, Inc. Left atrial appendage occlusion device with active expansion
EP1472996B1 (en) * 2003-04-30 2009-09-30 Medtronic Vascular, Inc. Percutaneously delivered temporary valve
US10646229B2 (en) 2003-05-19 2020-05-12 Evalve, Inc. Fixation devices, systems and methods for engaging tissue
CN1852688A (zh) * 2003-05-19 2006-10-25 斯托特药物集团公司 组织扩张装置及用于治疗介入的相关方法
US7311701B2 (en) * 2003-06-10 2007-12-25 Cierra, Inc. Methods and apparatus for non-invasively treating atrial fibrillation using high intensity focused ultrasound
JP4499719B2 (ja) * 2003-07-03 2010-07-07 ラディ・メディカル・システムズ・アクチェボラーグ 傷縫合および封止用具
ES2428967T3 (es) 2003-07-14 2013-11-12 W.L. Gore & Associates, Inc. Dispositivo tubular de cierre de foramen oval permeable (FOP) con sistema de retención
US8480706B2 (en) 2003-07-14 2013-07-09 W.L. Gore & Associates, Inc. Tubular patent foramen ovale (PFO) closure device with catch system
US9861346B2 (en) 2003-07-14 2018-01-09 W. L. Gore & Associates, Inc. Patent foramen ovale (PFO) closure device with linearly elongating petals
US20050015110A1 (en) 2003-07-18 2005-01-20 Fogarty Thomas J. Embolization device and a method of using the same
US7533671B2 (en) 2003-08-08 2009-05-19 Spiration, Inc. Bronchoscopic repair of air leaks in a lung
US7735493B2 (en) * 2003-08-15 2010-06-15 Atritech, Inc. System and method for delivering a left atrial appendage containment device
DE602004017750D1 (de) 2003-08-19 2008-12-24 Nmt Medical Inc Expandierbarer Schleusenschlauch
WO2005034764A1 (en) 2003-09-12 2005-04-21 Nmt Medical, Inc. Device and methods for preventing formation of thrombi in the left atrial appendage
US7192435B2 (en) * 2003-09-18 2007-03-20 Cardia, Inc. Self centering closure device for septal occlusion
JP5074765B2 (ja) * 2003-10-09 2012-11-14 センターハート・インコーポレイテッド 組織の結紮のための装置及び方法
US20050192627A1 (en) * 2003-10-10 2005-09-01 Whisenant Brian K. Patent foramen ovale closure devices, delivery apparatus and related methods and systems
JP2007527272A (ja) * 2003-10-10 2007-09-27 コヒーレックス メディカル インコーポレイテッド 卵円孔開存（ｐｆｏ）閉鎖装置、送出装置、並びに関連する方法およびシステム
US7056286B2 (en) 2003-11-12 2006-06-06 Adrian Ravenscroft Medical device anchor and delivery system
US20050113868A1 (en) * 2003-11-20 2005-05-26 Devellian Carol A. Device, with electrospun fabric, for a percutaneous transluminal procedure, and methods thereof
EP3345577A1 (en) * 2003-12-04 2018-07-11 Boston Scientific Scimed, Inc. System for delivering a left atrail appendange containment device
US20050273119A1 (en) 2003-12-09 2005-12-08 Nmt Medical, Inc. Double spiral patent foramen ovale closure clamp
US7572228B2 (en) * 2004-01-13 2009-08-11 Remon Medical Technologies Ltd Devices for fixing a sensor in a lumen
US20110208233A1 (en) 2004-01-22 2011-08-25 Mcguckin Jr James F Device for preventing clot migration from left atrial appendage
JP2007519498A (ja) 2004-01-30 2007-07-19 エヌエムティー メディカル， インコーポレイティッド 心臓開口部の閉鎖のためのデバイス、システム、および方法
US8262694B2 (en) * 2004-01-30 2012-09-11 W.L. Gore & Associates, Inc. Devices, systems, and methods for closure of cardiac openings
US20050187568A1 (en) * 2004-02-20 2005-08-25 Klenk Alan R. Devices and methods for closing a patent foramen ovale with a coil-shaped closure device
CA2558247A1 (en) 2004-03-03 2005-10-06 Nmt Medical, Inc. Delivery/recovery system for septal occluder
US20050234540A1 (en) * 2004-03-12 2005-10-20 Nmt Medical, Inc. Dilatation systems and methods for left atrial appendage
US9039724B2 (en) * 2004-03-19 2015-05-26 Aga Medical Corporation Device for occluding vascular defects
US8747453B2 (en) * 2008-02-18 2014-06-10 Aga Medical Corporation Stent/stent graft for reinforcement of vascular abnormalities and associated method
US8398670B2 (en) 2004-03-19 2013-03-19 Aga Medical Corporation Multi-layer braided structures for occluding vascular defects and for occluding fluid flow through portions of the vasculature of the body
US8777974B2 (en) * 2004-03-19 2014-07-15 Aga Medical Corporation Multi-layer braided structures for occluding vascular defects
US8313505B2 (en) 2004-03-19 2012-11-20 Aga Medical Corporation Device for occluding vascular defects
US20050234509A1 (en) * 2004-03-30 2005-10-20 Mmt Medical, Inc. Center joints for PFO occluders
US20050234543A1 (en) * 2004-03-30 2005-10-20 Nmt Medical, Inc. Plug for use in left atrial appendage
US7806846B2 (en) * 2004-03-30 2010-10-05 Nmt Medical, Inc. Restoration of flow in LAA via tubular conduit
EP2644226B1 (en) 2004-04-08 2015-09-23 Aga Medical Corporation langed occlusion devices
US20050267524A1 (en) * 2004-04-09 2005-12-01 Nmt Medical, Inc. Split ends closure device
US8361110B2 (en) 2004-04-26 2013-01-29 W.L. Gore & Associates, Inc. Heart-shaped PFO closure device
US8801746B1 (en) 2004-05-04 2014-08-12 Covidien Lp System and method for delivering a left atrial appendage containment device
US7842053B2 (en) 2004-05-06 2010-11-30 Nmt Medical, Inc. Double coil occluder
US8308760B2 (en) 2004-05-06 2012-11-13 W.L. Gore & Associates, Inc. Delivery systems and methods for PFO closure device with two anchors
JP2007535997A (ja) 2004-05-07 2007-12-13 エヌエムティー メディカル， インコーポレイティッド 管状中隔オクルーダーの捕捉機構
US7704268B2 (en) * 2004-05-07 2010-04-27 Nmt Medical, Inc. Closure device with hinges
US20050256532A1 (en) * 2004-05-12 2005-11-17 Asha Nayak Cardiovascular defect patch device and method
US8267985B2 (en) 2005-05-25 2012-09-18 Tyco Healthcare Group Lp System and method for delivering and deploying an occluding device within a vessel
US8409219B2 (en) 2004-06-18 2013-04-02 Medtronic, Inc. Method and system for placement of electrical lead inside heart
US20060004388A1 (en) * 2004-06-18 2006-01-05 Ablatrics, Inc. System for tissue cavity closure
US7367975B2 (en) 2004-06-21 2008-05-06 Cierra, Inc. Energy based devices and methods for treatment of anatomic tissue defects
US7704267B2 (en) * 2004-08-04 2010-04-27 C. R. Bard, Inc. Non-entangling vena cava filter
CA2595809A1 (en) * 2004-08-31 2006-03-09 Cook Incorporated Device for treating an aneurysm
WO2006036837A2 (en) 2004-09-24 2006-04-06 Nmt Medical, Inc. Occluder device double securement system for delivery/recovery of such occluder device
BRPI0516955A (pt) * 2004-09-24 2008-09-30 Ingeneus Inc ensaio genÈmico
US8795315B2 (en) 2004-10-06 2014-08-05 Cook Medical Technologies Llc Emboli capturing device having a coil and method for capturing emboli
US7794473B2 (en) 2004-11-12 2010-09-14 C.R. Bard, Inc. Filter delivery system
US20060122522A1 (en) * 2004-12-03 2006-06-08 Abhi Chavan Devices and methods for positioning and anchoring implantable sensor devices
US7674238B2 (en) * 2004-12-23 2010-03-09 Boston Scientific Scimed, Inc. Methods and apparatus for emboli removal
US7722529B2 (en) * 2004-12-28 2010-05-25 Palo Alto Investors Expandable vessel harness for treating vessel aneurysms
US10390714B2 (en) 2005-01-12 2019-08-27 Remon Medical Technologies, Ltd. Devices for fixing a sensor in a lumen
DE102005003632A1 (de) 2005-01-20 2006-08-17 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Katheter für die transvaskuläre Implantation von Herzklappenprothesen
US8267954B2 (en) * 2005-02-04 2012-09-18 C. R. Bard, Inc. Vascular filter with sensing capability
US20060206198A1 (en) * 2005-03-12 2006-09-14 Churchwell Stacey D Aneurysm treatment devices and methods
US20060206199A1 (en) * 2005-03-12 2006-09-14 Churchwell Stacey D Aneurysm treatment devices
US8945169B2 (en) 2005-03-15 2015-02-03 Cook Medical Technologies Llc Embolic protection device
US8221446B2 (en) 2005-03-15 2012-07-17 Cook Medical Technologies Embolic protection device
US20060241687A1 (en) * 2005-03-16 2006-10-26 Glaser Erik N Septal occluder with pivot arms and articulating joints
US20060217760A1 (en) * 2005-03-17 2006-09-28 Widomski David R Multi-strand septal occluder
EP1868507A1 (en) 2005-03-18 2007-12-26 NMT Medical, Inc. Catch member for pfo occluder
US8372113B2 (en) * 2005-03-24 2013-02-12 W.L. Gore & Associates, Inc. Curved arm intracardiac occluder
WO2006110734A2 (en) * 2005-04-07 2006-10-19 Sentreheart, Inc. Apparatus and method for the ligation of tissue
EP1869424A4 (en) * 2005-04-11 2015-01-14 Terumo Corp METHOD AND DEVICE FOR CLOSING A LAYER WEBSECTED EFFECT
ES2401442T3 (es) 2005-04-22 2013-04-19 Rex Medical, L.P. Dispositivo de cierre para orejuela izquierda
WO2006124405A2 (en) 2005-05-12 2006-11-23 C.R. Bard Inc. Removable embolus blood clot filter
EP1883371B1 (en) 2005-05-25 2015-10-07 Covidien LP System and method for delivering and deploying and occluding device within a vessel
US8273101B2 (en) 2005-05-25 2012-09-25 Tyco Healthcare Group Lp System and method for delivering and deploying an occluding device within a vessel
US8932208B2 (en) 2005-05-26 2015-01-13 Maquet Cardiovascular Llc Apparatus and methods for performing minimally-invasive surgical procedures
US7850708B2 (en) 2005-06-20 2010-12-14 Cook Incorporated Embolic protection device having a reticulated body with staggered struts
US8109962B2 (en) 2005-06-20 2012-02-07 Cook Medical Technologies Llc Retrievable device having a reticulation portion with staggered struts
US8579936B2 (en) 2005-07-05 2013-11-12 ProMed, Inc. Centering of delivery devices with respect to a septal defect
US7771452B2 (en) 2005-07-12 2010-08-10 Cook Incorporated Embolic protection device with a filter bag that disengages from a basket
US7766934B2 (en) 2005-07-12 2010-08-03 Cook Incorporated Embolic protection device with an integral basket and bag
WO2007016349A2 (en) * 2005-07-29 2007-02-08 Cvdevices, Llc Devices and methods for percutaneous endo-ventricular reconstruction of the failing heart
US8187298B2 (en) 2005-08-04 2012-05-29 Cook Medical Technologies Llc Embolic protection device having inflatable frame
CA2616818C (en) 2005-08-09 2014-08-05 C.R. Bard, Inc. Embolus blood clot filter and delivery system
US7846179B2 (en) 2005-09-01 2010-12-07 Ovalis, Inc. Suture-based systems and methods for treating septal defects
WO2007030433A2 (en) 2005-09-06 2007-03-15 Nmt Medical, Inc. Removable intracardiac rf device
US9259267B2 (en) 2005-09-06 2016-02-16 W.L. Gore & Associates, Inc. Devices and methods for treating cardiac tissue
US8377092B2 (en) 2005-09-16 2013-02-19 Cook Medical Technologies Llc Embolic protection device
US7972359B2 (en) 2005-09-16 2011-07-05 Atritech, Inc. Intracardiac cage and method of delivering same
US20070088388A1 (en) * 2005-09-19 2007-04-19 Opolski Steven W Delivery device for implant with dual attachment sites
US8632562B2 (en) 2005-10-03 2014-01-21 Cook Medical Technologies Llc Embolic protection device
US8182508B2 (en) 2005-10-04 2012-05-22 Cook Medical Technologies Llc Embolic protection device
US7811251B2 (en) * 2005-10-13 2010-10-12 Tyco Healthcare Group Lp Trocar anchor
US8252017B2 (en) 2005-10-18 2012-08-28 Cook Medical Technologies Llc Invertible filter for embolic protection
CN103230290A (zh) * 2005-10-19 2013-08-07 帕尔萨脉管公司 用于脉管内夹持并修补内腔和组织缺陷的方法和系统
JP2009512521A (ja) * 2005-10-24 2009-03-26 エヌエムティー メディカル， インコーポレイティッド 放射線不透過性生体吸収性オクルダ
US8216269B2 (en) 2005-11-02 2012-07-10 Cook Medical Technologies Llc Embolic protection device having reduced profile
WO2007055654A1 (en) * 2005-11-09 2007-05-18 Merlin Md Pte Ltd Medical device with non-circumferential surface portion
CA2881760C (en) 2005-11-10 2017-06-13 Arshad Quadri Balloon-expandable, self-expanding, vascular prosthesis connecting stent
DE102005053957A1 (de) * 2005-11-11 2007-05-16 Occlutech Gmbh Occlusionsinstrument zum Verschließen eines Herzohres und Verfahren zur Herstellung eines solchen Occlusionsinstruments
US8152831B2 (en) 2005-11-17 2012-04-10 Cook Medical Technologies Llc Foam embolic protection device
US20070112372A1 (en) * 2005-11-17 2007-05-17 Stephen Sosnowski Biodegradable vascular filter
CA2940038C (en) 2005-11-18 2018-08-28 C.R. Bard, Inc. Vena cava filter with filament
US20070135826A1 (en) * 2005-12-01 2007-06-14 Steve Zaver Method and apparatus for delivering an implant without bias to a left atrial appendage
US8052715B2 (en) * 2005-12-01 2011-11-08 Atritech, Inc. Method and apparatus for recapturing an implant from the left atrial appendage
US9034006B2 (en) * 2005-12-01 2015-05-19 Atritech, Inc. Method and apparatus for retrieving an embolized implant
US20070148243A1 (en) * 2005-12-22 2007-06-28 Bates Brian L Containment of a treatment agent in a body vessel
WO2007073566A1 (en) 2005-12-22 2007-06-28 Nmt Medical, Inc. Catch members for occluder devices
US8060214B2 (en) * 2006-01-05 2011-11-15 Cardiac Pacemakers, Inc. Implantable medical device with inductive coil configurable for mechanical fixation
US8551135B2 (en) * 2006-03-31 2013-10-08 W.L. Gore & Associates, Inc. Screw catch mechanism for PFO occluder and method of use
EP2004068B1 (en) * 2006-03-31 2018-08-15 W.L. Gore & Associates, Inc. Deformable flap catch mechanism for occluder device
US7691151B2 (en) 2006-03-31 2010-04-06 Spiration, Inc. Articulable Anchor
US8870913B2 (en) 2006-03-31 2014-10-28 W.L. Gore & Associates, Inc. Catch system with locking cap for patent foramen ovale (PFO) occluder
US20070244494A1 (en) * 2006-04-18 2007-10-18 Downing Stephen W Methods and devices for treating atrial septal defects
US10188496B2 (en) 2006-05-02 2019-01-29 C. R. Bard, Inc. Vena cava filter formed from a sheet
JP5148598B2 (ja) 2006-05-03 2013-02-20 ラプトール リッジ， エルエルシー 組織閉鎖のシステムおよび方法
US20070288083A1 (en) * 2006-05-12 2007-12-13 Hines Richard A Exclusion Device and System For Delivery
WO2007143602A2 (en) 2006-06-05 2007-12-13 C.R. Bard Inc. Embolus blood clot filter utilizable with a single delivery system or a single retrieval system in one of a femoral or jugular access
US8333000B2 (en) 2006-06-19 2012-12-18 Advanced Cardiovascular Systems, Inc. Methods for improving stent retention on a balloon catheter
JP5269779B2 (ja) * 2006-06-21 2013-08-21 クック・バイオテック・インコーポレーテッド 胃腸瘻の治療に有用な瘻グラフト及び関連する方法とシステム
CA2594239A1 (en) * 2006-08-02 2008-02-02 Tyco Healthcare Group Lp Stabilization assist device for trocar
EP2056747A2 (en) * 2006-08-17 2009-05-13 NFOCUS Neuromedical Inc. Isolation devices for the treatment of aneurysms
WO2008027293A2 (en) * 2006-08-25 2008-03-06 Emphasys Medical, Inc. Bronchial isolation devices for placement in short lumens
US8676349B2 (en) 2006-09-15 2014-03-18 Cardiac Pacemakers, Inc. Mechanism for releasably engaging an implantable medical device for implantation
WO2008034077A2 (en) * 2006-09-15 2008-03-20 Cardiac Pacemakers, Inc. Anchor for an implantable sensor
US20080071307A1 (en) 2006-09-19 2008-03-20 Cook Incorporated Apparatus and methods for in situ embolic protection
US20080177301A1 (en) * 2006-10-02 2008-07-24 The Cleveland Clinic Foundation Apparatus and method for anchoring a prosthetic structure to a body tissue
US8029556B2 (en) 2006-10-04 2011-10-04 Edwards Lifesciences Corporation Method and apparatus for reshaping a ventricle
US20100152828A1 (en) * 2006-11-02 2010-06-17 Pakbaz R Sean Devices and methods for accessing and treating an aneurysm
US20080108904A1 (en) * 2006-11-08 2008-05-08 Cardiac Pacemakers, Inc. Implant for securing a sensor in a vessel
WO2008063455A1 (en) * 2006-11-13 2008-05-29 Hines Richard A Over-the wire exclusion device and system for delivery
US20080161825A1 (en) * 2006-11-20 2008-07-03 Stout Medical Group, L.P. Anatomical measurement tool
US8187315B1 (en) 2006-12-08 2012-05-29 Cardica, Inc. Partial stent for treatment of a vascular aneurysm
US11166703B2 (en) 2007-01-23 2021-11-09 Cvdevices, Llc Devices, systems, and methods for atrial appendage occlusion using light cure
WO2008091612A2 (en) 2007-01-23 2008-07-31 Cvdevices, Llc. Devices, systems, and methods for percutaneous trans-septal left atrial appendage occlusi0n
US8784469B2 (en) 2011-06-30 2014-07-22 Ghassan S. Kassab Devices, systems, and methods for inverting and closing the left atrial appendage
WO2009094237A1 (en) * 2008-01-23 2009-07-30 Cvdevices, Llc Devices, systems and methods for percutaneous trans-septal left atrial appendage occlusion
US20090319020A1 (en) * 2007-01-23 2009-12-24 Dtherapeutics, Llc Devices, systems, and methods for promoting endothelialization
US8617205B2 (en) 2007-02-01 2013-12-31 Cook Medical Technologies Llc Closure device
WO2008094706A2 (en) 2007-02-01 2008-08-07 Cook Incorporated Closure device and method of closing a bodily opening
US9901434B2 (en) 2007-02-27 2018-02-27 Cook Medical Technologies Llc Embolic protection device including a Z-stent waist band
US20080228200A1 (en) * 2007-03-16 2008-09-18 Clinton Baird Closure and reconstruction implants and the apparatus for delivery thereof
EP2929842B1 (en) 2007-03-30 2019-06-12 Sentreheart, Inc. Devices and sytems for closing the left atrial appendage
WO2008124603A1 (en) 2007-04-05 2008-10-16 Nmt Medical, Inc. Septal closure device with centering mechanism
US7896915B2 (en) 2007-04-13 2011-03-01 Jenavalve Technology, Inc. Medical device for treating a heart valve insufficiency
US9138562B2 (en) 2007-04-18 2015-09-22 W.L. Gore & Associates, Inc. Flexible catheter system
US8204599B2 (en) * 2007-05-02 2012-06-19 Cardiac Pacemakers, Inc. System for anchoring an implantable sensor in a vessel
US20080283066A1 (en) * 2007-05-17 2008-11-20 Cardiac Pacemakers, Inc. Delivery device for implantable sensors
US7992565B2 (en) * 2007-05-31 2011-08-09 Rex Medical, L.P. Fallopian tube occlusion device
JP2010527742A (ja) * 2007-05-31 2010-08-19 レックス メディカル リミテッド パートナーシップ 左心耳用閉鎖体デバイス
US20110022149A1 (en) 2007-06-04 2011-01-27 Cox Brian J Methods and devices for treatment of vascular defects
AU2008266678B2 (en) 2007-06-14 2013-06-20 Cardiac Pacemakers, Inc. Multi-element acoustic recharging system
CA2704920C (en) 2007-06-25 2016-08-16 Microvention, Inc. Self-expanding prosthesis
EP2178447B1 (en) * 2007-07-18 2017-10-25 Boston Scientific Scimed, Inc. Endoscopic implant system and method
US8419748B2 (en) 2007-09-14 2013-04-16 Cook Medical Technologies Llc Helical thrombus removal device
US9138307B2 (en) 2007-09-14 2015-09-22 Cook Medical Technologies Llc Expandable device for treatment of a stricture in a body vessel
US8252018B2 (en) 2007-09-14 2012-08-28 Cook Medical Technologies Llc Helical embolic protection device
EP2209517A4 (en) 2007-10-05 2011-03-30 Maquet Cardiovascular Llc DEVICES AND METHODS FOR MINIMALLY INVASIVE SURGICAL PROCEDURES
WO2009052432A2 (en) 2007-10-19 2009-04-23 Coherex Medical, Inc. Medical device for modification of left atrial appendange and related systems and methods
CN101945624A (zh) * 2007-12-11 2011-01-12 康奈尔大学 封闭体腔侧壁中的开口的方法和装置
US20090171386A1 (en) * 2007-12-28 2009-07-02 Aga Medical Corporation Percutaneous catheter directed intravascular occlusion devices
US9044318B2 (en) 2008-02-26 2015-06-02 Jenavalve Technology Gmbh Stent for the positioning and anchoring of a valvular prosthesis
BR112012021347A2 (pt) 2008-02-26 2019-09-24 Jenavalve Tecnology Inc stent para posicionamento e ancoragem de uma prótese valvular em um local de implantação no coração de um paciente
US20130165967A1 (en) 2008-03-07 2013-06-27 W.L. Gore & Associates, Inc. Heart occlusion devices
WO2009124144A1 (en) * 2008-04-04 2009-10-08 Curaseal Inc. Implantable fistula closure device
US20100256661A1 (en) * 2009-04-06 2010-10-07 Zeev Brandeis Apparatus and method for enabling perforating vein ablation
EP2633823B1 (en) 2008-04-21 2016-06-01 Covidien LP Braid-ball embolic devices and delivery systems
EP2279023B1 (en) 2008-05-02 2020-12-02 Sequent Medical, Inc. Filamentary devices for treatment of vascular defects
US9675482B2 (en) 2008-05-13 2017-06-13 Covidien Lp Braid implant delivery systems
US20110178539A1 (en) * 2008-07-11 2011-07-21 Holmes Jr David R Left atrial appendage occlusion devices
WO2010008936A1 (en) * 2008-07-15 2010-01-21 Cardiac Pacemakers, Inc. Implant assist apparatus for acoustically enabled implantable medical device
CN102137626A (zh) 2008-07-22 2011-07-27 微治疗公司 脉管重塑装置
AU2009289474B2 (en) * 2008-09-04 2015-09-03 Curaseal Inc. Inflatable devices for enteric fistula treatment
US8262692B2 (en) * 2008-09-05 2012-09-11 Merlin Md Pte Ltd Endovascular device
WO2010037141A1 (en) 2008-09-29 2010-04-01 Cardiaq Valve Technologies, Inc. Heart valve
US8337541B2 (en) 2008-10-01 2012-12-25 Cardiaq Valve Technologies, Inc. Delivery system for vascular implant
US10695126B2 (en) 2008-10-06 2020-06-30 Santa Anna Tech Llc Catheter with a double balloon structure to generate and apply a heated ablative zone to tissue
US8343088B2 (en) * 2008-10-21 2013-01-01 Douglas Bates Apparatus and method for treating occluded infection collections of the digestive tract
EP2196174B1 (en) 2008-12-12 2014-02-26 Abbott Laboratories Vascular Enterprises Limited Process for loading a stent onto a stent delivery system
US8388644B2 (en) 2008-12-29 2013-03-05 Cook Medical Technologies Llc Embolic protection device and method of use
US8840641B2 (en) * 2009-01-08 2014-09-23 Coherex Medical, Inc. Medical device for modification of left atrial appendage and related systems and methods
EP2389141B1 (en) * 2009-01-22 2018-12-26 Cornell University Apparatus for restricting flow through the wall of a lumen
US20100274227A1 (en) * 2009-02-13 2010-10-28 Alexander Khairkhahan Delivery catheter handle cover
US8694129B2 (en) 2009-02-13 2014-04-08 Cardiac Pacemakers, Inc. Deployable sensor platform on the lead system of an implantable device
EP3488797B1 (en) * 2009-04-01 2021-06-23 Sentreheart, Inc. Tissue ligation devices and controls therefor
NZ595417A (en) 2009-04-09 2013-10-25 Cardivascular Systems Tissue closure devices, device and systems for delivery, kits and methods therefor
EP2810620B1 (en) 2009-04-15 2022-09-14 Edwards Lifesciences CardiAQ LLC Vascular implant and delivery system
EP2442728B1 (en) 2009-06-17 2018-07-25 Coherex Medical, Inc. Medical device for modification of left atrial appendage
US10631969B2 (en) 2009-06-17 2020-04-28 Coherex Medical, Inc. Medical device for modification of left atrial appendage and related systems and methods
US9351716B2 (en) 2009-06-17 2016-05-31 Coherex Medical, Inc. Medical device and delivery system for modification of left atrial appendage and methods thereof
US10064628B2 (en) 2009-06-17 2018-09-04 Coherex Medical, Inc. Medical device for modification of left atrial appendage and related systems and methods
US9649115B2 (en) 2009-06-17 2017-05-16 Coherex Medical, Inc. Medical device for modification of left atrial appendage and related systems and methods
US9636094B2 (en) 2009-06-22 2017-05-02 W. L. Gore & Associates, Inc. Sealing device and delivery system
US20120029556A1 (en) 2009-06-22 2012-02-02 Masters Steven J Sealing device and delivery system
CA2769208C (en) 2009-07-29 2017-10-31 C.R. Bard, Inc. Tubular filter
US20110082495A1 (en) 2009-10-02 2011-04-07 Ruiz Carlos E Apparatus And Methods For Excluding The Left Atrial Appendage
AU2010315535A1 (en) 2009-10-26 2012-05-03 Cardiokinetix, Inc. Ventricular volume reduction
US20110106234A1 (en) * 2009-10-30 2011-05-05 Axel Grandt Interluminal medical treatment devices and methods
US10092427B2 (en) 2009-11-04 2018-10-09 Confluent Medical Technologies, Inc. Alternating circumferential bridge stent design and methods for use thereof
US9649211B2 (en) 2009-11-04 2017-05-16 Confluent Medical Technologies, Inc. Alternating circumferential bridge stent design and methods for use thereof
CA2778639A1 (en) * 2009-11-05 2011-05-12 Sequent Medical Inc. Multiple layer filamentary devices or treatment of vascular defects
US20110202085A1 (en) * 2009-11-09 2011-08-18 Siddharth Loganathan Braid Ball Embolic Device Features
US9539081B2 (en) 2009-12-02 2017-01-10 Surefire Medical, Inc. Method of operating a microvalve protection device
US8696698B2 (en) 2009-12-02 2014-04-15 Surefire Medical, Inc. Microvalve protection device and method of use for protection against embolization agent reflux
US8500775B2 (en) * 2009-12-02 2013-08-06 Surefire Medical, Inc. Protection device and method against embolization agent reflux
US9211123B2 (en) 2009-12-31 2015-12-15 Cook Medical Technologies Llc Intraluminal occlusion devices and methods of blocking the entry of fluid into bodily passages
EP2528541B1 (en) * 2010-01-28 2016-05-18 Covidien LP Vascular remodeling device
WO2011094638A1 (en) 2010-01-28 2011-08-04 Micro Therapeutics, Inc. Vascular remodeling device
US8500776B2 (en) * 2010-02-08 2013-08-06 Covidien Lp Vacuum patch for rapid wound closure
US20110224495A1 (en) * 2010-03-12 2011-09-15 Tyco Healthcare Group Lp Surgical access port
WO2011129893A1 (en) * 2010-04-13 2011-10-20 Sentreheart, Inc. Methods and devices for treating atrial fibrillation
US8579964B2 (en) 2010-05-05 2013-11-12 Neovasc Inc. Transcatheter mitral valve prosthesis
BR112012029896A2 (pt) 2010-05-25 2017-06-20 Jenavalve Tech Inc válcula cardíaca protética para endoprótese e endoprótese
EP3354210B1 (en) 2010-09-10 2022-10-26 Covidien LP Devices for the treatment of vascular defects
US8998947B2 (en) 2010-09-10 2015-04-07 Medina Medical, Inc. Devices and methods for the treatment of vascular defects
WO2012051489A2 (en) 2010-10-15 2012-04-19 Cook Medical Technologies Llc Occlusion device for blocking fluid flow through bodily passages
US9770319B2 (en) 2010-12-01 2017-09-26 Surefire Medical, Inc. Closed tip dynamic microvalve protection device
EP2648658B1 (en) 2010-12-06 2018-10-24 Covidien LP Vascular remodeling device
WO2012109297A2 (en) * 2011-02-10 2012-08-16 Atrial Innovations, Inc. Atrial appendage occlusion and arrhythmia treatment
CA2825774C (en) 2011-02-11 2017-02-28 Frank P. Becking Two-stage deployment aneurysm embolization devices
WO2012134990A1 (en) 2011-03-25 2012-10-04 Tyco Healthcare Group Lp Vascular remodeling device
EP2693981A4 (en) 2011-04-01 2015-07-01 Univ Cornell METHOD AND DEVICE FOR LIMITING THE RIVER THROUGH AN OPENING IN THE SIDE WALL OF A BODY LUMEN AND / OR FOR REINFORCING A WEAKNESS IN THE SIDE WALL OF A BODY LUMEN WITH AT THE SAME TIME MAINTAINING AN ESSENTIALLY NORMAL RIVER THROUGH THE BODY LUMEN
US9744033B2 (en) 2011-04-01 2017-08-29 W.L. Gore & Associates, Inc. Elastomeric leaflet for prosthetic heart valves
US9308087B2 (en) 2011-04-28 2016-04-12 Neovasc Tiara Inc. Sequentially deployed transcatheter mitral valve prosthesis
US9554897B2 (en) 2011-04-28 2017-01-31 Neovasc Tiara Inc. Methods and apparatus for engaging a valve prosthesis with tissue
US10058330B2 (en) 2011-05-11 2018-08-28 Microvention, Inc. Device for occluding a lumen
EP2717791B1 (en) 2011-06-08 2018-05-09 Sentreheart, Inc. Tissue ligation devices and tensioning devices therefor
US10117765B2 (en) 2011-06-14 2018-11-06 W.L. Gore Associates, Inc Apposition fiber for use in endoluminal deployment of expandable implants
JP6122424B2 (ja) 2011-06-16 2017-04-26 キュラシール インコーポレイテッド 瘻孔処置用デバイス及びその関連方法
US8764793B2 (en) * 2011-06-17 2014-07-01 Northwestern University Left atrial appendage occluder
IL218737A0 (en) 2012-03-19 2012-07-31 Tel Hashomer Medical Res Infrastructure & Services Ltd Body part repositioning apparatus and method
EP2731493B1 (en) * 2011-07-11 2015-07-01 The Regents of The University of Michigan Multimodality left atrial appendage occlusion device
US10314594B2 (en) 2012-12-14 2019-06-11 Corquest Medical, Inc. Assembly and method for left atrial appendage occlusion
US10307167B2 (en) 2012-12-14 2019-06-04 Corquest Medical, Inc. Assembly and method for left atrial appendage occlusion
US10813630B2 (en) 2011-08-09 2020-10-27 Corquest Medical, Inc. Closure system for atrial wall
US9770232B2 (en) 2011-08-12 2017-09-26 W. L. Gore & Associates, Inc. Heart occlusion devices
US9011468B2 (en) 2011-09-13 2015-04-21 Abbott Cardiovascular Systems Inc. Independent gripper
US8945177B2 (en) 2011-09-13 2015-02-03 Abbott Cardiovascular Systems Inc. Gripper pusher mechanism for tissue apposition systems
US9554806B2 (en) 2011-09-16 2017-01-31 W. L. Gore & Associates, Inc. Occlusive devices
US9089668B2 (en) 2011-09-28 2015-07-28 Surefire Medical, Inc. Flow directional infusion device
US9060886B2 (en) 2011-09-29 2015-06-23 Covidien Lp Vascular remodeling device
WO2013055703A1 (en) 2011-10-07 2013-04-18 Cornell University Method and apparatus for restricting flow through an opening in a body lumen while maintaining normal flow
EP3682813B1 (en) 2011-11-01 2023-12-27 Coherex Medical, Inc. Medical device for modification of left atrial appendage
WO2013071115A1 (en) 2011-11-09 2013-05-16 Boston Scientific Scimed, Inc. Occlusion device
US9782282B2 (en) 2011-11-14 2017-10-10 W. L. Gore & Associates, Inc. External steerable fiber for use in endoluminal deployment of expandable devices
US9877858B2 (en) 2011-11-14 2018-01-30 W. L. Gore & Associates, Inc. External steerable fiber for use in endoluminal deployment of expandable devices
JP2013154089A (ja) 2012-01-31 2013-08-15 Terumo Corp 瘤治療デバイス及び瘤治療方法
US10940167B2 (en) 2012-02-10 2021-03-09 Cvdevices, Llc Methods and uses of biological tissues for various stent and other medical applications
US9089341B2 (en) 2012-02-28 2015-07-28 Surefire Medical, Inc. Renal nerve neuromodulation device
US20130237908A1 (en) * 2012-03-09 2013-09-12 Boston Scientific Scimed, Inc. Sponge-like left atrial occlusion device and related methods of use
US9375308B2 (en) 2012-03-13 2016-06-28 W. L. Gore & Associates, Inc. External steerable fiber for use in endoluminal deployment of expandable devices
US9345573B2 (en) 2012-05-30 2016-05-24 Neovasc Tiara Inc. Methods and apparatus for loading a prosthesis onto a delivery system
WO2014111911A1 (en) 2013-01-18 2014-07-24 Javelin Medical Ltd. Monofilament implants and systems for delivery thereof
ES2891099T3 (es) 2012-05-31 2022-01-26 Javelin Medical Ltd Dispositivos de protección embólica
US9155647B2 (en) 2012-07-18 2015-10-13 Covidien Lp Methods and apparatus for luminal stenting
EP2877104A4 (en) 2012-07-26 2016-03-30 Univ Louisville Res Found ATRIAL APPENDIX CLOSURE DEVICE AND ASSOCIATED METHODS
US9186267B2 (en) 2012-10-31 2015-11-17 Covidien Lp Wing bifurcation reconstruction device
US9314248B2 (en) 2012-11-06 2016-04-19 Covidien Lp Multi-pivot thrombectomy device
US9295393B2 (en) 2012-11-09 2016-03-29 Elwha Llc Embolism deflector
US20140135810A1 (en) 2012-11-13 2014-05-15 Covidien Lp Occlusive devices
US20140142689A1 (en) 2012-11-21 2014-05-22 Didier De Canniere Device and method of treating heart valve malfunction
US9011481B2 (en) 2012-12-30 2015-04-21 Cook Medical Technologies Llc Vascular occlusion device having a jelly fish
US9295571B2 (en) 2013-01-17 2016-03-29 Covidien Lp Methods and apparatus for luminal stenting
US10828019B2 (en) 2013-01-18 2020-11-10 W.L. Gore & Associates, Inc. Sealing device and delivery system
WO2014124356A2 (en) 2013-02-11 2014-08-14 Cook Medical Technologies Llc Expandable support frame and medical device
US10583002B2 (en) 2013-03-11 2020-03-10 Neovasc Tiara Inc. Prosthetic valve with anti-pivoting mechanism
EP2967534B1 (en) 2013-03-12 2018-04-25 Sentreheart, Inc. Tissue ligation devices
EP2968873A4 (en) 2013-03-13 2016-10-26 Applied Cardiovascular Solutions Llc METHODS, COMPOSITIONS AND DEVICES FOR OCCLUSION OF CAVITIES AND PASSAGES
US10617425B2 (en) 2014-03-10 2020-04-14 Conformal Medical, Inc. Devices and methods for excluding the left atrial appendage
US11399842B2 (en) 2013-03-13 2022-08-02 Conformal Medical, Inc. Devices and methods for excluding the left atrial appendage
EP2968878B1 (en) 2013-03-13 2020-08-12 Conformal Medical, Inc. Devices for excluding the left atrial appendage
US9730791B2 (en) 2013-03-14 2017-08-15 Edwards Lifesciences Cardiaq Llc Prosthesis for atraumatically grasping intralumenal tissue and methods of delivery
US9681951B2 (en) 2013-03-14 2017-06-20 Edwards Lifesciences Cardiaq Llc Prosthesis with outer skirt and anchors
US9463105B2 (en) 2013-03-14 2016-10-11 Covidien Lp Methods and apparatus for luminal stenting
US10736758B2 (en) 2013-03-15 2020-08-11 Covidien Occlusive device
US9572665B2 (en) 2013-04-04 2017-02-21 Neovasc Tiara Inc. Methods and apparatus for delivering a prosthetic valve to a beating heart
US9592399B2 (en) 2013-06-20 2017-03-14 Cardiac Pacemakers, Inc. Deployable multi-electrode leadless electrostimulator
US11911258B2 (en) 2013-06-26 2024-02-27 W. L. Gore & Associates, Inc. Space filling devices
US9955976B2 (en) 2013-08-16 2018-05-01 Sequent Medical, Inc. Filamentary devices for treatment of vascular defects
US9078658B2 (en) 2013-08-16 2015-07-14 Sequent Medical, Inc. Filamentary devices for treatment of vascular defects
JP6563394B2 (ja) 2013-08-30 2019-08-21 イェーナヴァルヴ テクノロジー インコーポレイテッド 人工弁のための径方向に折り畳み自在のフレーム及び当該フレームを製造するための方法
EP4226881A1 (en) 2013-10-31 2023-08-16 AtriCure, Inc. Device for left atrial appendage closure
US10485545B2 (en) 2013-11-19 2019-11-26 Datascope Corp. Fastener applicator with interlock
US9566443B2 (en) 2013-11-26 2017-02-14 Corquest Medical, Inc. System for treating heart valve malfunction including mitral regurgitation
US9592110B1 (en) 2013-12-06 2017-03-14 Javelin Medical, Ltd. Systems and methods for implant delivery
US9889031B1 (en) 2014-03-25 2018-02-13 Surefire Medical, Inc. Method of gastric artery embolization
US9968740B2 (en) 2014-03-25 2018-05-15 Surefire Medical, Inc. Closed tip dynamic microvalve protection device
US11154302B2 (en) 2014-03-31 2021-10-26 DePuy Synthes Products, Inc. Aneurysm occlusion device
US11076860B2 (en) 2014-03-31 2021-08-03 DePuy Synthes Products, Inc. Aneurysm occlusion device
US9629635B2 (en) 2014-04-14 2017-04-25 Sequent Medical, Inc. Devices for therapeutic vascular procedures
AU2015249283B2 (en) * 2014-04-25 2019-07-18 Flow Medtech, Llc Left atrial appendage occlusion device
ES2905419T3 (es) 2014-04-30 2022-04-08 Cerus Endovascular Ltd Dispositivo de oclusión
US9808230B2 (en) 2014-06-06 2017-11-07 W. L. Gore & Associates, Inc. Sealing device and delivery system
CN104107072A (zh) * 2014-07-29 2014-10-22 孙伟 双伞式左心耳封闭装置
CN105476683A (zh) * 2014-09-16 2016-04-13 徐州亚太科技有限公司 一种组合式左心耳封堵器
EP3193790A4 (en) 2014-09-19 2018-10-03 Flow Medtech, Inc. Left atrial appendage occlusion device delivery system
WO2016048802A1 (en) 2014-09-28 2016-03-31 Cardiokinetix, Inc. Apparatuses for treating cardiac dysfunction
US10842626B2 (en) 2014-12-09 2020-11-24 Didier De Canniere Intracardiac device to correct mitral regurgitation
US10188392B2 (en) 2014-12-19 2019-01-29 Abbott Cardiovascular Systems, Inc. Grasping for tissue repair
GB201511595D0 (en) * 2014-12-23 2015-08-19 Whiteley Mark Medical device for treating a vein
CN105796148B (zh) * 2014-12-31 2018-06-05 先健科技(深圳)有限公司 左心耳封堵器
US9375333B1 (en) 2015-03-06 2016-06-28 Covidien Lp Implantable device detachment systems and associated devices and methods
EP3273866B1 (en) 2015-03-24 2023-12-13 AtriCure, Inc. Devices for left atrial appendage closure
EP4285843A2 (en) 2015-03-24 2023-12-06 AtriCure, Inc. Tissue ligation devices
US20160287839A1 (en) 2015-03-31 2016-10-06 Surefire Medical, Inc. Apparatus and Method for Infusing an Immunotherapy Agent to a Solid Tumor for Treatment
US10524912B2 (en) 2015-04-02 2020-01-07 Abbott Cardiovascular Systems, Inc. Tissue fixation devices and methods
EP3288495B1 (en) 2015-05-01 2019-09-25 JenaValve Technology, Inc. Device with reduced pacemaker rate in heart valve replacement
US9757574B2 (en) 2015-05-11 2017-09-12 Rainbow Medical Ltd. Dual chamber transvenous pacemaker
JP2018515246A (ja) 2015-05-14 2018-06-14 ダブリュ．エル．ゴア アンド アソシエイツ，インコーポレイティドＷ．Ｌ． Ｇｏｒｅ ＆ Ａｓｓｏｃｉａｔｅｓ， Ｉｎｃｏｒｐｏｒａｔｅｄ 心耳の閉塞のためのデバイスおよび方法
WO2016185440A1 (en) 2015-05-21 2016-11-24 Ecole Polytechnique Federale De Lausanne (Epfl) Device and method for injection, photoactivation and solidifaction of liquid embolic material in the vascular system or other organic cavities
US20170035433A1 (en) * 2015-08-06 2017-02-09 Thomas J. Forbes Left atrial appendage occluder device anchoring system, anchor, and method of attachment
EP3340890B1 (en) * 2015-08-25 2022-07-06 University Of Louisville Research Foundation, Inc. Atrial appendage closure device
US10478194B2 (en) 2015-09-23 2019-11-19 Covidien Lp Occlusive devices
US10667896B2 (en) 2015-11-13 2020-06-02 Cardiac Pacemakers, Inc. Bioabsorbable left atrial appendage closure with endothelialization promoting surface
CA3005686A1 (en) 2015-12-07 2017-06-15 Cerus Endovascular Limited Occlusion device
CN108882949B (zh) 2016-02-26 2021-11-09 森特里心脏股份有限公司 用于左心耳闭合的装置和方法
US10327809B2 (en) 2016-02-29 2019-06-25 Covidien Lp Clip collar advanced fixation
CN113171150A (zh) 2016-03-11 2021-07-27 Cerus血管内设备有限公司 封堵装置
WO2017195125A1 (en) 2016-05-13 2017-11-16 Jenavalve Technology, Inc. Heart valve prosthesis delivery system and method for delivery of heart valve prosthesis with introducer sheath and loading system
US11331140B2 (en) 2016-05-19 2022-05-17 Aqua Heart, Inc. Heated vapor ablation systems and methods for treating cardiac conditions
US10478195B2 (en) 2016-08-04 2019-11-19 Covidien Lp Devices, systems, and methods for the treatment of vascular defects
US10780250B1 (en) 2016-09-19 2020-09-22 Surefire Medical, Inc. System and method for selective pressure-controlled therapeutic delivery
US11400263B1 (en) 2016-09-19 2022-08-02 Trisalus Life Sciences, Inc. System and method for selective pressure-controlled therapeutic delivery
EP4331536A2 (en) 2016-10-21 2024-03-06 Javelin Medical Ltd. Systems, methods and devices for embolic protection
US11426172B2 (en) 2016-10-27 2022-08-30 Conformal Medical, Inc. Devices and methods for excluding the left atrial appendage
JP7071350B2 (ja) 2016-10-27 2022-05-18 コンフォーマル・メディカル・インコーポレイテッド 左心耳を排除するためのデバイスおよび方法
US10583301B2 (en) 2016-11-08 2020-03-10 Cardiac Pacemakers, Inc. Implantable medical device for atrial deployment
JP7094965B2 (ja) 2017-01-27 2022-07-04 イエナバルブ テクノロジー インク 心臓弁模倣
US10751066B2 (en) 2017-02-23 2020-08-25 DePuy Synthes Products, Inc. Aneurysm device and delivery system
US10588636B2 (en) 2017-03-20 2020-03-17 Surefire Medical, Inc. Dynamic reconfigurable microvalve protection device
EP3600079A1 (en) 2017-03-27 2020-02-05 Append Medical Ltd. Left atrial appendage closure
DE102018107407A1 (de) 2017-03-28 2018-10-04 Edwards Lifesciences Corporation Positionieren, einsetzen und zurückholen von implantierbaren vorrichtungen
WO2018200891A1 (en) 2017-04-27 2018-11-01 Boston Scientific Scimed, Inc. Occlusive medical device with fabric retention barb
US11357512B2 (en) * 2017-05-12 2022-06-14 Robert Fishel Mechanism and device for left atrial appendage occlusion with electrical isolation
US10542996B2 (en) 2017-06-27 2020-01-28 Covidien Lp Vessel closure device
MX2020001999A (es) 2017-08-21 2020-07-20 Cerus Endovascular Ltd Dispositivo de oclusion.
US10675036B2 (en) 2017-08-22 2020-06-09 Covidien Lp Devices, systems, and methods for the treatment of vascular defects
EP3459469A1 (en) 2017-09-23 2019-03-27 Universität Zürich Medical occluder device
US11173023B2 (en) 2017-10-16 2021-11-16 W. L. Gore & Associates, Inc. Medical devices and anchors therefor
CN111417432A (zh) 2017-12-01 2020-07-14 心脏起搏器股份公司 具有复归行为的无引线心脏起搏器
CN111417433A (zh) 2017-12-01 2020-07-14 心脏起搏器股份公司 从心室植入的无引线心脏起搏器检测心室充盈期间心房收缩定时基准的方法和系统
CN111432875A (zh) 2017-12-01 2020-07-17 心脏起搏器股份公司 从心室植入式无引线心脏起搏器检测心房收缩定时基准并确定心脏间隔的方法和系统
EP4338688A2 (en) 2017-12-18 2024-03-20 Boston Scientific Scimed, Inc. Occlusive device with expandable member
US11413048B2 (en) 2018-01-19 2022-08-16 Boston Scientific Scimed, Inc. Occlusive medical device with delivery system
US10905430B2 (en) 2018-01-24 2021-02-02 DePuy Synthes Products, Inc. Aneurysm device and delivery system
US11191547B2 (en) 2018-01-26 2021-12-07 Syntheon 2.0, LLC Left atrial appendage clipping device and methods for clipping the LAA
CN111867490B (zh) 2018-02-14 2024-01-30 波士顿科学医学有限公司 闭塞医疗装置
WO2019191271A1 (en) 2018-03-28 2019-10-03 Datascope Corp. Device for atrial appendage exclusion
WO2019213274A1 (en) 2018-05-02 2019-11-07 Boston Scientific Scimed, Inc. Occlusive sealing sensor system
JP7241095B2 (ja) 2018-05-15 2023-03-16 ボストン サイエンティフィック サイムド，インコーポレイテッド 帯電したポリマーコーティングを備えた閉塞性医療装置
US11058430B2 (en) 2018-05-25 2021-07-13 DePuy Synthes Products, Inc. Aneurysm device and delivery system
US11596412B2 (en) 2018-05-25 2023-03-07 DePuy Synthes Products, Inc. Aneurysm device and delivery system
US10939915B2 (en) 2018-05-31 2021-03-09 DePuy Synthes Products, Inc. Aneurysm device and delivery system
US11123079B2 (en) 2018-06-08 2021-09-21 Boston Scientific Scimed, Inc. Occlusive device with actuatable fixation members
EP3801300A1 (en) 2018-06-08 2021-04-14 Boston Scientific Scimed, Inc. Medical device with occlusive member
EP3817671A1 (en) 2018-07-06 2021-05-12 Boston Scientific Scimed Inc. Occlusive medical device
US11850398B2 (en) 2018-08-01 2023-12-26 Trisalus Life Sciences, Inc. Systems and methods for pressure-facilitated therapeutic agent delivery
US11051825B2 (en) 2018-08-08 2021-07-06 DePuy Synthes Products, Inc. Delivery system for embolic braid
EP3840670B1 (en) 2018-08-21 2023-11-15 Boston Scientific Scimed, Inc. Projecting member with barb for cardiovascular devices
US11123077B2 (en) 2018-09-25 2021-09-21 DePuy Synthes Products, Inc. Intrasaccular device positioning and deployment system
US11338117B2 (en) 2018-10-08 2022-05-24 Trisalus Life Sciences, Inc. Implantable dual pathway therapeutic agent delivery port
US11076861B2 (en) 2018-10-12 2021-08-03 DePuy Synthes Products, Inc. Folded aneurysm treatment device and delivery method
US11406392B2 (en) 2018-12-12 2022-08-09 DePuy Synthes Products, Inc. Aneurysm occluding device for use with coagulating agents
CN111491575A (zh) 2018-12-17 2020-08-04 柯惠有限合伙公司 用于治疗血管缺损的装置、系统和方法
US11272939B2 (en) 2018-12-18 2022-03-15 DePuy Synthes Products, Inc. Intrasaccular flow diverter for treating cerebral aneurysms
US20200222172A1 (en) * 2019-01-11 2020-07-16 Varun Shetty Method and system for reducing pulmonary flow
US11134953B2 (en) * 2019-02-06 2021-10-05 DePuy Synthes Products, Inc. Adhesive cover occluding device for aneurysm treatment
EP3920810A4 (en) 2019-02-08 2022-11-09 Conformal Medical, Inc. DEVICES AND METHODS FOR EXCLUSION OF THE LEFT ATRIAL APPENDIX
US20200269059A1 (en) * 2019-02-20 2020-08-27 Ablation Innovations, LLC Apparatus, systems, and methods to improve atrial fibrillation outcomes involving the left atrial appendage
WO2020190620A1 (en) 2019-03-15 2020-09-24 Sequent Medical, Inc. Filamentary devices for treatment of vascular defects
WO2020190630A1 (en) 2019-03-15 2020-09-24 Sequent Medical, Inc. Filamentary devices having a flexible joint for treatment of vascular defects
EP3908354A4 (en) 2019-03-15 2023-04-26 Sequent Medical, Inc. FIBROUS DEVICES FOR TREATMENT OF VASCULAR DEFECTS
US11337706B2 (en) 2019-03-27 2022-05-24 DePuy Synthes Products, Inc. Aneurysm treatment device
US10925615B2 (en) 2019-05-03 2021-02-23 Syntheon 2.0, LLC Recapturable left atrial appendage clipping device and methods for recapturing a left atrial appendage clip
US11607226B2 (en) 2019-05-21 2023-03-21 DePuy Synthes Products, Inc. Layered braided aneurysm treatment device with corrugations
US11413046B2 (en) 2019-05-21 2022-08-16 DePuy Synthes Products, Inc. Layered braided aneurysm treatment device
US10653425B1 (en) 2019-05-21 2020-05-19 DePuy Synthes Products, Inc. Layered braided aneurysm treatment device
US11672542B2 (en) 2019-05-21 2023-06-13 DePuy Synthes Products, Inc. Aneurysm treatment with pushable ball segment
US11602350B2 (en) 2019-12-05 2023-03-14 DePuy Synthes Products, Inc. Intrasaccular inverting braid with highly flexible fill material
US11278292B2 (en) 2019-05-21 2022-03-22 DePuy Synthes Products, Inc. Inverting braided aneurysm treatment system and method
US11497504B2 (en) 2019-05-21 2022-11-15 DePuy Synthes Products, Inc. Aneurysm treatment with pushable implanted braid
US11534303B2 (en) 2020-04-09 2022-12-27 Evalve, Inc. Devices and systems for accessing and repairing a heart valve
US11369355B2 (en) 2019-06-17 2022-06-28 Coherex Medical, Inc. Medical device and system for occluding a tissue opening and method thereof
JP2022541221A (ja) 2019-07-15 2022-09-22 エバルブ，インコーポレイティド 非変形ウィングを持つワイドクリップ
CN114302698A (zh) 2019-07-15 2022-04-08 埃瓦尔维公司 近端元件致动器的固定和释放机构
WO2021041831A1 (en) * 2019-08-30 2021-03-04 Boston Scientific Scimed, Inc. Left atrial appendage implant with sealing disk
US11707228B2 (en) 2019-09-26 2023-07-25 Evalve, Inc. Systems and methods for intra-procedural cardiac pressure monitoring
EP4041136A1 (en) 2019-10-11 2022-08-17 Evalve, Inc. Repair clip for variable tissue thickness
EP4054439A1 (en) 2019-11-04 2022-09-14 Covidien LP Systems and methods for treating aneurysms
WO2021092460A1 (en) 2019-11-08 2021-05-14 Evalve, Inc. Medical device delivery system with locking system
US11701229B2 (en) 2019-11-14 2023-07-18 Evalve, Inc. Kit with coaptation aid and fixation system and methods for valve repair
US11801140B2 (en) 2019-11-14 2023-10-31 Evalve, Inc. Catheter assembly with coaptation aid and methods for valve repair
US11457926B2 (en) 2019-12-18 2022-10-04 DePuy Synthes Products, Inc. Implant having an intrasaccular section and intravascular section
US11406404B2 (en) 2020-02-20 2022-08-09 Cerus Endovascular Limited Clot removal distal protection methods
WO2021195085A1 (en) 2020-03-24 2021-09-30 Boston Scientific Scimed, Inc. Medical system for treating a left atrial appendage
US11931041B2 (en) 2020-05-12 2024-03-19 Covidien Lp Devices, systems, and methods for the treatment of vascular defects
JP2023540220A (ja) 2020-08-25 2023-09-22 シファメド・ホールディングス・エルエルシー 調整式心房間分流器と関連のシステム及び方法
CN112022425A (zh) * 2020-09-11 2020-12-04 复旦大学附属中山医院 血栓过滤装置
EP4243915A1 (en) 2020-11-12 2023-09-20 Shifamed Holdings, LLC Adjustable implantable devices and associated methods
US11812969B2 (en) 2020-12-03 2023-11-14 Coherex Medical, Inc. Medical device and system for occluding a tissue opening and method thereof
CN117642192A (zh) * 2021-07-09 2024-03-01 波士顿科学医学有限公司 直接口服抗凝剂洗脱医疗设备

Family Cites Families (129)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US178283A (en) 1876-06-06 Improvement in vaginal syringes
US1967318A (en) 1931-10-02 1934-07-24 Monahan William Apparatus for the treatment of the urethra
US3844302A (en) 1970-09-14 1974-10-29 Telesco Brophey Ltd Collapsible umbrella
US3874388A (en) 1973-02-12 1975-04-01 Ochsner Med Found Alton Shunt defect closure system
US4007743A (en) 1975-10-20 1977-02-15 American Hospital Supply Corporation Opening mechanism for umbrella-like intravascular shunt defect closure device
US4603693A (en) 1977-05-26 1986-08-05 United States Surgical Corporation Instrument for circular surgical stapling of hollow body organs and disposable cartridge therefor
US4341218A (en) 1978-05-30 1982-07-27 University Of California Detachable balloon catheter
US4585000A (en) 1983-09-28 1986-04-29 Cordis Corporation Expandable device for treating intravascular stenosis
US4665906A (en) 1983-10-14 1987-05-19 Raychem Corporation Medical devices incorporating sim alloy elements
US4710192A (en) 1985-12-30 1987-12-01 Liotta Domingo S Diaphragm and method for occlusion of the descending thoracic aorta
US5037810A (en) * 1987-03-17 1991-08-06 Saliba Jr Michael J Medical application for heparin and related molecules
US5041090A (en) 1988-01-12 1991-08-20 Scheglov Viktor I Occluding device
US6120437A (en) 1988-07-22 2000-09-19 Inbae Yoon Methods for creating spaces at obstructed sites endoscopically and methods therefor
US4921484A (en) 1988-07-25 1990-05-01 Cordis Corporation Mesh balloon catheter device
US4917089A (en) 1988-08-29 1990-04-17 Sideris Eleftherios B Buttoned device for the transvenous occlusion of intracardiac defects
FR2641692A1 (fr) 1989-01-17 1990-07-20 Nippon Zeon Co Bouchon de fermeture d'une breche pour application medicale et dispositif pour bouchon de fermeture l'utilisant
DE8904371U1 (zh) 1989-04-07 1989-06-08 Herzberg, Wolfgang, Dr. Med., 2000 Wedel, De
NL8901350A (nl) 1989-05-29 1990-12-17 Wouter Matthijs Muijs Van De M Afsluitsamenstel.
US5421832A (en) 1989-12-13 1995-06-06 Lefebvre; Jean-Marie Filter-catheter and method of manufacturing same
US5041093A (en) 1990-01-31 1991-08-20 Boston Scientific Corp. Catheter with foraminous anchor
ATE107150T1 (de) 1990-04-02 1994-07-15 Kanji Inoue Vorrichtung zum verschliessen einer nebenschlussöffnung mittels eines nichtoperativen verfahrens.
US5078736A (en) 1990-05-04 1992-01-07 Interventional Thermodynamics, Inc. Method and apparatus for maintaining patency in the body passages
US5064435A (en) 1990-06-28 1991-11-12 Schneider (Usa) Inc. Self-expanding prosthesis having stable axial length
US5042707A (en) 1990-10-16 1991-08-27 Taheri Syde A Intravascular stapler, and method of operating same
US5108420A (en) 1991-02-01 1992-04-28 Temple University Aperture occlusion device
SE467948B (sv) 1991-06-14 1992-10-12 Ams Medinvent Sa Anordning foer transluminal uttagning eller implantation av en stent samt apparat innefattande en dylik anordning
US5735290A (en) 1993-02-22 1998-04-07 Heartport, Inc. Methods and systems for performing thoracoscopic coronary bypass and other procedures
CA2078530A1 (en) 1991-09-23 1993-03-24 Jay Erlebacher Percutaneous arterial puncture seal device and insertion tool therefore
US5256146A (en) 1991-10-11 1993-10-26 W. D. Ensminger Vascular catheterization system with catheter anchoring feature
DE69229539T2 (de) 1991-11-05 2000-02-17 Childrens Medical Center Okklusionsvorrichtung zur Reparatur von Herz- und Gefäss-Defekten
EP0541063B1 (en) 1991-11-05 1998-09-02 The Children's Medical Center Corporation Improved occluder for repair of cardiac and vascular defects
US5282827A (en) 1991-11-08 1994-02-01 Kensey Nash Corporation Hemostatic puncture closure system and method of use
US5176692A (en) 1991-12-09 1993-01-05 Wilk Peter J Method and surgical instrument for repairing hernia
US5258042A (en) 1991-12-16 1993-11-02 Henry Ford Health System Intravascular hydrogel implant
US5626605A (en) 1991-12-30 1997-05-06 Scimed Life Systems, Inc. Thrombosis filter
EP0876793B1 (en) 1992-01-21 2007-12-26 Regents Of The University Of Minnesota Septal Defect Closure Device
FR2689388B1 (fr) 1992-04-07 1999-07-16 Celsa Lg Filtre sanguin perfectionne eventuellement resorbable.
US5637097A (en) 1992-04-15 1997-06-10 Yoon; Inbae Penetrating instrument having an expandable anchoring portion
US5707362A (en) 1992-04-15 1998-01-13 Yoon; Inbae Penetrating instrument having an expandable anchoring portion for triggering protrusion of a safety member and/or retraction of a penetrating member
US5766246A (en) 1992-05-20 1998-06-16 C. R. Bard, Inc. Implantable prosthesis and method and apparatus for loading and delivering an implantable prothesis
US5527338A (en) 1992-09-02 1996-06-18 Board Of Regents, The University Of Texas System Intravascular device
US5469867A (en) 1992-09-02 1995-11-28 Landec Corporation Cast-in place thermoplastic channel occluder
FR2696092B1 (fr) 1992-09-28 1994-12-30 Lefebvre Jean Marie Kit à usage médical composé d'un filtre et de son dispositif de mise en place dans le vaisseau.
US5382259A (en) 1992-10-26 1995-01-17 Target Therapeutics, Inc. Vasoocclusion coil with attached tubular woven or braided fibrous covering
US5643317A (en) 1992-11-25 1997-07-01 William Cook Europe S.A. Closure prosthesis for transcatheter placement
US5443454A (en) 1992-12-09 1995-08-22 Terumo Kabushiki Kaisha Catheter for embolectomy
US5417699A (en) 1992-12-10 1995-05-23 Perclose Incorporated Device and method for the percutaneous suturing of a vascular puncture site
US5284488A (en) 1992-12-23 1994-02-08 Sideris Eleftherios B Adjustable devices for the occlusion of cardiac defects
US5797960A (en) 1993-02-22 1998-08-25 Stevens; John H. Method and apparatus for thoracoscopic intracardiac procedures
US6161543A (en) * 1993-02-22 2000-12-19 Epicor, Inc. Methods of epicardial ablation for creating a lesion around the pulmonary veins
US5306234A (en) 1993-03-23 1994-04-26 Johnson W Dudley Method for closing an atrial appendage
US5353784A (en) 1993-04-02 1994-10-11 The Research Foundation Of Suny Endoscopic device and method of use
US5527322A (en) 1993-11-08 1996-06-18 Perclose, Inc. Device and method for suturing of internal puncture sites
US5490856A (en) 1993-12-14 1996-02-13 Untied States Surgical Corporation Purse string stapler
US5591196A (en) 1994-02-10 1997-01-07 Endovascular Systems, Inc. Method for deployment of radially expandable stents
US5634942A (en) 1994-04-21 1997-06-03 B. Braun Celsa Assembly comprising a blood filter for temporary or definitive use and a device for implanting it
US5522836A (en) 1994-06-27 1996-06-04 Target Therapeutics, Inc. Electrolytically severable coil assembly with movable detachment point
US5725552A (en) * 1994-07-08 1998-03-10 Aga Medical Corporation Percutaneous catheter directed intravascular occlusion devices
US5846261A (en) 1994-07-08 1998-12-08 Aga Medical Corp. Percutaneous catheter directed occlusion devices
US5433727A (en) 1994-08-16 1995-07-18 Sideris; Eleftherios B. Centering buttoned device for the occlusion of large defects for occluding
JPH08196538A (ja) * 1994-09-26 1996-08-06 Ethicon Inc エラストマー部材を有する外科用の組織付着器具および該組織へ外科用のメッシュを張り付ける方法
US5690671A (en) 1994-12-13 1997-11-25 Micro Interventional Systems, Inc. Embolic elements and methods and apparatus for their delivery
US5879366A (en) 1996-12-20 1999-03-09 W.L. Gore & Associates, Inc. Self-expanding defect closure device and method of making and using
US5643292A (en) 1995-01-10 1997-07-01 Applied Medical Resources Corporation Percutaneous suturing device
US5702421A (en) 1995-01-11 1997-12-30 Schneidt; Bernhard Closure device for closing a vascular opening, such as patent ductus arteriosus
US5614204A (en) 1995-01-23 1997-03-25 The Regents Of The University Of California Angiographic vascular occlusion agents and a method for hemostatic occlusion
US5634936A (en) 1995-02-06 1997-06-03 Scimed Life Systems, Inc. Device for closing a septal defect
US5849005A (en) 1995-06-07 1998-12-15 Heartport, Inc. Method and apparatus for minimizing the risk of air embolism when performing a procedure in a patient's thoracic cavity
US5645558A (en) 1995-04-20 1997-07-08 Medical University Of South Carolina Anatomically shaped vasoocclusive device and method of making the same
US5681347A (en) 1995-05-23 1997-10-28 Boston Scientific Corporation Vena cava filter delivery system
US6132438A (en) 1995-06-07 2000-10-17 Ep Technologies, Inc. Devices for installing stasis reducing means in body tissue
US5709224A (en) 1995-06-07 1998-01-20 Radiotherapeutics Corporation Method and device for permanent vessel occlusion
US5725568A (en) 1995-06-27 1998-03-10 Scimed Life Systems, Inc. Method and device for recanalizing and grafting arteries
US5749883A (en) 1995-08-30 1998-05-12 Halpern; David Marcos Medical instrument
DE69612507T2 (de) 1995-10-30 2001-08-09 Childrens Medical Center Selbstzentrierende, schirmartige vorrichtung zum verschliessen eines septal-defektes
US5989281A (en) 1995-11-07 1999-11-23 Embol-X, Inc. Cannula with associated filter and methods of use during cardiac surgery
US5769816A (en) 1995-11-07 1998-06-23 Embol-X, Inc. Cannula with associated filter
US5749894A (en) 1996-01-18 1998-05-12 Target Therapeutics, Inc. Aneurysm closure method
NL1002423C2 (nl) 1996-02-22 1997-08-25 Cordis Europ Tijdelijk-filtercatheter.
US5885258A (en) 1996-02-23 1999-03-23 Memory Medical Systems, Inc. Medical instrument with slotted memory metal tube
US5733294A (en) 1996-02-28 1998-03-31 B. Braun Medical, Inc. Self expanding cardiovascular occlusion device, method of using and method of making the same
US6139527A (en) 1996-03-05 2000-10-31 Vnus Medical Technologies, Inc. Method and apparatus for treating hemorrhoids
US5853422A (en) 1996-03-22 1998-12-29 Scimed Life Systems, Inc. Apparatus and method for closing a septal defect
US5906207A (en) 1996-04-04 1999-05-25 Merck & Co., Inc. Method for simulating heart failure
AR001590A1 (es) 1996-04-10 1997-11-26 Jorge Alberto Baccaro Dispositivo oclusor de comunicaciones vasculares anormales y cartucho aplicador de dicho dispositivo
AU3186897A (en) 1996-05-08 1997-11-26 Salviac Limited An occluder device
US6048331A (en) 1996-05-14 2000-04-11 Embol-X, Inc. Cardioplegia occluder
US5830228A (en) 1996-05-29 1998-11-03 Urosurge, Inc. Methods and systems for deployment of a detachable balloon at a target site in vivo
US5662671A (en) 1996-07-17 1997-09-02 Embol-X, Inc. Atherectomy device having trapping and excising means for removal of plaque from the aorta and other arteries
US5669933A (en) 1996-07-17 1997-09-23 Nitinol Medical Technologies, Inc. Removable embolus blood clot filter
US5823198A (en) 1996-07-31 1998-10-20 Micro Therapeutics, Inc. Method and apparatus for intravasculer embolization
US5941249A (en) 1996-09-05 1999-08-24 Maynard; Ronald S. Distributed activator for a two-dimensional shape memory alloy
US5876367A (en) 1996-12-05 1999-03-02 Embol-X, Inc. Cerebral protection during carotid endarterectomy and downstream vascular protection during other surgeries
US5776097A (en) 1996-12-19 1998-07-07 University Of California At Los Angeles Method and device for treating intracranial vascular aneurysms
US5782860A (en) 1997-02-11 1998-07-21 Biointerventional Corporation Closure device for percutaneous occlusion of puncture sites and tracts in the human body and method
US5951589A (en) 1997-02-11 1999-09-14 Biointerventional Corporation Expansile device for use in blood vessels and tracts in the body and tension application device for use therewith and method
US5851232A (en) 1997-03-15 1998-12-22 Lois; William A. Venous stent
US5800454A (en) * 1997-03-17 1998-09-01 Sarcos, Inc. Catheter deliverable coiled wire thromboginic apparatus and method
US5836913A (en) 1997-05-02 1998-11-17 Innerdyne, Inc. Device and method for accessing a body cavity
US5855597A (en) 1997-05-07 1999-01-05 Iowa-India Investments Co. Limited Stent valve and stent graft for percutaneous surgery
US5868708A (en) 1997-05-07 1999-02-09 Applied Medical Resources Corporation Balloon catheter apparatus and method
US5911734A (en) 1997-05-08 1999-06-15 Embol-X, Inc. Percutaneous catheter and guidewire having filter and medical device deployment capabilities
US5846260A (en) 1997-05-08 1998-12-08 Embol-X, Inc. Cannula with a modular filter for filtering embolic material
US5957940A (en) 1997-06-30 1999-09-28 Eva Corporation Fasteners for use in the surgical repair of aneurysms
US5928260A (en) 1997-07-10 1999-07-27 Scimed Life Systems, Inc. Removable occlusion system for aneurysm neck
US5928192A (en) 1997-07-24 1999-07-27 Embol-X, Inc. Arterial aspiration
ATE339919T1 (de) * 1997-08-04 2006-10-15 Boston Scient Ltd Okklussionssystem zum ausbessern eines aneurysmas
DE69834920T2 (de) * 1997-08-05 2007-05-24 Boston Scientific Ltd., St. Michael Ablösbares system zum verschliessen eines aneurysmashalses
US6063070A (en) 1997-08-05 2000-05-16 Target Therapeutics, Inc. Detachable aneurysm neck bridge (II)
DE29714242U1 (de) * 1997-08-08 1998-12-10 Applied Biometrics Verschlußeinrichtung zum Verschließen einer körperlichen Anomalie wie Gefäßöffnung oder Öffnung in einer Scheidewand
US5976174A (en) 1997-12-15 1999-11-02 Ruiz; Carlos E. Medical hole closure device and methods of use
US6036720A (en) * 1997-12-15 2000-03-14 Target Therapeutics, Inc. Sheet metal aneurysm neck bridge
US6007557A (en) 1998-04-29 1999-12-28 Embol-X, Inc. Adjustable blood filtration system
US5935148A (en) 1998-06-24 1999-08-10 Target Therapeutics, Inc. Detachable, varying flexibility, aneurysm neck bridge
US5954694A (en) 1998-08-07 1999-09-21 Embol-X, Inc. Nested tubing sections and methods for making same
US6033420A (en) 1998-09-02 2000-03-07 Embol-X, Inc. Trocar introducer system and methods of use
US6007523A (en) 1998-09-28 1999-12-28 Embol-X, Inc. Suction support and method of use
US6051014A (en) 1998-10-13 2000-04-18 Embol-X, Inc. Percutaneous filtration catheter for valve repair surgery and methods of use
US6152144A (en) * 1998-11-06 2000-11-28 Appriva Medical, Inc. Method and device for left atrial appendage occlusion
US6068621A (en) 1998-11-20 2000-05-30 Embol X, Inc. Articulating cannula
US6080183A (en) 1998-11-24 2000-06-27 Embol-X, Inc. Sutureless vessel plug and methods of use
US6056720A (en) 1998-11-24 2000-05-02 Embol-X, Inc. Occlusion cannula and methods of use
US6083239A (en) 1998-11-24 2000-07-04 Embol-X, Inc. Compliant framework and methods of use
US6024755A (en) 1998-12-11 2000-02-15 Embol-X, Inc. Suture-free clamp and sealing port and methods of use
GB9828039D0 (en) * 1998-12-18 1999-02-17 Sgs Thomson Microelectronics Comparator circuits
US6206907B1 (en) * 1999-05-07 2001-03-27 Cardia, Inc. Occlusion device with stranded wire support arms
US6551303B1 (en) * 1999-10-27 2003-04-22 Atritech, Inc. Barrier device for ostium of left atrial appendage
US6652555B1 (en) * 1999-10-27 2003-11-25 Atritech, Inc. Barrier device for covering the ostium of left atrial appendage
US6689150B1 (en) * 1999-10-27 2004-02-10 Atritech, Inc. Filter apparatus for ostium of left atrial appendage

Cited By (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100413471C (zh) * 2004-06-25 2008-08-27 深圳市先健科技股份有限公司 输送左心耳闭塞装置的输送器
US9510835B2 (en) 2005-10-19 2016-12-06 Pulsar Vascular, Inc. Methods and systems for endovascularly clipping and repairing lumen and tissue defects
US10499927B2 (en) 2005-10-19 2019-12-10 Pulsar Vascular, Inc. Methods and systems for endovascularly clipping and repairing lumen and tissue defects
US11185333B2 (en) 2008-09-05 2021-11-30 Pulsar Vascular, Inc. Systems and methods for supporting or occluding a physiological opening or cavity
US10285709B2 (en) 2008-09-05 2019-05-14 Pulsar Vascular, Inc. Systems and methods for supporting or occluding a physiological opening or cavity
US9615831B2 (en) 2008-09-05 2017-04-11 Pulsar Vascular, Inc. Systems and methods for supporting or occluding a physiological opening or cavity
US11633189B2 (en) 2009-09-04 2023-04-25 Pulsar Vascular, Inc. Systems and methods for enclosing an anatomical opening
US10335153B2 (en) 2009-09-04 2019-07-02 Pulsar Vascular, Inc. Systems and methods for enclosing an anatomical opening
CN103118602A (zh) * 2010-06-11 2013-05-22 随行医疗技术公司 用于经心尖介入和闭合的系统和方法
CN103118602B (zh) * 2010-06-11 2016-04-27 随行医疗技术公司 用于经心尖介入和闭合的系统和方法
US10004510B2 (en) 2011-06-03 2018-06-26 Pulsar Vascular, Inc. Systems and methods for enclosing an anatomical opening, including shock absorbing aneurysm devices
US11344311B2 (en) 2011-06-03 2022-05-31 Pulsar Vascular, Inc. Aneurysm devices with additional anchoring mechanisms and associated systems and methods
US10624647B2 (en) 2011-06-03 2020-04-21 Pulsar Vascular, Inc. Aneurysm devices with additional anchoring mechanisms and associated systems and methods
CN107137114A (zh) * 2011-06-17 2017-09-08 库拉希尔公司 用于瘘治疗的装置及方法
US11457923B2 (en) 2011-10-05 2022-10-04 Pulsar Vascular, Inc. Devices, systems and methods for enclosing an anatomical opening
US9636117B2 (en) 2011-10-05 2017-05-02 Pulsar Vascular, Inc. Devices, systems and methods for enclosing an anatomical opening
US10426487B2 (en) 2011-10-05 2019-10-01 Pulsar Vascular, Inc. Devices, systems and methods for enclosing an anatomical opening
CN104039241A (zh) * 2011-11-08 2014-09-10 W.L.戈尔及同仁股份有限公司 密封装置和递送系统
CN103040492A (zh) * 2013-01-09 2013-04-17 何泽锋 自动控制收缩的经口输送钉砧装置
CN103040492B (zh) * 2013-01-09 2015-04-08 何泽锋 自动控制收缩的经口输送钉砧装置
US10206799B2 (en) 2013-03-22 2019-02-19 Edwards Lifesciences Corporation Device and method for increasing flow through the left atrial appendage
US9849011B2 (en) 2013-03-22 2017-12-26 Edwards Lifesciences Corporation Device and method for increasing flow through the left atrial appendage
CN105050540A (zh) * 2013-03-22 2015-11-11 爱德华兹生命科学公司 用于增加通过左心耳的流动的设备和方法
CN105491964A (zh) * 2013-06-26 2016-04-13 W.L.戈尔及同仁股份有限公司 空间填充装置
CN105491964B (zh) * 2013-06-26 2018-04-13 W.L.戈尔及同仁股份有限公司 空间填充装置
CN103536366A (zh) * 2013-10-22 2014-01-29 同济大学 一种用于柔性微创手术机械手的自动锚爪支撑装置
CN106413589A (zh) * 2014-06-11 2017-02-15 奥特鲁泰克控股有限公司 左心耳封堵器
CN107750145A (zh) * 2015-06-19 2018-03-02 皇家飞利浦有限公司 针对心脏组织的可植入医学设备和系统
CN105520765A (zh) * 2016-01-29 2016-04-27 上海形状记忆合金材料有限公司 凹入式左心耳封堵器
CN106075619A (zh) * 2016-08-26 2016-11-09 复旦大学附属中山医院 一种冠状静脉血流引流器
CN106214289A (zh) * 2016-09-05 2016-12-14 广东脉搏医疗科技有限公司 一种心脏减容植入体
CN106344100A (zh) * 2016-10-11 2017-01-25 北京工业大学 左心耳封堵器
CN110612073A (zh) * 2017-01-05 2019-12-24 和谐发展集团有限公司 用于捕获反流射流、体积及力以实现心室功能及重塑的可扩张装置
CN110612073B (zh) * 2017-01-05 2022-06-07 和谐发展集团有限公司 用于捕获反流射流、体积及力以实现心室功能及重塑的可扩张装置
US11883289B2 (en) 2017-06-28 2024-01-30 Harmony Development Group, Inc. Force transducting inflatable implant system including a dual force annular transduction implant
CN107595347A (zh) * 2017-09-25 2018-01-19 潘湘斌 一种可重复收放的左心耳封堵器组件及其介入方法
US11167122B2 (en) 2018-03-05 2021-11-09 Harmony Development Group, Inc. Force transducting implant system for the mitigation of atrioventricular pressure gradient loss and the restoration of healthy ventricular geometry
CN109620490A (zh) * 2018-12-17 2019-04-16 中国医学科学院北京协和医院 一种爪形胆管及胰腺支架取出器械
CN112336409B (zh) * 2019-08-07 2022-04-08 合硕生技股份有限公司 骨骼钻孔盖固定装置
CN112336409A (zh) * 2019-08-07 2021-02-09 合硕生技股份有限公司 骨骼钻孔盖固定装置
CN111110400B (zh) * 2019-12-09 2022-02-22 先健科技(深圳)有限公司 心脏瓣膜系绳及具有其的心脏瓣膜组件
CN111110400A (zh) * 2019-12-09 2020-05-08 先健科技(深圳)有限公司 心脏瓣膜系绳及具有其的心脏瓣膜组件
CN113855133A (zh) * 2021-09-29 2021-12-31 复旦大学附属中山医院 一种血管吻合口球囊血流隔绝器
CN113855133B (zh) * 2021-09-29 2024-04-09 复旦大学附属中山医院 一种血管吻合口球囊血流隔绝器

Also Published As

Publication number Publication date
EP1579823A2 (en) 2005-09-28
US8221445B2 (en) 2012-07-17
US20050049573A1 (en) 2005-03-03
DE60017928D1 (de) 2005-03-10
EP1225843B1 (en) 2005-02-02
ES2232516T3 (es) 2005-06-01
DE60017928T2 (de) 2005-06-23
US6949113B2 (en) 2005-09-27
AU779124B2 (en) 2005-01-06
US20030120337A1 (en) 2003-06-26
IL149300A0 (en) 2002-11-10
ATE288231T1 (de) 2005-02-15
CA2388603A1 (en) 2001-05-03
US20120283773A1 (en) 2012-11-08
US6730108B2 (en) 2004-05-04
AU2299001A (en) 2001-05-08
WO2001030268A1 (en) 2001-05-03
EP1225843A1 (en) 2002-07-31
US20030191526A1 (en) 2003-10-09
JP2003512129A (ja) 2003-04-02
US6551303B1 (en) 2003-04-22

Similar Documents

Publication Publication Date Title
CN1399531A (zh) 左心房附件口的阻挡装置
JP7071350B2 (ja) 左心耳を排除するためのデバイスおよび方法
US20180338824A1 (en) Filter apparatus for ostium of left atrial appendage
JP2022519720A (ja) 左心耳を排除するためのデバイスおよび方法
CN103747750B (zh) 块状支架装置和使用方法
CN1091584C (zh) 预制导管导引的闭塞器械
US20040098031A1 (en) Method and device for left atrial appendage occlusion
CA2461533A1 (en) A method, a device, and a system for organ reconditioning and a device for preserving an internal bodyorgan
JP7366933B2 (ja) 左心耳を排除するためのデバイスおよび方法
JPS5892360A (ja) 皮ふ横断移植用装置
CN115998361A (zh) 心脏治疗装置
AU2004226914B2 (en) Barrier Device for Ostium of Left Atrial Appendage
EP4171398A1 (en) Methods and apparatus for occluding the left atrial appendage

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C02 Deemed withdrawal of patent application after publication (patent law 2001)
WD01 Invention patent application deemed withdrawn after publication