DE06075479T1 - Vorbeugung und Behandlung von amyloidogener Krankheit - Google Patents
Vorbeugung und Behandlung von amyloidogener Krankheit Download PDFInfo
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- DE06075479T1 DE06075479T1 DE06075479T DE06075479T DE06075479T1 DE 06075479 T1 DE06075479 T1 DE 06075479T1 DE 06075479 T DE06075479 T DE 06075479T DE 06075479 T DE06075479 T DE 06075479T DE 06075479 T1 DE06075479 T1 DE 06075479T1
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- 201000010099 disease Diseases 0.000 title claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title claims 3
- 102000009091 Amyloidogenic Proteins Human genes 0.000 title 1
- 108010048112 Amyloidogenic Proteins Proteins 0.000 title 1
- 230000003942 amyloidogenic effect Effects 0.000 title 1
- 230000002265 prevention Effects 0.000 title 1
- 239000004480 active ingredient Substances 0.000 claims abstract 14
- 102000014914 Carrier Proteins Human genes 0.000 claims abstract 12
- 108010078791 Carrier Proteins Proteins 0.000 claims abstract 12
- 108090000765 processed proteins & peptides Proteins 0.000 claims abstract 10
- 239000012634 fragment Substances 0.000 claims abstract 9
- 230000028993 immune response Effects 0.000 claims abstract 8
- 230000001681 protective effect Effects 0.000 claims abstract 6
- 230000001225 therapeutic effect Effects 0.000 claims abstract 6
- 239000013543 active substance Substances 0.000 claims abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 6
- 150000001413 amino acids Chemical class 0.000 claims 4
- 208000024827 Alzheimer disease Diseases 0.000 claims 3
- 239000002671 adjuvant Substances 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 229960003983 diphtheria toxoid Drugs 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 2
- 108020001507 fusion proteins Proteins 0.000 claims 2
- 102000037865 fusion proteins Human genes 0.000 claims 2
- 208000037259 Amyloid Plaque Diseases 0.000 claims 1
- 108010071134 CRM197 (non-toxic variant of diphtheria toxin) Proteins 0.000 claims 1
- 102000009016 Cholera Toxin Human genes 0.000 claims 1
- 108010049048 Cholera Toxin Proteins 0.000 claims 1
- 102000016607 Diphtheria Toxin Human genes 0.000 claims 1
- 108010053187 Diphtheria Toxin Proteins 0.000 claims 1
- 241000588724 Escherichia coli Species 0.000 claims 1
- 241000237858 Gastropoda Species 0.000 claims 1
- 108060003951 Immunoglobulin Proteins 0.000 claims 1
- 108010058846 Ovalbumin Proteins 0.000 claims 1
- 108010071390 Serum Albumin Proteins 0.000 claims 1
- 102000007562 Serum Albumin Human genes 0.000 claims 1
- 102000009843 Thyroglobulin Human genes 0.000 claims 1
- 108010034949 Thyroglobulin Proteins 0.000 claims 1
- 230000002238 attenuated effect Effects 0.000 claims 1
- 244000052616 bacterial pathogen Species 0.000 claims 1
- 210000004556 brain Anatomy 0.000 claims 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
- 238000010382 chemical cross-linking Methods 0.000 claims 1
- 108060003552 hemocyanin Proteins 0.000 claims 1
- 230000008105 immune reaction Effects 0.000 claims 1
- 102000018358 immunoglobulin Human genes 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 229940092253 ovalbumin Drugs 0.000 claims 1
- 239000002245 particle Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 229920001184 polypeptide Polymers 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 229960000814 tetanus toxoid Drugs 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
- 229960002175 thyroglobulin Drugs 0.000 claims 1
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Abstract
Konjugat,
das einen an ein Trägerprotein
gebundenen Wirkstoff umfasst, wobei der Wirkstoff:
(i) Aβ,
(ii) ein Aβ-Fragment, das ein Epitop enthält, das eine ähnliche schützende oder therapeutische Immunreaktion nach Verabreichung an einen Patienten wie ein Aβ-Peptid induziert, oder
(iii) ein Analogon oder Mimetikum von (i) oder (ii) ist, wobei das Analogon oder Mimetikum ein Epitop enthält, das eine ähnliche schützende oder therapeutische Immunreaktion nach Verabreichung an einen Patienten wie ein Aβ-Peptid induziert, und
wobei das Trägerprotein eine Immunreaktion gegenüber Aβ erhöht.
(i) Aβ,
(ii) ein Aβ-Fragment, das ein Epitop enthält, das eine ähnliche schützende oder therapeutische Immunreaktion nach Verabreichung an einen Patienten wie ein Aβ-Peptid induziert, oder
(iii) ein Analogon oder Mimetikum von (i) oder (ii) ist, wobei das Analogon oder Mimetikum ein Epitop enthält, das eine ähnliche schützende oder therapeutische Immunreaktion nach Verabreichung an einen Patienten wie ein Aβ-Peptid induziert, und
wobei das Trägerprotein eine Immunreaktion gegenüber Aβ erhöht.
Claims (31)
- Konjugat, das einen an ein Trägerprotein gebundenen Wirkstoff umfasst, wobei der Wirkstoff: (i) Aβ, (ii) ein Aβ-Fragment, das ein Epitop enthält, das eine ähnliche schützende oder therapeutische Immunreaktion nach Verabreichung an einen Patienten wie ein Aβ-Peptid induziert, oder (iii) ein Analogon oder Mimetikum von (i) oder (ii) ist, wobei das Analogon oder Mimetikum ein Epitop enthält, das eine ähnliche schützende oder therapeutische Immunreaktion nach Verabreichung an einen Patienten wie ein Aβ-Peptid induziert, und wobei das Trägerprotein eine Immunreaktion gegenüber Aβ erhöht.
- Konjugat nach Anspruch 1, wobei das Trägerprotein: ein Serumalbumin, Hämocyanin der Schlüssellochschnecke, ein Immunglobulinmolekül, Thyroglobulin, Ovalbumin oder ein Toxoid von einem pathogenen Bakterium ist.
- Konjugat nach Anspruch 2, wobei das Trägerprotein Tetanustoxoid, Diphtherietoxoid, E. coli-Toxoid oder H. pylori-Toxoid ist.
- Konjugat nach Anspruch 3, wobei das Diphtherietoxoid attenuiertes Diphtherietoxin CRM 197 ist.
- Konjugat nach Anspruch 1, wobei das Trägerprotein Choleratoxin ist.
- Konjugat nach einem der Ansprüche 1 bis 5, wobei der Wirkstoff an das Trägerprotein durch chemisches Vernetzen gebunden ist.
- Konjugat nach einem der Ansprüche 1 bis 5, wobei der Wirkstoff als ein Fusionsprotein mit dem Trägerprotein exprimiert wird.
- Konjugat nach Anspruch 7, wobei der Wirkstoff an dem Amino-Terminus an das Trägerprotein gebunden ist.
- Konjugat nach Anspruch 7, wobei der Wirkstoff an dem Carboxyl-Terminus an das Trägerprotein gebunden ist.
- Konjugat nach Anspruch 7, wobei der Wirkstoff intern an das Trägerprotein gebunden ist.
- Konjugat nach einem der Ansprüche 7 bis 10, wobei vielfache Wiederholungen des Wirkstoffs in dem Fusionsprotein vorhanden sind.
- Konjugat nach einem der Ansprüche 1 bis 11, wobei der Wirkstoff ein Aβ-Fragment ist, das ein Epitop enthält, das eine ähnliche schützende oder therapeutische Immunreaktion nach Verabreichung an einen Patienten wie ein Aβ-Peptid induziert.
- Konjugat nach Anspruch 12, wobei das Aβ-Fragment von der N-terminalen Hälfte von Aβ herrührt.
- Konjugat nach Anspruch 12 oder Anspruch 13, wobei das Aβ-Fragment mindestens drei zusammenhängende Aminosäuren von einem natürlichen Aβ-Peptid umfasst.
- Konjugat nach Anspruch 14, wobei das Aβ-Fragment mindestens 5 zusammenhängende Aminosäuren von einem natürlichen Aβ-Peptid umfasst.
- Konjugat nach Anspruch 15, wobei das Aβ-Fragment mindestens 6 zusammenhängende Aminosäuren von einem natürlichen Aβ-Peptid umfasst.
- Konjugat nach einem der Ansprüche 12 bis 15, wobei das Aβ-Fragment: Aβ1-5 oder Aβ1-6 ist.
- Konjugat nach einem der Ansprüche 1 bis 11, wobei der Wirkstoff ein Analogon oder Mimetikum von (i) oder (ii) ist, wobei das Analogon oder Mimetikum ein Epitop enthält, das eine ähnliche schützende oder therapeutische Immunreaktion nach Verabreichung an einen Patienten wie ein Aβ-Peptid induziert.
- Konjugat nach Anspruch 18, wobei das Analogon mindestens 90% Sequenzidentität zu dem natürlichen Aβ oder Aβ-Fragment aufweist.
- Konjugat gemäß einem der Ansprüche 1 bis 19, wobei der Wirkstoff Teil eines längeren Polypeptids ist, das den Wirkstoff zusammen mit anderen Aminosäuren beinhaltet.
- Konjugat nach Anspruch 1, wobei der Wirkstoff eine Komponente eines Partikels ist.
- Konjugat nach einem der Ansprüche 1 bis 21 für eine Verwendung in der Therapie.
- Pharmazeutische Zusammensetzung, die ein Konjugat gemäß einem der Ansprüche 1 bis 22 und eine oder mehrere pharmazeutisch verträgliche Komponenten umfasst.
- Pharmazeutische Zusammensetzung gemäß Anspruch 23, die ein Exzipienz umfasst, das für einen oralen Verabreichungsweg oder andere Verabreichungswege geeignet ist.
- Pharmazeutische Zusammensetzung gemäß Anspruch 23 oder Anspruch 24, die ein pharmazeutisch verträgliches Adjuvanz umfasst.
- Pharmazeutische Zusammensetzung gemäß Anspruch 25, wobei das Adjuvanz für eine gleichzeitige Verabreichung mit dem Wirkstoff vorgesehen ist.
- Pharmazeutische Zusammensetzung gemäß Anspruch 26, wobei der Wirkstoff an das Adjuvanz gekoppelt ist.
- Pharmazeutische Zusammensetzung gemäß Anspruch 25, wobei das Adjuvanz für eine Verabreichung vor oder nach dem Wirkstoff vorgesehen ist.
- Verwendung eines Konjugats gemäß einem der Ansprüche 1 bis 22 zur Herstellung eines Medikaments zum Induzieren einer Immunreaktion gegenüber Aβ und dadurch zur Verhinderung oder Behandlung einer Erkrankung, die mit Amyloidablagerungen von Aβ in dem Gehirn eines Patienten assoziiert ist.
- Verwendung nach Anspruch 29, wobei die Erkrankung Alzheimerkrankheit ist.
- Verwendung nach Anspruch 29 oder Anspruch 30, wobei der Patient: (a) asymptomatisch und/oder (b) unter 50 ist und/oder (i) vererbte Risikofaktoren, die eine Prädisposition gegenüber Alzheimerkrankheit anzeigen, aufweist oder (ii) keine bekannten Risikofaktoren für Alzheimerkrankheit aufweist.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US6774097P | 1997-12-02 | 1997-12-02 | |
US67740P | 1997-12-02 | ||
US8097098P | 1998-04-07 | 1998-04-07 | |
US80970P | 1998-04-07 |
Publications (1)
Publication Number | Publication Date |
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DE06075479T1 true DE06075479T1 (de) | 2006-11-16 |
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ID=26748211
Family Applications (7)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE06075704T Pending DE06075704T1 (de) | 1997-12-02 | 1998-11-30 | Vorbeugung und Behandlung von amyloidogener Krankheit |
DE06075479T Pending DE06075479T1 (de) | 1997-12-02 | 1998-11-30 | Vorbeugung und Behandlung von amyloidogener Krankheit |
DE1033996T Pending DE1033996T1 (de) | 1997-12-02 | 1998-11-30 | Vorbeugung und behandlung von amyloidogener krankheit |
DE69839647T Expired - Lifetime DE69839647D1 (de) | 1997-12-02 | 1998-11-30 | Vorbeugung und behandlung von amyloidogener krankheit |
DE69840922T Expired - Lifetime DE69840922D1 (de) | 1997-12-02 | 1998-11-30 | Vorbeugung und Behandlung von amyloidogener Krankheit |
DE69840969T Expired - Lifetime DE69840969D1 (de) | 1997-12-02 | 1998-11-30 | Vorbeugung und Behandlung von amyloidogener Krankheit |
DE69842082T Expired - Lifetime DE69842082D1 (de) | 1997-12-02 | 1998-11-30 | Verhinderung und Behandlung der amyloidogenen Erkrankung |
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DE69839647T Expired - Lifetime DE69839647D1 (de) | 1997-12-02 | 1998-11-30 | Vorbeugung und behandlung von amyloidogener krankheit |
DE69840922T Expired - Lifetime DE69840922D1 (de) | 1997-12-02 | 1998-11-30 | Vorbeugung und Behandlung von amyloidogener Krankheit |
DE69840969T Expired - Lifetime DE69840969D1 (de) | 1997-12-02 | 1998-11-30 | Vorbeugung und Behandlung von amyloidogener Krankheit |
DE69842082T Expired - Lifetime DE69842082D1 (de) | 1997-12-02 | 1998-11-30 | Verhinderung und Behandlung der amyloidogenen Erkrankung |
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2003
- 2003-11-07 US US10/703,713 patent/US20040171815A1/en not_active Abandoned
- 2003-11-07 US US10/704,070 patent/US20040171816A1/en not_active Abandoned
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2004
- 2004-02-27 US US10/789,273 patent/US20050249725A1/en not_active Abandoned
- 2004-03-31 US US10/816,380 patent/US7014855B2/en not_active Expired - Lifetime
- 2004-03-31 US US10/815,404 patent/US6982084B2/en not_active Expired - Lifetime
- 2004-03-31 US US10/815,353 patent/US6808712B2/en not_active Expired - Lifetime
- 2004-08-20 US US10/923,605 patent/US20050249727A1/en not_active Abandoned
- 2004-08-20 US US10/923,474 patent/US20050048049A1/en not_active Abandoned
- 2004-08-20 US US10/923,471 patent/US8535673B2/en not_active Expired - Fee Related
- 2004-08-20 US US10/923,267 patent/US20050191292A1/en not_active Abandoned
- 2004-08-20 US US10/923,469 patent/US8034339B2/en not_active Expired - Fee Related
- 2004-08-27 US US10/928,926 patent/US20050196399A1/en not_active Abandoned
- 2004-09-02 US US10/934,609 patent/US6946135B2/en not_active Expired - Lifetime
- 2004-09-02 US US10/933,559 patent/US6972127B2/en not_active Expired - Lifetime
- 2004-09-02 US US10/934,819 patent/US20050163788A1/en not_active Abandoned
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2005
- 2005-02-14 US US11/058,757 patent/US20050142132A1/en not_active Abandoned
- 2005-04-15 US US11/108,102 patent/US20050191314A1/en not_active Abandoned
- 2005-10-07 US US11/245,916 patent/US20060029611A1/en not_active Abandoned
- 2005-10-07 US US11/245,524 patent/US20060034858A1/en not_active Abandoned
- 2005-11-30 JP JP2005346511A patent/JP4677334B2/ja not_active Expired - Lifetime
- 2005-11-30 JP JP2005346462A patent/JP4677333B2/ja not_active Expired - Lifetime
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2007
- 2007-01-12 HK HK07100441.8A patent/HK1095265A1/xx not_active IP Right Cessation
- 2007-02-13 HK HK07101687.9A patent/HK1094535A1/xx not_active IP Right Cessation
- 2007-08-20 US US11/842,116 patent/US8642044B2/en not_active Expired - Lifetime
- 2007-08-20 US US11/842,120 patent/US20080227719A1/en not_active Abandoned
- 2007-08-20 US US11/842,113 patent/US8034348B2/en not_active Expired - Fee Related
- 2007-08-20 US US11/842,085 patent/US20080096818A1/en not_active Abandoned
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2008
- 2008-06-03 IL IL191904A patent/IL191904A/en not_active IP Right Cessation
- 2008-08-05 IL IL193245A patent/IL193245A0/en unknown
- 2008-09-10 CY CY20081100977T patent/CY1108331T1/el unknown
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2009
- 2009-08-21 NO NO20092874A patent/NO331425B1/no not_active IP Right Cessation
- 2009-09-16 CY CY20091100951T patent/CY1109368T1/el unknown
- 2009-10-26 HR HR20090568A patent/HRP20090568A2/hr not_active Application Discontinuation
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2010
- 2010-01-15 NO NO20100061A patent/NO332813B1/no not_active IP Right Cessation
- 2010-04-22 IL IL205298A patent/IL205298A0/en unknown
- 2010-06-01 JP JP2010126015A patent/JP2010215651A/ja active Pending
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2011
- 2011-03-28 CY CY20111100331T patent/CY1111370T1/el unknown
- 2011-10-10 US US13/270,015 patent/US20130058869A1/en not_active Abandoned
- 2011-10-11 US US13/271,081 patent/US20120276116A1/en not_active Abandoned
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2013
- 2013-09-03 US US14/017,177 patent/US20140227274A1/en not_active Abandoned
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