DE10120543A1 - Drug pump with programmed delivery rate - Google Patents

Drug pump with programmed delivery rate

Info

Publication number
DE10120543A1
DE10120543A1 DE10120543A DE10120543A DE10120543A1 DE 10120543 A1 DE10120543 A1 DE 10120543A1 DE 10120543 A DE10120543 A DE 10120543A DE 10120543 A DE10120543 A DE 10120543A DE 10120543 A1 DE10120543 A1 DE 10120543A1
Authority
DE
Germany
Prior art keywords
pump
pump according
cam
drug
drugs
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE10120543A
Other languages
German (de)
Inventor
Ruediger Groening
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to DE10120543A priority Critical patent/DE10120543A1/en
Priority to DE20122407U priority patent/DE20122407U1/en
Priority to PCT/EP2002/004662 priority patent/WO2002087665A1/en
Publication of DE10120543A1 publication Critical patent/DE10120543A1/en
Priority to DE202005008808U priority patent/DE202005008808U1/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A61M5/1452—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons
    • A61M5/1456—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons with a replaceable reservoir comprising a piston rod to be moved into the reservoir, e.g. the piston rod is part of the removable reservoir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A61M5/1452—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
    • A61M5/16877—Adjusting flow; Devices for setting a flow rate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/28—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle
    • A61M5/281—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle using emptying means to expel or eject media, e.g. pistons, deformation of the ampoule, or telescoping of the ampoule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/31576—Constructional features or modes of drive mechanisms for piston rods
    • A61M5/31578—Constructional features or modes of drive mechanisms for piston rods based on axial translation, i.e. components directly operatively associated and axially moved with plunger rod
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/31576—Constructional features or modes of drive mechanisms for piston rods
    • A61M5/31583—Constructional features or modes of drive mechanisms for piston rods based on rotational translation, i.e. movement of piston rod is caused by relative rotation between the user activated actuator and the piston rod
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/3159—Dose expelling manners
    • A61M5/31591—Single dose, i.e. individually set dose administered only once from the same medicament reservoir, e.g. including single stroke limiting means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A61M5/1452—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons
    • A61M2005/14533—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons cam actuated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M2005/2086—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically having piston damping means, e.g. axially or rotationally acting retarders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M2005/3143—Damping means for syringe components executing relative movements, e.g. retarders or attenuators slowing down or timing syringe mechanisms

Abstract

The invention relates to a pump for the time-controlled, metered administration of medicaments, comprising a medicament reservoir, upon which pressure is exerted by means of a plunger. The pressure is regulated by scanning a profile or several profiles, which is/are incorporated into plates, discs, cylinders and/or spirals and said pressure is transmitted to the plunger by means of an adapter.

Description

Die vorliegende Erfindung betrifft eine Arzneimittelpumpe mit vorprogrammierbarer Wirkstofffreisetzung zur Langzeitverabreichung von Arzneistoffen.The present invention relates to a pharmaceutical pump Pre-programmable drug release for long-term administration of Drugs.

Arzneimittelpumpen werden vorzugsweise verwendet, um über mehrere Stunden oder Tage mit einer vorgegebenen gleichmäßigen oder variablen Abgaberate Arzneistofflösungen oder Arzneistoffemulsionen über Katheder und Kanülen parenteral (z. B. subcutan, intravenös, intraperitoneal) beim Menschen oder Tier in den Organismus einzubringen. Arzneimittelpumpen eignen sich auch für die orale, rektale und transdermale Arzneimttelverabreichung.Drug pumps are preferably used to last for several hours or days with a given uniform or variable delivery rate Drug solutions or drug emulsions over catheters and cannulas parenterally (e.g. subcutaneously, intravenously, intraperitoneally) in humans or animals to bring into the organism. Drug pumps are also suitable for the oral, rectal and transdermal drug delivery.

Zur parenteralen Applikation von Arzneistoffen werden implantierbare Infusionspumpen (EP 00513299 B1) und extern tragbare Pumpen (EP 00168472 B1) beschrieben. Pumpen können mit Injektionsspritzen kombiniert werden, aus denen das Arzneimittel durch Vorschub des Spritzenkolbens freigesetzt wird (EP 00142736 B). Eine Steuerung der Freisetzung über eine Gewindestange wird in EP 0916353 beschrieben.Implantable drugs are used for parenteral application of drugs Infusion pumps (EP 00513299 B1) and externally portable pumps (EP 00168472 B1). Pumps can be combined with hypodermic syringes be made up of the drug by advancing the syringe plunger is released (EP 00142736 B). A control of the release via a Threaded rod is described in EP 0916353.

Zur Abgabe des Arzneistoffs aus Pumpen werden unterschiedliche Prinzipien verwendet. In U.S. Pat. 4,386,929 und U.S. Pat. 4,265,241 werden unter Druck stehende ballonartige Arzneistoffreservoirs beschrieben, die sich langsam entleeren. Im Weiteren werden in U.S. Pat. 5,100,389 und U.S. Patent 4,744,786 federdruck- und gasdruckbetriebene Spritzenpumpen beschrieben. Bei Pumpen, die mit einer variablen Freisetzungsrate den Arzneistoff abgeben, dienen meist elektronische Steuerungen zur Regelung der Freisetzung. Elektronische Steuerungen sind für Patienten meist schwer zu bedienen. Fehler können dabei auftreten. Wird bei Spritzenpumpen der Kolbenvorschub durch Schrittmotoren bewirkt, können Ungenauigkeiten in der Wirkstoffdosierung auftreten.There are different principles for dispensing the drug from pumps used. In U.S. Pat. 4,386,929 and U.S. Pat. 4,265,241 are under pressure standing balloon-like drug reservoirs described that slowly Drain. Furthermore, in U.S. Pat. 5,100,389 and U.S. Patent 4,744,786 described spring pressure and gas pressure operated syringe pumps. For pumps, which release the drug with a variable release rate usually serve electronic controls for regulating the release. electronic Controls are usually difficult to operate for patients. Mistakes can occur occur. In the case of syringe pumps, the piston is fed by stepper motors causes inaccuracies in the drug dosage.

Dieser Nachteil wird durch die vorliegende Erfindung behoben. Es handelt sich wie bei anderen Pumpen zur Verabreichung von Arzneistofflösungen bei der vorliegenden Erfindung vorzugsweise um eine Pumpe, bei der ein spritzenartiges Arzneistoffreservoir z. B. über einen Kolben entleert wird. Der Arzneistoff wird vorzugsweise als Lösung über mehrere Stunden abgegeben. Erfindungsgemäß wird die zeitlich gesteuerte Bewegung des Kolbens mit Hilfe von Profilen erreicht, die als sogenannte Nocken auf Platten, Scheiben, Zylindern oder Spiralen eingefräst oder eingeprägt sind. Wird z. B. ein Abtasters gleichmäßig über mehrere Stunden entlang dieses Nockenprofils geführt, so wird jeweils nur soviel Arzneistofflösung aus dem Reservoir freigegeben, wie durch das Nockenprofil vorgegeben ist.This disadvantage is overcome by the present invention. It is about as with other pumps for the administration of drug solutions in the present invention preferably around a pump in which a syringe-like Drug reservoir z. B. is emptied via a piston. The drug will preferably given as a solution over several hours. According to the invention is the time-controlled movement of the piston using profiles reached, the so-called cams on plates, disks, cylinders or Spirals are milled or stamped. Is z. B. a scanner evenly over several hours along this cam profile, so only released as much drug solution from the reservoir as by the Cam profile is specified.

Beispiel 1example 1

In Abb. 1 ist ein Beispiel für eine erfindungsgemäße Ausführung der Arzneimittelpumpe wiedergegeben. Der zeitliche Verlauf der Freisetzung des Arzneimittels (Insulin-Lösung) aus dem Arzneistoffreservoir (Spritze) ist als Wellenprofil auf der Programmkarte A eingefräst. Der Abtaster D wird auf einer Gewindestange gleichmäßig über 24 Stunden in Pfeilrichtung bewegt. Dadurch wird die unter Federdruck (Pfeilrichtung C) stehende Programmkarte mit der mit ihr verbundenen Kolbenstange, die den Kolben im Arzneistoffreservoir bewegt, jeweils nur in dem Ausmaß vorwärtsbewegt, wie durch das auf der Programmkarte A eingefräste Profil möglich ist. Fig. 1 shows an example of an embodiment of the pharmaceutical pump according to the invention. The time course of the release of the drug (insulin solution) from the drug reservoir (syringe) is milled on the program card A as a wave profile. The scanner D is moved on a threaded rod evenly over 24 hours in the direction of the arrow. As a result, the program card, which is under spring pressure (arrow direction C), with the piston rod connected to it, which moves the piston in the drug reservoir, is only moved forward to the extent that is possible by the profile milled on program card A.

Die Ergebnisse von Freigabeuntersuchungen zeigen, dass die Arzneistoffdosierung variabel über einen Zeitraum von 24 Stunden gesteuert werden kann.The results of release studies show that the Drug dosing variably controlled over a period of 24 hours can be.

Beispiel 2Example 2

In Abb. 2 ist ein Beispiel für eine erfindungsgemäße Ausführung der Arzneimittelpumpe wiedergegeben. Die Arzneimttelpumpe besitzt die Form eines sogenannten Insulin-Pens. Ein Insulin-Pen ist eine Injektionsspritze mit einstellbarer Dosierung. Der zeitliche Verlauf der Pumprate der Arzneimittelpumpe ist über ein Profil vorgegeben, das in den Zylinder A eingefräst ist. Durch den Motor C wird der Abtaster D gleichmäßig mit einer Umdrehung innerhalb von 48 Stunden entlang des Profils geführt. Der Kolbenvorschub und damit die Freisetzung aus dem Arzneistoffreservoir ist abhängig von dem Verlauf des Profils. Fig. 2 shows an example of an embodiment of the pharmaceutical pump according to the invention. The drug pump is in the form of a so-called insulin pen. An insulin pen is a syringe with adjustable dosage. The time course of the pumping rate of the drug pump is specified via a profile which is milled into cylinder A. The motor D guides the scanner D uniformly along the profile with one revolution within 48 hours. The piston advance and thus the release from the drug reservoir depends on the profile.

Beispiel 3Example 3

In Abb. 3 ist für eine Insulinpumpe ein über 24 Stunden vorgesehenes Insulinprofil (Abb. 3a und b) und dessen Übertragung auf eine Programmkarte (Abb. 3c) dargestellt. Das in die Programmkarte eingefräste Profil entspricht der gewünschten kumulativen Insulinabgabe. Bei einer gleichmäßigen Bewegung des Abtasters in Pfeilrichtung während der vorgesehene Zeitdauer der Freisetzung wird aus der Spritze über ein Katheder die Insulin-Injektion vorgenommen. Fig. 3 shows an insulin profile for 24 hours for an insulin pump ( Fig. 3a and b) and its transfer to a program card ( Fig. 3c). The profile milled into the program card corresponds to the desired cumulative insulin delivery. If the scanner moves evenly in the direction of the arrow during the intended duration of the release, the syringe is injected via a catheter.

Beispiel 4Example 4

In Abb. 4 sind zwei unterschiedliche Profile zur Steuerung der Arzneistofffreigabe aus den erfindungsgemäßen Pumpen dargestellt. Durch die unterschiedlichen Verläufe wird das Ausmaß der Freisetzung (5,6 mm bzw. 12,9 mm Gesamtkolbenvorschub) und der Verlauf der Wirkstoffabgabe vorgegeben. Fig. 4 shows two different profiles for controlling drug release from the pumps according to the invention. The extent of the release (5.6 mm or 12.9 mm total piston advance) and the course of the drug delivery are predetermined by the different courses.

Beispiel 5Example 5

In Abb. 5 ist das Ergebnis einer Freisetzungsuntersuchung von Insulin aus einer erfindungsgemäßen, mit Programmkarten gesteuerten Insulinpumpe wiedergegeben. Das vorgegebene Profil (geschlossenen Kreise) entspricht dem in Abb. 3 dargestellten Profil. Das Ergebnis der Anwendungsuntersuchung in Abb. 5 (offene Kreise) zeigt, dass die vorgesehene Freisetzung mit hoher Genauigkeit durch die Pumpe eingehalten werden kann. Fig. 5 shows the result of a release study of insulin from an insulin pump according to the invention, controlled by program cards. The given profile (closed circles) corresponds to the profile shown in Fig. 3. The result of the application investigation in Fig. 5 (open circles) shows that the intended release can be maintained with high accuracy by the pump.

Claims (10)

1. Pumpe zur Verabreichung von Arzneistoffen beim Menschen oder Tier mit zeitlich gesteuerter, variabler Dosierung, dadurch gekennzeichnet, dass der Verlauf der Dosierung ganz oder teilweise über ein oder mehrere Profile gesteuert wird, die auf Platten, Scheiben, Zylinder und/oder Spiralen übertragen sind.1. Pump for the administration of drugs in humans or animals with time-controlled, variable dosage, characterized in that the course of the dosage is controlled in whole or in part via one or more profiles that are transferred to plates, disks, cylinders and / or spirals , 2. Pumpe nach Anspruch 1, dadurch gekennzeichnet, dass Arzneistoffe aus einer Zylinderampulle über ein Katheder parenteral verabreicht werden.2. Pump according to claim 1, characterized in that drugs from a cartridge over a Catheters are administered parenterally. 3. Pumpe nach Anspruch 2, dadurch gekennzeichnet, dass als Arzneistoffe Insuline und andere Peptide verabreicht werden.3. Pump according to claim 2, characterized in that as drugs insulins and other peptides be administered. 4. Pumpe nach Anspruch 1, dadurch gekennzeichnet, dass die Pumpe zur oralen, peroralen, rektalen oder transdermalen Verabreichung von Arzneimitteln verwendet wird.4. Pump according to claim 1, characterized in that the pump for oral, peroral, rectal or transdermal drug delivery is used. 5. Pumpe nach Anspruch 1, dadurch gekennzeichnet, dass auswechselbare Nockenplatten, Nockenscheiben, Nockenzylinder oder Nockenspiralen verwendet werden.5. Pump according to claim 1, characterized in that interchangeable cam plates, cam disks, Cam cylinders or cam spirals can be used. 6. Pumpe nach Anspruch 1, dadurch gekennzeichnet, dass das Nockenprofil mechanisch oder elektronisch abgetastet wird.6. Pump according to claim 1, characterized in that the cam profile mechanically or electronically is scanned. 7. Pumpe nach Anspruch 1, dadurch gekennzeichnet, dass die Pumpe mit Elektromotoren oder Federmotoren betrieben wird.7. Pump according to claim 1, characterized in that the pump with electric motors or spring motors is operated. 8. Pumpe nach Anspruch 1, dadurch gekennzeichnet, dass der Pumpvorgang durch Zug- oder Druckfedern unterstützt wird.8. Pump according to claim 1, characterized in that the pumping process by tension or compression springs is supported. 9. Pumpe nach Anspruch 1, dadurch gekennzeichnet, dass bei Spritzenpumpen über eine Einstellvorrichtung zum Vor- und Rückstellen des den Spritzenkolben verschiebenden Stempels eine Erhöhung oder Reduktion der durch die Pumpe abgegebenen Dosis möglich ist.9. Pump according to claim 1, characterized in that in the case of syringe pumps via an adjusting device for advancing and resetting the plunger that moves the plunger It is possible to increase or decrease the dose delivered by the pump. 10. Pumpe nach Anspruch 1, dadurch gekennzeichnet, dass ein Durchflussbegrenzer die maximale Abgaberate der Pumpe begrenzt.10. Pump according to claim 1, characterized in that a flow limiter the maximum delivery rate the pump is limited.
DE10120543A 2001-04-26 2001-04-26 Drug pump with programmed delivery rate Withdrawn DE10120543A1 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
DE10120543A DE10120543A1 (en) 2001-04-26 2001-04-26 Drug pump with programmed delivery rate
DE20122407U DE20122407U1 (en) 2001-04-26 2001-04-26 Pump for administering medicaments to a human or an animal at a rate variable with time is controlled entirely or partially by means of at least one profile located on various elements
PCT/EP2002/004662 WO2002087665A1 (en) 2001-04-26 2002-04-26 Pump for the time-controlled, metered administration of medicaments
DE202005008808U DE202005008808U1 (en) 2001-04-26 2005-04-07 Pump for control of medical substance released into body, comprising curved scanning profile

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10120543A DE10120543A1 (en) 2001-04-26 2001-04-26 Drug pump with programmed delivery rate

Publications (1)

Publication Number Publication Date
DE10120543A1 true DE10120543A1 (en) 2002-11-07

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Family Applications (3)

Application Number Title Priority Date Filing Date
DE20122407U Expired - Lifetime DE20122407U1 (en) 2001-04-26 2001-04-26 Pump for administering medicaments to a human or an animal at a rate variable with time is controlled entirely or partially by means of at least one profile located on various elements
DE10120543A Withdrawn DE10120543A1 (en) 2001-04-26 2001-04-26 Drug pump with programmed delivery rate
DE202005008808U Expired - Lifetime DE202005008808U1 (en) 2001-04-26 2005-04-07 Pump for control of medical substance released into body, comprising curved scanning profile

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DE20122407U Expired - Lifetime DE20122407U1 (en) 2001-04-26 2001-04-26 Pump for administering medicaments to a human or an animal at a rate variable with time is controlled entirely or partially by means of at least one profile located on various elements

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DE202005008808U Expired - Lifetime DE202005008808U1 (en) 2001-04-26 2005-04-07 Pump for control of medical substance released into body, comprising curved scanning profile

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DE (3) DE20122407U1 (en)
WO (1) WO2002087665A1 (en)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7449680B2 (en) 2019-11-25 2024-03-14 ミネベアミツミ株式会社 syringe pump

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DE2609699A1 (en) * 1974-05-28 1977-09-15 Imed Corp Pump with predetermined flow rate and dispensed volume - has volumetric cassette with piston and piston delivery stroke control
US4078562A (en) * 1976-08-16 1978-03-14 Diana W. Friedman Infusion pump with feedback control
DE3239190A1 (en) * 1981-10-22 1983-05-05 Oximetrix, Inc., 94043 Mountain View, Calif. STEPPER MOTOR CONTROL FOR THE QUASI CONTINUOUS FLUID INFUSION OF VARIABLE QUANTITY
EP0354324A2 (en) * 1988-07-08 1990-02-14 I-Flow Corporation Cartridge-type programmable ambulatory infusion pump
US4919650A (en) * 1987-03-30 1990-04-24 Bionica Pty. Limited Infusion pump
EP0393354A1 (en) * 1989-04-15 1990-10-24 B. Braun Melsungen AG Medical pump appliance
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