DE10301026A1 - Stent to be used for percutaneous insertion of artificial heart valve, comprising hook-shaped elements for exact positioning - Google Patents

Stent to be used for percutaneous insertion of artificial heart valve, comprising hook-shaped elements for exact positioning Download PDF

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Publication number
DE10301026A1
DE10301026A1 DE10301026A DE10301026A DE10301026A1 DE 10301026 A1 DE10301026 A1 DE 10301026A1 DE 10301026 A DE10301026 A DE 10301026A DE 10301026 A DE10301026 A DE 10301026A DE 10301026 A1 DE10301026 A1 DE 10301026A1
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Prior art keywords
stent
heart valve
valve
implantation
exact positioning
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DE10301026A
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German (de)
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DE10301026B4 (en
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Markus Dr.med. Dr.disc.pol. Ferrari
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Jenavalve Technology Inc
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Individual
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Priority to DE20321838U priority patent/DE20321838U1/en
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
    • A61F2/2412—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body with soft flexible valve members, e.g. tissue valves shaped like natural valves
    • A61F2/2418—Scaffolds therefor, e.g. support stents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
    • A61F2/2427—Devices for manipulating or deploying heart valves during implantation
    • A61F2/2436—Deployment by retracting a sheath
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2220/00—Fixations or connections for prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2220/0008—Fixation appliances for connecting prostheses to the body
    • A61F2220/0016—Fixation appliances for connecting prostheses to the body with sharp anchoring protrusions, e.g. barbs, pins, spikes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2230/0002—Two-dimensional shapes, e.g. cross-sections
    • A61F2230/0028—Shapes in the form of latin or greek characters
    • A61F2230/0054—V-shaped

Abstract

The folded stent is moved through a catheter to the left ventricle where it is partially released, facilitating the hooks to unfold and to move into a radial position. The elements are gently pushed into the pockets of the aortic valve in order to create a reliable connection like a paper clip holding a sheet of paper, allowing the exact positioning of the stent and preventing a dislocation of same towards the left ventricle.

Description

Gegenwärtiger Stand der Technik:Current state of the art:

Das derzeitige Standardverfahren zum Ersatz menschlicher Herzklappen verwendet gegenwärtig biologische oder mechanische Herzklappenprothesen, welche über eine operative Eröffnung des Brustkorbs nach Entfernung der kranken Herzklappe im Herzklappenbett festgenäht werden. Damit eine Herzklappe eingenäht werden kann, muß der Kreislauf des Patienten durch eine Herz-Lungen-Maschine getragen werden. Es wird ein Herzstillstand induziert und während des Herzstillstandes die Herzklappenprothese eingenäht. Es handelt sich folglich um einen sehr großen chirurgischen Eingriff mit entsprechenden Risiken für den Patienten und eine lange postoperative Behandlungsphase. Der Eingriff ist somit auf jüngere und möglichst gesunde Patienten beschränkt. Sehr alten Patienten und sehr herzschwachen Patienten kann dieser Eingriff nicht mehr zugemutet werden.The current standard procedure Biological valves are currently used to replace human heart valves or mechanical heart valve prostheses, which have an operative opening of the chest after removing the diseased heart valve, be sewn into the heart valve bed. So that a heart valve is sewn in can be, the Circulation of the patient carried by a heart-lung machine become. Cardiac arrest is induced and during the Cardiac arrest, the heart valve prosthesis is sewn on. It is consequently a very big one surgical intervention with corresponding risks for the patient and a long post-operative treatment period. The intervention is thus on younger ones and if possible healthy patients limited. Very old patients and very weak hearted patients can do this Intervention can no longer be expected.

Daher wurde in den letzten Jahren vermehrt nach Verfahren gesucht, welche die erkrankte Herzklappe mittels Katheter perkutan, transluminal ersetzen können. Zu diesem Verfahren, bei welchem eine Herzklappe mittels eines Stents durch einen Katheter am schlagenden herzen minimal-invasiv implantiert werden kann, sind mehrere nationale und internationale Patentente, Patentanmeldung und Gebrauchsmuster erteilt bzw. eingereicht auf die an dieser Stelle verwiesen wird.Therefore, in recent years increasingly searched for procedures that affect the diseased heart valve can be replaced percutaneously, transluminally using a catheter. To this method, in which a heart valve by means of a stent minimally invasively implanted through a catheter on the beating heart can be, several national and international patent ducks, patent application and utility model granted or filed to those referred to here becomes.

Grundlagen des transluminalen Herzklappenersatzes:Basics of transluminal Heart valve replacement:

Allen Verfahren des perkutanen, transluminalen Herzklappenersatzes gemeinsam ist das Vorbringen der zu implantierenden Herzklappenprothese mit einem Katheter, der über ein peripheres Gefäß minimal-invasiv, perkutan eingeführt wird. Die Klappenprothese ist in ein Träger-Stütz-System (Stent) eingebracht, welches aus einem Drahtgeflecht besteht und das bei der Implantation von selbst aufspringt (= selbstexpandierend) oder von einem Ballon aufgelehnt wird (= Ballon expandierbar). Unter Kontrolle von Röntgendurchleuchtung (Herzkatheterlabor = HKL) und Ultraschall (transösophageales Echokardiogramm = TEE) wird über einem Führungsdraht, der zuvor als Leitschiene platziert wurde, der Einführkatheter und die darin befindliche Herzklappen-Stent-Einheit zur Implantationsstelle vorgebracht, wo sich die erkrankte zu ersetzende Klappe befindet. Hier wird der Stent frei gegeben und durch die Stent-Expansion die neu Klappenprothese aufgespannt.All procedures of the percutaneous, transluminal Common heart valve replacement is the submission of the one to be implanted Heart valve prosthesis with a catheter that is minimally invasive via a peripheral vessel, introduced percutaneously becomes. The valve prosthesis is inserted into a carrier-support system (stent), which consists of a wire mesh and that during implantation jumps up by itself (= self-expanding) or from a balloon is rejected (= balloon expandable). Under X-ray control (Cardiac catheter laboratory = HKL) and ultrasound (transesophageal echocardiogram = TEE) is about a guide wire, which was previously placed as a guardrail, the insertion catheter and the heart valve stent unit located therein to the implantation site presented where the diseased valve to be replaced is located. Here, the stent is released and the stent expansion new prosthetic valve.

Nachleile des derzeitigen Verfahrens:Lag of the current procedure:

Als ein zwei wesentliche Nachteile des derzeitigen Verfahrens sind zum einen Probleme bei der sicheren Positionierung des Stents zu sehen, die trotz hoher Auflösung im HKL und des TEE die Gefahr- von Fehlimplantationen birgt. Eine Implantation des Herzklappen-Stents zu weit in der Herzkammer (Ventrikel) führt zur Undichtigkeit (Klappeninsuffizienz) und erheblichen Belastung des Ventrikels. Eine Fehlimplantation zu weit oberhalb der eigentlichen Klappenebene kann zum Verschluss der Abgänge der Herzkranzgefäße (Koronarien) und damit zu einer tödlichen Koronarischämie mit Herzinfarkt führen.As one of two major drawbacks On the one hand, the current procedure presents problems with the safe Positioning of the stent can be seen, which despite the high resolution in the HKL and the TEE harbors the risk of incorrect implantations. An implantation of the Heart valve stents too far in the heart chamber (ventricle) leads to Leakage (valve insufficiency) and considerable stress on the Ventricle. An incorrect implantation too far above the actual valve level can close the outlets of the Coronary arteries and thus a deadly coronary ischemia lead with heart attack.

Des Weiteren muss eine Aortenklappenprothese erhebliche Kräfte während der Diastole aushalten, die eine sichere Verankerung des Herzklappen-Stents voraussetzt, damit dieser nicht in den Ventrikel disloziert. Eine solche Verankerung bieten Widerhaken, welche sich in der Wand der Aorta abstutzen, wie dies in dem deutschen Patent Nr. 195 466 92 dargestellt ist. Eine zusätzliche Veraukerung oder Abstützung wäre jedoch aus Sicherheitsgründen hier wünschenswert.Furthermore, an aortic valve prosthesis considerable forces while endure the diastole, which securely anchors the heart valve stent assumes that it does not dislocate into the ventricle. A such anchoring offers barbs, which are in the wall of the Trim the aorta, as described in German Patent No. 195 466 92 is shown. An additional Sale or support would be however for safety reasons desirable here.

Darstellung der Erfindungpresentation the invention

Der im Patentanspruch angegebenen Erfindung liegen die o.g. Probleme bei der transluminalen Herzklappenimplantation zugrunde, dass Bedarf für die Weiterentwicklung dieses Verfahrens eine sicher Positionierung bei der Implantation und eine zusätzliche Abstützung des Herzklappen-Stents gegen eine ventrikelwärts gerichtete Dislokation besteht.The specified in the claim Invention lie the above. Problems with transluminal heart valve implantation underlying that need for the Further development of this method ensures a safe positioning the implantation and an additional support of the heart valve stent against a ventricular dislocation consists.

Dazu wurde eine Modifikation der derzeitig verfügbaren Stents hinsichtlich der Bauart und damit des Verhaltens bei Implantation und hinsichtlich der Verankerung vorgenommen. Diese Modifikation sieht Bügel / Streben bzw. Ausarbeitungen des Stents vor, welche bei der Implantation in die Taschen der alten Klappe hinein geschoben werden (1). Wie bei der o. g. Implantationstechnik wird der Katheter über einen Führungsdraht mit seinem distalen Ende, in dein sich der Herzklappen-Stent in zusammengefalteten Zustand befindet, bis in den linken Ventrikel vorgeschoben (2). Dort wird zunächst nur ein Teil des Stents freigegeben, so dass sich die Bügel / Streben /Ausarbeitungen des Stents im Bereich der Aortenwurzel radial nach außen stellen. Durch vorsichtiges Vorschieben werden diese in die "Taschen der Aortenklappe eingeschoben, wo sie eine sichere und exakte Plazierung des Herzklappen-Stents ermöglichen. Nach Freigabe des übrigen Herzklappen-Stents Spannt sich dieser mit seinen distalen Bügeln im linksventrikulären Ausflusstrakt, mit dem klappentragenden Segment im Bereich der alten Herzklappe und dem proximalen Anteil in der Aortenwurzel auf. Die Bügel / Streben / Ausarbeitungen des Stents verankern das System und verhindern eine Dislokation in den linken Ventrikel (3 + 4). Wie „Papier zwischen den Bügeln einer Büroklammer" werden die Taschen der alten Klappe zwischen die Bügel / Streben / Ausarbeitungen des Stents und den klappentragenden Anteil des Stents gedrückt.For this purpose, a modification of the currently available stents with regard to the design and thus the behavior during implantation and with regard to anchoring was carried out. This modification provides stirrups / struts or elaborations of the stent, which are pushed into the pockets of the old valve during implantation ( 1 ). As with the implantation technique mentioned above, the distal end of the catheter is advanced over a guide wire into which the heart valve stent is in the folded state, into the left ventricle ( 2 ). Only a part of the stent is initially released there, so that the stirrups / struts / elaborations of the stent are positioned radially outward in the area of the aortic root. Carefully pushing them into the "pockets of the aortic valve, where they allow safe and exact placement of the heart valve stent. After the rest of the heart valve stent has been released, it is stretched with its distal stirrups in the left ventricular outflow tract with the valve-carrying segment in the area the old heart valve and the proximal part in the aortic root. The stent stirrups / struts / elaborations anchor the system and prevent dislocation in the left ventricle ( 3 + 4 ). The pockets of the old flap are like "paper between the brackets of a paper clip" Pressed stirrups / struts / elaborations of the stent and the valve-carrying part of the stent.

Die Bügel / Streben / Ausarbeitungen des Stents gewährleisten somit während der Implantation eine sichere Positionierung durch die anatomischen Strukturen der Taschen der alten Klappe, die neben der Kontrolle im HKL und mittels TEE die exakte Implantation des Herzklappen-Stents erlaubt. Außerdem gewährleistet dieses Konstruktionsmerkmal eine zusätzliche Abstützung in den Taschen und damit am Klappenring der alten Herzklappe, wodurch eine Dislokation des Herzklappen-Stents in Richtung der linken Herzkammer verhindert wird.The stirrups / struts / elaborations ensure the stent thus during the implantation ensures safe positioning through the anatomical structures the pockets of the old flap that are next to the control in the HVAC and allows the exact implantation of the heart valve stent using TEE. In addition guaranteed this design feature an additional support in the pockets and thus on the valve ring of the old heart valve, which creates a Dislocation of the heart valve stent towards the left ventricle is prevented.

Diese Konstruktionsmerkmale des Stents bieten die gleichen Vorzüge auch bei transluminalen Ersatz der Pulmonalklappe. Somit soll das o. g. Verfahren und die beschriebenen Konstruktionsmerkmale des Herzklappen-Stents in Analogie für den Einsatz an der rechten Herzkammer (rechter Ventrikel, Pulmonalklappe, Arteria pulmonalis) gelten.These stent design features provide the same benefits also with transluminal replacement of the pulmonary valve. So that should o. g. Process and the described design features of the Heart valve stents in analogy for use on the right ventricle (right ventricle, pulmonary valve, Pulmonary artery) apply.

Gegenüber den bisherigen Herzklappenprothesen für einen transluminalen Klappenersatz zeichnet sich die Erfindung dadurch aus:

  • 1. Daß der Herzklappen-Stent um Bügel / Streben / Ausarbeitungen ergänzt wird.
  • 2. Daß diese Bügel / Streben / Ausarbeitungen während der ersten Phase der Implantation aus dem Katheter im Bereich der Hauptschlagader (Aortenwiirzel) bzw. im proximalen Anteil der Lungenschlagader (Arteria pulmonalis) freigegeben werden.
  • 3. Daß diese Bügel / Streben / Ausarbeitungen während der Implantation in die Taschen der alten Herzklappe hinein geschoben werden.
  • 4. Daß die Bügel / Streben / Ausarbeitungen eine exaktere Implantation des Herzklappen-Stents ermöglichen.
  • 5. Daß durch diese Modifikation der Bauart des Herzklappen-Stents eine zusätzliche Verankerung des Systems gegen eine Dislokation ermöglicht..
  • 6. Daß diese Modifikation der Bauart des Herzklappen-Stents beim transluminalen Ersatz der Aorten- wie auch der Pulinonalklappe Verwendung finden kann.
Compared to the previous heart valve prostheses for a transluminal valve replacement, the invention is characterized by:
  • 1. That the heart valve stent is supplemented by stirrups / struts / elaborations.
  • 2. That these stirrups / struts / elaborations are released from the catheter in the area of the main artery (aortic root) or in the proximal part of the pulmonary artery (pulmonary artery) during the first phase of implantation.
  • 3. That these stirrups / struts / elaborations are pushed into the pockets of the old heart valve during implantation.
  • 4. That the stirrups / struts / elaborations enable a more precise implantation of the heart valve stent.
  • 5. That this modification of the design of the heart valve stent enables additional anchoring of the system against dislocation.
  • 6. That this modification of the design of the heart valve stent can be used in the transluminal replacement of the aortic as well as the pulinonal valve.

Ausführungsbeispiele der Erfindung sind in den 1 – 4 dargestellt:Embodiments of the invention are in the 1 - 4 shown:

1: Die dargestellte Ausarbeitung des Stents mit zusätzlichen Bügeln / Streben / Ausarbeitungen dienen der mechanischen Stabilisierung und exakten Positionierung des Herzklappen tragenden Stents bei transluminalen Herzklappenersatz. 1 : The shown elaboration of the stent with additional brackets / struts / elaborations serve the mechanical stabilization and exact positioning of the stent-carrying stent with transluminal heart valve replacement.

2: Bei der perkutanen, transluminalen Implantation des Herzklappen-Stents werden die zusätzlichen Bügeln / Streben / Ausarbeitungen in die Taschen der alten zu ersetzenden Klappe vorgeschoben. Nach weiterer Freigabe des Stents aus dem Katheter wird die neue Herzklappenprothese aufgespannt und gleichzeitig die alte Klappe gegen die Wand gepresst. 2 : With the percutaneous, transluminal implantation of the heart valve stent, the additional stirrups / struts / elaborations are pushed into the pockets of the old valve to be replaced. After further release of the stent from the catheter, the new heart valve prosthesis is clamped and at the same time the old valve is pressed against the wall.

3a & b: Nach Einbringen des Implantationskatheters bis auf Ebene der zu ersetzenden, alten Herzklappe wird der distale Teil des Stents freigegeben. Dadurch stellen sich die Bügel / Streben / Ausarbeitungen des Stents (*) im Bereich der Aortenwurzel radial nach außen auf. Durch leichtes Vorschieben werden die Bügel / Streben / Ausarbeitungen des Stents in die Taschen der alten Klappe hinein geschoben und ermöglichen durch die Abstützung an den anatomischen Strukturen der Klappentaschen eine exakte Plazierung des Herzklappen-Stents. 3a & b : After inserting the implantation catheter down to the level of the old heart valve to be replaced, the distal part of the stent is released. As a result, the stirrups / struts / elaborations of the stent (*) are positioned radially outwards in the area of the aortic root. The bow / struts / elaborations of the stent are pushed into the pockets of the old valve by gently pushing them forward and, thanks to the support on the anatomical structures of the valve pockets, allow the heart valve stent to be placed exactly.

4a & b: Durch Stern (*) sind die zusätzlichen Bügeln / Streben / Ausarbeitungen des Herzklappen-Stents gekennzeichnet, die in die Taschen der alten, zu ersetzenden Klappe vorgeschoben werden und dort eine exakte Positionierung und zusätzliche Abstützung / Verankerung gewährleisten. Nach weiterer Freigabe des Stents aus dem des Implantationskatheters werden die Taschen der alten Klappe wie „Papier zwischen den Bügeln einer Büroklammer" zwischen den Bügel / Streben / Ausarbeitungen des Stents und dem sich jetzt aufspannenden, klappentragenden Anteil des Stents eingeklemmt. Nach kompletter Freigabe des Stents ist die darin Eingebrachte Herzklappenprothese in der Position der erkrankten Klappe aufgespannt. 4a & b : The asterisk (*) indicates the additional stirrups / struts / elaborations of the heart valve stent that are pushed into the pockets of the old valve to be replaced and ensure exact positioning and additional support / anchoring there. After further release of the stent from that of the implantation catheter, the pockets of the old valve are clamped like "paper between the stirrups of a paper clip" between the stirrups / struts / elaborations of the stent and the flap-carrying portion of the stent that is now opening. After the stent has been completely released the inserted heart valve prosthesis is stretched in the position of the diseased valve.

Claims (5)

Vorrichtung zur Verankerung und Ausrichtung von Herzklappenprothesen dadurch gekennzeichnet, daß dieser zum transluminalen, perkutanen, minimal-invasiven Ersatz einer erkrankten Taschenklappe (Aorten- oder Pulmonalklappe) dient.Device for anchoring and aligning heart valve prostheses characterized in that this for transluminal, percutaneous, minimally invasive replacement of a diseased Pocket flap (aortic or pulmonary valve) is used. Vorrichtung nach Anspruch 1 dadurch gekennzeichnet, daß diese der exakten Positionierung des Herzklappen-Stents während des Implantationsvorganges dient.Device according to claim 1, characterized in that this the exact positioning of the heart valve stent during the Implantation process. Vorrichtung nach Anspruch 1 oder 2 dadurch gekennzeichnet, daß bei der Implantation die Bügel / Streben / Ausarbeitungen des Stents in die Taschen der zu ersetzenden Herzklappe hinein geschoben werden und dort das System abstutzen.Apparatus according to claim 1 or 2, characterized in that the Implantation of the temples / Striving / elaborations of the stent in the pockets of those to be replaced Heart valve are pushed in and support the system there. Vorrichtung nach Anspruch 1, 2 oder 3 dadurch gekennzeichnet, daß die Bügel / Streben / Ausarbeitungen des Herzklappen-Stents nach der Implantation den Stent gegen eine Dislokation zusätzlich abstützen.Device according to claim 1, 2 or 3, characterized in that that the Hanger / Aspiration / elaboration of the heart valve stent after implantation additionally support the stent against dislocation. Vorrichtung nach Anspruch 1 bis 4 dadurch gekennzeichnet, daß sie zusammenfaltbar und damit in einem Katheter zu implantieren ist.Device according to claims 1 to 4, characterized in that it can be folded up and thus to be implanted in a catheter.
DE10301026.2A 2002-08-13 2003-01-14 Device for anchoring and aligning heart valve prostheses Expired - Lifetime DE10301026B4 (en)

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DE20321838U DE20321838U1 (en) 2002-08-13 2003-01-14 Device for anchoring and aligning heart valve prostheses

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DE10237573.9 2002-08-13
DE10237573 2002-08-13
DE10301026.2A DE10301026B4 (en) 2002-08-13 2003-01-14 Device for anchoring and aligning heart valve prostheses

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WO2007048529A1 (en) * 2005-10-28 2007-05-03 Jenavalve Technology Inc. Device for implanting and fastening heart valve prostheses
EP2201911A3 (en) * 2008-12-23 2010-11-17 Sorin Biomedica Cardio S.r.l. Expandable prosthetic valve having anchoring appendages
US7896915B2 (en) 2007-04-13 2011-03-01 Jenavalve Technology, Inc. Medical device for treating a heart valve insufficiency
US8062355B2 (en) 2005-11-04 2011-11-22 Jenavalve Technology, Inc. Self-expandable medical instrument for treating defects in a patient's heart
US8109996B2 (en) 2004-03-03 2012-02-07 Sorin Biomedica Cardio, S.R.L. Minimally-invasive cardiac-valve prosthesis
US8317858B2 (en) 2008-02-26 2012-11-27 Jenavalve Technology, Inc. Stent for the positioning and anchoring of a valvular prosthesis in an implantation site in the heart of a patient
US8398704B2 (en) 2008-02-26 2013-03-19 Jenavalve Technology, Inc. Stent for the positioning and anchoring of a valvular prosthesis in an implantation site in the heart of a patient
US8465540B2 (en) 2008-02-26 2013-06-18 Jenavalve Technology, Inc. Stent for the positioning and anchoring of a valvular prosthesis
US8468667B2 (en) 2009-05-15 2013-06-25 Jenavalve Technology, Inc. Device for compressing a stent
US8512397B2 (en) 2009-04-27 2013-08-20 Sorin Group Italia S.R.L. Prosthetic vascular conduit
US8540768B2 (en) 2005-02-10 2013-09-24 Sorin Group Italia S.R.L. Cardiac valve prosthesis
US8679174B2 (en) 2005-01-20 2014-03-25 JenaValve Technology, GmbH Catheter for the transvascular implantation of prosthetic heart valves
US8685084B2 (en) 2011-12-29 2014-04-01 Sorin Group Italia S.R.L. Prosthetic vascular conduit and assembly method
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