DE3015279A1 - X=Ray contrast agent aerosol for inhalation - in radiography of the central bronchial system not requiring patient anaesthesia - Google Patents

X=Ray contrast agent aerosol for inhalation - in radiography of the central bronchial system not requiring patient anaesthesia

Info

Publication number
DE3015279A1
DE3015279A1 DE19803015279 DE3015279A DE3015279A1 DE 3015279 A1 DE3015279 A1 DE 3015279A1 DE 19803015279 DE19803015279 DE 19803015279 DE 3015279 A DE3015279 A DE 3015279A DE 3015279 A1 DE3015279 A1 DE 3015279A1
Authority
DE
Germany
Prior art keywords
aerosol
inhalation
contrast agent
patient
anaesthesia
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE19803015279
Other languages
German (de)
Inventor
Peter Dr. 6301 Groß-Linden Hild
Manfred Prof. Dipl.-Ing. 6301 Pohlheim Roth
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to DE19803015279 priority Critical patent/DE3015279A1/en
Publication of DE3015279A1 publication Critical patent/DE3015279A1/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/08—Detecting, measuring or recording devices for evaluating the respiratory organs
    • A61B5/0813—Measurement of pulmonary parameters by tracers, e.g. radioactive tracers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0409—Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is not a halogenated organic compound

Abstract

New device and method are claimed for producing an aerosol which can be inhaled by a patient and which after inhalation gives a radiographic contrast. In the device, temp. and pressure are so adjusted that in the atomisation appts. a droplet spectrum is produced which is suitable for representation of the central bronchial system. The aerosol can be administered to the patient without anaesthesia, and the contrast agent droplets are fully resorbable. Preferably, the aerosol produced in the atomiser appts. is concentrated by application of high voltage in an electric chamber.

Description

Verfahren und Vorrichtung zur Erzeugung eines Method and device for producing a

Aerosols für die Inhalationsbronchographie Die Erfindung betrifft das Verfahren und die Vorrichtung, um aus einem Kontrastmittel ein Aerosol zu erzeugen, mit dessen Hilfe nach Inhalation das zentrale Bronchialsystem röntgenologisch darstellbar ist. Aerosols for Inhalation Bronchography The invention relates to the method and the device for generating an aerosol from a contrast medium, with the help of which the central bronchial system can be shown radiologically after inhalation is.

Zur röntgenologischen Darstellung des zentralen Bronchialsystems wird ein Aerosol inhaliert, das ein bestimmtes, eng begrenztes, Tropfenspektrum aufweist und das über eine geeignete Konzentration im gemisch Trägerluft-Kontrastmittel verfügt. Beide Eigenschaften (2ropfenspektrum, Konzentration) werden von der Erfindung erzeugt.For the radiological representation of the central bronchial system inhales an aerosol that has a specific, narrowly defined range of droplets and that has a suitable concentration in the mixture of carrier air and contrast agent. Both properties (2-drop spectrum, concentration) are produced by the invention.

Die darzustellenden Teile des Patienten, wie z.B. Trachea und große Bronchialäste, werden nach dem jetzigen Stand der Technik mit einer nicht voll resorbierbaren Kontrastmittelsuspension gefüllt und nach der Diagnose wieder abgesaugt.The parts of the patient to be represented, such as the trachea and large According to the current state of the art, bronchial branches are not fully absorbable Contrast medium suspension filled and sucked off again after the diagnosis.

Diese Methode belastet den Patienten sehr stark, da die Untersuchung in Vollnarkose oder zumindest in Teilnarkose erfolgen muß. Die Kontrastmittelsuspension kann weder vollständig resorbiert noch durch Absaugen entfernt werden.This method is very stressful for the patient because of the examination must be done under general anesthesia or at least under partial anesthesia. The contrast medium suspension can neither be completely absorbed nor removed by suction.

Der Erfindung liegt ein Verfahren zugrunde, bei dem mit Hilfe einer Vorrichtung ein Aerosol erzeugt wird, das inhaliert werden kann und das auf Grund seines Tropfenspektrums und seiner Konzentraion befähigt ist, das zentrale Bronchialsysem röntgenologisch darzustellen Das Aerosol kann von einem Patienten ohne Narkose inhaliert werden und ist voll resorbierbar.The invention is based on a method in which with the help of a Device an aerosol is generated that can be inhaled and due to its droplet spectrum and its concentration is capable of that central The aerosol can be taken from a patient can be inhaled without anesthesia and is fully absorbable.

Das Verfahren enthalt die Vorrichtung, die aus einer Sprühvorrichtung besteht, die das für die röntgenologische Darstellung erforderliche Tropfenspektrum erzeugt, und einer elektrischen Kammer, in der mit Hilfe der elektischen Ladung der Kontrastmittelnebel aufkonzentriert wird.The method includes the device consisting of a spray device which has the droplet spectrum required for the radiographic representation generated, and an electric chamber in which with the help of the electric charge the contrast agent mist is concentrated.

dit diesem Verfahren wird der Patient schonend untersucht.With this procedure, the patient is carefully examined.

Er kann das Aerosol durch ein sviundstück inhalieren Schädliche Nachwirkungen treten nicht auf, da das verwendete Kontrastmittel voll resorbierbar ist und über die Nieren ausgeschieden wird Bei Standardisierung des Verfahrens besteht die Möglichkeit der Anwendung als Screening-sIethode.He can inhale the aerosol through a nozzle. Harmful aftereffects do not occur because the contrast agent used is fully absorbable and over the kidneys is excreted If the procedure is standardized, the possibility exists application as a screening method.

In den Zeichnungen sind einige Ausführungsbeispiele dargestellt. Es zeigen: Fig. 1 : Vorrichtung mit Zweistoffdüse Fig. 2 : " mit Einstoffdüse Fig. 3 : " mit Ultraschallvernebler Die Sprühvorrichtung 1 besteht aus einer Einstoff-,Zweistoff üse oder einem Ultraschallvernebler. Sie erzeugt aus dem Kontrastmittel das Aerosol, mit dem das zentrale Bronchialsystem röntgenologisch dargestellt wird. Das Aerosol muß ein eng begrenztes Tropfenspektrum aufweisen.Some exemplary embodiments are shown in the drawings. It show: Fig. 1: Device with two-substance nozzle Fig. 2: "With one-substance nozzle Fig. 3: "with ultrasonic nebulizer The spray device 1 consists of a one-substance, two-substance or an ultrasonic nebulizer. It generates the aerosol from the contrast agent, with which the central bronchial system is shown radiologically. The aerosol must have a narrowly limited range of droplets.

Dieses Spektrum ergibt sich bei geeigneter Yahl von Druck und Temperatur im Aerosol vor der Sprühvorrichtung. Die richtige Einstellung des Druckes geschieht mit der Pumpe 2 in Verbindung mit dem Regelventil 3 und der Druckmessung 4.This spectrum results from a suitable choice of pressure and temperature in the aerosol in front of the spray device. The correct setting of the pressure is done with the pump 2 in connection with the control valve 3 and the pressure measurement 4.

Die richtige Temperatureinstellung erfolgt über den Wärmeübertrager 5 in Verbindung mit der Temperaturmessung 6.The correct temperature setting is made via the heat exchanger 5 in connection with temperature measurement 6.

Bei der Zweistoffdüse ist weiterhin eine Regelung der Trägerluft notwendig, die aus der Druckmessung 11, der Durchflußmessung 12, dem Regelventil 13 und den Preßluftsystem 14 besteht.In the case of the two-substance nozzle, the carrier air must still be regulated, from the pressure measurement 11, the Flow measurement 12, the control valve 13 and the compressed air system 14 consists.

Bei dem Ultraschallvernebler entfällt eine Regelung des Kontrastmittelflusses.With the ultrasonic nebulizer, there is no regulation of the contrast medium flow.

Das Aerosol gelangt in die elaktrische Zelle 8, in der es konzentriert wird. Zum Patienten führt die Leitung 10, die am Ende mit einem Mundstück versehen ist. Zwischen Leitung zu: Patienten und der elektrischen Zelle 8 befindet sich der Isolator 9.The aerosol reaches the electrical cell 8, in which it is concentrated will. The line 10, which is provided with a mouthpiece at the end, leads to the patient is. Between the line to: patient and the electrical cell 8 is the Isolator 9.

Claims (2)

Patentansprüche 1. Verfahren und Vorrichtzing zur erzeugung eines aerosols, das von einem ratienten inhaliert werden kann und das nach Inhalation einen röntgenfähigen Kontrast ergibt, dadurch gekennzeichnet, daß in der Vorrichtung Druck und Temperatur so eingestellt werden, daß in der Zerstäubungsapparatur ein für die Inhalation und zur Darstellung des zentralen Bronchialsystems geeignetes Tropfenspektrum erzeugt wird.Claims 1. Method and Vorrichtzing for producing a aerosol that can be inhaled by a patient and that after inhalation results in a radiopaque contrast, characterized in that in the device Pressure and temperature can be adjusted so that a suitable for inhalation and for visualizing the central bronchial system Drop spectrum is generated. 2. Verfahren und Vorrichtung zur Erzeugung eines Aerosols dadurch gekennzeichnet, daß das in der Zerstäubungsapparatur erzeugte Aerosol in einer elektrischen Kammer durch Hochspannung konzentriert wird.2. Method and apparatus for generating an aerosol thereby characterized in that the aerosol generated in the nebulization apparatus in an electrical Chamber is concentrated by high voltage.
DE19803015279 1980-04-21 1980-04-21 X=Ray contrast agent aerosol for inhalation - in radiography of the central bronchial system not requiring patient anaesthesia Withdrawn DE3015279A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DE19803015279 DE3015279A1 (en) 1980-04-21 1980-04-21 X=Ray contrast agent aerosol for inhalation - in radiography of the central bronchial system not requiring patient anaesthesia

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19803015279 DE3015279A1 (en) 1980-04-21 1980-04-21 X=Ray contrast agent aerosol for inhalation - in radiography of the central bronchial system not requiring patient anaesthesia

Publications (1)

Publication Number Publication Date
DE3015279A1 true DE3015279A1 (en) 1981-10-29

Family

ID=6100561

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19803015279 Withdrawn DE3015279A1 (en) 1980-04-21 1980-04-21 X=Ray contrast agent aerosol for inhalation - in radiography of the central bronchial system not requiring patient anaesthesia

Country Status (1)

Country Link
DE (1) DE3015279A1 (en)

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WO1998025662A1 (en) * 1996-12-12 1998-06-18 Resmed Limited Substance delivery in breathable gas supply system
US6237593B1 (en) 1993-12-03 2001-05-29 Resmed Limited Estimation of flow and detection of breathing CPAP treatment
US6336454B1 (en) 1997-05-16 2002-01-08 Resmed Limited Nasal ventilation as a treatment for stroke
US6357441B1 (en) 1996-07-26 2002-03-19 Resmed Limited Nasal mask and mask cushion therefor
US6363270B1 (en) 1995-04-11 2002-03-26 Resmed Limited Monitoring the occurrence of apneic and hypopneic arousals
US6397841B1 (en) 1997-06-18 2002-06-04 Resmed Limited Apparatus for supplying breathable gas
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