DE3771389D1 - Waesserige steroidformulierungen zur nasalen verabreichung. - Google Patents

Waesserige steroidformulierungen zur nasalen verabreichung.

Info

Publication number
DE3771389D1
DE3771389D1 DE8787107416T DE3771389T DE3771389D1 DE 3771389 D1 DE3771389 D1 DE 3771389D1 DE 8787107416 T DE8787107416 T DE 8787107416T DE 3771389 T DE3771389 T DE 3771389T DE 3771389 D1 DE3771389 D1 DE 3771389D1
Authority
DE
Germany
Prior art keywords
amount
nasal administration
effective amount
steroid formulations
aqueous
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE8787107416T
Other languages
English (en)
Inventor
Eric Joel Benjamin
Shabbir Tyabji Anik
Ya-Yin Tracy Lin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Syntex Pharmaceuticals International Ltd
Original Assignee
Syntex Pharmaceuticals International Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Syntex Pharmaceuticals International Ltd filed Critical Syntex Pharmaceuticals International Ltd
Application granted granted Critical
Publication of DE3771389D1 publication Critical patent/DE3771389D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0043—Nose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
DE8787107416T 1986-05-22 1987-05-21 Waesserige steroidformulierungen zur nasalen verabreichung. Expired - Lifetime DE3771389D1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/866,171 US4782047A (en) 1986-05-22 1986-05-22 Aqueous steroid formulations for nasal administration

Publications (1)

Publication Number Publication Date
DE3771389D1 true DE3771389D1 (de) 1991-08-22

Family

ID=25347059

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8787107416T Expired - Lifetime DE3771389D1 (de) 1986-05-22 1987-05-21 Waesserige steroidformulierungen zur nasalen verabreichung.

Country Status (19)

Country Link
US (1) US4782047A (de)
EP (1) EP0246652B1 (de)
JP (1) JP2521291B2 (de)
KR (1) KR950008308B1 (de)
AT (1) ATE65183T1 (de)
AU (1) AU609718B2 (de)
CA (1) CA1288048C (de)
DE (1) DE3771389D1 (de)
DK (1) DK175238B1 (de)
ES (1) ES2031467T3 (de)
FI (1) FI88459C (de)
GR (1) GR3002317T3 (de)
HK (1) HK39094A (de)
IE (1) IE60259B1 (de)
IL (1) IL82615A (de)
IT (1) IT1205667B (de)
NO (1) NO173365C (de)
NZ (1) NZ220394A (de)
ZA (1) ZA873663B (de)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4983595A (en) * 1986-05-22 1991-01-08 Syntex (U.S.A.) Inc. Aqueous steroid formulations for nasal administration
JPH0311016A (ja) * 1989-06-09 1991-01-18 Tokyo Tanabe Co Ltd ピリド［１，２―ａ］ピリミジン誘導体の水性製剤
GB9103824D0 (en) * 1991-02-23 1991-04-10 Fisons Ag Formulation
US5338732A (en) * 1991-06-18 1994-08-16 Bristol-Myers Squibb Company Megestrol acetate formulation
CN1098708C (zh) * 1993-10-21 2003-01-15 久光制药株式会社 经鼻吸收的组合物以及含有该组合物的经鼻吸收制剂
US5762917A (en) * 1994-09-27 1998-06-09 Virotex Corporation Method and composition for cleansing wounds with minimal cytotoxicity for minimal scarring
US5976573A (en) * 1996-07-03 1999-11-02 Rorer Pharmaceutical Products Inc. Aqueous-based pharmaceutical composition
US6241969B1 (en) * 1998-06-26 2001-06-05 Elan Corporation Plc Aqueous compositions containing corticosteroids for nasal and pulmonary delivery
US8466134B1 (en) 1998-06-26 2013-06-18 Athena Neurosciences, Inc. Aqueous compositions containing corticosteroids for nasal and pulmonary delivery
GB9918559D0 (en) * 1999-08-07 1999-10-06 Glaxo Wellcome Kk Novel pharmaceutical formulation
US20060083691A1 (en) * 2000-05-10 2006-04-20 Wermeling Daniel P Intranasal opioid compositions, delivery devices and methods of using same
US20040115133A1 (en) * 2000-05-10 2004-06-17 Wermeling Daniel P. Intranasal opioid compositions
US6610271B2 (en) * 2000-05-10 2003-08-26 University Of Kentucky Research Foundation System and method for intranasal administration of lorazepam
WO2002013886A2 (en) 2000-08-15 2002-02-21 University Of Kentucky Research Foundation Programmable multi-dose intranasal drug delivery device
US20040176359A1 (en) * 2001-02-20 2004-09-09 University Of Kentucky Research Foundation Intranasal Benzodiazepine compositions
GB2389530B (en) 2002-06-14 2007-01-10 Cipla Ltd Pharmaceutical compositions
CA2493764C (en) 2002-08-01 2011-05-24 Aesgen, Inc. Improved treatment of cancer with glutamine
US7148211B2 (en) * 2002-09-18 2006-12-12 Genzyme Corporation Formulation for lipophilic agents
US7404489B1 (en) 2003-03-04 2008-07-29 Qol Medical, Llc Cyanocobalamin low viscosity aqueous formulations for intranasal delivery
JP5238779B2 (ja) * 2003-04-25 2013-07-17 ロート製薬株式会社 点鼻剤
JP4632687B2 (ja) * 2003-04-25 2011-02-16 ロート製薬株式会社 点鼻剤
WO2005065185A2 (en) * 2003-12-24 2005-07-21 Collegium Pharmaceuticals, Inc. Temperature-stable formulations, and methods of development thereof
GB0400804D0 (en) 2004-01-14 2004-02-18 Innoscience Technology Bv Pharmaceutical compositions
US20060045850A1 (en) * 2004-08-30 2006-03-02 Qpharma, Llc Nasal delivery of cyclodextrin complexes of anti-inflammatory steroids
LT2486942T (lt) 2004-11-24 2019-01-25 Meda Pharmaceuticals Inc. Kompozicijos, apimančios azelastiną ir jų panaudojimo būdai
US20070111964A1 (en) 2005-08-17 2007-05-17 Fleming And Company, Pharmaceuticals Vitamin B12 nasal spray and method of use
KR100767976B1 (ko) 2006-08-25 2007-10-18 한국유나이티드제약 주식회사 비내 건조증에 효과적인 약제학적 조성물
EP3150230A1 (de) 2007-01-19 2017-04-05 Hananja Ehf Verfahren und zusammensetzungen zur abgabe eines therapeutischen mittels
US20080275030A1 (en) * 2007-01-19 2008-11-06 Sveinbjorn Gizurarson Methods and Compositions for the Delivery of a Therapeutic Agent
JP2011001317A (ja) * 2009-06-19 2011-01-06 Fumakilla Ltd 鼻用洗浄剤
US10953021B2 (en) 2013-03-15 2021-03-23 Lupin Limited Topical compositions of flunisolide and methods of treatment
JP6097787B2 (ja) * 2015-06-09 2017-03-15 パル ファーマシューティカル， インコーポレーテッド 鼻内送達用シアノコバラミン低粘度水性製剤
US11510859B2 (en) 2015-07-16 2022-11-29 Marinomed Biotech Ag Method for improving aqueous solubility of water-insoluble or slightly water-soluble drugs
EA036233B1 (ru) 2015-07-16 2020-10-16 Мариномед Биотек Аг Способ улучшения растворимости в воде лекарственных средств, нерастворимых или слаборастворимых в воде

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2989437A (en) * 1955-06-08 1961-06-20 Upjohn Co Anti-inflammatory and anti-bacterial decongestant nasal spray compositions
MX3864E (es) * 1975-05-27 1981-08-26 Syntex Corp Un proceso para prepara el compuesto cristalino 6-fluiro-11b 21-dihiroxi-16 17-isopropilidendioxipregna-1 4-dien-3 20-diona
DE2750090A1 (de) * 1976-11-19 1978-06-01 Sandoz Ag Neue verabreichungsformen fuer organische verbindungen
US4444762A (en) * 1980-04-04 1984-04-24 Nelson Research & Development Company Vehicle composition containing 1-substituted azacyclopentan-2-ones
US4344940A (en) * 1981-11-30 1982-08-17 E. R. Squibb & Sons, Inc. Steroid formulation containing dipotassium EDTA
US4603131A (en) * 1982-04-26 1986-07-29 Bernstein Joel E Method and composition for treating and preventing irritation of the mucous membranes of the nose

Also Published As

Publication number Publication date
NO173365B (no) 1993-08-30
US4782047A (en) 1988-11-01
FI88459B (fi) 1993-02-15
EP0246652B1 (de) 1991-07-17
NO872127D0 (no) 1987-05-21
FI872231A (fi) 1987-11-23
IL82615A (en) 1991-11-21
AU609718B2 (en) 1991-05-09
NO173365C (no) 1993-12-08
GR3002317T3 (en) 1992-12-30
IE60259B1 (en) 1994-06-29
DK175238B1 (da) 2004-07-19
EP0246652A2 (de) 1987-11-25
ATE65183T1 (de) 1991-08-15
IT8720621A0 (it) 1987-05-21
ZA873663B (en) 1988-12-28
DK258687A (da) 1987-11-23
AU7327387A (en) 1987-11-26
JPS62283927A (ja) 1987-12-09
NO872127L (no) 1987-11-23
JP2521291B2 (ja) 1996-08-07
FI872231A0 (fi) 1987-05-21
HK39094A (en) 1994-04-29
KR870010862A (ko) 1987-12-18
NZ220394A (en) 1990-04-26
IE871335L (en) 1987-11-22
KR950008308B1 (ko) 1995-07-27
FI88459C (fi) 1993-05-25
IT1205667B (it) 1989-03-31
EP0246652A3 (en) 1988-02-03
DK258687D0 (da) 1987-05-21
IL82615A0 (en) 1987-11-30
CA1288048C (en) 1991-08-27
ES2031467T3 (es) 1992-12-16

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8328 Change in the person/name/address of the agent

Free format text: BARZ, P., DIPL.-CHEM. DR.RER.NAT., PAT.-ANW., 80803 MUENCHEN