DE3852383D1 - Gereinigtes follikel-stimulierendes hormon. - Google Patents

Gereinigtes follikel-stimulierendes hormon.

Info

Publication number
DE3852383D1
DE3852383D1 DE3852383T DE3852383T DE3852383D1 DE 3852383 D1 DE3852383 D1 DE 3852383D1 DE 3852383 T DE3852383 T DE 3852383T DE 3852383 T DE3852383 T DE 3852383T DE 3852383 D1 DE3852383 D1 DE 3852383D1
Authority
DE
Germany
Prior art keywords
stimulating hormone
purified follicle
follicle
purified
hormone
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE3852383T
Other languages
English (en)
Other versions
DE3852383T2 (de
Inventor
Giuseppe Arpaia
Serenella Serani
Antonino Sirna
Stefano Villa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Serono SpA
Original Assignee
Istituto di Ricerca Cesare Serono SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=11264576&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE3852383(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Istituto di Ricerca Cesare Serono SpA filed Critical Istituto di Ricerca Cesare Serono SpA
Publication of DE3852383D1 publication Critical patent/DE3852383D1/de
Application granted granted Critical
Publication of DE3852383T2 publication Critical patent/DE3852383T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/59—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g. HCG; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/24—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g. HCG; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/26—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/11—Gonadotropin; related peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Endocrinology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Reproductive Health (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Veterinary Medicine (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Toxicology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gynecology & Obstetrics (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DE3852383T 1987-06-26 1988-06-24 Gereinigtes follikel-stimulierendes hormon. Expired - Lifetime DE3852383T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT8748110A IT1206302B (it) 1987-06-26 1987-06-26 Ormone follicolo-stimolante urinario
PCT/IT1988/000048 WO1988010270A1 (en) 1987-06-26 1988-06-24 Urinary follicle stimulating hormone

Publications (2)

Publication Number Publication Date
DE3852383D1 true DE3852383D1 (de) 1995-01-19
DE3852383T2 DE3852383T2 (de) 1995-04-20

Family

ID=11264576

Family Applications (1)

Application Number Title Priority Date Filing Date
DE3852383T Expired - Lifetime DE3852383T2 (de) 1987-06-26 1988-06-24 Gereinigtes follikel-stimulierendes hormon.

Country Status (26)

Country Link
US (3) US5128453A (de)
EP (1) EP0322438B1 (de)
JP (1) JP2523843B2 (de)
KR (1) KR0156565B1 (de)
CN (2) CN1031714C (de)
AR (1) AR243241A1 (de)
AT (1) ATE115148T1 (de)
AU (1) AU615930B2 (de)
CA (1) CA1340649C (de)
DE (1) DE3852383T2 (de)
DK (1) DK173349B1 (de)
ES (1) ES2009948A6 (de)
FI (1) FI96608C (de)
GE (2) GEP19971042B (de)
GR (1) GR1003186B (de)
HK (1) HK143195A (de)
IL (1) IL86847A (de)
IT (1) IT1206302B (de)
LT (2) LT3999B (de)
LV (2) LV10628B (de)
MX (1) MX9203471A (de)
NO (1) NO177498C (de)
RU (2) RU2105012C1 (de)
UA (1) UA19101A (de)
WO (1) WO1988010270A1 (de)
ZA (1) ZA884492B (de)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1206302B (it) * 1987-06-26 1989-04-14 Serono Cesare Ist Ricerca Ormone follicolo-stimolante urinario
US5087615A (en) * 1989-03-17 1992-02-11 Applied Research Systems Ars Holding N.V. Novel method of ovulation induction in humans
IT1250075B (it) * 1991-12-18 1995-03-30 Serono Cesare Ist Ricerca Composizioni farmaceutiche contenenti gonadotropine.
IT1270866B (it) * 1993-03-10 1997-05-13 Eniricerche Spa Vettore ricombinante e suo impiego per la preparazione esocellulare di anticorpi in forma di singola molecola da bacillus subtilis
US6737515B2 (en) * 1993-11-19 2004-05-18 Washington University Follicle stimulating hormone-glycosylation analogs
US6162905A (en) * 1996-11-07 2000-12-19 Ibsa Institut Biochimique S.A. FSH and LH separation and purification process
TW518235B (en) * 1997-01-15 2003-01-21 Akzo Nobel Nv A gonadotropin-containing pharmaceutical composition with improved stability on prolong storage
US5990288A (en) * 1997-10-21 1999-11-23 Vitro Diagnostics, Inc. Method for purifying FSH
US6414123B1 (en) 1997-10-21 2002-07-02 Vitro Diagnostics, Inc. Method for purifying FSH
US20030166525A1 (en) * 1998-07-23 2003-09-04 Hoffmann James Arthur FSH Formulation
PL346127A1 (en) * 1998-07-23 2002-01-28 Lilly Co Eli Fsh and fsh variant formulations, products and methods
US7112341B1 (en) 1999-04-13 2006-09-26 Nektar Therapeutics Pulmonary administration of dry powder formulations for treating infertility
GB9924351D0 (en) 1999-10-14 1999-12-15 Brennan Frank Immunomodulation methods and compositions
JP2001349892A (ja) * 2000-04-03 2001-12-21 Unilever Nv 検査方法及びデバイス
AU6469401A (en) * 2000-05-19 2001-11-26 Serono Reproductive Biology In Pharmaceutically active compounds and methods of use
ES2281458T3 (es) * 2000-12-21 2007-10-01 Nektar Therapeutics Composiciones de polvo estables en almacenamiento del receptor de interleucina 4.
EA007030B1 (ru) * 2001-10-22 2006-06-30 Апплайд Резеч Системз Арс Холдинг Н.В. Гонадотропины для фолликулогенеза
IL161541A0 (en) 2001-10-22 2004-09-27 Applied Research Systems Mutant glycoproteins
AU2003299124A1 (en) 2002-09-20 2004-04-23 Laboratoires Serono Sa Piperazine derivatives and methods of use
CA2517487A1 (en) * 2003-04-01 2004-10-14 Applied Research Systems Ars Holding N.V. Inhibitors of phosphodiesterases in infertility
MXPA05010635A (es) * 2003-04-02 2005-12-12 Ares Trading Sa Formulaciones farmaceuticas liquidas de hormona estimulante de foliculos y hormona luteinizante junto con un surfactante no ionico.
EP1638595B1 (de) * 2003-06-20 2013-03-20 Ares Trading S.A. Gefriergetrocknete fsh / lh formulierungen
EA008924B1 (ru) * 2003-12-22 2007-08-31 Арес Трейдинг С.А. Способ очистки фсг
US20070270339A1 (en) * 2004-04-23 2007-11-22 Serono, Inc. Use of GPCR54 Ligands for the Treatment of Infertility
ES2312037T3 (es) * 2004-11-09 2009-02-16 Ares Trading S.A. Metodo para puruficar fsh.
KR20080044836A (ko) 2005-07-15 2008-05-21 라보라뚜와르 세로노 에스. 에이. 자궁내막증 치료용 ｊｎｋ 억제제
BRPI0613042A2 (pt) 2005-07-15 2010-12-14 Serono Lab inibidores de jnk para o tratamento de endometriose
US20080219952A1 (en) 2005-08-26 2008-09-11 Ares Trading S.A. Process For the Preparation of Glycosylated Interferon Beta
WO2007030362A1 (en) 2005-09-07 2007-03-15 Laboratoires Serono Sa. Ikk inhibitors for the treatment of endometriosis
PL1951395T3 (pl) * 2005-09-14 2012-08-31 Ares Trading Sa Sposób ilościowego oznaczania poloksamerów
US8604175B2 (en) 2005-12-09 2013-12-10 Ares Trading S.A. Method for purifying FSH or a FSH mutant
JP2010524508A (ja) * 2007-04-27 2010-07-22 ダウ グローバル テクノロジーズ インコーポレイティド 可溶性組換え二十面体ウイルス様粒子の生産及びインビボ組織化の改善
NZ581702A (en) 2007-06-28 2011-10-28 Biogenerix Ag Follicle stimulating hormone producing cell clone
DE202009009905U1 (de) 2008-02-08 2009-10-29 Biogenerix Ag Flüssig-Formulierung von FSH
TWI488640B (zh) 2008-04-16 2015-06-21 Ferring Int Ct Sa 藥學製劑
CN101269215B (zh) * 2008-05-15 2011-03-23 上海天伟生物制药有限公司 一种糖蛋白激素组合物
JP2009273427A (ja) 2008-05-16 2009-11-26 Jcr Pharmaceuticals Co Ltd 組換え体ヒトｆｓｈの製造方法
WO2010115586A2 (en) 2009-04-01 2010-10-14 Biogenerix Ag Method for purifying recombinant fsh
TWI532495B (zh) 2009-10-05 2016-05-11 菲瑞茵國際中心股份有限公司 藥學製劑
EP2325194A1 (de) 2009-11-24 2011-05-25 Glycotope GmbH Verfahren zur Reinigung von Glykoproteinen
PL2691119T3 (pl) 2011-03-31 2019-01-31 Ferring B.V. Preparat farmaceutyczny
CN103509121B (zh) 2012-11-22 2015-01-28 苏州康宁杰瑞生物科技有限公司 一种fsh融合蛋白及其制备方法和用途
US10537723B2 (en) 2014-09-11 2020-01-21 Hisamitsu Pharmaceutical Co., Inc. Microneedle device
CN107106658B (zh) 2014-10-27 2021-07-09 久光制药株式会社 含有基因重组型卵泡刺激激素的微针装置
WO2018069831A2 (en) * 2016-10-11 2018-04-19 Abresearch S.R.L. Ligands of the fsh hormone receptor in the diagnosis and treatment of tumors
CN111349154A (zh) * 2018-12-21 2020-06-30 江苏众红生物工程创药研究院有限公司 一种重组人促卵泡激素及其制备方法和药物应用
CN114867741A (zh) * 2019-12-26 2022-08-05 株式会社Lg化学 纯化促卵泡激素的方法
CN113583125B (zh) * 2021-07-09 2022-09-20 苏州晟济药业有限公司 抗体以及包含其的结合剂、免疫吸附材料及其应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3852422A (en) * 1971-06-26 1974-12-03 Serono Ist Farm Long-active gonadotropins
SU618113A1 (ru) * 1976-11-19 1978-08-05 Всесоюзный научно-исследовательский институт технологии кровезаменителей и гормональных препаратов Способ получени фолликулостимулирующего гормона
US4923805A (en) * 1983-11-02 1990-05-08 Integrated Genetics, Inc. Fsh
EP0161063B1 (de) * 1984-04-03 1991-07-24 Serono Laboratories, Inc. Verfahren zur Herbeiführung der Ovulation
US4845077A (en) * 1984-04-03 1989-07-04 Serono Laboratories, Inc. Method of inducing ovulation
GB8510177D0 (en) 1985-04-22 1985-05-30 Public Health Laborotory Servi Isolating pituitary glycoprotein hormones
GB2174600B (en) * 1985-05-10 1989-12-20 Univ Melbourne Induction of ovulation in mares
IT1206302B (it) * 1987-06-26 1989-04-14 Serono Cesare Ist Ricerca Ormone follicolo-stimolante urinario

Also Published As

Publication number Publication date
FI890893A0 (fi) 1989-02-24
GEP19981274B (en) 1998-05-06
NO890805L (no) 1989-02-24
CN1117873A (zh) 1996-03-06
CN1069062C (zh) 2001-08-01
IL86847A0 (en) 1988-11-30
IT1206302B (it) 1989-04-14
AU615930B2 (en) 1988-06-24
US5840857A (en) 1998-11-24
LT4018B (en) 1996-08-26
RU2059412C1 (ru) 1996-05-10
LTIP1652A (en) 1995-08-25
US5128453A (en) 1992-07-07
GR880100418A (el) 1989-03-08
CA1340649C (en) 1999-07-13
JP2523843B2 (ja) 1996-08-14
DK89989D0 (da) 1989-02-24
IL86847A (en) 1997-11-20
FI96608B (fi) 1996-04-15
ATE115148T1 (de) 1994-12-15
DK89989A (da) 1989-02-24
IT8748110A0 (it) 1987-06-26
FI96608C (fi) 1996-07-25
WO1988010270A1 (en) 1988-12-29
MX9203471A (es) 1992-09-01
GEP19971042B (en) 1997-06-13
AR243241A1 (es) 1993-07-30
LV10628A (lv) 1995-04-20
NO177498B (no) 1995-06-19
AU1962088A (en) 1989-01-19
LV10196A (lv) 1994-10-20
FI890893A (fi) 1989-02-24
LV10628B (en) 1995-10-20
NO890805D0 (no) 1989-02-24
EP0322438A1 (de) 1989-07-05
CN1030589A (zh) 1989-01-25
KR890701626A (ko) 1989-12-21
ZA884492B (en) 1989-05-30
NO177498C (no) 1995-09-27
UA19101A (uk) 1997-12-25
US5767067A (en) 1998-06-16
EP0322438B1 (de) 1994-12-07
LT3999B (en) 1996-06-25
HK143195A (en) 1995-09-15
DK173349B1 (da) 2000-08-07
LV10196B (en) 1995-04-20
LTIP1654A (en) 1995-08-25
RU2105012C1 (ru) 1998-02-20
GR1003186B (el) 1999-09-01
KR0156565B1 (ko) 1998-10-15
ES2009948A6 (es) 1989-10-16
JPH02500840A (ja) 1990-03-22
CN1031714C (zh) 1996-05-01
DE3852383T2 (de) 1995-04-20

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8310 Action for declaration of annulment
8312 Partial invalidation
8327 Change in the person/name/address of the patent owner

Owner name: INDUSTRIA FARMACEUTICA SERONO S.P.A., ROM/ROMA, IT