DE3852383T2 - Gereinigtes follikel-stimulierendes hormon. - Google Patents

Gereinigtes follikel-stimulierendes hormon.

Info

Publication number
DE3852383T2
DE3852383T2 DE3852383T DE3852383T DE3852383T2 DE 3852383 T2 DE3852383 T2 DE 3852383T2 DE 3852383 T DE3852383 T DE 3852383T DE 3852383 T DE3852383 T DE 3852383T DE 3852383 T2 DE3852383 T2 DE 3852383T2
Authority
DE
Germany
Prior art keywords
stimulating hormone
purified follicle
follicle
purified
hormone
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE3852383T
Other languages
English (en)
Other versions
DE3852383D1 (de
Inventor
Giuseppe Arpaia
Serenella Serani
Antonino Sirna
Stefano Villa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Serono SpA
Original Assignee
Istituto di Ricerca Cesare Serono SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=11264576&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE3852383(T2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Istituto di Ricerca Cesare Serono SpA filed Critical Istituto di Ricerca Cesare Serono SpA
Application granted granted Critical
Publication of DE3852383D1 publication Critical patent/DE3852383D1/de
Publication of DE3852383T2 publication Critical patent/DE3852383T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/59—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g. HCG; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/24—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g. HCG; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/26—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/11—Gonadotropin; related peptides
DE3852383T 1987-06-26 1988-06-24 Gereinigtes follikel-stimulierendes hormon. Expired - Lifetime DE3852383T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT8748110A IT1206302B (it) 1987-06-26 1987-06-26 Ormone follicolo-stimolante urinario
PCT/IT1988/000048 WO1988010270A1 (en) 1987-06-26 1988-06-24 Urinary follicle stimulating hormone

Publications (2)

Publication Number Publication Date
DE3852383D1 DE3852383D1 (de) 1995-01-19
DE3852383T2 true DE3852383T2 (de) 1995-04-20

Family

ID=11264576

Family Applications (1)

Application Number Title Priority Date Filing Date
DE3852383T Expired - Lifetime DE3852383T2 (de) 1987-06-26 1988-06-24 Gereinigtes follikel-stimulierendes hormon.

Country Status (26)

Country Link
US (3) US5128453A (de)
EP (1) EP0322438B1 (de)
JP (1) JP2523843B2 (de)
KR (1) KR0156565B1 (de)
CN (2) CN1031714C (de)
AR (1) AR243241A1 (de)
AT (1) ATE115148T1 (de)
AU (1) AU615930B2 (de)
CA (1) CA1340649C (de)
DE (1) DE3852383T2 (de)
DK (1) DK173349B1 (de)
ES (1) ES2009948A6 (de)
FI (1) FI96608C (de)
GE (2) GEP19971042B (de)
GR (1) GR1003186B (de)
HK (1) HK143195A (de)
IL (1) IL86847A (de)
IT (1) IT1206302B (de)
LT (2) LT3999B (de)
LV (2) LV10628B (de)
MX (1) MX9203471A (de)
NO (1) NO177498C (de)
RU (2) RU2059412C1 (de)
UA (1) UA19101A (de)
WO (1) WO1988010270A1 (de)
ZA (1) ZA884492B (de)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1206302B (it) * 1987-06-26 1989-04-14 Serono Cesare Ist Ricerca Ormone follicolo-stimolante urinario
US5087615A (en) * 1989-03-17 1992-02-11 Applied Research Systems Ars Holding N.V. Novel method of ovulation induction in humans
IT1250075B (it) * 1991-12-18 1995-03-30 Serono Cesare Ist Ricerca Composizioni farmaceutiche contenenti gonadotropine.
IT1270866B (it) * 1993-03-10 1997-05-13 Eniricerche Spa Vettore ricombinante e suo impiego per la preparazione esocellulare di anticorpi in forma di singola molecola da bacillus subtilis
US6737515B2 (en) * 1993-11-19 2004-05-18 Washington University Follicle stimulating hormone-glycosylation analogs
US6162905A (en) * 1996-11-07 2000-12-19 Ibsa Institut Biochimique S.A. FSH and LH separation and purification process
TW518235B (en) * 1997-01-15 2003-01-21 Akzo Nobel Nv A gonadotropin-containing pharmaceutical composition with improved stability on prolong storage
US6414123B1 (en) * 1997-10-21 2002-07-02 Vitro Diagnostics, Inc. Method for purifying FSH
US5990288A (en) * 1997-10-21 1999-11-23 Vitro Diagnostics, Inc. Method for purifying FSH
NZ508874A (en) * 1998-07-23 2004-03-26 Lilly Co Eli FSH and FSH variant formulations, products and methods of treating infertility.
US20030166525A1 (en) * 1998-07-23 2003-09-04 Hoffmann James Arthur FSH Formulation
CA2369262A1 (en) 1999-04-13 2000-10-19 Sudha Nagarajan Pulmonary administration of dry powder formulations for treating infertility
GB9924351D0 (en) 1999-10-14 1999-12-15 Brennan Frank Immunomodulation methods and compositions
JP2001349892A (ja) * 2000-04-03 2001-12-21 Unilever Nv 検査方法及びデバイス
ATE302002T1 (de) * 2000-05-19 2005-09-15 Applied Research Systems Verwendung von pyrazolderivaten zur behandlung von unfruchtbarkeit
US6896906B2 (en) * 2000-12-21 2005-05-24 Nektar Therapeutics Storage stable powder compositions of interleukin-4 receptor
US20050085412A1 (en) * 2001-10-22 2005-04-21 Applied Research Systems Ars Holding N.V. Gonadotrophins for folliculogenesis
CA2469724A1 (en) 2001-10-22 2004-06-17 Applied Research Systems Ars Holding N.V. Mutant glycoproteins
ES2399047T3 (es) * 2002-09-20 2013-03-25 Merck Serono Sa Derivados de piperazina y procedimiento de uso
EA200501548A1 (ru) * 2003-04-01 2006-02-24 Апплайд Резеч Системз Арс Холдинг Н.В. Ингибиторы фосфодиэстераз при бесплодии
KR101105486B1 (ko) * 2003-04-02 2012-01-13 아레스 트레이딩 에스.에이. Ｆｓｈ 및 ｌｈ과 비이온성 계면활성제의 액상 약제학적 제제
WO2004112826A1 (en) * 2003-06-20 2004-12-29 Ares Trading Sa Freeze-dried fsh / lh formulations
DE602004023757D1 (de) * 2003-12-22 2009-12-03 Ares Trading Sa Methode zur reinigung von fsh
US20070270339A1 (en) * 2004-04-23 2007-11-22 Serono, Inc. Use of GPCR54 Ligands for the Treatment of Infertility
ES2312037T3 (es) 2004-11-09 2009-02-16 Ares Trading S.A. Metodo para puruficar fsh.
KR20080044836A (ko) 2005-07-15 2008-05-21 라보라뚜와르 세로노 에스. 에이. 자궁내막증 치료용 ｊｎｋ 억제제
BRPI0613042A2 (pt) 2005-07-15 2010-12-14 Serono Lab inibidores de jnk para o tratamento de endometriose
WO2007022799A1 (en) 2005-08-26 2007-03-01 Ares Trading S.A. Process for the preparation of glycosylated interferon beta
KR20080052650A (ko) 2005-09-07 2008-06-11 라보라토리스 세로노 에스.에이. 자궁내막증 치료용 ｉｋｋ 저해제
US7866203B2 (en) * 2005-09-14 2011-01-11 Ares Trading S.A. Method for the quantitative determination of poloxamers
US8604175B2 (en) 2005-12-09 2013-12-10 Ares Trading S.A. Method for purifying FSH or a FSH mutant
US20090093019A1 (en) * 2007-04-27 2009-04-09 Phelps Jamie P Production and in vivo assembly of soluble recombinant icosahedral virus-like particles
NZ581702A (en) 2007-06-28 2011-10-28 Biogenerix Ag Follicle stimulating hormone producing cell clone
ME01337B (me) 2008-02-08 2013-12-20 Biogenerix Ag Tečni preparat fsh
TWI488640B (zh) 2008-04-16 2015-06-21 Ferring Int Ct Sa 藥學製劑
CN101269215B (zh) * 2008-05-15 2011-03-23 上海天伟生物制药有限公司 一种糖蛋白激素组合物
JP2009273427A (ja) 2008-05-16 2009-11-26 Jcr Pharmaceuticals Co Ltd 組換え体ヒトｆｓｈの製造方法
CA2755927A1 (en) 2009-04-01 2010-10-14 Biogenerix Ag Method for purifying recombinant fsh
TWI604850B (zh) 2009-10-05 2017-11-11 菲瑞茵國際中心股份有限公司 藥學製劑
EP2325194A1 (de) 2009-11-24 2011-05-25 Glycotope GmbH Verfahren zur Reinigung von Glykoproteinen
ES2693273T3 (es) 2011-03-31 2018-12-10 Ferring B.V. Preparación farmacéutica
CN103509121B (zh) 2012-11-22 2015-01-28 苏州康宁杰瑞生物科技有限公司 一种fsh融合蛋白及其制备方法和用途
US10537723B2 (en) 2014-09-11 2020-01-21 Hisamitsu Pharmaceutical Co., Inc. Microneedle device
WO2016067956A1 (ja) 2014-10-27 2016-05-06 久光製薬株式会社 遺伝子組換型卵胞刺激ホルモンを含有するマイクロニードルデバイス
RU2755000C2 (ru) * 2016-10-11 2021-09-08 Онкогреен Тхерапеутикс Са Лиганды к рецептору фолликулостимулирующего гормона (FSH) в диагностике и лечении опухолей
CN111349154A (zh) * 2018-12-21 2020-06-30 江苏众红生物工程创药研究院有限公司 一种重组人促卵泡激素及其制备方法和药物应用
MX2022006383A (es) * 2019-12-26 2022-06-24 Lg Chemical Ltd Procedimiento de purificacion de la hormona foliculo-estimulante.
CN116120449A (zh) * 2021-07-09 2023-05-16 苏州晟济药业有限公司 抗体以及包含其的结合剂、免疫吸附材料及其应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3852422A (en) * 1971-06-26 1974-12-03 Serono Ist Farm Long-active gonadotropins
SU618113A1 (ru) * 1976-11-19 1978-08-05 Всесоюзный научно-исследовательский институт технологии кровезаменителей и гормональных препаратов Способ получени фолликулостимулирующего гормона
US4923805A (en) * 1983-11-02 1990-05-08 Integrated Genetics, Inc. Fsh
JPS6176421A (ja) * 1984-04-03 1986-04-18 セロノ　ラボラトリ−ズ　インコ−ポレイテツド 排卵誘発方法およびインビトロ受精方法
US4845077A (en) * 1984-04-03 1989-07-04 Serono Laboratories, Inc. Method of inducing ovulation
GB8510177D0 (en) * 1985-04-22 1985-05-30 Public Health Laborotory Servi Isolating pituitary glycoprotein hormones
GB2174600B (en) * 1985-05-10 1989-12-20 Univ Melbourne Induction of ovulation in mares
IT1206302B (it) * 1987-06-26 1989-04-14 Serono Cesare Ist Ricerca Ormone follicolo-stimolante urinario

Also Published As

Publication number Publication date
US5128453A (en) 1992-07-07
DK89989A (da) 1989-02-24
WO1988010270A1 (en) 1988-12-29
CN1069062C (zh) 2001-08-01
IT8748110A0 (it) 1987-06-26
IT1206302B (it) 1989-04-14
JPH02500840A (ja) 1990-03-22
AU1962088A (en) 1989-01-19
LT3999B (en) 1996-06-25
US5767067A (en) 1998-06-16
FI96608C (fi) 1996-07-25
LV10628B (en) 1995-10-20
IL86847A0 (en) 1988-11-30
RU2059412C1 (ru) 1996-05-10
JP2523843B2 (ja) 1996-08-14
FI890893A0 (fi) 1989-02-24
GR880100418A (el) 1989-03-08
LTIP1652A (en) 1995-08-25
LV10628A (lv) 1995-04-20
IL86847A (en) 1997-11-20
US5840857A (en) 1998-11-24
CN1117873A (zh) 1996-03-06
CN1030589A (zh) 1989-01-25
GR1003186B (el) 1999-09-01
CA1340649C (en) 1999-07-13
AR243241A1 (es) 1993-07-30
GEP19971042B (en) 1997-06-13
EP0322438A1 (de) 1989-07-05
ES2009948A6 (es) 1989-10-16
ZA884492B (en) 1989-05-30
LV10196B (en) 1995-04-20
LV10196A (lv) 1994-10-20
DE3852383D1 (de) 1995-01-19
NO177498B (no) 1995-06-19
NO890805L (no) 1989-02-24
FI890893A (fi) 1989-02-24
HK143195A (en) 1995-09-15
LT4018B (en) 1996-08-26
ATE115148T1 (de) 1994-12-15
AU615930B2 (en) 1988-06-24
LTIP1654A (en) 1995-08-25
RU2105012C1 (ru) 1998-02-20
FI96608B (fi) 1996-04-15
NO890805D0 (no) 1989-02-24
CN1031714C (zh) 1996-05-01
MX9203471A (es) 1992-09-01
DK89989D0 (da) 1989-02-24
DK173349B1 (da) 2000-08-07
KR0156565B1 (ko) 1998-10-15
GEP19981274B (en) 1998-05-06
EP0322438B1 (de) 1994-12-07
KR890701626A (ko) 1989-12-21
NO177498C (no) 1995-09-27
UA19101A (uk) 1997-12-25

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8310 Action for declaration of annulment
8312 Partial invalidation
8327 Change in the person/name/address of the patent owner

Owner name: INDUSTRIA FARMACEUTICA SERONO S.P.A., ROM/ROMA, IT