DE3852383T2 - Gereinigtes follikel-stimulierendes hormon. - Google Patents
Gereinigtes follikel-stimulierendes hormon.Info
- Publication number
- DE3852383T2 DE3852383T2 DE3852383T DE3852383T DE3852383T2 DE 3852383 T2 DE3852383 T2 DE 3852383T2 DE 3852383 T DE3852383 T DE 3852383T DE 3852383 T DE3852383 T DE 3852383T DE 3852383 T2 DE3852383 T2 DE 3852383T2
- Authority
- DE
- Germany
- Prior art keywords
- stimulating hormone
- purified follicle
- follicle
- purified
- hormone
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/59—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g. HCG; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/24—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g. HCG; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/26—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/11—Gonadotropin; related peptides
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT8748110A IT1206302B (it) | 1987-06-26 | 1987-06-26 | Ormone follicolo-stimolante urinario |
PCT/IT1988/000048 WO1988010270A1 (en) | 1987-06-26 | 1988-06-24 | Urinary follicle stimulating hormone |
Publications (2)
Publication Number | Publication Date |
---|---|
DE3852383D1 DE3852383D1 (de) | 1995-01-19 |
DE3852383T2 true DE3852383T2 (de) | 1995-04-20 |
Family
ID=11264576
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE3852383T Expired - Lifetime DE3852383T2 (de) | 1987-06-26 | 1988-06-24 | Gereinigtes follikel-stimulierendes hormon. |
Country Status (26)
Country | Link |
---|---|
US (3) | US5128453A (de) |
EP (1) | EP0322438B1 (de) |
JP (1) | JP2523843B2 (de) |
KR (1) | KR0156565B1 (de) |
CN (2) | CN1031714C (de) |
AR (1) | AR243241A1 (de) |
AT (1) | ATE115148T1 (de) |
AU (1) | AU615930B2 (de) |
CA (1) | CA1340649C (de) |
DE (1) | DE3852383T2 (de) |
DK (1) | DK173349B1 (de) |
ES (1) | ES2009948A6 (de) |
FI (1) | FI96608C (de) |
GE (2) | GEP19971042B (de) |
GR (1) | GR1003186B (de) |
HK (1) | HK143195A (de) |
IL (1) | IL86847A (de) |
IT (1) | IT1206302B (de) |
LT (2) | LT3999B (de) |
LV (2) | LV10628B (de) |
MX (1) | MX9203471A (de) |
NO (1) | NO177498C (de) |
RU (2) | RU2059412C1 (de) |
UA (1) | UA19101A (de) |
WO (1) | WO1988010270A1 (de) |
ZA (1) | ZA884492B (de) |
Families Citing this family (48)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1206302B (it) * | 1987-06-26 | 1989-04-14 | Serono Cesare Ist Ricerca | Ormone follicolo-stimolante urinario |
US5087615A (en) * | 1989-03-17 | 1992-02-11 | Applied Research Systems Ars Holding N.V. | Novel method of ovulation induction in humans |
IT1250075B (it) * | 1991-12-18 | 1995-03-30 | Serono Cesare Ist Ricerca | Composizioni farmaceutiche contenenti gonadotropine. |
IT1270866B (it) * | 1993-03-10 | 1997-05-13 | Eniricerche Spa | Vettore ricombinante e suo impiego per la preparazione esocellulare di anticorpi in forma di singola molecola da bacillus subtilis |
US6737515B2 (en) * | 1993-11-19 | 2004-05-18 | Washington University | Follicle stimulating hormone-glycosylation analogs |
US6162905A (en) * | 1996-11-07 | 2000-12-19 | Ibsa Institut Biochimique S.A. | FSH and LH separation and purification process |
IL122732A0 (en) * | 1997-01-15 | 1998-08-16 | Akzo Nobel Nv | Liquid gonadotropin-containing formulation its preparation and a device containing same |
US5990288A (en) * | 1997-10-21 | 1999-11-23 | Vitro Diagnostics, Inc. | Method for purifying FSH |
US6414123B1 (en) * | 1997-10-21 | 2002-07-02 | Vitro Diagnostics, Inc. | Method for purifying FSH |
PL346127A1 (en) * | 1998-07-23 | 2002-01-28 | Lilly Co Eli | Fsh and fsh variant formulations, products and methods |
US20030166525A1 (en) * | 1998-07-23 | 2003-09-04 | Hoffmann James Arthur | FSH Formulation |
EP1169053A1 (de) | 1999-04-13 | 2002-01-09 | Inhale Therapeutic Systems, Inc. | Verabreichung von trockenpulverformulierungen über die lungen zur behandlung der unfruchtbarkeit |
GB9924351D0 (en) | 1999-10-14 | 1999-12-15 | Brennan Frank | Immunomodulation methods and compositions |
JP2001349892A (ja) * | 2000-04-03 | 2001-12-21 | Unilever Nv | 検査方法及びデバイス |
ATE302002T1 (de) * | 2000-05-19 | 2005-09-15 | Applied Research Systems | Verwendung von pyrazolderivaten zur behandlung von unfruchtbarkeit |
CA2432175C (en) * | 2000-12-21 | 2010-08-10 | Jayne E. Hastedt | Storage stable powder compositions of interleukin-4 receptor |
CN1608078B (zh) * | 2001-10-22 | 2012-07-25 | 默克雪兰诺有限公司 | 用于卵泡生成的促性腺激素 |
WO2004050679A2 (en) | 2001-10-22 | 2004-06-17 | Applied Research Systems Ars Holding N.V. | Mutant glycoproteins |
ES2399047T3 (es) | 2002-09-20 | 2013-03-25 | Merck Serono Sa | Derivados de piperazina y procedimiento de uso |
KR20050115331A (ko) * | 2003-04-01 | 2005-12-07 | 어플라이드 리서치 시스템스 에이알에스 홀딩 엔.브이. | 불임증 포스포디에스터라제의 억제제 |
PL1610822T5 (pl) * | 2003-04-02 | 2019-05-31 | Ares Trading Sa | Płynne formulacje farmaceutyczne FSH i LH z niejonowym surfaktantem |
AU2004248931B2 (en) * | 2003-06-20 | 2009-07-16 | Ares Trading S.A. | Freeze-dried FSH / LH formulations |
CA2544333A1 (en) * | 2003-12-22 | 2005-07-14 | Ares Trading S.A. | Method for purifying fsh |
US20070270339A1 (en) * | 2004-04-23 | 2007-11-22 | Serono, Inc. | Use of GPCR54 Ligands for the Treatment of Infertility |
KR101173717B1 (ko) * | 2004-11-09 | 2012-08-13 | 아레스 트레이딩 에스.에이. | Fsh를 정제하는 방법 |
BRPI0613042A2 (pt) | 2005-07-15 | 2010-12-14 | Serono Lab | inibidores de jnk para o tratamento de endometriose |
KR20080044836A (ko) | 2005-07-15 | 2008-05-21 | 라보라뚜와르 세로노 에스. 에이. | 자궁내막증 치료용 jnk 억제제 |
JP4944112B2 (ja) | 2005-08-26 | 2012-05-30 | アレス トレーディング ソシエテ アノニム | グリコシル化されたインターフェロンベータの調製方法 |
CN101304736A (zh) | 2005-09-07 | 2008-11-12 | 雪兰诺实验室公司 | 治疗子宫内膜异位症的ikk抑制剂 |
CA2612613A1 (en) * | 2005-09-14 | 2007-03-22 | Mara Rossi | Method for the determination of poloxamers |
EP1960419B1 (de) | 2005-12-09 | 2016-03-16 | Ares Trading S.A. | Verfahren zur aufreinigung von fsh oder einer fsh-mutante |
CN101784655A (zh) * | 2007-04-27 | 2010-07-21 | 菲尼克斯股份有限公司 | 可溶性重组二十面体病毒样颗粒的改良生成和体内装配 |
SI2170942T1 (sl) | 2007-06-28 | 2013-12-31 | Biogenerix Ag | Produkcija celičnega klona folikle stimulirajočega hormona FSH |
RS52106B (en) | 2008-02-08 | 2012-08-31 | Biogenerix Ag | LIQUID FSH PREPARATION |
TWI488640B (zh) | 2008-04-16 | 2015-06-21 | Ferring Int Ct Sa | 藥學製劑 |
CN101269215B (zh) * | 2008-05-15 | 2011-03-23 | 上海天伟生物制药有限公司 | 一种糖蛋白激素组合物 |
JP2009273427A (ja) | 2008-05-16 | 2009-11-26 | Jcr Pharmaceuticals Co Ltd | 組換え体ヒトfshの製造方法 |
CN102448979B (zh) | 2009-04-01 | 2015-03-04 | 拉蒂奥法姆有限责任公司 | 纯化重组促卵泡激素的方法 |
TWI532495B (zh) | 2009-10-05 | 2016-05-11 | 菲瑞茵國際中心股份有限公司 | 藥學製劑 |
EP2325194A1 (de) | 2009-11-24 | 2011-05-25 | Glycotope GmbH | Verfahren zur Reinigung von Glykoproteinen |
CN103619358B (zh) | 2011-03-31 | 2017-02-15 | 辉凌公司 | 药物制剂 |
CN103509121B (zh) | 2012-11-22 | 2015-01-28 | 苏州康宁杰瑞生物科技有限公司 | 一种fsh融合蛋白及其制备方法和用途 |
CN106687172B (zh) | 2014-09-11 | 2020-06-23 | 久光制药株式会社 | 微针装置 |
CN107106658B (zh) | 2014-10-27 | 2021-07-09 | 久光制药株式会社 | 含有基因重组型卵泡刺激激素的微针装置 |
CN110072542A (zh) * | 2016-10-11 | 2019-07-30 | 恩科格林医疗股份公司 | 在肿瘤的诊断和治疗中的fsh激素受体的配体 |
CN111349154A (zh) * | 2018-12-21 | 2020-06-30 | 江苏众红生物工程创药研究院有限公司 | 一种重组人促卵泡激素及其制备方法和药物应用 |
WO2021132957A1 (ko) * | 2019-12-26 | 2021-07-01 | 주식회사 엘지화학 | 여포 자극 호르몬의 정제 방법 |
CN116120449A (zh) * | 2021-07-09 | 2023-05-16 | 苏州晟济药业有限公司 | 抗体以及包含其的结合剂、免疫吸附材料及其应用 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3852422A (en) * | 1971-06-26 | 1974-12-03 | Serono Ist Farm | Long-active gonadotropins |
SU618113A1 (ru) * | 1976-11-19 | 1978-08-05 | Всесоюзный научно-исследовательский институт технологии кровезаменителей и гормональных препаратов | Способ получени фолликулостимулирующего гормона |
US4923805A (en) * | 1983-11-02 | 1990-05-08 | Integrated Genetics, Inc. | Fsh |
ATE65407T1 (de) * | 1984-04-03 | 1991-08-15 | Serono Lab | Verfahren zur herbeifuehrung der ovulation. |
US4845077A (en) * | 1984-04-03 | 1989-07-04 | Serono Laboratories, Inc. | Method of inducing ovulation |
GB8510177D0 (en) * | 1985-04-22 | 1985-05-30 | Public Health Laborotory Servi | Isolating pituitary glycoprotein hormones |
GB2174600B (en) * | 1985-05-10 | 1989-12-20 | Univ Melbourne | Induction of ovulation in mares |
IT1206302B (it) * | 1987-06-26 | 1989-04-14 | Serono Cesare Ist Ricerca | Ormone follicolo-stimolante urinario |
-
1987
- 1987-06-26 IT IT8748110A patent/IT1206302B/it active
-
1988
- 1988-06-23 ZA ZA884492A patent/ZA884492B/xx unknown
- 1988-06-23 IL IL86847A patent/IL86847A/xx not_active IP Right Cessation
- 1988-06-24 GR GR880100418A patent/GR1003186B/el not_active IP Right Cessation
- 1988-06-24 MX MX9203471A patent/MX9203471A/es unknown
- 1988-06-24 GE GEAP19881706A patent/GEP19971042B/en unknown
- 1988-06-24 UA UA4613604A patent/UA19101A/uk unknown
- 1988-06-24 JP JP63505461A patent/JP2523843B2/ja not_active Expired - Lifetime
- 1988-06-24 CA CA000570438A patent/CA1340649C/en not_active Expired - Lifetime
- 1988-06-24 RU SU4613604/14A patent/RU2059412C1/ru active
- 1988-06-24 EP EP88906018A patent/EP0322438B1/de not_active Expired - Lifetime
- 1988-06-24 AU AU19620/88A patent/AU615930B2/en not_active Expired
- 1988-06-24 ES ES8801994A patent/ES2009948A6/es not_active Expired
- 1988-06-24 WO PCT/IT1988/000048 patent/WO1988010270A1/en active IP Right Grant
- 1988-06-24 AT AT88906018T patent/ATE115148T1/de not_active IP Right Cessation
- 1988-06-24 AR AR88311231A patent/AR243241A1/es active
- 1988-06-24 DE DE3852383T patent/DE3852383T2/de not_active Expired - Lifetime
- 1988-06-24 RU SU4743338/13A patent/RU2105012C1/ru active
- 1988-06-24 US US07/337,766 patent/US5128453A/en not_active Expired - Lifetime
- 1988-06-24 KR KR1019890700354A patent/KR0156565B1/ko not_active IP Right Cessation
- 1988-06-25 CN CN88103966A patent/CN1031714C/zh not_active Expired - Lifetime
-
1989
- 1989-02-24 DK DK198900899A patent/DK173349B1/da not_active IP Right Cessation
- 1989-02-24 NO NO890805A patent/NO177498C/no not_active IP Right Cessation
- 1989-02-24 FI FI890893A patent/FI96608C/fi active IP Right Grant
-
1993
- 1993-08-25 GE GEAP19931489A patent/GEP19981274B/en unknown
- 1993-11-17 LV LVP-93-1241A patent/LV10628B/xx unknown
- 1993-11-22 LV LVP-93-1256A patent/LV10196B/lv unknown
- 1993-12-21 LT LTIP1654A patent/LT3999B/lt not_active IP Right Cessation
- 1993-12-21 LT LTIP1652A patent/LT4018B/lt not_active IP Right Cessation
-
1995
- 1995-03-30 US US08/413,936 patent/US5767067A/en not_active Expired - Lifetime
- 1995-07-20 CN CN95107562A patent/CN1069062C/zh not_active Expired - Lifetime
- 1995-09-07 HK HK143195A patent/HK143195A/xx not_active IP Right Cessation
- 1995-12-29 US US08/580,858 patent/US5840857A/en not_active Expired - Fee Related
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8310 | Action for declaration of annulment | ||
8312 | Partial invalidation | ||
8327 | Change in the person/name/address of the patent owner |
Owner name: INDUSTRIA FARMACEUTICA SERONO S.P.A., ROM/ROMA, IT |