DE3887052D1 - Menschliche, Insulin ähnliche Wachstumfaktoren mit reduzierter Bindung zu Serumträgerproteinen und ihre Herstellung in Hefe. - Google Patents

Menschliche, Insulin ähnliche Wachstumfaktoren mit reduzierter Bindung zu Serumträgerproteinen und ihre Herstellung in Hefe.

Info

Publication number
DE3887052D1
DE3887052D1 DE88202032T DE3887052T DE3887052D1 DE 3887052 D1 DE3887052 D1 DE 3887052D1 DE 88202032 T DE88202032 T DE 88202032T DE 3887052 T DE3887052 T DE 3887052T DE 3887052 D1 DE3887052 D1 DE 3887052D1
Authority
DE
Germany
Prior art keywords
promoting
higf
animals
carrier proteins
human
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE88202032T
Other languages
English (en)
Other versions
DE3887052T2 (de
Inventor
Joy D Applebaum
Marvin L Bayne
Margaret A Cascieri
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Application granted granted Critical
Publication of DE3887052D1 publication Critical patent/DE3887052D1/de
Publication of DE3887052T2 publication Critical patent/DE3887052T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/65—Insulin-like growth factors (Somatomedins), e.g. IGF-1, IGF-2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
DE3887052T 1987-09-21 1988-09-16 Menschliche, Insulin ähnliche Wachstumfaktoren mit reduzierter Bindung zu Serumträgerproteinen und ihre Herstellung in Hefe. Expired - Fee Related DE3887052T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/099,367 US4876242A (en) 1987-09-21 1987-09-21 Human insulin-like growth factor analoges with reduced binding to serum carrier proteins and their production in yeast

Publications (2)

Publication Number Publication Date
DE3887052D1 true DE3887052D1 (de) 1994-02-24
DE3887052T2 DE3887052T2 (de) 1994-07-21

Family

ID=22274659

Family Applications (1)

Application Number Title Priority Date Filing Date
DE3887052T Expired - Fee Related DE3887052T2 (de) 1987-09-21 1988-09-16 Menschliche, Insulin ähnliche Wachstumfaktoren mit reduzierter Bindung zu Serumträgerproteinen und ihre Herstellung in Hefe.

Country Status (16)

Country Link
US (1) US4876242A (de)
EP (1) EP0309050B1 (de)
JP (1) JPH01156998A (de)
KR (1) KR890005150A (de)
AT (1) ATE100139T1 (de)
AU (1) AU608364B2 (de)
DE (1) DE3887052T2 (de)
DK (1) DK521888A (de)
FI (1) FI884276A (de)
HU (1) HU205170B (de)
IL (1) IL87754A (de)
NO (1) NO174965C (de)
NZ (1) NZ226132A (de)
PT (1) PT88546B (de)
YU (2) YU46987B (de)
ZA (1) ZA886966B (de)

Families Citing this family (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1987001038A1 (en) * 1985-08-22 1987-02-26 Commonwealth Scientific And Industrial Research Or Peptide analogues of mammalian insulin-like growth factor-1
US5470828A (en) * 1987-12-24 1995-11-28 Gropep Pty. Ltd. Peptide analogs of insulin-like growth factor II
WO1989005822A1 (en) * 1987-12-24 1989-06-29 Gropep Pty. Ltd. Peptide analogues of insulin-like growth factor 1 (igf-1) or factor 2 (igf-2)
NZ236618A (en) * 1990-01-03 1997-06-24 Ciba Geigy Ag Treating and preventing osteoporosis using insulin-like growth factor i (igf i) in conjunction with a bone antiresorptive active compound
US5679771A (en) * 1990-02-13 1997-10-21 Gropep Pty. Ltd. Method for treating intestinal diseases
AU661242B2 (en) * 1991-10-07 1995-07-13 Brigham And Women's Hospital Method for enhancing gut absorption
EP0639981A4 (de) * 1992-05-08 1995-06-28 Univ Jefferson Analoge des igf-faktors(18.01.94).
EP0648264A4 (de) * 1992-06-03 1997-10-01 Univ Case Western Reserve Permanenter verband zur verabreichung von biologischen produkten.
WO1993025226A1 (en) * 1992-06-08 1993-12-23 Kabi Pharmacia Ab Use of growth factor igf-i and/or igf-ii
US5444045A (en) * 1992-09-17 1995-08-22 Gropep, Pty. Ltd. Method of administering IGF-1, IGF-2, and analogs thereof to birds
US5401830A (en) * 1992-10-05 1995-03-28 The State University Of New Jersey Insulin receptor-like protein
ES2241906T3 (es) * 1993-09-20 2005-11-01 Celtrix Pharmaceuticals, Inc. Tratamiento de trastornos inmunologicos y hematologicos con igfbp solo o asociado con igf.
AU3545795A (en) * 1994-09-08 1996-03-27 Chiron Corporation A method of improved production of insulin-like growth factor
US5741776A (en) * 1995-05-22 1998-04-21 Genentech, Inc. Method of administration of IGF-I
US5565428A (en) * 1995-05-22 1996-10-15 Genentech, Inc. Method of administration of IGF-I
US6420518B1 (en) 1997-04-04 2002-07-16 Genetech, Inc. Insulin-like growth factor agonist molecules
US6121416A (en) 1997-04-04 2000-09-19 Genentech, Inc. Insulin-like growth factor agonist molecules
US7700353B2 (en) 1998-07-22 2010-04-20 E-P Therapeutics, Inc. Compositions and methods for inducing apoptosis in tumor cells
US7118752B2 (en) 1998-07-22 2006-10-10 University Of Connecticut Compositions and methods for inhibiting the proliferation and invasiveness of malignant cells comprising E-domain peptides of IGF-I
US6358916B1 (en) 1998-07-22 2002-03-19 Thomas T. Chen Biological activity of IGF-I E domain peptide
US7173005B2 (en) 1998-09-02 2007-02-06 Antyra Inc. Insulin and IGF-1 receptor agonists and antagonists
US6875741B2 (en) 1998-09-02 2005-04-05 Renuka Pillutla Insulin and IGF-1 receptor agonists and antagonists
WO2000040613A1 (en) * 1999-01-06 2000-07-13 Genentech, Inc. Insulin-like growth factor (igf) i mutant variants
DE60005806T2 (de) 1999-04-08 2004-08-05 Genentech, Inc., South San Francisco Zusammensetzung auf basis gegensätzlich geladener polypeptide
US6703040B2 (en) * 2000-01-11 2004-03-09 Intralytix, Inc. Polymer blends as biodegradable matrices for preparing biocomposites
ATE529435T1 (de) * 2000-03-29 2011-11-15 Dgi Biotechnologies L L C Agonisten und antagonisten der rezeptoren des insulin und des igf-1
EP1282437B1 (de) * 2000-05-16 2008-03-19 Genentech, Inc. Behandlung von knorpelerkrankungen
US20060105946A9 (en) * 2000-08-29 2006-05-18 Ishii Douglas N Method for treating the central nervous system by administration of igf structural analogs
GB2369572A (en) * 2000-11-29 2002-06-05 Raft Trustees Ltd Wound treatment composition comprising insulin
DE60233359D1 (de) * 2001-02-09 2009-09-24 Genentech Inc Verfahren zur Identifizierung von indirekten IGF-1-Agonisten
AU2003273615B2 (en) * 2002-06-11 2010-07-29 Brigham And Women's Hospital Neuroprotective synergy of erythropoietin and insulin-like growth factor
ATE536186T1 (de) 2003-09-12 2011-12-15 Tercica Inc Verfahren zur behandlung von igf-1 (insulin-like growth factor 1)-mangel
US9011880B2 (en) * 2003-10-21 2015-04-21 Igf Oncology, Llc Compounds and methods for treating cancer
EP1680073B1 (de) * 2003-10-21 2013-01-02 IGF Oncology, LLC Verbindungen und verfahren zur behandlung von krebs
WO2005072292A2 (en) * 2004-01-24 2005-08-11 Hugh Mctavish Methods for enhancing radiation therapy
CA2582552A1 (en) 2004-10-21 2006-05-04 Igf Oncology, Llc Toxins and radionuclides coupled to igf-1 receptor ligands for treatment of cancer
US7833513B2 (en) 2004-12-03 2010-11-16 Rhode Island Hospital Treatment of Alzheimer's Disease
WO2009099763A1 (en) 2008-01-30 2009-08-13 Indiana University Research And Technology Corporation Ester-based peptide prodrugs
CA2744558A1 (en) 2008-12-19 2010-07-15 Indiana University Research And Technology Corporation Amide-based insulin prodrugs
WO2010080607A1 (en) * 2008-12-19 2010-07-15 Indiana University Research And Technology Corporation Yl-based insulin-like growth factors exhibiting high activity at the insulin receptor
EP2376520B1 (de) 2008-12-19 2014-02-12 Indiana University Research&Technology Corporation Insulin-analoga
EP2391630A2 (de) * 2009-01-31 2011-12-07 IGF Oncology, LLC Anti-krebs protein-platinum-konjugate
WO2010109053A1 (es) 2009-03-27 2010-09-30 Proyeto De Biomedicina Cima, S.L. Métodos y composiciones para el tratamiento de cirrosis y fibrosis hepática
WO2011057249A2 (en) 2009-11-09 2011-05-12 The Brigham And Women's Hospital, Inc. Treatment of heart disease
EP2582719B1 (de) 2010-06-16 2016-08-10 Indiana University Research and Technology Corporation Einkettige insulinagonisten mit hoher aktivität am insulinrezeptor
US8946147B2 (en) 2010-06-24 2015-02-03 Indiana University Research And Technology Corporation Amide-based insulin prodrugs
WO2013096386A1 (en) 2011-12-20 2013-06-27 Indiana University Research And Technology Corporation Ctp-based insulin analogs for treatment of diabetes
WO2014004512A1 (en) 2012-06-25 2014-01-03 Surmodics, Inc. Bioerodable poly(etheresteramides) and medical article uses
JP6387008B2 (ja) 2012-09-26 2018-09-05 インディアナ ユニバーシティー リサーチ アンド テクノロジー コーポレーションＩｎｄｉａｎａ Ｕｎｉｖｅｒｓｉｔｙ Ｒｅｓｅａｒｃｈ Ａｎｄ Ｔｅｃｈｎｏｌｏｇｙ Ｃｏｒｐｏｒａｔｉｏｎ インスリンアナローグダイマー
CN105324397B (zh) 2013-03-14 2020-01-14 印第安纳大学研究及科技有限公司 胰岛素-肠促胰岛素缀合物
EP3094339B1 (de) 2014-01-12 2019-12-11 IGF Oncology, LLC Fusionsproteine mit insulinähnlichem wachstumsfaktor-1 und epidermalem wachstumsfaktor sowie varianten davon
CN107001441A (zh) 2014-09-24 2017-08-01 印第安纳大学研究及科技有限公司 脂质化的基于酰胺的胰岛素前药
JP6657230B2 (ja) 2014-09-24 2020-03-04 インディアナ ユニヴァーシティ リサーチ アンド テクノロジー コーポレイション インクレチン−インスリンコンジュゲート
JP7114843B2 (ja) 2017-05-21 2022-08-09 アイジーエフ オンコロジー、 エルエルシー 骨髄異形成症候群の治療のためのインスリン様増殖因子－化学療法剤結合体

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1985000831A1 (en) * 1983-08-10 1985-02-28 Amgen Microbial expression of insulin-like growth factor
GB8507833D0 (en) * 1985-03-26 1985-05-01 Biogen Nv Production of human somatomedin c
WO1987001038A1 (en) * 1985-08-22 1987-02-26 Commonwealth Scientific And Industrial Research Or Peptide analogues of mammalian insulin-like growth factor-1
US4963665A (en) * 1986-01-07 1990-10-16 Washington University Human preproinsulin-like growth factor I
AU613876B2 (en) * 1986-10-01 1991-08-15 Merck & Co., Inc. Synthetic genes encoding proteins from plasmid containing eucaryotic secretory signal peptides and process for secreting encoded proteins
CA1314507C (en) * 1987-04-23 1993-03-16 Edith Yee-Tak Wong Secretion of insulin-like growth factor-i in e. coli

Also Published As

Publication number Publication date
IL87754A0 (en) 1989-02-28
NO884183D0 (no) 1988-09-20
YU46987B (sh) 1994-09-09
IL87754A (en) 1993-08-18
EP0309050B1 (de) 1994-01-12
PT88546B (pt) 1992-11-30
DE3887052T2 (de) 1994-07-21
FI884276A (fi) 1989-03-22
HU205170B (en) 1992-03-30
FI884276A0 (fi) 1988-09-16
AU2245588A (en) 1989-06-01
NO884183L (no) 1989-03-22
EP0309050A1 (de) 1989-03-29
DK521888D0 (da) 1988-09-20
NO174965B (no) 1994-05-02
NO174965C (no) 1994-08-10
US4876242A (en) 1989-10-24
ZA886966B (en) 1989-05-30
NZ226132A (en) 1992-02-25
KR890005150A (ko) 1989-05-13
HUT49375A (en) 1989-09-28
JPH01156998A (ja) 1989-06-20
YU216789A (en) 1991-04-30
YU177388A (en) 1990-04-30
AU608364B2 (en) 1991-03-28
PT88546A (pt) 1988-10-01
DK521888A (da) 1989-05-03
ATE100139T1 (de) 1994-01-15

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee