DE3887052D1 - Menschliche, Insulin ähnliche Wachstumfaktoren mit reduzierter Bindung zu Serumträgerproteinen und ihre Herstellung in Hefe. - Google Patents

Menschliche, Insulin ähnliche Wachstumfaktoren mit reduzierter Bindung zu Serumträgerproteinen und ihre Herstellung in Hefe.

Info

Publication number
DE3887052D1
DE3887052D1 DE88202032T DE3887052T DE3887052D1 DE 3887052 D1 DE3887052 D1 DE 3887052D1 DE 88202032 T DE88202032 T DE 88202032T DE 3887052 T DE3887052 T DE 3887052T DE 3887052 D1 DE3887052 D1 DE 3887052D1
Authority
DE
Germany
Prior art keywords
promoting
higf
animals
carrier proteins
human
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE88202032T
Other languages
English (en)
Other versions
DE3887052T2 (de
Inventor
Joy D Applebaum
Marvin L Bayne
Margaret A Cascieri
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Application granted granted Critical
Publication of DE3887052D1 publication Critical patent/DE3887052D1/de
Publication of DE3887052T2 publication Critical patent/DE3887052T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/65—Insulin-like growth factors (Somatomedins), e.g. IGF-1, IGF-2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Reproductive Health (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Fodder In General (AREA)
  • Compounds Of Unknown Constitution (AREA)
DE3887052T 1987-09-21 1988-09-16 Menschliche, Insulin ähnliche Wachstumfaktoren mit reduzierter Bindung zu Serumträgerproteinen und ihre Herstellung in Hefe. Expired - Fee Related DE3887052T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/099,367 US4876242A (en) 1987-09-21 1987-09-21 Human insulin-like growth factor analoges with reduced binding to serum carrier proteins and their production in yeast

Publications (2)

Publication Number Publication Date
DE3887052D1 true DE3887052D1 (de) 1994-02-24
DE3887052T2 DE3887052T2 (de) 1994-07-21

Family

ID=22274659

Family Applications (1)

Application Number Title Priority Date Filing Date
DE3887052T Expired - Fee Related DE3887052T2 (de) 1987-09-21 1988-09-16 Menschliche, Insulin ähnliche Wachstumfaktoren mit reduzierter Bindung zu Serumträgerproteinen und ihre Herstellung in Hefe.

Country Status (16)

Country Link
US (1) US4876242A (de)
EP (1) EP0309050B1 (de)
JP (1) JPH01156998A (de)
KR (1) KR890005150A (de)
AT (1) ATE100139T1 (de)
AU (1) AU608364B2 (de)
DE (1) DE3887052T2 (de)
DK (1) DK521888A (de)
FI (1) FI884276A (de)
HU (1) HU205170B (de)
IL (1) IL87754A (de)
NO (1) NO174965C (de)
NZ (1) NZ226132A (de)
PT (1) PT88546B (de)
YU (2) YU46987B (de)
ZA (1) ZA886966B (de)

Families Citing this family (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU598205B2 (en) * 1985-08-22 1990-06-21 Gropep Pty Ltd Peptide analogues of mammalian insulin-like growth factor-1
JP2507106B2 (ja) * 1987-12-24 1996-06-12 グロペップ プロプライエタリー リミテッド インスリン様成長因子１（ｉｇｆ―１）または因子２（ｉｇｆ―２）の類縁ペプチド
US5470828A (en) * 1987-12-24 1995-11-28 Gropep Pty. Ltd. Peptide analogs of insulin-like growth factor II
NZ236618A (en) * 1990-01-03 1997-06-24 Ciba Geigy Ag Treating and preventing osteoporosis using insulin-like growth factor i (igf i) in conjunction with a bone antiresorptive active compound
US5679771A (en) * 1990-02-13 1997-10-21 Gropep Pty. Ltd. Method for treating intestinal diseases
ATE216253T1 (de) * 1991-10-07 2002-05-15 Brigham & Womens Hospital Verfahren zur erhöhung der darmabsorption
JPH07508025A (ja) * 1992-05-08 1995-09-07 トーマス・ジェファーソン・ユニバーシティ インスリン様増殖因子（ｉｇｆ−１）類似体
EP0648264A4 (de) * 1992-06-03 1997-10-01 Univ Case Western Reserve Permanenter verband zur verabreichung von biologischen produkten.
JPH06510065A (ja) * 1992-06-08 1994-11-10 カイロン　コーポレーション 成長因子ｉｇｆ−ｉおよび／またはｉｇｆ−ｉｉの用法
US5444045A (en) * 1992-09-17 1995-08-22 Gropep, Pty. Ltd. Method of administering IGF-1, IGF-2, and analogs thereof to birds
US5401830A (en) * 1992-10-05 1995-03-28 The State University Of New Jersey Insulin receptor-like protein
ATE297214T1 (de) * 1993-09-20 2005-06-15 Celtrix Pharma Behandlung von immunologischen und hematologischen störungen mit igfbp allein oder als komplex mit igf
AU3545795A (en) * 1994-09-08 1996-03-27 Chiron Corporation A method of improved production of insulin-like growth factor
US5741776A (en) * 1995-05-22 1998-04-21 Genentech, Inc. Method of administration of IGF-I
US5565428A (en) * 1995-05-22 1996-10-15 Genentech, Inc. Method of administration of IGF-I
US6121416A (en) 1997-04-04 2000-09-19 Genentech, Inc. Insulin-like growth factor agonist molecules
US6420518B1 (en) 1997-04-04 2002-07-16 Genetech, Inc. Insulin-like growth factor agonist molecules
US7700353B2 (en) 1998-07-22 2010-04-20 E-P Therapeutics, Inc. Compositions and methods for inducing apoptosis in tumor cells
US6358916B1 (en) * 1998-07-22 2002-03-19 Thomas T. Chen Biological activity of IGF-I E domain peptide
US7118752B2 (en) 1998-07-22 2006-10-10 University Of Connecticut Compositions and methods for inhibiting the proliferation and invasiveness of malignant cells comprising E-domain peptides of IGF-I
US6875741B2 (en) 1998-09-02 2005-04-05 Renuka Pillutla Insulin and IGF-1 receptor agonists and antagonists
US7173005B2 (en) 1998-09-02 2007-02-06 Antyra Inc. Insulin and IGF-1 receptor agonists and antagonists
EP1141014B1 (de) * 1999-01-06 2004-12-08 Genentech, Inc. Mutierte variante des insulin-ähnlichen wachstumsfaktor-i (igf-i)
DE60005806T2 (de) * 1999-04-08 2004-08-05 Genentech, Inc., South San Francisco Zusammensetzung auf basis gegensätzlich geladener polypeptide
US6703040B2 (en) * 2000-01-11 2004-03-09 Intralytix, Inc. Polymer blends as biodegradable matrices for preparing biocomposites
JP2004512010A (ja) * 2000-03-29 2004-04-22 ディージーアイ・バイオテクノロジーズ・エル・エル・シー インスリン及びｉｇｆ−１受容体のアゴニスト及びアンタゴニスト
EP1282437B1 (de) 2000-05-16 2008-03-19 Genentech, Inc. Behandlung von knorpelerkrankungen
ES2346185T3 (es) * 2000-08-29 2010-10-13 Aurogen Incorporated Metodo para tratar el sistema nervioso central mediante la administracion de analogos estructurales de igf.
GB2369572A (en) 2000-11-29 2002-06-05 Raft Trustees Ltd Wound treatment composition comprising insulin
AU2002255508B2 (en) * 2001-02-09 2008-04-03 Genentech, Inc. Crystallization of IGF-1
EP1535065A4 (de) * 2002-06-11 2007-07-11 Burnham Inst Neuroprotektive synergie von erythropoetin und insulinähnlichem wachstumsfaktor
NZ545940A (en) 2003-09-12 2009-12-24 Tercica Inc Methods for treatment of insulin-like growth factor-1 (IGF-1) deficiency
EP1680073B1 (de) * 2003-10-21 2013-01-02 IGF Oncology, LLC Verbindungen und verfahren zur behandlung von krebs
US9011880B2 (en) * 2003-10-21 2015-04-21 Igf Oncology, Llc Compounds and methods for treating cancer
WO2005072292A2 (en) * 2004-01-24 2005-08-11 Hugh Mctavish Methods for enhancing radiation therapy
EP1812082B1 (de) * 2004-10-21 2013-08-14 IGF Oncology, LLC An IGF-1-Rezeptorliganden gekoppelte Toxine und Radionuklide zur Krebsbehandlung
US7833513B2 (en) 2004-12-03 2010-11-16 Rhode Island Hospital Treatment of Alzheimer's Disease
CN101983066B (zh) 2008-01-30 2016-06-29 印第安那大学科技研究公司 基于酯的胰岛素前药
CN102307584A (zh) * 2008-12-19 2012-01-04 印第安纳大学研究及科技有限公司 表现出对胰岛素受体的高活性的基于yl的胰岛素-样生长因子
AU2009335715B2 (en) 2008-12-19 2016-09-15 Indiana University Research And Technology Corporation Amide-based insulin prodrugs
US8481485B2 (en) 2008-12-19 2013-07-09 Indiana University Research And Technology Corporation Insulin analogs
EP2391630A2 (de) * 2009-01-31 2011-12-07 IGF Oncology, LLC Anti-krebs protein-platinum-konjugate
CN102448501A (zh) 2009-03-27 2012-05-09 西马生物医学计划公司 治疗肝硬化和肝纤维化的方法和组合物
US20120321595A1 (en) 2009-11-09 2012-12-20 The Brigham And Women's Hospital, Inc. Treatment of heart disease
CN103068842B (zh) 2010-06-16 2016-10-19 印第安纳大学研究及科技有限公司 对胰岛素受体具有高活性的单链胰岛素激动剂
EP2585102B1 (de) 2010-06-24 2015-05-06 Indiana University Research and Technology Corporation Auf amid basierende insulin-prodrugs
CN104114183A (zh) 2011-12-20 2014-10-22 印第安纳大学研究及科技有限公司 用于治疗糖尿病的基于ctp的胰岛素类似物
US9375519B2 (en) 2012-06-25 2016-06-28 Surmodics, Inc. Bioerodable poly(etheresteramides) and medical article uses
JP6387008B2 (ja) 2012-09-26 2018-09-05 インディアナ ユニバーシティー リサーチ アンド テクノロジー コーポレーションＩｎｄｉａｎａ Ｕｎｉｖｅｒｓｉｔｙ Ｒｅｓｅａｒｃｈ Ａｎｄ Ｔｅｃｈｎｏｌｏｇｙ Ｃｏｒｐｏｒａｔｉｏｎ インスリンアナローグダイマー
WO2014158900A1 (en) 2013-03-14 2014-10-02 Indiana University Research And Technology Corporation Insulin-incretin conjugates
US9675671B2 (en) 2014-01-12 2017-06-13 Igf Oncology, Llc Fusion proteins containing insulin-like growth factor-1 and epidermal growth factor and variants thereof and uses thereof
CN108271356A (zh) 2014-09-24 2018-07-10 印第安纳大学研究及科技有限公司 肠降血糖素-胰岛素缀合物
JP6701208B2 (ja) 2014-09-24 2020-05-27 インディアナ ユニヴァーシティ リサーチ アンド テクノロジー コーポレイション 脂質化アミド系インスリンプロドラッグ
CA3059593A1 (en) 2017-05-21 2018-11-29 Igf Oncology, Llc An insulin-like growth factor-chemotherapeputic conjugate for treating myelodysplastic syndrome

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1985000831A1 (en) * 1983-08-10 1985-02-28 Amgen Microbial expression of insulin-like growth factor
GB8507833D0 (en) * 1985-03-26 1985-05-01 Biogen Nv Production of human somatomedin c
AU598205B2 (en) * 1985-08-22 1990-06-21 Gropep Pty Ltd Peptide analogues of mammalian insulin-like growth factor-1
US4963665A (en) * 1986-01-07 1990-10-16 Washington University Human preproinsulin-like growth factor I
AU613876B2 (en) * 1986-10-01 1991-08-15 Merck & Co., Inc. Synthetic genes encoding proteins from plasmid containing eucaryotic secretory signal peptides and process for secreting encoded proteins
ATE109828T1 (de) * 1987-04-23 1994-08-15 Monsanto Co Sekretion eines dem insulin ähnlichen wachstumsfaktors in e. coli.

Also Published As

Publication number Publication date
HUT49375A (en) 1989-09-28
AU2245588A (en) 1989-06-01
YU46987B (sh) 1994-09-09
YU216789A (en) 1991-04-30
JPH01156998A (ja) 1989-06-20
NO884183L (no) 1989-03-22
NO884183D0 (no) 1988-09-20
AU608364B2 (en) 1991-03-28
NO174965C (no) 1994-08-10
DE3887052T2 (de) 1994-07-21
PT88546B (pt) 1992-11-30
YU177388A (en) 1990-04-30
EP0309050B1 (de) 1994-01-12
US4876242A (en) 1989-10-24
DK521888A (da) 1989-05-03
NZ226132A (en) 1992-02-25
FI884276A0 (fi) 1988-09-16
DK521888D0 (da) 1988-09-20
IL87754A (en) 1993-08-18
HU205170B (en) 1992-03-30
NO174965B (no) 1994-05-02
EP0309050A1 (de) 1989-03-29
FI884276A (fi) 1989-03-22
IL87754A0 (en) 1989-02-28
PT88546A (pt) 1988-10-01
KR890005150A (ko) 1989-05-13
ZA886966B (en) 1989-05-30
ATE100139T1 (de) 1994-01-15

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee