DE4242533A1 - Glucose sensor with gas flushing for detections in-vivo - Google Patents

Glucose sensor with gas flushing for detections in-vivo

Info

Publication number
DE4242533A1
DE4242533A1 DE19924242533 DE4242533A DE4242533A1 DE 4242533 A1 DE4242533 A1 DE 4242533A1 DE 19924242533 DE19924242533 DE 19924242533 DE 4242533 A DE4242533 A DE 4242533A DE 4242533 A1 DE4242533 A1 DE 4242533A1
Authority
DE
Germany
Prior art keywords
gas
valve
sensor
glucose sensor
measurement
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE19924242533
Other languages
German (de)
Inventor
Erwin Dr Schaefer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to DE19924242533 priority Critical patent/DE4242533A1/en
Publication of DE4242533A1 publication Critical patent/DE4242533A1/en
Withdrawn legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28—Electrolytic cell components
    • G01N27/30—Electrodes, e.g. test electrodes; Half-cells
    • G01N27/38—Cleaning of electrodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring glucose, e.g. by tissue impedance measurement

Abstract

In the measurement-free interval, a gas-form medium, pref. carbon dioxide, flows from a pressure container (4) with redn valve (5) through the sensor and deviates over a fine-pored membrane (6), which on the rear side is coated with cross-moistened glucose oxidase (7). On a control signal, a valve (8) interrupts the gas flow. The gas in the sensor is released by the incoming filtrate. After the measurement has been effected, the valve is further opened and the sensor dried. Dependent on the measurement signal from the pressurised storage container (9), a specific amt of medication predetermined by the opening time of the valve (10) can be applied.

Description

Es ist bekannt, daß Glukosesensoren auf dem Prinzip der polarographischen Elektrode basieren, die mit einer glukosesensitiven Membran umgeben ist. Andere Möglichkeiten nützen die katalytischen Eigenschaften des Platins aus und operieren als sogenannte Energiezellen, oder sie sind als elektrokatalytische Sensoren ausgelegt. Die bisherigen Systeme leiden jedoch unter der Abwehrreaktion des Organismus und werden durch Überschichten mit Fibrin, Blutplättchen usw. ausgeschaltet, eine dauerhafte Feedback-Regulation ist nicht möglich. Zier, H. et al.: Biomedizinische Technik 35 (1990), S. 2-4, Guyton, JR. et al. Horm Metab Res (suppl) 8 (1979), S. 24-26.It is known that glucose sensors operate on the principle of polarographic electrode based, with a glucose sensitive Membrane is surrounded. Other options are used catalytic properties of platinum and operate as so-called energy cells, or they are called electrocatalytic Sensors. However, the previous systems suffer the immune response of the organism and are covered by overlays with fibrin, platelets, etc. turned off, a permanent one Feedback regulation is not possible. Zier, H. et al .: Biomedical Engineering 35 (1990), pp. 2-4, Guyton, JR. et al. Horm Metab Res (suppl) 8 (1979), pp. 24-26.

Der im Patentanspruch 1 angegebenen Erfindung liegt das Problem zugrunde, die Unbrauchbarmachung des Sensors durch Abwehrreaktionen zu verhindern.The invention specified in claim 1 is the problem based on the rendering of the sensor unusable by defense reactions to prevent.

Dieses Problem wird durch die im Patentanspruch 1 aufgeführten Merkmale gelöst.This problem is caused by those listed in claim 1 Features resolved.

Die mit der Erfindung erzielten Vorteile bestehen insbesondere darin, daß durch die verlängerte Lebensdauer des Sensors eine dauerhafte Feedback-Regulation möglich wird.The advantages achieved with the invention are in particular the fact that the extended life of the sensor permanent feedback regulation becomes possible.

Eine vorteilhafte Ausgestaltung der Erfindung ist im Patentanspruch 2 angegeben. Die Weiterbildung nach Patentanspruch 2 ermöglicht eine konstanten Gewebe/Blutspiegel der Glukose durch hinzudosieren von Arzneimitteln.An advantageous embodiment of the invention is in Claim 2 specified. The further training according to claim 2 enables a constant tissue / blood level of the Glucose by adding drugs.

Ein Ausführungsbeispiel der Erfindung ist in der Zeichnung dargestellt und wird im folgenden näher beschrieben.An embodiment of the invention is in the drawing shown and is described in more detail below.

Fig. 1 zeigt den Sensor, den Flüssiggasbehälter, das Arzneimittelreservoir und die Ventile. Fig. 1 shows the sensor, the liquid gas container, the drug reservoir and the valves.

In der polarographischen Elektrode ist die Pt-Anode 1 mit einer gasdurchlässigen/flüssigkeitsundurchlässigen Manschette 3 gegen die Ag-Kathode 2 isoliert. In den meßfreien Intervallen strömt ein gasförmiges Medium, vorzugsweise Kohlendioxid, aber auch andere körperverträgliche und bei Körpertemperatur verflüssigbare Gase sind möglich, aus dem Druckbehälter 4 mit Reduzierventil 5 durch den Sensor und entweicht über die feinporige Membran 6, die rückseitig mit quervernetzter Glukoseoxidase 7 beschichtet ist. Auf ein Steuersignal hin unterbricht ein Ventil 8 den Gaszufluß. Das Gas im Sensor wird durch das einströmende Filtrat gelöst. Nachdem die Messung abgelaufen ist, wird das Ventil wieder geöffnet und der Sensor trockengelegt. In Abhängigkeit des Meßsignals kann aus dem unter Druck stehendem Vorratsbehälter 9 eine bestimmte, durch die Öffnungszeit des Ventils 10 vorgegebene Menge eines Arzneimittels appliziert werden.In the polarographic electrode, the Pt anode 1 is insulated from the Ag cathode 2 with a gas-permeable / liquid-impermeable sleeve 3 . In the measurement-free intervals, a gaseous medium, preferably carbon dioxide, but also other body-compatible and liquefiable gases at body temperature are possible, from the pressure vessel 4 with reducing valve 5 through the sensor and escapes through the fine-pored membrane 6 , which is coated on the back with cross-linked glucose oxidase 7 . In response to a control signal, a valve 8 interrupts the gas flow. The gas in the sensor is released by the inflowing filtrate. After the measurement has been completed, the valve is opened again and the sensor is drained. Depending on the measurement signal, a certain amount of a drug, which is predetermined by the opening time of the valve 10, can be applied from the pressurized reservoir 9 .

Claims (4)

1. Glukosesensor mit Gasspülung der polarographischen Elektrode und der sensitiven Membran für Detektionen in vivo, wobei die polarographische Elektrode mit einer gasdurchlässigen Isolierung versehen ist, durch die die Meßkammer und die sensitive Membran periodisch aus einem externen Flüssiggasbehälter mit einem gasförmigen Medium, vorzugsweise Kohlendioxid, gespült wird, um vor Inaktivierung geschützt zu werden.1. Glucose sensor with gas purging of the polarographic electrode and the sensitive membrane for in vivo detection, the polarographic electrode with gas permeable insulation is provided, through which the measuring chamber and the sensitive membrane periodically from an external liquid gas container with a gaseous medium, preferably carbon dioxide, is flushed to before Inactivation to be protected. 2. Glukosesensor mit Gasspülung nach Anspruch 1, bei dem in Abhängigkeit des Meßsignals aus einem weiteren externen Flüssigkeitsspeicher, der von dem ersten durch eine elastische Membran getrennt ist, ein Hinzudosieren von Arzneistoffen mittels eines Ventils erfolgt.2. Glucose sensor with gas flushing according to claim 1, in which Dependency of the measurement signal from another external Liquid storage from the first through an elastic membrane is separated, a metering of drugs using a Valve takes place. 3. Gasspülung nach Anspruch 1, die das Freihalten von in den Körper gebrachten Verweilkathetern oder Sonden ermöglicht.3. Gas purging according to claim 1, which is kept free in the body brought indwelling catheters or probes. 4. Gasspülung nach Anspruch 1, die mit mehreren Flüssigkeitsspeichern kombiniert eine dauernde Applikation von Arzneimitteln mittels von Verweilkathetern gewährleistet.4. Gas purging according to claim 1, which with several Liquid storage combines a continuous application of Medicines guaranteed by indwelling catheters.
DE19924242533 1992-12-16 1992-12-16 Glucose sensor with gas flushing for detections in-vivo Withdrawn DE4242533A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DE19924242533 DE4242533A1 (en) 1992-12-16 1992-12-16 Glucose sensor with gas flushing for detections in-vivo

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19924242533 DE4242533A1 (en) 1992-12-16 1992-12-16 Glucose sensor with gas flushing for detections in-vivo

Publications (1)

Publication Number Publication Date
DE4242533A1 true DE4242533A1 (en) 1994-06-23

Family

ID=6475482

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19924242533 Withdrawn DE4242533A1 (en) 1992-12-16 1992-12-16 Glucose sensor with gas flushing for detections in-vivo

Country Status (1)

Country Link
DE (1) DE4242533A1 (en)

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3120773A1 (en) * 1981-05-25 1982-12-09 Franz-Josef Prof. Dr. 3550 Marburg Haberich Method of cleaning a membrane-type selective matrix in an ion-selective measuring electrode and system for carrying out said method
EP0098592A2 (en) * 1982-07-06 1984-01-18 Fujisawa Pharmaceutical Co., Ltd. Portable artificial pancreas
DD212984A1 (en) * 1982-12-31 1984-08-29 Akad Wissenschaften Ddr METHOD AND DEVICE FOR THE AUTOMATIC ANALYSIS OF BIOLOGICAL MEDIA
US4703756A (en) * 1986-05-06 1987-11-03 The Regents Of The University Of California Complete glucose monitoring system with an implantable, telemetered sensor module
EP0276977A2 (en) * 1987-01-30 1988-08-03 Minnesota Mining And Manufacturing Company Intravascular blood parameter measurement system
DE3718717A1 (en) * 1987-06-04 1988-12-22 Wolf Gmbh Richard DEVICE FOR INSUFFLING GAS INTO A BODY CAVE
EP0354719A1 (en) * 1988-08-08 1990-02-14 Minnesota Mining And Manufacturing Company Blood parameter measurement system
US4917776A (en) * 1989-02-09 1990-04-17 Larry Taylor Flow through voltammetric analyzer and method using deoxygenator
US5109850A (en) * 1990-02-09 1992-05-05 Massachusetts Institute Of Technology Automatic blood monitoring for medication delivery method and apparatus

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3120773A1 (en) * 1981-05-25 1982-12-09 Franz-Josef Prof. Dr. 3550 Marburg Haberich Method of cleaning a membrane-type selective matrix in an ion-selective measuring electrode and system for carrying out said method
EP0098592A2 (en) * 1982-07-06 1984-01-18 Fujisawa Pharmaceutical Co., Ltd. Portable artificial pancreas
DD212984A1 (en) * 1982-12-31 1984-08-29 Akad Wissenschaften Ddr METHOD AND DEVICE FOR THE AUTOMATIC ANALYSIS OF BIOLOGICAL MEDIA
US4703756A (en) * 1986-05-06 1987-11-03 The Regents Of The University Of California Complete glucose monitoring system with an implantable, telemetered sensor module
EP0276977A2 (en) * 1987-01-30 1988-08-03 Minnesota Mining And Manufacturing Company Intravascular blood parameter measurement system
DE3718717A1 (en) * 1987-06-04 1988-12-22 Wolf Gmbh Richard DEVICE FOR INSUFFLING GAS INTO A BODY CAVE
EP0354719A1 (en) * 1988-08-08 1990-02-14 Minnesota Mining And Manufacturing Company Blood parameter measurement system
US4917776A (en) * 1989-02-09 1990-04-17 Larry Taylor Flow through voltammetric analyzer and method using deoxygenator
US5109850A (en) * 1990-02-09 1992-05-05 Massachusetts Institute Of Technology Automatic blood monitoring for medication delivery method and apparatus

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