DE50015938D1 - Polypeptidvarianten mit erhoehter heparin-bindungsfaehigkeit - Google Patents
Polypeptidvarianten mit erhoehter heparin-bindungsfaehigkeitInfo
- Publication number
- DE50015938D1 DE50015938D1 DE50015938T DE50015938T DE50015938D1 DE 50015938 D1 DE50015938 D1 DE 50015938D1 DE 50015938 T DE50015938 T DE 50015938T DE 50015938 T DE50015938 T DE 50015938T DE 50015938 D1 DE50015938 D1 DE 50015938D1
- Authority
- DE
- Germany
- Prior art keywords
- sub
- polypeptide variants
- increased heparin
- binding capacity
- heparin binding
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/51—Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE50015938T DE50015938D1 (de) | 1999-02-13 | 2000-01-27 | Polypeptidvarianten mit erhoehter heparin-bindungsfaehigkeit |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19906096A DE19906096A1 (de) | 1999-02-13 | 1999-02-13 | Protein mit einem Heparin-bindenden Epitop |
DE50015938T DE50015938D1 (de) | 1999-02-13 | 2000-01-27 | Polypeptidvarianten mit erhoehter heparin-bindungsfaehigkeit |
PCT/EP2000/000637 WO2000047736A1 (de) | 1999-02-13 | 2000-01-27 | Polypeptidvarianten mit erhöhter heparin-bindungsfähigkeit |
Publications (1)
Publication Number | Publication Date |
---|---|
DE50015938D1 true DE50015938D1 (de) | 2010-07-22 |
Family
ID=7897433
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE19906096A Ceased DE19906096A1 (de) | 1999-02-13 | 1999-02-13 | Protein mit einem Heparin-bindenden Epitop |
DE50015938T Expired - Lifetime DE50015938D1 (de) | 1999-02-13 | 2000-01-27 | Polypeptidvarianten mit erhoehter heparin-bindungsfaehigkeit |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE19906096A Ceased DE19906096A1 (de) | 1999-02-13 | 1999-02-13 | Protein mit einem Heparin-bindenden Epitop |
Country Status (11)
Country | Link |
---|---|
US (1) | US7253254B1 (de) |
EP (1) | EP1151095B1 (de) |
JP (3) | JP4155711B2 (de) |
CN (1) | CN1169959C (de) |
AT (1) | ATE470713T1 (de) |
AU (1) | AU762387B2 (de) |
BR (1) | BR0008785A (de) |
CA (1) | CA2362496C (de) |
DE (2) | DE19906096A1 (de) |
RU (1) | RU2227743C2 (de) |
WO (1) | WO2000047736A1 (de) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7482427B2 (en) | 2002-08-20 | 2009-01-27 | Biosurface Engineering Technologies, Inc. | Positive modulator of bone morphogenic protein-2 |
US8328876B2 (en) | 2003-12-31 | 2012-12-11 | Warsaw Orthopedic, Inc. | Bone matrix compositions and methods |
US7910552B2 (en) | 2005-05-27 | 2011-03-22 | Bbs-Bioactive Bone Substitutes Oy | Bone morphogenetic proteins containing a heparin binding site and osteogenic devices and pharmaceutical products containing thereof |
US9216212B2 (en) | 2005-08-05 | 2015-12-22 | University Of Massachusetts | Virus-like particles as vaccines for paramyxovirus |
US7951384B2 (en) * | 2005-08-05 | 2011-05-31 | University Of Massachusetts | Virus-like particles as vaccines for paramyxovirus |
WO2007053850A2 (en) | 2005-11-01 | 2007-05-10 | Osteotech, Inc. | Bone matrix compositions and methods |
JP2007332106A (ja) * | 2006-06-16 | 2007-12-27 | Okayama Univ | 骨形成用徐放性医薬組成物 |
WO2007150053A2 (en) | 2006-06-22 | 2007-12-27 | Biosurface Engineering Technologies, Inc. | Composition and method for delivery of bmp-2 amplifier/co-activator for enhancement of osteogenesis |
US20080206299A1 (en) * | 2007-02-27 | 2008-08-28 | Shimp Lawrence A | Method for Recovering Minerals From Bone and Use of Same |
US9554920B2 (en) | 2007-06-15 | 2017-01-31 | Warsaw Orthopedic, Inc. | Bone matrix compositions having nanoscale textured surfaces |
WO2008157492A2 (en) | 2007-06-15 | 2008-12-24 | Osteotech, Inc. | Osteoinductive demineralized cancellous bone |
CA2690457C (en) | 2007-06-15 | 2018-02-20 | Osteotech, Inc. | Bone matrix compositions and methods |
US9492278B2 (en) | 2007-07-10 | 2016-11-15 | Warsaw Orthopedic, Inc. | Delivery system |
JP2009045142A (ja) * | 2007-08-16 | 2009-03-05 | Okayama Univ | 生体内にて基材周囲に骨形成を誘導するための基材処理方法 |
WO2010039224A2 (en) | 2008-09-30 | 2010-04-08 | University Of Massachusetts Medical School | Respiratory syncytial virus (rsv) sequences for protein expression and vaccines |
JP5799409B2 (ja) * | 2008-12-19 | 2015-10-28 | 国立大学法人 新潟大学 | ヘパリン親和性エリスロポエチン |
WO2010093955A1 (en) | 2009-02-12 | 2010-08-19 | Osteotech,Inc. | Segmented delivery system |
GB201601136D0 (en) | 2016-01-21 | 2016-03-09 | Mörgelin Matthias And Abdillahi Suado M | Novel polypeptides and medical uses thereof |
CA3048735A1 (en) | 2016-12-30 | 2018-07-05 | Biogend Therapeutics Co., Ltd. | Recombinant polypeptides, compositions, and methods thereof |
Family Cites Families (78)
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US4455256A (en) | 1981-05-05 | 1984-06-19 | The Regents Of The University Of California | Bone morphogenetic protein |
US4804744A (en) | 1984-01-04 | 1989-02-14 | International Genetic Engineering, Inc. | Osteogenic factors |
NZ210699A (en) | 1984-01-04 | 1989-06-28 | Int Genetic Eng | Isolation of an osteogenic protein of the p3 immunologically related family |
US4627982A (en) | 1984-07-16 | 1986-12-09 | Collagen Corporation | Partially purified bone-inducing factor |
ZA874681B (en) | 1986-07-01 | 1988-04-27 | Genetics Inst | Novel osteoinductive factors |
IL83003A (en) | 1986-07-01 | 1995-07-31 | Genetics Inst | Factors that soak bone formation |
US5106748A (en) | 1986-07-01 | 1992-04-21 | Genetics Institute, Inc. | Dna sequences encoding 5 proteins |
US5187076A (en) | 1986-07-01 | 1993-02-16 | Genetics Institute, Inc. | DNA sequences encoding BMP-6 proteins |
US5013649A (en) | 1986-07-01 | 1991-05-07 | Genetics Institute, Inc. | DNA sequences encoding osteoinductive products |
US5631142A (en) | 1986-07-01 | 1997-05-20 | Genetics Institute, Inc. | Compositions comprising bone morphogenetic protein-2 (BMP-2) |
US4877864A (en) | 1987-03-26 | 1989-10-31 | Genetics Institute, Inc. | Osteoinductive factors |
US6150328A (en) | 1986-07-01 | 2000-11-21 | Genetics Institute, Inc. | BMP products |
US5459047A (en) | 1986-07-01 | 1995-10-17 | Genetics Institute, Inc. | BMP-6 proteins |
US5366875A (en) | 1986-07-01 | 1994-11-22 | Genetics Institute, Inc. | Methods for producing BMP-7 proteins |
DE68925773T2 (de) | 1988-04-08 | 1996-10-17 | Stryker Corp | Osteogene vorrichtungen |
US5250302A (en) | 1988-04-08 | 1993-10-05 | Stryker Corporation | Osteogenic devices |
US5344654A (en) | 1988-04-08 | 1994-09-06 | Stryker Corporation | Prosthetic devices having enhanced osteogenic properties |
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US4975526A (en) | 1989-02-23 | 1990-12-04 | Creative Biomolecules, Inc. | Bone collagen matrix for zenogenic implants |
US5324819A (en) | 1988-04-08 | 1994-06-28 | Stryker Corporation | Osteogenic proteins |
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US4967737A (en) | 1988-08-03 | 1990-11-06 | Osteg Dyne Inc. | Method and device for treating bone disorders characterized by low bone mass |
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US5510418A (en) | 1988-11-21 | 1996-04-23 | Collagen Corporation | Glycosaminoglycan-synthetic polymer conjugates |
US4928959A (en) | 1988-12-16 | 1990-05-29 | Osteo-Dyne, Inc. | Method and device for providing active exercise treatment for a patient suffering from a bone disorder |
EP0384731B1 (de) | 1989-02-23 | 1996-12-18 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Osteogenische Wachstumfaktoren, die aus sich regenerierendem Knochenmark identifiziert werden |
WO1990010694A1 (en) * | 1989-03-06 | 1990-09-20 | Suntory Limited | New superoxide dismutase |
CA2030518C (en) | 1989-03-28 | 2000-03-21 | Elizabeth A. Wang | Osteoinductive compositions |
US5061786A (en) | 1989-05-25 | 1991-10-29 | Genentech, Inc. | Biologically active polypeptides based on transforming growth factor-β |
CA2020729A1 (en) | 1989-07-19 | 1991-01-20 | Michael C. Kiefer | Bone morphogenetic protein |
US5194596A (en) * | 1989-07-27 | 1993-03-16 | California Biotechnology Inc. | Production of vascular endothelial cell growth factor |
EP0416578B1 (de) | 1989-09-06 | 1996-07-31 | Takeda Chemical Industries, Ltd. | Protein, DNA und ihre Verwendung |
US5350836A (en) * | 1989-10-12 | 1994-09-27 | Ohio University | Growth hormone antagonists |
ATE167486T1 (de) | 1989-10-17 | 1998-07-15 | Stryker Corp | Osteogene vorrichtungen |
GB8927546D0 (en) | 1989-12-06 | 1990-02-07 | Ciba Geigy | Process for the production of biologically active tgf-beta |
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RU2208638C2 (ru) | 1992-02-12 | 2003-07-20 | Биофарм Гезельшафт Цур Биотехнологишен Энтвиклунг фон Фармака мбХ | Днк (варианты), способ получения белка, белок, фармацевтическая композиция |
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US5800811A (en) * | 1995-06-06 | 1998-09-01 | Hall; Frederick L. | Artificial skin prepared from coclagen matrix containing transforming growth factor-β having a collagen binding site |
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US5877153A (en) * | 1996-06-11 | 1999-03-02 | Commonwealth Biotechnologies Inc. | Heparin-binding peptides |
DE69738331T2 (de) | 1996-10-08 | 2008-10-16 | University Of Washington, Seattle | Therapeutische anwendungen von laminin und von proteinfragmenten die von laminin abgeleitet sind |
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-
1999
- 1999-02-13 DE DE19906096A patent/DE19906096A1/de not_active Ceased
-
2000
- 2000-01-27 AT AT00901137T patent/ATE470713T1/de not_active IP Right Cessation
- 2000-01-27 US US09/913,467 patent/US7253254B1/en not_active Expired - Fee Related
- 2000-01-27 WO PCT/EP2000/000637 patent/WO2000047736A1/de active IP Right Grant
- 2000-01-27 DE DE50015938T patent/DE50015938D1/de not_active Expired - Lifetime
- 2000-01-27 CN CNB008037183A patent/CN1169959C/zh not_active Expired - Fee Related
- 2000-01-27 EP EP00901137A patent/EP1151095B1/de not_active Expired - Lifetime
- 2000-01-27 CA CA2362496A patent/CA2362496C/en not_active Expired - Fee Related
- 2000-01-27 AU AU21106/00A patent/AU762387B2/en not_active Ceased
- 2000-01-27 RU RU2001123926/15A patent/RU2227743C2/ru not_active IP Right Cessation
- 2000-01-27 BR BR0008785-8A patent/BR0008785A/pt not_active Application Discontinuation
- 2000-01-27 JP JP2000598634A patent/JP4155711B2/ja not_active Expired - Fee Related
-
2007
- 2007-10-02 JP JP2007258333A patent/JP2008086319A/ja active Pending
-
2008
- 2008-08-05 JP JP2008201668A patent/JP2009011323A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
EP1151095B1 (de) | 2010-06-09 |
CA2362496A1 (en) | 2000-08-17 |
AU762387B2 (en) | 2003-06-26 |
JP2008086319A (ja) | 2008-04-17 |
CN1340102A (zh) | 2002-03-13 |
BR0008785A (pt) | 2001-11-06 |
EP1151095A1 (de) | 2001-11-07 |
CA2362496C (en) | 2011-04-19 |
US7253254B1 (en) | 2007-08-07 |
WO2000047736A1 (de) | 2000-08-17 |
AU2110600A (en) | 2000-08-29 |
ATE470713T1 (de) | 2010-06-15 |
JP4155711B2 (ja) | 2008-09-24 |
CN1169959C (zh) | 2004-10-06 |
RU2227743C2 (ru) | 2004-04-27 |
JP2002536016A (ja) | 2002-10-29 |
JP2009011323A (ja) | 2009-01-22 |
DE19906096A1 (de) | 2000-08-17 |
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