DE59310379D1 - Asparaginsäurederivate, ihre Herstellung und Verwendung - Google Patents
Asparaginsäurederivate, ihre Herstellung und VerwendungInfo
- Publication number
- DE59310379D1 DE59310379D1 DE59310379T DE59310379T DE59310379D1 DE 59310379 D1 DE59310379 D1 DE 59310379D1 DE 59310379 T DE59310379 T DE 59310379T DE 59310379 T DE59310379 T DE 59310379T DE 59310379 D1 DE59310379 D1 DE 59310379D1
- Authority
- DE
- Germany
- Prior art keywords
- alkyl
- phenyl
- substd
- alkoxy
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
- C07D295/215—Radicals derived from nitrogen analogues of carbonic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
- C07C279/08—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by singly-bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/34—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06104—Dipeptides with the first amino acid being acidic
- C07K5/06113—Asp- or Asn-amino acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
- C07K5/0806—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/582—Recycling of unreacted starting or intermediate materials
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE59310379T DE59310379D1 (de) | 1992-04-13 | 1993-03-18 | Asparaginsäurederivate, ihre Herstellung und Verwendung |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE4212304A DE4212304A1 (de) | 1992-04-13 | 1992-04-13 | Asparaginsäurederivate, ihre Herstellung und Verwendung |
DE59310379T DE59310379D1 (de) | 1992-04-13 | 1993-03-18 | Asparaginsäurederivate, ihre Herstellung und Verwendung |
Publications (1)
Publication Number | Publication Date |
---|---|
DE59310379D1 true DE59310379D1 (de) | 2005-12-01 |
Family
ID=6456690
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE4212304A Withdrawn DE4212304A1 (de) | 1992-04-13 | 1992-04-13 | Asparaginsäurederivate, ihre Herstellung und Verwendung |
DE59310379T Expired - Lifetime DE59310379D1 (de) | 1992-04-13 | 1993-03-18 | Asparaginsäurederivate, ihre Herstellung und Verwendung |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE4212304A Withdrawn DE4212304A1 (de) | 1992-04-13 | 1992-04-13 | Asparaginsäurederivate, ihre Herstellung und Verwendung |
Country Status (15)
Country | Link |
---|---|
US (1) | US5399570A (de) |
EP (2) | EP0784058B8 (de) |
JP (1) | JP3504287B2 (de) |
KR (1) | KR930021605A (de) |
AT (1) | ATE307825T1 (de) |
AU (1) | AU659299B2 (de) |
CA (1) | CA2093770C (de) |
CZ (1) | CZ290280B6 (de) |
DE (2) | DE4212304A1 (de) |
ES (1) | ES2250980T3 (de) |
HU (1) | HU218206B (de) |
IL (1) | IL105355A (de) |
SK (1) | SK282125B6 (de) |
TW (1) | TW267158B (de) |
ZA (1) | ZA932535B (de) |
Families Citing this family (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5169930A (en) * | 1990-01-05 | 1992-12-08 | La Jolla Cancer Research Foundation | Fibronectin receptor |
DK0513675T3 (da) * | 1991-05-13 | 1996-09-30 | Fujisawa Pharmaceutical Co | Hidtil ukendt peptidforbindelse samt fremgangsmåde til fremstilling deraf |
TW257757B (de) * | 1993-03-03 | 1995-09-21 | Boehringer Mannheim Gmbh | |
US5750754A (en) * | 1993-03-29 | 1998-05-12 | Zeneca Limited | Heterocyclic compounds |
US5753659A (en) * | 1993-03-29 | 1998-05-19 | Zeneca Limited | Heterocyclic compouds |
US5652242A (en) * | 1993-03-29 | 1997-07-29 | Zeneca Limited | Heterocyclic derivatives |
PT825184E (pt) * | 1993-03-29 | 2001-11-30 | Astrazeneca Ab | Derivados heterociclicos como inibidores de agregacao de plaquetas |
ZW4194A1 (en) * | 1993-03-29 | 1994-12-21 | Zeneca Ltd | Heterocyclic compounds |
GB9313268D0 (en) * | 1993-06-28 | 1993-08-11 | Zeneca Ltd | Chemical compounds |
GB9313285D0 (en) * | 1993-06-28 | 1993-08-11 | Zeneca Ltd | Acid derivatives |
US5463011A (en) * | 1993-06-28 | 1995-10-31 | Zeneca Limited | Acid derivatives |
US6274705B1 (en) * | 1996-05-02 | 2001-08-14 | Aventis Pharmaceuticals Products Inc. | Antithrombotic azacycloalkylalkanoyl peptides and pseudopeptides |
US5446056A (en) * | 1993-11-24 | 1995-08-29 | The Du Pont Merck Pharmaceutical Company | Isoxazoline compounds useful as fibrinogen receptor antagonists |
US5849736A (en) * | 1993-11-24 | 1998-12-15 | The Dupont Merck Pharmaceutical Company | Isoxazoline and isoxazole fibrinogen receptor antagonists |
US5523302A (en) * | 1993-11-24 | 1996-06-04 | The Du Pont Merck Pharmaceutical Company | Aromatic compounds containing basic and acidic termini useful as fibrinogen receptor antagonists |
US5563158A (en) * | 1993-12-28 | 1996-10-08 | The Dupont Merck Pharmaceutical Company | Aromatic compounds containing basic and acidic termini useful as fibrinogen receptor antagonists |
US7001921B1 (en) | 1995-01-23 | 2006-02-21 | Biogen Idec Ma Inc. | Cell adhesion inhibitors |
US6306840B1 (en) * | 1995-01-23 | 2001-10-23 | Biogen, Inc. | Cell adhesion inhibitors |
ZA963391B (en) * | 1995-05-24 | 1997-10-29 | Du Pont Merck Pharma | Isoxazoline fibrinogen receptor antagonists. |
US6248713B1 (en) | 1995-07-11 | 2001-06-19 | Biogen, Inc. | Cell adhesion inhibitors |
WO1997026250A1 (en) * | 1996-01-16 | 1997-07-24 | Merck & Co., Inc. | Integrin receptor antagonists |
US6239108B1 (en) | 1996-07-11 | 2001-05-29 | Biogen, Inc. | Cell adhesion inhibitors |
CA2261974A1 (en) | 1996-07-25 | 1998-02-05 | Biogen, Inc. | Molecular model for vla-4 inhibitors |
US6686350B1 (en) | 1996-07-25 | 2004-02-03 | Biogen, Inc. | Cell adhesion inhibitors |
US5759152A (en) * | 1996-10-02 | 1998-06-02 | Mayo Foundation For Medical Education And Research | Phase-aligned NMR surface coil image reconstruction |
US6458781B1 (en) * | 1998-04-27 | 2002-10-01 | David Thomas Connor | Substituted diarylalkyl amides as calcium channel antagonists |
CN1148350C (zh) | 1998-05-28 | 2004-05-05 | 拜奥根有限公司 | 新型VLA-4抑制剂:oMePUPA-V |
GEP20063956B (en) | 1999-08-13 | 2006-11-10 | Biogen Idec Inc | Cell adhesion inhibitors |
US6875743B1 (en) | 2000-11-28 | 2005-04-05 | Biogen, Inc. | Cell adhesion inhibitors |
DE10204789A1 (de) * | 2002-02-06 | 2003-08-14 | Merck Patent Gmbh | Inhibitoren des Integrins alpha¶v¶beta6 |
AU2004275821A1 (en) * | 2003-09-25 | 2005-04-07 | Dmi Biosciences Inc. | Methods and products which utilize N-acyl-L-aspartic acid |
MXPA06010756A (es) * | 2004-03-24 | 2006-12-15 | Jerini Ag | Nuevos compuestos para la inhibicion de la angiogenesis y su uso. |
US7196112B2 (en) * | 2004-07-16 | 2007-03-27 | Biogen Idec Ma Inc. | Cell adhesion inhibitors |
WO2006087232A1 (en) * | 2005-02-17 | 2006-08-24 | Instituto Del Metabolismo Celular, S.L. | L-aspartic acid for the treatment of problems in connection with the fat or glucose metabolism |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4879313A (en) * | 1988-07-20 | 1989-11-07 | Mosanto Company | Novel platelet-aggregation inhibitors |
US5039805A (en) * | 1988-12-08 | 1991-08-13 | Hoffmann-La Roche Inc. | Novel benzoic and phenylacetic acid derivatives |
US5084466A (en) * | 1989-01-31 | 1992-01-28 | Hoffmann-La Roche Inc. | Novel carboxamide pyridine compounds which have useful pharmaceutical utility |
US5318899A (en) * | 1989-06-16 | 1994-06-07 | Cor Therapeutics, Inc. | Platelet aggregation inhibitors |
US4952562A (en) * | 1989-09-29 | 1990-08-28 | Rorer Pharmaceutical Corporation | Anti-thrombotic peptides and pseudopeptides |
JPH05500954A (ja) * | 1989-09-29 | 1993-02-25 | ローヌ―プーラン ローラー インターナショナル(ホウルディングス) インコーポレイテッド | 抗血栓性ペプチド及び疑似ペプチド |
US5051405A (en) * | 1989-10-10 | 1991-09-24 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Anti-thrombotic peptides and pseudopeptides |
US5086069A (en) * | 1990-02-05 | 1992-02-04 | Rorer Pharmaceutical Corporation | Anti-thrombotic peptide and pseudopeptide derivatives |
US5264420A (en) * | 1990-09-27 | 1993-11-23 | Merck & Co., Inc. | Fibrinogen receptor antagonists |
EP0574545B1 (de) * | 1991-03-06 | 1994-11-30 | G.D. Searle & Co. | Phenylamidinderivate als plättchenaggregationsinhibitoren |
US5227490A (en) * | 1992-02-21 | 1993-07-13 | Merck & Co., Inc. | Fibrinogen receptor antagonists |
-
1992
- 1992-04-13 DE DE4212304A patent/DE4212304A1/de not_active Withdrawn
-
1993
- 1993-03-18 EP EP96102404A patent/EP0784058B8/de not_active Expired - Lifetime
- 1993-03-18 DE DE59310379T patent/DE59310379D1/de not_active Expired - Lifetime
- 1993-03-18 EP EP93104415A patent/EP0565896A2/de not_active Withdrawn
- 1993-03-18 AT AT96102404T patent/ATE307825T1/de not_active IP Right Cessation
- 1993-03-18 ES ES96102404T patent/ES2250980T3/es not_active Expired - Lifetime
- 1993-03-22 TW TW082102118A patent/TW267158B/zh active
- 1993-03-24 CZ CZ1993494A patent/CZ290280B6/cs not_active IP Right Cessation
- 1993-03-25 US US08/036,923 patent/US5399570A/en not_active Expired - Lifetime
- 1993-04-08 CA CA002093770A patent/CA2093770C/en not_active Expired - Lifetime
- 1993-04-08 AU AU36836/93A patent/AU659299B2/en not_active Ceased
- 1993-04-08 ZA ZA932535A patent/ZA932535B/xx unknown
- 1993-04-09 IL IL105355A patent/IL105355A/en not_active IP Right Cessation
- 1993-04-09 SK SK334-93A patent/SK282125B6/sk unknown
- 1993-04-12 KR KR1019930006039A patent/KR930021605A/ko not_active Application Discontinuation
- 1993-04-12 JP JP08494693A patent/JP3504287B2/ja not_active Expired - Fee Related
- 1993-04-13 HU HU9301071A patent/HU218206B/hu not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
EP0784058A1 (de) | 1997-07-16 |
EP0565896A2 (de) | 1993-10-20 |
JP3504287B2 (ja) | 2004-03-08 |
HU9301071D0 (en) | 1993-06-28 |
CA2093770A1 (en) | 1993-10-14 |
US5399570A (en) | 1995-03-21 |
CZ290280B6 (cs) | 2002-07-17 |
AU659299B2 (en) | 1995-05-11 |
HU218206B (hu) | 2000-06-28 |
HUT64016A (en) | 1993-11-29 |
EP0784058B1 (de) | 2005-10-26 |
DE4212304A1 (de) | 1993-10-14 |
ATE307825T1 (de) | 2005-11-15 |
CA2093770C (en) | 2004-09-07 |
KR930021605A (ko) | 1993-11-22 |
IL105355A (en) | 1998-03-10 |
ZA932535B (en) | 1993-11-04 |
JPH07109256A (ja) | 1995-04-25 |
CZ49493A3 (en) | 1994-02-16 |
AU3683693A (en) | 1993-10-14 |
EP0565896A3 (de) | 1994-01-12 |
SK33493A3 (en) | 1994-02-02 |
EP0784058B8 (de) | 2005-12-28 |
SK282125B6 (sk) | 2001-11-06 |
ES2250980T3 (es) | 2006-04-16 |
TW267158B (de) | 1996-01-01 |
IL105355A0 (en) | 1993-08-18 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8327 | Change in the person/name/address of the patent owner |
Owner name: SANOFI-AVENTIS DEUTSCHLAND GMBH, 65929 FRANKFURT, |
|
8364 | No opposition during term of opposition |