DE60014381D1 - System zur aufrechterhaltung von gewebe - Google Patents
System zur aufrechterhaltung von gewebeInfo
- Publication number
- DE60014381D1 DE60014381D1 DE60014381T DE60014381T DE60014381D1 DE 60014381 D1 DE60014381 D1 DE 60014381D1 DE 60014381 T DE60014381 T DE 60014381T DE 60014381 T DE60014381 T DE 60014381T DE 60014381 D1 DE60014381 D1 DE 60014381D1
- Authority
- DE
- Germany
- Prior art keywords
- tissue
- scaffold
- medium
- sulfates
- cells
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
- A61L27/3691—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment characterised by physical conditions of the treatment, e.g. applying a compressive force to the composition, pressure cycles, ultrasonic/sonication or microwave treatment, lyophilisation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
- A61L27/3608—Bone, e.g. demineralised bone matrix [DBM], bone powder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
- A61L27/3612—Cartilage, synovial fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
- A61L27/3629—Intestinal tissue, e.g. small intestinal submucosa
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
- A61L27/3687—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment characterised by the use of chemical agents in the treatment, e.g. specific enzymes, detergents, capping agents, crosslinkers, anticalcification agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M21/00—Bioreactors or fermenters specially adapted for specific uses
- C12M21/08—Bioreactors or fermenters specially adapted for specific uses for producing artificial tissue or for ex-vivo cultivation of tissue
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M25/00—Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
- C12M25/14—Scaffolds; Matrices
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0062—General methods for three-dimensional culture
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0655—Chondrocytes; Cartilage
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/3094—Designing or manufacturing processes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/30756—Cartilage endoprostheses
- A61F2002/30762—Means for culturing cartilage
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/30756—Cartilage endoprostheses
- A61F2002/30766—Scaffolds for cartilage ingrowth and regeneration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2533/00—Supports or coatings for cell culture, characterised by material
- C12N2533/90—Substrates of biological origin, e.g. extracellular matrix, decellularised tissue
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2533/00—Supports or coatings for cell culture, characterised by material
- C12N2533/90—Substrates of biological origin, e.g. extracellular matrix, decellularised tissue
- C12N2533/92—Amnion; Decellularised dermis or mucosa
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/345,138 US6632651B1 (en) | 1999-07-06 | 1999-07-06 | Tissue maintenance system that applies rhythmic pulses of pressure |
PCT/IL2000/000386 WO2001002030A2 (en) | 1999-07-06 | 2000-07-04 | Scaffold matrix and tissue maintaining systems |
Publications (1)
Publication Number | Publication Date |
---|---|
DE60014381D1 true DE60014381D1 (de) | 2004-11-04 |
Family
ID=23353693
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60014381T Expired - Lifetime DE60014381D1 (de) | 1999-07-06 | 2000-07-04 | System zur aufrechterhaltung von gewebe |
Country Status (8)
Country | Link |
---|---|
US (1) | US6632651B1 (de) |
EP (1) | EP1196540B1 (de) |
JP (1) | JP2003503159A (de) |
AT (1) | ATE278009T1 (de) |
AU (1) | AU5561900A (de) |
CA (1) | CA2378209A1 (de) |
DE (1) | DE60014381D1 (de) |
WO (1) | WO2001002030A2 (de) |
Families Citing this family (38)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6652872B2 (en) | 1999-07-06 | 2003-11-25 | Ramat At Tel Aviv University Ltd. | Scaffold formed of tissue treated to eliminate cellular and cytosolic elements |
US6528052B1 (en) | 2000-09-29 | 2003-03-04 | The Board Of Trustees Of The Leland Stanford Junior University | Method for in vivo ex vivo and in vitro repair and regeneration of cartilage and collagen and bone remodeling |
DE60039336D1 (de) * | 2000-08-03 | 2008-08-14 | Koninkl Philips Electronics Nv | Fluid-Transport durch Druckvariation zur Analyse biologischer Flüssigkeiten |
JP4500898B2 (ja) * | 2001-03-23 | 2010-07-14 | 高木産業株式会社 | 生物学的組織および組織構築物を製造するための組成物および方法 |
US20040151705A1 (en) | 2002-03-22 | 2004-08-05 | Shuichi Mizuno | Neo-cartilage constructs and a method for preparation thereof |
US7468192B2 (en) * | 2002-03-22 | 2008-12-23 | Histogenics Corporation | Method for repair of cartilage lesions |
JP2005531300A (ja) * | 2002-04-08 | 2005-10-20 | ミレニアム・バイオロジクス,インコーポレイテッド | 自動的な組織工学モジュール |
US20040170950A1 (en) * | 2002-09-12 | 2004-09-02 | Prien Samuel D. | Organ preservation apparatus and methods |
AU2003900620A0 (en) * | 2003-02-12 | 2003-02-27 | Australian Surgical Design And Manufacture Pty Limited | Arthroscopic chondrocyte implantation method and device |
US7666230B2 (en) | 2003-12-08 | 2010-02-23 | Depuy Products, Inc. | Implant device for cartilage regeneration in load bearing articulation regions |
ES2404682T3 (es) | 2003-12-11 | 2013-05-28 | Isto Technologies Inc. | Sistema de cartílago particulado |
US20050153271A1 (en) * | 2004-01-13 | 2005-07-14 | Wenrich Marshall S. | Organ preservation apparatus and methods |
EP1730267B1 (de) * | 2004-03-05 | 2013-01-16 | Octane Biotech Inc. | Umkehrflussperfusion dreidimensionaler gerüste |
US7776392B2 (en) * | 2005-04-15 | 2010-08-17 | Siemens Energy, Inc. | Composite insulation tape with loaded HTC materials |
US7767446B2 (en) * | 2004-09-16 | 2010-08-03 | Becton, Dickinson And Company | Perfusion bioreactors for culturing cells |
US9427496B2 (en) | 2005-02-18 | 2016-08-30 | Drexel University | Method for creating an internal transport system within tissue scaffolds using computer-aided tissue engineering |
WO2007025290A2 (en) | 2005-08-26 | 2007-03-01 | Isto Technologies, Inc. | Implants and methods for repair, replacement and treatment of joint disease |
JP2009507103A (ja) * | 2005-09-02 | 2009-02-19 | コルバー・ライフサイエンス・リミテツド | 架橋多糖およびタンパク質マトリックスならびにそれらの製造方法 |
EP1926459B1 (de) | 2005-09-19 | 2015-01-07 | Histogenics Corporation | Zellunterstützende matrix mit eng definierter, gleichmässig senkrecht und nicht zufällig organisierter porosität und porendichte und verfahren zur herstellung davon |
US9944900B2 (en) * | 2006-01-18 | 2018-04-17 | Hemacell Perfusion | Pulsatile perfusion extraction method for non-embryonic pluripotent stem cells |
EP2049159A4 (de) * | 2006-08-11 | 2011-08-17 | Univ Queensland | Gerüst-behandlung vorrichtung und verfahren |
US20080145919A1 (en) * | 2006-12-18 | 2008-06-19 | Franklin Thomas D | Portable organ and tissue preservation apparatus, kit and methods |
CA2684040C (en) | 2007-04-12 | 2016-12-06 | Isto Technologies, Inc. | Method of forming an implant using a mold that mimics the shape of the tissue defect site and implant formed therefrom |
US8685107B2 (en) | 2007-07-03 | 2014-04-01 | Histogenics Corporation | Double-structured tissue implant and a method for preparation and use thereof |
US20090054984A1 (en) | 2007-08-20 | 2009-02-26 | Histogenics Corporation | Method For Use Of A Double-Structured Tissue Implant For Treatment Of Tissue Defects |
EP2182887B1 (de) | 2007-08-20 | 2016-12-14 | Histogenics Corporation | Verfahren für verbesserte differenzierung mesenchymaler stammzellen anhand eines doppelstrukturierten gewebeimplantats |
US9687348B2 (en) | 2009-03-03 | 2017-06-27 | The Trustees Of Columbia University In The City Of New York | Method of making a personalized bone graft |
US9606035B2 (en) | 2011-12-21 | 2017-03-28 | Ta Instruments-Waters Llc | System for mechanical stimulation and characterization of biologic samples |
US20140178343A1 (en) | 2012-12-21 | 2014-06-26 | Jian Q. Yao | Supports and methods for promoting integration of cartilage tissue explants |
US10160944B2 (en) | 2014-08-05 | 2018-12-25 | The Charles Stark Draper Laboratory, Inc. | Fluid circulation systems incorporating fluid leveling devices |
US10077420B2 (en) | 2014-12-02 | 2018-09-18 | Histogenics Corporation | Cell and tissue culture container |
KR102447734B1 (ko) | 2017-04-07 | 2022-09-28 | 에피본, 인크. | 접종 및 배양용 시스템 및 방법 |
CN111373030A (zh) | 2017-09-01 | 2020-07-03 | 隆萨沃克斯维尔股份有限公司 | 端到端细胞治疗自动化 |
US11718833B2 (en) | 2018-12-21 | 2023-08-08 | Lonza Walkersville, Inc. | Automated production of viral vectors |
CA3123314A1 (en) | 2018-12-21 | 2020-06-25 | Octane Biotech Inc. | Carousel for modular biologic production units |
EP3902906A4 (de) | 2018-12-28 | 2022-11-09 | Octane Biotech Inc. | Zellkultur- und gewebezüchtungssysteme mit kontrollierten umweltzonen |
SG11202108473XA (en) | 2019-02-08 | 2021-09-29 | Lonza Walkersville Inc | Cell concentration methods and devices for use in automated bioreactors |
US11896736B2 (en) | 2020-07-13 | 2024-02-13 | Globus Medical, Inc | Biomaterial implants and methods of making the same |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4880429A (en) | 1987-07-20 | 1989-11-14 | Stone Kevin R | Prosthetic meniscus |
US5108438A (en) | 1989-03-02 | 1992-04-28 | Regen Corporation | Prosthetic intervertebral disc |
US4851354A (en) | 1987-12-07 | 1989-07-25 | Trustees Of The University Of Pennsylvania | Apparatus for mechanically stimulating cells |
US5162114A (en) | 1989-02-23 | 1992-11-10 | Stryker Corporation | Bone collagen matrix for xenogenic implants |
JP3080647B2 (ja) * | 1990-10-09 | 2000-08-28 | エーザイ株式会社 | 細胞培養装置 |
EP0571527B1 (de) | 1991-02-14 | 1996-04-24 | Baxter International Inc. | Herstellungsverfahren für biegsame biologische Gewebeverpflanzungsmaterialen |
EP1452153A1 (de) | 1994-03-14 | 2004-09-01 | Cryolife, Inc | Vorbehandeltes Gewebe für die Implantation und ein Verfahren |
US5792603A (en) | 1995-04-27 | 1998-08-11 | Advanced Tissue Sciences, Inc. | Apparatus and method for sterilizing, seeding, culturing, storing, shipping and testing tissue, synthetic or native, vascular grafts |
US6048964A (en) | 1995-12-12 | 2000-04-11 | Stryker Corporation | Compositions and therapeutic methods using morphogenic proteins and stimulatory factors |
US6165487A (en) | 1996-09-30 | 2000-12-26 | Children's Medical Center Corporation | Methods and compositions for programming an organic matrix for remodeling into a target tissue |
EP0929322A1 (de) | 1996-09-30 | 1999-07-21 | Children's Medical Center Corporation | Verfahren und zusammensetzungen zur programmierung einer organische matrix für remodellierung in ein ziel-gewebe |
US5928945A (en) | 1996-11-20 | 1999-07-27 | Advanced Tissue Sciences, Inc. | Application of shear flow stress to chondrocytes or chondrocyte stem cells to produce cartilage |
DE19808055B4 (de) | 1998-02-27 | 2007-02-08 | Adamietz, Peter, Dr.rer.nat. | Verfahren und Apparatur zur Herstellung von dreidimensionalen Gewebezellkulturen |
US6037141A (en) | 1998-06-04 | 2000-03-14 | Banes; Albert J. | Culture compression device |
IL144187A0 (en) | 1999-01-14 | 2002-05-23 | Advanced Tissue Sciences Inc | Apparatus and method for sterilizing, seeding, culturing, storing, shipping and testing tissue, synthetic, or native vascular grafts |
-
1999
- 1999-07-06 US US09/345,138 patent/US6632651B1/en not_active Expired - Fee Related
-
2000
- 2000-07-04 EP EP00940721A patent/EP1196540B1/de not_active Expired - Lifetime
- 2000-07-04 WO PCT/IL2000/000386 patent/WO2001002030A2/en active IP Right Grant
- 2000-07-04 AU AU55619/00A patent/AU5561900A/en not_active Abandoned
- 2000-07-04 JP JP2001507520A patent/JP2003503159A/ja active Pending
- 2000-07-04 AT AT00940721T patent/ATE278009T1/de not_active IP Right Cessation
- 2000-07-04 CA CA002378209A patent/CA2378209A1/en not_active Abandoned
- 2000-07-04 DE DE60014381T patent/DE60014381D1/de not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
JP2003503159A (ja) | 2003-01-28 |
EP1196540A2 (de) | 2002-04-17 |
WO2001002030A2 (en) | 2001-01-11 |
CA2378209A1 (en) | 2001-01-11 |
EP1196540B1 (de) | 2004-09-29 |
ATE278009T1 (de) | 2004-10-15 |
AU5561900A (en) | 2001-01-22 |
US6632651B1 (en) | 2003-10-14 |
WO2001002030A3 (en) | 2001-08-23 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE60014381D1 (de) | System zur aufrechterhaltung von gewebe | |
DE69622575T2 (de) | Photovernetztes hyaluronsäuregel und verfahren zu dessen herstellung | |
ATE87452T1 (de) | Prothese fuer meniscus. | |
CA2435491A1 (en) | Crosslinked polysaccharide sponge | |
ATE290892T1 (de) | Brustgewebetechnologie | |
DE69302823T2 (de) | Kieselsäuresole, verfahren zur herstellung von kieselsäuresolen und verwendung von diesen solen | |
DE3863011D1 (de) | Biomaterialien aus mischungen von kollagen mit chitosan und glycosaminoglykanen, verfahren zu ihrer herstellung und ihre verwendung in der humanmedizin. | |
BR9915463A (pt) | Resina funcional de carbamato tendo um sìtio de tratamento com sal catiÈnico | |
ATE311437T1 (de) | Verwendung von wachstumsfaktoren und hormonen zur vermehrung menschlicher chondrozyten und knorpelgewebeherstellung | |
ATE265191T1 (de) | Herstellungsverfahren von gewebe zur implantation | |
ATE284229T1 (de) | Funktionalisierte hyaluronsäurederivate, bildung von hydrogelen und deren verwendung in situ | |
ATE242018T1 (de) | Poröse kompositmatrix, deren herstellung und verwendung | |
ATE264689T1 (de) | Herstellung von kollagen | |
KR970704459A (ko) | 경조직 자극제(Hard Tissue Stimulating Agent) | |
ATE526393T1 (de) | Mesenchymale stammzellen für reparatur von knorpelgewebe | |
BR9805900A (pt) | Processo para integrar um fragmento de dna no genoma de uma c-lula de uma planta manocot¡ledonea e composi-Æo para o meio de crescimento de plantas | |
BR0312077B8 (pt) | método de despolimerização de polissacarídeos | |
DE602004030254D1 (de) | Scaffoldfreies, selbstorganisiertes, 3 dimensionales, synthetisches gewebe | |
JP2007519755A5 (de) | ||
AU2115200A (en) | Fibres | |
CN105037529A (zh) | 透明质酸寡糖修饰的胶原蛋白新型生物材料及其制备方法 | |
CN102351957B (zh) | 高氧化度的天然高分子多糖的氧化方法 | |
DE69115889D1 (de) | Ein neues hochdichtes hefepräparat, methode zu dessen herstellung und dessen verwendung | |
ATE164585T1 (de) | Kristallisationsverfahren zur herstellung von glycerophosphocholin | |
SE9700983D0 (sv) | Stimulering, odling och preservation av pankreas- och andra celler |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
8332 | No legal effect for de |