DE60024612D1 - Verfahren zur herstellung von konditionierten zellkulturmedium-zusammensetzungen - Google Patents

Verfahren zur herstellung von konditionierten zellkulturmedium-zusammensetzungen

Info

Publication number
DE60024612D1
DE60024612D1 DE60024612T DE60024612T DE60024612D1 DE 60024612 D1 DE60024612 D1 DE 60024612D1 DE 60024612 T DE60024612 T DE 60024612T DE 60024612 T DE60024612 T DE 60024612T DE 60024612 D1 DE60024612 D1 DE 60024612D1
Authority
DE
Germany
Prior art keywords
medium
conditioned
cell culture
culture medium
medium compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60024612T
Other languages
English (en)
Other versions
DE60024612T2 (de
Inventor
K Naughton
L Horwitz
A Applegate
Joan Zeltinger
N Mansbridge
Andreas Kern
K Landeen
Anthony Ratcliffe
Emmett Pinney
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SkinMedica Inc
Original Assignee
SkinMedica Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23216124&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE60024612(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by SkinMedica Inc filed Critical SkinMedica Inc
Application granted granted Critical
Publication of DE60024612D1 publication Critical patent/DE60024612D1/de
Publication of DE60024612T2 publication Critical patent/DE60024612T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/33—Fibroblasts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/35—Fat tissue; Adipocytes; Stromal cells; Connective tissues
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/36—Skin; Hair; Nails; Sebaceous glands; Cerumen; Epidermis; Epithelial cells; Keratinocytes; Langerhans cells; Ectodermal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/48—Reproductive organs
    • A61K35/50—Placenta; Placental stem cells; Amniotic fluid; Amnion; Amniotic stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1825—Fibroblast growth factor [FGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/39—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/0208—Tissues; Wipes; Patches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A61K8/65—Collagen; Gelatin; Keratin; Derivatives or degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
    • A61K8/981—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of mammals or bird
    • A61K8/985—Skin or skin outgrowth, e.g. hair, nails
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04—Macromolecular materials
    • A61L31/043—Proteins; Polypeptides; Degradation products thereof
    • A61L31/044—Collagen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04—Macromolecular materials
    • A61L31/043—Proteins; Polypeptides; Degradation products thereof
    • A61L31/047—Other specific proteins or polypeptides not covered by A61L31/044 - A61L31/046
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/16—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/16—Emollients or protectives, e.g. against radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/18—Antioxidants, e.g. antiradicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q7/00—Preparations for affecting hair growth
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0603—Embryonic cells ; Embryoid bodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0603—Embryonic cells ; Embryoid bodies
    • C12N5/0606—Pluripotent embryonic cells, e.g. embryonic stem cells [ES]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0625—Epidermal cells, skin cells; Cells of the oral mucosa
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0625—Epidermal cells, skin cells; Cells of the oral mucosa
    • C12N5/0629—Keratinocytes; Whole skin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0656—Adult fibroblasts
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/069—Vascular Endothelial cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/86—Products or compounds obtained by genetic engineering
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/91—Injection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/412—Tissue-regenerating or healing or proliferative agents
    • A61L2300/414—Growth factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/36—Materials or treatment for tissue regeneration for embolization or occlusion, e.g. vaso-occlusive compositions or devices
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/13—Coculture with; Conditioned medium produced by connective tissue cells; generic mesenchyme cells, e.g. so-called "embryonic fibroblasts"
    • C12N2502/1323—Adult fibroblasts
DE60024612T 1999-05-14 2000-05-12 Verfahren zur herstellung von konditionierten zellkulturmedium-zusammensetzungen Expired - Lifetime DE60024612T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/313,538 US6372494B1 (en) 1999-05-14 1999-05-14 Methods of making conditioned cell culture medium compositions
US313538 1999-05-14
PCT/US2000/013016 WO2000069449A2 (en) 1999-05-14 2000-05-12 Conditioned cell culture medium compositions and methods of use

Publications (2)

Publication Number Publication Date
DE60024612D1 true DE60024612D1 (de) 2006-01-12
DE60024612T2 DE60024612T2 (de) 2006-09-14

Family

ID=23216124

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60024612T Expired - Lifetime DE60024612T2 (de) 1999-05-14 2000-05-12 Verfahren zur herstellung von konditionierten zellkulturmedium-zusammensetzungen

Country Status (16)

Country Link
US (12) US6372494B1 (de)
EP (1) EP1178812B1 (de)
JP (2) JP5138129B2 (de)
CN (1) CN1198628C (de)
AT (1) ATE311894T1 (de)
AU (1) AU772829C (de)
BR (1) BR0010568A (de)
CA (1) CA2373302C (de)
DE (1) DE60024612T2 (de)
ES (1) ES2254176T3 (de)
HU (1) HUP0201887A2 (de)
MX (1) MXPA01011487A (de)
NZ (1) NZ515476A (de)
RU (1) RU2280459C2 (de)
WO (1) WO2000069449A2 (de)
ZA (1) ZA200109381B (de)

Families Citing this family (312)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6667176B1 (en) * 2000-01-11 2003-12-23 Geron Corporation cDNA libraries reflecting gene expression during growth and differentiation of human pluripotent stem cells
US7410798B2 (en) 2001-01-10 2008-08-12 Geron Corporation Culture system for rapid expansion of human embryonic stem cells
US20030007954A1 (en) * 1999-04-12 2003-01-09 Gail K. Naughton Methods for using a three-dimensional stromal tissue to promote angiogenesis
US6372494B1 (en) * 1999-05-14 2002-04-16 Advanced Tissue Sciences, Inc. Methods of making conditioned cell culture medium compositions
CA2383398C (en) * 1999-08-23 2013-06-11 Organogenesis, Inc. Skin care compositions and treatments
DE10005329A1 (de) * 2000-02-08 2001-09-20 Albert Scheller Humanisiertes, vitalisiertes Haarbewachsen und Haarwiederbewachsen mit subkutanen Kanüleneinstich-Haut-Färbungs-Zeichnungsverfahren
IL136232A0 (en) * 2000-05-18 2001-05-20 Bar Ilan University Res Author Measurements of enzymatic activity in a single, individual cell in population
WO2001091773A2 (en) * 2000-05-31 2001-12-06 Encelle, Inc. Method of stimulating hair growth
WO2002059278A2 (en) * 2001-01-24 2002-08-01 The Government Of The United States Of America, As Represented By The Secretary Of Department Of Health & Human Services Differentiation of stem cells to pancreatic endocrine cells
US20030211605A1 (en) * 2001-05-01 2003-11-13 Lee Sang-Hun Derivation of midbrain dopaminergic neurons from embryonic stem cells
WO2002098365A2 (en) * 2001-06-07 2002-12-12 Skinmedica, Inc. Conditioned cell culture media and uses thereof
JP2003012525A (ja) * 2001-07-02 2003-01-15 Hoshizaki Electric Co Ltd 生体の損傷部位用の洗浄水およびその製造装置
US20030068297A1 (en) * 2001-08-18 2003-04-10 Deepak Jain Composition and methods for skin rejuvenation and repair
US20040265268A1 (en) * 2001-08-18 2004-12-30 Deepak Jain Compositions and methods for skin rejuvenation and repair
EP2332651A3 (de) * 2001-10-25 2011-08-31 Bar Ilan University Interaktiver transparenter Biochip-Prozessor für einzeln adressierbare Zellen
WO2003057152A2 (en) * 2001-12-31 2003-07-17 Isolagen Technologies, Inc Hair follicle growth
WO2004007699A2 (en) * 2002-07-16 2004-01-22 Biogentis Inc. Method for preparing engineered tissue
WO2004011631A2 (en) * 2002-07-26 2004-02-05 Ebi, L.P. Methods and compositions for treating tissue defects using pulsed electromagnetic field stimulus
US20050019747A1 (en) * 2002-08-07 2005-01-27 Anderson Daniel G. Nanoliter-scale synthesis of arrayed biomaterials and screening thereof
US7338433B2 (en) 2002-08-13 2008-03-04 Allergan, Inc. Remotely adjustable gastric banding method
JP2005536214A (ja) * 2002-08-22 2005-12-02 セルトラン リミテッド 細胞培養表面
DE60331457D1 (de) 2002-08-28 2010-04-08 Allergan Inc Ermüdungsfeste magenbandvorrichtung
US7785876B2 (en) * 2002-11-14 2010-08-31 Aderans Research Institute, Inc. Cultivation of hair inductive cells
IL154677A0 (en) * 2003-02-27 2003-09-17 Univ Bar Ilan A method and apparatus for manipulating an individual cell
AU2004227342B2 (en) * 2003-04-01 2011-01-20 United States Of America Department Of Veteran's Affairs Stem-cell, precursor cell, or target cell-based treatment of multi-organ failure and renal dysfunction
FR2861734B1 (fr) 2003-04-10 2006-04-14 Corneal Ind Reticulation de polysaccharides de faible et forte masse moleculaire; preparation d'hydrogels monophasiques injectables; polysaccharides et hydrogels obtenus
FR2853905A1 (fr) * 2003-04-15 2004-10-22 Corbin Assia Eljaafari Production de cellules dendritiques humaines derivees de monocytes, a l'aide de cellules souches mesenchymateuses
EP1475434A1 (de) * 2003-05-09 2004-11-10 Oncoscience AG Verfahren zur Lagerung von Tumorzellen
EP2340856B2 (de) * 2003-05-24 2017-11-15 La Prairie Group AG Kosmetische oder dermatologische Zubereitung umfassend eine Nährmedienphase
US9200245B2 (en) 2003-06-26 2015-12-01 Seng Enterprises Ltd. Multiwell plate
US8597597B2 (en) * 2003-06-26 2013-12-03 Seng Enterprises Ltd. Picoliter well holding device and method of making the same
US20060240548A1 (en) * 2003-06-26 2006-10-26 Mordechai Deutsch Materials for constructing cell-chips, cell-chip covers, cell-chips coats, processed cell-chips and uses thereof
US7888110B2 (en) * 2003-06-26 2011-02-15 Seng Enterprises Ltd. Pico liter well holding device and method of making the same
US7875272B2 (en) 2003-06-27 2011-01-25 Ethicon, Incorporated Treatment of stroke and other acute neuraldegenerative disorders using postpartum derived cells
US9572840B2 (en) 2003-06-27 2017-02-21 DePuy Synthes Products, Inc. Regeneration and repair of neural tissue using postpartum-derived cells
US8790637B2 (en) 2003-06-27 2014-07-29 DePuy Synthes Products, LLC Repair and regeneration of ocular tissue using postpartum-derived cells
US8491883B2 (en) * 2003-06-27 2013-07-23 Advanced Technologies And Regenerative Medicine, Llc Treatment of amyotrophic lateral sclerosis using umbilical derived cells
US8518390B2 (en) 2003-06-27 2013-08-27 Advanced Technologies And Regenerative Medicine, Llc Treatment of stroke and other acute neural degenerative disorders via intranasal administration of umbilical cord-derived cells
US8703121B2 (en) * 2003-06-27 2014-04-22 DePuy Synthes Products, LLC Postpartum-derived cells for use in treatment of disease of the heart and circulatory system
US9592258B2 (en) 2003-06-27 2017-03-14 DePuy Synthes Products, Inc. Treatment of neurological injury by administration of human umbilical cord tissue-derived cells
US7982751B2 (en) * 2003-07-11 2011-07-19 The University Of North Carolina Methods and systems for controlling a computer using a video image and for combining the video image with a computer desktop
IL156945A0 (en) * 2003-07-15 2004-02-08 Itzhak Tavori Device and a method for orthopedic delivery of bone reconstruction medium
US20050064524A1 (en) * 2003-08-11 2005-03-24 Mordechai Deutsch Population of cells utilizable for substance detection and methods and devices using same
ITRM20030395A1 (it) * 2003-08-12 2005-02-13 Istituto Naz Per Le Malattie Infettive Lazz Terreno di coltura per il mantenimento, la proliferazione e il differenziamento di cellule di mammifero.
WO2005016364A1 (en) * 2003-08-14 2005-02-24 Guthy-Renker Corporation Skin care composition including hexapeptide complexes and methods of their manufacture
US20060198800A1 (en) * 2003-08-14 2006-09-07 Natalie Dilallo Skin care compositions including hexapeptide complexes and methods of their manufacture
WO2005062791A2 (en) * 2003-12-20 2005-07-14 Jeffrey Sebastian Utilization of stem cell and fibroblast combined products and nutrients in topical compositions
PL380451A1 (pl) 2004-01-23 2007-02-05 Allergan, Inc. Jednoelementowa regulowana opaska żołądkowa, mocowana z możliwością zwolnienia
US7544805B2 (en) * 2004-02-03 2009-06-09 Chemagis Ltd. Stable amorphous forms of montelukast sodium
EP1718733A4 (de) * 2004-02-06 2007-02-07 Theradigm Inc Zusammensetzungen und verfahren in verbindung mit der kultivierung neuraler stammzellen mit knochenmarksstromazellen
MXPA06010204A (es) 2004-03-08 2007-03-07 Endoart Sa Sistema de cierre para organos tubulares.
US20080063251A1 (en) * 2004-07-07 2008-03-13 Mordechai Deutsch Method and Device for Identifying an Image of a Well in an Image of a Well-Bearing
US7403647B2 (en) * 2004-09-13 2008-07-22 Seng Enterprises Ltd. Method for identifying an image of a well in an image of a well-bearing component
WO2006021959A2 (en) * 2004-08-25 2006-03-02 Seng Enterprises Ltd. Method and device for isolating cells
US20060154365A1 (en) * 2004-08-30 2006-07-13 Anthony Ratcliffe Cultured three dimensional tissues and uses thereof
EP1789536A2 (de) * 2004-08-30 2007-05-30 IKEN Tissue Therapeutics, Inc. Dreidimensionale kultivierte gewebe und deren verwendung
WO2006029262A2 (en) * 2004-09-08 2006-03-16 Myocardial Therapeutics, Inc. Conditioned medium of autologous or allogenic progenitor cells for angiogenesis treatment
JP5031370B2 (ja) * 2004-09-17 2012-09-19 セルジェンテック株式会社 外用皮膚潰瘍治療剤
US20060095121A1 (en) * 2004-10-28 2006-05-04 Medtronic Vascular, Inc. Autologous platelet gel on a stent graft
US7993578B2 (en) 2004-10-29 2011-08-09 Depuy Spine, Inc. Methods and kits for aseptic filling of products
WO2006083394A2 (en) * 2004-12-21 2006-08-10 Ethicon, Inc. Postpartum cells derived from placental tissue, and methods of making, culturing, and using the same
US20060171930A1 (en) * 2004-12-21 2006-08-03 Agnieszka Seyda Postpartum cells derived from umbilical cord tissue, and methods of making, culturing, and using the same
US20060153815A1 (en) * 2004-12-21 2006-07-13 Agnieszka Seyda Tissue engineering devices for the repair and regeneration of tissue
CA2589063C (en) 2004-12-23 2016-08-09 Ethicon Incorporated Treatment of parkinson's disease and related disorders using postpartum derived cells
JP5340599B2 (ja) * 2004-12-23 2013-11-13 エシコン・インコーポレイテッド 臍帯組織由来産褥細胞ならびにその製造方法および使用方法
US8038964B2 (en) * 2005-01-25 2011-10-18 Seng Enterprises Ltd. Device for studying individual cells
CN103356705B (zh) 2005-03-31 2015-09-30 斯丹姆涅恩有限公司 制备用以治疗烧伤伤口的药物的方法
US8153430B2 (en) * 2005-03-31 2012-04-10 Stemnion, Inc. Methods related to surgery
US8251888B2 (en) 2005-04-13 2012-08-28 Mitchell Steven Roslin Artificial gastric valve
NZ536009A (en) * 2005-04-18 2007-01-26 Neurotrophincell Pty Ltd Choroid plexus preparation and uses thereof
US20090075375A1 (en) * 2005-04-18 2009-03-19 Neurotrophincell Pty Limited Choroid plexus preparation and uses thereof
WO2006121445A2 (en) * 2005-05-10 2006-11-16 United States Of America Department Of Veteran's Affairs Therapy of kidney diseases and multiorgan failure with mesenchymal stem cells and mesenchymal stem cell conditioned media
NZ540597A (en) * 2005-06-08 2007-02-23 Neurotrophincell Pty Ltd A method for preventing the onset of type I diabetes comprising administering an implantable composition comprising living choroid plexus cells
CA2612188A1 (en) * 2005-06-17 2007-01-04 Theregen, Inc. Methods for treating ischemic tissue
US20070003541A1 (en) * 2005-07-01 2007-01-04 Rodolfo Faudoa Methods and compositions for therapeutics
US20070128685A1 (en) * 2005-07-01 2007-06-07 Rodolfo Faudoa Methods and compositions for cell culture
US20070004036A1 (en) * 2005-07-01 2007-01-04 Rodolfo Faudoa Methods and compositions for keratinocyte culture
DE102005034043B4 (de) * 2005-07-18 2019-12-12 Südzucker Aktiengesellschaft Mannheim/Ochsenfurt Gemisch, enthaltend L-Carnitin und Trehalulose, sowie Produkt enthaltend das Gemisch
US20070141555A1 (en) * 2005-10-11 2007-06-21 Mordechai Deutsch Current damper for the study of cells
WO2007052245A1 (en) * 2005-11-03 2007-05-10 Seng Enterprises Ltd. Method and device for studying floating, living cells
US20070231901A1 (en) * 2005-12-02 2007-10-04 Shuichi Takayama Microfluidic cell culture media
RU2008128451A (ru) * 2005-12-14 2010-01-20 Огенодженесис, Инк. (US) Композиция для лечения и ухода за кожей, способ ее получения, способ ее использования
US9175261B2 (en) * 2005-12-16 2015-11-03 DePuy Synthes Products, Inc. Human umbilical cord tissue cells for inhibiting adverse immune response in histocompatibility-mismatched transplantation
ES2391034T3 (es) * 2005-12-19 2012-11-20 Ethicon, Inc. Expansión in vitro de células derivadas postparto en frascos rotatorios
US9125906B2 (en) 2005-12-28 2015-09-08 DePuy Synthes Products, Inc. Treatment of peripheral vascular disease using umbilical cord tissue-derived cells
US20070160588A1 (en) * 2005-12-28 2007-07-12 Ethicon, Incorporated Treatment Of Peripheral Vascular Disease Using Postpartum-Derived Cells
US8043206B2 (en) 2006-01-04 2011-10-25 Allergan, Inc. Self-regulating gastric band with pressure data processing
US8871198B2 (en) * 2006-03-29 2014-10-28 Stemnion, Inc. Methods related to wound healing
EP1974022B1 (de) * 2006-01-27 2015-12-23 Prostemics Co., Ltd. Massenproduktionsverfahren für wachstumsfaktor unter verwendung von aus fettgewebe stammenden adulten stammzellen
JP2009525837A (ja) * 2006-02-07 2009-07-16 オルガノジェネシス インク． 生物工学処理された組織構築物およびその心臓での使用
WO2007097993A2 (en) * 2006-02-16 2007-08-30 The Burnham Institute Of Medical Research Media conditioned by human embryonic stem cells or other progenitor cells and uses therefor
US20110091568A1 (en) * 2006-02-16 2011-04-21 Lipton Stuart A Media conditioned by stem cells and uses therefor
EP2009096B8 (de) * 2006-04-04 2017-01-25 Trans-Technologies Ltd. Biotransplantat für die zelltherapie auf der grundlage mesenchymaler knochenmark-stammzellen
US20060223999A1 (en) * 2006-05-10 2006-10-05 Chemagis Ltd. Process for preparing montelukast and precursors thereof
FR2901136B1 (fr) * 2006-05-18 2010-10-01 Centre Nat Rech Scient Utilisation de cellules derivees du tissu adipeux pour la preparation d'un medicament anti-tumoral
US20080027212A1 (en) * 2006-06-28 2008-01-31 Skinner Keith K Methods and compositions for improved uptake of biological molecules
US20080166804A1 (en) * 2006-07-14 2008-07-10 Shamblott Michael J Compostions and methods for growing human embryonic stem cells
JP2007050263A (ja) * 2006-08-23 2007-03-01 Nipro Corp 生体組織または器官再生用器具
WO2008027984A1 (en) 2006-08-29 2008-03-06 Isolagen Technologies, Inc. Methods for culturing minimally-passaged fibroblasts and uses thereof
EP2076589B1 (de) 2006-10-02 2017-02-22 Orthocell Limited Verfahren zur herstellung nativer komponenten, wie etwa wachstumsfaktoren oder extrazellulärer matrixproteine, über zellkultivierung von gewebeproben für die gewebereparatur
ES2583371T3 (es) 2006-10-11 2016-09-20 The General Hospital Corporation Composiciones, métodos, y dispositivos para tratar enfermedades hepáticas
WO2008067422A2 (en) * 2006-11-28 2008-06-05 Zgi, Inc. Replication of undifferentiated diploid cells in a weightless environment, uses thereof and a facility for such replication
EP2099901B1 (de) 2006-11-30 2015-09-09 Medipost, Co., Ltd. Verwendung einer zusammensetzung mit aus menschlichem nabelschnurblut stammender mesenchymaler stammzelle zur induktion der differenzierung und proliferation neuraler vorläuferzellen oder neuraler stammzellen zu neuralen zellen
WO2008070868A1 (en) * 2006-12-07 2008-06-12 American Symbolic, Llc Stem cell secretions and related methods
US20080311093A1 (en) * 2006-12-07 2008-12-18 American Symbolic, Llc Stem cell secretions and related methods
US20120034183A1 (en) * 2006-12-19 2012-02-09 Michael Cohen Compositions and methods for growing embryonic stem cells
US20100130415A1 (en) * 2006-12-19 2010-05-27 Michael Cohen Stem cell secreted product derived compositions for wound treatment
RU2341270C2 (ru) * 2006-12-28 2008-12-20 Александр Сергеевич Ботин Композиция для стимулирования роста и регенерации клеток, а также способы ее получения
ES2623141T3 (es) 2007-01-17 2017-07-10 Noveome Biotherapeutics, Inc. Nuevos métodos para modular respuestas inflamatorias y/o inmunitarias
KR100883565B1 (ko) * 2007-02-14 2009-02-13 (주)프로스테믹스 지방 줄기세포의 조직 재생 능력을 최적화한 조건 배지를 함유한 조직 재생용 주사제 첨가제
WO2008103462A2 (en) 2007-02-23 2008-08-28 Advanced Cell Technology, Inc. Highly efficient methods for reprogramming differentiated cells and for generating animals and embryonic stem cells from reprogrammed cells
EP2139447A2 (de) * 2007-03-20 2010-01-06 Harold Brem Gm-csf-kosmezeutikazusammensetzungen und verfahren zu ihrer verwendung
RU2007112288A (ru) * 2007-04-03 2008-10-10 Александр Сергеевич Ботин (RU) Композиция для стимулирования роста и регенерации клеток, а также способ ее получения
CA2629652A1 (en) * 2007-04-24 2008-10-24 Yaojiong Wu Compositions for preventing or treating skin defects and methods of use thereof
EP2152743A2 (de) * 2007-05-23 2010-02-17 Allergan, Inc. Quervernetztes collagen und anwendungen davon
CA2688504A1 (en) 2007-06-18 2008-12-24 Children's Hospital & Research Center At Oakland Method of isolating stem and progenitor cells from placenta
US20100129328A1 (en) * 2007-07-24 2010-05-27 Sing George L Methods for promoting hair growth
KR100848056B1 (ko) * 2007-07-30 2008-07-23 (주)프로스테믹스 줄기세포 배양액을 이용한 멜라닌 합성저해 방법
US8318695B2 (en) * 2007-07-30 2012-11-27 Allergan, Inc. Tunably crosslinked polysaccharide compositions
CN102036688B (zh) * 2007-10-05 2014-07-02 伊西康公司 使用人脐带组织来源的细胞进行肾脏组织的修复和再生
US8697044B2 (en) 2007-10-09 2014-04-15 Allergan, Inc. Crossed-linked hyaluronic acid and collagen and uses thereof
US9975118B2 (en) 2007-11-15 2018-05-22 Seng Enterprises Ltd. Device for the study of living cells
US9145540B1 (en) 2007-11-15 2015-09-29 Seng Enterprises Ltd. Device for the study of living cells
JP5670196B2 (ja) 2007-11-16 2015-02-18 バイセプト セラピューティクス、インク． 紫斑を治療する組成物および方法
US20090143348A1 (en) * 2007-11-30 2009-06-04 Ahmet Tezel Polysaccharide gel compositions and methods for sustained delivery of drugs
US8394784B2 (en) * 2007-11-30 2013-03-12 Allergan, Inc. Polysaccharide gel formulation having multi-stage bioactive agent delivery
US8394782B2 (en) * 2007-11-30 2013-03-12 Allergan, Inc. Polysaccharide gel formulation having increased longevity
US8236538B2 (en) * 2007-12-20 2012-08-07 Advanced Technologies And Regenerative Medicine, Llc Methods for sterilizing materials containing biologically active agents
US9101586B2 (en) * 2007-12-28 2015-08-11 Augustine Bader Topical application and formulation of erythropoietin for skin wound healing
US8535913B2 (en) * 2008-01-30 2013-09-17 Histogen, Inc. Soluble composition for promoting hair growth produced by hypoxic culture of fibroblasts cells
US8530415B2 (en) * 2008-01-30 2013-09-10 Histogen, Inc. Repair and/or regeneration of cells with a composition produced by culturing fibroblast cells under hypoxic conditions
SG10201500237TA (en) * 2008-01-30 2015-04-29 Histogen Inc Extracellular matrix compositions
US8524494B2 (en) 2008-01-30 2013-09-03 Histogen, Inc. Low oxygen tension and BFGF generates a multipotent stem cell from a fibroblast in vitro
US20100166824A1 (en) * 2008-01-30 2010-07-01 Histogen, Inc. Extracellular matrix compositions
EP2257272B1 (de) * 2008-03-31 2013-09-25 Scarcell Therapeutics Verfahren zur kosmetischen behandlung von hautbehandlung bei lichtalterung
US9820747B2 (en) * 2008-04-04 2017-11-21 The Cleveland Clinic Foundation Use of epineural sheath grafts for neural regeneration and protection
WO2009136747A2 (ko) 2008-05-07 2009-11-12 한 쎌 주식회사 줄기세포 배양액을 포함하는 화장료 조성물 및 이의 제조방법
PL2296672T3 (pl) * 2008-06-11 2016-03-31 Fresenius Medical Care Deutschland Gmbh Wzbogacone podłoże progenitorowych komórek wątroby
WO2009157558A1 (ja) 2008-06-26 2009-12-30 科研製薬株式会社 鼓膜または外耳道再生剤
WO2009158634A2 (en) * 2008-06-27 2009-12-30 Zimmer Orthobiologics, Inc. Scaffold coated and/or impregnated with at least one bioactive agent for tissue repair and other medical applications
ES2668398T3 (es) * 2008-07-02 2018-05-17 Allergan, Inc. Composiciones y procedimientos para el relleno y la regeneración de tejidos
US8357795B2 (en) 2008-08-04 2013-01-22 Allergan, Inc. Hyaluronic acid-based gels including lidocaine
US20100058493A1 (en) * 2008-08-29 2010-03-04 Arborgen, Llc Loblolly pine tree named '01NQ0026'
US8497412B2 (en) * 2008-08-29 2013-07-30 Arborgen, Llc Loblolly pine tree named ‘96GE0034’
ES2829971T3 (es) 2008-09-02 2021-06-02 Tautona Group Lp Hilos de ácido hialurónico y/o derivados de los mismos, métodos para fabricar los mismos y usos de los mismos
JP5702723B2 (ja) 2008-09-04 2015-04-15 ザ ジェネラル ホスピタル コーポレイション 声帯および軟組織の増強および修復用ヒドロゲル
WO2010038232A1 (en) * 2008-10-05 2010-04-08 Hymie Friedlander Extract from conditioned medium cultured by regenerative cells
US20100305397A1 (en) * 2008-10-06 2010-12-02 Allergan Medical Sarl Hydraulic-mechanical gastric band
US8431801B2 (en) * 2008-10-08 2013-04-30 Arborgen Inc. Loblolly pine tree named ‘01PM0212’
US20100185049A1 (en) 2008-10-22 2010-07-22 Allergan, Inc. Dome and screw valves for remotely adjustable gastric banding systems
AU2009314506B2 (en) 2008-11-14 2015-07-23 Histogen, Inc. Extracellular matrix compositions for the treatment of cancer
KR20100054711A (ko) * 2008-11-14 2010-05-25 메디포스트(주) 간엽 줄기세포 또는 이의 배양액을 포함하는 신경질환의 예방 또는 치료용 조성물
US20100143313A1 (en) * 2008-12-10 2010-06-10 The General Hospital Corporation Homogeneous differentiation of hepatocyte-like cells from embryonic stem cells
EP2198873A1 (de) * 2008-12-18 2010-06-23 Aposcience AG Pharmazeutisches Präparat, enthaltend den Überstand einer Blutmononuklearzellkultur
AU2009327384B2 (en) 2008-12-19 2014-07-10 DePuy Synthes Products, LLC Treatment of lung and pulmonary diseases and disorders
DK2379087T3 (da) * 2008-12-19 2014-11-10 Depuy Synthes Products Llc Celler, der stammer fra navlestrengsvæv, til behandling af neuropatisk smerte og spasticitet
US10179900B2 (en) * 2008-12-19 2019-01-15 DePuy Synthes Products, Inc. Conditioned media and methods of making a conditioned media
AU2009327383B2 (en) * 2008-12-19 2014-08-28 DePuy Synthes Products, LLC Regeneration and repair of neural tissue following injury
DK2379122T3 (en) * 2008-12-24 2015-08-03 Augustinus Bader FAST PRODUCTION AND USE OF genetically engineered CELLS AND STRUCTURES AS INDIVIDUAL IMPLANTS
US8771677B2 (en) * 2008-12-29 2014-07-08 Vladimir B Serikov Colony-forming unit cell of human chorion and method to obtain and use thereof
WO2010093848A1 (en) * 2009-02-13 2010-08-19 Invitrx, Inc. Skin cream
KR101422690B1 (ko) * 2009-02-27 2014-07-23 (주)차바이오앤디오스텍 배아줄기세포 유래 혈관형성전구세포의 배양 분비물을 포함하는 피부재생용 조성물 및 이의 용도
US8574902B2 (en) 2009-03-05 2013-11-05 Macrocure Ltd. Activated leukocyte composition and uses for wound healing
KR101078419B1 (ko) * 2009-03-20 2011-10-31 주식회사 스템메디언스 양수 내 태아 유래 중간엽줄기세포를 이용한 피부 상태개선용 조성물
EP2411504B1 (de) 2009-03-26 2017-05-10 DePuy Synthes Products, Inc. Humane nabelschnur gewebezellen in der alzheimer therapie
FI20095355A0 (fi) * 2009-04-01 2009-04-01 Helsingin Yliopisto Regeneroituva aktiivinen matriisi ja sen käytöt
KR101422453B1 (ko) * 2009-04-16 2014-07-28 (주)차바이오앤디오스텍 제대혈 줄기세포 유래 혈관전구세포 배양액 또는 배양 분비물을 이용한 피부재생용 조성물 및 이의 용도
US8390326B2 (en) * 2009-05-05 2013-03-05 William Marsh Rice University Method for fabrication of a semiconductor element and structure thereof
CA2767600C (en) * 2009-07-10 2022-05-31 Histogen, Inc. Conditioned medium and extracellular matrix compositions from cells cultured under hypoxic conditions
EP2456862A4 (de) * 2009-07-20 2013-02-27 Janssen Biotech Inc Differenzierung menschlicher embryonischer stammzellen
US20120171172A1 (en) * 2009-09-04 2012-07-05 Maria Siemionow Methods Of Engineering Neural Tissue
GB0916370D0 (en) * 2009-09-18 2009-10-28 Avecia Biolog Ltd Compositions
US8790710B1 (en) 2009-10-02 2014-07-29 Novo Solutions, MD, L.L.C. Topical composition comprising umbilical cord blood serum
WO2011072119A2 (en) * 2009-12-10 2011-06-16 The Research Foundation Of State University Of Newyork Stem-cell material and method of use
US20110172180A1 (en) 2010-01-13 2011-07-14 Allergan Industrie. Sas Heat stable hyaluronic acid compositions for dermatological use
US20110171286A1 (en) * 2010-01-13 2011-07-14 Allergan, Inc. Hyaluronic acid compositions for dermatological use
US9114188B2 (en) 2010-01-13 2015-08-25 Allergan, Industrie, S.A.S. Stable hydrogel compositions including additives
US20110171311A1 (en) * 2010-01-13 2011-07-14 Allergan Industrie, Sas Stable hydrogel compositions including additives
BR112012017463A2 (pt) * 2010-01-14 2015-09-15 Organogenesis Inc constructos de tecido de bioengenharia e métodos para sua produção e uso
MD191Z5 (ro) * 2010-01-21 2010-11-30 Государственный Медицинский И Фармацевтический Университет "Nicolae Testemitanu" Республики Молдова Mediu nutritiv pentru cultivarea celulelor de origine animală
US20120315259A1 (en) * 2010-02-18 2012-12-13 Hyman Friedlander Method and composition for skin care comprising cord blood serum or plasma or components thereof
KR20110097064A (ko) * 2010-02-24 2011-08-31 (주) 아크스템 무혈청 줄기 세포 배양 조성물, 이를 함유한 조직 재생용 조성물 및 이를 이용한 조직 재생 방법
US8840541B2 (en) 2010-02-25 2014-09-23 Apollo Endosurgery, Inc. Pressure sensing gastric banding system
US9198568B2 (en) 2010-03-04 2015-12-01 The General Hospital Corporation Methods and systems of matching voice deficits with a tunable mucosal implant to restore and enhance individualized human sound and voice production
FR2957254B1 (fr) 2010-03-12 2016-10-14 Allergan Ind Sas Compositions fluides pour ameliorer les etats de la peau
PL2550027T5 (pl) 2010-03-22 2019-07-31 Allergan, Inc. Polisacharydowe i białkowo-polisacharydowe usieciowane hydrożele do powiększania tkanek miękkich
US8911963B2 (en) * 2010-04-05 2014-12-16 Medstar Health Research Institute, Inc. Conditioned medium obtained from stem cells and its use in therapy
US9028394B2 (en) 2010-04-29 2015-05-12 Apollo Endosurgery, Inc. Self-adjusting mechanical gastric band
US20110270024A1 (en) 2010-04-29 2011-11-03 Allergan, Inc. Self-adjusting gastric band having various compliant components
US9044298B2 (en) 2010-04-29 2015-06-02 Apollo Endosurgery, Inc. Self-adjusting gastric band
US8877494B2 (en) * 2010-06-04 2014-11-04 Ahmed H. Al-Qahtani Human corneal epithelial cell line PTA-120527
US20110300097A1 (en) * 2010-06-04 2011-12-08 Al-Qahtani Ahmed H Method And Composition For The Treatment Of Moderate To Severe Keratoconjunctivitis Sicca
US8517915B2 (en) 2010-06-10 2013-08-27 Allergan, Inc. Remotely adjustable gastric banding system
CN101879329A (zh) * 2010-06-21 2010-11-10 蒋明军 含基底膜的人工皮肤构建方法及人工皮肤
US8697057B2 (en) 2010-08-19 2014-04-15 Allergan, Inc. Compositions and soft tissue replacement methods
US8889123B2 (en) 2010-08-19 2014-11-18 Allergan, Inc. Compositions and soft tissue replacement methods
US8883139B2 (en) 2010-08-19 2014-11-11 Allergan Inc. Compositions and soft tissue replacement methods
US9005605B2 (en) 2010-08-19 2015-04-14 Allergan, Inc. Compositions and soft tissue replacement methods
JP2013536252A (ja) 2010-08-27 2013-09-19 ファイブロセル テクノロジーズ， インコーポレイテッド 局所皮膚製剤
US20120059216A1 (en) 2010-09-07 2012-03-08 Allergan, Inc. Remotely adjustable gastric banding system
US9168287B2 (en) * 2010-09-09 2015-10-27 Macrocure, Ltd. Activated leukocyte conditioned supernatant and uses for wound healing
US9725689B2 (en) 2010-10-08 2017-08-08 Terumo Bct, Inc. Configurable methods and systems of growing and harvesting cells in a hollow fiber bioreactor system
US8765121B2 (en) 2010-10-14 2014-07-01 Fibrocell Technologies, Inc. Treatment of vocal cords with autologous dermal fibroblast formulation
KR20140018371A (ko) 2010-11-12 2014-02-12 알러간, 인코포레이티드 물질대사된 조건화 성장 배지 및 이용 방법
RU2455354C1 (ru) * 2010-12-29 2012-07-10 Антонина Ивановна Колесникова Композиция для регенерации клеток кожи и слизистых оболочек
ES2647471T3 (es) 2011-01-18 2017-12-21 Noveome Biotherapeutics, Inc. Dispositivo y procedimiento para la curación de heridas
JP5784754B2 (ja) 2011-02-02 2015-09-24 メディポスト・カンパニー・リミテッドＭｅｄｉｐｏｓｔ Ｃｏ．， Ｌｔｄ． 神経疾患の予防または処置のためのｉｃａｍ−１の使用
US9119974B2 (en) * 2011-03-04 2015-09-01 Ahmed H. Al-Qahtani Skin cream
EP2680865B1 (de) * 2011-03-04 2017-04-26 Al-Qahtani, Ahmed H. Hautcreme
KR101349183B1 (ko) * 2011-03-14 2014-01-08 서울대학교산학협력단 3차원 세포배양으로 수득한 조건 배지를 유효성분으로 포함하는 허혈성 질환 치료용 약학적 조성물
US9446075B2 (en) 2011-05-06 2016-09-20 Bioregenerative Sciences Compositions derived from stem cell released molecules and methods for formulation thereof
US9408797B2 (en) 2011-06-03 2016-08-09 Allergan, Inc. Dermal filler compositions for fine line treatment
US9393263B2 (en) 2011-06-03 2016-07-19 Allergan, Inc. Dermal filler compositions including antioxidants
US20130096081A1 (en) 2011-06-03 2013-04-18 Allergan, Inc. Dermal filler compositions
CN107412002A (zh) 2011-06-03 2017-12-01 阿勒根公司 包括抗氧化剂的皮肤填充剂组合物
CN102266586B (zh) * 2011-06-28 2013-12-04 江苏省人民医院 白癜风黑素细胞移植涂布载体系统的制备方法
US20130244943A1 (en) 2011-09-06 2013-09-19 Allergan, Inc. Hyaluronic acid-collagen matrices for dermal filling and volumizing applications
US9662422B2 (en) 2011-09-06 2017-05-30 Allergan, Inc. Crosslinked hyaluronic acid-collagen gels for improving tissue graft viability and soft tissue augmentation
US8876694B2 (en) 2011-12-07 2014-11-04 Apollo Endosurgery, Inc. Tube connector with a guiding tip
US8961394B2 (en) 2011-12-20 2015-02-24 Apollo Endosurgery, Inc. Self-sealing fluid joint for use with a gastric band
US9611513B2 (en) 2011-12-23 2017-04-04 DePuy Synthes Products, Inc. Detection of human umbilical cord tissue derived cells
US9782440B2 (en) * 2012-02-16 2017-10-10 The Cleveland Clinic Foundation Methods for treating genitourinary disorders
KR102126331B1 (ko) * 2012-02-23 2020-06-25 주식회사 탑셀바이오 컨디션드 배지 분말의 제조방법
CA2866563A1 (en) 2012-03-07 2013-09-12 Fibrocell Technologies, Inc. Topical dermal formulations and methods of personalized treatment of skin
US20130244948A1 (en) * 2012-03-15 2013-09-19 Scharp Technologies, Inc. Compositions of cells, media, and methods thereof
CN102600057B (zh) * 2012-03-16 2013-05-01 广州赛莱拉生物科技有限公司 人胎盘干细胞提取物冻干粉及其制备方法与应用
US11744856B1 (en) * 2012-04-11 2023-09-05 Medicell Technologies, Llc Compositions and methods to improve skin quality and appearance, cure skin and tissue damage, and use in therapy
US9445980B2 (en) * 2012-04-18 2016-09-20 Mark Laney Methods for stimulating hair growth
RU2530614C2 (ru) * 2012-05-04 2014-10-10 Владимир Петрович Швецов Биологический активный комплекс для органогенеза и продукт секреции клеток, содержащихся в этом комплексе
US9545370B2 (en) 2012-05-08 2017-01-17 BioRegenerative Sciences, Inc. Bioactive compositions and methods for their preparation and use
US9354237B2 (en) 2012-05-18 2016-05-31 Purdue Research Foundation Methods for isolating proteins
EP2682168A1 (de) 2012-07-02 2014-01-08 Millipore Corporation Reinigung biologischer Moleküle
RU2665793C2 (ru) * 2012-07-24 2018-09-04 Ниссан Кемикал Индастриз, Лтд. Композиция культуральной среды и способ культивирования клетки или ткани с использованием указанной композиции
RU2512681C2 (ru) * 2012-08-22 2014-04-10 Антонина Ивановна Колесникова Способ лечения длительно незаживающей раны и/или раневой полости
US9220817B2 (en) * 2013-03-13 2015-12-29 Stemnion, Inc. Medical device
ES2778098T3 (es) * 2013-03-13 2020-08-07 Univ Miami Método de aislamiento y purificación de microvesículas de sobrenadantes de cultivo celular y fluidos biológicos
WO2014153294A1 (en) * 2013-03-17 2014-09-25 The Regents Of The University Of California Method to expand and transduce cultured human small and large intestinal stem cells
CN105246494B (zh) * 2013-04-19 2020-02-07 高丽大学校产学协力团 刺激毛发生长或防止毛发脱落的包括神经干细胞的提取物的组合物及其制造方法
EP2801613A1 (de) 2013-05-08 2014-11-12 Ecole Polytechnique Fédérale de Lausanne (EPFL) Anordnungen abgetrennter Zellkultur-Mikroumgebungen, Verfahren zur Herstellung solcher Anordnungen und Verwendungen davon
RU2526814C1 (ru) * 2013-06-17 2014-08-27 Государственное бюджетное учреждение здравоохранения города Москвы Научно-исследовательский институт скорой помощи имени Н.В. Склифосовского Департамента здравоохранения г. Москвы Способ восстановления кожного покрова у пациентов с обширными ранами с дефектом мягких тканей (варианты)
CA2930556A1 (en) * 2013-11-14 2015-05-21 Dermarche Labs, Llc Fibroblast mixtures and methods of making and using the same
CN105992816B (zh) 2013-11-16 2018-04-17 泰尔茂比司特公司 生物反应器中的细胞扩增
CN103736080B (zh) * 2013-11-29 2016-06-22 焦阳 用于伤口愈合的制剂、制备方法及其用途
GB201322869D0 (en) 2013-12-23 2014-02-12 Ucl Business Plc Therapeutic agents and delivery with microspheres
WO2015103524A1 (en) * 2014-01-05 2015-07-09 David Muller Systems and methods for producing and applying tissue-related structures
US9907745B2 (en) 2014-01-15 2018-03-06 Serucell Corporation Cosmetic compositions and method of making the same
US9974813B1 (en) 2014-01-15 2018-05-22 Serucell Corporation Therapeutic serum obtained from co-cultured cells
US10533191B2 (en) 2014-01-15 2020-01-14 Serucell Corporation Therapeutic serum obtained from co-cultured cells
US10047344B2 (en) * 2014-02-18 2018-08-14 National University Of Singapore Biophysically sorted osteoprogenitors from culture expanded bone marrow derived mesenchymal stromal cells (MSCs)
TWI558421B (zh) * 2014-03-06 2016-11-21 芯芮生技開發股份有限公司 幹細胞條件培養基用於製備抑制氧化作用達到皮膚抗老化之組成物的用途
KR101623189B1 (ko) * 2014-03-14 2016-05-20 (주)세포바이오 중간엽 줄기세포 유래 단백질을 함유하는 조직 재생용 조성물
EP3122866B1 (de) 2014-03-25 2019-11-20 Terumo BCT, Inc. Passives ersetzen von medien
US9284528B2 (en) 2014-04-18 2016-03-15 Growgene Biotech Inc. Use of stem cell conditioned medium to inhibit oxidation for anti-aging skin
US20150328263A1 (en) * 2014-05-14 2015-11-19 University Of Maryland, Baltimore Cardiac stem cells for cardiac repair
WO2016006788A1 (ko) * 2014-07-07 2016-01-14 메디포스트(주) 작은 크기 줄기세포의 발모 촉진능 및 이의 용도
WO2016044555A1 (en) 2014-09-17 2016-03-24 Massachusetts Institute Of Technology System and method for inertial focusing microfiltration for intra-operative blood salvage autotransfusion
EP3198006B1 (de) 2014-09-26 2021-03-24 Terumo BCT, Inc. Geplante fütterung
RU2574017C1 (ru) * 2014-09-30 2016-01-27 Федеральное государственное бюджетное образовательное учреждение высшего образования "Московский государственный университет имени М.В. Ломоносова" (МГУ) Средство для лечения ожогов и ран на основе цитокинов и факторов роста, секретируемых мезенхимными клетками человека, способ получения средства и способ лечения ожогов и ран
US10722444B2 (en) 2014-09-30 2020-07-28 Allergan Industrie, Sas Stable hydrogel compositions including additives
CN107208025A (zh) 2014-11-25 2017-09-26 康宁股份有限公司 延续细胞培养基的材料和方法
US10842735B2 (en) 2014-11-28 2020-11-24 Dong Hyun AHN Hair growth-promoting composition
KR101570004B1 (ko) * 2014-11-28 2015-11-17 안동현 발모촉진용 조성물
RU2644650C2 (ru) 2014-12-01 2018-02-13 Общество с ограниченной ответственностью "Т-Хелпер Клеточные Технологии" Материал стволовых клеток и способ его получения
WO2016128783A1 (en) 2015-02-09 2016-08-18 Allergan Industrie Sas Compositions and methods for improving skin appearance
RU2745413C2 (ru) * 2015-06-04 2021-03-24 Фондационе Ирккс Ка' Гранда - Оспедале Маджоре Поликлинико Система из множества пакетов и способ приготовления компонентов крови
RU2587755C1 (ru) * 2015-06-10 2016-06-20 Федеральное государственное бюджетное учреждение "Государственный научный центр Российской Федерации - Федеральный Медицинский биофизический центр имени А.И. Бурназяна Федерального Медико-биологического агентства" (ФГБУ ГНЦ ФМБЦ им. А.И. Бурназяна ФМБА России) Способ получения действующего вещества из пантов марала
BE1023155B1 (nl) 2015-06-30 2016-12-02 Guido Wouters Samenstelling voor wondheling
WO2017004592A1 (en) 2015-07-02 2017-01-05 Terumo Bct, Inc. Cell growth with mechanical stimuli
CN108289927A (zh) * 2015-11-30 2018-07-17 德玛福斯控股有限责任公司 含有蛋白的外用皮肤组合物和使用方法
US11254915B2 (en) 2015-12-11 2022-02-22 Lei Guo Method for separating and culturing mesenchymal stem cells from Wharton's jelly tissue of umbilical cord
WO2017096616A1 (zh) * 2015-12-11 2017-06-15 郭镭 一种无血清培养基及其制备方法和用途
RU2620167C1 (ru) * 2015-12-21 2017-05-23 Федеральное государственное бюджетное образовательное учреждение высшего образования "Московский государственный университет имени М.В. Ломоносова" (МГУ) Способ получения средства для стимуляции регенерации на основе продуктов секреции мультипотентных мезенхимных стромальных клеток человека
CN108699512A (zh) * 2016-02-22 2018-10-23 国立大学法人大阪大学 立体细胞组织的制造方法
US11071706B2 (en) 2016-04-01 2021-07-27 Biocoz Global Korea Corp. Cosmetic composition containing, as active ingredient, albumin, hyaluronic acid or collagen in cell culture medium
US10894947B1 (en) * 2016-04-29 2021-01-19 Hope Biosciences, Llc Method for generating protein rich conditioned medium
US11111480B2 (en) 2016-04-29 2021-09-07 Hope Biosctences, Llc Culture media for multipotent stem cells
RU2620342C1 (ru) * 2016-05-11 2017-05-24 Общество С Ограниченной Ответственностью "Генная И Клеточная Терапия" (Ооо "Генная И Клеточная Терапия") Косметическое средство на основе продуктов секреции мезенхимных стволовых/стромальных клеток жировой ткани человека и способ его получения
WO2017197262A1 (en) * 2016-05-12 2017-11-16 Insitu Biologics, Llc Hydrogel-based biological delivery vehicle
RU2708329C2 (ru) 2016-05-31 2019-12-05 Общество с ограниченной ответственностью "Т-Хелпер Клеточные Технологии" Материал стволовых клеток, композиции и способы применения
US11104874B2 (en) 2016-06-07 2021-08-31 Terumo Bct, Inc. Coating a bioreactor
US11685883B2 (en) 2016-06-07 2023-06-27 Terumo Bct, Inc. Methods and systems for coating a cell growth surface
CN106754669B (zh) * 2016-11-23 2020-04-17 河海大学常州校区 基于反应-扩散模型的多细胞结构的制备方法及制备系统
RU2644278C1 (ru) * 2016-12-21 2018-02-08 Федеральное государственное автономное учреждение "Национальный медицинский исследовательский центр нейрохирургии имени академика Н.Н.Бурденко" Министерства здравоохранения Российской Федерации (ФГАУ "НМИЦ нейрохирургии им. акад. Н.Н.Бурденко" Минздрава России Способ микрохирургической реконструкции спинного мозга на животной модели с использованием биодеградируемого гидрогеля на основе поливинилового спирта
AR111512A1 (es) * 2017-02-23 2019-07-24 Japan Vam & Poval Co Ltd Dispositivo de integración celular o tisular
US11702634B2 (en) 2017-03-31 2023-07-18 Terumo Bct, Inc. Expanding cells in a bioreactor
KR102544417B1 (ko) * 2017-03-31 2023-06-16 셀룸 바이오메디컬, 인크. 생체 적합성의 조건화된 세포 배지 조성물 및 그의 용도
US11624046B2 (en) 2017-03-31 2023-04-11 Terumo Bct, Inc. Cell expansion
JP6438527B2 (ja) * 2017-06-01 2018-12-12 Ｎｃメディカルリサーチ株式会社 神経変性の治療のための細胞療法
CN107261213A (zh) * 2017-06-13 2017-10-20 北京恒峰铭成生物科技有限公司 一种活性水凝胶及其制备方法和在手术创伤修复中的应用
US11718829B2 (en) 2017-07-28 2023-08-08 Breakthrough Tech Llc Methods and compositions for manufacturing extracellular matrix
US11696929B2 (en) 2017-09-20 2023-07-11 The Regents Of The University Of California Methods and systems for conserving highly expanded cells
WO2019140267A1 (en) * 2018-01-12 2019-07-18 Histogen, Inc. Nutraceutical products from cell conditioned medium from cells cultured under hypoxic conditions
CN108486045A (zh) * 2018-01-23 2018-09-04 广东颜值科技有限公司 一种人成纤维细胞的培养组合物
FR3078541B1 (fr) * 2018-03-05 2022-07-08 Genoskin Modele d’injection sous-cutanee ex vivo
RU2716159C2 (ru) * 2018-03-06 2020-03-06 Андрей Александрович Темнов Композиция для профилактического или терапевтического лечения состояний, связанных с изменением количества волос
AU2019276713A1 (en) * 2018-05-30 2021-01-21 Direct Biologics Llc A growth factor and extracellular vesicle frozen or powdered additive comprising a mesenchymal stem cell (MSC) preparation and methods of use
US11369718B1 (en) * 2018-08-24 2022-06-28 Ariasa LLC Method and use of cryopreserved mesenchymal stem cells via liquid suspension from the amniotic sac for rejuvenation of the midface
WO2020130800A1 (en) * 2018-12-21 2020-06-25 Cytonex Sdn. Bhd. Stem cell conditioned media
US10881693B2 (en) 2019-04-09 2021-01-05 Combangio, Inc. Processes for making and using a mesenchymal stem cell derived secretome
US20220211768A1 (en) * 2019-05-02 2022-07-07 Histogen, Inc. Conditioned medium and methods of use thereof
US11065188B2 (en) 2019-05-29 2021-07-20 Av Laboratories Llc Applications and formulations of optimized, modified human embryonic fertility culture media with biguanides and/or functional equivalents
AU2020327956A1 (en) * 2019-08-09 2022-02-03 Axolotl Biologix, Inc. Compositions derived from human amnion cells and related methods
WO2021055579A1 (en) * 2019-09-19 2021-03-25 Life Technologies Corporation Cell culture media tablets and methods of manufacture
CN110607279B (zh) * 2019-10-18 2023-09-19 深圳优圣康医学检验实验室 一种原代肿瘤细胞的3d培养体系及其培养方法和应用
CN112980796A (zh) * 2019-12-17 2021-06-18 东莞市东阳光生物药研发有限公司 用于降低cho细胞中表达重组蛋白的氧化的液体培养基
CN111658672A (zh) * 2020-06-20 2020-09-15 河南和泽干细胞基因工程有限公司 一种人胎盘干细胞提取物冻干粉及其制备方法
US20230000954A1 (en) 2021-07-02 2023-01-05 Combangio, Inc. Processes for making and using a cellular fibronectin composition
US20230043556A1 (en) 2021-07-30 2023-02-09 L'oreal Compositions comprising extracellular vesicles, secreted biomolecules, and/or conditioned media, and methods of producing and using the same
FR3126617A1 (fr) 2021-09-06 2023-03-10 L'oreal compositions comprenant des vésicules extracellulaires, des biomolécules sécrétées et/ou des milieux conditionnés, et procédés pour les produire
CN115074322B (zh) * 2022-07-01 2024-01-26 江南大学 一种高效获取多种生物活性功能因子的鼻黏膜外胚层间充质干细胞三维培养方法
BR102022016233A2 (pt) * 2022-08-16 2024-02-27 Omics Biotecnologia Animal Ltda Concentrado de proteínas e peptídeos derivados de células estromais mesenquimais, método de obtenção e uso de concentrado
CN115518198B (zh) * 2022-10-11 2024-01-16 青岛大学 一种负载双向梯度ecm涂层的血管修复支架及其制备方法

Family Cites Families (107)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2004A (en) * 1841-03-12 Improvement in the manner of constructing and propelling steam-vessels
US2007A (en) * 1841-03-16 Improvement in the mode of harvesting grain
US564381A (en) * 1896-07-21 Prune or fruit dipper
US4458678A (en) 1981-10-26 1984-07-10 Massachusetts Institute Of Technology Cell-seeding procedures involving fibrous lattices
US4485096A (en) 1982-02-26 1984-11-27 Massachusetts Institute Of Technology Tissue-equivalent and method for preparation thereof
ES8503941A1 (es) * 1982-10-27 1985-04-16 Crinos Industria Farmaco Procedimiento de obtencion de composiciones para promover el trofismo de la piel y de foliculos piliferosos relacionados
US4911720A (en) 1983-03-10 1990-03-27 Collier John P Particular surface replacement prosthesis
JPS6133124A (ja) * 1983-11-04 1986-02-17 ラルフ　シルヴア−マン 異性々疾患を治療するための培養間葉細胞から抽出した巨大分子
US4757017A (en) * 1984-09-14 1988-07-12 Mcw Research Foundation, Inc. In vitro cell culture system
US4861714A (en) * 1985-04-04 1989-08-29 Verax Corporation Weighted collagen microsponge for immobilizing bioactive material
US4806523A (en) * 1985-08-06 1989-02-21 Collagen Corporation Method of treating inflammation
FR2586703B1 (fr) 1985-09-02 1989-12-01 Merieux Inst Procede d'extraction de collagenes placentaires, collagenes obtenus notamment sous forme de gels ou de solutions et leurs applications
CA1282725C (en) * 1986-04-18 1991-04-09 Brian A. Naughton Process for replicating bone marrow in vitro and using the same
US4963489A (en) 1987-04-14 1990-10-16 Marrow-Tech, Inc. Three-dimensional cell and tissue culture system
US5902741A (en) * 1986-04-18 1999-05-11 Advanced Tissue Sciences, Inc. Three-dimensional cartilage cultures
US5266480A (en) 1986-04-18 1993-11-30 Advanced Tissue Sciences, Inc. Three-dimensional skin culture system
US5863531A (en) * 1986-04-18 1999-01-26 Advanced Tissue Sciences, Inc. In vitro preparation of tubular tissue structures by stromal cell culture on a three-dimensional framework
US5460939A (en) * 1986-04-18 1995-10-24 Advanced Tissue Sciences, Inc. Temporary living skin replacement
US5032508A (en) 1988-09-08 1991-07-16 Marrow-Tech, Inc. Three-dimensional cell and tissue culture system
US5565347A (en) * 1986-06-10 1996-10-15 Calgene, Inc. Transformation and foreign gene expression with plant species
JPH0618781B2 (ja) * 1986-10-18 1994-03-16 中外製薬株式会社 感染症治療剤
US5804178A (en) 1986-11-20 1998-09-08 Massachusetts Institute Of Technology Implantation of cell-matrix structure adjacent mesentery, omentum or peritoneum tissue
US5736372A (en) 1986-11-20 1998-04-07 Massachusetts Institute Of Technology Biodegradable synthetic polymeric fibrous matrix containing chondrocyte for in vivo production of a cartilaginous structure
CA1340581C (en) 1986-11-20 1999-06-08 Joseph P. Vacanti Chimeric neomorphogenesis of organs by controlled cellular implantation using artificial matrices
US4885163A (en) * 1987-02-24 1989-12-05 Eli Lilly And Company Topical use of IGF-II for wound healing
KR0131822B1 (ko) * 1988-05-23 1998-04-11 죤 에프. 튜은트 바이오 반응기 장치
GEP20022681B (en) * 1989-01-31 2002-04-25 Aaronson Us Stuart A Protein KFG, Antibodies, Pharmaceutical Composition, Their Use, recombinant DNA, Cell, Method for Discoveries and Production of Proteins, Method for Stimulation of Epithelial Cells Growth
US5693625A (en) * 1989-03-09 1997-12-02 Therapeutiques Substitutives Method of regenerating cells and tissues using functionalized dextrans
US5091173A (en) * 1989-06-29 1992-02-25 The University Of Dundee Hair growth composition
US5830709A (en) * 1989-10-27 1998-11-03 Benson; Roger E. Detection method for homologous portions of a class of substances
US5292655A (en) * 1990-01-29 1994-03-08 Wille Jr John J Method for the formation of a histologically-complete skin substitute
ATE161408T1 (de) 1990-04-24 1998-01-15 Mark Eisenberg Zusammengesetztes äquivalent der lebenden haut
CA2051796A1 (en) 1990-09-21 1992-03-22 Marvin L. Bayne Vascular endothelial cell growth factor ii
US5478560A (en) * 1990-10-19 1995-12-26 Shiseido Company Ltd. External dermatological composition
US5229493A (en) 1990-10-26 1993-07-20 Children's Medical Center Corporation Smooth muscle mitogen
US7196054B1 (en) 1990-11-27 2007-03-27 The American National Red Cross Methods for treating wound tissue and forming a supplemented fibrin matrix
US5763367A (en) * 1991-03-28 1998-06-09 Bottom Line Industries, Inc. Well fluid additive, well fluid made therefrom, method of treating a well fluid, method of circulating a well fluid
CA2089653A1 (en) 1991-06-17 1992-12-18 Dennis M. Disorbo Media concentrate technology
WO1993004164A1 (en) * 1991-08-26 1993-03-04 THE STATE OF OREGON acting by and through THE STATE OF BOARD OF HIGHER EDUCATION on behalf of THE OREGON HEALTH SCIENCES UNIVERSITY Keratinocyte-derived conditioned medium as a source of growth factors
US6324404B1 (en) * 1991-12-26 2001-11-27 Sycord Limited Partnership Cellular telephone system that uses position of a mobile unit to make call management decisions
US5235633A (en) * 1991-12-26 1993-08-10 Everett Dennison Cellular telephone system that uses position of a mobile unit to make call management decisions
ES2153378T3 (es) 1992-02-28 2001-03-01 Univ Texas Hidrogeles biodegradables fotopolimerizables como materiales de contacto de tejidos y portadores de descarga controlada.
US5255307A (en) * 1992-05-07 1993-10-19 Sony Electronics Inc. Status indicator control for cellular mobile telephone system
US5618544A (en) 1992-08-12 1997-04-08 Bays-Brown Dermatologics, Inc. Method of decreasing cutaneous senescence
US5774193A (en) 1992-10-05 1998-06-30 Vaughan; Thomas J. Digital television (HDTV) and analog television (NTSC) broadcast systems combined for simultaneous broadcast
JPH06133124A (ja) 1992-10-20 1994-05-13 Fuji Xerox Co Ltd 画像記録装置
US5478739A (en) 1992-10-23 1995-12-26 Advanced Tissue Sciences, Inc. Three-dimensional stromal cell and tissue culture system
RU2054924C1 (ru) 1992-12-30 1996-02-27 Акционерное общество "Биотехнология" Препарат для лечения инфицированных вялозаживающих ран и язв
AU696691C (en) 1993-03-12 2003-09-18 American National Red Cross, The Supplemented and unsupplemented tissue sealants, methods of their production and use
US5407912A (en) * 1993-04-19 1995-04-18 Akzo, N.V. Method of treating bladder cancer with a keyhole limpet hemocyanin composition with enhanced anti-tumor activity
US5709854A (en) 1993-04-30 1998-01-20 Massachusetts Institute Of Technology Tissue formation by injecting a cell-polymeric solution that gels in vivo
RU2063743C1 (ru) 1993-06-01 1996-07-20 Акционерное общество закрытого типа "Химбио" Крем для питания, защиты и предотвращения старения кожи
CA2134729C (en) * 1993-11-01 1999-09-07 Thomas E. Buss Location dependent information receiving device and method
US6084724A (en) 1993-12-30 2000-07-04 Eastman Kodak Company Glass coated cemented plastic doublets and method for making
US5935849A (en) * 1994-07-20 1999-08-10 Cytotherapeutics, Inc. Methods and compositions of growth control for cells encapsulated within bioartificial organs
US5516532A (en) 1994-08-05 1996-05-14 Children's Medical Center Corporation Injectable non-immunogenic cartilage and bone preparation
FI96558C (fi) * 1994-09-27 1996-07-10 Nokia Telecommunications Oy Menetelmä datasiirtoa varten TDMA-matkaviestinjärjestelmässä sekä menetelmän toteuttava matkaviestinjärjestelmä
EP0797874A1 (de) * 1994-12-12 1997-10-01 Ericsson Inc. Kanalzuteilung mit rücksicht auf diversität in einer mobilen kommunikationsanordnung
WO1996018726A1 (en) 1994-12-15 1996-06-20 THE UNITED STATES GOVERNMENT, represented by THE SECRETARY OF THE NAVY Compositions and methods for stimulating hematopoietic cell expansion
US5900245A (en) 1996-03-22 1999-05-04 Focal, Inc. Compliant tissue sealants
US5830708A (en) 1995-06-06 1998-11-03 Advanced Tissue Sciences, Inc. Methods for production of a naturally secreted extracellular matrix
CA2223889A1 (en) 1995-06-07 1996-12-19 The American National Red Cross Supplemented and unsupplemented tissue sealants, methods of their production and use
US5843766A (en) 1995-06-07 1998-12-01 Advanced Tissue Sciences, Inc. Apparatus for the growth and packaging of three dimensional tissue cultures
US5654381A (en) 1995-06-16 1997-08-05 Massachusetts Institute Of Technology Functionalized polyester graft copolymers
GB2304497A (en) * 1995-08-19 1997-03-19 Northern Telecom Ltd Cellular communications system with provision of services to visiting mobiles
JPH11512435A (ja) * 1995-09-12 1999-10-26 ジェネンテック インコーポレーテッド 嚢胞性繊維症の治療
FR2739621B1 (fr) 1995-10-05 1997-12-05 Centre Nat Rech Scient Peptides utilisables comme vecteurs pour l'adressage intracellulaire de molecules actives
US5965125A (en) * 1995-10-25 1999-10-12 Transkaryotic Therapies, Inc. Hybrid matrix implants and explants
JP2679694B2 (ja) 1995-11-08 1997-11-19 コクヨ株式会社 ホルダー
US5787348A (en) * 1995-12-06 1998-07-28 Motorola, Inc. Method of measuring speed of a mobile unit and a receiver for use in a wireless communication system
US5888551A (en) 1995-12-11 1999-03-30 University Of Miami Hair growth stimulating composition
US6048964A (en) * 1995-12-12 2000-04-11 Stryker Corporation Compositions and therapeutic methods using morphogenic proteins and stimulatory factors
US5708854A (en) * 1996-01-24 1998-01-13 Eastman Kodak Company One-time-use camera has driver for closing film cassette which is removed with closed cassette to disable camera after completed use
US5826014A (en) * 1996-02-06 1998-10-20 Network Engineering Software Firewall system for protecting network elements connected to a public network
US5770448A (en) * 1996-03-29 1998-06-23 Northwestern University Human epithelial cell matrix and uses therefor
US5763267A (en) * 1996-04-16 1998-06-09 Advanced Tissue Sciences Apparatus for the large scale growth and packaging of cell suspensions and three-dimensional tissue cultures
US6132759A (en) * 1996-05-03 2000-10-17 Innogenetics N.V. Medicaments containing gelatin cross-linked with oxidized polysaccharides
US5667791A (en) * 1996-05-31 1997-09-16 Thione International, Inc. X-ray induced skin damage protective composition
US5857201A (en) * 1996-06-18 1999-01-05 Wright Strategies, Inc. Enterprise connectivity to handheld devices
ATE434034T1 (de) 1996-08-23 2009-07-15 Vegenics Ltd Rekombinanter vasculärer endothelzellen wachstumsfaktor d (vegf-d)
US5914668A (en) * 1996-08-30 1999-06-22 Lucent Technologies Inc. Wireless terminal controlled mobility operational parameters
DE69728415T2 (de) 1996-10-15 2004-08-12 Amgen Inc., Thousand Oaks Produkte des keratinocyten-wachstumsfaktors 2 (kgf-2)
WO1998021312A1 (en) 1996-11-08 1998-05-22 Rpms Technology Limited Human hepatocytes in three-dimensional support systems
US6044273A (en) * 1996-12-10 2000-03-28 Northern Telecom Limited Method and apparatus for designing a communication system by modeling spatial and temporal behavior of user mobility demand
US5814328A (en) * 1997-01-13 1998-09-29 Gunasekaran; Subramanian Preparation of collagen using papain and a reducing agent
US5970403A (en) * 1997-03-04 1999-10-19 Ericsson Inc. Load based charging within a mobile telecommunications network
RU2142783C1 (ru) 1997-03-06 1999-12-20 Децина Анатолий Николаевич Регенерирующее косметическое средство для ухода за кожей
US6044261A (en) * 1997-03-19 2000-03-28 Ericsson, Inc. Multiple home zone areas within a mobile telecommunications network
US6224893B1 (en) 1997-04-11 2001-05-01 Massachusetts Institute Of Technology Semi-interpenetrating or interpenetrating polymer networks for drug delivery and tissue engineering
IL121041A0 (en) * 1997-06-09 1997-11-20 Yeda Res & Dev Immunogenic compositions for induction of anti-tumor immunity
US6091956A (en) * 1997-06-12 2000-07-18 Hollenberg; Dennis D. Situation information system
US6070184A (en) * 1997-08-28 2000-05-30 International Business Machines Corporation Server-side asynchronous form management
GB9718609D0 (en) 1997-09-02 1997-11-05 Imp College Innovations Ltd Fusion protein
US6075797A (en) * 1997-10-17 2000-06-13 3Com Corporation Method and system for detecting mobility of a wireless-capable modem to minimize data transfer rate renegotiations
RU2141814C1 (ru) 1997-11-28 1999-11-27 Беляков Юрий Иванович Шампунь на основе молочной сыворотки
US6291240B1 (en) * 1998-01-29 2001-09-18 Advanced Tissue Sciences, Inc. Cells or tissues with increased protein factors and methods of making and using same
JP4354641B2 (ja) * 1998-04-03 2009-10-28 テレフオンアクチーボラゲット エル エム エリクソン（パブル） ユニバーサル移動電話システム（ｕｍｔｓ）におけるフレキシブル無線アクセス及びリソース割り当て
US6258782B1 (en) 1998-05-20 2001-07-10 Trimeris, Inc. Hybrid polypeptides with enhanced pharmacokinetic properties
RU2123837C1 (ru) 1998-05-27 1998-12-27 Бритун Юлия Анатольевна Способ устранения морщин
US6169898B1 (en) * 1998-07-16 2001-01-02 Nokia Mobile Phones Ltd Apparatus, and associated method, for maintaining a selected quality of service level in a radio communication system
ATE419273T1 (de) 1998-11-13 2009-01-15 Cyclacel Ltd Translokationsvektoren abgeleitet von der antennapedia homeodomain helix 3
US6911201B1 (en) 1999-02-04 2005-06-28 Technion Research & Development Foundation Ltd. Method of producing undifferentiated hemopoietic stem cells using a stationary phase plug-flow bioreactor
US6372494B1 (en) * 1999-05-14 2002-04-16 Advanced Tissue Sciences, Inc. Methods of making conditioned cell culture medium compositions
CA2383398C (en) * 1999-08-23 2013-06-11 Organogenesis, Inc. Skin care compositions and treatments
US6463274B1 (en) * 1999-10-26 2002-10-08 Denso Corporation Multiple class of service determination for digital cellular telephones
US6930470B2 (en) * 2001-03-01 2005-08-16 Nortel Networks Limited System and method for code division multiple access communication in a wireless communication environment
WO2002098365A2 (en) 2001-06-07 2002-12-12 Skinmedica, Inc. Conditioned cell culture media and uses thereof

Also Published As

Publication number Publication date
EP1178812A2 (de) 2002-02-13
US7118746B1 (en) 2006-10-10
US20130217069A1 (en) 2013-08-22
US20130209398A1 (en) 2013-08-15
US6372494B1 (en) 2002-04-16
CN1376067A (zh) 2002-10-23
US8138147B2 (en) 2012-03-20
NZ515476A (en) 2004-03-26
ATE311894T1 (de) 2005-12-15
US20130210076A1 (en) 2013-08-15
ES2254176T3 (es) 2006-06-16
CN1198628C (zh) 2005-04-27
JP2002544235A (ja) 2002-12-24
US20130210725A1 (en) 2013-08-15
BR0010568A (pt) 2003-02-25
MXPA01011487A (es) 2003-08-20
JP5526352B2 (ja) 2014-06-18
DE60024612T2 (de) 2006-09-14
AU772829B2 (en) 2004-05-06
HUP0201887A2 (en) 2002-09-28
AU4843000A (en) 2000-12-05
US20070077232A1 (en) 2007-04-05
JP5138129B2 (ja) 2013-02-06
US20130203169A1 (en) 2013-08-08
US20130217129A1 (en) 2013-08-22
ZA200109381B (en) 2002-11-14
RU2001133453A (ru) 2005-01-20
US8476231B2 (en) 2013-07-02
AU772829C (en) 2005-04-28
US9458486B2 (en) 2016-10-04
WO2000069449A2 (en) 2000-11-23
US20170055561A1 (en) 2017-03-02
US20120230940A1 (en) 2012-09-13
WO2000069449A3 (en) 2001-02-08
RU2280459C2 (ru) 2006-07-27
US8361485B2 (en) 2013-01-29
US20090123503A1 (en) 2009-05-14
CA2373302A1 (en) 2000-11-23
JP2013010781A (ja) 2013-01-17
EP1178812B1 (de) 2005-12-07
CA2373302C (en) 2010-11-23

Similar Documents

Publication Publication Date Title
DE60024612D1 (de) Verfahren zur herstellung von konditionierten zellkulturmedium-zusammensetzungen
GR3025710T3 (en) Use of mesomorphic phases in food products.
BG102708A (en) 4-aminopyrimidine derivatives, medicamentous preparations containing them, their application and method for their preparation
WO2001041800A3 (en) Compositions and methods for stabilizing biological molecules upon lyophilization
AU4718496A (en) Use of aerogels in agriculture
NZ512792A (en) Stable liquid interferon beta formulations
AU5501598A (en) Triazolo{4,5-(d)}pyrimidinyl derivatives and their use as medicaments
WO2001017548A3 (de) Verwendung natriuretischer peptide als antibiotisch wirksame substanzen zur behandlung von bakteriellen infektionen
MXPA03005548A (es) Metodos para la produccion de proteinas multimericas, y composiciones relacionadas.
AU2002221702A1 (en) Pharmaceutical compositions
PL336983A1 (en) Compounds, their production and application as carriers of nucleic acids in cells
WO2004071466A3 (en) Manufacturing process for liposomal preparations
PT1165558E (pt) Derivados de pirimido¬6,1-a|isoquinolina-4-ona
ES2249058T3 (es) Factores de preservacion de celulas progenitoras y metodos y productos relacionados.
CA2157836A1 (en) L-carnitine salt and cosmetic and pharmaceutical compositions containing same for treating dermatoses
AU7914600A (en) The use of baclofen in the treatment of alcohol withdrawal syndrome and to promote alcohol abstinence in alcoholics
DE69431162T2 (de) Fenbendazolformulierungen
WO2001045650A3 (de) Kosmetische verwendung von rückständen aus der weinherstellung
AU6558400A (en) Stabilisation of freeze-dried cake
DE69926881D1 (de) Zubereitungen zur aknebehandlung
GB0010314D0 (en) Anti-freeze proteins their production and use
BG101379A (en) New pypimido [1,2-a] indoles
DE50009804D1 (de) Vernetzerfreie zubereitungen
NZ333412A (en) Plant proteins treated to reduce isoflavones, manganese and nucleotides and nutritional products made therefrom
CA2145536A1 (en) Spreads

Legal Events

Date Code Title Description
8364 No opposition during term of opposition