DE60232819D1 - Verwendung von vernetztem kollagen zur behandlung von bandscheiben - Google Patents

Verwendung von vernetztem kollagen zur behandlung von bandscheiben

Info

Publication number
DE60232819D1
DE60232819D1 DE60232819T DE60232819T DE60232819D1 DE 60232819 D1 DE60232819 D1 DE 60232819D1 DE 60232819 T DE60232819 T DE 60232819T DE 60232819 T DE60232819 T DE 60232819T DE 60232819 D1 DE60232819 D1 DE 60232819D1
Authority
DE
Germany
Prior art keywords
treatment
therapeutic method
discs
belts
tissues
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60232819T
Other languages
English (en)
Inventor
Shahar Pitaru
Matitiau Noff
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Colbar LifeScience Ltd
Original Assignee
Colbar LifeScience Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Colbar LifeScience Ltd filed Critical Colbar LifeScience Ltd
Application granted granted Critical
Publication of DE60232819D1 publication Critical patent/DE60232819D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04Macromolecular materials
    • A61L31/043Proteins; Polypeptides; Degradation products thereof
    • A61L31/044Collagen
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/39Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14Macromolecular materials
    • A61L27/22Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/24Collagen
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00Materials characterised by their function or physical properties
    • A61L2400/06Flowable or injectable implant compositions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00Materials or treatment for tissue regeneration
    • A61L2430/38Materials or treatment for tissue regeneration for reconstruction of the spine, vertebrae or intervertebral discs
DE60232819T 2001-12-10 2002-12-10 Verwendung von vernetztem kollagen zur behandlung von bandscheiben Expired - Lifetime DE60232819D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US33714501P 2001-12-10 2001-12-10
PCT/IL2002/000997 WO2003049669A2 (en) 2001-12-10 2002-12-10 Methods, devices, and preparations for intervertebral disc treatment

Publications (1)

Publication Number Publication Date
DE60232819D1 true DE60232819D1 (de) 2009-08-13

Family

ID=23319301

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60232819T Expired - Lifetime DE60232819D1 (de) 2001-12-10 2002-12-10 Verwendung von vernetztem kollagen zur behandlung von bandscheiben

Country Status (11)

Country Link
US (1) US20040010251A1 (de)
EP (1) EP1465558B1 (de)
JP (1) JP2005511207A (de)
AT (1) ATE434996T1 (de)
AU (1) AU2002358957A1 (de)
BR (1) BRPI0215131A8 (de)
CA (1) CA2482309A1 (de)
DE (1) DE60232819D1 (de)
IL (1) IL162419A0 (de)
MX (1) MXPA04005707A (de)
WO (1) WO2003049669A2 (de)

Families Citing this family (77)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6402750B1 (en) * 2000-04-04 2002-06-11 Spinlabs, Llc Devices and methods for the treatment of spinal disorders
US6805695B2 (en) * 2000-04-04 2004-10-19 Spinalabs, Llc Devices and methods for annular repair of intervertebral discs
US6723335B1 (en) * 2000-04-07 2004-04-20 Jeffrey William Moehlenbruck Methods and compositions for treating intervertebral disc degeneration
US8022101B2 (en) * 2001-08-31 2011-09-20 Orthopeutics, L.P. Method of treating a knee meniscus with a cross-linking reagent to increase resistance to tearing or rupturing
TW200526203A (en) * 2001-08-31 2005-08-16 Univ Southern California Non-toxic crosslinking reagents to resist curve progression in scoliosis and increase disc permeability
US20070202143A1 (en) * 2001-08-31 2007-08-30 Hedman Thomas P Direct application of non-toxic crosslinking reagents to restabilize surgically destabilized intervertebral joints
AU2003245251A1 (en) * 2002-05-01 2003-11-17 Verigen Ag Injectable chondrocyte implant
US7744651B2 (en) * 2002-09-18 2010-06-29 Warsaw Orthopedic, Inc Compositions and methods for treating intervertebral discs with collagen-based materials
US20040054414A1 (en) * 2002-09-18 2004-03-18 Trieu Hai H. Collagen-based materials and methods for augmenting intervertebral discs
CN101198297A (zh) * 2002-09-18 2008-06-11 华沙整形外科股份有限公司 扩增椎间盘的胶原材料和方法
CN100394989C (zh) * 2002-11-15 2008-06-18 华沙整形外科股份有限公司 包含微粒状基于胶原材料的组合物的制药应用和包含所述组合物的滑膜关节
US20040186471A1 (en) * 2002-12-07 2004-09-23 Sdgi Holdings, Inc. Method and apparatus for intervertebral disc expansion
AU2004208821B2 (en) * 2003-01-31 2009-01-15 Zimmer Orthobiologics Inc. Hydrogel compositions comprising nucleus pulposus tissue
CN1774220A (zh) 2003-02-14 2006-05-17 德普伊斯派尔公司 原位成型的椎间融合器械和方法
US7344716B2 (en) * 2003-05-13 2008-03-18 Depuy Spine, Inc. Transdiscal administration of specific inhibitors of pro-inflammatory cytokines
US7452351B2 (en) 2004-04-16 2008-11-18 Kyphon Sarl Spinal diagnostic methods and apparatus
US7824390B2 (en) 2004-04-16 2010-11-02 Kyphon SÀRL Spinal diagnostic methods and apparatus
US20060122704A1 (en) * 2004-07-27 2006-06-08 Synthes Inc. Supplementation or replacement of a nucleus pulposus of an intervertebral disc
JP2008511420A (ja) 2004-08-30 2008-04-17 スピネオベイションズ・インコポレーテッド 脊髄の椎間板内障害の治療の方法
US8697139B2 (en) 2004-09-21 2014-04-15 Frank M. Phillips Method of intervertebral disc treatment using articular chondrocyte cells
US8016744B2 (en) * 2005-02-24 2011-09-13 Ethicon Endo-Surgery, Inc. External pressure-based gastric band adjustment system and method
US8366773B2 (en) 2005-08-16 2013-02-05 Benvenue Medical, Inc. Apparatus and method for treating bone
JP4944111B2 (ja) * 2005-08-16 2012-05-30 ベンベニュー メディカル, インコーポレイテッド 脊柱組織伸延装置
EP1937701A4 (de) * 2005-09-02 2009-09-16 Colbar Lifescience Ltd Quervernetzte polysaccharid- und proteinmatrizen und verfahren zu ihrer herstellung
US20070065415A1 (en) * 2005-09-16 2007-03-22 Kleinsek Donald A Compositions and methods for the augmentation and repair of defects in tissue
WO2007089233A1 (en) * 2006-02-02 2007-08-09 Tom Hedman Direct application of non-toxic crosslinking reagents to resist progressive spinal deformity
US8118779B2 (en) * 2006-06-30 2012-02-21 Warsaw Orthopedic, Inc. Collagen delivery device
US20080004703A1 (en) * 2006-06-30 2008-01-03 Warsaw Orthopedic, Inc. Method of treating a patient using a collagen material
US20080004431A1 (en) * 2006-06-30 2008-01-03 Warsaw Orthopedic Inc Method of manufacturing an injectable collagen material
US8399619B2 (en) * 2006-06-30 2013-03-19 Warsaw Orthopedic, Inc. Injectable collagen material
US20080082170A1 (en) * 2006-09-29 2008-04-03 Peterman Marc M Apparatus and methods for surgical repair
WO2008070863A2 (en) 2006-12-07 2008-06-12 Interventional Spine, Inc. Intervertebral implant
WO2008083153A2 (en) * 2006-12-28 2008-07-10 Mi4Spine, Llc Vertebral disc annular fibrosis tensioning and lengthening device
EP2124777A4 (de) * 2007-02-21 2013-06-05 Benvenue Medical Inc Vorrichtungen zur wirbelsäulenbehandlung
EP2124778B1 (de) 2007-02-21 2019-09-25 Benvenue Medical, Inc. Vorrichtungen zur wirbelsäulenbehandlung
US10278947B2 (en) 2007-02-28 2019-05-07 Orthopeutics, L.P. Crosslinker enhanced repair of connective tissues
US8864801B2 (en) * 2007-04-30 2014-10-21 Warsaw Orthopedic, Inc. Method of deformity correction in a spine using injectable materials
US8900307B2 (en) 2007-06-26 2014-12-02 DePuy Synthes Products, LLC Highly lordosed fusion cage
US8328738B2 (en) * 2007-06-29 2012-12-11 Actuated Medical, Inc. Medical tool for reduced penetration force with feedback means
US9987468B2 (en) 2007-06-29 2018-06-05 Actuated Medical, Inc. Reduced force device for intravascular access and guidewire placement
US10219832B2 (en) 2007-06-29 2019-03-05 Actuated Medical, Inc. Device and method for less forceful tissue puncture
CN101909548B (zh) 2008-01-17 2014-07-30 斯恩蒂斯有限公司 可膨胀椎间植入件以及制造它的相关方法
US8469961B2 (en) 2008-03-05 2013-06-25 Neville Alleyne Methods and compositions for minimally invasive capsular augmentation of canine coxofemoral joints
JP5441997B2 (ja) 2008-04-05 2014-03-12 ジンテス ゲゼルシャフト ミット ベシュレンクテル ハフツング 拡張可能な椎骨間インプラント
US8535327B2 (en) 2009-03-17 2013-09-17 Benvenue Medical, Inc. Delivery apparatus for use with implantable medical devices
US9526620B2 (en) 2009-03-30 2016-12-27 DePuy Synthes Products, Inc. Zero profile spinal fusion cage
US9044335B2 (en) 2009-05-05 2015-06-02 Cornell University Composite tissue-engineered intervertebral disc with self-assembled annular alignment
US8814807B2 (en) * 2009-08-19 2014-08-26 Mirador Biomedical Spinal canal access and probe positioning, devices and methods
US9393129B2 (en) 2009-12-10 2016-07-19 DePuy Synthes Products, Inc. Bellows-like expandable interbody fusion cage
EP2579765B1 (de) * 2010-06-13 2019-08-07 Omeq Medical Ltd. Vorrichtung für anatomische positionierung mit einer dehnbaren vorrichtung
US9282979B2 (en) 2010-06-24 2016-03-15 DePuy Synthes Products, Inc. Instruments and methods for non-parallel disc space preparation
US8979860B2 (en) 2010-06-24 2015-03-17 DePuy Synthes Products. LLC Enhanced cage insertion device
WO2012003175A1 (en) 2010-06-29 2012-01-05 Synthes Usa, Llc Distractible intervertebral implant
US9364568B2 (en) 2010-07-15 2016-06-14 Warsaw Orthopedic, Inc. Methods to diagnose degenerative disc disease
US9402732B2 (en) 2010-10-11 2016-08-02 DePuy Synthes Products, Inc. Expandable interspinous process spacer implant
US8814873B2 (en) 2011-06-24 2014-08-26 Benvenue Medical, Inc. Devices and methods for treating bone tissue
US8562681B2 (en) 2012-01-31 2013-10-22 Styker Spine Laminoplasty implant, method and instrumentation
US9522070B2 (en) 2013-03-07 2016-12-20 Interventional Spine, Inc. Intervertebral implant
US10085783B2 (en) 2013-03-14 2018-10-02 Izi Medical Products, Llc Devices and methods for treating bone tissue
JP7004501B2 (ja) 2013-12-03 2022-01-21 コーネル ユニバーシティー 線維輪を修復する方法及びコラーゲンゲル組成物
WO2015138328A2 (en) * 2014-03-10 2015-09-17 Medtrain Technologies, Llc Collagen hydrogel kit and methods of making a collagen hydrogel
ES2693579T3 (es) 2015-01-16 2018-12-12 Spineovations, Inc. Método de tratamiento del disco intervertebral
US11426290B2 (en) 2015-03-06 2022-08-30 DePuy Synthes Products, Inc. Expandable intervertebral implant, system, kit and method
US10940292B2 (en) 2015-07-08 2021-03-09 Actuated Medical, Inc. Reduced force device for intravascular access and guidewire placement
US11793543B2 (en) 2015-09-18 2023-10-24 Obvius Robotics, Inc. Device and method for automated insertion of penetrating member
US11510788B2 (en) 2016-06-28 2022-11-29 Eit Emerging Implant Technologies Gmbh Expandable, angularly adjustable intervertebral cages
WO2018002715A2 (en) 2016-06-28 2018-01-04 Eit Emerging Implant Technologies Gmbh Expandable and angularly adjustable articulating intervertebral cages
US10888433B2 (en) 2016-12-14 2021-01-12 DePuy Synthes Products, Inc. Intervertebral implant inserter and related methods
US10398563B2 (en) 2017-05-08 2019-09-03 Medos International Sarl Expandable cage
US11344424B2 (en) 2017-06-14 2022-05-31 Medos International Sarl Expandable intervertebral implant and related methods
US10940016B2 (en) 2017-07-05 2021-03-09 Medos International Sarl Expandable intervertebral fusion cage
US11202674B2 (en) 2018-04-03 2021-12-21 Convergent Dental, Inc. Laser system for surgical applications
US11446156B2 (en) 2018-10-25 2022-09-20 Medos International Sarl Expandable intervertebral implant, inserter instrument, and related methods
US11426286B2 (en) 2020-03-06 2022-08-30 Eit Emerging Implant Technologies Gmbh Expandable intervertebral implant
US11850160B2 (en) 2021-03-26 2023-12-26 Medos International Sarl Expandable lordotic intervertebral fusion cage
US11752009B2 (en) 2021-04-06 2023-09-12 Medos International Sarl Expandable intervertebral fusion cage
WO2022097128A1 (en) * 2021-12-22 2022-05-12 Heydarian Mohammad Surgeon robot minimally invasive laser lumbar disc surgery by pldd method

Family Cites Families (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5246457A (en) * 1985-03-28 1993-09-21 Collagen Corporation Xenogeneic collagen/mineral preparations in bone repair
US5108438A (en) * 1989-03-02 1992-04-28 Regen Corporation Prosthetic intervertebral disc
US5147514A (en) * 1987-08-02 1992-09-15 University Of North Carolina Process for cross-linking collagenous material and resulting product
US4772287A (en) * 1987-08-20 1988-09-20 Cedar Surgical, Inc. Prosthetic disc and method of implanting
AU624627B2 (en) * 1988-08-18 1992-06-18 Johnson & Johnson Orthopaedics, Inc. Functional and biocompatible intervertebral disc spacer containing elastomeric material of varying hardness
US4971954A (en) * 1988-11-23 1990-11-20 University Of Medicine And Dentistry Of New Jersey Collagen-based matrices ribose cross-linked
CA2022480C (en) * 1989-08-02 2001-02-27 Gerald L. Mechanic Process for cross-linking collagenous materials and resulting product
DE59100448D1 (de) * 1990-04-20 1993-11-11 Sulzer Ag Implantat, insbesondere Zwischenwirbelprothese.
US5192326A (en) * 1990-12-21 1993-03-09 Pfizer Hospital Products Group, Inc. Hydrogel bead intervertebral disc nucleus
US5047055A (en) * 1990-12-21 1991-09-10 Pfizer Hospital Products Group, Inc. Hydrogel intervertebral disc nucleus
JP3007903B2 (ja) * 1991-03-29 2000-02-14 京セラ株式会社 人工椎間板
US5563124A (en) * 1991-04-22 1996-10-08 Intermedics Orthopedics/ Denver, Inc. Osteogenic product and process
US5290763A (en) * 1991-04-22 1994-03-01 Intermedics Orthopedics/Denver, Inc. Osteoinductive protein mixtures and purification processes
US5800537A (en) * 1992-08-07 1998-09-01 Tissue Engineering, Inc. Method and construct for producing graft tissue from an extracellular matrix
US5534028A (en) * 1993-04-20 1996-07-09 Howmedica, Inc. Hydrogel intervertebral disc nucleus with diminished lateral bulging
US5514180A (en) * 1994-01-14 1996-05-07 Heggeness; Michael H. Prosthetic intervertebral devices
EP0717630A1 (de) * 1994-07-08 1996-06-26 SULZER Medizinaltechnik AG Verfahren zur herstellung von implantationsmaterialien
IL110367A (en) * 1994-07-19 2007-05-15 Colbar Lifescience Ltd Collagen-based matrix
EP0700671B1 (de) * 1994-09-08 2001-08-08 Stryker Technologies Corporation Bandscheibenkern aus Hydrogel
CA2201607C (en) * 1994-10-17 2001-02-13 Charles D. Ray Prosthetic spinal disc nucleus
US5824093A (en) * 1994-10-17 1998-10-20 Raymedica, Inc. Prosthetic spinal disc nucleus
US5733337A (en) * 1995-04-07 1998-03-31 Organogenesis, Inc. Tissue repair fabric
ATE200092T1 (de) * 1995-10-11 2001-04-15 Sulzer Markets & Technology Ag Verfahren zu einer photooxidativen behandlung von kollagenhaltigen geweben
JP4193917B2 (ja) * 1995-12-18 2008-12-10 アンジオデバイス インターナショナル ゲーエムベーハー 架橋ポリマー組成物およびその使用方法
US5788625A (en) * 1996-04-05 1998-08-04 Depuy Orthopaedics, Inc. Method of making reconstructive SIS structure for cartilaginous elements in situ
US6620155B2 (en) * 1996-07-16 2003-09-16 Arthrocare Corp. System and methods for electrosurgical tissue contraction within the spine
US5964807A (en) * 1996-08-08 1999-10-12 Trustees Of The University Of Pennsylvania Compositions and methods for intervertebral disc reformation
US6126682A (en) * 1996-08-13 2000-10-03 Oratec Interventions, Inc. Method for treating annular fissures in intervertebral discs
US5800549A (en) * 1997-04-30 1998-09-01 Howmedica Inc. Method and apparatus for injecting an elastic spinal implant
US6022376A (en) * 1997-06-06 2000-02-08 Raymedica, Inc. Percutaneous prosthetic spinal disc nucleus and method of manufacture
US5865833A (en) * 1997-11-24 1999-02-02 S.L.T. Japan Co., Ltd. Apparatus for laser treatment
US6258125B1 (en) * 1998-08-03 2001-07-10 Synthes (U.S.A.) Intervertebral allograft spacer
FR2787992B1 (fr) * 1999-01-04 2001-04-20 Aesculap Sa Prothese tibiale du genou a rotule a double inserts
US6585972B2 (en) * 1999-03-09 2003-07-01 Gholam A. Peyman Process for crosslinking of collagen in the vitreous of the eye and inducing separation of the posterior hyaloid from the retina
US6240925B1 (en) * 1999-03-23 2001-06-05 Cynosure, Inc. Photothermal vascular targeting with bioreductive agents
US6428576B1 (en) * 1999-04-16 2002-08-06 Endospine, Ltd. System for repairing inter-vertebral discs
US6719797B1 (en) * 1999-08-13 2004-04-13 Bret A. Ferree Nucleus augmentation with in situ formed hydrogels
US6283968B1 (en) * 2000-03-07 2001-09-04 Hamid M. Mehdizadeh Posterior laminectomy procedure
US6723335B1 (en) 2000-04-07 2004-04-20 Jeffrey William Moehlenbruck Methods and compositions for treating intervertebral disc degeneration
US6682760B2 (en) * 2000-04-18 2004-01-27 Colbar R&D Ltd. Cross-linked collagen matrices and methods for their preparation
US20020176893A1 (en) * 2001-02-02 2002-11-28 Wironen John F. Compositions, implants, methods, and kits for closure of lumen openings, repair of ruptured tissue, and for bulking of tissue
US20030069639A1 (en) * 2001-04-14 2003-04-10 Tom Sander Methods and compositions for repair or replacement of joints and soft tissues
AU2002336694A1 (en) * 2001-11-01 2003-05-12 Lawrence M. Boyd Devices and methods for the restoration of a spinal disc
US20040054414A1 (en) * 2002-09-18 2004-03-18 Trieu Hai H. Collagen-based materials and methods for augmenting intervertebral discs

Also Published As

Publication number Publication date
CA2482309A1 (en) 2003-06-19
MXPA04005707A (es) 2005-06-20
WO2003049669A2 (en) 2003-06-19
EP1465558A2 (de) 2004-10-13
WO2003049669A3 (en) 2004-03-11
IL162419A0 (en) 2005-11-20
ATE434996T1 (de) 2009-07-15
AU2002358957A1 (en) 2003-06-23
BR0215131A (pt) 2005-04-26
EP1465558A4 (de) 2005-03-16
BRPI0215131A8 (pt) 2017-09-12
EP1465558B1 (de) 2009-07-01
US20040010251A1 (en) 2004-01-15
JP2005511207A (ja) 2005-04-28

Similar Documents

Publication Publication Date Title
DE60232819D1 (de) Verwendung von vernetztem kollagen zur behandlung von bandscheiben
US8082038B2 (en) Method for treating degenerative disc disease using noninvasive capacitively coupled electrical stimulation device
MXPA03002600A (es) Tratamiento novedoso de columna vertebral de intervencion temprana, metodos y dispositivos para uso en el mismo.
US9795802B2 (en) Method of orthopedic treatment by radiation
Ronga et al. Recombinant human bone morphogenetic protein-7 for treatment of long bone non-union: an observational, retrospective, non-randomized study of 105 patients
Yamamoto et al. Progress in biological reconstruction and enhanced bone revitalization for bone defects
RU2527150C1 (ru) Способ реконструкции поясничного позвоночно-двигательного сегмента
SU1468543A1 (ru) Способ лечени больных с артрозом дугоотростчатых суставов позвоночника
RU2614219C1 (ru) Способ заднего межтелового спондилодеза
RU2393799C1 (ru) Способ лечения стеноза спинномозгового канала поясничного отдела позвоночника
RU2294169C1 (ru) Способ хирургического лечения грыж межпозвонковых дисков поясничного отдела позвоночника
RU2422114C2 (ru) Способ и система для создания контролируемых неоднородностей структуры и механических напряжений в хрящевых тканях (варианты), а также способ введения лекарственных и других полезных веществ для контролируемой активации регенерационных процессов (варианты)
EA200500963A1 (ru) Способ лечения грыж межпозвонковых дисков
US20120035683A1 (en) Method for treating degenerative disc disease using noninvasive capacitively coupled electrical stimulation device
RU2614360C1 (ru) Способ лечения гематогенного остеомиелита позвоночника
Papadakis et al. Screw Fixation as the Primary and Definitive Treatment of an Isolated Uncommon Fracture of the Anterior Margin of the Distal Tibia
Miller et al. Regenerative surgery & intra-operative protocols utilizing bone marrow aspirate concentrate in microsurgical & limb reconstruction
JPH0638936U (ja) 人工骨スペーサー
RU2356505C1 (ru) Способ хирургической коррекции дефектов дистальных отделов бедренной кости
RU2187974C2 (ru) Способ хирургической профилактики фиброза в эпидуральном пространстве
RU2147212C1 (ru) Способ лечения ложных суставов и асептических некрозов костей проксимального ряда запястья кисти
RU2157670C2 (ru) Способ лечения облитерирующих заболеваний сосудов нижних конечностей
Apuzzo et al. A Case of Inflammatory Reduction with Ozone Treatment of Disc Herniation and Histological Changes
Iwamoto et al. Surgical treatment of metastatic tumors of long bones and the spine
RU2250116C2 (ru) Способ лечения радикулярного болевого синдрома

Legal Events

Date Code Title Description
8364 No opposition during term of opposition