DE60305227D1 - Bandscheibenbehandlung mit einem Vernetzer und einem Inaktivator oder Stabilisator - Google Patents
Bandscheibenbehandlung mit einem Vernetzer und einem Inaktivator oder StabilisatorInfo
- Publication number
- DE60305227D1 DE60305227D1 DE60305227T DE60305227T DE60305227D1 DE 60305227 D1 DE60305227 D1 DE 60305227D1 DE 60305227 T DE60305227 T DE 60305227T DE 60305227 T DE60305227 T DE 60305227T DE 60305227 D1 DE60305227 D1 DE 60305227D1
- Authority
- DE
- Germany
- Prior art keywords
- disc
- inactivator
- crosslinker
- stabilizer
- disc treatment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
- A61L27/3612—Cartilage, synovial fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
- A61L27/24—Collagen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3641—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the site of application in the body
- A61L27/3645—Connective tissue
- A61L27/3654—Cartilage, e.g. meniscus
- A61L27/3658—Intervertebral discs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/38—Materials or treatment for tissue regeneration for reconstruction of the spine, vertebrae or intervertebral discs
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US102075 | 2002-03-19 | ||
US10/102,075 US6812211B2 (en) | 2002-03-19 | 2002-03-19 | Method for nonsurgical treatment of the intervertebral disc and kit therefor |
Publications (2)
Publication Number | Publication Date |
---|---|
DE60305227D1 true DE60305227D1 (de) | 2006-06-22 |
DE60305227T2 DE60305227T2 (de) | 2007-03-01 |
Family
ID=27788354
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60305227T Expired - Lifetime DE60305227T2 (de) | 2002-03-19 | 2003-03-19 | Bandscheibenbehandlung mit einem Vernetzer und einem Inaktivator oder Stabilisator |
Country Status (7)
Country | Link |
---|---|
US (2) | US6812211B2 (de) |
EP (1) | EP1346736B1 (de) |
JP (1) | JP2003299741A (de) |
AT (1) | ATE326244T1 (de) |
AU (1) | AU2003201348B2 (de) |
CA (1) | CA2422657A1 (de) |
DE (1) | DE60305227T2 (de) |
Families Citing this family (54)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6592625B2 (en) | 1999-10-20 | 2003-07-15 | Anulex Technologies, Inc. | Spinal disc annulus reconstruction method and spinal disc annulus stent |
US8632590B2 (en) | 1999-10-20 | 2014-01-21 | Anulex Technologies, Inc. | Apparatus and methods for the treatment of the intervertebral disc |
US8128698B2 (en) | 1999-10-20 | 2012-03-06 | Anulex Technologies, Inc. | Method and apparatus for the treatment of the intervertebral disc annulus |
US7935147B2 (en) | 1999-10-20 | 2011-05-03 | Anulex Technologies, Inc. | Method and apparatus for enhanced delivery of treatment device to the intervertebral disc annulus |
US7004970B2 (en) | 1999-10-20 | 2006-02-28 | Anulex Technologies, Inc. | Methods and devices for spinal disc annulus reconstruction and repair |
US7052516B2 (en) | 1999-10-20 | 2006-05-30 | Anulex Technologies, Inc. | Spinal disc annulus reconstruction method and deformable spinal disc annulus stent |
US7615076B2 (en) | 1999-10-20 | 2009-11-10 | Anulex Technologies, Inc. | Method and apparatus for the treatment of the intervertebral disc annulus |
US7951201B2 (en) | 1999-10-20 | 2011-05-31 | Anulex Technologies, Inc. | Method and apparatus for the treatment of the intervertebral disc annulus |
US6723335B1 (en) * | 2000-04-07 | 2004-04-20 | Jeffrey William Moehlenbruck | Methods and compositions for treating intervertebral disc degeneration |
AU2004268628B2 (en) * | 2001-08-31 | 2009-11-12 | Spinal Simplicity, Llc | Crosslinking reagents for treating intervertebral disc disorders |
US20080260712A1 (en) * | 2001-08-31 | 2008-10-23 | University Of Southern California | Non-toxic crosslinking reagents to resist curve progression in scoliosis and increase disc permeability |
US8022101B2 (en) * | 2001-08-31 | 2011-09-20 | Orthopeutics, L.P. | Method of treating a knee meniscus with a cross-linking reagent to increase resistance to tearing or rupturing |
US8153600B2 (en) * | 2001-08-31 | 2012-04-10 | Orthopeutics, L.P. | Direct application of non-toxic crosslinking reagents to resist progressive spinal deformity |
US7435722B2 (en) * | 2001-08-31 | 2008-10-14 | University Of Southern California | Non-toxic crosslinking reagents to resist curve progression in scoliosis and increase disc permeability |
US20070202143A1 (en) * | 2001-08-31 | 2007-08-30 | Hedman Thomas P | Direct application of non-toxic crosslinking reagents to restabilize surgically destabilized intervertebral joints |
WO2012006095A1 (en) | 2010-06-28 | 2012-01-12 | Hedman Thomas P | Tissue crosslinking for treatment of snoring and obstructive sleep apnea |
US8119599B2 (en) * | 2001-08-31 | 2012-02-21 | Orthopeutics, L.P. | Direct application of non-toxic crosslinking reagents to resist progressive spinal degeneration and deformity |
CN1578624A (zh) * | 2001-08-31 | 2005-02-09 | 南加利福尼亚大学 | 无毒性交联试剂在增强椎间盘及其他白纤维组织的抗疲劳性并减轻其机械性退化中的用途 |
US6812211B2 (en) * | 2002-03-19 | 2004-11-02 | Michael Andrew Slivka | Method for nonsurgical treatment of the intervertebral disc and kit therefor |
US20050209699A1 (en) * | 2002-03-19 | 2005-09-22 | Slivka Michael A | Method for nonsurgical treatment of the nucleus pulposus of the intervertebral disc using genipin or proanthrocyanidin, and kit therefor |
US20040138204A1 (en) * | 2002-10-30 | 2004-07-15 | Harrington James Frederick | Compositions and methods for pain reduction |
CA2513055A1 (en) * | 2003-01-31 | 2004-08-19 | Zimmer Orthobiologics, Inc. | Hydrogel compositions comprising nucleus pulposus tissue |
EP1682161A4 (de) * | 2003-10-29 | 2011-12-07 | Gentis Inc | Polymerisierbare emulsionen für die gewebeherstellung |
CA2458159A1 (en) * | 2004-01-22 | 2005-07-22 | The State Of Oregon Acting By And Through The State Board Of Higher Educ Ation On Behalf Of Oregon State University | Formaldehyde-free adhesives and lignocellulosic composites made from the adhesives |
US7824390B2 (en) | 2004-04-16 | 2010-11-02 | Kyphon SÀRL | Spinal diagnostic methods and apparatus |
US7452351B2 (en) | 2004-04-16 | 2008-11-18 | Kyphon Sarl | Spinal diagnostic methods and apparatus |
JP4722837B2 (ja) * | 2004-05-07 | 2011-07-13 | 生化学工業株式会社 | 髄核充填剤 |
US8206448B2 (en) | 2004-10-29 | 2012-06-26 | Spinal Restoration, Inc. | Injection of fibrin sealant using reconstituted components in spinal applications |
US7597687B2 (en) | 2004-10-29 | 2009-10-06 | Spinal Restoration, Inc. | Injection of fibrin sealant including an anesthetic in spinal applications |
US20090181892A1 (en) * | 2004-07-16 | 2009-07-16 | Spinal Restoration, Inc. | Methods and kits for treating joints and soft tissues |
US20120143341A1 (en) * | 2006-12-12 | 2012-06-07 | Arthrodisc, L.L.C. | Devices and methods for visual differentiation of intervertebral spaces |
US20070093905A1 (en) * | 2005-10-21 | 2007-04-26 | O'neil Michael J | Degenerative disc regeneration techniques |
US8197545B2 (en) | 2005-10-27 | 2012-06-12 | Depuy Spine, Inc. | Nucleus augmentation delivery device and technique |
JP2009525327A (ja) * | 2006-02-02 | 2009-07-09 | ヘドマン,トム | 進行性の脊髄の奇形に抵抗する非毒性架橋試薬の直接的なアプリケーション |
US7727725B2 (en) * | 2006-04-27 | 2010-06-01 | Celera Corporation | Genetic polymorphisms associated with liver fibrosis, methods of detection and uses thereof |
US20080082104A1 (en) | 2006-07-27 | 2008-04-03 | Lanx, Llc | Methods and apparatuses for facilitating percutaneous fusion |
US20080027554A1 (en) * | 2006-07-31 | 2008-01-31 | Talmadge Karen D | Kit and methods of treatment of an intervertebral disc |
US20080097229A1 (en) * | 2006-08-29 | 2008-04-24 | Josee Roy | Hygroscopic treatment for degenerating discs |
WO2008101100A2 (en) * | 2007-02-14 | 2008-08-21 | Indiana University Research And Technology Corporation | Composition for stimulating formation of vascular structures |
US10278947B2 (en) | 2007-02-28 | 2019-05-07 | Orthopeutics, L.P. | Crosslinker enhanced repair of connective tissues |
WO2011150218A1 (en) * | 2010-05-27 | 2011-12-01 | Hedman Thomas P | Crosslinker enhanced repair of knee meniscus |
US20100035297A1 (en) * | 2008-08-08 | 2010-02-11 | Indiana University Research And Technology Corporation | Methods and compositions for vasculogenic potential determination |
US8198248B2 (en) * | 2008-08-15 | 2012-06-12 | Orthopeutics, Lp | Formulations for nonsurgical exogenous crosslink therapy |
US20100040593A1 (en) * | 2008-08-15 | 2010-02-18 | Orthopeutics, Lp | Formulations for nonsurgical exogenous crosslink therapy |
US8283322B2 (en) * | 2008-08-15 | 2012-10-09 | Orthopeutics, Lp | Formulations for nonsurgical exogenous crosslink therapy |
US8163022B2 (en) | 2008-10-14 | 2012-04-24 | Anulex Technologies, Inc. | Method and apparatus for the treatment of the intervertebral disc annulus |
US9132207B2 (en) * | 2009-10-27 | 2015-09-15 | Spine Wave, Inc. | Radiopaque injectable nucleus hydrogel compositions |
FR2952306B1 (fr) * | 2009-11-09 | 2012-03-30 | Creaspine | Composition aqueuse utilisee dans le traitement de la reparation de tissu conjonctif fibreux par laser |
US8652153B2 (en) | 2010-01-11 | 2014-02-18 | Anulex Technologies, Inc. | Intervertebral disc annulus repair system and bone anchor delivery tool |
CN103007351B (zh) * | 2013-01-05 | 2014-08-20 | 天津市天津医院 | 纤维环与髓核一体化复合双相支架及其构建方法 |
US9737294B2 (en) | 2013-01-28 | 2017-08-22 | Cartiva, Inc. | Method and system for orthopedic repair |
US10179012B2 (en) | 2013-01-28 | 2019-01-15 | Cartiva, Inc. | Systems and methods for orthopedic repair |
US20160303284A1 (en) * | 2013-12-03 | 2016-10-20 | Cornell University | Method of repairing an annulus and collagen gel composition |
GB2586577B (en) * | 2019-06-14 | 2024-03-27 | Gelmetix Ltd | Diagnosis and treatment |
Family Cites Families (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4716224A (en) | 1984-05-04 | 1987-12-29 | Seikagaku Kogyo Co. Ltd. | Crosslinked hyaluronic acid and its use |
AU563019B2 (en) * | 1984-05-21 | 1987-06-25 | H.B. Fuller Licensing And Financing Inc. | Starch-based corrugating adhesive containing soluble polyvinyl alcohol |
FR2601371B1 (fr) | 1986-07-11 | 1989-05-12 | Merieux Inst | Procede de traitement du collagene en vue, notamment, d'en faciliter la reticulation et collagene obtenu par application dudit procede |
US5024742A (en) | 1988-02-24 | 1991-06-18 | Cedars-Sinai Medical Center | Method of crosslinking amino acid containing polymers using photoactivatable chemical crosslinkers |
US5510418A (en) | 1988-11-21 | 1996-04-23 | Collagen Corporation | Glycosaminoglycan-synthetic polymer conjugates |
US5306500A (en) * | 1988-11-21 | 1994-04-26 | Collagen Corporation | Method of augmenting tissue with collagen-polymer conjugates |
US5888220A (en) | 1994-05-06 | 1999-03-30 | Advanced Bio Surfaces, Inc. | Articulating joint repair |
WO1995031946A1 (en) | 1994-05-24 | 1995-11-30 | Smith & Nephew Plc | Intervertebral disc implant |
WO1995034332A1 (en) | 1994-06-15 | 1995-12-21 | St. Jude Medical, Inc. | Enhanced cross-linking of natural tissues |
US6231608B1 (en) | 1995-06-07 | 2001-05-15 | Crosscart, Inc. | Aldehyde and glycosidase-treated soft and bone tissue xenografts |
EP1704878B1 (de) * | 1995-12-18 | 2013-04-10 | AngioDevice International GmbH | Quervernetzte Polymerzusammensetzungen und Verfahren zu ihrer Verwendung |
CA2263717A1 (en) * | 1996-08-12 | 1998-02-19 | Fujisawa Pharmaceutical Co., Ltd. | Methods for preparing bioreactors |
US6126682A (en) | 1996-08-13 | 2000-10-03 | Oratec Interventions, Inc. | Method for treating annular fissures in intervertebral discs |
FR2754268B1 (fr) | 1996-10-07 | 1998-12-24 | Dev Des Utilisations Du Collag | Composition adhesive a base de polyaldehyde macromoleculaire et procede de reticulation de collagene ou de gelatine |
US5866165A (en) | 1997-01-15 | 1999-02-02 | Orquest, Inc. | Collagen-polysaccharide matrix for bone and cartilage repair |
US6165485A (en) * | 1998-07-28 | 2000-12-26 | Biomin, Inc. | Biocidal organoclay |
DE69933686T2 (de) | 1998-10-06 | 2007-08-23 | Rush University Medical Center, Chicago | Zusammensetzung zur verwendung in der chemonukleolyse |
US6206921B1 (en) | 1999-02-22 | 2001-03-27 | Peter A. Guagliano | Method of replacing nucleus pulposus and repairing the intervertebral disk |
US6375672B1 (en) | 1999-03-22 | 2002-04-23 | Board Of Trustees Of Michigan State University | Method for controlling the chemical and heat induced responses of collagenous materials |
US6312725B1 (en) * | 1999-04-16 | 2001-11-06 | Cohesion Technologies, Inc. | Rapid gelling biocompatible polymer composition |
US6428576B1 (en) | 1999-04-16 | 2002-08-06 | Endospine, Ltd. | System for repairing inter-vertebral discs |
EP1202706A1 (de) | 1999-07-22 | 2002-05-08 | Pericor Science, Inc. | Lysinoxidase als verbindungsmittel für gewebe |
US6723335B1 (en) | 2000-04-07 | 2004-04-20 | Jeffrey William Moehlenbruck | Methods and compositions for treating intervertebral disc degeneration |
AU1538702A (en) * | 2000-10-24 | 2002-05-06 | Cryolife Inc | In situ bioprosthetic filler and methods, particularly for the in situ formationof vertebral disc bioprosthetics |
US20020176893A1 (en) * | 2001-02-02 | 2002-11-28 | Wironen John F. | Compositions, implants, methods, and kits for closure of lumen openings, repair of ruptured tissue, and for bulking of tissue |
US6605570B2 (en) * | 2001-03-01 | 2003-08-12 | Schlumberger Technology Corporation | Compositions and methods to control fluid loss in surfactant-based wellbore service fluids |
US7435722B2 (en) * | 2001-08-31 | 2008-10-14 | University Of Southern California | Non-toxic crosslinking reagents to resist curve progression in scoliosis and increase disc permeability |
CN1578624A (zh) * | 2001-08-31 | 2005-02-09 | 南加利福尼亚大学 | 无毒性交联试剂在增强椎间盘及其他白纤维组织的抗疲劳性并减轻其机械性退化中的用途 |
US6812211B2 (en) * | 2002-03-19 | 2004-11-02 | Michael Andrew Slivka | Method for nonsurgical treatment of the intervertebral disc and kit therefor |
US20040054414A1 (en) * | 2002-09-18 | 2004-03-18 | Trieu Hai H. | Collagen-based materials and methods for augmenting intervertebral discs |
-
2002
- 2002-03-19 US US10/102,075 patent/US6812211B2/en not_active Expired - Lifetime
-
2003
- 2003-03-18 JP JP2003074205A patent/JP2003299741A/ja active Pending
- 2003-03-18 AU AU2003201348A patent/AU2003201348B2/en not_active Ceased
- 2003-03-19 EP EP03251687A patent/EP1346736B1/de not_active Expired - Lifetime
- 2003-03-19 CA CA002422657A patent/CA2422657A1/en not_active Abandoned
- 2003-03-19 DE DE60305227T patent/DE60305227T2/de not_active Expired - Lifetime
- 2003-03-19 AT AT03251687T patent/ATE326244T1/de not_active IP Right Cessation
-
2004
- 2004-09-09 US US10/938,197 patent/US7294617B2/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
EP1346736A1 (de) | 2003-09-24 |
AU2003201348B2 (en) | 2007-11-29 |
US20050038518A1 (en) | 2005-02-17 |
CA2422657A1 (en) | 2003-09-19 |
DE60305227T2 (de) | 2007-03-01 |
ATE326244T1 (de) | 2006-06-15 |
US7294617B2 (en) | 2007-11-13 |
JP2003299741A (ja) | 2003-10-21 |
US20030181365A1 (en) | 2003-09-25 |
US6812211B2 (en) | 2004-11-02 |
AU2003201348A1 (en) | 2003-10-09 |
EP1346736B1 (de) | 2006-05-17 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |