DE69027319T2 - Inhalationsvorrichtung für trockenpulver - Google Patents

Inhalationsvorrichtung für trockenpulver

Info

Publication number
DE69027319T2
DE69027319T2 DE69027319T DE69027319T DE69027319T2 DE 69027319 T2 DE69027319 T2 DE 69027319T2 DE 69027319 T DE69027319 T DE 69027319T DE 69027319 T DE69027319 T DE 69027319T DE 69027319 T2 DE69027319 T2 DE 69027319T2
Authority
DE
Germany
Prior art keywords
patient
inhalation device
aerosolisation
dry powder
deagglomeration
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69027319T
Other languages
English (en)
Other versions
DE69027319D1 (de
Inventor
Peter Hodson
David Smith
Anthony Wass
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Riker Laboratories Inc
Original Assignee
Riker Laboratories Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB898909891A external-priority patent/GB8909891D0/en
Application filed by Riker Laboratories Inc filed Critical Riker Laboratories Inc
Application granted granted Critical
Publication of DE69027319D1 publication Critical patent/DE69027319D1/de
Publication of DE69027319T2 publication Critical patent/DE69027319T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0001—Details of inhalators; Constructional features thereof
    • A61M15/0013—Details of inhalators; Constructional features thereof with inhalation check valves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0001—Details of inhalators; Constructional features thereof
    • A61M15/0013—Details of inhalators; Constructional features thereof with inhalation check valves
    • A61M15/0016—Details of inhalators; Constructional features thereof with inhalation check valves located downstream of the dispenser, i.e. traversed by the product
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0001—Details of inhalators; Constructional features thereof
    • A61M15/0018—Details of inhalators; Constructional features thereof with exhalation check valves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0001—Details of inhalators; Constructional features thereof
    • A61M15/0021—Mouthpieces therefor
    • A61M15/0025—Mouthpieces therefor with caps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/003—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
    • A61M15/0043—Non-destructive separation of the package, e.g. peeling
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/0045—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/0045—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters
    • A61M15/0046—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters characterized by the type of carrier
    • A61M15/0048—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters characterized by the type of carrier the dosages being arranged in a plane, e.g. on diskettes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/0045—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters
    • A61M15/0046—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters characterized by the type of carrier
    • A61M15/0051—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters characterized by the type of carrier the dosages being arranged on a tape, e.g. strips
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/0045—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters
    • A61M15/0053—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters characterized by the type or way of disposal
    • A61M15/0055—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters characterized by the type or way of disposal the used dosages being coiled
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0091—Inhalators mechanically breath-triggered
    • A61M15/0093—Inhalators mechanically breath-triggered without arming or cocking, e.g. acting directly on the delivery valve
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0065—Inhalators with dosage or measuring devices
    • A61M15/0068—Indicating or counting the number of dispensed doses or of remaining doses
    • A61M15/007—Mechanical counters
    • A61M15/0071—Mechanical counters having a display or indicator
    • A61M15/0078—Mechanical counters having a display or indicator on a strip
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0085—Inhalators using ultrasonics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0091—Inhalators mechanically breath-triggered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/02—Inhalators with activated or ionised fluids, e.g. electrohydrodynamic [EHD] or electrostatic devices; Ozone-inhalators with radioactive tagged particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
    • A61M16/0003—Accessories therefor, e.g. sensors, vibrators, negative pressure
    • A61M2016/0015—Accessories therefor, e.g. sensors, vibrators, negative pressure inhalation detectors
    • A61M2016/0018—Accessories therefor, e.g. sensors, vibrators, negative pressure inhalation detectors electrical
    • A61M2016/0024—Accessories therefor, e.g. sensors, vibrators, negative pressure inhalation detectors electrical with an on-off output signal, e.g. from a switch
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/06—Solids
    • A61M2202/064—Powder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/82—Internal energy supply devices
    • A61M2205/8206—Internal energy supply devices battery-operated
DE69027319T 1989-04-28 1990-04-30 Inhalationsvorrichtung für trockenpulver Expired - Fee Related DE69027319T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB898909891A GB8909891D0 (en) 1989-04-28 1989-04-28 Device
GB909000261A GB9000261D0 (en) 1989-04-28 1990-01-05 Device
PCT/GB1990/000670 WO1990013327A1 (en) 1989-04-28 1990-04-30 Dry powder inhalation device

Publications (2)

Publication Number Publication Date
DE69027319D1 DE69027319D1 (de) 1996-07-11
DE69027319T2 true DE69027319T2 (de) 1996-11-21

Family

ID=26295297

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69034007T Expired - Fee Related DE69034007T2 (de) 1989-04-28 1990-04-30 Inhalationsvorrichtung für Trockenpulver
DE69027319T Expired - Fee Related DE69027319T2 (de) 1989-04-28 1990-04-30 Inhalationsvorrichtung für trockenpulver

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE69034007T Expired - Fee Related DE69034007T2 (de) 1989-04-28 1990-04-30 Inhalationsvorrichtung für Trockenpulver

Country Status (10)

Country Link
US (2) US5655523A (de)
EP (2) EP0470154B1 (de)
JP (1) JPH05501505A (de)
AT (2) ATE138814T1 (de)
AU (1) AU643435B2 (de)
CA (1) CA2058764A1 (de)
DE (2) DE69034007T2 (de)
DK (1) DK0470154T3 (de)
ES (1) ES2087911T3 (de)
WO (1) WO1990013327A1 (de)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19956260A1 (de) * 1999-11-23 2001-05-31 Inamed Gmbh Abscheidevorrichtung, insbesondere für Trockenpulvermedikamente in Aerosolform

Families Citing this family (277)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8909891D0 (en) * 1989-04-28 1989-06-14 Riker Laboratories Inc Device
EP0470154B1 (de) * 1989-04-28 1996-06-05 Riker Laboratories, Inc. Inhalationsvorrichtung für trockenpulver
GB9004781D0 (en) * 1990-03-02 1990-04-25 Glaxo Group Ltd Device
SK280967B6 (sk) * 1990-03-02 2000-10-09 Glaxo Group Limited Inhalačný prístroj
PL165973B1 (pl) * 1990-06-28 1995-03-31 Boehringer Ingelheim Kg zawierajacego proszkowy srodek leczniczy PL PL PL PL PL PL PL PL
GB9016789D0 (en) * 1990-07-31 1990-09-12 Lilly Industries Ltd Medicament administering devices
GB9027255D0 (en) * 1990-12-17 1991-02-06 Minnesota Mining & Mfg Closure system for inhalers
FR2676929B1 (fr) * 1991-05-30 1994-02-11 Aerosols Bouchage Ste Fse Inhalateur de poudres.
ES2086759T3 (es) * 1991-06-26 1996-07-01 Schering Corp Dispositivo de inhalacion para medicamentos en polvo.
CA2093809A1 (en) * 1991-08-15 1993-02-16 Franco Del Bon Inhaler
US6119688A (en) * 1991-08-26 2000-09-19 3M Innovative Properties Company Powder dispenser
US5469843A (en) * 1991-11-12 1995-11-28 Minnesota Mining And Manufacturing Company Inhalation device
US5394868A (en) * 1992-06-25 1995-03-07 Schering Corporation Inhalation device for powdered medicaments
GB2273660B (en) * 1992-09-11 1996-07-17 Aid Medic Ltd Drug delivery arrangement
CZ282964B6 (cs) * 1992-10-19 1997-11-12 Dura Pharmaceuticals, Inc. Inhalátor pro inhalování suchého prášku
SE9203570D0 (sv) * 1992-11-27 1992-11-27 Astra Ab Inhaler for multiple use
US6024090A (en) * 1993-01-29 2000-02-15 Aradigm Corporation Method of treating a diabetic patient by aerosolized administration of insulin lispro
US7448375B2 (en) * 1993-01-29 2008-11-11 Aradigm Corporation Method of treating diabetes mellitus in a patient
US5441060A (en) * 1993-02-08 1995-08-15 Duke University Dry powder delivery system
WO1994023772A2 (en) * 1993-04-06 1994-10-27 Minnesota Mining And Manufacturing Company Deagglomerators for dry powder inhalers
US5497763A (en) * 1993-05-21 1996-03-12 Aradigm Corporation Disposable package for intrapulmonary delivery of aerosolized formulations
US5709202A (en) * 1993-05-21 1998-01-20 Aradigm Corporation Intrapulmonary delivery of aerosolized formulations
GB9314614D0 (en) * 1993-07-14 1993-08-25 Minnesota Mining & Mfg Dry powder inhalers
GB9324391D0 (en) * 1993-11-26 1994-01-12 Minnesota Mining & Mfg Device for transmission of one-way torque
GB9326574D0 (en) * 1993-12-31 1994-03-02 King S College London Dry power inhalers
PE44995A1 (es) * 1994-01-27 1995-12-18 Schering Corp Furoato de mometasona para el tratamiento de las enfermedades pulmonares y de las vias respiratorias
US20030113273A1 (en) * 1996-06-17 2003-06-19 Patton John S. Methods and compositions for pulmonary delivery of insulin
ES2218543T3 (es) 1994-03-07 2004-11-16 Nektar Therapeutics Procedimiento y preparacion para la administracion de insulina por via pulmonar.
US5983956A (en) * 1994-10-03 1999-11-16 Astra Aktiebolag Formulation for inhalation
US5980949A (en) * 1994-10-03 1999-11-09 Astra Aktiebolag Formulation for inhalation
US5647347A (en) * 1994-10-21 1997-07-15 Glaxo Wellcome Inc. Medicament carrier for dry powder inhalator
JP3308425B2 (ja) * 1995-03-10 2002-07-29 株式会社ユニシアジェックス 鼻腔用投薬器
SE9502800D0 (sv) * 1995-08-10 1995-08-10 Astra Ab Disposable inhaler
US5694920A (en) * 1996-01-25 1997-12-09 Abrams; Andrew L. Inhalation device
US6026809A (en) * 1996-01-25 2000-02-22 Microdose Technologies, Inc. Inhalation device
US5944012A (en) * 1996-03-25 1999-08-31 Pera; Ivo E. Method for dispensing antioxidant vitamins by inhalation background of the invention
JP2000510109A (ja) * 1996-04-29 2000-08-08 デュラ・ファーマシューティカルズ・インコーポレイテッド 乾燥粉末の吸入方法
US5871010A (en) * 1996-06-10 1999-02-16 Sarnoff Corporation Inhaler apparatus with modified surfaces for enhanced release of dry powders
GB2320489A (en) * 1996-12-20 1998-06-24 Norton Healthcare Ltd Inhaler dose counter
JP2001513078A (ja) 1996-12-30 2001-08-28 バテル・メモリアル・インスティテュート 吸入により新生物を治療する製剤とその方法
SE9700133D0 (sv) * 1997-01-20 1997-01-20 Astra Ab New formulation
SE9700135D0 (sv) * 1997-01-20 1997-01-20 Astra Ab New formulation
SE9700937D0 (sv) 1997-03-14 1997-03-14 Astra Ab Powder inhaler I
SE9700936D0 (sv) * 1997-03-14 1997-03-14 Astra Ab Inhalation device
TW469832U (en) 1997-03-14 2001-12-21 Astra Ab Inhalation device
US5881720A (en) * 1997-04-29 1999-03-16 The Procter & Gamble Company Method of delivering halotherapy
NL1006058C2 (nl) * 1997-05-14 1998-11-17 R & D Injector Ag Doseerinrichting.
ZA989744B (en) * 1997-10-31 2000-04-26 Lilly Co Eli Method for administering acylated insulin.
FI105074B (fi) 1997-12-31 2000-06-15 Leiras Oy Farmaseuttisen formulaation valmistusmenetelmä
RO121834B1 (ro) * 1998-03-16 2008-06-30 Inhale Therapeutic Systems, Inc. Dispozitiv pentru administrarea unui agent activ
US6142146A (en) * 1998-06-12 2000-11-07 Microdose Technologies, Inc. Inhalation device
US6152130A (en) * 1998-06-12 2000-11-28 Microdose Technologies, Inc. Inhalation device with acoustic control
ES2253898T3 (es) * 1998-06-12 2006-06-01 Microdose Technologies Inc. Dispositivo para la administracion de farmacos y medicamentos.
SE512433C2 (sv) * 1998-07-30 2000-03-13 Microdrug Ag Förfarande för finfördelning och elektrostatisk uppladdning av ett pulver avsett för administrering främst genom inhalation jämte anordning för matning, finfördelning och elektrostatisk uppladdning av ett pulver avsett för administrering främst genom inhalation
SE512386C2 (sv) * 1998-07-30 2000-03-06 Microdrug Ag Förfarande och anordning för klassificering av elektrostatiskt laddat pulverformigt material
UA73924C2 (en) * 1998-10-09 2005-10-17 Nektar Therapeutics Device for delivering active agent formulation to lungs of human patient
GB9825118D0 (en) * 1998-11-16 1999-01-13 Minnesota Mining & Mfg Breath-actuated aerosol dispensers
GB2345010B (en) * 1998-12-17 2002-12-31 Electrosols Ltd A delivery device
US6752148B1 (en) * 1999-02-10 2004-06-22 Delsys Pharmaceutical Company Medicament dry powder inhaler dispensing device
MXPA01008849A (es) * 1999-03-03 2003-07-21 Optinose As Dispositivo de administracion nasal.
EP1169244B1 (de) * 1999-03-12 2005-11-02 Glaxo Group Limited Dossierventil
US6223744B1 (en) 1999-03-16 2001-05-01 Multi-Vet Ltd. Wearable aerosol delivery apparatus
US6923979B2 (en) * 1999-04-27 2005-08-02 Microdose Technologies, Inc. Method for depositing particles onto a substrate using an alternating electric field
SE516826C2 (sv) * 1999-06-18 2002-03-05 Shl Medical Ab Anordning i en inhalator med organ för aktivering och avaktivering av en kanister som svar på ett luftflöde
US9006175B2 (en) 1999-06-29 2015-04-14 Mannkind Corporation Potentiation of glucose elimination
US6606992B1 (en) * 1999-06-30 2003-08-19 Nektar Therapeutics Systems and methods for aerosolizing pharmaceutical formulations
US6576224B1 (en) * 1999-07-06 2003-06-10 Sinuspharma, Inc. Aerosolized anti-infectives, anti-inflammatories, and decongestants for the treatment of sinusitis
US20020061281A1 (en) * 1999-07-06 2002-05-23 Osbakken Robert S. Aerosolized anti-infectives, anti-inflammatories, and decongestants for the treatment of sinusitis
US7464706B2 (en) 1999-07-23 2008-12-16 Mannkind Corporation Unit dose cartridge and dry powder inhaler
US7305986B1 (en) 1999-07-23 2007-12-11 Mannkind Corporation Unit dose capsules for use in a dry powder inhaler
US6428809B1 (en) 1999-08-18 2002-08-06 Microdose Technologies, Inc. Metering and packaging of controlled release medication
SE517806C2 (sv) * 1999-11-11 2002-07-16 Microdrug Ag Doseringsanordning för inhalator
AR026914A1 (es) * 1999-12-11 2003-03-05 Glaxo Group Ltd Distribuidor de medicamento
WO2001041846A1 (en) * 1999-12-11 2001-06-14 Glaxo Group Limited Medicament dispenser
GB9929486D0 (en) 1999-12-15 2000-02-09 Glaxo Group Ltd Inhalation delivery apparatus and method
US7080642B2 (en) * 1999-12-22 2006-07-25 3M Innovative Properties Company Refillable device with counting means
GB0003197D0 (en) * 2000-02-11 2000-04-05 Aid Medic Ltd Improvements in and relating to controlling drug delivery
US6971383B2 (en) * 2001-01-24 2005-12-06 University Of North Carolina At Chapel Hill Dry powder inhaler devices, multi-dose dry powder drug packages, control systems, and associated methods
FI20000810A0 (fi) * 2000-04-06 2000-04-06 Orion Yhtymae Oyj Jauheinhalaattori
US6748944B1 (en) * 2000-05-03 2004-06-15 Dellavecchia Michael Anthony Ultrasonic dosage device and method
WO2001087390A2 (en) 2000-05-12 2001-11-22 Iep Pharmaceutical Devices Inc. Powder/liquid metering valve
GB0015034D0 (en) * 2000-06-21 2000-08-09 Glaxo Group Ltd Inhalation device
DK2292287T3 (en) * 2000-07-24 2015-09-14 Clinical Designs Ltd DISPENSER
DE10040528A1 (de) * 2000-08-18 2002-02-28 Pari Gmbh Inhalationsvorrichtung und Verfahren zur Erzeugung eines Partikelnebels für Inhalationszwecke
AUPR020400A0 (en) * 2000-09-19 2000-10-12 Glaxo Wellcome Australia Ltd Inhalation device
SE517225C2 (sv) * 2000-09-21 2002-05-14 Microdrug Ag Optimering av en elektrostatiskt doserad inhalator för torrt pulver
SE517228C2 (sv) * 2000-09-25 2002-05-14 Microdrug Ag Inhalator för torrt pulver med andningsaktivering
SE517229C2 (sv) * 2000-09-25 2002-05-14 Microdrug Ag Kontinuerlig inhalator för torrt pulver
GB0025749D0 (en) * 2000-10-20 2000-12-06 Glaxo Group Ltd Inhaler
JP2004512101A (ja) * 2000-10-20 2004-04-22 グラクソ　グループ　リミテッド 吸入器
US7776315B2 (en) * 2000-10-31 2010-08-17 Boehringer Ingelheim Pharma Gmbh & Co. Kg Pharmaceutical compositions based on anticholinergics and additional active ingredients
US20100310477A1 (en) * 2000-11-28 2010-12-09 Boehringer Ingelheim Pharma Gmbh & Co. Kg. Pharmaceutical compositions based on anticholingerics and additional active ingredients
ES2689704T3 (es) * 2000-11-30 2018-11-15 Vectura Limited Partículas para usar en una composición farmacéutica
ES2474199T3 (es) 2000-11-30 2014-07-08 Vectura Limited Composiciones farmacéuticas para inhalaci�n
US8122880B2 (en) * 2000-12-18 2012-02-28 Palo Alto Research Center Incorporated Inhaler that uses focused acoustic waves to deliver a pharmaceutical product
ZA200306564B (en) * 2001-02-26 2004-10-15 Optinose As Nasal devices.
ATE255929T1 (de) 2001-03-05 2003-12-15 Ivo Pera Inhalationsvorrichtung zum dispergieren von in kapseln enthaltenen pulverförmigen medikamente durch den respirationstrakt
WO2002092154A1 (en) 2001-04-26 2002-11-21 New England Pharmaceuticals, Inc. Metered dose delivery device for liquid and powder agents
WO2002089879A1 (en) * 2001-05-10 2002-11-14 Vectura Delivery Devices Limited Inhalers
US6805853B2 (en) * 2001-11-09 2004-10-19 Alexza Molecular Delivery Corporation Delivery of diazepam through an inhalation route
EP1392262A1 (de) * 2001-05-24 2004-03-03 Alexza Molecular Delivery Corporation Verabreichung von arzneimittel-estern durch inhalation
US7458374B2 (en) 2002-05-13 2008-12-02 Alexza Pharmaceuticals, Inc. Method and apparatus for vaporizing a compound
US7645442B2 (en) 2001-05-24 2010-01-12 Alexza Pharmaceuticals, Inc. Rapid-heating drug delivery article and method of use
US20070122353A1 (en) 2001-05-24 2007-05-31 Hale Ron L Drug condensation aerosols and kits
CA2447519C (en) * 2001-05-24 2008-09-16 Alexza Molecular Delivery Corporation Delivery of alprazolam, estazolam, midazolam or triazolam through an inhalation route
US20030051728A1 (en) 2001-06-05 2003-03-20 Lloyd Peter M. Method and device for delivering a physiologically active compound
US20070087048A1 (en) * 2001-05-31 2007-04-19 Abrams Andrew L Oral dosage combination pharmaceutical packaging
US20020189615A1 (en) * 2001-06-13 2002-12-19 Henry Adam S. Inhaler with dose control
US6681768B2 (en) 2001-06-22 2004-01-27 Sofotec Gmbh & Co. Kg Powder formulation disintegrating system and method for dry powder inhalers
US20030168057A1 (en) * 2001-12-14 2003-09-11 Inhale Therapeutic Systems, Inc. Electronically controllable aerosol delivery
GB0204328D0 (en) * 2002-02-25 2002-04-10 Fyne Dynamics Ltd Flow indicator
EP1894591B1 (de) 2002-03-20 2013-06-26 MannKind Corporation Kartusche für eine Inhalationsvorrichtung
HUE033736T2 (en) 2002-03-22 2018-01-29 Clinical Designs Ltd Box assembly
SE524990C2 (sv) * 2002-04-12 2004-11-09 Microdrug Ag Preparation av terapeutiskt torrt pulver samt förfarande för uppdelning och spridning i luft av medicinskt pulver
SE524957C2 (sv) * 2002-04-12 2004-11-02 Microdrug Ag Förfarande för uppdelning och fördelning i luft av torrt pulvermedikament
SE525027C2 (sv) * 2002-04-12 2004-11-16 Microdrug Ag Anordning utgörande en pulverlufthyvel
AU2003226603A1 (en) * 2002-04-19 2003-11-03 Yissum Research Development Company Of The Hebrew University Of Jerusalem Beta-agonist compounds comprising nitric oxide donor groups and reactive oxygen species scavenger groups and their use in the treatment of respiratory disorders
GB0209526D0 (en) * 2002-04-26 2002-06-05 Glaxo Group Ltd Medicament dispenser
GB0209528D0 (en) * 2002-04-26 2002-06-05 Glaxo Group Ltd Medicament dispenser
US6889690B2 (en) 2002-05-10 2005-05-10 Oriel Therapeutics, Inc. Dry powder inhalers, related blister devices, and associated methods of dispensing dry powder substances and fabricating blister packages
US6985798B2 (en) 2002-05-10 2006-01-10 Oriel Therapeutics, Inc. Dry powder dose filling systems and related methods
US7118010B2 (en) * 2002-05-10 2006-10-10 Oriel Therapeutics, Inc. Apparatus, systems and related methods for dispensing and /or evaluating dry powders
US7677411B2 (en) * 2002-05-10 2010-03-16 Oriel Therapeutics, Inc. Apparatus, systems and related methods for processing, dispensing and/or evaluatingl dry powders
US7185651B2 (en) * 2002-06-18 2007-03-06 Nektar Therapeutics Flow regulator for aerosol drug delivery and methods
CN100591378C (zh) * 2002-06-27 2010-02-24 奥里尔治疗公司 干粉剂量装填系统和相关方法
EP1531794B1 (de) * 2002-06-28 2017-05-10 Civitas Therapeutics, Inc. Epinephrin zur inhalation
WO2004037843A2 (en) * 2002-10-25 2004-05-06 Yissum Research Development Company Of The Hebrew University Of Jerusalem Steroid compounds comprising superoxide dismutase mimic groups and nitric oxide donor groups, and their use in the preparation of medicaments
AU2002952683A0 (en) * 2002-11-15 2002-11-28 Commonwealth Scientific And Industrial Research Organisation Apparatus for delivering dry aerosols to the respiratory tract
US20040105818A1 (en) 2002-11-26 2004-06-03 Alexza Molecular Delivery Corporation Diuretic aerosols and methods of making and using them
US7913688B2 (en) 2002-11-27 2011-03-29 Alexza Pharmaceuticals, Inc. Inhalation device for producing a drug aerosol
GB0304000D0 (en) * 2003-02-21 2003-03-26 Clinical Designs Ltd Dispenser
JP2004290592A (ja) * 2003-03-28 2004-10-21 Canon Inc 液滴吐出装置
GB0311570D0 (en) * 2003-05-20 2003-06-25 Optinose As Delivery device and method
JP2007516404A (ja) 2003-05-21 2007-06-21 アレックザ ファーマシューティカルズ， インコーポレイテッド 光学点火されたかまたは電気点火された内蔵式加熱ユニットおよびそれを使用する薬剤供給ユニット
EP1663281B1 (de) 2003-08-29 2013-12-25 Dyax Corp. Poly-pegylierte proteasehemmer
JP2007505136A (ja) * 2003-09-10 2007-03-08 マツプ・フアーマシユーテイカルズ・インコーポレーテツド ジヒドロエルゴタミンを肺吸入により体循環に送達するためのエアゾール製剤
EP1522325B1 (de) * 2003-10-06 2007-06-13 Bang & Olufsen Medicom A/S Inhalator
US7377277B2 (en) * 2003-10-27 2008-05-27 Oriel Therapeutics, Inc. Blister packages with frames and associated methods of fabricating dry powder drug containment systems
US20070277820A1 (en) * 2003-10-27 2007-12-06 Timothy Crowder Blister packages and associated methods of fabricating dry powder drug containment systems
US7451761B2 (en) * 2003-10-27 2008-11-18 Oriel Therapeutics, Inc. Dry powder inhalers, related blister package indexing and opening mechanisms, and associated methods of dispensing dry powder substances
GB0327112D0 (en) * 2003-11-21 2003-12-24 Clincial Designs Ltd Dispenser and reservoir
GB0328859D0 (en) 2003-12-12 2004-01-14 Clinical Designs Ltd Dispenser and counter
US7607435B2 (en) * 2004-01-21 2009-10-27 Battelle Memorial Institute Gas or liquid flow sensor
GB2410192B (en) * 2004-01-23 2005-12-07 Eg Technology Ltd An inhaler
US7624733B2 (en) * 2004-02-09 2009-12-01 Oriel Therapeutics, Inc. Inhalers with extendable/retractable forward member and associated methods of dispensing inhalant substances
WO2005112983A2 (en) * 2004-05-19 2005-12-01 Wyeth Modulation of immunoglobulin production and atopic disorders
US7540286B2 (en) 2004-06-03 2009-06-02 Alexza Pharmaceuticals, Inc. Multiple dose condensation aerosol devices and methods of forming condensation aerosols
WO2006013951A1 (ja) * 2004-08-02 2006-02-09 Canon Kabushiki Kaisha 薬液カートリッジおよび該カートリッジを用いた吸入装置
CN101010305B (zh) 2004-08-20 2010-08-11 曼金德公司 二酮哌嗪合成的催化反应
PL2322180T3 (pl) 2004-08-23 2015-10-30 Mannkind Corp Sole diketopiperazyny do dostarczania leków
CA2616997C (en) 2004-09-13 2014-12-23 Oriel Therapeutics, Inc. Dry powder inhalers that inhibit agglomeration, related devices and methods
US8210171B2 (en) * 2004-09-13 2012-07-03 Oriel Therapeutics, Inc. Tubular dry powder drug containment systems, associated inhalers and methods
GB0425758D0 (en) 2004-11-23 2004-12-22 Vectura Ltd Preparation of pharmaceutical compositions
GB0507100D0 (en) * 2005-04-08 2005-05-11 Team Holdings Uk Ltd Improvements in or relating to inhalers
HUE038814T2 (hu) 2005-05-18 2018-11-28 Horizon Orphan Llc Aeroszolizált fluor-kinolonok és alkalmazásaik
US8524734B2 (en) 2005-05-18 2013-09-03 Mpex Pharmaceuticals, Inc. Aerosolized fluoroquinolones and uses thereof
IL175664A0 (en) * 2006-05-16 2006-09-05 Aespira Ltd Dry-powder inhaler
DK1915397T3 (en) 2005-08-19 2015-04-20 Wyeth Llc Antagonist AGAINST GDF-8 AND USES IN TREATMENT OF ALS AND OTHER GDF-8-ASSOCIATED DISEASES
AU2006283113B2 (en) * 2005-08-25 2011-12-01 Oriel Therapeutics, Inc. Drug containment systems with sticks, related kits, dry powder inhalers and methods
CN104324362B (zh) 2005-09-14 2018-04-24 曼金德公司 以提高活性试剂对结晶微粒表面的亲和力为基础的药物配制方法
US20090151729A1 (en) 2005-11-08 2009-06-18 Resmed Limited Nasal Assembly
US7832397B2 (en) 2005-12-28 2010-11-16 Philip Morris Usa Inc. Aerosol powder delivery device
EP1986722B1 (de) * 2006-01-31 2018-10-24 Oriel Therapeutics, Inc. Trockenpulverinhalatoren mit spiralförmigen verabreichungswegen für mikrokartuschen mit trockenpulver
GB0602980D0 (en) * 2006-02-14 2006-03-29 Optinose As Delivery device and method
SG170003A1 (en) * 2006-02-20 2011-04-29 Boehringer Ingelheim Int Inhaler
GB2433207B (en) * 2006-02-21 2009-01-07 Jianhe Li Active suction actuated inhalers with timing devices
CN104383546B (zh) 2006-02-22 2021-03-02 曼金德公司 用于改善包含二酮哌嗪和活性剂的微粒的药物性质的方法
ES2622493T3 (es) 2006-02-24 2017-07-06 Rigel Pharmaceuticals, Inc. Composiciones y métodos para la inhibición de la ruta de JAK
US8127763B2 (en) * 2006-03-03 2012-03-06 Stc.Unm Dry powder inhaler with aeroelastic dispersion mechanism
GB0605723D0 (en) * 2006-03-23 2006-05-03 3M Innovative Properties Co Powder filling processes
EP2001537B1 (de) * 2006-04-05 2011-02-09 MicroDose Therapeutx, Inc. Inhalationsvorrichtung für variable dosierung
WO2008008281A2 (en) 2006-07-07 2008-01-17 Proteus Biomedical, Inc. Smart parenteral administration system
FR2904228B1 (fr) * 2006-07-25 2009-05-29 Valois Sas Dispositif de distribution de produit fluide.
FR2904229B1 (fr) * 2006-07-25 2008-10-10 Valois Sas Dispositif de distribution de produit fluide.
DE102006044756A1 (de) * 2006-09-20 2008-04-10 Boehringer Ingelheim Pharma Gmbh & Co. Kg Inhalator
DE102006044755A1 (de) * 2006-09-20 2008-04-10 Boehringer Ingelheim Pharma Gmbh & Co. Kg Inhalator
US20100139655A1 (en) * 2006-11-19 2010-06-10 Aespironics Ltd Dry-powder inhaler
FR2909643B1 (fr) * 2006-12-11 2011-03-04 Valois Sas Dispositif de distribution de produit fluide
ES2538082T3 (es) * 2007-02-11 2015-06-17 Map Pharmaceuticals Inc Método de administración terapéutica de DHE para permitir el rápido alivio de migraña mientras que se minimiza el perfil de efectos secundarios
WO2008112661A2 (en) 2007-03-09 2008-09-18 Alexza Pharmaceuticals, Inc. Heating unit for use in a drug delivery device
EP2011535A1 (de) * 2007-07-06 2009-01-07 Boehringer Ingelheim Pharma GmbH & Co. KG Inhalator
US11224704B2 (en) * 2007-07-06 2022-01-18 Manta Devices, Llc Dose delivery device for inhalation
US8261738B2 (en) * 2007-07-24 2012-09-11 Respironics Respiratory Drug Delivery (Uk) Ltd. Apparatus and method for maintaining consistency for aerosol drug delivery treatments
US20090087483A1 (en) * 2007-09-27 2009-04-02 Sison Raymundo A Oral dosage combination pharmaceutical packaging
WO2009046215A2 (en) * 2007-10-02 2009-04-09 Lab International Srl Safety and abuse deterrent improved device
US8439033B2 (en) 2007-10-09 2013-05-14 Microdose Therapeutx, Inc. Inhalation device
WO2011163272A1 (en) 2010-06-21 2011-12-29 Mannkind Corporation Dry powder drug delivery system and methods
WO2009055733A1 (en) 2007-10-25 2009-04-30 Proteus Biomedical, Inc. Fluid transfer port information system
PE20091163A1 (es) 2007-11-01 2009-08-09 Wyeth Corp Anticuerpos para gdf8
WO2009067463A1 (en) 2007-11-19 2009-05-28 Proteus Biomedical, Inc. Body-associated fluid transport structure evaluation devices
WO2009079078A1 (en) 2007-12-14 2009-06-25 Labogroup S.A.S. Delivering aerosolizable food products
RU2491103C2 (ru) * 2008-03-27 2013-08-27 Маннкайнд Корпорейшн Ингаляционная система для сухого порошка
FR2930164B1 (fr) * 2008-04-16 2011-10-07 Valois Sas Dispositif de distribution de produit fluide.
IL191190A0 (en) * 2008-05-01 2009-08-03 Dan Adler Dry powder inhaler
DK2293833T3 (en) 2008-06-13 2016-05-23 Mannkind Corp DRY POWDER INHALER AND MEDICINAL ADMINISTRATION SYSTEM
US8485180B2 (en) 2008-06-13 2013-07-16 Mannkind Corporation Dry powder drug delivery system
KR101628410B1 (ko) 2008-06-20 2016-06-08 맨카인드 코포레이션 흡입 활동에 관한 실시간 프로파일링을 위한 대화형 장치 및 방법
TWI494123B (zh) 2008-08-11 2015-08-01 Mannkind Corp 超快起作用胰島素之用途
US20100143349A1 (en) * 2008-08-12 2010-06-10 Wyeth Humanized anti-rage antibody
CA2739893C (en) 2008-10-07 2016-10-04 Mpex Pharmaceuticals, Inc. Inhalation of levofloxacin for reducing lung inflammation
KR20110091510A (ko) 2008-10-07 2011-08-11 엠펙스 파마슈티컬즈, 인코포레이티드 약동학 개선을 위한 에어로졸 플루오로퀴놀론 제형
GB201020130D0 (en) * 2010-11-26 2011-01-12 Vectura Delivery Devices Ltd Inhaler
US8314106B2 (en) 2008-12-29 2012-11-20 Mannkind Corporation Substituted diketopiperazine analogs for use as drug delivery agents
US10387621B2 (en) 2009-01-16 2019-08-20 Cerner Innovation, Inc. Matching of vibratory inhalers to patient vocal tract for optimization of particle dispersion
DK2389372T3 (en) 2009-01-23 2015-12-14 Rigel Pharmaceuticals Inc COMPOSITIONS AND METHODS FOR INHIBITION OF JAK pathway
US9925282B2 (en) 2009-01-29 2018-03-27 The General Hospital Corporation Cromolyn derivatives and related methods of imaging and treatment
DK2405963T3 (da) 2009-03-11 2013-12-16 Mannkind Corp Apparat, system og fremgangsmåde til at måle modstand i en inhalator
EP2432535B1 (de) * 2009-05-18 2017-09-20 Adamis Pharmaceuticals Corporation Trockenpulverinhalatoren
EP2432534B1 (de) 2009-05-18 2018-01-17 Adamis Pharmaceuticals Corporation Dosiszähler für einen trockenpulverinhalator
BRPI1013154B1 (pt) 2009-06-12 2020-04-07 Mannkind Corp Micropartículas de dicetopiperazina com áreas de superfície específicas definidas, pó seco compreendendo as referidas micropartículas, método para formação das referidasmicropartículas e formação de micropartículas de fumaril diacetopiperazina, uso das referidas micropartículas e sistema de inalação
WO2010151804A1 (en) * 2009-06-26 2010-12-29 Map Pharmaceuticals, Inc. Administration of dihydroergotamine mesylate particles using a metered dose inhaler
WO2011031564A2 (en) * 2009-08-27 2011-03-17 Stc.Unm Methods and systems for dosing and coating inhalation powders onto carrier particles
PL2473170T3 (pl) 2009-09-04 2020-03-31 Horizon Orphan Llc Zastosowanie lewofloksacyny w aerozolu do leczenia mukowiscydozy
EP2496295A1 (de) 2009-11-03 2012-09-12 MannKind Corporation Vorrichtung und verfahren zur simulation von einatmungsanstrengungen
US9492625B2 (en) 2009-11-12 2016-11-15 Stc.Unm Dry powder inhaler with flutter dispersion member
WO2011077414A2 (en) 2009-12-26 2011-06-30 D.P.I Advanced Medical Technologies Ltd. Dry powder delivery device
TWI589313B (zh) 2010-01-05 2017-07-01 麥可朵斯斯若波特公司 醫藥遞送封裝及吸入器
EP2528601A1 (de) 2010-01-26 2012-12-05 Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. Zusammensetzungen und verfahren zur prävention und behandlung von lungenhochdruck
CN102905612A (zh) 2010-02-01 2013-01-30 普罗秋斯数字健康公司 双腕式数据采集系统
EP2531099B1 (de) 2010-02-01 2018-12-12 Proteus Digital Health, Inc. Datensammelsystem
JP2013529124A (ja) * 2010-03-09 2013-07-18 エスティーシー． ユーエヌエム 表面を微小粒子でドライコーティングする装置および方法
FR2962343B1 (fr) * 2010-07-07 2012-08-03 Valois Sas Inhalateur de poudre seche.
ES2646748T3 (es) 2010-12-07 2017-12-15 Respira Therapeutics, Inc. Inhalador de polvo seco
EP4059499A1 (de) 2011-01-31 2022-09-21 Avalyn Pharma Inc. Aerosolförmige pirfenidon- und pyridonanalogverbindungen und verwendungen davon
SG194034A1 (en) 2011-04-01 2013-11-29 Mannkind Corp Blister package for pharmaceutical cartridges
US8834411B2 (en) * 2011-04-06 2014-09-16 Mystic Pharmaceuticals, Inc. Medical devices for dispensing powders
WO2012174472A1 (en) 2011-06-17 2012-12-20 Mannkind Corporation High capacity diketopiperazine microparticles
AU2012328885B2 (en) 2011-10-24 2017-08-31 Mannkind Corporation Methods and compositions for treating pain
US10525216B2 (en) 2012-02-21 2020-01-07 Respira Therapeutics, Inc. Powder dispersion methods and devices
US10463815B2 (en) 2012-02-21 2019-11-05 Respira Therapeutics, Inc. Inhaler to deliver substances for prophylaxis or prevention of disease or injury caused by the inhalation of biological or chemical agents
US8877967B2 (en) 2012-03-23 2014-11-04 Oxigene, Inc. Compositions and methods for inhibition of cathepsins
WO2013186719A1 (en) 2012-06-15 2013-12-19 Pfizer Inc. Improved antagonist antibodies against gdf-8 and uses therefor
CN108057154B (zh) 2012-07-12 2021-04-16 曼金德公司 干粉药物输送系统和方法
CA2879340C (en) 2012-07-19 2020-04-07 Adamis Pharmaceuticals Corporation Powder feeding apparatus
CN109846862A (zh) 2012-10-25 2019-06-07 通用医疗公司 治疗阿尔茨海默病及相关疾病的组合疗法
US10058530B2 (en) 2012-10-25 2018-08-28 The General Hospital Corporation Combination therapies for the treatment of Alzheimer's disease and related disorders
WO2014066856A1 (en) 2012-10-26 2014-05-01 Mannkind Corporation Inhalable influenza vaccine compositions and methods
ES2928365T3 (es) 2013-03-15 2022-11-17 Mannkind Corp Composiciones de dicetopiperazina microcristalina, métodos de preparación y uso del mismo
US10525005B2 (en) 2013-05-23 2020-01-07 The General Hospital Corporation Cromolyn compositions and methods thereof
JP2016534976A (ja) * 2013-05-23 2016-11-10 アズセラピーズ インコーポレイテッド クロモリンを送達する方法
EP3021834A1 (de) 2013-07-18 2016-05-25 MannKind Corporation Hitzestabile pharmazeutische trockenpulverzusammensetzungen und verfahren
CA3172586A1 (en) 2013-07-31 2015-02-05 Avalyn Pharma Inc. Aerosol imatininb compounds and uses thereof
CN105517607A (zh) 2013-08-05 2016-04-20 曼金德公司 吹入设备和方法
EP3041555A4 (de) 2013-09-04 2017-03-08 3M Innovative Properties Company Trockenpulverinhalator und verfahren
JP2016534063A (ja) 2013-10-22 2016-11-04 ザ ジェネラル ホスピタル コーポレイション クロモリン誘導体ならびに関連するイメージングおよび治療方法
AU2015204558B2 (en) 2014-01-10 2020-04-30 Avalyn Pharma Inc. Aerosol pirfenidone and pyridone analog compounds and uses thereof
NO2709641T3 (de) 2014-03-10 2018-05-12
US10307464B2 (en) 2014-03-28 2019-06-04 Mannkind Corporation Use of ultrarapid acting insulin
WO2016033419A1 (en) 2014-08-28 2016-03-03 Microdose Therapeutx, Inc. Compliance monitoring module for a breath-actuated inhaler
US10561806B2 (en) 2014-10-02 2020-02-18 Mannkind Corporation Mouthpiece cover for an inhaler
DE102014116694A1 (de) * 2014-11-14 2016-05-19 Bluestone Technology GmbH Verfahren und Vorrichtung zur kontrollierten Abgabe von Partikeln
CN106031809A (zh) * 2015-03-12 2016-10-19 昆山科技大学 药雾吸入辅助器结构
EP3307060B1 (de) * 2015-06-14 2023-03-08 Tobe Influence Innovation Ltd. Vorrichtung zur ungezieferbekämpfung von bienenstöcken und verfahren zu deren kontrolle
TR201900331T4 (tr) * 2015-06-29 2019-02-21 Philip Morris Products Sa Bir aerosol - üretici sistem için kartuş.
KR102641177B1 (ko) 2015-07-20 2024-02-26 펄 테라퓨틱스 인코포레이티드 에어로졸 전달 시스템 및 관련 방법
US10688260B2 (en) 2015-09-24 2020-06-23 Mystic Pharmaceuticals, Inc. Devices and systems for air assisted dry powder administration
WO2017079397A1 (en) * 2015-11-05 2017-05-11 Otitopic Inc. Dry powder inhalation device
CA3019203A1 (en) * 2016-03-24 2017-09-28 Trudell Medical International Respiratory care system with electronic indicator
CN109475711B (zh) 2016-05-19 2022-04-15 曼金德公司 用于检测和监控吸入的装置、系统和方法
KR20190044647A (ko) 2016-08-31 2019-04-30 더 제너럴 하스피탈 코포레이션 신경변성 질환과 관련된 신경-염증에서 대식세포/미세아교세포
CN107890598B (zh) * 2016-10-03 2020-10-27 捷普科技（上海）有限公司 药剂分配器
GB201706505D0 (en) 2017-04-25 2017-06-07 3M Innovative Properties Co Medicinal inhaler drive mechanism
US20210100965A1 (en) * 2017-05-26 2021-04-08 Microdose Therapeutx, Inc. Inhaler with synthetic jetting
CN107233659B (zh) * 2017-05-31 2020-05-19 麦递途医疗科技（上海）有限公司 一种占位给药装置
CN110603067B (zh) 2017-05-31 2022-04-05 菲利普莫里斯生产公司 带有阻塞气流元件的吸入器制品
KR20210070232A (ko) 2017-07-20 2021-06-14 아즈테라피즈 인코포레이티드 크로몰린 나트륨 및 이부프로펜의 분말화된 제형
CA3105392A1 (en) 2018-07-02 2020-01-09 The General Hospital Corporation Powdered formulations of cromolyn sodium and .alpha.-lactose
US20220000880A1 (en) 2018-11-01 2022-01-06 Rigel Pharmaceuticals, Inc. Method and composition embodiments for treating acute myeloid leukemia
US20200377518A1 (en) 2019-05-29 2020-12-03 Rigel Pharmaceuticals, Inc. Method of preventing and treating thrombosis
CA3147443A1 (en) 2019-08-08 2021-02-11 Rigel Pharmaceuticals, Inc. Compounds and method for treating cytokine release syndrome
MX2022001890A (es) 2019-08-14 2022-04-26 Rigel Pharmaceuticals Inc Metodo para bloquear o mejorar el sindrome de liberacion de citocinas.
US11911558B2 (en) 2019-09-03 2024-02-27 Trudell Medical International Medical device with energy harvesting system
WO2022240897A1 (en) 2021-05-10 2022-11-17 Sepelo Therapeutics, Llc Pharmaceutical composition comprising delafloxacin for administration into the lung
CN113456468A (zh) * 2021-06-01 2021-10-01 高会莉 一种基于中药雾化的妇科臭氧治疗装置
WO2023028364A1 (en) 2021-08-27 2023-03-02 Sepelo Therapeutics, Llc Targeted compositions and uses therof
WO2023183377A1 (en) 2022-03-23 2023-09-28 Rigel Pharmaceuticals, Inc. Pyrimid-2-yl-pyrazole compounds as irak inhibitors
CN117258088B (zh) * 2023-11-14 2024-01-16 佛山市南海区第五人民医院(佛山市南海区大沥医院) 一种用于儿科肺炎雾化吸入治疗设备

Family Cites Families (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB898649A (en) 1958-05-06 1962-06-14 Benger Lab Ltd Improvements in and relating to the application of finely divided material
US3187748A (en) * 1963-04-29 1965-06-08 Merck And Company Inc Inhalation-actuated aerosol device
US3456646A (en) * 1967-01-19 1969-07-22 Dart Ind Inc Inhalation-actuated aerosol dispensing device
US3456645A (en) * 1967-01-19 1969-07-22 Dart Ind Inc Inhalation-actuated aerosol dispensing device
US3456644A (en) * 1967-01-19 1969-07-22 Dart Ind Inc Inhalation-actuated aerosol dispensing device
US3565070A (en) * 1969-02-28 1971-02-23 Riker Laboratories Inc Inhalation actuable aerosol dispenser
US3636949A (en) * 1969-08-08 1972-01-25 Armstrong Kropp Dev Corp Inhalation-initiated aerosol dispenser
BE758834A (fr) * 1969-11-13 1971-05-12 Riker Laboratoires Inc Distributeur d'aerosol actionne par inhalation
GB1383761A (en) * 1971-02-25 1974-02-12 Woodcraft Dc Inhalation device for use with an aerosol container
US3732864A (en) * 1971-06-07 1973-05-15 Schering Corp Inhalation coordinated aerosol dispensing device
NO134730L (de) * 1971-07-19 1900-01-01
GB1413285A (en) * 1971-11-25 1975-11-12 Bespak Industries Ltd Aerosol devices
US3777742A (en) * 1972-09-18 1973-12-11 Barber Colman Co Tantalum insufflator
GB1479283A (en) 1973-07-23 1977-07-13 Bespak Industries Ltd Inhaler for powdered medicament
US3971377A (en) 1974-06-10 1976-07-27 Alza Corporation Medicament dispensing process for inhalation therapy
US3915165A (en) * 1974-09-13 1975-10-28 Minnesota Mining & Mfg Intratracheal injection system for animals
US3948264A (en) 1975-05-21 1976-04-06 Mead Johnson & Company Inhalation device
US4109656A (en) * 1977-02-07 1978-08-29 Sybron Corporation Apparatus for use with insufflators
US4147166A (en) 1977-05-02 1979-04-03 American Cyanamid Company Oral inhalator powder dispenser
DE2831553A1 (de) * 1978-07-18 1980-01-31 Siemens Ag Verfahren zur ultraschall-fluessigkeitszerstaeubung
DE2837040C2 (de) * 1978-08-24 1982-10-21 Siemens AG, 1000 Berlin und 8000 München Flüssigkeitstransportsystem für ein Inhalationsgerät
GB2061735B (en) * 1979-10-30 1983-11-30 Riker Laboratories Inc Breath actuated device for administration of powdered medicaments by inhalation
WO1981001243A1 (en) * 1979-10-30 1981-05-14 Riker Laboratories Inc Breath actuated devices for administering powdered medicaments
DE3166709D1 (en) * 1980-08-04 1984-11-22 Fisons Plc Inhalation device for administering medicaments
DE3037917A1 (de) * 1980-10-08 1982-05-13 Byk Gulden Lomberg Chemische Fabrik Gmbh, 7750 Konstanz Inhaliergeraet
DE3040641A1 (de) * 1980-10-29 1982-05-27 C.H. Boehringer Sohn, 6507 Ingelheim Mundrohr fuer dosieraerosol-geraete
SE438261B (sv) * 1981-07-08 1985-04-15 Draco Ab Anvendning i dosinhalator av ett perforerat membran
CY1492A (en) * 1981-07-08 1990-02-16 Draco Ab Powder inhalator
JPS5876038A (ja) * 1981-10-28 1983-05-09 高森　正之 殺虫剤や芳香剤の蒸発装置
FR2516387A1 (fr) * 1981-11-16 1983-05-20 Fabre Sa Pierre Inhalateur liberant des quantites pre-dosees de principe actif volatil ou entrainable par un excipient volatil contenu dans des microcapsules reparties periodiquement sur un support, ainsi que ledit support et son procede de fabrication
GB2122903B (en) * 1982-06-22 1986-11-05 Masayuki Takamori Vaporizers for vaporisable substances and support media for substances usable therewith
US4576157A (en) * 1983-10-24 1986-03-18 Raghuprasad Puthalath K Oral inhalation apparatus
GB8328808D0 (en) * 1983-10-28 1983-11-30 Riker Laboratories Inc Inhalation responsive dispensers
US4648393A (en) * 1984-11-02 1987-03-10 Ackrad Laboratories, Inc. Breath activated medication spray
US4592348A (en) * 1984-12-17 1986-06-03 Waters Iv William C Aerosol inhaler
US4712460A (en) * 1985-11-18 1987-12-15 Biotrack, Inc. Integrated drug dosage form and metering system
JPS62204756A (ja) * 1986-03-04 1987-09-09 大研医工株式会社 薬剤揮散方法および装置
FR2598918B1 (fr) * 1986-05-23 1988-08-05 Lille Ii Universite Droit Sant Dispositif permettant l'insufflation dans les voies respiratoires d'une poudre radio-opaque a l'etat finement divise
US5031610A (en) * 1987-05-12 1991-07-16 Glaxo Inc. Inhalation device
BR8802287A (pt) * 1987-05-12 1988-12-13 Glaxo Inc Aparelho de inalacao
US5119806A (en) * 1987-05-12 1992-06-09 Glaxo Inc. Inhalation device
DK479189D0 (da) * 1989-01-06 1989-09-28 Hans Gernot Schenk Inhalator
EP0470154B1 (de) * 1989-04-28 1996-06-05 Riker Laboratories, Inc. Inhalationsvorrichtung für trockenpulver
GB8909891D0 (en) * 1989-04-28 1989-06-14 Riker Laboratories Inc Device
GB8919131D0 (en) * 1989-08-23 1989-10-04 Riker Laboratories Inc Inhaler
US5113855A (en) * 1990-02-14 1992-05-19 Newhouse Michael T Powder inhaler
US5060643A (en) * 1990-08-07 1991-10-29 Tenax Corporation Breath-activated inhalation device
DE4027390C2 (de) * 1990-08-30 1994-11-03 Boehringer Ingelheim Kg Treibgasfreies Inhalationsgerät
DE4027391A1 (de) * 1990-08-30 1992-03-12 Boehringer Ingelheim Kg Treibgasfreies inhalationsgeraet
US5507281A (en) * 1990-08-30 1996-04-16 Boehringer Ingelheim Kg Device for initiating a mechanical switching operation in synchronism with the breathing
FR2667509B1 (fr) * 1990-10-04 1995-08-25 Valois Inhalateur a poudre, dispositif de conditionnement de microdoses de poudre sous forme de bandes adaptees a etre utilisees dans un inhalateur a poudre, et procede de fabrication de ces bandes.
US5027808A (en) * 1990-10-31 1991-07-02 Tenax Corporation Breath-activated inhalation device
US5327883A (en) * 1991-05-20 1994-07-12 Dura Pharmaceuticals, Inc. Apparatus for aerosolizing powdered medicine and process and using
FR2700279B1 (fr) * 1993-01-14 1995-03-17 Valois Dispositif portatif pour projeter des doses d'une substance fluide à l'aide d'un flux d'air comprimé.
FR2718968B1 (fr) * 1994-04-20 1996-07-26 Valois Sa Insert délimitant une chambre de dosage d'un inhalateur.
FR2738153B1 (fr) * 1995-09-04 1998-01-02 Valois Appareil d'inhalation destine a distribuer des doses precises et reproductibles de produit pulverulent

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19956260A1 (de) * 1999-11-23 2001-05-31 Inamed Gmbh Abscheidevorrichtung, insbesondere für Trockenpulvermedikamente in Aerosolform

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ATE224748T1 (de) 2002-10-15
WO1990013327A1 (en) 1990-11-15
US5655523A (en) 1997-08-12
EP0470154B1 (de) 1996-06-05
AU643435B2 (en) 1993-11-18
AU5539590A (en) 1990-11-29
DK0470154T3 (da) 1996-10-21
DE69034007T2 (de) 2003-05-08
ES2087911T3 (es) 1996-08-01
JPH05501505A (ja) 1993-03-25
ATE138814T1 (de) 1996-06-15
CA2058764A1 (en) 1990-10-29
EP0705614B1 (de) 2002-09-25
DE69034007D1 (de) 2002-10-31
US6012454A (en) 2000-01-11
EP0470154A1 (de) 1992-02-12
DE69027319D1 (de) 1996-07-11
EP0705614A1 (de) 1996-04-10

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