DE69112384T2 - Triarylmethyl-radikale und die anwendung von inerten kohlenstofffreien radikalen in mri. - Google Patents

Triarylmethyl-radikale und die anwendung von inerten kohlenstofffreien radikalen in mri.

Info

Publication number
DE69112384T2
DE69112384T2 DE69112384T DE69112384T DE69112384T2 DE 69112384 T2 DE69112384 T2 DE 69112384T2 DE 69112384 T DE69112384 T DE 69112384T DE 69112384 T DE69112384 T DE 69112384T DE 69112384 T2 DE69112384 T2 DE 69112384T2
Authority
DE
Germany
Prior art keywords
radicals
sample
mri
free radical
inert carbon
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69112384T
Other languages
English (en)
Other versions
DE69112384D1 (de
Inventor
Mikkel Jorgensen
Frode Rise
Sven Andersson
Torsten Almen
Arne Aabye
Lars-Goeran Wistrand
Hakan Wikstroem
Klaes Golman
Rolf Servin
Peter Michelsen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GE Healthcare AS
Original Assignee
Nycomed Innovation AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB909003105A external-priority patent/GB9003105D0/en
Priority claimed from GB909012300A external-priority patent/GB9012300D0/en
Application filed by Nycomed Innovation AB filed Critical Nycomed Innovation AB
Publication of DE69112384D1 publication Critical patent/DE69112384D1/de
Application granted granted Critical
Publication of DE69112384T2 publication Critical patent/DE69112384T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/20—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations containing free radicals, e.g. trityl radical for overhauser
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/16—Radicals substituted by singly bound hetero atoms other than halogen by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
DE69112384T 1990-02-12 1991-02-12 Triarylmethyl-radikale und die anwendung von inerten kohlenstofffreien radikalen in mri. Expired - Lifetime DE69112384T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB909003105A GB9003105D0 (en) 1990-02-12 1990-02-12 Compositions
GB909012300A GB9012300D0 (en) 1990-06-01 1990-06-01 Compositions
PCT/EP1991/000285 WO1991012024A1 (en) 1990-02-12 1991-02-12 Triarylmethyl radicals and the use of inert carbon free radicals in mri

Publications (2)

Publication Number Publication Date
DE69112384D1 DE69112384D1 (de) 1995-09-28
DE69112384T2 true DE69112384T2 (de) 1996-03-28

Family

ID=26296651

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69112384T Expired - Lifetime DE69112384T2 (de) 1990-02-12 1991-02-12 Triarylmethyl-radikale und die anwendung von inerten kohlenstofffreien radikalen in mri.

Country Status (14)

Country Link
US (2) US5599522A (de)
EP (1) EP0515458B1 (de)
JP (1) JP3175940B2 (de)
AT (1) ATE126707T1 (de)
AU (1) AU651570B2 (de)
CA (1) CA2075818A1 (de)
DE (1) DE69112384T2 (de)
DK (1) DK0515458T3 (de)
ES (1) ES2076522T3 (de)
FI (1) FI923589A (de)
GR (1) GR3017947T3 (de)
IE (1) IE69365B1 (de)
NO (1) NO923117L (de)
WO (1) WO1991012024A1 (de)

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EP0662004B1 (de) * 1991-08-09 1998-03-18 Nycomed Innovation AB Verwendung von dauerhafte frei radikalen zur bilderzeugung mittels magnetischer resonanz
GB9117258D0 (en) * 1991-08-09 1991-09-25 Hafslund Nycomed Innovation Use of radicals
US5728370A (en) * 1993-04-02 1998-03-17 Nycomed Imaging As Free Radicals
GB9307027D0 (en) * 1993-04-02 1993-05-26 Nycomed Innovation Ab Free radicals
GB9704669D0 (en) * 1997-03-06 1997-04-23 Nycomed Imaging As Free radicals
WO1998022148A1 (en) * 1996-11-20 1998-05-28 Washington University Mri contrast agents and ligands
US6278893B1 (en) 1998-01-05 2001-08-21 Nycomed Imaging As Method of magnetic resonance imaging of a sample with ex vivo polarization of an MR imaging agent
DE10029075A1 (de) * 2000-06-13 2001-12-20 Bayer Ag Verfahren zur Herstellung von 3,4-Alkylendioxythiophen-2,5-dicarbonsäurederivaten
NL1017122C2 (nl) * 2001-01-16 2002-07-17 Doornes Transmissie Bv Dwarselement voor een drijfriem voor een continu variabele transmissie.
US7126332B2 (en) * 2001-07-20 2006-10-24 Baker Hughes Incorporated Downhole high resolution NMR spectroscopy with polarization enhancement
NO20031736D0 (no) * 2003-04-15 2003-04-15 Amersham Health As Forbindelser
DK1797102T3 (en) 2004-07-30 2015-08-24 Ge Healthcare As A composition comprising triarylmethylradikal that can be used for MRI diagnosis
KR101554832B1 (ko) * 2004-07-30 2015-09-21 지이 헬스케어 에이에스 라디칼 및 동적 핵 편극화 공정에서 상자성 물질로서의 그의 용도
JP2009510081A (ja) * 2005-09-28 2009-03-12 プレジデント アンド フェローズ オブ ハーバード カレッジ 磁気共鳴イメージングにおける造影剤としての使用のための長いスピン緩和時間を有する過分極化された固形物
NO20055681D0 (no) * 2005-12-01 2005-12-01 Amersham Health As Method of dynamic nuclear polarisation
PL1954321T3 (pl) 2005-12-01 2012-04-30 Ge Healthcare As Sposób dynamicznej polaryzacji jądrowej (DNP) przy użyciu rodnika tritylowego oraz jonu metalu paramagnetycznego
EP1960001A2 (de) 2005-12-08 2008-08-27 Koninklijke Philips Electronics N.V. System und verfahren zur überwachung einer in-vivo-wirkstofffreisetzung über overhauser-erweiterte kernspinresonanz
EP1968442A4 (de) * 2005-12-10 2009-11-04 Harvard College In-situ-hyperpolarisation von bildgebungsmitteln
ES2393750T3 (es) 2005-12-16 2012-12-27 Ge Healthcare As Procedimiento para producir carbosilatos hiperpolarizados de aminas orgánicas
EP1984757A4 (de) * 2006-01-11 2009-11-04 Harvard College Ex-vivo-hyperpolarisation von abbildungsmitteln
US8703102B2 (en) 2008-04-04 2014-04-22 Millikelvin Technologies Llc Systems and methods for producing hyperpolarized materials and mixtures thereof
AU2007254464B2 (en) 2006-02-21 2013-02-21 Avrum Belzer Hyperpolarization methods, systems and compositions
WO2007111515A2 (en) * 2006-03-29 2007-10-04 Ge Healthcare As Method to produce hyperpolarised carboxylates and sulphonates
JP5269791B2 (ja) 2006-08-30 2013-08-21 ジーイー・ヘルスケア・アクスイェ・セルスカプ 動的核分極（ｄｎｐ）方法並びに該方法で使用するための化合物及び組成物
EP2135911B1 (de) 2007-03-30 2014-05-28 FUJIFILM Corporation Ultraviolettstrahlenabsorbierende zusammensetzung
WO2009022736A1 (ja) 2007-08-16 2009-02-19 Fujifilm Corporation ヘテロ環化合物、紫外線吸収剤及びこれを含む組成物
EP2902041A1 (de) 2007-12-19 2015-08-05 GE Healthcare Limited Zusammensetzung und Verfahren zur Erzeugung eines metabolischen Profils bei Verwendung von 13C-MR
JP2010059235A (ja) 2008-09-01 2010-03-18 Fujifilm Corp 紫外線吸収剤組成物
US20100092390A1 (en) * 2008-10-09 2010-04-15 President And Fellows Of Harvard College Methods for Making Particles Having Long Spin-Lattice Relaxation Times
US8697034B2 (en) 2008-10-10 2014-04-15 The Board Of Regents Of The University Of Texas System Hyperpolarized 89-yttrium and methods relating thereto
EP2476009A1 (de) 2009-09-10 2012-07-18 GE Healthcare UK Limited 13c-mr-detektion mit hyperpolarisierter 13-c-fructose
US8593141B1 (en) 2009-11-24 2013-11-26 Hypres, Inc. Magnetic resonance system and method employing a digital squid
CN102892434B (zh) 2010-04-08 2014-11-19 伯拉考成像股份公司 制备超极化底物的方法和mri方法
US8970217B1 (en) 2010-04-14 2015-03-03 Hypres, Inc. System and method for noise reduction in magnetic resonance imaging
EP2399913B1 (de) * 2010-06-25 2013-09-18 Universität Potsdam Fluoreszenzfarbstoff und seine Verwendung
FR2967158A1 (fr) 2010-11-08 2012-05-11 Phosphoenix Sarl Nouveaux radicaux triarylmethyle: leur preparation et application
US9511154B2 (en) 2011-10-12 2016-12-06 Bracco Imaging S.P.A. Process for the preparation of hyperpolarized derivatives for use in MRI analysis
WO2013083535A1 (en) 2011-12-05 2013-06-13 Bracco Imaging Spa Composition comprising acetic anhydride and a gadolinium complex, and method for the use in hyperpolarisation mri analysis
WO2013149935A1 (en) 2012-04-02 2013-10-10 Bracco Imaging Spa Hyperpolarized amino acids
JP6026824B2 (ja) * 2012-09-04 2016-11-16 紀本電子工業株式会社 芳香族ニトロ化合物のラジカルアニオンの製造方法
JP7427354B2 (ja) 2018-01-29 2024-02-05 日清オイリオグループ株式会社 炊飯用油脂組成物、飯類、及び飯類の製造方法

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DE3328365A1 (de) * 1983-08-03 1985-02-21 Schering AG, 1000 Berlin und 4709 Bergkamen Neue diagnostische mittel
ES2026257T3 (es) * 1987-06-23 1992-04-16 Hafslund Nycomed Innovation Ab Mejoras introducidas en la presentacion de imagenes por resonancia magnetica nuclear.
GB8819753D0 (en) * 1988-08-19 1988-09-21 Nycomed As Apparatus

Also Published As

Publication number Publication date
CA2075818A1 (en) 1991-08-13
ATE126707T1 (de) 1995-09-15
IE69365B1 (en) 1996-09-04
GR3017947T3 (en) 1996-02-29
DK0515458T3 (da) 1995-09-25
IE910462A1 (en) 1991-08-14
DE69112384D1 (de) 1995-09-28
ES2076522T3 (es) 1995-11-01
FI923589A0 (fi) 1992-08-11
JPH05506428A (ja) 1993-09-22
AU7235091A (en) 1991-09-03
FI923589A (fi) 1992-08-11
EP0515458A1 (de) 1992-12-02
WO1991012024A1 (en) 1991-08-22
NO923117L (no) 1992-10-08
EP0515458B1 (de) 1995-08-23
US5827501A (en) 1998-10-27
NO923117D0 (no) 1992-08-11
AU651570B2 (en) 1994-07-28
JP3175940B2 (ja) 2001-06-11
US5599522A (en) 1997-02-04

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Legal Events

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8327 Change in the person/name/address of the patent owner

Owner name: GE HEALTHCARE AS, OSLO, NO