DE69123979T2 - Abgeänderte ribozyme - Google Patents

Abgeänderte ribozyme

Info

Publication number
DE69123979T2
DE69123979T2 DE69123979T DE69123979T DE69123979T2 DE 69123979 T2 DE69123979 T2 DE 69123979T2 DE 69123979 T DE69123979 T DE 69123979T DE 69123979 T DE69123979 T DE 69123979T DE 69123979 T2 DE69123979 T2 DE 69123979T2
Authority
DE
Germany
Prior art keywords
modified
ribozyms
amino
rna molecules
modified rna
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69123979T
Other languages
English (en)
Other versions
DE69123979D1 (de
Inventor
Fritz Eckstein
Wolfgang Pieken
Fritz Benseler
David Olsen
David Williams
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Max Planck Gesellschaft zur Foerderung der Wissenschaften eV
Original Assignee
Max Planck Gesellschaft zur Foerderung der Wissenschaften eV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Max Planck Gesellschaft zur Foerderung der Wissenschaften eV filed Critical Max Planck Gesellschaft zur Foerderung der Wissenschaften eV
Application granted granted Critical
Publication of DE69123979D1 publication Critical patent/DE69123979D1/de
Publication of DE69123979T2 publication Critical patent/DE69123979T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1131—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against viruses
    • C12N15/1132—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against viruses against retroviridae, e.g. HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/12—Type of nucleic acid catalytic nucleic acids, e.g. ribozymes
    • C12N2310/121—Hammerhead
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/12—Type of nucleic acid catalytic nucleic acids, e.g. ribozymes
    • C12N2310/122—Hairpin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/315—Phosphorothioates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/322—2'-R Modification
DE69123979T 1990-10-12 1991-09-23 Abgeänderte ribozyme Expired - Fee Related DE69123979T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP9001731 1990-10-12
PCT/EP1991/001811 WO1992007065A1 (en) 1990-10-12 1991-09-23 Modified ribozymes

Publications (2)

Publication Number Publication Date
DE69123979D1 DE69123979D1 (de) 1997-02-13
DE69123979T2 true DE69123979T2 (de) 1997-04-30

Family

ID=8165527

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69123979T Expired - Fee Related DE69123979T2 (de) 1990-10-12 1991-09-23 Abgeänderte ribozyme
DE91916858T Pending DE552178T1 (de) 1990-10-12 1991-09-23 Abgeänderte ribozyme.

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE91916858T Pending DE552178T1 (de) 1990-10-12 1991-09-23 Abgeänderte ribozyme.

Country Status (11)

Country Link
US (3) US5672695A (de)
EP (1) EP0552178B1 (de)
JP (2) JP3257675B2 (de)
AT (1) ATE147098T1 (de)
AU (1) AU649074B2 (de)
CA (1) CA2093664C (de)
DE (2) DE69123979T2 (de)
ES (1) ES2061416T3 (de)
GR (1) GR930300130T1 (de)
PL (1) PL169576B1 (de)
WO (1) WO1992007065A1 (de)

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CA2039718C (en) * 1989-08-31 2003-02-25 John J. Rossi Chimeric dna-rna catalytic sequences
CA2084790C (en) * 1990-06-19 2002-04-09 Philip Anthony Jennings Endonucleases
ATE147098T1 (de) * 1990-10-12 1997-01-15 Max Planck Gesellschaft Abgeänderte ribozyme
DE4216134A1 (de) * 1991-06-20 1992-12-24 Europ Lab Molekularbiolog Synthetische katalytische oligonukleotidstrukturen
US5817635A (en) * 1993-08-09 1998-10-06 Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. Modified ribozymes

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EP0552178B1 (de) 1997-01-02
AU8613991A (en) 1992-05-20
US5672695A (en) 1997-09-30
ES2061416T1 (es) 1994-12-16
US5698687A (en) 1997-12-16
US6890908B1 (en) 2005-05-10
CA2093664C (en) 2003-07-29
CA2093664A1 (en) 1992-04-13
GR930300130T1 (en) 1993-12-30
WO1992007065A1 (en) 1992-04-30
DE552178T1 (de) 1994-02-03
JP3257675B2 (ja) 2002-02-18
ES2061416T3 (es) 1997-03-01
AU649074B2 (en) 1994-05-12
EP0552178A1 (de) 1993-07-28
ATE147098T1 (de) 1997-01-15
JP2002101893A (ja) 2002-04-09
JPH06501842A (ja) 1994-03-03
DE69123979D1 (de) 1997-02-13
PL169576B1 (pl) 1996-08-30

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