DE69132688D1 - Methode zur behandlung und vorbeugung von typ-1 diabetis durch orale verabreichung von insulin - Google Patents

Methode zur behandlung und vorbeugung von typ-1 diabetis durch orale verabreichung von insulin

Info

Publication number
DE69132688D1
DE69132688D1 DE69132688T DE69132688T DE69132688D1 DE 69132688 D1 DE69132688 D1 DE 69132688D1 DE 69132688 T DE69132688 T DE 69132688T DE 69132688 T DE69132688 T DE 69132688T DE 69132688 D1 DE69132688 D1 DE 69132688D1
Authority
DE
Germany
Prior art keywords
insulin
treating
diabetis
oral administration
preventing type
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69132688T
Other languages
English (en)
Other versions
DE69132688T2 (de
Inventor
Howard L Weiner
George Eisenbarth
David A Hafler
Zhengri Zhang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Autoimmune Inc
Original Assignee
Autoimmune Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Autoimmune Inc filed Critical Autoimmune Inc
Application granted granted Critical
Publication of DE69132688D1 publication Critical patent/DE69132688D1/de
Publication of DE69132688T2 publication Critical patent/DE69132688T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/39—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0008—Antigens related to auto-immune diseases; Preparations to induce self-tolerance
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A61K2039/541—Mucosal route
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A61K2039/541—Mucosal route
    • A61K2039/542—Mucosal route oral/gastrointestinal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A61K2039/541—Mucosal route
    • A61K2039/543—Mucosal route intranasal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
DE69132688T 1990-10-10 1991-10-10 Methode zur behandlung und vorbeugung von typ-1 diabetis durch orale verabreichung von insulin Expired - Lifetime DE69132688T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US59546890A 1990-10-10 1990-10-10
PCT/US1991/007475 WO1992006704A1 (en) 1990-10-10 1991-10-10 Method of treating or preventing type 1 diabetes by oral administration of insulin

Publications (2)

Publication Number Publication Date
DE69132688D1 true DE69132688D1 (de) 2001-09-20
DE69132688T2 DE69132688T2 (de) 2001-11-29

Family

ID=24383359

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69132688T Expired - Lifetime DE69132688T2 (de) 1990-10-10 1991-10-10 Methode zur behandlung und vorbeugung von typ-1 diabetis durch orale verabreichung von insulin

Country Status (15)

Country Link
US (5) US5763396A (de)
EP (1) EP0552256B1 (de)
JP (1) JP2548056B2 (de)
KR (1) KR100239743B1 (de)
AT (1) ATE204178T1 (de)
AU (1) AU659419B2 (de)
BR (1) BR9106977A (de)
CA (1) CA2093806C (de)
DE (1) DE69132688T2 (de)
DK (1) DK0552256T3 (de)
ES (1) ES2162615T3 (de)
HU (2) HU225054B1 (de)
IL (1) IL99699A (de)
NO (1) NO319370B1 (de)
WO (1) WO1992006704A1 (de)

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US5763396A (en) 1998-06-09
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EP0552256A1 (de) 1993-07-28
DK0552256T3 (da) 2001-12-10
WO1992006704A1 (en) 1992-04-30
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JP2548056B2 (ja) 1996-10-30
KR100239743B1 (ko) 2000-02-01
US5843886A (en) 1998-12-01
AU659419B2 (en) 1995-05-18
ATE204178T1 (de) 2001-09-15
CA2093806C (en) 2003-12-30
CA2093806A1 (en) 1992-04-11
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US20010056063A1 (en) 2001-12-27
US5643868A (en) 1997-07-01
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BR9106977A (pt) 1993-08-31
DE69132688T2 (de) 2001-11-29
NO931267L (no) 1993-05-05
JPH06504986A (ja) 1994-06-09
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