DE69133513D1 - Verfahren zur Vervendung von Nukleinsäureliganden - Google Patents

Verfahren zur Vervendung von Nukleinsäureliganden

Info

Publication number
DE69133513D1
DE69133513D1 DE69133513T DE69133513T DE69133513D1 DE 69133513 D1 DE69133513 D1 DE 69133513D1 DE 69133513 T DE69133513 T DE 69133513T DE 69133513 T DE69133513 T DE 69133513T DE 69133513 D1 DE69133513 D1 DE 69133513D1
Authority
DE
Germany
Prior art keywords
nucleic acid
acid ligands
nucleic acids
referred
ligands
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69133513T
Other languages
English (en)
Other versions
DE69133513T2 (de
Inventor
Larry Gold
Craig Tuerk
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Gilead Sciences Inc
Original Assignee
Gilead Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24138463&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69133513(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Gilead Sciences Inc filed Critical Gilead Sciences Inc
Application granted granted Critical
Publication of DE69133513D1 publication Critical patent/DE69133513D1/de
Publication of DE69133513T2 publication Critical patent/DE69133513T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/115—Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith ; Nucleic acids binding to non-nucleic acids, e.g. aptamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/547—Chelates, e.g. Gd-DOTA or Zinc-amino acid chelates; Chelate-forming compounds, e.g. DOTA or ethylenediamine being covalently linked or complexed to the pharmacologically- or therapeutically-active agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/549—Sugars, nucleosides, nucleotides or nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1048—SELEX
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1241—Nucleotidyltransferases (2.7.7)
    • C12N9/1276—RNA-directed DNA polymerase (2.7.7.49), i.e. reverse transcriptase or telomerase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6804—Nucleic acid analysis using immunogens
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6811—Selection methods for production or design of target specific oligonucleotides or binding molecules
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G01N33/535—Production of labelled immunochemicals with enzyme label or co-enzymes, co-factors, enzyme inhibitors or enzyme substrates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56983—Viruses
    • G01N33/56988—HIV or HTLV
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6842—Proteomic analysis of subsets of protein mixtures with reduced complexity, e.g. membrane proteins, phosphoproteins, organelle proteins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • G01N33/76—Human chorionic gonadotropin including luteinising hormone, follicle stimulating hormone, thyroid stimulating hormone or their receptors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/13—Decoys
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/322—2'-R Modification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/50—Physical structure
    • C12N2310/53—Physical structure partially self-complementary or closed
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F02—COMBUSTION ENGINES; HOT-GAS OR COMBUSTION-PRODUCT ENGINE PLANTS
    • F02B—INTERNAL-COMBUSTION PISTON ENGINES; COMBUSTION ENGINES IN GENERAL
    • F02B75/00—Other engines
    • F02B75/02—Engines characterised by their cycles, e.g. six-stroke
    • F02B2075/022—Engines characterised by their cycles, e.g. six-stroke having less than six strokes per cycle
    • F02B2075/027—Engines characterised by their cycles, e.g. six-stroke having less than six strokes per cycle four
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
    • G01N2333/08—RNA viruses
    • G01N2333/15—Retroviridae, e.g. bovine leukaemia virus, feline leukaemia virus, feline leukaemia virus, human T-cell leukaemia-lymphoma virus
    • G01N2333/155—Lentiviridae, e.g. visna-maedi virus, equine infectious virus, FIV, SIV
    • G01N2333/16—HIV-1, HIV-2
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
    • G01N2333/08—RNA viruses
    • G01N2333/15—Retroviridae, e.g. bovine leukaemia virus, feline leukaemia virus, feline leukaemia virus, human T-cell leukaemia-lymphoma virus
    • G01N2333/155—Lentiviridae, e.g. visna-maedi virus, equine infectious virus, FIV, SIV
    • G01N2333/16—HIV-1, HIV-2
    • G01N2333/163—Regulatory proteins, e.g. tat, nef, rev, vif, vpu, vpr, vpt, vpx
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/475—Assays involving growth factors
    • G01N2333/50—Fibroblast growth factors [FGF]
    • G01N2333/503—Fibroblast growth factors [FGF] basic FGF [bFGF]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/575—Hormones
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/575—Hormones
    • G01N2333/62—Insulins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/81—Protease inhibitors
    • G01N2333/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • G01N2333/811—Serine protease (E.C. 3.4.21) inhibitors
    • G01N2333/8121—Serpins
    • G01N2333/8125—Alpha-1-antitrypsin
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/95—Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
    • G01N2333/964—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue
    • G01N2333/96425—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals
    • G01N2333/96427—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general
    • G01N2333/9643—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general with EC number
    • G01N2333/96433—Serine endopeptidases (3.4.21)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/95—Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
    • G01N2333/964—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue
    • G01N2333/96425—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals
    • G01N2333/96427—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general
    • G01N2333/9643—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general with EC number
    • G01N2333/96433—Serine endopeptidases (3.4.21)
    • G01N2333/96436—Granzymes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/95—Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
    • G01N2333/964—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue
    • G01N2333/96425—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals
    • G01N2333/96427—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general
    • G01N2333/9643—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general with EC number
    • G01N2333/96433—Serine endopeptidases (3.4.21)
    • G01N2333/96441—Serine endopeptidases (3.4.21) with definite EC number
    • G01N2333/96455—Kallikrein (3.4.21.34; 3.4.21.35)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/95—Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
    • G01N2333/964—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue
    • G01N2333/96425—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals
    • G01N2333/96427—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general
    • G01N2333/9643—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general with EC number
    • G01N2333/96486—Metalloendopeptidases (3.4.24)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/966—Elastase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/972—Plasminogen activators
    • G01N2333/9726—Tissue plasminogen activator
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/974—Thrombin
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/976—Trypsin; Chymotrypsin
DE69133513T 1990-06-11 1991-06-10 Verfahren zur Verwendung von Nukleinsäureliganden Expired - Lifetime DE69133513T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US53642890A 1990-06-11 1990-06-11
US536428 1990-06-11

Publications (2)

Publication Number Publication Date
DE69133513D1 true DE69133513D1 (de) 2006-04-27
DE69133513T2 DE69133513T2 (de) 2006-09-21

Family

ID=24138463

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69133513T Expired - Lifetime DE69133513T2 (de) 1990-06-11 1991-06-10 Verfahren zur Verwendung von Nukleinsäureliganden
DE69128350T Expired - Lifetime DE69128350T2 (de) 1990-06-11 1991-06-10 Nukleinsäureliganden

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE69128350T Expired - Lifetime DE69128350T2 (de) 1990-06-11 1991-06-10 Nukleinsäureliganden

Country Status (16)

Country Link
US (8) US5475096A (de)
EP (4) EP0533838B1 (de)
JP (4) JP2763958B2 (de)
KR (1) KR970002255B1 (de)
AT (2) ATE160821T1 (de)
AU (1) AU663053B2 (de)
CA (1) CA2084987C (de)
DE (2) DE69133513T2 (de)
DK (2) DK0786469T3 (de)
ES (2) ES2259800T3 (de)
GR (1) GR3025594T3 (de)
IE (1) IE911979A1 (de)
IL (2) IL98456A (de)
NZ (1) NZ238492A (de)
RU (1) RU2198931C2 (de)
WO (1) WO1991019813A1 (de)

Families Citing this family (981)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5831066A (en) * 1988-12-22 1998-11-03 The Trustees Of The University Of Pennsylvania Regulation of bcl-2 gene expression
US5639595A (en) * 1990-05-01 1997-06-17 Isis Phamaceuticals, Inc. Identification of novel drugs and reagents
US5705337A (en) * 1990-06-11 1998-01-06 Nexstar Pharmaceuticals, Inc. Systematic evolution of ligands by exponential enrichment: chemi-SELEX
US5849890A (en) * 1990-06-11 1998-12-15 Nexstar Pharmaceuticals, Inc. High affinity oligonucleotide ligands to chorionic gonadotropin hormone and related glycoprotein hormones
US5686592A (en) * 1990-06-11 1997-11-11 Nexstar Pharmaceuticals, Inc. High-affinity oligonucleotide ligands to immunoglobulin E (IgE)
US6001988A (en) * 1990-06-11 1999-12-14 Nexstar Pharmaceuticals, Inc. High affinity nucleic acid ligands to lectins
US5864026A (en) * 1990-06-11 1999-01-26 Nexstar Pharmaceuticals, Inc. Systematic evolution of ligands by exponential enrichment: tissue selex
US6280932B1 (en) * 1990-06-11 2001-08-28 Gilead Sciences, Inc. High affinity nucleic acid ligands to lectins
US6168778B1 (en) 1990-06-11 2001-01-02 Nexstar Pharmaceuticals, Inc. Vascular endothelial growth factor (VEGF) Nucleic Acid Ligand Complexes
US5668264A (en) * 1990-06-11 1997-09-16 Nexstar Pharmaceuticals, Inc. High affinity PDGF nucleic acid ligands
US5972599A (en) 1990-06-11 1999-10-26 Nexstar Pharmaceuticals, Inc. High affinity nucleic acid ligands of cytokines
US5795721A (en) * 1990-06-11 1998-08-18 Nexstar Pharmaceuticals, Inc. High affinity nucleic acid ligands of ICP4
US5683867A (en) * 1990-06-11 1997-11-04 Nexstar Pharmaceuticals, Inc. Systematic evolution of ligands by exponential enrichment: blended SELEX
US6030776A (en) * 1990-06-11 2000-02-29 Nexstar Pharmaceuticals, Inc. Parallel SELEX
US5476766A (en) * 1990-06-11 1995-12-19 Nexstar Pharmaceuticals, Inc. Ligands of thrombin
US5635615A (en) * 1990-06-11 1997-06-03 Nexstar Pharmaceuticals, Inc. High affinity HIV nucleocapsid nucleic acid ligands
US6261774B1 (en) * 1990-06-11 2001-07-17 Gilead Sciences, Inc. Truncation selex method
US6759392B1 (en) * 1990-06-11 2004-07-06 Gilead Sciences, Inc. High affinity RNA ligands of basic fibroblast growth factor
US6344321B1 (en) * 1990-06-11 2002-02-05 Gilead Sciences, Inc. Nucleic acid ligands which bind to hepatocyte growth factor/scatter factor (HGF/SF) or its receptor c-met
US5648214A (en) * 1990-06-11 1997-07-15 University Research Corporation High-affinity oligonucleotide ligands to the tachykinin substance P
US5580737A (en) * 1990-06-11 1996-12-03 Nexstar Pharmaceuticals, Inc. High-affinity nucleic acid ligands that discriminate between theophylline and caffeine
US5654151A (en) * 1990-06-11 1997-08-05 Nexstar Pharmaceuticals, Inc. High affinity HIV Nucleocapsid nucleic acid ligands
US5496938A (en) * 1990-06-11 1996-03-05 Nexstar Pharmaceuticals, Inc. Nucleic acid ligands to HIV-RT and HIV-1 rev
US6177557B1 (en) 1990-06-11 2001-01-23 Nexstar Pharmaceuticals, Inc. High affinity ligands of basic fibroblast growth factor and thrombin
US20060084797A1 (en) * 1990-06-11 2006-04-20 Gilead Sciences, Inc. High affinity TGFbeta nucleic acid ligands and inhibitors
US5660985A (en) 1990-06-11 1997-08-26 Nexstar Pharmaceuticals, Inc. High affinity nucleic acid ligands containing modified nucleotides
US5674685A (en) * 1990-06-11 1997-10-07 Nexstar Pharmaceuticals, Inc. High affinity PDGF nucleic acid ligands
US6465189B1 (en) 1990-06-11 2002-10-15 Gilead Sciences, Inc. Systematic evolution of ligands by exponential enrichment: blended selex
US5472841A (en) * 1990-06-11 1995-12-05 Nexstar Pharmaceuticals, Inc. Methods for identifying nucleic acid ligands of human neutrophil elastase
US6395888B1 (en) * 1996-02-01 2002-05-28 Gilead Sciences, Inc. High affinity nucleic acid ligands of complement system proteins
WO1995008003A1 (en) * 1993-09-17 1995-03-23 University Research Corporation Systematic evolution of ligands by exponential enrichment: photoselection of nucleic acid ligands and solution selex
US5503978A (en) * 1990-06-11 1996-04-02 University Research Corporation Method for identification of high affinity DNA ligands of HIV-1 reverse transcriptase
US6465188B1 (en) * 1990-06-11 2002-10-15 Gilead Sciences, Inc. Nucleic acid ligand complexes
US6331394B1 (en) * 1991-06-10 2001-12-18 Gilead Sciences, Inc. Nucleic acid ligands to integrins
US20040132067A1 (en) * 1990-06-11 2004-07-08 Somalogic, Inc. Systematic evolution of ligands by exponential enrichment: photoselection of nucleic acid ligands and solution selex
US6011020A (en) * 1990-06-11 2000-01-04 Nexstar Pharmaceuticals, Inc. Nucleic acid ligand complexes
US6001577A (en) 1998-06-08 1999-12-14 Nexstar Pharmaceuticals, Inc. Systematic evolution of ligands by exponential enrichment: photoselection of nucleic acid ligands and solution selex
US6083696A (en) * 1990-06-11 2000-07-04 Nexstar Pharmaceuticals, Inc. Systematic evolution of ligands exponential enrichment: blended selex
US5869641A (en) * 1990-06-11 1999-02-09 Nexstar Pharmaceuticals, Inc. High affinity nucleic acid ligands of CD4
US5707796A (en) * 1990-06-11 1998-01-13 Nexstar Pharmaceuticals, Inc. Method for selecting nucleic acids on the basis of structure
US5766853A (en) * 1990-06-11 1998-06-16 Nexstar Pharmaceuticals, Inc. Method for identification of high affinity nucleic acid ligands to selectins
US5780228A (en) * 1990-06-11 1998-07-14 Nexstar Pharmaceuticals, Inc. High affinity nucleic acid ligands to lectins
US6569620B1 (en) * 1990-06-11 2003-05-27 Somalogic, Inc. Method for the automated generation of nucleic acid ligands
US5861254A (en) * 1997-01-31 1999-01-19 Nexstar Pharmaceuticals, Inc. Flow cell SELEX
US6716580B2 (en) 1990-06-11 2004-04-06 Somalogic, Inc. Method for the automated generation of nucleic acid ligands
US5962219A (en) * 1990-06-11 1999-10-05 Nexstar Pharmaceuticals, Inc. Systematic evolution of ligands by exponential enrichment: chemi-selex
US5587468A (en) * 1990-06-11 1996-12-24 University Research Corporation High affinity nucleic acid ligands to HIV integrase
US5637459A (en) * 1990-06-11 1997-06-10 Nexstar Pharmaceuticals, Inc. Systematic evolution of ligands by exponential enrichment: chimeric selex
US5637682A (en) * 1990-06-11 1997-06-10 Nexstar Pharmaceuticals, Inc. High-affinity oligonucleotide ligands to the tachykinin substance P
US6147204A (en) * 1990-06-11 2000-11-14 Nexstar Pharmaceuticals, Inc. Nucleic acid ligand complexes
US5629155A (en) * 1990-06-11 1997-05-13 Nexstar Pharmaceuticals, Inc. High-affinity oligonucleotide ligands to immunoglobulin E (IgE)
US5723289A (en) * 1990-06-11 1998-03-03 Nexstar Pharmaceuticals, Inc. Parallel selex
US6346611B1 (en) 1990-06-11 2002-02-12 Gilead Sciences, Inc. High affinity TGfβ nucleic acid ligands and inhibitors
US6232071B1 (en) * 1990-06-11 2001-05-15 Gilead Sciences, Inc. Tenascin-C nucleic acid ligands
US5843701A (en) * 1990-08-02 1998-12-01 Nexstar Pharmaceticals, Inc. Systematic polypeptide evolution by reverse translation
JPH06503715A (ja) * 1990-09-21 1994-04-28 フレッド ハッチンソン キャンサー リサーチ センター タンパク質配列特異的オリゴヌクレオチド配列
US5840867A (en) * 1991-02-21 1998-11-24 Gilead Sciences, Inc. Aptamer analogs specific for biomolecules
AU1435492A (en) * 1991-02-21 1992-09-15 Gilead Sciences, Inc. Aptamer specific for biomolecules and method of making
US6762290B1 (en) * 1999-07-29 2004-07-13 Gilead Sciences, Inc. High affinity vascular endothelial growth factor (VEGF) receptor nucleic acid ligands and inhibitors
US5582981A (en) * 1991-08-14 1996-12-10 Gilead Sciences, Inc. Method for identifying an oligonucleotide aptamer specific for a target
WO1993005182A1 (en) * 1991-09-05 1993-03-18 Isis Pharmaceuticals, Inc. Determination of oligonucleotides for therapeutics, diagnostics and research reagents
EP0623141A1 (de) * 1992-01-13 1994-11-09 The President And Fellows Of Harvard College Auswahl von bindungsmolekulen
US5783384A (en) * 1992-01-13 1998-07-21 President And Fellows Of Harvard College Selection of binding-molecules
US20040127446A1 (en) * 1992-05-14 2004-07-01 Lawrence Blatt Oligonucleotide mediated inhibition of hepatitis B virus and hepatitis C virus replication
US5756291A (en) * 1992-08-21 1998-05-26 Gilead Sciences, Inc. Aptamers specific for biomolecules and methods of making
WO1994006934A1 (en) * 1992-09-11 1994-03-31 Duke University Method for deriving epitopes
US6582902B1 (en) 1992-09-30 2003-06-24 Jack D. Keene Method for deriving epitopes
CA2145761C (en) * 1992-09-29 2009-12-22 Larry M. Gold Nucleic acid ligands and methods for producing the same
WO1994009158A1 (en) * 1992-10-14 1994-04-28 University Research Corporation Method for selecting nucleic acids on the basis of structure
US5998142A (en) * 1993-09-08 1999-12-07 Nexstar Pharmaceuticals, Inc. Systematic evolution of ligands by exponential enrichment: chemi-SELEX
CA2169536A1 (en) * 1993-09-08 1995-03-16 Larry Gold Nucleic acid ligands and improved methods for producing the same
US6458539B1 (en) * 1993-09-17 2002-10-01 Somalogic, Inc. Photoselection of nucleic acid ligands
AU692212B2 (en) * 1993-12-17 1998-06-04 Roger S. Cubicciotti Nucleotide-directed assembly of bimolecular and multimolecular drugs and devices
GB9401833D0 (en) * 1994-02-01 1994-03-30 Isis Innovation Method for discovering ligands
US7153948B2 (en) 1994-04-25 2006-12-26 Gilead Sciences, Inc. High-affinity oligonucleotide ligands to vascular endothelial growth factor (VEGF)
IL114237A (en) * 1994-07-14 2000-08-31 Schering Ag Oligonucleotide conjugates and diagnostic processes utilizing the same
US20020077306A1 (en) * 1994-07-14 2002-06-20 Ludger Dinkelborg Conjugates made of metal complexes and oligonucleotides, agents containing the conjugates, their use in radiodiagnosis as well as process for their production
US6207646B1 (en) 1994-07-15 2001-03-27 University Of Iowa Research Foundation Immunostimulatory nucleic acid molecules
US6239116B1 (en) 1994-07-15 2001-05-29 University Of Iowa Research Foundation Immunostimulatory nucleic acid molecules
US6048698A (en) * 1994-09-20 2000-04-11 Nexstar Pharmaceuticals, Inc. Parallel SELEX™
US5663064A (en) * 1995-01-13 1997-09-02 University Of Vermont Ribozymes with RNA protein binding site
AU5301996A (en) * 1995-03-06 1996-09-23 Nexstar Pharmaceuticals, Inc. High-affinity oligonucleotide ligands to secretory phospholipase a2(spla2)
US6013443A (en) 1995-05-03 2000-01-11 Nexstar Pharmaceuticals, Inc. Systematic evolution of ligands by exponential enrichment: tissue SELEX
AU732961B2 (en) * 1995-05-03 2001-05-03 Nexstar Pharmaceuticals, Inc. Systematic evolution of ligands by exponential enrichment: tissue selex
WO1996034874A1 (en) 1995-05-03 1996-11-07 Nexstar Pharmaceuticals, Inc. Nucleic acid ligands of tissue target
JP5637528B2 (ja) * 1995-05-04 2014-12-10 ギリード・サイエンシズ・インコーポレーテッド 核酸リガンド複合体
US8071737B2 (en) 1995-05-04 2011-12-06 Glead Sciences, Inc. Nucleic acid ligand complexes
EP2168973A1 (de) 1995-05-04 2010-03-31 Gilead Sciences, Inc. Komplexe von Nucleinsäureligand
US5859228A (en) * 1995-05-04 1999-01-12 Nexstar Pharmaceuticals, Inc. Vascular endothelial growth factor (VEGF) nucleic acid ligand complexes
US5723594A (en) * 1995-06-07 1998-03-03 Nexstar Pharmaceuticals, Inc. High affinity PDGF nucleic acid ligands
US6699843B2 (en) * 1995-06-07 2004-03-02 Gilead Sciences, Inc. Method for treatment of tumors using nucleic acid ligands to PDGF
US6183967B1 (en) 1995-06-07 2001-02-06 Nexstar Pharmaceuticals Nucleic acid ligand inhibitors to DNA polymerases
US20090118481A1 (en) * 1995-06-07 2009-05-07 Gilead Sciences, Inc. High Affinity Nucleic Acid Ligands To Lectins
US6229002B1 (en) * 1995-06-07 2001-05-08 Nexstar Pharmaceuticlas, Inc. Platelet derived growth factor (PDGF) nucleic acid ligand complexes
DK0833944T3 (da) * 1995-06-07 2009-05-11 Gilead Sciences Inc Nucleinsyreligander som binder til og inhiberer DNA-polymeraser
US20040220128A1 (en) * 1995-10-26 2004-11-04 Sirna Therapeutics, Inc. Nucleic acid based modulation of female reproductive diseases and conditions
US20040142895A1 (en) * 1995-10-26 2004-07-22 Sirna Therapeutics, Inc. Nucleic acid-based modulation of gene expression in the vascular endothelial growth factor pathway
US20040102389A1 (en) * 1995-10-26 2004-05-27 Ribozyme Pharmaceuticals, Inc. Nucleic acid-mediated treatment of diseases or conditions related to levels of vascular endothelial growth factor receptor (VEGF-R)
DE19543750C2 (de) * 1995-11-24 1997-10-23 Crinos Industria Farmaco Cathepsin G inhibierende Aptamere
US20020106647A1 (en) * 1996-07-24 2002-08-08 Segal Andrew H. Nucleic acid compositions and methods of introducing nucleic acids into cells
US6838238B1 (en) 1996-10-17 2005-01-04 Invitrogen Corporation Morphatides: novel shape and structure libraries
US20020022227A1 (en) * 1996-10-17 2002-02-21 Short Jay M. Morphatides: novel shape and structure libraries
US6426335B1 (en) * 1997-10-17 2002-07-30 Gilead Sciences, Inc. Vascular endothelial growth factor (VEGF) nucleic acid ligand complexes
US6051698A (en) * 1997-06-06 2000-04-18 Janjic; Nebojsa Vascular endothelial growth factor (VEGF) nucleic acid ligand complexes
US6737236B1 (en) 1997-01-08 2004-05-18 Proligo, Llc Bioconjugation of macromolecules
EP0996741A4 (de) * 1997-01-23 2004-06-09 Immusol Inc Funktionelle genanalyse und genauffindung mit hilfe von willkürlichen oder zielspezifischen ribozym genvektorbibliotheken
US6143496A (en) 1997-04-17 2000-11-07 Cytonix Corporation Method of sampling, amplifying and quantifying segment of nucleic acid, polymerase chain reaction assembly having nanoliter-sized sample chambers, and method of filling assembly
US5834199A (en) * 1997-04-29 1998-11-10 North Carolina State University Methods of identifying transition metal complexes that selectively cleave regulatory elements of mRNA and uses thereof
CA2220785A1 (en) * 1997-12-02 1999-06-02 Noureddine Rouissi Selective technique for rapid identification of proteins and genes and uses thereof
US6268131B1 (en) 1997-12-15 2001-07-31 Sequenom, Inc. Mass spectrometric methods for sequencing nucleic acids
US20070166741A1 (en) * 1998-12-14 2007-07-19 Somalogic, Incorporated Multiplexed analyses of test samples
US6242246B1 (en) 1997-12-15 2001-06-05 Somalogic, Inc. Nucleic acid ligand diagnostic Biochip
WO2003070984A1 (en) 2002-02-15 2003-08-28 Somalogic, Inc. Methods and reagents for detecting target binding by nucleic acid ligands
US5989823A (en) * 1998-09-18 1999-11-23 Nexstar Pharmaceuticals, Inc. Homogeneous detection of a target through nucleic acid ligand-ligand beacon interaction
EP1049803A4 (de) 1997-12-15 2002-08-21 Nexstar Pharmaceuticals Inc Gleichmässige erkennung von zielmolekül durch nukleinsäure ligand - beacon ligand interaktion
WO1999033971A1 (en) * 1997-12-31 1999-07-08 Medical College Of Georgia Research Institute, Inc. Oligomers that bind to ku protein
DE19800899A1 (de) * 1998-01-13 1999-07-15 Biotecon Ges Fuer Biotechnologische Entwicklung & Consulting Mbh Oligoliganden mit Bindungsvermögen etc.
US6537747B1 (en) 1998-02-03 2003-03-25 Lucent Technologies Inc. Data transmission using DNA oligomers
US7393529B2 (en) * 1998-04-09 2008-07-01 Idexx Laboratories, Inc. Methods and compositions for inhibiting binding of IgE to a high affinity receptor
US6180348B1 (en) 1998-04-20 2001-01-30 Weihua Li Method of isolating target specific oligonucleotide ligands
US6287765B1 (en) * 1998-05-20 2001-09-11 Molecular Machines, Inc. Methods for detecting and identifying single molecules
US6225063B1 (en) 1998-05-22 2001-05-01 University Technology Corporation RNA channels in biological membranes
EP1112377A4 (de) * 1998-06-22 2004-11-10 Univ California Nukleinsäure-gekoppelte kolorimetrische analytdetektoren
JP3662850B2 (ja) 1998-06-24 2005-06-22 イルミナ インコーポレイテッド 微小球を有するアレイセンサーのデコード
US6100035A (en) 1998-07-14 2000-08-08 Cistem Molecular Corporation Method of identifying cis acting nucleic acid elements
US20040259079A1 (en) * 1998-07-22 2004-12-23 Immusol, Inc. Substantially complete ribozyme libraries
AU5492499A (en) * 1998-08-21 2000-03-14 University Of Virginia Patent Foundation Signal generating oligonucleotide-based biosensor
US20060172925A1 (en) * 1998-10-26 2006-08-03 Board Of Regents, The University Of Texas System Thio-siRNA aptamers
US6867289B1 (en) * 1998-10-26 2005-03-15 Board Of Regents, The University Of Texas Systems Thio-modified aptamer synthetic methods and compositions
US20040242521A1 (en) * 1999-10-25 2004-12-02 Board Of Regents, The University Of Texas System Thio-siRNA aptamers
EP1002875A1 (de) * 1998-11-17 2000-05-24 Mira Diagnostica GmbH Oligonucleotid Inhibitor von thermostabilen Polymerasen
US6927024B2 (en) * 1998-11-30 2005-08-09 Genentech, Inc. PCR assay
US7666609B1 (en) 1998-12-01 2010-02-23 Shanghai Cp Guojian Pharmaceutical Co. Ltd. Method and composition for diagnosis of melanocytic lesions
US6429027B1 (en) 1998-12-28 2002-08-06 Illumina, Inc. Composite arrays utilizing microspheres
US6858390B2 (en) * 1998-12-31 2005-02-22 Ingeneus Corporation Aptamers containing sequences of nucleic acid or nucleic acid analogues bound homologously, or in novel complexes
AU777823B2 (en) * 1999-01-19 2004-11-04 Somalogic, Inc. Method and apparatus for the automated generation of nucleic acid ligands
US20030054360A1 (en) * 1999-01-19 2003-03-20 Larry Gold Method and apparatus for the automated generation of nucleic acid ligands
CA2259745A1 (en) * 1999-01-19 2000-07-19 Guy Tremblay Generation of oligonucleotide libraries representative of genomes or expressed mrnas (cdnas) and use thereof
US6329145B1 (en) 1999-02-09 2001-12-11 Gilead Science, Inc. Determining non-nucleic acid molecule binding to target by competition with nucleic acid ligand
US7189506B1 (en) 1999-03-03 2007-03-13 Genelabs Technologies, Inc. DNA binding compound-mediated molecular switch system
US6794136B1 (en) 2000-11-20 2004-09-21 Sangamo Biosciences, Inc. Iterative optimization in the design of binding proteins
US20060275782A1 (en) 1999-04-20 2006-12-07 Illumina, Inc. Detection of nucleic acid reactions on bead arrays
US20030207295A1 (en) * 1999-04-20 2003-11-06 Kevin Gunderson Detection of nucleic acid reactions on bead arrays
EP1196630B2 (de) 1999-04-20 2018-10-17 Illumina, Inc. Detektion von nukleinsäurereaktionen auf kügelchen-arrays
US6680377B1 (en) * 1999-05-14 2004-01-20 Brandeis University Nucleic acid-based detection
US8080380B2 (en) 1999-05-21 2011-12-20 Illumina, Inc. Use of microfluidic systems in the detection of target analytes using microsphere arrays
US8481268B2 (en) 1999-05-21 2013-07-09 Illumina, Inc. Use of microfluidic systems in the detection of target analytes using microsphere arrays
US8137906B2 (en) 1999-06-07 2012-03-20 Sloning Biotechnology Gmbh Method for the synthesis of DNA fragments
US6280943B1 (en) * 1999-06-17 2001-08-28 Gilead Sciences, Inc. 2′-fluoropyrimidine anti-calf intestinal phosphatase nucleic acid ligands
US7074586B1 (en) 1999-06-17 2006-07-11 Source Precision Medicine, Inc. Quantitative assay for low abundance molecules
WO2001006249A2 (en) 1999-07-02 2001-01-25 Conceptual Mindworks, Inc. Organic semiconductor recognition complex and system
US6387620B1 (en) * 1999-07-28 2002-05-14 Gilead Sciences, Inc. Transcription-free selex
US6171795B1 (en) * 1999-07-29 2001-01-09 Nexstar Pharmaceuticals, Inc. Nucleic acid ligands to CD40ligand
US6506887B1 (en) * 1999-07-29 2003-01-14 Somalogic, Incorporated Conditional-selex
US7005260B1 (en) 2000-01-28 2006-02-28 Gilead Sciences, Inc. Tenascin-C nucleic acid ligands
BR0003768A (pt) * 1999-08-26 2001-07-03 Tomas Antonio Santa Coloma Oligocorpos monoclonais e policlonais (reagentes sintéticos semelhantes a anticorpos baseados em oligonucleotìdeos) e um método de produção dos oligocorpos
DE60039120D1 (de) 1999-11-24 2008-07-17 Univ New York State Res Found Katalytische rnas mit aminoacylierender aktivität
US6558911B1 (en) 1999-12-10 2003-05-06 Oregon Health Sciences University Sperm quality assay
CA2328356A1 (en) 1999-12-22 2001-06-22 Itty Atcravi Recreational vehicles
US7645743B2 (en) * 1999-12-22 2010-01-12 Altermune, Llc Chemically programmable immunity
US20010039015A1 (en) * 2000-01-21 2001-11-08 Edward Sauter Nipple aspirate fluid specific microarrays
US20030087265A1 (en) * 2000-01-21 2003-05-08 Edward Sauter Specific microarrays for breast cancer screening
EP1967595A3 (de) 2000-02-16 2008-12-03 Illumina, Inc. Paralleles Genotypisieren von mehreren Patientenproben
AU2001249386A1 (en) 2000-03-22 2001-10-03 Quantum Dot Corporation Methods of using semiconductor nanocrystals in bead-based nucleic acid assays
CA2405715C (en) * 2000-04-14 2011-11-15 Genencor International, Inc. Methods for selective targeting
US7129326B2 (en) * 2000-04-14 2006-10-31 Genencor International, Inc. Methods for selective targeting
US7682837B2 (en) * 2000-05-05 2010-03-23 Board Of Trustees Of Leland Stanford Junior University Devices and methods to form a randomly ordered array of magnetic beads and uses thereof
US6471968B1 (en) 2000-05-12 2002-10-29 Regents Of The University Of Michigan Multifunctional nanodevice platform
US8914114B2 (en) 2000-05-23 2014-12-16 The Feinstein Institute For Medical Research Inhibition of inflammatory cytokine production by cholinergic agonists and vagus nerve stimulation
US20020155084A1 (en) * 2000-06-02 2002-10-24 The Regents Of The University Of The Michigan Nanoemulsion formulations
US20030207271A1 (en) * 2000-06-30 2003-11-06 Holwitt Eric A. Methods and compositions for biological sensors
US7892484B2 (en) * 2000-06-30 2011-02-22 Conceptual Mindworks, Inc. Methods and compositions for neutralizing anthrax and other bioagents
WO2002006827A1 (en) * 2000-07-05 2002-01-24 The General Hospital Corporation Compounds and methods for fluorescently labeling nucleic acids
US6376190B1 (en) 2000-09-22 2002-04-23 Somalogic, Inc. Modified SELEX processes without purified protein
WO2002026932A2 (en) * 2000-09-26 2002-04-04 Duke University Rna aptamers and methods for identifying the same
DE10049074A1 (de) * 2000-10-02 2002-04-18 Andreas Kage Verfahren zur Selektion hochaffin an ein Target bindender Nukleinsäuren
DE10048944A1 (de) * 2000-10-03 2002-04-18 Andreas Kage Verfahren zur Selektion hochaffin an ein Target bindender Nukleinsäuren durch zweidimensionale Auftrennung
US20050059031A1 (en) 2000-10-06 2005-03-17 Quantum Dot Corporation Method for enhancing transport of semiconductor nanocrystals across biological membranes
ATE536550T1 (de) 2000-10-06 2011-12-15 Life Technologies Corp Halbleiter nanokristalle enthaltende transfektibare mizellen
JP4176466B2 (ja) 2000-10-16 2008-11-05 ギリード・サイエンシズ・インコーポレーテッド 前立腺特異的膜抗原に対する核酸リガンド
US20050054942A1 (en) 2002-01-22 2005-03-10 Melker Richard J. System and method for therapeutic drug monitoring
JP4379561B2 (ja) * 2001-01-30 2009-12-09 キヤノンファインテック株式会社 シート処理装置及びこれを備えた画像形成装置
US7115369B2 (en) * 2001-03-15 2006-10-03 Iowa State University Research Foundation, Inc. Functional nucleic acid probes and uses thereof
WO2002074978A2 (en) 2001-03-19 2002-09-26 President And Fellows Of Harvard College Nucleic acid shuffling
US7807408B2 (en) * 2001-03-19 2010-10-05 President & Fellows Of Harvard College Directed evolution of proteins
JP2004532022A (ja) * 2001-03-26 2004-10-21 サーナ・セラピューティクス・インコーポレイテッド Ｂ型肝炎ウイルスおよびｃ型肝炎ウイルスの複製のオリゴヌクレオチド媒介性阻害
EP1387671A1 (de) 2001-05-03 2004-02-11 MASSACHUSETTS EYE & EAR INFIRMARY Implantierbare arzneistoffverabreichungsvorrichtung und verwendung derselben
DE10122847A1 (de) * 2001-05-11 2002-11-21 Noxxon Pharma Ag Enterotoxin B bindende Nukleinsäure
US20040006035A1 (en) * 2001-05-29 2004-01-08 Dennis Macejak Nucleic acid mediated disruption of HIV fusogenic peptide interactions
WO2002097114A2 (en) * 2001-05-29 2002-12-05 Sirna Therapeutics, Inc. Nucleic acid treatment of diseases or conditions related to levels of ras, her2 and hiv
US20050080031A1 (en) * 2001-05-18 2005-04-14 Sirna Therapeutics, Inc. Nucleic acid treatment of diseases or conditions related to levels of Ras, HER2 and HIV
US20040198682A1 (en) * 2001-11-30 2004-10-07 Mcswiggen James RNA interference mediated inhibition of placental growth factor gene expression using short interfering nucleic acid (siNA)
CA2448567C (en) * 2001-05-25 2014-05-20 Duke University Modulators of nucleic acid ligands
EP1434778A4 (de) 2001-05-31 2005-07-13 Medarex Inc Cytotoxine und prodrugs, linker und stabilisatoren dafür
US8030465B2 (en) 2001-06-29 2011-10-04 Medimolecular Pty Ltd Nucleic acid ligands to complex targets
AU2775402A (en) * 2001-06-29 2003-01-02 Medimolecular Pty Ltd Nucleic acid ligands to complex targets
CA2456725A1 (en) 2001-08-17 2003-02-27 Neose Technologies, Inc. Chemo-enzymatic synthesis of sialylated oligosaccharides
KR100991644B1 (ko) 2001-08-17 2010-11-02 콜리 파마슈티칼 게엠베하 활성이 개량된 조합 모티프 면역자극성 올리고뉴클레오티드
WO2003029492A1 (en) * 2001-09-28 2003-04-10 Justin Gallivan Metabolic genes and related methods and compositions
WO2003057709A2 (en) * 2001-10-19 2003-07-17 Sirna Therapeutics, Inc Method and reagent for the detection of proteins and peptides
FI115343B (fi) * 2001-10-22 2005-04-15 Filtronic Lk Oy Sisäinen monikaista-antenni
WO2003035665A1 (de) 2001-10-26 2003-05-01 Noxxon Pharma Ag Modifizierte l-nukleinsäure
US20030162190A1 (en) * 2001-11-15 2003-08-28 Gorenstein David G. Phosphoromonothioate and phosphorodithioate oligonucleotide aptamer chip for functional proteomics
ATE414767T1 (de) 2001-11-22 2008-12-15 Sloning Biotechnology Gmbh Nukleinsäure-linker und deren verwendung in der gensynthese
AU2002357240A1 (en) * 2001-12-14 2003-06-30 Yale University Nucleic acid diagnostic reagents and methods for detecting nucleic acids, polynucleotides and oligonucleotides
US7179907B2 (en) 2001-12-18 2007-02-20 Bruce Eaton Antibiotic compounds
US20040002083A1 (en) * 2002-01-29 2004-01-01 Ye Ding Statistical algorithms for folding and target accessibility prediction and design of nucleic acids
US20040052928A1 (en) * 2002-09-06 2004-03-18 Ehud Gazit Peptides and methods using same for diagnosing and treating amyloid-associated diseases
US7781396B2 (en) 2002-01-31 2010-08-24 Tel Aviv University Future Technology Development L.P. Peptides directed for diagnosis and treatment of amyloid-associated disease
AU2003215240A1 (en) * 2002-02-14 2003-09-04 Illumina, Inc. Automated information processing in randomly ordered arrays
US7622248B2 (en) * 2002-02-15 2009-11-24 The Research Foundation Of State University Of New York Ribozymes with broad tRNA aminoacylation activity
WO2003070190A2 (en) * 2002-02-19 2003-08-28 Syntherica Corporation Surrogate antibodies and methods of preparation and use thereof
WO2003106476A1 (en) * 2002-02-20 2003-12-24 Sirna Therapeutics, Inc Nucleic acid mediated inhibition of enterococcus infection and cytolysin toxin activity
US8877901B2 (en) 2002-12-13 2014-11-04 Immunomedics, Inc. Camptothecin-binding moiety conjugates
US7591994B2 (en) 2002-12-13 2009-09-22 Immunomedics, Inc. Camptothecin-binding moiety conjugates
CA2478083A1 (en) 2002-03-05 2003-09-18 Board Of Regents, The University Of Texas System Biospecific contrast agents
US20030219801A1 (en) * 2002-03-06 2003-11-27 Affymetrix, Inc. Aptamer base technique for ligand identification
US20040018515A1 (en) * 2002-04-03 2004-01-29 Diener John L. Compositions selective for adenosine diphosphate and methods of using same
AU2003233243A1 (en) * 2002-05-06 2003-11-17 Noxxon Pharma Ag Method for amplifying nucleic acids
CN101843641B (zh) 2002-05-27 2014-09-17 佩尔·松内·霍尔姆 腺病毒和编码其的核酸的新应用
AU2003238772A1 (en) * 2002-05-31 2003-12-19 Regents Of The University Of Minnesota In vitro evaluation of nucleic acid ligands
US7767803B2 (en) 2002-06-18 2010-08-03 Archemix Corp. Stabilized aptamers to PSMA and their use as prostate cancer therapeutics
US20040249130A1 (en) * 2002-06-18 2004-12-09 Martin Stanton Aptamer-toxin molecules and methods for using same
EP1552002A4 (de) * 2002-06-18 2006-02-08 Archemix Corp Aptamer-toxinmoleküle sowie verfahren zu deren verwendung
US7655790B2 (en) * 2002-07-12 2010-02-02 Sirna Therapeutics, Inc. Deprotection and purification of oligonucleotides and their derivatives
US6989442B2 (en) * 2002-07-12 2006-01-24 Sirna Therapeutics, Inc. Deprotection and purification of oligonucleotides and their derivatives
AU2003261264B2 (en) * 2002-07-25 2008-12-11 Archemix Corp. Regulated aptamer therapeutics
JP4644599B2 (ja) * 2002-08-01 2011-03-02 ノクソン・フアルマ・アクチエンゲゼルシヤフト グレリン結合核酸
IL166718A0 (en) 2002-08-14 2006-01-15 Atugen Ag Further use of protein kinase n beta
EP1393742A1 (de) 2002-08-14 2004-03-03 atugen AG Verwendung von Protein Kinase N beta
US7785799B2 (en) * 2002-08-16 2010-08-31 The Board Of Regents Of The University Of Texas System Compositions and methods related to flavivirus envelope protein domain III antigens
DE10241938A1 (de) * 2002-09-10 2004-03-25 Noxxon Pharma Ag Verfahren zur Selektion von Nukleinsäureliganden
AU2003270509B2 (en) 2002-09-11 2009-03-26 University Of Florida Analyzing nerve cell damage
US9303262B2 (en) 2002-09-17 2016-04-05 Archemix Llc Methods for identifying aptamer regulators
JP2006500030A (ja) 2002-09-20 2006-01-05 イェール ユニバーシティ リボスイッチ、その使用方法、ならびにリボスイッチとともに用いるための組成物
JP2006500959A (ja) * 2002-09-30 2006-01-12 パラレル バイオサイエンス， インコーポレイテッド 動的サンプリング結合によるポリヌクレオチド合成および標識化
JP5116971B2 (ja) 2002-10-15 2013-01-09 インターセル アーゲー Ｂ群連鎖球菌の接着因子をコードする核酸、ｂ群連鎖球菌の接着因子、およびその使用
CA2502610A1 (en) * 2002-10-16 2005-01-13 Board Of Regents Of The University Of Texas System Bead bound combinatorial oligonucleoside phosphorothioate and phosphorodithioate aptamer libraries
MXPA05004134A (es) 2002-10-18 2005-10-05 Atugen Ag Factor involucrado en la metastasis y usos del mismo.
GB0225833D0 (en) * 2002-11-06 2002-12-11 Univ Leeds Nucleic acid ligands and uses therefor
WO2004048596A2 (en) 2002-11-21 2004-06-10 Epicentre Technologies Methods for using primers that encode one strand of a double-stranded promoter
US8039443B2 (en) * 2002-11-21 2011-10-18 Archemix Corporation Stabilized aptamers to platelet derived growth factor and their use as oncology therapeutics
CA2504633A1 (en) * 2002-11-21 2004-06-10 Archemix Corporation Multivalent aptamer therapeutics with improved pharmacodynamic properties and methods of making and using the same
US10100316B2 (en) 2002-11-21 2018-10-16 Archemix Llc Aptamers comprising CPG motifs
US20050124565A1 (en) * 2002-11-21 2005-06-09 Diener John L. Stabilized aptamers to platelet derived growth factor and their use as oncology therapeutics
US8853376B2 (en) 2002-11-21 2014-10-07 Archemix Llc Stabilized aptamers to platelet derived growth factor and their use as oncology therapeutics
CN102584951A (zh) * 2002-11-25 2012-07-18 金克克国际有限公司 皮肤或毛发结合肽
US20050037394A1 (en) * 2002-12-03 2005-02-17 Keefe Anthony D. Method for in vitro selection of 2'-substituted nucleic acids
US7491699B2 (en) 2002-12-09 2009-02-17 Ramot At Tel Aviv University Ltd. Peptide nanostructures and methods of generating and using the same
JP2006512927A (ja) 2002-12-11 2006-04-20 コーリー ファーマシューティカル グループ，インコーポレイテッド ５’ｃｐｇ核酸およびその使用方法
US6936496B2 (en) 2002-12-20 2005-08-30 Hewlett-Packard Development Company, L.P. Nanowire filament
EP2058275A1 (de) 2003-01-07 2009-05-13 Ramot at Tel-Aviv University Ltd. Peptidnanostrukturen mit einem verkapselten Fremdstoff und Verfahren zu ihrer Herstellung
US6943768B2 (en) 2003-02-21 2005-09-13 Xtellus Inc. Thermal control system for liquid crystal cell
US6861251B2 (en) 2003-02-24 2005-03-01 Pritest, Inc. Translucent solid matrix assay device for microarray analysis
WO2004076678A2 (en) * 2003-02-24 2004-09-10 Pritest, Inc. Translucent solid matrix assay device for microarray analysis
JP2006520202A (ja) 2003-03-04 2006-09-07 インターツェル・アクチェンゲゼルシャフト ストレプトコッカス・ピオゲネス抗原
US7140685B2 (en) * 2003-03-11 2006-11-28 Gardner Kenneth J Swivel chair joint
US20060078893A1 (en) 2004-10-12 2006-04-13 Medical Research Council Compartmentalised combinatorial chemistry by microfluidic control
GB0307428D0 (en) 2003-03-31 2003-05-07 Medical Res Council Compartmentalised combinatorial chemistry
US7628994B2 (en) 2003-03-31 2009-12-08 Intercell Ag S. epidermidis antigens
EP1608780B1 (de) * 2003-03-31 2011-08-24 McMASTER UNIVERSITY Aptamerselektionsverfahren
GB0307403D0 (en) 2003-03-31 2003-05-07 Medical Res Council Selection by compartmentalised screening
EP2336357A1 (de) 2003-04-15 2011-06-22 Intercell AG S. pneumoniae Antigene
AU2004232848A1 (en) 2003-04-21 2004-11-04 Archemix Corp. Stabilized aptamers to platelet derived growth factor and their use as oncology therapeutics
US20050250106A1 (en) * 2003-04-24 2005-11-10 David Epstein Gene knock-down by intracellular expression of aptamers
WO2004099411A1 (en) * 2003-05-07 2004-11-18 Novartis Ag A method for dissecting the rna secondary structure dependence of rna-ligand interactions
WO2004099242A2 (en) 2003-05-07 2004-11-18 Intercell Ag Streptococcus agalactiae antigens i + ii
EP1635765B1 (de) * 2003-05-23 2013-07-17 Board Of Regents, The University Of Texas System Strukturbasiertes und kombinatorisch ausgewähltes oligonucleosid-phosphorothioat und phosphorodithioat aptamer targeting ap-1 transkriptionsfaktoren
US8017755B2 (en) 2003-05-23 2011-09-13 President And Fellows Of Harvard College RNA-based transcriptional regulators
EP1635693A2 (de) * 2003-05-23 2006-03-22 Board Of Regents, The University Of Texas System Screening mit hohem durchsatz von aptamer-bibliotheken für die spezifische bindung an proteine auf viren und anderen erregern
DE10325152B4 (de) * 2003-05-30 2011-07-21 Kage, Andreas, Dr., 12207 Verfahren zur quantitativen Bestimmung einer unbekannten Menge einer Zielmolekülspezies
CA2525540A1 (en) 2003-05-30 2004-12-09 Intercell Ag Enterococcus antigens
US20050250094A1 (en) * 2003-05-30 2005-11-10 Nanosphere, Inc. Method for detecting analytes based on evanescent illumination and scatter-based detection of nanoparticle probe complexes
US20050232926A1 (en) * 2003-06-06 2005-10-20 Oncomax Acquisition Corp. Antibodies specific for cancer associated antigen SM5-1 and uses thereof
US7727969B2 (en) 2003-06-06 2010-06-01 Massachusetts Institute Of Technology Controlled release nanoparticle having bound oligonucleotide for targeted delivery
CN1279056C (zh) * 2003-06-06 2006-10-11 马菁 肿瘤相关抗原sm5－1的特异性抗体及其应用
EP1493810A1 (de) 2003-06-30 2005-01-05 Gentium S.p.A. Auf DNA-basierte Aptamere für Cathepsin G
EP1649018A2 (de) 2003-07-10 2006-04-26 Michigan State University Auf sp1 und sp3 abzielende krebstherapien und therapeutika
US20050118611A1 (en) * 2003-07-24 2005-06-02 Board Of Regents, The University Of Texas System Thioaptamers enable discovery of physiological pathways and new therapeutic strategies
US20050054847A1 (en) 2003-08-01 2005-03-10 Invitrogen Corporation Compositions and methods for preparing short RNA molecules and other nucleic acids
US20050043245A1 (en) * 2003-08-11 2005-02-24 Siler -Khodr Theresa M. Non-mammalian GnRH analogs and uses thereof in the immune system
CA2535799A1 (en) 2003-08-15 2005-03-03 University Of Florida Identification of porphyromonas gingivalis virulence polynucleotides for diagnosis, treatment, and monitoring of periodontal diseases
AU2004268614C1 (en) * 2003-08-27 2010-10-28 Ophthotech Corporation Combination therapy for the treatment of ocular neovascular disorders
US7329742B2 (en) 2003-09-04 2008-02-12 The Regents Of The University Of California Aptamers and methods for their in vitro selection and uses thereof
US20050064435A1 (en) * 2003-09-24 2005-03-24 Xing Su Programmable molecular barcodes
EP1663199B1 (de) * 2003-09-25 2013-04-03 Tel Aviv University Future Technology Development L.P. Zusammensetzungen und diese verwendende verfahren zur behandlung von amyloid-bedingten erkrankungen
EP1678324A4 (de) * 2003-09-30 2007-10-31 Hospital For Sick Children Verfahren zum in-situ-nachweis von proteinen unter verwendung von aptameren
US7803624B2 (en) 2003-09-30 2010-09-28 Cytyc Corporation Automated cytological sample classification
US7625707B2 (en) * 2003-10-02 2009-12-01 Ramot At Tel Aviv University Ltd. Antibacterial agents and methods of identifying and utilizing same
US7132298B2 (en) * 2003-10-07 2006-11-07 Hewlett-Packard Development Company, L.P. Fabrication of nano-object array
US7223611B2 (en) * 2003-10-07 2007-05-29 Hewlett-Packard Development Company, L.P. Fabrication of nanowires
EP1682662A1 (de) * 2003-11-10 2006-07-26 Noxxon Pharma AG Bioaktives ghrelin spezifisch bindende nukleinsäuren
US20070110719A1 (en) 2003-11-14 2007-05-17 Holm Per S Novel use of adenoviruses and nucleic acids that code for said viruses
WO2005051174A2 (en) * 2003-11-21 2005-06-09 The Trustees Of Columbia University In The City Of New York Nucleic acid aptamer-based compositions and methods
US20050123932A1 (en) * 2003-12-09 2005-06-09 Mekbib Astatke Nucleic acid-chelating agent conjugates
GB0328448D0 (en) * 2003-12-09 2004-01-14 Univ Leeds Agents for the regulation of transcription via zinc finger proteins
CN101208437B (zh) * 2003-12-12 2012-07-04 圣路易斯大学 检测大分子和其它分析物的生物传感器
US7361410B2 (en) * 2003-12-29 2008-04-22 Intel Corporation External modification of composite organic inorganic nanoclusters comprising raman active organic compound
US20080076119A9 (en) * 2003-12-29 2008-03-27 Lei Sun Composite organic inorganic nanoclusters
US20050147963A1 (en) * 2003-12-29 2005-07-07 Intel Corporation Composite organic-inorganic nanoparticles and methods for use thereof
US20050191665A1 (en) * 2003-12-29 2005-09-01 Xing Su Composite organic-inorganic nanoclusters
US7803931B2 (en) 2004-02-12 2010-09-28 Archemix Corp. Aptamer therapeutics useful in the treatment of complement-related disorders
PT1727567E (pt) 2004-02-12 2013-10-14 Archemix Llc Terapêuticas com aptâmeros úteis no tratamento de desordens relacionadas com o complemento
US7910297B2 (en) * 2004-02-27 2011-03-22 Operational Technologies Corporation Therapeutic nucleic acid-3' -conjugates
US8318920B2 (en) * 2004-02-27 2012-11-27 Operational Technologies Corporation Therapeutic nucleic acid-3′-conjugates
US8389710B2 (en) 2004-02-27 2013-03-05 Operational Technologies Corporation Therapeutic nucleic acid-3′-conjugates
US20070066550A1 (en) * 2004-03-05 2007-03-22 Diener John L Aptamers to the human IL-12 cytokine family and their use as autoimmune disease therapeutics
US20060193821A1 (en) * 2004-03-05 2006-08-31 Diener John L Aptamers to the human IL-12 cytokine family and their use as autoimmune disease therapeutics
JP2007530586A (ja) 2004-03-25 2007-11-01 ザ ファインスタイン インスティテュート フォー メディカル リサーチ 神経性止血法
US10912712B2 (en) 2004-03-25 2021-02-09 The Feinstein Institutes For Medical Research Treatment of bleeding by non-invasive stimulation
US20050221339A1 (en) 2004-03-31 2005-10-06 Medical Research Council Harvard University Compartmentalised screening by microfluidic control
US7407738B2 (en) * 2004-04-02 2008-08-05 Pavel Kornilovich Fabrication and use of superlattice
US7794713B2 (en) 2004-04-07 2010-09-14 Lpath, Inc. Compositions and methods for the treatment and prevention of hyperproliferative diseases
US8470315B2 (en) * 2004-04-13 2013-06-25 Quintessence Biosciences, Inc. Non-natural ribonuclease conjugates as cytotoxic agents
US20080214489A1 (en) * 2004-04-19 2008-09-04 Anthony Dominic Keefe Aptamer-mediated intracellular delivery of oligonucleotides
US20050239134A1 (en) * 2004-04-21 2005-10-27 Board Of Regents, The University Of Texas System Combinatorial selection of phosphorothioate single-stranded DNA aptamers for TGF-beta-1 protein
PL1745062T3 (pl) * 2004-04-22 2014-10-31 Regado Biosciences Inc Ulepszone modulatory czynników krzepnięcia
US7579450B2 (en) 2004-04-26 2009-08-25 Archemix Corp. Nucleic acid ligands specific to immunoglobulin E and their use as atopic disease therapeutics
US7247531B2 (en) 2004-04-30 2007-07-24 Hewlett-Packard Development Company, L.P. Field-effect-transistor multiplexing/demultiplexing architectures and methods of forming the same
US7683435B2 (en) 2004-04-30 2010-03-23 Hewlett-Packard Development Company, L.P. Misalignment-tolerant multiplexing/demultiplexing architectures
DE102004021707A1 (de) * 2004-04-30 2005-11-24 Cytotools Gmbh Verfahren zur Isolierung von spezifischen Molekülen, die hochselektiv an ausgewählte Zielmoleküle binden
AU2005321469B2 (en) 2004-05-05 2012-04-05 Silence Therapeutics Gmbh Lipid complexes coated with peg and their use
US20060024814A1 (en) * 2004-07-29 2006-02-02 Peters Kevin F Aptamer-functionalized electrochemical sensors and methods of fabricating and using the same
EP1781310B1 (de) 2004-08-02 2015-10-14 Ramot at Tel Aviv University Ltd. Artikel von peptidnanostrukturen und herstellungsverfahren dafür
US20070048797A1 (en) * 2004-08-11 2007-03-01 Xing Su Composite organic inorganic nanoclusters as carriers and identifiers of tester molecules
US7732479B2 (en) 2004-08-19 2010-06-08 Tel Aviv University Future Technology Development L.P. Compositions for treating amyloid associated diseases
US20060040258A1 (en) * 2004-08-23 2006-02-23 Huiyan Guo Water-soluble conjugates and methods of preparation
CA2578205A1 (en) * 2004-08-25 2006-03-30 The Regents Of The University Of Michigan Partially acetylated dendrimers and related methods of use
US20060046311A1 (en) * 2004-08-26 2006-03-02 Intel Corporation Biomolecule analysis using Raman surface scanning
US7776547B2 (en) * 2004-08-26 2010-08-17 Intel Corporation Cellular analysis using Raman surface scanning
US7566701B2 (en) 2004-09-07 2009-07-28 Archemix Corp. Aptamers to von Willebrand Factor and their use as thrombotic disease therapeutics
JP2008512097A (ja) 2004-09-07 2008-04-24 アーケミックス コーポレイション アプタマー医薬品化学
EP1789096A4 (de) * 2004-09-07 2009-07-08 Archemix Corp Aptamere für den von-willebrand-faktor und ihre verwendung als therapeutika für thrombotische erkrankungen
US7786086B2 (en) * 2004-09-08 2010-08-31 Ramot At Tel-Aviv University Ltd. Peptide nanostructures containing end-capping modified peptides and methods of generating and using the same
US7659091B2 (en) 2004-09-21 2010-02-09 Nourheart, Inc. Diagnostic marker
US7968287B2 (en) 2004-10-08 2011-06-28 Medical Research Council Harvard University In vitro evolution in microfluidic systems
MY159370A (en) 2004-10-20 2016-12-30 Coley Pharm Group Inc Semi-soft-class immunostimulatory oligonucleotides
CA2580363A1 (en) * 2004-10-28 2006-05-11 Idexx Laboratories, Inc. Compositions for controlled delivery of pharmaceutically active compounds
EP2436391A3 (de) 2004-11-02 2012-07-04 Archemix LLC Stabilisierte Aptamere für einen aus Plättchen gewonnenen Wachstumsfaktor und ihre Verwendung als Krebstherapiemittel
US9492400B2 (en) 2004-11-04 2016-11-15 Massachusetts Institute Of Technology Coated controlled release polymer particles as efficient oral delivery vehicles for biopharmaceuticals
EP2298410B1 (de) 2004-12-27 2013-10-09 The Feinstein Institute for Medical Research Behandlung von entzündlichen Erkrankungen durch elektrische Stimulation des Vagusnervs
US11207518B2 (en) 2004-12-27 2021-12-28 The Feinstein Institutes For Medical Research Treating inflammatory disorders by stimulation of the cholinergic anti-inflammatory pathway
US20060147941A1 (en) * 2004-12-30 2006-07-06 Intel Corporation Methods and apparatus for SERS assay of biological analytes
US9505846B2 (en) * 2005-01-28 2016-11-29 Life Technologies Corporation Multi-component inhibitors of nucleic acid polymerases
US7375012B2 (en) * 2005-02-28 2008-05-20 Pavel Kornilovich Method of forming multilayer film
US20100196509A1 (en) 2005-02-28 2010-08-05 Jonathan Braun Methods for Diagnosis and Treatment of Endometrial Cancer
EP1863828A4 (de) * 2005-03-07 2010-10-13 Archemix Corp Stabilisierte aptamere für psma und ihre verwendung als prostatakrebstherapeutika
AU2006223498A1 (en) 2005-03-10 2006-09-21 Genentech, Inc. Methods and compositions for modulating vascular integrity
US20060205090A1 (en) * 2005-03-14 2006-09-14 Newton Michael W Water-soluble conjugates for electrochemical detection
WO2006102540A2 (en) * 2005-03-24 2006-09-28 Syracuse University Elucidation of high affinity, high specificity oligonucleotides and derivatized oligonucleotide sequences for target recognition
US20100036106A1 (en) * 2005-03-30 2010-02-11 Nec Soft, Ltd. High-Affinity RNA Aptamer Molecule Against Glutathione-S-Transferase Protein
UY29460A1 (es) * 2005-04-08 2006-11-30 Noxxon Pharma Ag Acidos nucleicos de union a ghrelin
US8318906B2 (en) 2005-04-15 2012-11-27 The Regents Of The University Of California EMP2 antibodies and their therapeutic uses
DE102005022057B3 (de) * 2005-05-09 2007-02-08 Analyticon Biotechnologies Ag Verfahren zur Herstellung von Liganden, Liganden und Test-Kit
WO2006125094A2 (en) * 2005-05-18 2006-11-23 Board Of Regents, The University Of Texas System Combinatorial selection of phosphorothioate aptamers for rnases
US8956857B2 (en) 2005-06-06 2015-02-17 Mediomics, Llc Three-component biosensors for detecting macromolecules and other analytes
US7795009B2 (en) * 2005-06-15 2010-09-14 Saint Louis University Three-component biosensors for detecting macromolecules and other analytes
WO2006135527A2 (en) 2005-06-10 2006-12-21 Saint Louis University Methods for the selection of aptamers
US7811809B2 (en) * 2005-06-15 2010-10-12 Saint Louis University Molecular biosensors for use in competition assays
WO2007005426A2 (en) * 2005-06-29 2007-01-11 Rules-Based Medicine, Inc. Methods and kits for the diagnosis of acute coronary syndrome
CA2613442C (en) 2005-06-30 2016-08-23 Archemix Corp. Materials and methods for the generation of fully 2'-modified nucleic acid transcripts
US8101385B2 (en) 2005-06-30 2012-01-24 Archemix Corp. Materials and methods for the generation of transcripts comprising modified nucleotides
CA2614145A1 (en) 2005-07-05 2007-01-11 Ribomic Inc. Nucleic acid capable of binding to immunoglobulin g and use thereof
US7662571B2 (en) 2005-07-14 2010-02-16 Nourheart Inc. Mitochondrial markers of ischemia
US20100254901A1 (en) * 2005-07-28 2010-10-07 Smith Cassandra L Compositions comprising nucleic acid aptamers
US20070041934A1 (en) * 2005-08-12 2007-02-22 Regents Of The University Of Michigan Dendrimer based compositions and methods of using the same
EA016577B1 (ru) 2005-09-26 2012-06-29 Медарекс, Инк. Конъюгаты антитело-лекарство и их применение
US10004828B2 (en) 2005-10-11 2018-06-26 Romat at Tel-Aviv University Ltd. Self-assembled Fmoc-ff hydrogels
GB0521139D0 (en) 2005-10-18 2005-11-23 Univ Sheffield Therapeutic agent
EP1943518A4 (de) * 2005-11-03 2010-04-21 Lohocla Res Corp Diagnostische tests von drogenmissbrauch
US7879212B2 (en) * 2005-11-03 2011-02-01 Ramot At Tel-Aviv University Ltd. Peptide nanostructure-coated electrodes
JP2009517340A (ja) 2005-11-04 2009-04-30 バイオジェン・アイデック・エムエイ・インコーポレイテッド ドーパミン作動性ニューロンの神経突起成長および生存を促進するための方法
US7754679B2 (en) * 2005-11-16 2010-07-13 Idexx Laboratories, Inc. Pharmaceutical compositions for the administration of aptamers
US8017159B2 (en) * 2005-11-16 2011-09-13 Idexx Laboratories, Inc. Phospholipid gel compositions for delivery of aptamers and methods of treating conditions using same
US8114440B2 (en) * 2005-11-16 2012-02-14 Idexx Laboratories Inc. Pharmaceutical compositions for the administration of aptamers
JP5119444B2 (ja) * 2005-12-06 2013-01-16 国立大学法人 東京大学 多目的アシル化触媒とその用途
US9267937B2 (en) 2005-12-15 2016-02-23 Massachusetts Institute Of Technology System for screening particles
EP2674440B1 (de) 2005-12-16 2019-07-03 IBC Pharmaceuticals, Inc. Polyvalente bioaktive anordnungen auf immunglobulinbasis
US20100061932A1 (en) 2005-12-30 2010-03-11 Evonik Roehm Gmbh Peptides useful as cell-penetrating peptides
US20070155022A1 (en) * 2005-12-30 2007-07-05 Mineo Yamakawa Degenerate binding detection and protein identification using Raman spectroscopy nanoparticle labels
US20070239483A1 (en) * 2006-01-09 2007-10-11 Biophysical Corporation Methods for individualized health assessment service
WO2007081385A2 (en) 2006-01-11 2007-07-19 Raindance Technologies, Inc. Microfluidic devices and methods of use in the formation and control of nanoreactors
ES2538038T3 (es) 2006-01-17 2015-06-16 Somalogic, Inc. Análisis multiplexado de muestras de ensayo
PT1981902E (pt) 2006-01-27 2015-11-02 Biogen Ma Inc Antagonistas dos recetores nogo
US7922000B2 (en) * 2006-02-15 2011-04-12 Miraial Co., Ltd. Thin plate container with a stack of removable loading trays
US8460879B2 (en) 2006-02-21 2013-06-11 The Trustees Of Tufts College Methods and arrays for target analyte detection and determination of target analyte concentration in solution
WO2007103549A2 (en) 2006-03-08 2007-09-13 Archemix Corp. Complement binding aptamers and anti-c5 agents useful in the treatment of ocular disorders
EP1996942A1 (de) * 2006-03-10 2008-12-03 Tethys Bioscience, Inc. Multiplex-protein-fraktionierung
JP4984990B2 (ja) * 2006-03-28 2012-07-25 富士通株式会社 機能性分子の製造方法
US20070231855A1 (en) * 2006-03-28 2007-10-04 Fujitsu Limited Functional molecule and manufacturing method therefor
ES2776100T3 (es) 2006-03-31 2020-07-29 Massachusetts Inst Technology Sistema para el suministro dirigido de agentes terapéuticos
AU2007241370A1 (en) 2006-04-20 2007-11-01 Silence Therapeutics Ag. Lipoplex formulations for specific delivery to vascular endothelium
US20080020475A1 (en) * 2006-05-05 2008-01-24 Rules-Based Medicine, Inc Methods and kits for the diagnosis of hypothyroidism
US9074242B2 (en) 2010-02-12 2015-07-07 Raindance Technologies, Inc. Digital analyte analysis
US9562837B2 (en) 2006-05-11 2017-02-07 Raindance Technologies, Inc. Systems for handling microfludic droplets
EP2530168B1 (de) 2006-05-11 2015-09-16 Raindance Technologies, Inc. Mikrofluidische Vorrichtungen
DE202006007590U1 (de) 2006-05-12 2006-12-14 Osaka University Verwendung einer Zusammensetzung, die Sema7A- und VLA-1-Interaktion inhibiert, zum Behandeln von Cytokin-vermittelten Erkrankungen
CN101573141B (zh) 2006-05-15 2016-05-04 麻省理工学院 用于功能性颗粒的聚合物
US7862812B2 (en) 2006-05-31 2011-01-04 Lpath, Inc. Methods for decreasing immune response and treating immune conditions
US20070292397A1 (en) * 2006-06-19 2007-12-20 Mcnulty Amy K Method for the detection and neutralization of bacteria
EP2044097A4 (de) * 2006-06-23 2010-10-06 Quintessence Biosciences Inc Modifizierte ribonukleasen
WO2007150030A2 (en) 2006-06-23 2007-12-27 Massachusetts Institute Of Technology Microfluidic synthesis of organic nanoparticles
US20080008694A1 (en) 2006-07-05 2008-01-10 Elgebaly Salwa A Methods to prevent and treat diseases
WO2008010991A2 (en) * 2006-07-17 2008-01-24 Quintessence Biosciences, Inc. Methods and compositions for the treatment of cancer
WO2008011157A2 (en) 2006-07-20 2008-01-24 The General Hospital Corporation Methods, compositions, and kits for the selective activation of protoxins through combinatorial targeting
US7838242B2 (en) * 2006-07-21 2010-11-23 Hitachi Chemical Co., Ltd. Nucleic acid ligands capable of binding to internalin B or internalin A
JP2009544281A (ja) 2006-07-21 2009-12-17 サイレンス・セラピューティクス・アーゲー プロテインキナーゼ３の発現を阻害するための手段
US7645582B2 (en) * 2006-07-21 2010-01-12 Hitachi Chemical Co., Ltd. Aptamers that bind to listeria surface proteins
US20080031903A1 (en) * 2006-07-27 2008-02-07 Andrea Gambotto Method of treating ocular infections
JP5635772B2 (ja) * 2006-08-01 2014-12-03 ジェン−プロウブ インコーポレイテッド 核酸の非特異的標的の捕捉方法
US20100129870A1 (en) 2006-08-03 2010-05-27 Nec Soft, Ltd. Method for obtaining oligonucleotide
US9012390B2 (en) 2006-08-07 2015-04-21 Raindance Technologies, Inc. Fluorocarbon emulsion stabilizing surfactants
US20080070802A1 (en) * 2006-08-23 2008-03-20 Moerschell Richard P Directed heterobifunctional linkers
EP2289906A1 (de) 2006-09-15 2011-03-02 Intercell AG Borrelia-Antigene
US20100136537A1 (en) * 2006-10-10 2010-06-03 The Regents Of The University Of Michigan Photoreceptor precursor cells
JP4841396B2 (ja) 2006-10-18 2011-12-21 Ｎｅｃソフト株式会社 塩基配列の同定装置、核酸分子の二次構造取得装置、塩基配列の同定方法、核酸分子の二次構造取得方法、プログラム及び記録媒体
EP1913955A1 (de) 2006-10-19 2008-04-23 Gerhard, Markus Neue Methode zur Behandlung von Infektionen durch H. pylori
WO2008064304A2 (en) * 2006-11-22 2008-05-29 Trana Discovery, Inc. Compositions and methods for the identification of inhibitors of protein synthesis
TW200831538A (en) 2006-12-19 2008-08-01 Genentech Inc VEGF-specific antagonists for adjuvant and neoadjuvant therapy and the treatment of early stage tumors
WO2008089059A1 (en) * 2007-01-12 2008-07-24 Rules-Based Medicine, Inc. Methods and kits for the diagnosis of galactosemia
US7947447B2 (en) 2007-01-16 2011-05-24 Somalogic, Inc. Method for generating aptamers with improved off-rates
US7964356B2 (en) 2007-01-16 2011-06-21 Somalogic, Inc. Method for generating aptamers with improved off-rates
US20110136099A1 (en) * 2007-01-16 2011-06-09 Somalogic, Inc. Multiplexed Analyses of Test Samples
US8975026B2 (en) 2007-01-16 2015-03-10 Somalogic, Inc. Method for generating aptamers with improved off-rates
US7855054B2 (en) * 2007-01-16 2010-12-21 Somalogic, Inc. Multiplexed analyses of test samples
US9725713B1 (en) 2007-01-22 2017-08-08 Steven A Benner In vitro selection with expanded genetic alphabets
US8586303B1 (en) 2007-01-22 2013-11-19 Steven Albert Benner In vitro selection with expanded genetic alphabets
EP2111553B1 (de) 2007-01-24 2018-09-19 Carnegie Mellon University Optische biosensoren
US8772046B2 (en) 2007-02-06 2014-07-08 Brandeis University Manipulation of fluids and reactions in microfluidic systems
WO2008098165A2 (en) 2007-02-09 2008-08-14 Massachusetts Institute Of Technology Oscillating cell culture bioreactor
US20080255766A1 (en) * 2007-02-16 2008-10-16 Rules-Based Medicine, Inc. Methods and kits for the diagnosis of sickle cell
WO2008109797A1 (en) * 2007-03-08 2008-09-12 Rules-Based Medicine, Inc. Methods for rapid disease screening
DE102007011702A1 (de) 2007-03-08 2008-09-11 Rheinische Friedrich-Wilhelms Universität Aptamer-basierte Reagenzien
US20100291562A1 (en) * 2007-04-04 2010-11-18 Michael Adler Method for the detection of an analyte in biological matrix
WO2008124639A2 (en) 2007-04-04 2008-10-16 Massachusetts Institute Of Technology Poly (amino acid) targeting moieties
WO2008124634A1 (en) 2007-04-04 2008-10-16 Massachusetts Institute Of Technology Polymer-encapsulated reverse micelles
US20080248958A1 (en) * 2007-04-05 2008-10-09 Hollenbach Andrew D System for pulling out regulatory elements in vitro
US8592221B2 (en) 2007-04-19 2013-11-26 Brandeis University Manipulation of fluids, fluid components and reactions in microfluidic systems
US20090088376A1 (en) * 2007-04-19 2009-04-02 The Regents Of The University Of Michigan Dendrimer based compositions and methods of using the same
CA2684998A1 (en) 2007-04-30 2009-01-29 Nanogen, Inc. Multianalyte assay
CN102015754A (zh) 2007-05-02 2011-04-13 英特塞尔股份公司 克雷伯菌（Klebsiella）抗原
EP2511291A3 (de) 2007-06-18 2012-11-07 Intercell AG Chlamydia-Antigene
US8828960B2 (en) * 2007-07-17 2014-09-09 Idexx Laboratories, Inc. Amino acid vitamin ester compositions for controlled delivery of pharmaceutically active compounds
EP2489743B1 (de) 2007-07-17 2015-01-07 Somalogic, Inc. Aptamere mit 5-(N-Naphthyl)-substituiertem Uridin
FR2920024B1 (fr) 2007-08-14 2012-12-14 Lfb Biotechnologies Procede de purification ou de detection d'une proteine cible
US8916135B2 (en) 2007-08-22 2014-12-23 Colorado School Of Mines Lanthanide nanoparticle conjugates and uses thereof
WO2009029614A1 (en) 2007-08-27 2009-03-05 The Feinstein Institute For Medical Research Devices and methods for inhibiting granulocyte activation by neural stimulation
DE102007041476B4 (de) 2007-08-31 2017-03-30 Rheinische Friedrich-Wilhelms-Universität Bonn Aptamere, die an ein an der Hämostase beteiligtes Zielmolekül binden
US8198039B2 (en) * 2007-09-04 2012-06-12 University of Pittsburgh—of the Commonwealth System of Higher Education Biosensors and related methods
US8183221B2 (en) 2007-09-05 2012-05-22 Medtronic, Inc. Suppression of SCN9A gene expression and/or function for the treatment of pain
US20090068669A1 (en) * 2007-09-12 2009-03-12 Elias Georges Slc9a3r1 directed diagnostics for neoplastic disease
EP2197455A4 (de) * 2007-09-14 2010-10-20 Univ North Carolina State Zusammensetzungen und verfahren zur identifizierung von inhibitoren von retroviralen infektionen
AR068542A1 (es) * 2007-09-24 2009-11-18 Performance Plants Inc Plantas que tienen biomasa aumentada
EP2197454A4 (de) * 2007-09-25 2012-07-04 Idexx Lab Inc Pharmazeutische zusammensetzungen zur verabreichung von oligonucleotiden
CN104502579B (zh) 2007-10-02 2018-04-13 赛拉诺斯知识产权有限责任公司 模块化现场护理装置及其应用
US9200382B2 (en) * 2007-10-05 2015-12-01 The Regents Of The University Of California High-stringency screening of target-binding partners using a microfluidic device
EP2045326A1 (de) * 2007-10-05 2009-04-08 Bayer CropScience AG Verfahren zum Identifizieren des Interaktionspartners eines Wirkstoffes
WO2009048909A1 (en) * 2007-10-08 2009-04-16 Quintessence Biosciences, Inc. Compositions and methods for ribonuclease-based therapies
CN105770878A (zh) 2007-10-12 2016-07-20 麻省理工学院 疫苗纳米技术
US20090163437A1 (en) * 2007-10-16 2009-06-25 Regado Biosciences, Inc. Steady-state subcutaneous administration of aptamers
CN102277353B (zh) † 2007-10-22 2014-12-31 卡里斯生命科学瑞士控股有限责任公司 选择适配体的方法
US8906700B2 (en) 2007-11-06 2014-12-09 Ambergen, Inc. Methods and compositions for phototransfer
WO2009064424A1 (en) * 2007-11-13 2009-05-22 Rational Affinity Devices, L.L.C. Tunable affinity ligands for the separation and detection of target substances
WO2010070380A2 (en) 2007-12-03 2010-06-24 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health Of Human Services, National Institutes Of Health Doc1 compositions and methods for treating cancer
EP3561494B1 (de) 2007-12-06 2022-03-02 Genalyte, Inc. VERFAHREN ZUM IDENTIFIZIEREN EINER SEQUENZ VON NUKLEOTIDEN IN EINER UNBEKANNTEN SPEZIES VON NUKLEINSÄURE
UND VORRICHTUNG ZUR DURCHFÜHRUNG DES VERFAHRENS
US8865401B2 (en) 2007-12-14 2014-10-21 The Johns Hopkins University Purification and concentration of proteins and DNA from a complex sample using isotachophoresis and a device to perform the purification
WO2009078939A1 (en) * 2007-12-17 2009-06-25 Brown University Methods for identifying nucleotide ligands
JP5550182B2 (ja) 2008-01-07 2014-07-16 ルミネックス コーポレーション 複合試料マトリクスからの細胞の単離および計数の方法
BRPI0906492A2 (pt) 2008-01-11 2015-12-01 Synovex Corp antagonistas da caderina-11 e métodos para o tratamento de doenças inflamatórias das articulações
US20090233295A1 (en) * 2008-01-29 2009-09-17 Elias Georges Trim59 directed diagnostics for neoplastic disease
EP2245466A2 (de) 2008-02-04 2010-11-03 Banyan Biomarkers, Inc. Verfahren zur diagnose oder behandlung einer gehirnverletzung
WO2009151687A2 (en) 2008-03-12 2009-12-17 The Regents Of The University Of Michigan Dendrimer conjugates
CN102066562A (zh) * 2008-03-12 2011-05-18 雪城大学 结构限定的适配子的直接选择
US20100048912A1 (en) 2008-03-14 2010-02-25 Angela Brodie Novel C-17-Heteroaryl Steroidal CYP17 Inhibitors/Antiandrogens, In Vitro Biological Activities, Pharmacokinetics and Antitumor Activity
US9115352B2 (en) 2008-03-31 2015-08-25 Sloning Biotechnology Gmbh Method for the preparation of a nucleic acid library
US9211409B2 (en) 2008-03-31 2015-12-15 The Feinstein Institute For Medical Research Methods and systems for reducing inflammation by neuromodulation of T-cell activity
US9662490B2 (en) 2008-03-31 2017-05-30 The Feinstein Institute For Medical Research Methods and systems for reducing inflammation by neuromodulation and administration of an anti-inflammatory drug
EP2279412B1 (de) 2008-04-09 2017-07-26 Genentech, Inc. Neue zusammensetzungen und verfahren zur behandlung von immunkrankheiten
JP2011521626A (ja) 2008-05-02 2011-07-28 エピセンター テクノロジーズ コーポレーション Ｒｎａポリホスファターゼの組成物、キットおよびそれらの使用
US20110229498A1 (en) 2008-05-08 2011-09-22 The Johns Hopkins University Compositions and methods for modulating an immune response
US20120003749A1 (en) * 2008-05-21 2012-01-05 Nec Soft, Ltd. Nucleic acid molecule capable of binding to 2,4,6-trinitrophenyl skeleton, method for detecting compound having 2,4,6-trinitrophenyl skeleton using the nucleic acid molecule, and use of the nucleic acid molecule
MX2010013123A (es) 2008-06-06 2011-01-14 Danisco Inc Alfa-amilasas variantes de bacillus subtilis y metodos de uso de las mismas.
US8722638B2 (en) * 2008-06-20 2014-05-13 Children's Medical Center Corporation Methods for the modulation of angiogenesis
EP2316935B1 (de) * 2008-07-14 2016-08-31 The University of Tokyo Aptamer gegen il-17 und verwendung davon
US8703416B2 (en) 2008-07-17 2014-04-22 Somalogic, Inc. Method for purification and identification of sperm cells
US8329647B2 (en) 2008-07-17 2012-12-11 Ikfe Institut Fur Klinische Forschung Und Entwicklung Gmbh Method of treating a subject according to biomarkers for insulin resistance
AU2009272369B2 (en) 2008-07-17 2016-04-14 Ikfe Institut Fur Klinische Forschung Und Entwicklung Gmbh Biomarkers for cardiodiabetes
EP4047367A1 (de) 2008-07-18 2022-08-24 Bio-Rad Laboratories, Inc. Verfahren zum nachweis von zielanalyten unter verwendung von tropfenbibliotheken
US20110143375A1 (en) 2008-08-11 2011-06-16 Banyan Blomakers, Inc. Biomarker detection process and assay of neurological condition
WO2010096464A1 (en) 2009-02-18 2010-08-26 Boyes Stephen G Gold/lanthanide nanoparticle conjugates and uses thereof
US20100068729A1 (en) * 2008-09-12 2010-03-18 Rules-Based Medicine, Inc. Method and kits for the diagnosis of diabetes
MX2011003144A (es) 2008-09-24 2011-05-19 Ribomic Inc Aptamero para factor de crecimiento de nervio y uso del mismo.
CA2776044A1 (en) * 2008-09-29 2010-04-01 Trana Discovery, Inc. Screening methods for identifying specific staphylococcus aureus inhibitors
US8889635B2 (en) 2008-09-30 2014-11-18 The Regents Of The University Of Michigan Dendrimer conjugates
JP2012504423A (ja) 2008-10-01 2012-02-23 クインテッセンス バイオサイエンシズ，インコーポレーテッド 治療用リボヌクレアーゼ
WO2010042823A1 (en) 2008-10-09 2010-04-15 Northeastern Universtiy Multifunctional self-assembling polymeric nanosystems
WO2010042933A2 (en) 2008-10-10 2010-04-15 Northwestern University Inhibition and treatment of prostate cancer metastasis
US8591905B2 (en) 2008-10-12 2013-11-26 The Brigham And Women's Hospital, Inc. Nicotine immunonanotherapeutics
US8343497B2 (en) 2008-10-12 2013-01-01 The Brigham And Women's Hospital, Inc. Targeting of antigen presenting cells with immunonanotherapeutics
US8343498B2 (en) 2008-10-12 2013-01-01 Massachusetts Institute Of Technology Adjuvant incorporation in immunonanotherapeutics
US8277812B2 (en) 2008-10-12 2012-10-02 Massachusetts Institute Of Technology Immunonanotherapeutics that provide IgG humoral response without T-cell antigen
AU2009308293B2 (en) 2008-10-22 2015-02-05 Genentech, Inc. Modulation of axon degeneration
EP2347247B1 (de) 2008-10-27 2019-06-26 Genalyte, Inc. Auf optischer sondierung und optischem abtasten basierende biosensoren
AU2009340423B2 (en) 2008-10-29 2014-07-24 Bg Medicine, Inc. Galectin-3 immunoassay
ES2631507T3 (es) 2008-10-29 2017-08-31 China Synthetic Rubber Corporation Procedimientos y agentes para el diagnóstico y tratamiento del carcinoma hepatocelular
WO2010054321A2 (en) 2008-11-07 2010-05-14 The Regents Of The University Of Michigan Methods of treating autoimmune disorders and/or inflammatory disorders
US8412338B2 (en) 2008-11-18 2013-04-02 Setpoint Medical Corporation Devices and methods for optimizing electrode placement for anti-inflamatory stimulation
CN102317779A (zh) 2008-11-21 2012-01-11 圣路易大学 检测目标物多个表位的生物感应器
CA2782776A1 (en) 2008-12-04 2010-06-10 Ikfe Gmbh Biomarkers for atherosclerosis
US20110118134A1 (en) 2008-12-11 2011-05-19 Ikfe Gmbh Biomarkers for insulin sensitizer drug response
CA2688174C (en) 2008-12-19 2018-08-07 F. Hoffmann-La Roche Ag Dry composition of reaction compounds with stabilized polymerase
WO2010076655A1 (en) 2008-12-30 2010-07-08 Ikfe Gmbh Biomarkers for adipose tissue activity
US20100210541A1 (en) 2009-01-07 2010-08-19 Andreas Pfuetzner Biomarkers for Appetite Regulation
ES2552087T3 (es) 2009-02-05 2015-11-25 Tokai Pharmaceuticals, Inc. Nuevos profármacos de inhibidores de CYP17 esteroidales/antiandrógenos
EP2405938A2 (de) 2009-02-13 2012-01-18 Intercell AG Nicht typisierbare haemophilus influenza-antigene
EP2396036B1 (de) 2009-02-13 2017-06-28 Immunomedics, Inc. Immunokonjugate mit einer intrazellulär spaltbaren verknüpfung
JP2012518072A (ja) 2009-02-18 2012-08-09 カーネギー メロン ユニバーシティ 明検出のためのクエンチャー付加デンドリマー色素
FR2942232B1 (fr) 2009-02-19 2015-03-13 Lfb Biotechnologies Moyens pour la purification d'une proteine de la coagulation et procedes pour sa mise en oeuvre
AU2010224172B2 (en) 2009-03-11 2016-01-21 Promedior, Inc. Treatment methods for autoimmune disorders
CA2754961C (en) 2009-03-11 2018-04-10 Promedior, Inc. Treatment and diagnostic methods for hypersensitive disorders
EP3415235A1 (de) 2009-03-23 2018-12-19 Raindance Technologies Inc. Manipulation von mikrofluidiktröpfchen
JP5561755B2 (ja) 2009-04-01 2014-07-30 Ｎｅｃソリューションイノベータ株式会社 Ｓｅｌｅｘ法用のプライマーの設計方法、プライマーの製造方法、アプタマーの製造方法、プライマーの設計装置、プライマー設計用コンピュータプログラムおよび記録媒体
WO2010118435A2 (en) 2009-04-10 2010-10-14 Tufts Medical Center, Inc. Par-1 activation by metalloproteinase-1 (mmp-1)
TWI578992B (zh) * 2009-04-30 2017-04-21 諾克森製藥股份有限公司 與鐵調節激素（ｈｅｐｃｉｄｉｎ）結合之核酸類
US9211410B2 (en) 2009-05-01 2015-12-15 Setpoint Medical Corporation Extremely low duty-cycle activation of the cholinergic anti-inflammatory pathway to treat chronic inflammation
US8996116B2 (en) 2009-10-30 2015-03-31 Setpoint Medical Corporation Modulation of the cholinergic anti-inflammatory pathway to treat pain or addiction
EP2427205A2 (de) 2009-05-04 2012-03-14 INSERM - Institut National de la Santé et de la Recherche Médicale Par2-agonisten zur verwendung bei der behandlung oder prävention von infektionen mit dem grippevirus typ a
CA2760774A1 (en) * 2009-05-05 2010-11-11 Altermune Technologies, Llc Chemically programmable immunity
US20100291706A1 (en) 2009-05-15 2010-11-18 Millipore Corporation Dye conjugates and methods of use
WO2010141365A2 (en) 2009-06-01 2010-12-09 Cornell University Integrated optofluidic system using microspheres
US8318923B2 (en) 2009-06-03 2012-11-27 Regado Biosciences, Inc. Nucleic acid modulators of glycoprotein VI
US9187757B2 (en) 2009-06-05 2015-11-17 University Of Florida Research Foundation, Inc. Isolation and targeted suppression of lignin biosynthetic genes
CN102573986B (zh) 2009-06-09 2016-01-20 赛博恩特医疗器械公司 用于无导线刺激器的具有袋部的神经封套
TWI532842B (zh) 2009-06-11 2016-05-11 力博美科股份有限公司 針對凝乳酶之適體及其用途
EP2442820B1 (de) 2009-06-19 2015-09-23 INSERM - Institut National de la Santé et de la Recherche Médicale Basigin-agonisten zur behandlung von neurodegenerativen erkrankungen
AU2010262952B2 (en) 2009-06-19 2016-01-07 Banyan Biomarkers, Inc. Biomarker assay of neurological condition
EP2445334A1 (de) 2009-06-26 2012-05-02 INSERM (Institut National de la Santé et de la Recherche Médicale) Nicht humane tiermodelle für verbesserten netzhautgefässpermeabilität
AU2013203588C1 (en) * 2009-07-09 2016-06-30 Somalogic Operating Co., Inc. Method for generating aptamers with improved off-rates
TW201106972A (en) 2009-07-27 2011-03-01 Genentech Inc Combination treatments
GB0913258D0 (en) 2009-07-29 2009-09-02 Dynex Technologies Inc Reagent dispenser
US9523701B2 (en) 2009-07-29 2016-12-20 Dynex Technologies, Inc. Sample plate systems and methods
FR2948665B1 (fr) 2009-07-31 2011-09-23 Lfb Biotechnologies Procede pour la purification de proteines de la coagulation a domaine gla actives
FR2948664B1 (fr) 2009-07-31 2013-11-01 Lfb Biotechnologies Procede pour la purification de proteines de la coagulation a domaine gla
EP2462238B1 (de) 2009-08-07 2013-07-17 Ohmx Corporation Enzyme-gesteuerter redox-ändernder chemischer eliminierungs- (e-trace-) immunassay
GB0914318D0 (en) 2009-08-14 2009-09-30 Medical Res Council Method
US9024766B2 (en) * 2009-08-28 2015-05-05 The Invention Science Fund, Llc Beverage containers with detection capability
US8898069B2 (en) * 2009-08-28 2014-11-25 The Invention Science Fund I, Llc Devices and methods for detecting an analyte in salivary fluid
WO2011023824A2 (en) 2009-08-31 2011-03-03 INSERM (Institut National de la Santé et de la Recherche Médicale) Estrogen receptor modulators for the treatment of diseases involving plasmacytoid dendritic cells
WO2011026111A1 (en) 2009-08-31 2011-03-03 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Oral delivery of a vaccine to the large intestine to induce mucosal immunity
JP5909447B2 (ja) 2009-09-14 2016-04-26 バンヤン・バイオマーカーズ・インコーポレーテッド ニューロン損傷診断のためのマイクロｒｎａ、自己抗体およびタンパク質マーカー
WO2011042564A1 (en) 2009-10-09 2011-04-14 Universite De Strasbourg Labelled silica-based nanomaterial with enhanced properties and uses thereof
CA2777682C (en) 2009-10-13 2015-02-24 The Regents Of The University Of Michigan Dendrimer compositions and methods of synthesis
CN104043126A (zh) 2009-10-22 2014-09-17 霍夫曼-拉罗奇有限公司 轴突变性的调节
WO2011059586A2 (en) 2009-10-30 2011-05-19 The Regents Of The University Of Michigan Multifunctional small molecules
US8236570B2 (en) 2009-11-03 2012-08-07 Infoscitex Methods for identifying nucleic acid ligands
US8841429B2 (en) 2009-11-03 2014-09-23 Vivonics, Inc. Nucleic acid ligands against infectious prions
EP2501398A1 (de) 2009-11-06 2012-09-26 INSERM - Institut National de la Santé et de la Recherche Médicale Verfahren und pharmazeutische zusammensetzungen zur behandlung von atherosklerose
US11051744B2 (en) 2009-11-17 2021-07-06 Setpoint Medical Corporation Closed-loop vagus nerve stimulation
US9833621B2 (en) 2011-09-23 2017-12-05 Setpoint Medical Corporation Modulation of sirtuins by vagus nerve stimulation
AU2010321885B2 (en) 2009-11-20 2015-12-24 The Regents Of The University Of California Epithelial membrane protein-2 (EMP2) and proliferative vitreoretinopathy (PVR)
US20120251562A1 (en) 2009-11-23 2012-10-04 Philippe Pierre Inhibitors of the PP1/GADD34 Complex for the Treatment of a Condition Requiring an Immunosuppressive Activity
DE102009056945A1 (de) 2009-12-07 2011-06-16 Christian-Albrechts-Universität Zu Kiel DNA-Aptamere, die den löslichen Interleukin-6-Rezeptor spezifisch binden
DE102009056944A1 (de) 2009-12-07 2011-06-09 Christian-Albrechts-Universität Zu Kiel RNA-Aptamere, die den löslichen Interleukin-6-Rezeptor spezifisch binden
EP2517025B1 (de) 2009-12-23 2019-11-27 Bio-Rad Laboratories, Inc. Verfahren zur reduzierung des austauschs von molekülen zwischen tröpfchen
WO2011079309A2 (en) 2009-12-23 2011-06-30 Setpoint Medical Corporation Neural stimulation devices and systems for treatment of chronic inflammation
US20110165037A1 (en) * 2010-01-07 2011-07-07 Ismagilov Rustem F Interfaces that eliminate non-specific adsorption, and introduce specific interactions
LT2523661T (lt) 2010-01-15 2017-08-10 INSERM (Institut National de la SantƩ et de la Recherche MƩdicale) Nkcc inhibitoriai autizmo gydymui
GB2489187B (en) 2010-01-20 2015-02-11 New England Biolabs Inc Compositions, methods and related uses for cleaving modified DNA
US20110201076A1 (en) 2010-01-22 2011-08-18 Colorado School Of Mines Harvesting micro algae
US20130149314A1 (en) 2010-02-09 2013-06-13 Jörn Bullerdiek p19Arf, HMGA2 and MDM2 For Use in the Diagnosis and Treatment of Aberrant Cell Growth
EP2535410A4 (de) 2010-02-12 2014-08-13 Ribomic Inc Aptamer für fgf2 und verwendung davon
WO2011100561A1 (en) 2010-02-12 2011-08-18 Saint Louis University Molecular biosensors capable of signal amplification
US9399797B2 (en) 2010-02-12 2016-07-26 Raindance Technologies, Inc. Digital analyte analysis
US9366632B2 (en) 2010-02-12 2016-06-14 Raindance Technologies, Inc. Digital analyte analysis
US10351905B2 (en) 2010-02-12 2019-07-16 Bio-Rad Laboratories, Inc. Digital analyte analysis
US9556249B2 (en) 2010-02-18 2017-01-31 Genentech, Inc. Neuregulin antagonists and use thereof in treating cancer
US8236574B2 (en) 2010-03-01 2012-08-07 Quanterix Corporation Ultra-sensitive detection of molecules or particles using beads or other capture objects
CN103026232B (zh) 2010-03-01 2015-02-04 匡特里克斯公司 扩大用于检测分子或颗粒的测定法中的动态范围的方法和系统
US9678068B2 (en) 2010-03-01 2017-06-13 Quanterix Corporation Ultra-sensitive detection of molecules using dual detection methods
WO2011109642A1 (en) 2010-03-03 2011-09-09 Somalogic, Inc. Aptamers to 4-1bb and their use in treating diseases and disorders
WO2011113118A1 (en) 2010-03-19 2011-09-22 Katholieke Universiteit Leuven Drug tolerance/persistence of fungal biofilms
PL2551346T3 (pl) 2010-03-24 2016-07-29 Ribomic Inc Aptamer dla NGF i jego zastosowanie
WO2011123844A2 (en) 2010-04-01 2011-10-06 Banyan Biomarkers, Inc. Markers and assays for detection of neurotoxicity
CA2795390C (en) 2010-04-08 2020-11-03 Inserm (Institut National De La Sante Et De La Recherche Medicale) Inhibiting peptides derived from trem-like transcript 1 (tlt-1) and uses thereof
CN104069512A (zh) 2010-04-12 2014-10-01 私募蛋白质体公司 针对β-NGF的适体及其在治疗β-NGF介导的疾病和失调中的用途
US9995679B2 (en) 2010-05-25 2018-06-12 Carnegie Mellon University Targeted probes of cellular physiology
EP2589657A4 (de) * 2010-07-01 2014-04-23 Nat Inst Of Advanced Ind Scien Verfahren zum nachweis von zielmolekülen
EP2589653A1 (de) * 2010-07-02 2013-05-08 NEC Soft, Ltd. Vorhersagevorrichtung, vorhersageverfahren, programm und aufzeichnungsmedium
BR112013001062A2 (pt) 2010-07-15 2016-05-24 Synovex Corp anticorpos humanizados que visam o domínio ec1 de caderina-11 e composições e métodos relacionados
WO2012016188A2 (en) 2010-07-30 2012-02-02 Alnylam Pharmaceuticals, Inc. Methods and compositions for delivery of active agents
EP2603587B1 (de) 2010-08-09 2015-10-07 INSERM (Institut National de la Santé et de la Recherche Médicale) Pharmazeutische zusammensetzungen zur behandlung und prävention von hiv-1-infektionen
EP2603607B1 (de) 2010-08-11 2016-04-06 Celula, Inc. Dns genotypisierung
WO2012021913A1 (en) 2010-08-18 2012-02-23 University Of Graz Methods for increasing resistance of plants to drought, salt and pathogens
WO2012022496A2 (en) 2010-08-19 2012-02-23 Per Sonne Holm Method for killing tumor stem cells
US20130183718A1 (en) 2010-09-21 2013-07-18 RibpxX GmbH Method for Synthesizing RNA using DNA Template
AU2011312491B2 (en) 2010-09-27 2015-06-04 Somalogic, Inc. Mesothelioma biomarkers and uses thereof
WO2012045012A2 (en) 2010-09-30 2012-04-05 Raindance Technologies, Inc. Sandwich assays in droplets
EP2628013B1 (de) 2010-10-14 2019-06-12 The Johns Hopkins University Biomarker für gehirnverletzungen
WO2012051571A2 (en) 2010-10-14 2012-04-19 Regado Biosciences, Inc. Nucleic acid modulators of clec-2
CA3060724A1 (en) 2010-11-05 2012-05-10 Genalyte, Inc. Optical analyte detection systems and methods of use
US9072766B2 (en) 2010-11-18 2015-07-07 Beth Israel Deaconess Medical Center, Inc. Methods of treating obesity by inhibiting nicotinamide N-methyl transferase (NNMT)
WO2012090150A2 (en) 2010-12-27 2012-07-05 Compugen Ltd New cell-penetrating peptides and uses thereof
EP2663640B1 (de) 2011-01-10 2020-11-04 APTARION biotech AG Nukleinsäuremolekül mit bindungsaffinität für ein zielmolekül und verfahren zu seiner erzeugung
WO2012100078A1 (en) 2011-01-19 2012-07-26 Ohmx Corporation Enzyme triggered redox altering chemical elimination (e-trace) immmunoassay
EP2666008B1 (de) 2011-01-21 2021-08-11 Labrador Diagnostics LLC Systeme und verfahren zur maximierung der verwendung einer probe
WO2012107728A2 (en) 2011-02-09 2012-08-16 Cancer Research Technology Limited Frmd4a antagonists and their uses
EP3412778A1 (de) 2011-02-11 2018-12-12 Raindance Technologies, Inc. Verfahren zur bildung gemischter tröpfchen
WO2012112804A1 (en) 2011-02-18 2012-08-23 Raindance Technoligies, Inc. Compositions and methods for molecular labeling
WO2012138694A2 (en) 2011-04-07 2012-10-11 Emory University Compositions comprising saccharide binding moieties and methods for targeted therapy
JP6347743B2 (ja) 2011-05-05 2018-06-27 マティナス バイオファーマ ナノテクノロジーズ，インコーポレーテッド コクリエート組成物およびその製造および使用方法
WO2012152711A1 (en) 2011-05-06 2012-11-15 Institut National De La Sante Et De La Recherche Medicale (Inserm) Methods for identifying aptamers
WO2012154865A2 (en) 2011-05-09 2012-11-15 Setpoint Medical Corporation Single-pulse activation of the cholinergic anti-inflammatory pathway to treat chronic inflammation
US20140141458A1 (en) 2011-05-12 2014-05-22 The Johns Hopkins University Assay reagents for a neurogranin diagnostic kit
WO2012156476A2 (en) 2011-05-16 2012-11-22 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for screening substances capable of modulating the replication of an influenza virus
AR086543A1 (es) 2011-05-25 2014-01-08 Bg Medicine Inc Inhibidores de galectina-3 y metodos de uso de los mismos, composicion farmaceutica
WO2012167142A2 (en) 2011-06-02 2012-12-06 Raindance Technolgies, Inc. Enzyme quantification
US8841071B2 (en) 2011-06-02 2014-09-23 Raindance Technologies, Inc. Sample multiplexing
GB201110371D0 (en) 2011-06-17 2011-08-03 Proteome Sciences R & D Gmbh & Co Kg Materials and methods for determining sensitivity potential of compounds
US8658430B2 (en) 2011-07-20 2014-02-25 Raindance Technologies, Inc. Manipulating droplet size
EP2734531A1 (de) 2011-07-22 2014-05-28 Université de Strasbourg Phospholipidwaschmittelkonjugate und ihre verwendungen
CN103842030B (zh) 2011-08-01 2018-07-31 霍夫曼-拉罗奇有限公司 使用pd-1轴结合拮抗剂和mek抑制剂治疗癌症的方法
CN103732748A (zh) 2011-08-12 2014-04-16 塔古西库斯生物株式会社 核酸适配体的制造方法
GB201114662D0 (en) 2011-08-24 2011-10-12 Altermune Technologies Llc Chemically programmable immunity
EP2753697A1 (de) 2011-09-05 2014-07-16 ETH Zürich Biosynthetischer gencluster zur herstellung von peptid- bzw. protein-analoga
WO2013034687A1 (en) 2011-09-09 2013-03-14 Universität Bern Verwaltungsdirektion Avibacterium paragallinarum rtx toxin
US8435738B2 (en) 2011-09-25 2013-05-07 Theranos, Inc. Systems and methods for multi-analysis
US8475739B2 (en) 2011-09-25 2013-07-02 Theranos, Inc. Systems and methods for fluid handling
US9664702B2 (en) 2011-09-25 2017-05-30 Theranos, Inc. Fluid handling apparatus and configurations
US9268915B2 (en) 2011-09-25 2016-02-23 Theranos, Inc. Systems and methods for diagnosis or treatment
US9632102B2 (en) 2011-09-25 2017-04-25 Theranos, Inc. Systems and methods for multi-purpose analysis
US9619627B2 (en) 2011-09-25 2017-04-11 Theranos, Inc. Systems and methods for collecting and transmitting assay results
US20140170735A1 (en) 2011-09-25 2014-06-19 Elizabeth A. Holmes Systems and methods for multi-analysis
US8840838B2 (en) 2011-09-25 2014-09-23 Theranos, Inc. Centrifuge configurations
WO2013040577A1 (en) 2011-09-16 2013-03-21 The Research Foundation Of State University Of New York Aptamers resistant to nucleocapsid degradation
BR112014006419A2 (pt) 2011-09-19 2018-08-07 Genentech Inc métodos para tratar um paciente com câncer, kit e artigo
US9810704B2 (en) 2013-02-18 2017-11-07 Theranos, Inc. Systems and methods for multi-analysis
US10012664B2 (en) 2011-09-25 2018-07-03 Theranos Ip Company, Llc Systems and methods for fluid and component handling
US9250229B2 (en) 2011-09-25 2016-02-02 Theranos, Inc. Systems and methods for multi-analysis
HUE039439T2 (hu) 2011-09-28 2018-12-28 Ribomic Inc NGF aptamer és alkalmazása
BR112014007501A2 (pt) 2011-09-30 2017-04-04 Mallinckrodt Llc conjunto remoto de nanopartículas direcionadas usando ligantes de oligonucleotídeos complementares
EP2764118A1 (de) 2011-10-05 2014-08-13 University of Bremen Wnt4 und med12 zur verwendung bei der diagnose und behandlung von tumorerkrankungen
CA2851632A1 (en) 2011-10-17 2013-04-25 Ohmx Corporation Single, direct detection of hemoglobin a1c percentage using enzyme triggered redox altering chemical elimination (e-trace) immunoassay
CA2852709A1 (en) 2011-10-28 2013-05-02 Patrys Limited Pat-lm1 epitopes and methods for using same
WO2013065016A1 (en) 2011-11-02 2013-05-10 University Of Cape Town A method of detecting and/or quantifying an analyte in a biological sample
WO2013067349A1 (en) 2011-11-04 2013-05-10 Ohmx Corporation Novel chemistry used in biosensors
SG11201402402SA (en) 2011-11-18 2014-09-26 Tagcyx Biotechnologies Nucleic acid fragment binding to target protein
FR2983212A1 (fr) 2011-11-28 2013-05-31 Lfb Biotechnologies Aptameres anti-fh, procede pour leur obtention et utilisations
EP4349343A2 (de) 2011-11-30 2024-04-10 Jörn Bullerdiek Expression von mirnas in plazentagewebe
WO2013085718A1 (en) 2011-12-08 2013-06-13 The Regents Of The University Of Michigan Multifunctional small molecules
JP6276706B2 (ja) 2012-01-09 2018-02-07 オームクス コーポレイション Ｅ−ｔｒａｃｅアッセイシグナル増幅の酵素カスケード方法
EP2809769B1 (de) 2012-01-31 2018-09-05 The University of Toledo Verfahren und vorrichtungen zur erkennung und messung von analyten
US9737480B2 (en) 2012-02-06 2017-08-22 President And Fellows Of Harvard College ARRDC1-mediated microvesicles (ARMMs) and uses thereof
FR2987627B1 (fr) 2012-03-05 2016-03-18 Splicos Utilisation de rbm39 comme biomarqueur
US20130261010A1 (en) 2012-03-12 2013-10-03 The Board Of Trustees Of The University Of Illinois Optical analyte detection systems with magnetic enhancement and methods of use
WO2013142255A2 (en) 2012-03-22 2013-09-26 University Of Miami Multi-specific binding agents
US9572983B2 (en) 2012-03-26 2017-02-21 Setpoint Medical Corporation Devices and methods for modulation of bone erosion
WO2013152252A1 (en) 2012-04-06 2013-10-10 OSI Pharmaceuticals, LLC Combination anti-cancer therapy
JP2015521041A (ja) 2012-05-16 2015-07-27 サイレンス・セラピューティクス・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング Ｐｋｎ３阻害剤投与のためのバイオマーカーとしてのｖｅｇｆｒ１の使用
AU2013266243A1 (en) 2012-05-24 2014-12-18 Beth Israel Deaconess Medical Center, Inc. Targeting the glutamine to pyruvate pathway for treatment of oncogenic Kras-associated cancer
JP6298456B2 (ja) 2012-06-07 2018-03-20 ソマロジック・インコーポレーテッド アプタマーに基づく多重化アッセイ
US9211185B2 (en) 2012-06-13 2015-12-15 Elwha Llc Breast implant with analyte sensors and internal power source
US9144488B2 (en) 2012-06-13 2015-09-29 Elwha Llc Breast implant with analyte sensors responsive to external power source
US8808373B2 (en) 2012-06-13 2014-08-19 Elwha Llc Breast implant with regionalized analyte sensors responsive to external power source
US9144489B2 (en) 2012-06-13 2015-09-29 Elwha Llc Breast implant with covering, analyte sensors and internal power source
US8795359B2 (en) 2012-06-13 2014-08-05 Elwha Llc Breast implant with regionalized analyte sensors and internal power source
US8790400B2 (en) 2012-06-13 2014-07-29 Elwha Llc Breast implant with covering and analyte sensors responsive to external power source
WO2014003830A1 (en) 2012-06-25 2014-01-03 Emory University Particle-nucleic acid conjugates and therapeutic uses related thereto
KR102450907B1 (ko) 2012-07-13 2022-10-04 웨이브 라이프 사이언시스 리미티드 키랄 제어
US20150285802A1 (en) 2012-07-18 2015-10-08 Dana-Farber Cancer Institute, Inc. Methods for treating, preventing and predicting risk of developing breast cancer
CN112587658A (zh) 2012-07-18 2021-04-02 博笛生物科技有限公司 癌症的靶向免疫治疗
US9416390B2 (en) 2012-07-27 2016-08-16 Ohmx Corporation Electric measurement of monolayers following pro-cleave detection of presence and activity of enzymes and other target analytes
US9404883B2 (en) 2012-07-27 2016-08-02 Ohmx Corporation Electronic measurements of monolayers following homogeneous reactions of their components
CN104919054A (zh) 2012-07-31 2015-09-16 胡安·卡洛斯·海梅 获得并检测待鉴定对象之标志物的方法、相关标志物、认证方法以及验证方法
CN104781417B (zh) * 2012-08-02 2017-12-12 迪肯大学 用于检测癌症干细胞的cd133适配子
CA2880833A1 (en) 2012-08-03 2014-02-06 Aptamir Therapeutics, Inc. Cell-specific delivery of mirna modulators for the treatment of obesity and related disorders
AU2013204200B2 (en) 2012-10-11 2016-10-20 Brandeis University Treatment of amyotrophic lateral sclerosis
DE102012020496A1 (de) 2012-10-18 2014-04-24 Charité - Universitätsmedizin Berlin Biomarker zur Diagnostik und Behandlung von Neurofibromatose Typ 1
US10942184B2 (en) 2012-10-23 2021-03-09 Caris Science, Inc. Aptamers and uses thereof
US9958448B2 (en) 2012-10-23 2018-05-01 Caris Life Sciences Switzerland Holdings Gmbh Aptamers and uses thereof
US9957553B2 (en) 2012-10-24 2018-05-01 Genmark Diagnostics, Inc. Integrated multiplex target analysis
KR102356017B1 (ko) 2012-12-13 2022-01-27 이뮤노메딕스, 인코오포레이티드 개선된 효능 및 감소된 독성을 위한 항체 및 sn-38의 면역컨쥬게이트의 투약
US9939443B2 (en) 2012-12-19 2018-04-10 Caris Life Sciences Switzerland Holdings Gmbh Compositions and methods for aptamer screening
FR3000105B1 (fr) * 2012-12-24 2015-05-15 Lvmh Rech Aptameres inhibiteurs de l'activite enzymatique de la tyrosinase
US9731032B2 (en) 2013-02-04 2017-08-15 The Cleveland Clinic Foundation Aptamers for tumor initiating cells
EP2958038A1 (de) 2013-02-15 2015-12-23 NEC Solution Innovators, Ltd. Auswahlvorrichtung für kandidatensequenzinformationen zur ähnlichkeitsbestimmung, auswahlverfahren und verwendung für solch eine vorrichtung und verfahren
EP2774930A1 (de) 2013-03-07 2014-09-10 Aptenia S.R.L. Metallocenverbindungen und markierte Moleküle damit für In-vivo-Bildgebung
EP4066841A1 (de) 2013-03-14 2022-10-05 University of Maryland, Baltimore Mittel zur androgenrezeptor-abwärtsregelung und verwendungen davon
US9052314B2 (en) 2013-03-14 2015-06-09 Silver Lake Research Corporation Biomarkers for detecting the presence of bacteria
DK2970915T3 (da) 2013-03-15 2019-11-11 Maxcyte Inc Fremgangsmåder og sammensætninger til generering af stabile transficerede celler
US9983206B2 (en) 2013-03-15 2018-05-29 The Board Of Trustees Of The University Of Illinois Methods and compositions for enhancing immunoassays
CN108957006B (zh) 2013-03-15 2021-07-27 私募蛋白质体公司 非酒精性脂肪肝疾病(nafld)和非酒精性脂肪性肝炎(nash)生物标记及其用途
KR101807590B1 (ko) 2013-03-22 2017-12-11 고쿠리츠다이가쿠호징 도쿄다이가쿠 Il-17에 대한 앱타머 및 그 사용
AU2014241170A1 (en) 2013-03-27 2015-09-24 Theranos Ip Company, Llc Methods, devices, and systems for sample analysis
JP6440692B2 (ja) 2013-05-23 2018-12-19 アイフィノタイプ エルエルシー 個人、製品提供者および／またはサービス提供者を支援する方法およびシステム
GB201310203D0 (en) 2013-06-07 2013-07-24 Electrophoretics Ltd Materials and methods relating to Alzheimer's disease
WO2014200767A1 (en) 2013-06-12 2014-12-18 The General Hospital Corporation Methods, kits, and systems for multiplexed detection of target molecules and uses thereof
CA2915149C (en) 2013-06-12 2019-02-05 The Governing Council Of The University Of Toronto Catalytic nucleic acid and gold nanoparticles for detection of biomolecules
EP3008094B1 (de) 2013-06-14 2018-12-26 Pacific Biosciences Of California, Inc. Bis-biotinylierungsetiketten
CN105555365A (zh) 2013-06-25 2016-05-04 堪培拉大学 用于调控癌症干细胞的方法和组合物
EP3014264A4 (de) 2013-06-25 2016-11-16 Two Pore Guys Inc Quantifizierung multiplexierter biomarker durch nanoporenanalyse von biomarker-polymer-komplexen
CN110193009A (zh) 2013-07-12 2019-09-03 伊维希比奥公司 用于治疗或预防眼科病的方法
ES2819209T3 (es) 2013-07-16 2021-04-15 Hoffmann La Roche Procedimientos de tratamiento del cáncer usando antagonistas de unión al eje de PD-1 e inhibidores de TIGIT
WO2015009907A1 (en) 2013-07-17 2015-01-22 The Johns Hopkins University A multi-protein biomarker assay for brain injury detection and outcome
EP3033088A4 (de) 2013-08-12 2017-03-08 Tokai Pharmaceuticals, Inc. Biomarker zur behandlung neoplastischer störungen mit androgen-anzielenden therapien
EP2837939A1 (de) 2013-08-13 2015-02-18 Technische Universität München Verfahren zum Nachweis von H.pylori-Infektionen
GB201314485D0 (en) 2013-08-13 2013-09-25 Electrophoretics Ltd Materials and methods relating to pancreatic cancer
BR102013021701A2 (pt) 2013-08-26 2015-07-28 Univ São Paulo Usp Polinucleotídeos quimicamente modificados e processo de produção de polinucleotídeos quimicamente modificados
BR112016004153A2 (pt) 2013-08-28 2019-09-17 Caris Life Sciences Switzerland Holdings Gmbh "método para caracterizar uma doença ou distúrbio, kit, composição, método para gerar uma biblioteca de entrada, oligonucleotídeo, pluralidade de oligonucleotídeos e método para identificar um aptâmero
GB201315743D0 (en) 2013-09-04 2013-10-16 Maersk Olie & Gas Provision and uses of wettability modifiers
US11545241B1 (en) 2013-09-07 2023-01-03 Labrador Diagnostics Llc Systems and methods for analyte testing and data management
CA3221709A1 (en) 2013-09-09 2015-03-12 Somalogic Operating Co., Inc. Pdgf and vegf aptamers having improved stability and their use in treating pdgf and vegf mediated diseases and disorders
WO2015036618A1 (en) 2013-09-16 2015-03-19 INSERM (Institut National de la Santé et de la Recherche Médicale) Method and pharmaceutical composition for use in the treatment of epilepsy
ES2851724T3 (es) 2013-09-18 2021-09-08 Epiaxis Therapeutics Pty Ltd Modulación de células madre
US11901041B2 (en) 2013-10-04 2024-02-13 Bio-Rad Laboratories, Inc. Digital analysis of nucleic acid modification
RU2020111934A (ru) 2013-10-08 2020-04-29 Промедиор, Инк. Способы лечения фиброзного рака
WO2015062743A1 (en) 2013-11-04 2015-05-07 Noxxon Pharma Ag Means and methods for the treatment of nephropathy
EP3068882A2 (de) 2013-11-13 2016-09-21 INSERM (Institut National de la Santé et de la Recherche Médicale) Kits von teilen mit nukleinsäuren mit fähigkeit zur bildung eines kissing-komplexes und verwendungen davon
GB201320061D0 (en) 2013-11-13 2013-12-25 Electrophoretics Ltd Materials nad methods for diagnosis and prognosis of liver cancer
AR093574A1 (es) 2013-11-21 2015-06-10 Consejo Nac De Investig Cientificas Y Tecn (Conicet) Aptameros contra la proteina basica de mielina como agentes neuroprotectores
BR112016010165A2 (pt) 2013-11-21 2017-12-05 Somalogic Inc composições de nucleotídeos modificados de citidina-5-carboxamida e métodos relacionados às mesmas
DE102013112915A1 (de) 2013-11-22 2015-05-28 Universitätsklinikum Hamburg-Eppendorf (UKE) DNA-Aptamere, die E- und P-Selektine spezifisch binden
KR20160095003A (ko) 2013-12-05 2016-08-10 사일런스 테라퓨틱스 게엠베하 폐 특이적 전달을 위한 수단
US9944977B2 (en) 2013-12-12 2018-04-17 Raindance Technologies, Inc. Distinguishing rare variations in a nucleic acid sequence from a sample
CN105899535A (zh) 2013-12-17 2016-08-24 豪夫迈·罗氏有限公司 用pd-1轴结合拮抗剂和抗cd20抗体治疗癌症的方法
EP3090063B1 (de) 2013-12-31 2019-11-06 Bio-Rad Laboratories, Inc. Verfahren zur detektion von latentem retrovirus
CA2936377A1 (en) 2014-01-10 2015-07-16 Shanghai Birdie Biotech, Inc. Compounds and compositions for treating egfr expressing tumors
EP3102708B1 (de) 2014-02-05 2020-11-18 Deakin University Aptamerkonstrukt
WO2015120382A1 (en) 2014-02-07 2015-08-13 The Johns Hopkins University Predicting response to epigenetic drug therapy
EP3108045B1 (de) 2014-02-18 2018-10-31 Somalogic, Inc. Vorrichtungen und verfahren zur detektion von mikroorganismen
US10307472B2 (en) 2014-03-12 2019-06-04 Curevac Ag Combination of vaccination and OX40 agonists
US20170166894A1 (en) 2014-03-17 2017-06-15 Glaxosmithkline Intellectual Property Development Limited Aptamers for topical delivery
EP3119913B1 (de) 2014-03-21 2021-01-06 The Brigham and Women's Hospital, Inc. Verfahren und zusammensetzungen zur behandlung von immunbedingten erkrankungen oder störungen und/oder therapieüberwachung
MA39776A (fr) 2014-03-24 2017-02-01 Hoffmann La Roche Traitement du cancer avec des antagonistes de c-met et corrélation de ces derniers avec l'expression de hgf
JP6634554B2 (ja) 2014-03-24 2020-01-22 株式会社リボミック Ｆｇｆ２に対するアプタマー及びその使用
US10350264B2 (en) 2014-03-27 2019-07-16 Dana-Farber Cancer Institute, Inc. Compositions and methods for modulating NCOA4-mediated autophagic targeting of ferritin
US20150361163A1 (en) 2014-04-18 2015-12-17 Acceleron Pharma, Inc. Methods for increasing red blood cell levels and treating sickle-cell disease
WO2015164617A1 (en) 2014-04-24 2015-10-29 Somalogic, Inc. Tuberculosis biomarkers in urine and uses thereof
WO2015164616A1 (en) 2014-04-24 2015-10-29 Somalogic, Inc. Biomarkers for detection of tuberculosis
CN106662583A (zh) 2014-04-29 2017-05-10 Ohmx公司 使用峰曲线的生物电子结合测定
EP3154566B1 (de) 2014-06-13 2022-08-03 Acceleron Pharma Inc. Actrii antagonist zur behandlung oder prävention eines hautulzers in einem patienten mit anämie
TWI727427B (zh) 2014-07-09 2021-05-11 英屬開曼群島商博笛生物科技有限公司 用於治療腫瘤的抗pd-1組合
CN105440135A (zh) 2014-09-01 2016-03-30 博笛生物科技有限公司 用于治疗肿瘤的抗-pd-l1结合物
CN105233291A (zh) 2014-07-09 2016-01-13 博笛生物科技有限公司 用于治疗癌症的联合治疗组合物和联合治疗方法
SG11201700074YA (en) 2014-07-15 2017-02-27 Genentech Inc Compositions for treating cancer using pd-1 axis binding antagonists and mek inhibitors
US20160041118A1 (en) 2014-08-11 2016-02-11 Ohmx Corporation Enzyme triggered redox altering chemical elimination (e-trace) assay with multiplexing capabilities
EP3182917A1 (de) 2014-08-20 2017-06-28 Memorial Sloan Kettering Cancer Center Raman-ausgelöste ablation-/resektionssysteme und verfahren
RU2708237C2 (ru) 2014-08-22 2019-12-05 Общество с ограниченной ответственностью "НооГен" Модифицированные олигонуклеотиды и способ их получения
AU2015309686B2 (en) 2014-08-25 2020-05-14 Epiaxis Therapeutics Pty Ltd Compositions for modulating cancer stem cells and uses therefor
EP3185910A4 (de) 2014-08-29 2018-01-10 Children's Medical Center Corporation Verfahren und zusammensetzungen zur krebsbehandlung
WO2016040830A1 (en) 2014-09-12 2016-03-17 Mediomics, Llc Molecular biosensors with a modular design
US10222386B2 (en) 2014-09-19 2019-03-05 The Johns Hopkins University Biomarkers of congnitive dysfunction
AU2014407088B2 (en) 2014-09-26 2021-09-23 Somalogic Operating Co., Inc. Cardiovascular risk event prediction and uses thereof
EP3000483A1 (de) 2014-09-29 2016-03-30 Charité - Universitätsmedizin Berlin Mittel und Verfahren zur Diagnose und Behandlung von neurodegenerativen Erkrankungen
DE102014114834A1 (de) 2014-10-13 2016-04-14 Centrum Für Angewandte Nanotechnologie (Can) Gmbh Nanopartikel enthaltende Polymermizellen in nicht-wässriger Lösung, Methoden zu ihrer Herstellung und ihrer Anwendung
WO2016061460A1 (en) 2014-10-17 2016-04-21 Carnegie Mellon University Enhanced biomolecule detection assays based on tyramide signal amplification and gammapna probes
US11311725B2 (en) 2014-10-24 2022-04-26 Setpoint Medical Corporation Systems and methods for stimulating and/or monitoring loci in the brain to treat inflammation and to enhance vagus nerve stimulation
US9816080B2 (en) 2014-10-31 2017-11-14 President And Fellows Of Harvard College Delivery of CAS9 via ARRDC1-mediated microvesicles (ARMMs)
CN107073126A (zh) 2014-11-06 2017-08-18 豪夫迈·罗氏有限公司 包含ox40结合激动剂和tigit抑制剂的组合疗法
FR3028527A1 (fr) 2014-11-13 2016-05-20 Pivert Identification de facteurs de transcription de yarrowia lipolytica
WO2016075314A1 (fr) 2014-11-13 2016-05-19 Institut National De La Recherche Agronomique Identification de facteurs de transcription de yarrowia lipolytica affectant la production de proteines
CN107429075B (zh) 2014-11-17 2022-11-01 卡内基梅隆大学 可激活的双组份光敏剂
TWI695068B (zh) 2014-11-24 2020-06-01 美商身體邏輯股份有限公司 用於結合生長分化因子１１的核酸化合物
MA41119A (fr) 2014-12-03 2017-10-10 Acceleron Pharma Inc Méthodes de traitement de syndromes myélodysplasiques et d'anémie sidéroblastique
CN107427573B (zh) 2014-12-24 2022-12-27 耐克西缪恩有限公司 用于免疫疗法的纳米颗粒组合物和方法
WO2016123058A1 (en) 2015-01-27 2016-08-04 Somalogic, Inc. Biomarkers for detection of tuberculosis risk
EP3892726A1 (de) 2015-02-02 2021-10-13 Meiragtx UK II Limited Regulierung der gen-expression durch aptamer-vermittelte modulation von alternativem spleissen
US11406833B2 (en) 2015-02-03 2022-08-09 Setpoint Medical Corporation Apparatus and method for reminding, prompting, or alerting a patient with an implanted stimulator
US10370669B2 (en) 2015-02-09 2019-08-06 Somalogic, Inc. Nucleic acid compounds for binding growth differentiation factor 8
US11041865B2 (en) 2015-02-20 2021-06-22 The Johns Hopkins University Biomarkers of myocardial injury
WO2016135300A1 (en) 2015-02-26 2016-09-01 Qiagen Gmbh Efficiency improving methods for gene library generation
CN107614703A (zh) 2015-02-27 2018-01-19 香港大学 Dna展示及其方法
WO2016138231A2 (en) 2015-02-27 2016-09-01 Sauder Timothy Lee Molcular barcoded bi-stable switch
US10620185B2 (en) 2015-02-27 2020-04-14 Aptascan, Inc. Molecular barcoded bi-stable switch
WO2016145128A1 (en) 2015-03-09 2016-09-15 Caris Science, Inc. Oligonucleotide probes and uses thereof
WO2016145362A2 (en) 2015-03-12 2016-09-15 The Regents Of The University Of Michigan Inhibitors of dek protein and related methods
US10016341B2 (en) 2015-03-30 2018-07-10 Elwha Llc Systems and devices for controlling delivery of breast milk supplementation
US9925122B2 (en) 2015-03-30 2018-03-27 Elwha Llc Systems and methods for controlling delivery of breast milk supplementation
US9968523B2 (en) 2015-03-30 2018-05-15 Elwha Llc Systems and devices for controlling delivery of breast milk supplementation
US10290372B2 (en) 2015-03-30 2019-05-14 Elwha Llc Systems and devices for controlling delivery of breast milk supplementation
KR20170132234A (ko) 2015-03-30 2017-12-01 닛산 가가쿠 고교 가부시키 가이샤 혈관 내피 증식 인자 수용체에 결합하는 핵산 앱타머
EP3278108B1 (de) 2015-04-03 2021-03-17 Abbott Laboratories Vorrichtungen und verfahren zur probenanalyse
CA2981512A1 (en) 2015-04-03 2016-10-06 Abbott Laboratories Devices and methods for sample analysis
MA41919A (fr) 2015-04-06 2018-02-13 Acceleron Pharma Inc Hétéromultimères alk4:actriib et leurs utilisations
WO2016164089A2 (en) 2015-04-06 2016-10-13 Acceleron Pharma Inc. Tgf-beta superfamily type i and type ii receptor heteromultimers and uses thereof
CN107980059B (zh) 2015-04-13 2022-11-11 美克斯细胞有限公司 用于修饰基因组dna的方法和组合物
EP3295176A1 (de) 2015-05-08 2018-03-21 Somalogic, Inc. Biomarker zur detektion des tuberkuloserisikos
CA2985818A1 (en) 2015-05-31 2016-12-08 Curegenix Corporation Combination compositions comprising an antagonist of porcupine and a pd-l/pd-1 axis antagonist for immunotherapy
WO2016191811A1 (en) 2015-06-03 2016-12-08 The University Of Queensland Mobilizing agents and uses therefor
US20180155787A1 (en) 2015-06-05 2018-06-07 Regulus Therapeutics Inc. Non-alcoholic fatty liver disease biomarkers
CA2983597A1 (en) 2015-06-25 2016-12-29 Immunomedics, Inc. Combining anti-hla-dr or anti-trop-2 antibodies with microtubule inhibitors, parp inhibitors, bruton kinase inhibitors or phosphoinositide 3-kinase inhibitors significantly improves therapeutic outcome in cancer
US10590425B2 (en) 2015-06-29 2020-03-17 Caris Science, Inc. Therapeutic oligonucleotides
WO2017004463A1 (en) 2015-07-01 2017-01-05 Abbott Laboratories Devices and methods for sample analysis
EP3328427A4 (de) 2015-07-27 2018-12-12 The General Hospital Corporation Antikörperderivate mit bedingt aktivierter effektorfunktion
US10941176B2 (en) 2015-07-28 2021-03-09 Caris Science, Inc. Therapeutic oligonucleotides
EP3331550B1 (de) 2015-08-04 2022-11-02 Acceleron Pharma Inc. Zusammensetzung zur behandlung von myeloproliferativen erkrankungen
AU2016301391B2 (en) 2015-08-04 2022-07-28 Duke University Genetically encoded intrinsically disordered stealth polymers for delivery and methods of using same
WO2017176265A1 (en) 2016-04-06 2017-10-12 Mayo Foundation For Medical Education And Research Carrier-binding agent compositions and methods of making and using the same
US10407484B2 (en) 2015-09-02 2019-09-10 The Regents Of The University Of Colorado, A Body Corporate Compositions and methods for modulating T-cell mediated immune response
DK3344805T3 (da) 2015-09-04 2022-03-07 Neoventures Biotechnology Inc Fremgangsmåde til udvælgelse af aptamerer til ubundne mål
US10647981B1 (en) 2015-09-08 2020-05-12 Bio-Rad Laboratories, Inc. Nucleic acid library generation methods and compositions
CN107923918A (zh) 2015-09-09 2018-04-17 私募蛋白质体公司 用于开发个性化药物治疗计划和基于蛋白质组谱的靶向药物开发的方法
EP3371311B1 (de) 2015-11-06 2021-07-21 Orionis Biosciences BV Bifunktionale chimäre proteine und verwendungen davon
KR20180081608A (ko) 2015-11-19 2018-07-16 아스클리픽스 테라퓨틱스, 엘엘씨. 항-혈관형성, 항-림프관신생, 및 항-부종성 특성을 가진 펩티드 및 나노입자 제제
EP3380121B1 (de) 2015-11-23 2023-12-20 Acceleron Pharma Inc. Actrii-antagonist zur verwendung in der behandlung von augenerkrankungen
WO2017089593A1 (en) 2015-11-26 2017-06-01 Universite Paris Descartes Inhibitors for treating or preventing a pulmonary arterial hypertension in systemic sclerosis patients and method for diagnosing said disease
WO2017094733A1 (ja) 2015-11-30 2017-06-08 日産化学工業株式会社 分子標的医薬に結合するｄｎａアプタマー及びそれを用いる分子標的医薬の検出方法
GB201522186D0 (en) 2015-12-16 2016-01-27 Singapore Health Services Pte Ltd And Nat University Of Singapore The Treatment of fibrosis
US11752213B2 (en) 2015-12-21 2023-09-12 Duke University Surfaces having reduced non-specific binding and antigenicity
DE102016100039A1 (de) 2016-01-04 2017-07-06 Universitätsklinikum Hamburg-Eppendorf (UKE) α6-Integrin bindendes DNA-Aptamer
US10596367B2 (en) 2016-01-13 2020-03-24 Setpoint Medical Corporation Systems and methods for establishing a nerve block
US11471681B2 (en) 2016-01-20 2022-10-18 Setpoint Medical Corporation Batteryless implantable microstimulators
WO2017127758A1 (en) 2016-01-20 2017-07-27 Setpoint Medical Corporation Implantable microstimulators and inductive charging systems
JP2019506159A (ja) 2016-01-20 2019-03-07 ヴィトリサ セラピューティクス， インコーポレイテッド Ｄ因子を阻害するための組成物および方法
US10695569B2 (en) 2016-01-20 2020-06-30 Setpoint Medical Corporation Control of vagal stimulation
BR112018015034A2 (pt) 2016-01-22 2019-02-12 Purdue Research Foundation sistema de marcação de massa carregada
US10583304B2 (en) 2016-01-25 2020-03-10 Setpoint Medical Corporation Implantable neurostimulator having power control and thermal regulation and methods of use
CA3013551A1 (en) 2016-02-05 2017-08-10 Orionis Biosciences Nv Clec9a binding agents and use thereof
CN116008563A (zh) 2016-02-08 2023-04-25 私募蛋白质体操作有限公司 非酒精性脂肪肝疾病(nafld)和非酒精性脂肪性肝炎(nash)生物标记及其用途
WO2017153402A1 (en) 2016-03-07 2017-09-14 Vib Vzw Cd20 binding single domain antibodies
US10731166B2 (en) 2016-03-18 2020-08-04 Caris Science, Inc. Oligonucleotide probes and uses thereof
US11355328B2 (en) 2016-04-13 2022-06-07 Purdue Research Foundation Systems and methods for isolating a target ion in an ion trap using a dual frequency waveform
CN109121413A (zh) 2016-04-14 2019-01-01 弗莱德哈钦森癌症研究中心 使用靶向核酸纳米载体编程治疗性细胞的组合物和方法
WO2017187426A1 (en) 2016-04-29 2017-11-02 Aptamir Therapeutics, Inc. Inhibition of mir-22 mirna by apt-110
WO2017195137A1 (en) 2016-05-10 2017-11-16 Nicolas Arab Compositions and methods for identifying, quantifying, and/or characterizing an analyte
CA3023881A1 (en) 2016-05-13 2017-11-16 Orionis Biosciences Nv Therapeutic targeting of non-cellular structures
WO2017194783A1 (en) 2016-05-13 2017-11-16 Orionis Biosciences Nv Targeted mutant interferon-beta and uses thereof
WO2017205686A1 (en) 2016-05-25 2017-11-30 Caris Science, Inc. Oligonucleotide probes and uses thereof
US11467156B2 (en) 2016-06-01 2022-10-11 Duke University Nonfouling biosensors
US10829563B2 (en) 2016-06-16 2020-11-10 INSERM (Institute National de la Santé et de la Recherche Médicale) Method of screening a candidate compound for activity as an elastase 2A (ELA2A) inhibitor
EP3263706A1 (de) 2016-06-28 2018-01-03 Centre National De La Recherche Scientifique (Cnrs) Auf snat7 abzielende wirkstoffe zur behandlung von erkrankungen im zusammenhang mit der zellstoffwechselumprogrammierung
JP6940532B2 (ja) 2016-06-30 2021-09-29 バイオイズ カンパニー リミテッド 二本鎖核酸信号プローブおよびこれを用いた標的分子の検出方法
RU2763470C2 (ru) 2016-07-01 2021-12-29 Сомалоджик, Инк. Олигонуклеотиды, содержащие модифицированные нуклеозиды
EP3264092A1 (de) 2016-07-01 2018-01-03 Centogene AG Verwendung von lyso-gb1 als krankheitsassoziiertes ziel
US10722558B2 (en) 2016-07-15 2020-07-28 Acceleron Pharma Inc. Compositions and methods for treating pulmonary hypertension
US11041863B2 (en) 2016-07-21 2021-06-22 Retinal Solutions Llc Frizzled-4 mutation indicator of retinopathy and intrauterine growth restriction
BR112019001615A2 (pt) 2016-07-27 2019-04-30 Acceleron Pharma Inc. métodos e composições para tratar mielofibrose
EP3491135A1 (de) 2016-07-28 2019-06-05 Laboratoire Français du Fractionnement et des Biotechnologies Verfahren zur gewinnung von aptameren
US9927441B1 (en) 2016-07-29 2018-03-27 X Development Llc Combinatorial methods for aptamer based proteomics
KR102491566B1 (ko) 2016-08-03 2023-01-26 메이라지티엑스 유케이 Ii 리미티드 압타머의 고속 대량처리 세포-기반 스크리닝
CN109963937A (zh) 2016-08-22 2019-07-02 日产化学株式会社 使用e-钙粘蛋白结合型核酸适配体的细胞支架材料
KR20190053203A (ko) 2016-09-01 2019-05-17 메이오 파운데이션 포 메디칼 에쥬케이션 앤드 리써치 Ｔ－세포 암을 표적화하는 방법 및 조성물
CA3035378A1 (en) 2016-09-01 2018-03-08 Mayo Foundation For Medical Education And Research Carrier-pd-l1 binding agent compositions for treating cancers
KR102486055B1 (ko) 2016-09-06 2023-01-09 메이오 파운데이션 포 메디칼 에쥬케이션 앤드 리써치 파클리탁셀-알부민-결합제 조성물 및 그의 사용 및 제조 방법
US11730823B2 (en) 2016-10-03 2023-08-22 President And Fellows Of Harvard College Delivery of therapeutic RNAs via ARRDC1-mediated microvesicles
KR20190066040A (ko) 2016-10-04 2019-06-12 아스클리픽스 테라퓨틱스, 인크. Tie2 신호전달을 활성화시키기 위한 화합물 및 방법
CN116650622A (zh) 2016-10-05 2023-08-29 艾科赛扬制药股份有限公司 用于治疗肾脏疾病的组合物和方法
WO2018067872A1 (en) 2016-10-05 2018-04-12 Abbott Laboratories Devices and methods for sample analysis
BR112019006930A2 (pt) 2016-10-05 2019-07-02 Abbott Lab dispositivos e métodos para análise de amostra
US11596596B2 (en) 2016-10-14 2023-03-07 CNS Biosciences, Inc. Treating neuropathic pain in spinal cord injured individuals
EP3530738A4 (de) 2016-10-24 2020-06-03 KIM, Sung-Chun Tnf-bindendes aptamer und therapeutische verwendung davon
WO2018077893A1 (en) 2016-10-24 2018-05-03 Orionis Biosciences Nv Targeted mutant interferon-gamma and uses thereof
EP3315125A1 (de) 2016-10-31 2018-05-02 Silence Therapeutics (London) Ltd Lipidnanopartikelformulierung
EP3536803A4 (de) 2016-11-02 2020-07-15 Biois Co., Ltd. Verfahren zur quantitative clusteranalyse des zielproteins mithilfe von sequenzierung der nächsten generation und verwendung davon
EP3332812A1 (de) 2016-12-07 2018-06-13 Rheinische Friedrich-Wilhelms-Universität Bonn Nukleinsäurebasierte anordnung und verwendung der anordnung in der krebstherapie
WO2018115083A1 (en) 2016-12-21 2018-06-28 INSERM (Institut National de la Santé et de la Recherche Médicale) Method of treatment of gut diseases such as irritable bowel syndrome (ibs)
US11648200B2 (en) 2017-01-12 2023-05-16 Duke University Genetically encoded lipid-polypeptide hybrid biomaterials that exhibit temperature triggered hierarchical self-assembly
WO2018136827A1 (en) 2017-01-20 2018-07-26 Vitrisa Therapeutics, Inc. Stem-loop compositions and methods for inhibiting factor d
JP2020505955A (ja) 2017-02-06 2020-02-27 オリオンズ バイオサイエンス インコーポレイテッド 標的化改変型インターフェロン及びその使用
AU2018216032B2 (en) 2017-02-06 2022-04-07 Orionis Biosciences BV Targeted chimeric proteins and uses thereof
CA3050601A1 (en) 2017-02-07 2018-08-16 Vib Vzm Immune-cell targeted bispecific chimeric proteins and uses thereof
CA3054294A1 (en) 2017-02-21 2018-08-30 Xuecui GUO Regulation of gene expression by aptamer-mediated accessibility of polyadenylation signals
WO2018213320A1 (en) 2017-05-15 2018-11-22 Duke University Recombinant production of hybrid lipid-biopolymer materials that self-assemble and encapsulate agents
WO2019005503A1 (en) 2017-06-29 2019-01-03 Rutgers, The State University Of New Jersey COMPOSITIONS AND METHODS TARGETING G12 SIGNALING FOR BRONCHODILATORY THERAPY
WO2019006374A1 (en) 2017-06-30 2019-01-03 Duke University ORDER AND DISORDER AS A DESIGN PRINCIPLE FOR STIMULI-SENSITIVE BIOPOLYMER NETWORKS
EP3428184A1 (de) 2017-07-09 2019-01-16 Universitätsklinikum Hamburg-Eppendorf Mittel zur behandlung von herz-kreislauf-erkrankung
WO2019028427A1 (en) 2017-08-03 2019-02-07 Asclepix Therapeutics, Llc. METHODS OF IDENTIFYING AND PREPARING PHARMACEUTICAL AGENTS TO ACTIVATE TIE2 RECEPTOR
JP2020529444A (ja) 2017-08-09 2020-10-08 ザ プロクター アンド ギャンブル カンパニーＴｈｅ Ｐｒｏｃｔｅｒ ＆ Ｇａｍｂｌｅ Ｃｏｍｐａｎｙ 口腔ケア用途のためのアプタマー
US11173307B2 (en) 2017-08-14 2021-11-16 Setpoint Medical Corporation Vagus nerve stimulation pre-screening test
US10934549B2 (en) 2017-08-18 2021-03-02 University Of Iowa Research Foundation Nucleic acid aptamers
US20200268837A1 (en) 2017-09-20 2020-08-27 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for modulating autophagy
NL2019739B1 (en) 2017-10-16 2019-04-23 Academisch Ziekenhuis Leiden Means and methods for treating muscle degeneration
CA3081823A1 (en) 2017-11-09 2019-05-16 Ribomic Inc. Aptamer for adamts5 and use for aptamer for adamts5
EP3719130A4 (de) 2017-11-30 2021-11-24 Ribomic Inc. Anti-chymase-aptamer und verwendung davon
WO2019132597A1 (ko) 2017-12-28 2019-07-04 주식회사 뉴클릭스바이오 압타머 탬플릿 및 이를 이용한 압타머 제조 방법
EP3521828A1 (de) 2018-01-31 2019-08-07 Centogene AG Verfahren zur diagnose eines hereditären angioödems
CA3090406A1 (en) 2018-02-05 2019-08-08 Orionis Biosciences, Inc. Fibroblast binding agents and use thereof
ES2965632T3 (es) 2018-03-05 2024-04-16 Klinikum Rechts Der Isar Der Technischen Univ Muenchen Tratamiento de tumores mediante una combinación de un adenovirus oncolítico y un inhibidor de CDK4/6
US10481155B2 (en) 2018-03-09 2019-11-19 Somalogic, Inc. Proteomic assay using quantum sensors
US20210023209A1 (en) 2018-03-16 2021-01-28 INSERM (Institut National de la Santé et de la Recherche Médicale) Antigenic peptides deriving from pcsk2 and uses thereof for the diagnosis and treatment of type 1 diabetes
US20210024603A1 (en) 2018-03-16 2021-01-28 INSERM (Institut National de la Santé et de la Recherche Médicale) Antigenic peptides deriving from urocortin 3 and uses thereof for the diagnosis and treatment of type 1 diabetes
WO2019175380A2 (en) 2018-03-16 2019-09-19 INSERM (Institut National de la Santé et de la Recherche Médicale) Antigenic peptides deriving from secretogranin v and uses thereof for the diagnosis and treatment of type 1 diabetes
WO2019202448A1 (en) 2018-04-16 2019-10-24 University Of Cape Town A three-protein proteomic biomarker for prospective determination of risk for development of active tuberculosis
US11660443B2 (en) 2018-04-20 2023-05-30 The Feinstein Institutes For Medical Research Methods and apparatuses for reducing bleeding via electrical trigeminal nerve stimulation
FR3081169B1 (fr) 2018-05-15 2020-06-19 Messenger Biopharma Substitution de la coiffe des arn messagers par deux sequences d'arn introduites a leur extremite 5'
WO2019236632A1 (en) 2018-06-04 2019-12-12 Avon Products. Inc. Protein biomarkers for identifying and treating aging skin and skin conditions
MX2020014143A (es) 2018-06-29 2021-03-25 Procter & Gamble Aptameros para aplicaciones de cuidado del cabello.
CN112771164A (zh) 2018-06-29 2021-05-07 宝洁公司 用于个人护理应用的适配体
US11649275B2 (en) 2018-08-02 2023-05-16 Duke University Dual agonist fusion proteins
US11260229B2 (en) 2018-09-25 2022-03-01 The Feinstein Institutes For Medical Research Methods and apparatuses for reducing bleeding via coordinated trigeminal and vagal nerve stimulation
AU2019352901A1 (en) 2018-10-02 2021-05-27 WearOptimo Pty Ltd Measurement system
US20210317456A1 (en) 2018-10-15 2021-10-14 Somalogic, Inc. Nucleic Acid Compounds for Binding Immunoglobulin G
WO2020079248A1 (en) 2018-10-19 2020-04-23 Neoneuro Early detection of precursor of alzheimer's disease
US20210395805A1 (en) 2018-12-04 2021-12-23 Roche Sequencing Solutions, Inc. Spatially oriented quantum barcoding of cellular targets
WO2020115223A1 (en) 2018-12-05 2020-06-11 Katholieke Universiteit Leuven S100a4 as a marker of treatment with spironolactone, pioglitazone and metformin
CN113164485A (zh) 2018-12-20 2021-07-23 Ksq治疗公司 被取代的吡唑并嘧啶和被取代的嘌呤以及其作为泛素特异性加工蛋白酶1(usp1)抑制剂的用途
US11883401B2 (en) 2019-01-08 2024-01-30 Duke University Compositions for the treatment of pathogenic- and/or chemical-induced lung injury and for the treatment of cancer and methods of using same
WO2020144535A1 (en) 2019-01-08 2020-07-16 Aduro Biotech Holdings, Europe B.V. Methods and compositions for treatment of multiple myeloma
CA3126322A1 (en) 2019-01-21 2020-07-30 Singapore Health Services Pte. Ltd. Treatment of hepatotoxicity
WO2020168059A1 (en) 2019-02-15 2020-08-20 Integral Molecular, Inc. Claudin 6 antibodies and uses thereof
CN113661175A (zh) 2019-02-15 2021-11-16 整体分子公司 包含共同轻链的抗体及其用途
GB201902419D0 (en) 2019-02-22 2019-04-10 Singapore Health Serv Pte Ltd Treatment of kidney injury
CA3134336A1 (en) 2019-03-22 2020-10-01 Somalogic, Inc. Reducing intersample analyte variability in complex biological matrices
WO2020201521A1 (en) 2019-04-04 2020-10-08 Carmentix Pte. Ltd. Biomarker pairs of preterm birth
WO2020201520A1 (en) 2019-04-04 2020-10-08 Carmentix Pte. Ltd. Biomarker pairs of preterm birth
EP3946332A1 (de) 2019-04-05 2022-02-09 Université de Bretagne Occidentale Protease-aktivierte rezeptor-2-inhibitoren zur behandlung einer sensorischen neuropathie, die durch eine marine neurotoxische vergiftung induziert wird
CA3134968A1 (en) 2019-04-16 2020-10-22 Juan Esteban Velasquez Aptamers for odor control applications
GB201906291D0 (en) 2019-05-03 2019-06-19 Singapore Health Serv Pte Ltd Treatment and prevention of metabolic diseases
EP3962936A1 (de) 2019-05-03 2022-03-09 Singapore Health Services Pte. Ltd. Behandlung und vorbeugung von stoffwechselerkrankungen
AU2020278570A1 (en) 2019-05-17 2022-01-06 Somalogic Operating Co., Inc. Controlling intersample analyte variability in complex biological matrices
GB201908544D0 (en) 2019-06-14 2019-07-31 Nat Univ Singapore Treatment and prevention of disease mediated by wwp2
US11198908B2 (en) 2019-06-17 2021-12-14 Biorchestra Co., Ltd. Method for diagnosis of Alzheimer's disease using microRNA
KR102113078B1 (ko) 2019-07-05 2020-05-20 광주과학기술원 압타머의 선별 방법
US11512314B2 (en) 2019-07-12 2022-11-29 Duke University Amphiphilic polynucleotides
WO2021019196A1 (en) 2019-07-31 2021-02-04 University Of Dundee Analyte biosensing
WO2021024020A1 (en) 2019-08-06 2021-02-11 Astellas Pharma Inc. Combination therapy involving antibodies against claudin 18.2 and immune checkpoint inhibitors for treatment of cancer
JP2022543618A (ja) 2019-08-07 2022-10-13 アボット・ラボラトリーズ 多重化のための化学発光化合物
US20220276256A1 (en) 2019-08-07 2022-09-01 Abbott Laboratories Methods for detecting assay interferents and increasing dynamic range
BR112022003666A2 (pt) 2019-09-03 2022-05-24 Somalogic Operating Co Inc Predição de evento de risco cardiovascular e usos da mesma
CN114615996A (zh) 2019-09-05 2022-06-10 慕尼黑工业大学临床教学中心 通过溶瘤腺病毒、cdk4/6抑制剂和其他治疗活性剂的组合治疗肿瘤
WO2021076713A1 (en) 2019-10-16 2021-04-22 Somalogic, Inc. Nucleic acid compounds that bind to retinoic acid-inducible gene i protein
AU2020407285A1 (en) 2019-12-20 2022-08-11 CureVac SE Lipid nanoparticles for delivery of nucleic acids
JP2023509677A (ja) 2020-01-10 2023-03-09 ソマロジック オペレーティング カンパニー インコーポレイテッド 耐糖能異常障害を決定する方法
AU2021220787A1 (en) 2020-02-10 2022-09-01 Somalogic Operating Co., Inc. Nonalcoholic steatohepatitis (NASH) biomarkers and uses thereof
WO2021178923A1 (en) 2020-03-06 2021-09-10 Drinksavvy, Inc. Devices and methods for detecting a target analyte of interest
US20230096625A1 (en) 2020-03-10 2023-03-30 Abbott Laboratories Method for droplet loading into nanowells
GB202004514D0 (en) 2020-03-27 2020-05-13 Inst De Medicina Molecular Joaeo Lobo Antunes Treatment of Immunosuppressive Cancer
GB2594094A (en) 2020-04-17 2021-10-20 Pockit Diagnostics Ltd Method for diagnosing stroke caused by large vessel occlusion
AU2021267083A1 (en) 2020-05-07 2022-12-08 Interoligo Corporation Novel nucleic acid ligand, and method for identifyng same
JP2023526080A (ja) 2020-05-21 2023-06-20 ザ・フェインステイン・インスティチュート・フォー・メディカル・リサーチ 迷走神経刺激のためのシステムおよび方法
TW202214861A (zh) 2020-06-17 2022-04-16 日商力博美科股份有限公司 針對ｉｌ－２１之適體及其用途
GB202009292D0 (en) 2020-06-18 2020-08-05 Singapore Health Serv Pte Ltd Treatment and prevention of disease caused by type IV collagen dysfunction
US11859187B2 (en) 2020-06-25 2024-01-02 The Procter & Gamble Company Aptamers for personal health care applications
EP4178611A1 (de) 2020-07-07 2023-05-17 BioNTech SE Therapeutische rna für hpv-positiven krebs
TW202214869A (zh) 2020-08-18 2022-04-16 西班牙商雷勁那賽克斯公司 用於檢測 sars-cov-2 刺突蛋白之組合物及方法
EP4208204A1 (de) 2020-09-02 2023-07-12 Mayo Foundation for Medical Education and Research Antikörper-nanopartikel-komplexe und verfahren zur herstellung und verwendung davon
WO2022073965A1 (en) 2020-10-07 2022-04-14 Centre National De La Recherche Scientifique (Cnrs) Process for selection of aptamers, riboswitches and desoxyriboswitches
JP2023546563A (ja) 2020-10-20 2023-11-06 ソマロジック オペレーティング カンパニー インコーポレイテッド 心血管イベントリスクの予測
GB202017244D0 (en) 2020-10-30 2020-12-16 Nat Univ Singapore Methods to extend health-span and treat age-related diseases
KR20230098186A (ko) 2020-10-30 2023-07-03 케이에스큐 세러퓨틱스 인코포레이티드 치환된 피라졸로피리미딘의 고체 상태 형태 및 이의 용도
CN112779320B (zh) * 2020-12-04 2023-07-14 深圳市易基因科技有限公司 多区域dna甲基化检测探针设计及其检测方法
KR20230119130A (ko) 2020-12-14 2023-08-16 리제너론 파마슈티칼스 인코포레이티드 인히빈 서브유닛 베타 e(inhbe) 억제제로 대사 장애 및 심혈관 질환을 치료하는 방법
EP4265726A1 (de) 2020-12-18 2023-10-25 TAGCyx Biotechnologies Inc. Desoxyribonukleosid oder desoxyribonukleotid mit neuartiger künstlicher basis zur verwendung für das screening auf ein dna-aptamer sowie nukleinsäure damit
TW202245808A (zh) 2020-12-21 2022-12-01 德商拜恩迪克公司 用於治療癌症之治療性ｒｎａ
WO2022135666A1 (en) 2020-12-21 2022-06-30 BioNTech SE Treatment schedule for cytokine proteins
WO2022135667A1 (en) 2020-12-21 2022-06-30 BioNTech SE Therapeutic rna for treating cancer
WO2022162015A1 (en) 2021-01-26 2022-08-04 Universite Brest Bretagne Occidentale Novel stim1 splicing variants and uses thereof
TW202304506A (zh) 2021-03-25 2023-02-01 日商安斯泰來製藥公司 涉及抗claudin 18.2抗體的組合治療以治療癌症
AU2022258298A1 (en) 2021-04-13 2023-10-05 Somalogic Operating Co., Inc. Modified nucleosides
EP4323524A1 (de) 2021-04-14 2024-02-21 SomaLogic Operating Co., Inc. Coronavirusproteine bindende nukleinsäureverbindungen
WO2022232308A1 (en) 2021-04-27 2022-11-03 Singular Genomics Systems, Inc. High density sequencing and multiplexed priming
WO2022266031A2 (en) 2021-06-15 2022-12-22 Somalogic Operating Co., Inc. Renal insufficiency prediction and uses thereof
WO2023278502A1 (en) 2021-06-30 2023-01-05 Somalogic Operating Co., Inc. Renal health determination and uses thereof
AU2022312698A1 (en) 2021-07-13 2024-01-25 BioNTech SE Multispecific binding agents against cd40 and cd137 in combination therapy for cancer
WO2023006765A1 (en) 2021-07-26 2023-02-02 Boehringer Ingelheim International Gmbh Treatment and prevention of alcoholic liver disease
WO2023014193A1 (ko) 2021-08-06 2023-02-09 인터올리고 주식회사 비천연 핵산 리간드를 유효성분으로 포함하는 삼중음성 유방암의 치료를 위한 약학적 조성물
WO2023031394A1 (en) 2021-09-03 2023-03-09 CureVac SE Novel lipid nanoparticles for delivery of nucleic acids
CA3231700A1 (en) 2021-09-10 2023-03-16 Guardian Therapeutics, Llc Fatty acid conjugates of nucleic acids
CA3233512A1 (en) 2021-10-06 2023-04-13 Alexander Muik Multispecific binding agents against pd-l1 and cd137 in combination with anti pd-1 antibodies for treating cancers
CA3234647A1 (en) 2021-10-06 2023-04-13 Genmab A/S Multispecific binding agents against pd-l1 and cd137 in combination therapy
WO2023059854A1 (en) 2021-10-07 2023-04-13 Somalogic Operating Co., Inc. Lung cancer prediction and uses thereof
TW202333802A (zh) 2021-10-11 2023-09-01 德商拜恩迪克公司 用於肺癌之治療性rna(二)
WO2023066881A1 (en) 2021-10-18 2023-04-27 Astrazeneca Ab Inhibition of map3k15 for treating and preventing diabetes
WO2023083439A1 (en) 2021-11-09 2023-05-19 BioNTech SE Tlr7 agonist and combinations for cancer treatment
US20230287434A1 (en) 2021-12-14 2023-09-14 The Procter & Gamble Company Aptamers for personal health care applications
WO2023111196A1 (en) 2021-12-16 2023-06-22 Singapore Health Services Pte. Ltd. Treatment and prevention of glomerular disease
WO2023141248A1 (en) 2022-01-21 2023-07-27 Somalogic Operating Co., Inc. Methods for sample quality assessment
WO2023154452A1 (en) 2022-02-11 2023-08-17 Waypoint Bio, Inc. Cellular staining probes for analyte detection
WO2023183873A1 (en) 2022-03-24 2023-09-28 Mensura Health Inc. Aptamers and uses thereof
WO2023211773A1 (en) 2022-04-24 2023-11-02 Somalogic Operating Co., Inc. Methods for sample quality assessment
WO2023211771A1 (en) 2022-04-24 2023-11-02 Somalogic Operating Co., Inc. Methods for sample quality assessment
WO2023211770A1 (en) 2022-04-24 2023-11-02 Somalogic Operating Co., Inc. Methods for sample quality assessment
WO2023211769A1 (en) 2022-04-24 2023-11-02 Somalogic Operating Co., Inc. Methods for sample quality assessment
WO2023235858A1 (en) 2022-06-03 2023-12-07 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Engineered cell-penetrating antiviral compound
WO2024008755A1 (en) 2022-07-04 2024-01-11 Vib Vzw Blood-cerebrospinal fluid barrier crossing antibodies
WO2024015485A1 (en) 2022-07-14 2024-01-18 Somalogic Operating Co., Inc. Methods of assessing dementia risk
WO2024015486A1 (en) 2022-07-14 2024-01-18 Somalogic Operating Co., Inc. Methods for sample quality assessment
WO2024026474A1 (en) 2022-07-29 2024-02-01 Regeneron Pharmaceuticals, Inc. Compositions and methods for transferrin receptor (tfr)-mediated delivery to the brain and muscle
WO2024030432A1 (en) 2022-08-01 2024-02-08 Gensaic, Inc. Therapeutic phage-derived particles
GB202212077D0 (en) 2022-08-18 2022-10-05 Tribune Therapeutics Ab Agents that inhibit ccn ligand-induced signalling for treating disease
WO2024064322A2 (en) 2022-09-23 2024-03-28 Somalogic Operating Co., Inc. Methods of assessing tobacco use status
WO2024077118A2 (en) 2022-10-06 2024-04-11 Bicara Therapeutics Inc. Multispecific proteins and related methods

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3016575A1 (de) * 1980-04-30 1981-11-05 Merck Patent Gmbh, 6100 Darmstadt Verfahren zur immunologischen bestimmung von enzymen, mittel zur durchfuehrung des verfahrens und seine verwandung
US4683195A (en) * 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
DE3546807C2 (de) * 1985-03-30 1991-03-28 Marc Genf/Geneve Ch Ballivet
US4942122A (en) * 1987-02-24 1990-07-17 Research Education Institute, Inc. Aids prognosis test detecting the presence of antibodies inhibiting HIV reverse transcriptase
US4935363A (en) * 1987-03-30 1990-06-19 Board Of Regents, The University Of Texas System Sterol regulatory elements
WO1989006694A1 (en) * 1988-01-15 1989-07-27 Trustees Of The University Of Pennsylvania Process for selection of proteinaceous substances which mimic growth-inducing molecules
US5043272A (en) * 1989-04-27 1991-08-27 Life Technologies, Incorporated Amplification of nucleic acid sequences using oligonucleotides of random sequence as primers
US5070010A (en) * 1989-10-30 1991-12-03 Hoffman-La Roche Inc. Method for determining anti-viral transactivating activity
HUT62658A (en) * 1990-03-21 1993-05-28 Isis Pharmaceuticals Inc Reagent and process for modifying expression of gene by imitating rna
US5654151A (en) * 1990-06-11 1997-08-05 Nexstar Pharmaceuticals, Inc. High affinity HIV Nucleocapsid nucleic acid ligands
US5763173A (en) * 1990-06-11 1998-06-09 Nexstar Pharmaceuticals, Inc. Nucleic acid ligand inhibitors to DNA polymerases
US5635615A (en) * 1990-06-11 1997-06-03 Nexstar Pharmaceuticals, Inc. High affinity HIV nucleocapsid nucleic acid ligands
US5459015A (en) * 1990-06-11 1995-10-17 Nexstar Pharmaceuticals, Inc. High-affinity RNA ligands of basic fibroblast growth factor
US5705337A (en) * 1990-06-11 1998-01-06 Nexstar Pharmaceuticals, Inc. Systematic evolution of ligands by exponential enrichment: chemi-SELEX
US5270163A (en) * 1990-06-11 1993-12-14 University Research Corporation Methods for identifying nucleic acid ligands
JPH06503715A (ja) * 1990-09-21 1994-04-28 フレッド ハッチンソン キャンサー リサーチ センター タンパク質配列特異的オリゴヌクレオチド配列
AU1435492A (en) * 1991-02-21 1992-09-15 Gilead Sciences, Inc. Aptamer specific for biomolecules and method of making
US5840867A (en) * 1991-02-21 1998-11-24 Gilead Sciences, Inc. Aptamer analogs specific for biomolecules
AU1456092A (en) * 1991-02-21 1992-09-15 Gilead Sciences, Inc. Aptamers specific for thrombin and methods of use
US6013443A (en) * 1995-05-03 2000-01-11 Nexstar Pharmaceuticals, Inc. Systematic evolution of ligands by exponential enrichment: tissue SELEX
DK0833944T3 (da) * 1995-06-07 2009-05-11 Gilead Sciences Inc Nucleinsyreligander som binder til og inhiberer DNA-polymeraser
US5861246A (en) * 1996-01-24 1999-01-19 Yale University Multiple selection process for binding sites of DNA-binding proteins
US5859227A (en) * 1996-07-31 1999-01-12 Bearsden Bio, Inc. RNA sequences which interact with RNA-binding proteins

Also Published As

Publication number Publication date
EP0786469B1 (de) 2006-03-01
US20030198989A1 (en) 2003-10-23
WO1991019813A1 (en) 1991-12-26
IL98456A (en) 1997-03-18
EP0533838A4 (en) 1993-05-26
US6110900A (en) 2000-08-29
IE980162A1 (en) 2000-02-23
US6933116B2 (en) 2005-08-23
JP2007195560A (ja) 2007-08-09
RU2198931C2 (ru) 2003-02-20
EP0533838A1 (de) 1993-03-31
IL112141A (en) 1998-04-05
GR3025594T3 (en) 1998-03-31
US20030157487A1 (en) 2003-08-21
EP1493825A3 (de) 2005-02-09
ES2259800T3 (es) 2006-10-16
IE911979A1 (en) 1991-12-18
EP0786469A3 (de) 1997-08-06
JPH08252100A (ja) 1996-10-01
ES2110444T3 (es) 1998-02-16
DE69128350D1 (de) 1998-01-15
EP1493825A2 (de) 2005-01-05
DE69128350T2 (de) 1998-03-26
KR970002255B1 (ko) 1997-02-26
EP0533838B1 (de) 1997-12-03
DE69133513T2 (de) 2006-09-21
CA2084987A1 (en) 1991-12-12
JP2763958B2 (ja) 1998-06-11
US5843653A (en) 1998-12-01
JP2007195559A (ja) 2007-08-09
ATE160821T1 (de) 1997-12-15
JPH05507413A (ja) 1993-10-28
US5475096A (en) 1995-12-12
EP0786469A2 (de) 1997-07-30
US6331398B1 (en) 2001-12-18
EP1695978A1 (de) 2006-08-30
AU663053B2 (en) 1995-09-28
DK0533838T3 (da) 1998-02-23
AU8206191A (en) 1992-01-07
NZ238492A (en) 1993-07-27
IL98456A0 (en) 1992-07-15
ATE318832T1 (de) 2006-03-15
US5670637A (en) 1997-09-23
JP4276272B2 (ja) 2009-06-10
DK0786469T3 (da) 2006-07-10
CA2084987C (en) 2007-02-13
US5696249A (en) 1997-12-09

Similar Documents

Publication Publication Date Title
DE69133513D1 (de) Verfahren zur Vervendung von Nukleinsäureliganden
RU92016539A (ru) Способ идентификации лигандов, способ получения антитела, способ отбора нуклеиновой кислоты, способ получения смеси нуклеиновых кислот, смесь нуклеиновых кислот, антитело
ATE274520T1 (de) Systematische evoultion von liganden durch exponentielle anreicherung: gewebe-selex
DE3670284D1 (de) Verfahren zur karbonylierung von ethylenisch ungesaettigten verbindungen.
DE3860768D1 (de) Verfahren zur herstellung von hochduktilem tantal-halbzeug.
DE68913251T2 (de) Verfahren zur Verringerung der Heterogenität von monoklonalen Antikörpern.
DE3873094D1 (de) Verfahren zur aufbereitung von gas.
DE69435048D1 (de) Systematische evolution von liganden durch exponentielle anreicherung: fotoselektion von nukleinsäureliganden
DE3862647D1 (de) Verfahren zur durchmischung von schuettguetern.
DE3865000D1 (de) Verfahren zur produktion von alkylaminen.
DE3878766T2 (de) Verfahren zur stabilisierung von isothiazolinonen.
DE3484405D1 (de) Verfahren zur epoxidierung von olefinisch ungesaettigten verbindungen.
DE69105811T2 (de) Verfahren zur Extraktion von bestimmten Nukleinsäurefragmenten.
DE3874510T2 (de) Verfahren zur stabilisierung von hydroisomeraten.
DE3874667D1 (de) Verfahren zur reinigung von methacrylsaeure.
DE3672242D1 (de) Verfahren zur dimerisierung von ethylenisch ungesaettigten verbindungen.
DE3871001D1 (de) Verfahren zur reinigung von phenol.
DE3863549D1 (de) Verfahren zur beseitigung von abfaellen durch verbrennen mit sauerstoff.
DE3865439D1 (de) Verfahren zur gewinnung von alkansulfonamiden.
DE69014482T2 (de) Verfahren zur Gewinnung von Salpetersäure.
DE69015056T2 (de) Trennung von Antikörpern gegen Metallchelate.
DE3775849D1 (de) Verfahren zur produktion von eisen-ii-sulfid.
DE3879351T2 (de) Verfahren zur herstellung von bis(4-amino-phenyl)hexafluoropropan.
DE3882674D1 (de) Verfahren zur bindung von biologischen reagenzien an poroese traeger.
ATE31486T1 (de) Verfahren zur mehrstufigen mischkondensation von daempfen.

Legal Events

Date Code Title Description
8364 No opposition during term of opposition